-- dump date   	20140619_105449
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
349521000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
349521000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
349521000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521000004	Walker A motif; other site
349521000005	ATP binding site [chemical binding]; other site
349521000006	Walker B motif; other site
349521000007	arginine finger; other site
349521000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
349521000009	DnaA box-binding interface [nucleotide binding]; other site
349521000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
349521000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
349521000012	putative DNA binding surface [nucleotide binding]; other site
349521000013	dimer interface [polypeptide binding]; other site
349521000014	beta-clamp/clamp loader binding surface; other site
349521000015	beta-clamp/translesion DNA polymerase binding surface; other site
349521000016	ABC1 family; Region: ABC1; cl17513
349521000017	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
349521000018	MarC family integral membrane protein; Region: MarC; cl00919
349521000019	recombination protein F; Reviewed; Region: recF; PRK00064
349521000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521000021	Walker A/P-loop; other site
349521000022	ATP binding site [chemical binding]; other site
349521000023	Q-loop/lid; other site
349521000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521000025	ABC transporter signature motif; other site
349521000026	Walker B; other site
349521000027	D-loop; other site
349521000028	H-loop/switch region; other site
349521000029	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
349521000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521000031	Mg2+ binding site [ion binding]; other site
349521000032	G-X-G motif; other site
349521000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
349521000034	anchoring element; other site
349521000035	dimer interface [polypeptide binding]; other site
349521000036	ATP binding site [chemical binding]; other site
349521000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
349521000038	active site
349521000039	putative metal-binding site [ion binding]; other site
349521000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
349521000041	AAA domain; Region: AAA_17; pfam13207
349521000042	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
349521000043	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521000044	Walker A/P-loop; other site
349521000045	ATP binding site [chemical binding]; other site
349521000046	Q-loop/lid; other site
349521000047	ABC transporter signature motif; other site
349521000048	Walker B; other site
349521000049	D-loop; other site
349521000050	H-loop/switch region; other site
349521000051	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349521000052	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
349521000053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521000054	dimer interface [polypeptide binding]; other site
349521000055	conserved gate region; other site
349521000056	putative PBP binding loops; other site
349521000057	ABC-ATPase subunit interface; other site
349521000058	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
349521000059	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521000060	Walker A/P-loop; other site
349521000061	ATP binding site [chemical binding]; other site
349521000062	Q-loop/lid; other site
349521000063	ABC transporter signature motif; other site
349521000064	Walker B; other site
349521000065	D-loop; other site
349521000066	H-loop/switch region; other site
349521000067	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349521000068	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
349521000069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521000070	dimer interface [polypeptide binding]; other site
349521000071	conserved gate region; other site
349521000072	putative PBP binding loops; other site
349521000073	ABC-ATPase subunit interface; other site
349521000074	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
349521000075	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
349521000076	peptide binding site [polypeptide binding]; other site
349521000077	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521000078	dimerization interface [polypeptide binding]; other site
349521000079	putative DNA binding site [nucleotide binding]; other site
349521000080	putative Zn2+ binding site [ion binding]; other site
349521000081	fumarate hydratase; Reviewed; Region: fumC; PRK00485
349521000082	Class II fumarases; Region: Fumarase_classII; cd01362
349521000083	active site
349521000084	tetramer interface [polypeptide binding]; other site
349521000085	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
349521000086	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
349521000087	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
349521000088	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
349521000089	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
349521000090	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521000091	active site
349521000092	motif I; other site
349521000093	motif II; other site
349521000094	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
349521000095	tRNA binding surface [nucleotide binding]; other site
349521000096	anticodon binding site; other site
349521000097	DALR anticodon binding domain; Region: DALR_1; pfam05746
349521000098	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
349521000099	dimer interface [polypeptide binding]; other site
349521000100	motif 1; other site
349521000101	active site
349521000102	motif 2; other site
349521000103	motif 3; other site
349521000104	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
349521000105	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
349521000106	putative acyl-acceptor binding pocket; other site
349521000107	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521000108	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
349521000109	Cation transport protein; Region: TrkH; cl17365
349521000110	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
349521000111	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
349521000112	TrkA-N domain; Region: TrkA_N; pfam02254
349521000113	TrkA-C domain; Region: TrkA_C; pfam02080
349521000114	TrkA-N domain; Region: TrkA_N; pfam02254
349521000115	TrkA-C domain; Region: TrkA_C; pfam02080
349521000116	16S rRNA methyltransferase B; Provisional; Region: PRK10901
349521000117	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
349521000118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521000119	S-adenosylmethionine binding site [chemical binding]; other site
349521000120	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
349521000121	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
349521000122	putative active site [active]
349521000123	substrate binding site [chemical binding]; other site
349521000124	putative cosubstrate binding site; other site
349521000125	catalytic site [active]
349521000126	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
349521000127	substrate binding site [chemical binding]; other site
349521000128	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
349521000129	active site
349521000130	catalytic residues [active]
349521000131	metal binding site [ion binding]; metal-binding site
349521000132	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
349521000133	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349521000134	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
349521000135	DNA protecting protein DprA; Region: dprA; TIGR00732
349521000136	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
349521000137	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
349521000138	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
349521000139	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
349521000140	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
349521000141	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
349521000142	shikimate binding site; other site
349521000143	NAD(P) binding site [chemical binding]; other site
349521000144	flagellar motor protein MotP; Reviewed; Region: PRK06926
349521000145	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
349521000146	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
349521000147	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
349521000148	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521000149	ligand binding site [chemical binding]; other site
349521000150	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
349521000151	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
349521000152	putative dimer interface [polypeptide binding]; other site
349521000153	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
349521000154	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
349521000155	trimer interface [polypeptide binding]; other site
349521000156	putative metal binding site [ion binding]; other site
349521000157	oligopeptidase A; Provisional; Region: PRK10911
349521000158	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
349521000159	active site
349521000160	Zn binding site [ion binding]; other site
349521000161	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
349521000162	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
349521000163	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
349521000164	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
349521000165	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
349521000166	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
349521000167	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
349521000168	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349521000169	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
349521000170	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
349521000171	Subunit I/III interface [polypeptide binding]; other site
349521000172	D-pathway; other site
349521000173	Subunit I/VIIc interface [polypeptide binding]; other site
349521000174	Subunit I/IV interface [polypeptide binding]; other site
349521000175	Subunit I/II interface [polypeptide binding]; other site
349521000176	Low-spin heme (heme a) binding site [chemical binding]; other site
349521000177	Subunit I/VIIa interface [polypeptide binding]; other site
349521000178	Subunit I/VIa interface [polypeptide binding]; other site
349521000179	Dimer interface; other site
349521000180	Putative water exit pathway; other site
349521000181	Binuclear center (heme a3/CuB) [ion binding]; other site
349521000182	K-pathway; other site
349521000183	Subunit I/Vb interface [polypeptide binding]; other site
349521000184	Putative proton exit pathway; other site
349521000185	Subunit I/VIb interface; other site
349521000186	Subunit I/VIc interface [polypeptide binding]; other site
349521000187	Electron transfer pathway; other site
349521000188	Subunit I/VIIIb interface [polypeptide binding]; other site
349521000189	Subunit I/VIIb interface [polypeptide binding]; other site
349521000190	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
349521000191	Subunit III/VIIa interface [polypeptide binding]; other site
349521000192	Phospholipid binding site [chemical binding]; other site
349521000193	Subunit I/III interface [polypeptide binding]; other site
349521000194	Subunit III/VIb interface [polypeptide binding]; other site
349521000195	Subunit III/VIa interface; other site
349521000196	Subunit III/Vb interface [polypeptide binding]; other site
349521000197	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
349521000198	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
349521000199	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
349521000200	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
349521000201	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
349521000202	UbiA prenyltransferase family; Region: UbiA; pfam01040
349521000203	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
349521000204	Beta-lactamase; Region: Beta-lactamase; pfam00144
349521000205	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
349521000206	Strictosidine synthase; Region: Str_synth; pfam03088
349521000207	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
349521000208	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
349521000209	active site
349521000210	Zn binding site [ion binding]; other site
349521000211	DNA photolyase; Region: DNA_photolyase; pfam00875
349521000212	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
349521000213	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
349521000214	dimer interface [polypeptide binding]; other site
349521000215	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
349521000216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521000217	active site
349521000218	phosphorylation site [posttranslational modification]
349521000219	intermolecular recognition site; other site
349521000220	dimerization interface [polypeptide binding]; other site
349521000221	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521000222	DNA binding site [nucleotide binding]
349521000223	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
349521000224	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521000225	dimerization interface [polypeptide binding]; other site
349521000226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521000227	dimer interface [polypeptide binding]; other site
349521000228	phosphorylation site [posttranslational modification]
349521000229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521000230	ATP binding site [chemical binding]; other site
349521000231	Mg2+ binding site [ion binding]; other site
349521000232	G-X-G motif; other site
349521000233	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
349521000234	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349521000235	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349521000236	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
349521000237	conserved cys residue [active]
349521000238	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
349521000239	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
349521000240	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
349521000241	putative dimer interface [polypeptide binding]; other site
349521000242	N-terminal domain interface [polypeptide binding]; other site
349521000243	putative substrate binding pocket (H-site) [chemical binding]; other site
349521000244	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521000245	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
349521000246	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
349521000247	dimerization interface [polypeptide binding]; other site
349521000248	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
349521000249	ATP binding site [chemical binding]; other site
349521000250	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
349521000251	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
349521000252	HupF/HypC family; Region: HupF_HypC; pfam01455
349521000253	Acylphosphatase; Region: Acylphosphatase; pfam00708
349521000254	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
349521000255	HypF finger; Region: zf-HYPF; pfam07503
349521000256	HypF finger; Region: zf-HYPF; pfam07503
349521000257	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
349521000258	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349521000259	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521000260	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521000261	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521000262	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521000263	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521000264	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
349521000265	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521000266	dimerization interface [polypeptide binding]; other site
349521000267	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521000268	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521000269	dimer interface [polypeptide binding]; other site
349521000270	putative CheW interface [polypeptide binding]; other site
349521000271	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
349521000272	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
349521000273	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
349521000274	Cellulose binding domain; Region: CBM_2; pfam00553
349521000275	Cellulose binding domain; Region: CBM_2; pfam00553
349521000276	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
349521000277	FOG: PKD repeat [General function prediction only]; Region: COG3291
349521000278	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
349521000279	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
349521000280	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
349521000281	Cellulose binding domain; Region: CBM_2; pfam00553
349521000282	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
349521000283	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
349521000284	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
349521000285	metal ion-dependent adhesion site (MIDAS); other site
349521000286	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
349521000287	active site
349521000288	catalytic site [active]
349521000289	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
349521000290	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349521000291	putative active site [active]
349521000292	putative NTP binding site [chemical binding]; other site
349521000293	putative nucleic acid binding site [nucleotide binding]; other site
349521000294	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
349521000295	Autotransporter beta-domain; Region: Autotransporter; smart00869
349521000296	Calx-beta domain; Region: Calx-beta; cl02522
349521000297	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
349521000298	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
349521000299	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
349521000300	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
349521000301	hypothetical protein; Provisional; Region: PRK05409
349521000302	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
349521000303	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
349521000304	ATP-binding site [chemical binding]; other site
349521000305	Sugar specificity; other site
349521000306	Pyrimidine base specificity; other site
349521000307	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349521000308	active site residue [active]
349521000309	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
349521000310	active site residue [active]
349521000311	sulfite oxidase; Provisional; Region: PLN00177
349521000312	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
349521000313	Moco binding site; other site
349521000314	metal coordination site [ion binding]; other site
349521000315	dimerization interface [polypeptide binding]; other site
349521000316	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
349521000317	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
349521000318	Protein of unknown function (DUF2396); Region: DUF2396; cl09868
349521000319	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
349521000320	nickel binding site [ion binding]; other site
349521000321	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
349521000322	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
349521000323	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
349521000324	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349521000325	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
349521000326	catalytic loop [active]
349521000327	iron binding site [ion binding]; other site
349521000328	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
349521000329	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
349521000330	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
349521000331	putative dimer interface [polypeptide binding]; other site
349521000332	[2Fe-2S] cluster binding site [ion binding]; other site
349521000333	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
349521000334	SLBB domain; Region: SLBB; pfam10531
349521000335	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
349521000336	NAD-dependent deacetylase; Provisional; Region: PRK00481
349521000337	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
349521000338	NAD+ binding site [chemical binding]; other site
349521000339	substrate binding site [chemical binding]; other site
349521000340	Zn binding site [ion binding]; other site
349521000341	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
349521000342	catalytic residues [active]
349521000343	dimer interface [polypeptide binding]; other site
349521000344	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521000345	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521000346	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521000347	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
349521000348	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521000349	dimerization interface [polypeptide binding]; other site
349521000350	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521000351	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521000352	active site
349521000353	ATP binding site [chemical binding]; other site
349521000354	substrate binding site [chemical binding]; other site
349521000355	activation loop (A-loop); other site
349521000356	PBP superfamily domain; Region: PBP_like_2; cl17296
349521000357	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
349521000358	ligand binding site [chemical binding]; other site
349521000359	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
349521000360	serine/threonine protein kinase; Provisional; Region: PRK11768
349521000361	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
349521000362	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
349521000363	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
349521000364	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
349521000365	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
349521000366	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
349521000367	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
349521000368	Fatty acid desaturase; Region: FA_desaturase; pfam00487
349521000369	putative di-iron ligands [ion binding]; other site
349521000370	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
349521000371	Lamin Tail Domain; Region: LTD; pfam00932
349521000372	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521000373	Endonuclease I; Region: Endonuclease_1; pfam04231
349521000374	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
349521000375	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
349521000376	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
349521000377	putative NAD(P) binding site [chemical binding]; other site
349521000378	putative active site [active]
349521000379	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349521000380	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
349521000381	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
349521000382	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
349521000383	active site
349521000384	hydrophilic channel; other site
349521000385	dimerization interface [polypeptide binding]; other site
349521000386	catalytic residues [active]
349521000387	active site lid [active]
349521000388	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
349521000389	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
349521000390	ThiC-associated domain; Region: ThiC-associated; pfam13667
349521000391	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
349521000392	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
349521000393	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
349521000394	thiS-thiF/thiG interaction site; other site
349521000395	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
349521000396	ThiS interaction site; other site
349521000397	putative active site [active]
349521000398	tetramer interface [polypeptide binding]; other site
349521000399	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
349521000400	dimer interface [polypeptide binding]; other site
349521000401	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
349521000402	substrate binding site [chemical binding]; other site
349521000403	ATP binding site [chemical binding]; other site
349521000404	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
349521000405	thiamine phosphate binding site [chemical binding]; other site
349521000406	active site
349521000407	pyrophosphate binding site [ion binding]; other site
349521000408	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521000409	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521000410	substrate binding pocket [chemical binding]; other site
349521000411	membrane-bound complex binding site; other site
349521000412	hinge residues; other site
349521000413	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
349521000414	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521000415	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521000416	Walker A/P-loop; other site
349521000417	ATP binding site [chemical binding]; other site
349521000418	Q-loop/lid; other site
349521000419	ABC transporter signature motif; other site
349521000420	Walker B; other site
349521000421	D-loop; other site
349521000422	H-loop/switch region; other site
349521000423	Alpha trans-inducing protein (Alpha-TIF); Region: Alpha_TIF; cl03493
349521000424	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
349521000425	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
349521000426	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
349521000427	active site
349521000428	FOG: CBS domain [General function prediction only]; Region: COG0517
349521000429	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
349521000430	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
349521000431	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349521000432	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521000433	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349521000434	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
349521000435	catalytic triad [active]
349521000436	dimer interface [polypeptide binding]; other site
349521000437	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521000438	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
349521000439	Ricin-type beta-trefoil; Region: RICIN; smart00458
349521000440	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
349521000441	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
349521000442	putative sugar binding sites [chemical binding]; other site
349521000443	Q-X-W motif; other site
349521000444	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
349521000445	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
349521000446	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521000447	ATP binding site [chemical binding]; other site
349521000448	putative Mg++ binding site [ion binding]; other site
349521000449	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521000450	nucleotide binding region [chemical binding]; other site
349521000451	ATP-binding site [chemical binding]; other site
349521000452	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
349521000453	HRDC domain; Region: HRDC; pfam00570
349521000454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521000455	dimer interface [polypeptide binding]; other site
349521000456	conserved gate region; other site
349521000457	ABC-ATPase subunit interface; other site
349521000458	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
349521000459	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
349521000460	Walker A/P-loop; other site
349521000461	ATP binding site [chemical binding]; other site
349521000462	Q-loop/lid; other site
349521000463	ABC transporter signature motif; other site
349521000464	Walker B; other site
349521000465	D-loop; other site
349521000466	H-loop/switch region; other site
349521000467	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521000468	dimer interface [polypeptide binding]; other site
349521000469	conserved gate region; other site
349521000470	putative PBP binding loops; other site
349521000471	ABC-ATPase subunit interface; other site
349521000472	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
349521000473	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
349521000474	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
349521000475	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
349521000476	RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204
349521000477	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
349521000478	putative active site [active]
349521000479	adenylation catalytic residue [active]
349521000480	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
349521000481	hypothetical protein; Reviewed; Region: PRK09588
349521000482	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
349521000483	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
349521000484	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521000485	Walker A motif; other site
349521000486	ATP binding site [chemical binding]; other site
349521000487	Walker B motif; other site
349521000488	arginine finger; other site
349521000489	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
349521000490	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
349521000491	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
349521000492	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521000493	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349521000494	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
349521000495	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521000496	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521000497	metal binding site [ion binding]; metal-binding site
349521000498	active site
349521000499	I-site; other site
349521000500	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
349521000501	active site
349521000502	Predicted amidohydrolase [General function prediction only]; Region: COG0388
349521000503	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
349521000504	active site
349521000505	catalytic triad [active]
349521000506	dimer interface [polypeptide binding]; other site
349521000507	Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590
349521000508	putative active site [active]
349521000509	catalytic site [active]
349521000510	putative metal binding site [ion binding]; other site
349521000511	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
349521000512	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
349521000513	putative sugar binding sites [chemical binding]; other site
349521000514	Q-X-W motif; other site
349521000515	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521000516	non-specific DNA binding site [nucleotide binding]; other site
349521000517	salt bridge; other site
349521000518	sequence-specific DNA binding site [nucleotide binding]; other site
349521000519	Protein of unknown function (DUF1513); Region: DUF1513; pfam07433
349521000520	Imelysin; Region: Peptidase_M75; pfam09375
349521000521	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
349521000522	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
349521000523	Imelysin; Region: Peptidase_M75; cl09159
349521000524	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
349521000525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
349521000526	AAA domain; Region: AAA_33; pfam13671
349521000527	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
349521000528	translation initiation factor Sui1; Validated; Region: PRK06824
349521000529	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
349521000530	putative rRNA binding site [nucleotide binding]; other site
349521000531	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
349521000532	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
349521000533	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521000534	DNA-binding site [nucleotide binding]; DNA binding site
349521000535	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521000536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521000537	homodimer interface [polypeptide binding]; other site
349521000538	catalytic residue [active]
349521000539	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
349521000540	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349521000541	Predicted transcriptional regulator [Transcription]; Region: COG2378
349521000542	HTH domain; Region: HTH_11; pfam08279
349521000543	WYL domain; Region: WYL; pfam13280
349521000544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521000545	S-adenosylmethionine binding site [chemical binding]; other site
349521000546	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
349521000547	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
349521000548	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
349521000549	active site
349521000550	catalytic site [active]
349521000551	replicative DNA helicase; Provisional; Region: PRK05973
349521000552	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521000553	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521000554	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
349521000555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521000556	dimer interface [polypeptide binding]; other site
349521000557	conserved gate region; other site
349521000558	putative PBP binding loops; other site
349521000559	ABC-ATPase subunit interface; other site
349521000560	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349521000561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521000562	dimer interface [polypeptide binding]; other site
349521000563	conserved gate region; other site
349521000564	putative PBP binding loops; other site
349521000565	ABC-ATPase subunit interface; other site
349521000566	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
349521000567	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
349521000568	active site
349521000569	catalytic site [active]
349521000570	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
349521000571	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349521000572	Walker A/P-loop; other site
349521000573	ATP binding site [chemical binding]; other site
349521000574	Q-loop/lid; other site
349521000575	ABC transporter signature motif; other site
349521000576	Walker B; other site
349521000577	D-loop; other site
349521000578	H-loop/switch region; other site
349521000579	TOBE domain; Region: TOBE_2; pfam08402
349521000580	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521000581	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521000582	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
349521000583	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521000584	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521000585	dimerization interface [polypeptide binding]; other site
349521000586	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521000587	dimer interface [polypeptide binding]; other site
349521000588	phosphorylation site [posttranslational modification]
349521000589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521000590	ATP binding site [chemical binding]; other site
349521000591	Mg2+ binding site [ion binding]; other site
349521000592	G-X-G motif; other site
349521000593	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324
349521000594	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349521000595	putative ligand binding site [chemical binding]; other site
349521000596	elongation factor P; Provisional; Region: PRK04542
349521000597	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
349521000598	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
349521000599	RNA binding site [nucleotide binding]; other site
349521000600	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
349521000601	RNA binding site [nucleotide binding]; other site
349521000602	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
349521000603	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
349521000604	Pirin-related protein [General function prediction only]; Region: COG1741
349521000605	Pirin; Region: Pirin; pfam02678
349521000606	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
349521000607	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521000608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521000609	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521000610	dimerization interface [polypeptide binding]; other site
349521000611	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
349521000612	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
349521000613	metal binding site [ion binding]; metal-binding site
349521000614	dimer interface [polypeptide binding]; other site
349521000615	FOG: CBS domain [General function prediction only]; Region: COG0517
349521000616	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803
349521000617	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
349521000618	AAA domain; Region: AAA_30; pfam13604
349521000619	Family description; Region: UvrD_C_2; pfam13538
349521000620	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
349521000621	Family description; Region: UvrD_C_2; pfam13538
349521000622	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
349521000623	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
349521000624	Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859
349521000625	putative active site [active]
349521000626	Zn binding site [ion binding]; other site
349521000627	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
349521000628	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
349521000629	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349521000630	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521000631	Coenzyme A binding pocket [chemical binding]; other site
349521000632	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
349521000633	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
349521000634	G1 box; other site
349521000635	GTP/Mg2+ binding site [chemical binding]; other site
349521000636	G2 box; other site
349521000637	Switch I region; other site
349521000638	G3 box; other site
349521000639	Switch II region; other site
349521000640	G4 box; other site
349521000641	G5 box; other site
349521000642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
349521000643	dimer interface [polypeptide binding]; other site
349521000644	phosphorylation site [posttranslational modification]
349521000645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521000646	ATP binding site [chemical binding]; other site
349521000647	Mg2+ binding site [ion binding]; other site
349521000648	G-X-G motif; other site
349521000649	Response regulator receiver domain; Region: Response_reg; pfam00072
349521000650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521000651	active site
349521000652	phosphorylation site [posttranslational modification]
349521000653	intermolecular recognition site; other site
349521000654	dimerization interface [polypeptide binding]; other site
349521000655	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
349521000656	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
349521000657	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
349521000658	Walker A motif; other site
349521000659	ATP binding site [chemical binding]; other site
349521000660	Walker B motif; other site
349521000661	AAA domain; Region: AAA_21; pfam13304
349521000662	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
349521000663	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
349521000664	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
349521000665	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
349521000666	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
349521000667	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349521000668	Walker A/P-loop; other site
349521000669	ATP binding site [chemical binding]; other site
349521000670	Q-loop/lid; other site
349521000671	ABC transporter signature motif; other site
349521000672	Walker B; other site
349521000673	D-loop; other site
349521000674	H-loop/switch region; other site
349521000675	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521000676	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
349521000677	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521000678	selenophosphate synthetase; Provisional; Region: PRK00943
349521000679	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
349521000680	dimerization interface [polypeptide binding]; other site
349521000681	putative ATP binding site [chemical binding]; other site
349521000682	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
349521000683	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
349521000684	active site residue [active]
349521000685	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145
349521000686	SEC-C motif; Region: SEC-C; pfam02810
349521000687	YceI-like domain; Region: YceI; pfam04264
349521000688	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
349521000689	carbohydrate binding site [chemical binding]; other site
349521000690	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
349521000691	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
349521000692	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
349521000693	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
349521000694	active site
349521000695	catalytic site [active]
349521000696	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
349521000697	Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861
349521000698	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
349521000699	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521000700	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521000701	Isochorismatase family; Region: Isochorismatase; pfam00857
349521000702	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
349521000703	catalytic triad [active]
349521000704	conserved cis-peptide bond; other site
349521000705	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349521000706	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
349521000707	conserved cys residue [active]
349521000708	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521000709	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521000710	HDOD domain; Region: HDOD; pfam08668
349521000711	GAF domain; Region: GAF; pfam01590
349521000712	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
349521000713	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
349521000714	NADP binding site [chemical binding]; other site
349521000715	active site
349521000716	putative substrate binding site [chemical binding]; other site
349521000717	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521000718	EamA-like transporter family; Region: EamA; pfam00892
349521000719	EamA-like transporter family; Region: EamA; pfam00892
349521000720	RDD family; Region: RDD; pfam06271
349521000721	Integral membrane protein DUF95; Region: DUF95; pfam01944
349521000722	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
349521000723	MoxR-like ATPases [General function prediction only]; Region: COG0714
349521000724	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521000725	Walker A motif; other site
349521000726	ATP binding site [chemical binding]; other site
349521000727	Walker B motif; other site
349521000728	arginine finger; other site
349521000729	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
349521000730	Protein of unknown function DUF58; Region: DUF58; pfam01882
349521000731	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
349521000732	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
349521000733	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
349521000734	active site
349521000735	homodimer interface [polypeptide binding]; other site
349521000736	catalytic site [active]
349521000737	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
349521000738	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
349521000739	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521000740	active site
349521000741	motif I; other site
349521000742	motif II; other site
349521000743	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521000744	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
349521000745	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
349521000746	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521000747	Zn2+ binding site [ion binding]; other site
349521000748	Mg2+ binding site [ion binding]; other site
349521000749	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521000750	metal binding site [ion binding]; metal-binding site
349521000751	active site
349521000752	I-site; other site
349521000753	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521000754	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
349521000755	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
349521000756	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
349521000757	NHL repeat; Region: NHL; pfam01436
349521000758	NHL repeat; Region: NHL; pfam01436
349521000759	NHL repeat; Region: NHL; pfam01436
349521000760	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521000761	substrate binding pocket [chemical binding]; other site
349521000762	membrane-bound complex binding site; other site
349521000763	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
349521000764	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
349521000765	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
349521000766	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521000767	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
349521000768	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
349521000769	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521000770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521000771	Walker A/P-loop; other site
349521000772	ATP binding site [chemical binding]; other site
349521000773	Q-loop/lid; other site
349521000774	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521000775	ABC transporter signature motif; other site
349521000776	Walker B; other site
349521000777	D-loop; other site
349521000778	ABC transporter; Region: ABC_tran_2; pfam12848
349521000779	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521000780	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
349521000781	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
349521000782	dimerization interface [polypeptide binding]; other site
349521000783	ligand binding site [chemical binding]; other site
349521000784	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
349521000785	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
349521000786	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
349521000787	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349521000788	catalytic residues [active]
349521000789	transcription termination factor Rho; Provisional; Region: rho; PRK09376
349521000790	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
349521000791	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
349521000792	RNA binding site [nucleotide binding]; other site
349521000793	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
349521000794	multimer interface [polypeptide binding]; other site
349521000795	Walker A motif; other site
349521000796	ATP binding site [chemical binding]; other site
349521000797	Walker B motif; other site
349521000798	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
349521000799	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
349521000800	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349521000801	catalytic loop [active]
349521000802	iron binding site [ion binding]; other site
349521000803	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
349521000804	FAD binding pocket [chemical binding]; other site
349521000805	FAD binding motif [chemical binding]; other site
349521000806	phosphate binding motif [ion binding]; other site
349521000807	beta-alpha-beta structure motif; other site
349521000808	NAD binding pocket [chemical binding]; other site
349521000809	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
349521000810	HemY protein N-terminus; Region: HemY_N; pfam07219
349521000811	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
349521000812	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
349521000813	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
349521000814	active site
349521000815	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
349521000816	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
349521000817	domain interfaces; other site
349521000818	active site
349521000819	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
349521000820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521000821	active site
349521000822	phosphorylation site [posttranslational modification]
349521000823	intermolecular recognition site; other site
349521000824	dimerization interface [polypeptide binding]; other site
349521000825	LytTr DNA-binding domain; Region: LytTR; smart00850
349521000826	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
349521000827	Histidine kinase; Region: His_kinase; pfam06580
349521000828	argininosuccinate lyase; Provisional; Region: PRK00855
349521000829	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
349521000830	active sites [active]
349521000831	tetramer interface [polypeptide binding]; other site
349521000832	adenylate cyclase; Provisional; Region: cyaA; PRK09450
349521000833	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
349521000834	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
349521000835	diaminopimelate decarboxylase; Region: lysA; TIGR01048
349521000836	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
349521000837	active site
349521000838	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349521000839	substrate binding site [chemical binding]; other site
349521000840	catalytic residues [active]
349521000841	dimer interface [polypeptide binding]; other site
349521000842	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
349521000843	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
349521000844	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
349521000845	Protein of unknown function, DUF484; Region: DUF484; cl17449
349521000846	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
349521000847	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349521000848	active site
349521000849	DNA binding site [nucleotide binding]
349521000850	Int/Topo IB signature motif; other site
349521000851	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521000852	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521000853	metal binding site [ion binding]; metal-binding site
349521000854	active site
349521000855	I-site; other site
349521000856	Response regulator receiver domain; Region: Response_reg; pfam00072
349521000857	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521000858	active site
349521000859	phosphorylation site [posttranslational modification]
349521000860	intermolecular recognition site; other site
349521000861	dimerization interface [polypeptide binding]; other site
349521000862	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349521000863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521000864	active site
349521000865	phosphorylation site [posttranslational modification]
349521000866	intermolecular recognition site; other site
349521000867	dimerization interface [polypeptide binding]; other site
349521000868	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521000869	DNA binding residues [nucleotide binding]
349521000870	dimerization interface [polypeptide binding]; other site
349521000871	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521000872	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521000873	dimer interface [polypeptide binding]; other site
349521000874	phosphorylation site [posttranslational modification]
349521000875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521000876	ATP binding site [chemical binding]; other site
349521000877	Mg2+ binding site [ion binding]; other site
349521000878	G-X-G motif; other site
349521000879	Response regulator receiver domain; Region: Response_reg; pfam00072
349521000880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521000881	active site
349521000882	phosphorylation site [posttranslational modification]
349521000883	intermolecular recognition site; other site
349521000884	dimerization interface [polypeptide binding]; other site
349521000885	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
349521000886	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521000887	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521000888	substrate binding pocket [chemical binding]; other site
349521000889	membrane-bound complex binding site; other site
349521000890	hinge residues; other site
349521000891	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521000892	dimer interface [polypeptide binding]; other site
349521000893	phosphorylation site [posttranslational modification]
349521000894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521000895	ATP binding site [chemical binding]; other site
349521000896	Mg2+ binding site [ion binding]; other site
349521000897	G-X-G motif; other site
349521000898	Response regulator receiver domain; Region: Response_reg; pfam00072
349521000899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521000900	active site
349521000901	phosphorylation site [posttranslational modification]
349521000902	intermolecular recognition site; other site
349521000903	dimerization interface [polypeptide binding]; other site
349521000904	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
349521000905	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
349521000906	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
349521000907	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
349521000908	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349521000909	putative catalytic residue [active]
349521000910	Transcriptional regulators [Transcription]; Region: GntR; COG1802
349521000911	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521000912	DNA-binding site [nucleotide binding]; DNA binding site
349521000913	FCD domain; Region: FCD; pfam07729
349521000914	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
349521000915	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
349521000916	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
349521000917	NAD binding site [chemical binding]; other site
349521000918	Phe binding site; other site
349521000919	Fructosamine kinase; Region: Fructosamin_kin; cl17579
349521000920	Phosphotransferase enzyme family; Region: APH; pfam01636
349521000921	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
349521000922	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
349521000923	putative NAD(P) binding site [chemical binding]; other site
349521000924	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349521000925	Protein of unknown function (DUF3359); Region: DUF3359; pfam11839
349521000926	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
349521000927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521000928	dimer interface [polypeptide binding]; other site
349521000929	phosphorylation site [posttranslational modification]
349521000930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521000931	ATP binding site [chemical binding]; other site
349521000932	Mg2+ binding site [ion binding]; other site
349521000933	G-X-G motif; other site
349521000934	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349521000935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521000936	active site
349521000937	phosphorylation site [posttranslational modification]
349521000938	intermolecular recognition site; other site
349521000939	dimerization interface [polypeptide binding]; other site
349521000940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521000941	Walker A motif; other site
349521000942	ATP binding site [chemical binding]; other site
349521000943	Walker B motif; other site
349521000944	arginine finger; other site
349521000945	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521000946	M28 Zn-Peptidases; Region: M28_like_1; cd05640
349521000947	Peptidase family M28; Region: Peptidase_M28; pfam04389
349521000948	metal binding site [ion binding]; metal-binding site
349521000949	Predicted permeases [General function prediction only]; Region: RarD; COG2962
349521000950	EamA-like transporter family; Region: EamA; pfam00892
349521000951	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
349521000952	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
349521000953	active site
349521000954	FMN binding site [chemical binding]; other site
349521000955	substrate binding site [chemical binding]; other site
349521000956	3Fe-4S cluster binding site [ion binding]; other site
349521000957	SnoaL-like domain; Region: SnoaL_2; pfam12680
349521000958	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
349521000959	Fatty acid desaturase; Region: FA_desaturase; pfam00487
349521000960	Di-iron ligands [ion binding]; other site
349521000961	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
349521000962	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349521000963	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
349521000964	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
349521000965	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521000966	S-adenosylmethionine binding site [chemical binding]; other site
349521000967	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
349521000968	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
349521000969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521000970	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
349521000971	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
349521000972	CHASE domain; Region: CHASE; cl01369
349521000973	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521000974	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521000975	metal binding site [ion binding]; metal-binding site
349521000976	active site
349521000977	I-site; other site
349521000978	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521000979	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
349521000980	trimer interface; other site
349521000981	sugar binding site [chemical binding]; other site
349521000982	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
349521000983	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
349521000984	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
349521000985	putative active site [active]
349521000986	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
349521000987	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
349521000988	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
349521000989	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
349521000990	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
349521000991	putative active site [active]
349521000992	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
349521000993	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
349521000994	active site
349521000995	intersubunit interface [polypeptide binding]; other site
349521000996	catalytic residue [active]
349521000997	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256
349521000998	putative active site [active]
349521000999	Zn binding site [ion binding]; other site
349521001000	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
349521001001	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
349521001002	Protein of unknown function, DUF482; Region: DUF482; pfam04339
349521001003	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521001004	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521001005	substrate binding pocket [chemical binding]; other site
349521001006	membrane-bound complex binding site; other site
349521001007	hinge residues; other site
349521001008	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
349521001009	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
349521001010	generic binding surface II; other site
349521001011	generic binding surface I; other site
349521001012	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
349521001013	putative catalytic site [active]
349521001014	putative metal binding site [ion binding]; other site
349521001015	putative phosphate binding site [ion binding]; other site
349521001016	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
349521001017	GIY-YIG motif/motif A; other site
349521001018	putative active site [active]
349521001019	putative metal binding site [ion binding]; other site
349521001020	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
349521001021	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521001022	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
349521001023	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
349521001024	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
349521001025	Ion channel; Region: Ion_trans_2; pfam07885
349521001026	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
349521001027	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
349521001028	active site
349521001029	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
349521001030	PAS fold; Region: PAS; pfam00989
349521001031	PAS domain; Region: PAS; smart00091
349521001032	PAS domain; Region: PAS_9; pfam13426
349521001033	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521001034	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521001035	metal binding site [ion binding]; metal-binding site
349521001036	active site
349521001037	I-site; other site
349521001038	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
349521001039	Baseplate J-like protein; Region: Baseplate_J; cl01294
349521001040	Protein of unknown function (DUF2590); Region: DUF2590; pfam10761
349521001041	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
349521001042	Protein of unknown function (DUF2765); Region: DUF2765; pfam10963
349521001043	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
349521001044	Protein of unknown function (DUF2597); Region: DUF2597; pfam10772
349521001045	Protein of unknown function (DUF2586); Region: DUF2586; pfam10758
349521001046	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
349521001047	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
349521001048	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
349521001049	terminase endonuclease subunit; Provisional; Region: M; PHA02537
349521001050	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
349521001051	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
349521001052	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
349521001053	terminase ATPase subunit; Provisional; Region: P; PHA02535
349521001054	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
349521001055	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
349521001056	Phage-related protein [Function unknown]; Region: COG4695; cl01923
349521001057	Phage portal protein; Region: Phage_portal; pfam04860
349521001058	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
349521001059	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
349521001060	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
349521001061	active site
349521001062	catalytic site [active]
349521001063	substrate binding site [chemical binding]; other site
349521001064	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
349521001065	active site
349521001066	metal binding site [ion binding]; metal-binding site
349521001067	interdomain interaction site; other site
349521001068	integrase; Provisional; Region: int; PHA02601
349521001069	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349521001070	active site
349521001071	DNA binding site [nucleotide binding]
349521001072	Int/Topo IB signature motif; other site
349521001073	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
349521001074	hypothetical protein; Provisional; Region: PRK09256
349521001075	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
349521001076	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
349521001077	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
349521001078	active site
349521001079	metal binding site [ion binding]; metal-binding site
349521001080	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
349521001081	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521001082	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521001083	substrate binding pocket [chemical binding]; other site
349521001084	membrane-bound complex binding site; other site
349521001085	hinge residues; other site
349521001086	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
349521001087	active site
349521001088	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
349521001089	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
349521001090	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
349521001091	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
349521001092	DctM-like transporters; Region: DctM; pfam06808
349521001093	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
349521001094	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
349521001095	Histidine kinase; Region: HisKA_3; pfam07730
349521001096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521001097	ATP binding site [chemical binding]; other site
349521001098	Mg2+ binding site [ion binding]; other site
349521001099	G-X-G motif; other site
349521001100	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349521001101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001102	active site
349521001103	phosphorylation site [posttranslational modification]
349521001104	intermolecular recognition site; other site
349521001105	dimerization interface [polypeptide binding]; other site
349521001106	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521001107	DNA binding residues [nucleotide binding]
349521001108	dimerization interface [polypeptide binding]; other site
349521001109	NlpC/P60 family; Region: NLPC_P60; pfam00877
349521001110	Low molecular weight phosphatase family; Region: LMWPc; cl00105
349521001111	active site
349521001112	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
349521001113	GIY-YIG motif/motif A; other site
349521001114	active site
349521001115	catalytic site [active]
349521001116	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349521001117	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
349521001118	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
349521001119	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
349521001120	MOSC domain; Region: MOSC; pfam03473
349521001121	Uncharacterized conserved protein [Function unknown]; Region: COG4278
349521001122	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
349521001123	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349521001124	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
349521001125	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521001126	motif II; other site
349521001127	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
349521001128	Protein of unknown function DUF72; Region: DUF72; pfam01904
349521001129	pyruvate kinase; Provisional; Region: PRK05826
349521001130	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
349521001131	domain interfaces; other site
349521001132	active site
349521001133	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
349521001134	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
349521001135	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
349521001136	phosphogluconate dehydratase; Validated; Region: PRK09054
349521001137	6-phosphogluconate dehydratase; Region: edd; TIGR01196
349521001138	glucokinase; Provisional; Region: glk; PRK00292
349521001139	glucokinase, proteobacterial type; Region: glk; TIGR00749
349521001140	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349521001141	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349521001142	active site
349521001143	catalytic tetrad [active]
349521001144	lipoprotein; Provisional; Region: PRK10759
349521001145	aspartate racemase; Region: asp_race; TIGR00035
349521001146	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
349521001147	alpha-amylase; Reviewed; Region: malS; PRK09505
349521001148	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
349521001149	active site
349521001150	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
349521001151	active site
349521001152	catalytic site [active]
349521001153	catalytic site [active]
349521001154	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
349521001155	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521001156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521001157	dimer interface [polypeptide binding]; other site
349521001158	conserved gate region; other site
349521001159	putative PBP binding loops; other site
349521001160	ABC-ATPase subunit interface; other site
349521001161	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349521001162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521001163	dimer interface [polypeptide binding]; other site
349521001164	conserved gate region; other site
349521001165	putative PBP binding loops; other site
349521001166	ABC-ATPase subunit interface; other site
349521001167	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
349521001168	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
349521001169	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
349521001170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
349521001171	active site
349521001172	phosphorylation site [posttranslational modification]
349521001173	intermolecular recognition site; other site
349521001174	dimerization interface [polypeptide binding]; other site
349521001175	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521001176	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521001177	dimer interface [polypeptide binding]; other site
349521001178	putative CheW interface [polypeptide binding]; other site
349521001179	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349521001180	anti sigma factor interaction site; other site
349521001181	regulatory phosphorylation site [posttranslational modification]; other site
349521001182	Response regulator receiver domain; Region: Response_reg; pfam00072
349521001183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001184	active site
349521001185	phosphorylation site [posttranslational modification]
349521001186	intermolecular recognition site; other site
349521001187	dimerization interface [polypeptide binding]; other site
349521001188	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
349521001189	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
349521001190	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
349521001191	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349521001192	Response regulator receiver domain; Region: Response_reg; pfam00072
349521001193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001194	active site
349521001195	phosphorylation site [posttranslational modification]
349521001196	intermolecular recognition site; other site
349521001197	dimerization interface [polypeptide binding]; other site
349521001198	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
349521001199	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521001200	putative binding surface; other site
349521001201	active site
349521001202	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
349521001203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521001204	ATP binding site [chemical binding]; other site
349521001205	Mg2+ binding site [ion binding]; other site
349521001206	G-X-G motif; other site
349521001207	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
349521001208	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
349521001209	putative CheA interaction surface; other site
349521001210	PAS domain; Region: PAS_9; pfam13426
349521001211	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
349521001212	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521001213	dimer interface [polypeptide binding]; other site
349521001214	putative CheW interface [polypeptide binding]; other site
349521001215	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349521001216	PAS fold; Region: PAS; pfam00989
349521001217	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
349521001218	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521001219	dimer interface [polypeptide binding]; other site
349521001220	putative CheW interface [polypeptide binding]; other site
349521001221	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
349521001222	STAS domain; Region: STAS_2; pfam13466
349521001223	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
349521001224	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
349521001225	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
349521001226	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487
349521001227	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
349521001228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001229	active site
349521001230	phosphorylation site [posttranslational modification]
349521001231	intermolecular recognition site; other site
349521001232	dimerization interface [polypeptide binding]; other site
349521001233	CheB methylesterase; Region: CheB_methylest; pfam01339
349521001234	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
349521001235	transcriptional regulator protein; Region: phnR; TIGR03337
349521001236	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521001237	DNA-binding site [nucleotide binding]; DNA binding site
349521001238	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
349521001239	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521001240	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349521001241	active site
349521001242	metal binding site [ion binding]; metal-binding site
349521001243	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
349521001244	catalytic motif [active]
349521001245	Catalytic residue [active]
349521001246	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
349521001247	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521001248	RHS Repeat; Region: RHS_repeat; pfam05593
349521001249	RHS Repeat; Region: RHS_repeat; pfam05593
349521001250	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521001251	RHS Repeat; Region: RHS_repeat; pfam05593
349521001252	RHS Repeat; Region: RHS_repeat; pfam05593
349521001253	RHS Repeat; Region: RHS_repeat; pfam05593
349521001254	RHS Repeat; Region: RHS_repeat; pfam05593
349521001255	RHS protein; Region: RHS; pfam03527
349521001256	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521001257	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521001258	PAS domain; Region: PAS_9; pfam13426
349521001259	putative active site [active]
349521001260	heme pocket [chemical binding]; other site
349521001261	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521001262	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521001263	metal binding site [ion binding]; metal-binding site
349521001264	active site
349521001265	I-site; other site
349521001266	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521001267	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
349521001268	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
349521001269	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349521001270	Walker A/P-loop; other site
349521001271	ATP binding site [chemical binding]; other site
349521001272	Q-loop/lid; other site
349521001273	ABC transporter signature motif; other site
349521001274	Walker B; other site
349521001275	D-loop; other site
349521001276	H-loop/switch region; other site
349521001277	TOBE domain; Region: TOBE_2; pfam08402
349521001278	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
349521001279	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
349521001280	active site
349521001281	catalytic site [active]
349521001282	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
349521001283	transcriptional regulator MalT; Provisional; Region: PRK04841
349521001284	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521001285	DNA binding residues [nucleotide binding]
349521001286	dimerization interface [polypeptide binding]; other site
349521001287	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521001288	EamA-like transporter family; Region: EamA; pfam00892
349521001289	EamA-like transporter family; Region: EamA; pfam00892
349521001290	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
349521001291	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
349521001292	transmembrane helices; other site
349521001293	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
349521001294	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521001295	Coenzyme A binding pocket [chemical binding]; other site
349521001296	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
349521001297	Predicted permeases [General function prediction only]; Region: COG0679
349521001298	hypothetical protein; Provisional; Region: PRK13677
349521001299	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
349521001300	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
349521001301	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
349521001302	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
349521001303	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
349521001304	catalytic residues [active]
349521001305	dimer interface [polypeptide binding]; other site
349521001306	Protein of unknown function (DUF502); Region: DUF502; cl01107
349521001307	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
349521001308	PAS fold; Region: PAS_4; pfam08448
349521001309	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521001310	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521001311	metal binding site [ion binding]; metal-binding site
349521001312	active site
349521001313	I-site; other site
349521001314	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521001315	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
349521001316	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
349521001317	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
349521001318	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521001319	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521001320	dimer interface [polypeptide binding]; other site
349521001321	putative CheW interface [polypeptide binding]; other site
349521001322	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521001323	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521001324	metal binding site [ion binding]; metal-binding site
349521001325	active site
349521001326	I-site; other site
349521001327	Transcriptional regulators [Transcription]; Region: MarR; COG1846
349521001328	MarR family; Region: MarR; pfam01047
349521001329	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
349521001330	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
349521001331	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521001332	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521001333	metal binding site [ion binding]; metal-binding site
349521001334	active site
349521001335	I-site; other site
349521001336	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
349521001337	Low molecular weight phosphatase family; Region: LMWPc; cl00105
349521001338	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521001339	dimerization interface [polypeptide binding]; other site
349521001340	putative DNA binding site [nucleotide binding]; other site
349521001341	putative Zn2+ binding site [ion binding]; other site
349521001342	Low molecular weight phosphatase family; Region: LMWPc; cd00115
349521001343	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
349521001344	active site
349521001345	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
349521001346	arsenical-resistance protein; Region: acr3; TIGR00832
349521001347	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
349521001348	HAMP domain; Region: HAMP; pfam00672
349521001349	dimerization interface [polypeptide binding]; other site
349521001350	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521001351	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521001352	dimer interface [polypeptide binding]; other site
349521001353	putative CheW interface [polypeptide binding]; other site
349521001354	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521001355	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521001356	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521001357	putative effector binding pocket; other site
349521001358	dimerization interface [polypeptide binding]; other site
349521001359	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
349521001360	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521001361	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
349521001362	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521001363	Walker A/P-loop; other site
349521001364	ATP binding site [chemical binding]; other site
349521001365	Q-loop/lid; other site
349521001366	ABC transporter signature motif; other site
349521001367	Walker B; other site
349521001368	D-loop; other site
349521001369	H-loop/switch region; other site
349521001370	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
349521001371	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
349521001372	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
349521001373	active site residue [active]
349521001374	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
349521001375	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
349521001376	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
349521001377	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349521001378	HSP70 interaction site [polypeptide binding]; other site
349521001379	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
349521001380	substrate binding site [polypeptide binding]; other site
349521001381	dimer interface [polypeptide binding]; other site
349521001382	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
349521001383	dihydromonapterin reductase; Provisional; Region: PRK06483
349521001384	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521001385	NAD(P) binding site [chemical binding]; other site
349521001386	active site
349521001387	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
349521001388	homodecamer interface [polypeptide binding]; other site
349521001389	GTP cyclohydrolase I; Provisional; Region: PLN03044
349521001390	active site
349521001391	putative catalytic site residues [active]
349521001392	zinc binding site [ion binding]; other site
349521001393	GTP-CH-I/GFRP interaction surface; other site
349521001394	Predicted deacylase [General function prediction only]; Region: COG3608
349521001395	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
349521001396	putative active site [active]
349521001397	Zn binding site [ion binding]; other site
349521001398	Uncharacterized conserved protein [Function unknown]; Region: COG2968
349521001399	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
349521001400	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349521001401	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521001402	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521001403	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
349521001404	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
349521001405	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
349521001406	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
349521001407	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521001408	ABC-ATPase subunit  interface; other site
349521001409	dimer interface [polypeptide binding]; other site
349521001410	putative PBP binding regions; other site
349521001411	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
349521001412	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
349521001413	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
349521001414	metal binding site 2 [ion binding]; metal-binding site
349521001415	putative DNA binding helix; other site
349521001416	metal binding site 1 [ion binding]; metal-binding site
349521001417	dimer interface [polypeptide binding]; other site
349521001418	structural Zn2+ binding site [ion binding]; other site
349521001419	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
349521001420	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521001421	CheW-like domain; Region: CheW; pfam01584
349521001422	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
349521001423	CheB methylesterase; Region: CheB_methylest; pfam01339
349521001424	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521001425	putative binding surface; other site
349521001426	active site
349521001427	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521001428	putative binding surface; other site
349521001429	active site
349521001430	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521001431	putative binding surface; other site
349521001432	active site
349521001433	Hpt domain; Region: Hpt; pfam01627
349521001434	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521001435	putative binding surface; other site
349521001436	active site
349521001437	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521001438	putative binding surface; other site
349521001439	active site
349521001440	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521001441	putative binding surface; other site
349521001442	active site
349521001443	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
349521001444	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521001445	putative binding surface; other site
349521001446	active site
349521001447	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
349521001448	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
349521001449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521001450	ATP binding site [chemical binding]; other site
349521001451	Mg2+ binding site [ion binding]; other site
349521001452	G-X-G motif; other site
349521001453	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
349521001454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001455	Response regulator receiver domain; Region: Response_reg; pfam00072
349521001456	active site
349521001457	phosphorylation site [posttranslational modification]
349521001458	intermolecular recognition site; other site
349521001459	dimerization interface [polypeptide binding]; other site
349521001460	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
349521001461	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
349521001462	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
349521001463	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
349521001464	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521001465	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521001466	dimer interface [polypeptide binding]; other site
349521001467	putative CheW interface [polypeptide binding]; other site
349521001468	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
349521001469	Response regulator receiver domain; Region: Response_reg; pfam00072
349521001470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001471	active site
349521001472	phosphorylation site [posttranslational modification]
349521001473	intermolecular recognition site; other site
349521001474	dimerization interface [polypeptide binding]; other site
349521001475	Response regulator receiver domain; Region: Response_reg; pfam00072
349521001476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001477	active site
349521001478	phosphorylation site [posttranslational modification]
349521001479	intermolecular recognition site; other site
349521001480	dimerization interface [polypeptide binding]; other site
349521001481	glutathione synthetase; Provisional; Region: PRK05246
349521001482	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
349521001483	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
349521001484	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
349521001485	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
349521001486	hypothetical protein; Validated; Region: PRK00228
349521001487	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
349521001488	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
349521001489	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521001490	active site
349521001491	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
349521001492	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
349521001493	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
349521001494	dihydroorotase; Validated; Region: pyrC; PRK09357
349521001495	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349521001496	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
349521001497	active site
349521001498	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
349521001499	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
349521001500	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349521001501	IHF dimer interface [polypeptide binding]; other site
349521001502	IHF - DNA interface [nucleotide binding]; other site
349521001503	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
349521001504	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
349521001505	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
349521001506	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
349521001507	active site
349521001508	substrate-binding site [chemical binding]; other site
349521001509	metal-binding site [ion binding]
349521001510	ATP binding site [chemical binding]; other site
349521001511	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
349521001512	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
349521001513	dimerization interface [polypeptide binding]; other site
349521001514	domain crossover interface; other site
349521001515	redox-dependent activation switch; other site
349521001516	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349521001517	RNA binding surface [nucleotide binding]; other site
349521001518	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
349521001519	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521001520	motif II; other site
349521001521	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349521001522	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
349521001523	active site
349521001524	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
349521001525	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
349521001526	DNA binding site [nucleotide binding]
349521001527	catalytic residue [active]
349521001528	H2TH interface [polypeptide binding]; other site
349521001529	putative catalytic residues [active]
349521001530	turnover-facilitating residue; other site
349521001531	intercalation triad [nucleotide binding]; other site
349521001532	8OG recognition residue [nucleotide binding]; other site
349521001533	putative reading head residues; other site
349521001534	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
349521001535	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
349521001536	Fatty acid desaturase; Region: FA_desaturase; pfam00487
349521001537	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
349521001538	Di-iron ligands [ion binding]; other site
349521001539	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
349521001540	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521001541	S-adenosylmethionine binding site [chemical binding]; other site
349521001542	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
349521001543	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
349521001544	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
349521001545	P loop; other site
349521001546	GTP binding site [chemical binding]; other site
349521001547	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
349521001548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521001549	Walker A/P-loop; other site
349521001550	ATP binding site [chemical binding]; other site
349521001551	Q-loop/lid; other site
349521001552	ABC transporter signature motif; other site
349521001553	Walker B; other site
349521001554	D-loop; other site
349521001555	H-loop/switch region; other site
349521001556	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
349521001557	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
349521001558	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
349521001559	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349521001560	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521001561	DNA binding residues [nucleotide binding]
349521001562	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
349521001563	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349521001564	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
349521001565	Protein of unknown function (DUF1762); Region: DUF1762; pfam08574
349521001566	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
349521001567	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
349521001568	putative metal binding site [ion binding]; other site
349521001569	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349521001570	HSP70 interaction site [polypeptide binding]; other site
349521001571	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521001572	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001573	active site
349521001574	phosphorylation site [posttranslational modification]
349521001575	intermolecular recognition site; other site
349521001576	dimerization interface [polypeptide binding]; other site
349521001577	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521001578	DNA binding site [nucleotide binding]
349521001579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521001580	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521001581	dimerization interface [polypeptide binding]; other site
349521001582	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521001583	dimer interface [polypeptide binding]; other site
349521001584	phosphorylation site [posttranslational modification]
349521001585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521001586	ATP binding site [chemical binding]; other site
349521001587	Mg2+ binding site [ion binding]; other site
349521001588	G-X-G motif; other site
349521001589	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521001590	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521001591	WHG domain; Region: WHG; pfam13305
349521001592	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
349521001593	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
349521001594	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
349521001595	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
349521001596	Acyl CoA binding protein; Region: ACBP; pfam00887
349521001597	acyl-CoA binding pocket [chemical binding]; other site
349521001598	CoA binding site [chemical binding]; other site
349521001599	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349521001600	CoenzymeA binding site [chemical binding]; other site
349521001601	subunit interaction site [polypeptide binding]; other site
349521001602	PHB binding site; other site
349521001603	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
349521001604	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521001605	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521001606	Walker A/P-loop; other site
349521001607	ATP binding site [chemical binding]; other site
349521001608	Q-loop/lid; other site
349521001609	ABC transporter signature motif; other site
349521001610	Walker B; other site
349521001611	D-loop; other site
349521001612	H-loop/switch region; other site
349521001613	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
349521001614	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
349521001615	Part of AAA domain; Region: AAA_19; pfam13245
349521001616	Family description; Region: UvrD_C_2; pfam13538
349521001617	Abortive infection C-terminus; Region: Abi_C; pfam14355
349521001618	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521001619	sequence-specific DNA binding site [nucleotide binding]; other site
349521001620	salt bridge; other site
349521001621	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
349521001622	Catalytic site [active]
349521001623	DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744
349521001624	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
349521001625	Replication protein P; Region: Phage_lambda_P; pfam06992
349521001626	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521001627	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349521001628	Homeodomain-like domain; Region: HTH_23; pfam13384
349521001629	Winged helix-turn helix; Region: HTH_29; pfam13551
349521001630	Homeodomain-like domain; Region: HTH_32; pfam13565
349521001631	Tetratricopeptide repeat; Region: TPR_12; pfam13424
349521001632	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521001633	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
349521001634	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
349521001635	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
349521001636	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521001637	Cadherin repeat-like domain; Region: CA_like; cl15786
349521001638	Ca2+ binding site [ion binding]; other site
349521001639	Cadherin repeat-like domain; Region: CA_like; cl15786
349521001640	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521001641	Ca2+ binding site [ion binding]; other site
349521001642	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
349521001643	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521001644	Cadherin repeat-like domain; Region: CA_like; cl15786
349521001645	Ca2+ binding site [ion binding]; other site
349521001646	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521001647	Cadherin repeat-like domain; Region: CA_like; cl15786
349521001648	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
349521001649	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
349521001650	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
349521001651	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
349521001652	MPN+ (JAMM) motif; other site
349521001653	Zinc-binding site [ion binding]; other site
349521001654	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
349521001655	integrase; Provisional; Region: PRK09692
349521001656	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
349521001657	active site
349521001658	Int/Topo IB signature motif; other site
349521001659	Rdx family; Region: Rdx; cl01407
349521001660	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521001661	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349521001662	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521001663	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349521001664	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521001665	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521001666	putative active site [active]
349521001667	heme pocket [chemical binding]; other site
349521001668	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521001669	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521001670	metal binding site [ion binding]; metal-binding site
349521001671	active site
349521001672	I-site; other site
349521001673	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
349521001674	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
349521001675	hypothetical protein; Provisional; Region: PRK05409
349521001676	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
349521001677	Protein of unknown function (DUF796); Region: DUF796; pfam05638
349521001678	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521001679	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521001680	active site
349521001681	ATP binding site [chemical binding]; other site
349521001682	substrate binding site [chemical binding]; other site
349521001683	activation loop (A-loop); other site
349521001684	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349521001685	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349521001686	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
349521001687	putative ligand binding site [chemical binding]; other site
349521001688	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349521001689	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
349521001690	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
349521001691	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521001692	substrate binding site [chemical binding]; other site
349521001693	oxyanion hole (OAH) forming residues; other site
349521001694	trimer interface [polypeptide binding]; other site
349521001695	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
349521001696	enoyl-CoA hydratase; Provisional; Region: PRK09076
349521001697	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521001698	substrate binding site [chemical binding]; other site
349521001699	oxyanion hole (OAH) forming residues; other site
349521001700	trimer interface [polypeptide binding]; other site
349521001701	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349521001702	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
349521001703	substrate binding pocket [chemical binding]; other site
349521001704	FAD binding site [chemical binding]; other site
349521001705	catalytic base [active]
349521001706	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
349521001707	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
349521001708	tetrameric interface [polypeptide binding]; other site
349521001709	NAD binding site [chemical binding]; other site
349521001710	catalytic residues [active]
349521001711	Uncharacterized conserved protein [Function unknown]; Region: COG1434
349521001712	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
349521001713	putative active site [active]
349521001714	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521001715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001716	active site
349521001717	phosphorylation site [posttranslational modification]
349521001718	intermolecular recognition site; other site
349521001719	dimerization interface [polypeptide binding]; other site
349521001720	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521001721	TPR motif; other site
349521001722	binding surface
349521001723	TPR repeat; Region: TPR_11; pfam13414
349521001724	ferrochelatase; Reviewed; Region: hemH; PRK00035
349521001725	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
349521001726	C-terminal domain interface [polypeptide binding]; other site
349521001727	active site
349521001728	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
349521001729	active site
349521001730	N-terminal domain interface [polypeptide binding]; other site
349521001731	Cytochrome c553 [Energy production and conversion]; Region: COG2863
349521001732	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
349521001733	Helix-turn-helix domain; Region: HTH_18; pfam12833
349521001734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521001735	Predicted esterase [General function prediction only]; Region: COG0400
349521001736	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
349521001737	dimer interface [polypeptide binding]; other site
349521001738	active site
349521001739	Schiff base residues; other site
349521001740	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
349521001741	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
349521001742	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
349521001743	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
349521001744	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
349521001745	Ligand Binding Site [chemical binding]; other site
349521001746	thiazole biosynthesis domain; Region: ThiI_C_thiazole; TIGR04271
349521001747	active site residue [active]
349521001748	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521001749	Zn2+ binding site [ion binding]; other site
349521001750	Mg2+ binding site [ion binding]; other site
349521001751	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
349521001752	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
349521001753	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349521001754	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349521001755	Walker A/P-loop; other site
349521001756	ATP binding site [chemical binding]; other site
349521001757	Q-loop/lid; other site
349521001758	ABC transporter signature motif; other site
349521001759	Walker B; other site
349521001760	D-loop; other site
349521001761	H-loop/switch region; other site
349521001762	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349521001763	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
349521001764	FtsX-like permease family; Region: FtsX; pfam02687
349521001765	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
349521001766	Serine hydrolase; Region: Ser_hydrolase; cl17834
349521001767	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
349521001768	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
349521001769	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521001770	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521001771	metal binding site [ion binding]; metal-binding site
349521001772	active site
349521001773	I-site; other site
349521001774	Cytochrome c; Region: Cytochrom_C; pfam00034
349521001775	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521001776	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521001777	substrate binding pocket [chemical binding]; other site
349521001778	membrane-bound complex binding site; other site
349521001779	hinge residues; other site
349521001780	Protein of unknown function, DUF479; Region: DUF479; cl01203
349521001781	Response regulator receiver domain; Region: Response_reg; pfam00072
349521001782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001783	active site
349521001784	phosphorylation site [posttranslational modification]
349521001785	intermolecular recognition site; other site
349521001786	dimerization interface [polypeptide binding]; other site
349521001787	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
349521001788	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349521001789	PAS domain; Region: PAS_9; pfam13426
349521001790	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521001791	ATP binding site [chemical binding]; other site
349521001792	Mg2+ binding site [ion binding]; other site
349521001793	G-X-G motif; other site
349521001794	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
349521001795	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521001796	TPR motif; other site
349521001797	binding surface
349521001798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521001799	binding surface
349521001800	TPR motif; other site
349521001801	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
349521001802	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
349521001803	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
349521001804	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521001805	active site
349521001806	MgtC family; Region: MgtC; pfam02308
349521001807	OmpW family; Region: OmpW; cl17427
349521001808	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
349521001809	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
349521001810	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
349521001811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521001812	dimer interface [polypeptide binding]; other site
349521001813	phosphorylation site [posttranslational modification]
349521001814	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
349521001815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521001816	ATP binding site [chemical binding]; other site
349521001817	Mg2+ binding site [ion binding]; other site
349521001818	G-X-G motif; other site
349521001819	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349521001820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521001821	active site
349521001822	phosphorylation site [posttranslational modification]
349521001823	intermolecular recognition site; other site
349521001824	dimerization interface [polypeptide binding]; other site
349521001825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521001826	Walker A motif; other site
349521001827	ATP binding site [chemical binding]; other site
349521001828	Walker B motif; other site
349521001829	arginine finger; other site
349521001830	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521001831	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
349521001832	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
349521001833	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521001834	Walker A/P-loop; other site
349521001835	ATP binding site [chemical binding]; other site
349521001836	Q-loop/lid; other site
349521001837	ABC transporter signature motif; other site
349521001838	Walker B; other site
349521001839	D-loop; other site
349521001840	H-loop/switch region; other site
349521001841	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
349521001842	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
349521001843	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521001844	Walker A/P-loop; other site
349521001845	ATP binding site [chemical binding]; other site
349521001846	Q-loop/lid; other site
349521001847	ABC transporter signature motif; other site
349521001848	Walker B; other site
349521001849	D-loop; other site
349521001850	H-loop/switch region; other site
349521001851	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
349521001852	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
349521001853	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
349521001854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521001855	dimer interface [polypeptide binding]; other site
349521001856	conserved gate region; other site
349521001857	putative PBP binding loops; other site
349521001858	ABC-ATPase subunit interface; other site
349521001859	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
349521001860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521001861	dimer interface [polypeptide binding]; other site
349521001862	conserved gate region; other site
349521001863	putative PBP binding loops; other site
349521001864	ABC-ATPase subunit interface; other site
349521001865	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
349521001866	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
349521001867	peptide binding site [polypeptide binding]; other site
349521001868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349521001869	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
349521001870	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521001871	catalytic residue [active]
349521001872	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
349521001873	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521001874	DNA-binding site [nucleotide binding]; DNA binding site
349521001875	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521001876	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521001877	homodimer interface [polypeptide binding]; other site
349521001878	catalytic residue [active]
349521001879	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521001880	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521001881	substrate binding pocket [chemical binding]; other site
349521001882	membrane-bound complex binding site; other site
349521001883	hinge residues; other site
349521001884	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521001885	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521001886	substrate binding pocket [chemical binding]; other site
349521001887	membrane-bound complex binding site; other site
349521001888	hinge residues; other site
349521001889	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521001890	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
349521001891	Predicted transcriptional regulators [Transcription]; Region: COG1733
349521001892	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
349521001893	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
349521001894	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
349521001895	Hemerythrin-like domain; Region: Hr-like; cd12108
349521001896	Fe binding site [ion binding]; other site
349521001897	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
349521001898	GAF domain; Region: GAF; pfam01590
349521001899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521001900	Walker A motif; other site
349521001901	ATP binding site [chemical binding]; other site
349521001902	Walker B motif; other site
349521001903	arginine finger; other site
349521001904	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
349521001905	Viral methyltransferase C-terminal; Region: Vmethyltransf_C; pfam08456
349521001906	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521001907	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
349521001908	classical (c) SDRs; Region: SDR_c; cd05233
349521001909	NAD(P) binding site [chemical binding]; other site
349521001910	active site
349521001911	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
349521001912	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
349521001913	dimerization interface [polypeptide binding]; other site
349521001914	NAD binding site [chemical binding]; other site
349521001915	ligand binding site [chemical binding]; other site
349521001916	catalytic site [active]
349521001917	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
349521001918	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
349521001919	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
349521001920	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
349521001921	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
349521001922	NAD(P) binding site [chemical binding]; other site
349521001923	catalytic residues [active]
349521001924	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
349521001925	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
349521001926	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145
349521001927	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
349521001928	Domain of unknown function (DUF427); Region: DUF427; pfam04248
349521001929	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521001930	putative binding surface; other site
349521001931	active site
349521001932	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521001933	Zn2+ binding site [ion binding]; other site
349521001934	Mg2+ binding site [ion binding]; other site
349521001935	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
349521001936	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
349521001937	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
349521001938	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
349521001939	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
349521001940	putative active site [active]
349521001941	Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477
349521001942	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
349521001943	PAS fold; Region: PAS_3; pfam08447
349521001944	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521001945	PAS domain; Region: PAS_9; pfam13426
349521001946	putative active site [active]
349521001947	heme pocket [chemical binding]; other site
349521001948	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521001949	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521001950	metal binding site [ion binding]; metal-binding site
349521001951	active site
349521001952	I-site; other site
349521001953	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521001954	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
349521001955	Part of AAA domain; Region: AAA_19; pfam13245
349521001956	Family description; Region: UvrD_C_2; pfam13538
349521001957	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
349521001958	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
349521001959	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
349521001960	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
349521001961	DctM-like transporters; Region: DctM; pfam06808
349521001962	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
349521001963	PBP superfamily domain; Region: PBP_like_2; cl17296
349521001964	TIGR03545 family protein; Region: TIGR03545
349521001965	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
349521001966	coenzyme F420 hydrogenase, subunit alpha; Region: frhA; TIGR03295
349521001967	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
349521001968	structural tetrad; other site
349521001969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521001970	ABC-ATPase subunit interface; other site
349521001971	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
349521001972	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
349521001973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521001974	dimer interface [polypeptide binding]; other site
349521001975	conserved gate region; other site
349521001976	putative PBP binding loops; other site
349521001977	ABC-ATPase subunit interface; other site
349521001978	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
349521001979	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
349521001980	Walker A/P-loop; other site
349521001981	ATP binding site [chemical binding]; other site
349521001982	Q-loop/lid; other site
349521001983	ABC transporter signature motif; other site
349521001984	Walker B; other site
349521001985	D-loop; other site
349521001986	H-loop/switch region; other site
349521001987	transcriptional regulator PhoU; Provisional; Region: PRK11115
349521001988	PhoU domain; Region: PhoU; pfam01895
349521001989	PhoU domain; Region: PhoU; pfam01895
349521001990	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
349521001991	putative active site pocket [active]
349521001992	dimerization interface [polypeptide binding]; other site
349521001993	putative catalytic residue [active]
349521001994	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
349521001995	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
349521001996	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
349521001997	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
349521001998	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349521001999	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
349521002000	nucleophilic elbow; other site
349521002001	catalytic triad; other site
349521002002	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
349521002003	nucleotide binding site/active site [active]
349521002004	HIT family signature motif; other site
349521002005	catalytic residue [active]
349521002006	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
349521002007	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
349521002008	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521002009	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521002010	substrate binding pocket [chemical binding]; other site
349521002011	membrane-bound complex binding site; other site
349521002012	hinge residues; other site
349521002013	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
349521002014	putative deacylase active site [active]
349521002015	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
349521002016	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521002017	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521002018	ligand binding site [chemical binding]; other site
349521002019	mechanosensitive channel MscS; Provisional; Region: PRK10334
349521002020	Mechanosensitive ion channel; Region: MS_channel; pfam00924
349521002021	Predicted methyltransferase [General function prediction only]; Region: COG3897
349521002022	Predicted integral membrane protein [Function unknown]; Region: COG5652
349521002023	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
349521002024	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
349521002025	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521002026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002027	active site
349521002028	phosphorylation site [posttranslational modification]
349521002029	intermolecular recognition site; other site
349521002030	dimerization interface [polypeptide binding]; other site
349521002031	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
349521002032	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349521002033	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349521002034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521002035	dimer interface [polypeptide binding]; other site
349521002036	phosphorylation site [posttranslational modification]
349521002037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521002038	ATP binding site [chemical binding]; other site
349521002039	Mg2+ binding site [ion binding]; other site
349521002040	G-X-G motif; other site
349521002041	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
349521002042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002043	active site
349521002044	phosphorylation site [posttranslational modification]
349521002045	intermolecular recognition site; other site
349521002046	dimerization interface [polypeptide binding]; other site
349521002047	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521002048	DNA binding site [nucleotide binding]
349521002049	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
349521002050	UbiA prenyltransferase family; Region: UbiA; pfam01040
349521002051	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
349521002052	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
349521002053	TrkA-N domain; Region: TrkA_N; pfam02254
349521002054	TrkA-C domain; Region: TrkA_C; pfam02080
349521002055	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521002056	active site
349521002057	Rubredoxin [Energy production and conversion]; Region: COG1773
349521002058	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
349521002059	iron binding site [ion binding]; other site
349521002060	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
349521002061	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521002062	hypothetical protein; Provisional; Region: PRK07236
349521002063	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
349521002064	RimK-like ATP-grasp domain; Region: RimK; pfam08443
349521002065	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521002066	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521002067	ligand binding site [chemical binding]; other site
349521002068	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
349521002069	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
349521002070	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
349521002071	active site
349521002072	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
349521002073	catalytic triad [active]
349521002074	dimer interface [polypeptide binding]; other site
349521002075	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
349521002076	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
349521002077	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
349521002078	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
349521002079	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521002080	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521002081	metal binding site [ion binding]; metal-binding site
349521002082	active site
349521002083	I-site; other site
349521002084	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521002085	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
349521002086	EVE domain; Region: EVE; pfam01878
349521002087	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521002088	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521002089	metal binding site [ion binding]; metal-binding site
349521002090	active site
349521002091	I-site; other site
349521002092	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
349521002093	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
349521002094	Phosphate transporter family; Region: PHO4; cl00396
349521002095	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
349521002096	Protein of unknown function, DUF488; Region: DUF488; pfam04343
349521002097	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
349521002098	Cupin domain; Region: Cupin_2; cl17218
349521002099	PAS domain S-box; Region: sensory_box; TIGR00229
349521002100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521002101	putative active site [active]
349521002102	heme pocket [chemical binding]; other site
349521002103	PAS domain; Region: PAS_9; pfam13426
349521002104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521002105	putative active site [active]
349521002106	heme pocket [chemical binding]; other site
349521002107	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521002108	PAS fold; Region: PAS_3; pfam08447
349521002109	putative active site [active]
349521002110	heme pocket [chemical binding]; other site
349521002111	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521002112	dimer interface [polypeptide binding]; other site
349521002113	phosphorylation site [posttranslational modification]
349521002114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521002115	ATP binding site [chemical binding]; other site
349521002116	Mg2+ binding site [ion binding]; other site
349521002117	G-X-G motif; other site
349521002118	Response regulator receiver domain; Region: Response_reg; pfam00072
349521002119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002120	active site
349521002121	phosphorylation site [posttranslational modification]
349521002122	intermolecular recognition site; other site
349521002123	dimerization interface [polypeptide binding]; other site
349521002124	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521002125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002126	active site
349521002127	phosphorylation site [posttranslational modification]
349521002128	intermolecular recognition site; other site
349521002129	dimerization interface [polypeptide binding]; other site
349521002130	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521002131	putative binding surface; other site
349521002132	active site
349521002133	hypothetical protein; Provisional; Region: PRK01254
349521002134	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
349521002135	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
349521002136	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
349521002137	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
349521002138	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
349521002139	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
349521002140	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349521002141	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
349521002142	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
349521002143	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349521002144	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
349521002145	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
349521002146	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
349521002147	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
349521002148	active site
349521002149	zinc binding site [ion binding]; other site
349521002150	Chitin binding domain; Region: Chitin_bind_3; pfam03067
349521002151	Cellulose binding domain; Region: CBM_2; pfam00553
349521002152	short chain dehydrogenase; Provisional; Region: PRK06123
349521002153	classical (c) SDRs; Region: SDR_c; cd05233
349521002154	NAD(P) binding site [chemical binding]; other site
349521002155	active site
349521002156	CHASE domain; Region: CHASE; cl01369
349521002157	PAS domain S-box; Region: sensory_box; TIGR00229
349521002158	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521002159	putative active site [active]
349521002160	heme pocket [chemical binding]; other site
349521002161	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
349521002162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521002163	putative active site [active]
349521002164	heme pocket [chemical binding]; other site
349521002165	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521002166	dimer interface [polypeptide binding]; other site
349521002167	phosphorylation site [posttranslational modification]
349521002168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521002169	ATP binding site [chemical binding]; other site
349521002170	Mg2+ binding site [ion binding]; other site
349521002171	G-X-G motif; other site
349521002172	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521002173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002174	active site
349521002175	phosphorylation site [posttranslational modification]
349521002176	intermolecular recognition site; other site
349521002177	dimerization interface [polypeptide binding]; other site
349521002178	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521002179	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002180	active site
349521002181	phosphorylation site [posttranslational modification]
349521002182	intermolecular recognition site; other site
349521002183	dimerization interface [polypeptide binding]; other site
349521002184	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521002185	putative binding surface; other site
349521002186	active site
349521002187	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
349521002188	oligomerization interface [polypeptide binding]; other site
349521002189	active site
349521002190	metal binding site [ion binding]; metal-binding site
349521002191	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
349521002192	active site
349521002193	catalytic site [active]
349521002194	substrate binding site [chemical binding]; other site
349521002195	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653
349521002196	Active_site [active]
349521002197	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521002198	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
349521002199	HD domain; Region: HD_3; pfam13023
349521002200	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
349521002201	Uncharacterized conserved protein [Function unknown]; Region: COG4278
349521002202	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521002203	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
349521002204	substrate binding pocket [chemical binding]; other site
349521002205	membrane-bound complex binding site; other site
349521002206	hinge residues; other site
349521002207	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349521002208	CoenzymeA binding site [chemical binding]; other site
349521002209	subunit interaction site [polypeptide binding]; other site
349521002210	PHB binding site; other site
349521002211	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
349521002212	active site
349521002213	catalytic triad [active]
349521002214	oxyanion hole [active]
349521002215	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521002216	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349521002217	Helix-turn-helix domain; Region: HTH_18; pfam12833
349521002218	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
349521002219	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
349521002220	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
349521002221	active site
349521002222	Zn binding site [ion binding]; other site
349521002223	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
349521002224	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
349521002225	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521002226	motif II; other site
349521002227	Pectate lyase; Region: Pectate_lyase; pfam03211
349521002228	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
349521002229	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
349521002230	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
349521002231	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
349521002232	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
349521002233	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
349521002234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
349521002235	Histidine kinase; Region: HisKA_3; pfam07730
349521002236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521002237	ATP binding site [chemical binding]; other site
349521002238	Mg2+ binding site [ion binding]; other site
349521002239	G-X-G motif; other site
349521002240	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521002241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349521002242	Homeodomain-like domain; Region: HTH_23; pfam13384
349521002243	Winged helix-turn helix; Region: HTH_29; pfam13551
349521002244	Homeodomain-like domain; Region: HTH_32; pfam13565
349521002245	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349521002246	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
349521002247	conserved cys residue [active]
349521002248	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521002249	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521002250	Lipase (class 2); Region: Lipase_2; pfam01674
349521002251	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521002252	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
349521002253	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349521002254	molybdopterin cofactor binding site; other site
349521002255	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
349521002256	putative molybdopterin cofactor binding site; other site
349521002257	Predicted transcriptional regulators [Transcription]; Region: COG1733
349521002258	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
349521002259	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
349521002260	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521002261	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
349521002262	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
349521002263	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
349521002264	tetrameric interface [polypeptide binding]; other site
349521002265	NAD binding site [chemical binding]; other site
349521002266	catalytic residues [active]
349521002267	choline dehydrogenase; Validated; Region: PRK02106
349521002268	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
349521002269	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
349521002270	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
349521002271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521002272	dimer interface [polypeptide binding]; other site
349521002273	conserved gate region; other site
349521002274	putative PBP binding loops; other site
349521002275	ABC-ATPase subunit interface; other site
349521002276	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
349521002277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521002278	Walker A/P-loop; other site
349521002279	ATP binding site [chemical binding]; other site
349521002280	Q-loop/lid; other site
349521002281	ABC transporter signature motif; other site
349521002282	Walker B; other site
349521002283	D-loop; other site
349521002284	H-loop/switch region; other site
349521002285	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
349521002286	Protein of unknown function (DUF975); Region: DUF975; cl10504
349521002287	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
349521002288	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
349521002289	tetramer interface [polypeptide binding]; other site
349521002290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521002291	catalytic residue [active]
349521002292	HAMP domain; Region: HAMP; pfam00672
349521002293	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
349521002294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521002295	dimer interface [polypeptide binding]; other site
349521002296	phosphorylation site [posttranslational modification]
349521002297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521002298	ATP binding site [chemical binding]; other site
349521002299	Mg2+ binding site [ion binding]; other site
349521002300	G-X-G motif; other site
349521002301	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521002302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002303	active site
349521002304	phosphorylation site [posttranslational modification]
349521002305	intermolecular recognition site; other site
349521002306	dimerization interface [polypeptide binding]; other site
349521002307	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521002308	putative binding surface; other site
349521002309	active site
349521002310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002311	active site
349521002312	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
349521002313	phosphorylation site [posttranslational modification]
349521002314	intermolecular recognition site; other site
349521002315	dimerization interface [polypeptide binding]; other site
349521002316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002317	active site
349521002318	phosphorylation site [posttranslational modification]
349521002319	intermolecular recognition site; other site
349521002320	dimerization interface [polypeptide binding]; other site
349521002321	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521002322	metal binding site [ion binding]; metal-binding site
349521002323	active site
349521002324	I-site; other site
349521002325	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
349521002326	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
349521002327	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
349521002328	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
349521002329	putative MFS family transporter protein; Provisional; Region: PRK03633
349521002330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521002331	putative substrate translocation pore; other site
349521002332	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
349521002333	aromatic chitin/cellulose binding site residues [chemical binding]; other site
349521002334	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
349521002335	aromatic chitin/cellulose binding site residues [chemical binding]; other site
349521002336	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
349521002337	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
349521002338	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
349521002339	putative active site [active]
349521002340	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
349521002341	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
349521002342	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
349521002343	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349521002344	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521002345	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349521002346	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
349521002347	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
349521002348	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
349521002349	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521002350	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521002351	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
349521002352	Predicted membrane protein [Function unknown]; Region: COG4392
349521002353	CARDB; Region: CARDB; pfam07705
349521002354	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
349521002355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
349521002356	ATP binding site [chemical binding]; other site
349521002357	DEAD_2; Region: DEAD_2; pfam06733
349521002358	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
349521002359	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
349521002360	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349521002361	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
349521002362	conserved cys residue [active]
349521002363	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521002364	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521002365	SdiA-regulated; Region: SdiA-regulated; cd09971
349521002366	putative active site [active]
349521002367	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
349521002368	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521002369	substrate binding pocket [chemical binding]; other site
349521002370	membrane-bound complex binding site; other site
349521002371	hinge residues; other site
349521002372	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
349521002373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521002374	dimer interface [polypeptide binding]; other site
349521002375	conserved gate region; other site
349521002376	putative PBP binding loops; other site
349521002377	ABC-ATPase subunit interface; other site
349521002378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521002379	dimer interface [polypeptide binding]; other site
349521002380	conserved gate region; other site
349521002381	putative PBP binding loops; other site
349521002382	ABC-ATPase subunit interface; other site
349521002383	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
349521002384	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
349521002385	Walker A/P-loop; other site
349521002386	ATP binding site [chemical binding]; other site
349521002387	Q-loop/lid; other site
349521002388	ABC transporter signature motif; other site
349521002389	Walker B; other site
349521002390	D-loop; other site
349521002391	H-loop/switch region; other site
349521002392	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
349521002393	metal ion-dependent adhesion site (MIDAS); other site
349521002394	Protein phosphatase 2C; Region: PP2C_2; pfam13672
349521002395	Protein kinase domain; Region: Pkinase; pfam00069
349521002396	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349521002397	active site
349521002398	ATP binding site [chemical binding]; other site
349521002399	substrate binding site [chemical binding]; other site
349521002400	activation loop (A-loop); other site
349521002401	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349521002402	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
349521002403	Putative Ig domain; Region: He_PIG; pfam05345
349521002404	Right handed beta helix region; Region: Beta_helix; pfam13229
349521002405	exonuclease subunit SbcD; Provisional; Region: PRK10966
349521002406	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
349521002407	active site
349521002408	metal binding site [ion binding]; metal-binding site
349521002409	DNA binding site [nucleotide binding]
349521002410	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
349521002411	exonuclease subunit SbcC; Provisional; Region: PRK10246
349521002412	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521002413	Walker A/P-loop; other site
349521002414	ATP binding site [chemical binding]; other site
349521002415	Q-loop/lid; other site
349521002416	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521002417	ABC transporter signature motif; other site
349521002418	Walker B; other site
349521002419	D-loop; other site
349521002420	H-loop/switch region; other site
349521002421	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
349521002422	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324
349521002423	putative ligand binding site [chemical binding]; other site
349521002424	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349521002425	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349521002426	conjugal transfer protein TrbH; Provisional; Region: PRK13883
349521002427	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521002428	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521002429	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521002430	putative effector binding pocket; other site
349521002431	dimerization interface [polypeptide binding]; other site
349521002432	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521002433	YaeQ protein; Region: YaeQ; pfam07152
349521002434	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521002435	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
349521002436	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
349521002437	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521002438	active site
349521002439	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
349521002440	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
349521002441	ATP synthase; Region: ATP-synt; pfam00231
349521002442	core domain interface [polypeptide binding]; other site
349521002443	delta subunit interface [polypeptide binding]; other site
349521002444	epsilon subunit interface [polypeptide binding]; other site
349521002445	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
349521002446	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349521002447	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349521002448	Walker A motif; other site
349521002449	ATP binding site [chemical binding]; other site
349521002450	Walker B motif; other site
349521002451	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
349521002452	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
349521002453	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
349521002454	ATP synthase subunit C; Region: ATP-synt_C; cl00466
349521002455	F0F1 ATP synthase subunit A; Provisional; Region: PRK13420
349521002456	alternate F1F0 ATPase, F1 subunit epsilon; Region: alt_F1F0_F1_eps; TIGR03166
349521002457	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033
349521002458	epsilon subunit interface [polypeptide binding]; other site
349521002459	LBP interface [polypeptide binding]; other site
349521002460	gamma subunit interface [polypeptide binding]; other site
349521002461	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
349521002462	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
349521002463	alpha subunit interaction interface [polypeptide binding]; other site
349521002464	Walker A motif; other site
349521002465	ATP binding site [chemical binding]; other site
349521002466	Walker B motif; other site
349521002467	inhibitor binding site; inhibition site
349521002468	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
349521002469	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
349521002470	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349521002471	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349521002472	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521002473	dimer interface [polypeptide binding]; other site
349521002474	phosphorylation site [posttranslational modification]
349521002475	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521002476	ATP binding site [chemical binding]; other site
349521002477	Mg2+ binding site [ion binding]; other site
349521002478	G-X-G motif; other site
349521002479	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349521002480	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002481	active site
349521002482	phosphorylation site [posttranslational modification]
349521002483	intermolecular recognition site; other site
349521002484	dimerization interface [polypeptide binding]; other site
349521002485	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521002486	Walker A motif; other site
349521002487	ATP binding site [chemical binding]; other site
349521002488	Walker B motif; other site
349521002489	arginine finger; other site
349521002490	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
349521002491	SnoaL-like domain; Region: SnoaL_2; pfam12680
349521002492	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
349521002493	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
349521002494	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
349521002495	DctM-like transporters; Region: DctM; pfam06808
349521002496	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
349521002497	Protein of unknown function (DUF770); Region: DUF770; cl01402
349521002498	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
349521002499	Protein of unknown function (DUF877); Region: DUF877; pfam05943
349521002500	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521002501	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
349521002502	putative active site [active]
349521002503	putative metal binding site [ion binding]; other site
349521002504	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
349521002505	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
349521002506	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521002507	Coenzyme A binding pocket [chemical binding]; other site
349521002508	Immunoglobulin I-set domain; Region: I-set; pfam07679
349521002509	Immunoglobulin domain; Region: Ig_2; pfam13895
349521002510	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349521002511	Interdomain contacts; other site
349521002512	Cytokine receptor motif; other site
349521002513	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
349521002514	metal ion-dependent adhesion site (MIDAS); other site
349521002515	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
349521002516	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521002517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002518	active site
349521002519	phosphorylation site [posttranslational modification]
349521002520	intermolecular recognition site; other site
349521002521	dimerization interface [polypeptide binding]; other site
349521002522	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521002523	DNA binding site [nucleotide binding]
349521002524	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521002525	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521002526	dimer interface [polypeptide binding]; other site
349521002527	phosphorylation site [posttranslational modification]
349521002528	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521002529	ATP binding site [chemical binding]; other site
349521002530	Mg2+ binding site [ion binding]; other site
349521002531	G-X-G motif; other site
349521002532	major facilitator superfamily transporter; Provisional; Region: PRK05122
349521002533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521002534	putative substrate translocation pore; other site
349521002535	Protease prsW family; Region: PrsW-protease; pfam13367
349521002536	Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743
349521002537	dimer interface [polypeptide binding]; other site
349521002538	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
349521002539	maleylacetoacetate isomerase; Region: maiA; TIGR01262
349521002540	C-terminal domain interface [polypeptide binding]; other site
349521002541	GSH binding site (G-site) [chemical binding]; other site
349521002542	putative dimer interface [polypeptide binding]; other site
349521002543	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
349521002544	dimer interface [polypeptide binding]; other site
349521002545	N-terminal domain interface [polypeptide binding]; other site
349521002546	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
349521002547	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
349521002548	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
349521002549	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
349521002550	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
349521002551	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
349521002552	dimer interface [polypeptide binding]; other site
349521002553	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
349521002554	active site
349521002555	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
349521002556	cofactor binding site; other site
349521002557	metal binding site [ion binding]; metal-binding site
349521002558	Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171
349521002559	PLD-like domain; Region: PLDc_2; pfam13091
349521002560	putative active site [active]
349521002561	catalytic site [active]
349521002562	Protein of unknown function (DUF3012); Region: DUF3012; pfam11216
349521002563	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
349521002564	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521002565	N-terminal plug; other site
349521002566	ligand-binding site [chemical binding]; other site
349521002567	cobyric acid synthase; Provisional; Region: PRK00784
349521002568	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
349521002569	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
349521002570	catalytic triad [active]
349521002571	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
349521002572	homotrimer interface [polypeptide binding]; other site
349521002573	Walker A motif; other site
349521002574	GTP binding site [chemical binding]; other site
349521002575	Walker B motif; other site
349521002576	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
349521002577	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
349521002578	putative dimer interface [polypeptide binding]; other site
349521002579	active site pocket [active]
349521002580	putative cataytic base [active]
349521002581	cobalamin synthase; Reviewed; Region: cobS; PRK00235
349521002582	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349521002583	catalytic core [active]
349521002584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002585	Response regulator receiver domain; Region: Response_reg; pfam00072
349521002586	active site
349521002587	phosphorylation site [posttranslational modification]
349521002588	intermolecular recognition site; other site
349521002589	dimerization interface [polypeptide binding]; other site
349521002590	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521002591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521002592	dimer interface [polypeptide binding]; other site
349521002593	phosphorylation site [posttranslational modification]
349521002594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521002595	ATP binding site [chemical binding]; other site
349521002596	Mg2+ binding site [ion binding]; other site
349521002597	G-X-G motif; other site
349521002598	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521002599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002600	active site
349521002601	phosphorylation site [posttranslational modification]
349521002602	intermolecular recognition site; other site
349521002603	dimerization interface [polypeptide binding]; other site
349521002604	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
349521002605	Uncharacterized conserved protein [Function unknown]; Region: COG3287
349521002606	FIST N domain; Region: FIST; pfam08495
349521002607	FIST C domain; Region: FIST_C; pfam10442
349521002608	Inner membrane protein CreD; Region: CreD; pfam06123
349521002609	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
349521002610	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521002611	putative DNA binding site [nucleotide binding]; other site
349521002612	putative Zn2+ binding site [ion binding]; other site
349521002613	AsnC family; Region: AsnC_trans_reg; pfam01037
349521002614	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
349521002615	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
349521002616	hexamer interface [polypeptide binding]; other site
349521002617	ligand binding site [chemical binding]; other site
349521002618	putative active site [active]
349521002619	NAD(P) binding site [chemical binding]; other site
349521002620	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
349521002621	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
349521002622	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
349521002623	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
349521002624	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
349521002625	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
349521002626	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
349521002627	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
349521002628	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
349521002629	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
349521002630	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
349521002631	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
349521002632	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
349521002633	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
349521002634	Uncharacterized conserved protein [Function unknown]; Region: COG2308
349521002635	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
349521002636	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
349521002637	PspA/IM30 family; Region: PspA_IM30; pfam04012
349521002638	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
349521002639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
349521002640	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
349521002641	ATPase involved in DNA repair; Region: DUF3686; pfam12458
349521002642	AAA domain; Region: AAA_22; pfam13401
349521002643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349521002644	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
349521002645	putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799
349521002646	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521002647	catalytic residue [active]
349521002648	Protein of unknown function (DUF503); Region: DUF503; pfam04456
349521002649	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521002650	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
349521002651	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521002652	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521002653	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
349521002654	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521002655	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521002656	metal binding site [ion binding]; metal-binding site
349521002657	active site
349521002658	I-site; other site
349521002659	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521002660	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
349521002661	Uncharacterized conserved protein [Function unknown]; Region: COG0398
349521002662	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
349521002663	mercuric reductase; Validated; Region: PRK06370
349521002664	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349521002665	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521002666	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349521002667	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
349521002668	dimer interface [polypeptide binding]; other site
349521002669	allosteric magnesium binding site [ion binding]; other site
349521002670	active site
349521002671	aspartate-rich active site metal binding site; other site
349521002672	Schiff base residues; other site
349521002673	polyphosphate kinase; Provisional; Region: PRK05443
349521002674	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
349521002675	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
349521002676	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
349521002677	putative domain interface [polypeptide binding]; other site
349521002678	putative active site [active]
349521002679	catalytic site [active]
349521002680	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
349521002681	putative domain interface [polypeptide binding]; other site
349521002682	putative active site [active]
349521002683	catalytic site [active]
349521002684	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
349521002685	Domain of unknown function DUF20; Region: UPF0118; pfam01594
349521002686	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
349521002687	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
349521002688	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
349521002689	active site
349521002690	(T/H)XGH motif; other site
349521002691	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
349521002692	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
349521002693	NAD(P) binding site [chemical binding]; other site
349521002694	catalytic residues [active]
349521002695	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521002696	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521002697	Bacterial transcriptional repressor; Region: TetR; pfam13972
349521002698	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
349521002699	G1 box; other site
349521002700	GTP/Mg2+ binding site [chemical binding]; other site
349521002701	Switch I region; other site
349521002702	G2 box; other site
349521002703	G3 box; other site
349521002704	Switch II region; other site
349521002705	G4 box; other site
349521002706	G5 box; other site
349521002707	Cytochrome c553 [Energy production and conversion]; Region: COG2863
349521002708	Cytochrome c; Region: Cytochrom_C; cl11414
349521002709	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
349521002710	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
349521002711	catalytic residues [active]
349521002712	hinge region; other site
349521002713	alpha helical domain; other site
349521002714	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
349521002715	putative catalytic site [active]
349521002716	putative metal binding site [ion binding]; other site
349521002717	putative phosphate binding site [ion binding]; other site
349521002718	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
349521002719	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
349521002720	hypothetical protein; Reviewed; Region: PRK00024
349521002721	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
349521002722	MPN+ (JAMM) motif; other site
349521002723	Zinc-binding site [ion binding]; other site
349521002724	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
349521002725	Flavoprotein; Region: Flavoprotein; pfam02441
349521002726	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
349521002727	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
349521002728	trimer interface [polypeptide binding]; other site
349521002729	active site
349521002730	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
349521002731	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
349521002732	active site
349521002733	substrate binding site [chemical binding]; other site
349521002734	metal binding site [ion binding]; metal-binding site
349521002735	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
349521002736	feedback inhibition sensing region; other site
349521002737	homohexameric interface [polypeptide binding]; other site
349521002738	carbamate kinase; Reviewed; Region: PRK12686
349521002739	nucleotide binding site [chemical binding]; other site
349521002740	N-acetyl-L-glutamate binding site [chemical binding]; other site
349521002741	acetylornithine deacetylase; Provisional; Region: PRK05111
349521002742	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
349521002743	metal binding site [ion binding]; metal-binding site
349521002744	putative dimer interface [polypeptide binding]; other site
349521002745	N-acetylglutamate synthase; Validated; Region: PRK05279
349521002746	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
349521002747	putative feedback inhibition sensing region; other site
349521002748	putative nucleotide binding site [chemical binding]; other site
349521002749	putative substrate binding site [chemical binding]; other site
349521002750	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521002751	Coenzyme A binding pocket [chemical binding]; other site
349521002752	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
349521002753	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
349521002754	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521002755	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521002756	metal binding site [ion binding]; metal-binding site
349521002757	active site
349521002758	I-site; other site
349521002759	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521002760	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
349521002761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521002762	active site
349521002763	phosphorylation site [posttranslational modification]
349521002764	intermolecular recognition site; other site
349521002765	dimerization interface [polypeptide binding]; other site
349521002766	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521002767	Walker A motif; other site
349521002768	ATP binding site [chemical binding]; other site
349521002769	Walker B motif; other site
349521002770	arginine finger; other site
349521002771	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521002772	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
349521002773	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349521002774	putative active site [active]
349521002775	heme pocket [chemical binding]; other site
349521002776	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521002777	dimer interface [polypeptide binding]; other site
349521002778	phosphorylation site [posttranslational modification]
349521002779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521002780	ATP binding site [chemical binding]; other site
349521002781	Mg2+ binding site [ion binding]; other site
349521002782	G-X-G motif; other site
349521002783	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521002784	glutamine synthetase; Provisional; Region: glnA; PRK09469
349521002785	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
349521002786	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
349521002787	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
349521002788	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
349521002789	G1 box; other site
349521002790	putative GEF interaction site [polypeptide binding]; other site
349521002791	GTP/Mg2+ binding site [chemical binding]; other site
349521002792	Switch I region; other site
349521002793	G2 box; other site
349521002794	G3 box; other site
349521002795	Switch II region; other site
349521002796	G4 box; other site
349521002797	G5 box; other site
349521002798	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
349521002799	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
349521002800	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
349521002801	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
349521002802	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
349521002803	putative active site [active]
349521002804	dimerization interface [polypeptide binding]; other site
349521002805	putative tRNAtyr binding site [nucleotide binding]; other site
349521002806	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
349521002807	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
349521002808	eyelet of channel; other site
349521002809	trimer interface [polypeptide binding]; other site
349521002810	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
349521002811	putative active site [active]
349521002812	putative metal binding residues [ion binding]; other site
349521002813	signature motif; other site
349521002814	putative triphosphate binding site [ion binding]; other site
349521002815	Protein of unknown function, DUF547; Region: DUF547; pfam04784
349521002816	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
349521002817	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349521002818	metal binding triad; other site
349521002819	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
349521002820	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349521002821	metal binding triad; other site
349521002822	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
349521002823	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
349521002824	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
349521002825	homodimer interface [polypeptide binding]; other site
349521002826	substrate-cofactor binding pocket; other site
349521002827	catalytic residue [active]
349521002828	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
349521002829	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
349521002830	putative active site [active]
349521002831	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
349521002832	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
349521002833	putative active site [active]
349521002834	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349521002835	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
349521002836	putative metal binding site; other site
349521002837	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521002838	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
349521002839	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521002840	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
349521002841	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
349521002842	O-Antigen ligase; Region: Wzy_C; pfam04932
349521002843	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
349521002844	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
349521002845	active site
349521002846	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349521002847	active site
349521002848	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521002849	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
349521002850	putative ADP-binding pocket [chemical binding]; other site
349521002851	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
349521002852	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
349521002853	putative active site [active]
349521002854	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521002855	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521002856	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
349521002857	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
349521002858	putative acyl-acceptor binding pocket; other site
349521002859	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
349521002860	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
349521002861	putative ribose interaction site [chemical binding]; other site
349521002862	putative ADP binding site [chemical binding]; other site
349521002863	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
349521002864	active site
349521002865	HIGH motif; other site
349521002866	nucleotide binding site [chemical binding]; other site
349521002867	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
349521002868	dimer interface [polypeptide binding]; other site
349521002869	substrate binding site [chemical binding]; other site
349521002870	metal binding sites [ion binding]; metal-binding site
349521002871	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349521002872	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521002873	active site
349521002874	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
349521002875	tetramer (dimer of dimers) interface [polypeptide binding]; other site
349521002876	active site
349521002877	dimer interface [polypeptide binding]; other site
349521002878	threonine dehydratase; Reviewed; Region: PRK09224
349521002879	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
349521002880	tetramer interface [polypeptide binding]; other site
349521002881	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521002882	catalytic residue [active]
349521002883	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
349521002884	putative Ile/Val binding site [chemical binding]; other site
349521002885	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
349521002886	putative Ile/Val binding site [chemical binding]; other site
349521002887	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
349521002888	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
349521002889	Cell division protein ZapA; Region: ZapA; pfam05164
349521002890	TIGR02449 family protein; Region: TIGR02449
349521002891	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
349521002892	proline aminopeptidase P II; Provisional; Region: PRK10879
349521002893	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
349521002894	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
349521002895	active site
349521002896	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
349521002897	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
349521002898	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
349521002899	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
349521002900	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
349521002901	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
349521002902	sec-independent translocase; Provisional; Region: tatB; PRK00404
349521002903	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
349521002904	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
349521002905	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
349521002906	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
349521002907	metal binding site [ion binding]; metal-binding site
349521002908	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
349521002909	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
349521002910	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
349521002911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
349521002912	SCP-2 sterol transfer family; Region: SCP2; pfam02036
349521002913	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
349521002914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521002915	S-adenosylmethionine binding site [chemical binding]; other site
349521002916	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650
349521002917	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521002918	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
349521002919	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
349521002920	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
349521002921	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521002922	active site
349521002923	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521002924	active site
349521002925	Predicted membrane protein [Function unknown]; Region: COG3748
349521002926	Protein of unknown function (DUF989); Region: DUF989; pfam06181
349521002927	Cytochrome c; Region: Cytochrom_C; pfam00034
349521002928	guanine deaminase; Provisional; Region: PRK09228
349521002929	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
349521002930	active site
349521002931	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
349521002932	ureidoglycolate hydrolase; Provisional; Region: PRK03606
349521002933	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
349521002934	active site
349521002935	homotetramer interface [polypeptide binding]; other site
349521002936	putative OHCU decarboxylase; Provisional; Region: PRK13798
349521002937	allantoicase; Provisional; Region: PRK13257
349521002938	Allantoicase repeat; Region: Allantoicase; pfam03561
349521002939	Allantoicase repeat; Region: Allantoicase; pfam03561
349521002940	allantoinase; Region: allantoinase; TIGR03178
349521002941	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
349521002942	active site
349521002943	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
349521002944	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
349521002945	XdhC Rossmann domain; Region: XdhC_C; pfam13478
349521002946	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
349521002947	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349521002948	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349521002949	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
349521002950	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349521002951	catalytic loop [active]
349521002952	iron binding site [ion binding]; other site
349521002953	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
349521002954	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
349521002955	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
349521002956	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349521002957	Walker A/P-loop; other site
349521002958	ATP binding site [chemical binding]; other site
349521002959	Q-loop/lid; other site
349521002960	ABC transporter signature motif; other site
349521002961	Walker B; other site
349521002962	D-loop; other site
349521002963	H-loop/switch region; other site
349521002964	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349521002965	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349521002966	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
349521002967	TM-ABC transporter signature motif; other site
349521002968	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349521002969	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
349521002970	TM-ABC transporter signature motif; other site
349521002971	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
349521002972	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
349521002973	putative ligand binding site [chemical binding]; other site
349521002974	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
349521002975	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
349521002976	active site
349521002977	putative substrate binding pocket [chemical binding]; other site
349521002978	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
349521002979	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521002980	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
349521002981	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
349521002982	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
349521002983	dimerization interface [polypeptide binding]; other site
349521002984	substrate binding site [chemical binding]; other site
349521002985	active site
349521002986	calcium binding site [ion binding]; other site
349521002987	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
349521002988	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349521002989	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349521002990	protein binding site [polypeptide binding]; other site
349521002991	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349521002992	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
349521002993	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
349521002994	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
349521002995	active site
349521002996	HIGH motif; other site
349521002997	KMSK motif region; other site
349521002998	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
349521002999	tRNA binding surface [nucleotide binding]; other site
349521003000	anticodon binding site; other site
349521003001	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
349521003002	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
349521003003	DNA binding residues [nucleotide binding]
349521003004	putative dimer interface [polypeptide binding]; other site
349521003005	putative metal binding residues [ion binding]; other site
349521003006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521003007	Domain of unknown function (DUF386); Region: DUF386; cl01047
349521003008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521003009	S-adenosylmethionine binding site [chemical binding]; other site
349521003010	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
349521003011	dimer interface [polypeptide binding]; other site
349521003012	motif 1; other site
349521003013	active site
349521003014	motif 2; other site
349521003015	motif 3; other site
349521003016	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521003017	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521003018	ligand binding site [chemical binding]; other site
349521003019	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
349521003020	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521003021	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521003022	substrate binding pocket [chemical binding]; other site
349521003023	membrane-bound complex binding site; other site
349521003024	hinge residues; other site
349521003025	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
349521003026	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
349521003027	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
349521003028	peptide binding site [polypeptide binding]; other site
349521003029	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
349521003030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521003031	dimer interface [polypeptide binding]; other site
349521003032	conserved gate region; other site
349521003033	putative PBP binding loops; other site
349521003034	ABC-ATPase subunit interface; other site
349521003035	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
349521003036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521003037	dimer interface [polypeptide binding]; other site
349521003038	conserved gate region; other site
349521003039	putative PBP binding loops; other site
349521003040	ABC-ATPase subunit interface; other site
349521003041	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
349521003042	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521003043	Walker A/P-loop; other site
349521003044	ATP binding site [chemical binding]; other site
349521003045	Q-loop/lid; other site
349521003046	ABC transporter signature motif; other site
349521003047	Walker B; other site
349521003048	D-loop; other site
349521003049	H-loop/switch region; other site
349521003050	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349521003051	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
349521003052	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521003053	Walker A/P-loop; other site
349521003054	ATP binding site [chemical binding]; other site
349521003055	Q-loop/lid; other site
349521003056	ABC transporter signature motif; other site
349521003057	Walker B; other site
349521003058	D-loop; other site
349521003059	H-loop/switch region; other site
349521003060	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349521003061	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349521003062	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521003063	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521003064	Nitrate and nitrite sensing; Region: NIT; pfam08376
349521003065	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521003066	dimerization interface [polypeptide binding]; other site
349521003067	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521003068	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521003069	dimer interface [polypeptide binding]; other site
349521003070	putative CheW interface [polypeptide binding]; other site
349521003071	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
349521003072	aromatic chitin/cellulose binding site residues [chemical binding]; other site
349521003073	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
349521003074	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
349521003075	putative sugar binding site [chemical binding]; other site
349521003076	catalytic residues [active]
349521003077	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
349521003078	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
349521003079	aromatic chitin/cellulose binding site residues [chemical binding]; other site
349521003080	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
349521003081	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
349521003082	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
349521003083	active site
349521003084	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
349521003085	Chitinase C; Region: ChiC; pfam06483
349521003086	Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204
349521003087	aromatic chitin/cellulose binding site residues [chemical binding]; other site
349521003088	ligand binding site [chemical binding]; other site
349521003089	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521003090	non-specific DNA binding site [nucleotide binding]; other site
349521003091	salt bridge; other site
349521003092	sequence-specific DNA binding site [nucleotide binding]; other site
349521003093	HipA N-terminal domain; Region: Couple_hipA; cl11853
349521003094	HipA-like N-terminal domain; Region: HipA_N; pfam07805
349521003095	HipA-like C-terminal domain; Region: HipA_C; pfam07804
349521003096	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521003097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521003098	active site
349521003099	phosphorylation site [posttranslational modification]
349521003100	intermolecular recognition site; other site
349521003101	dimerization interface [polypeptide binding]; other site
349521003102	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521003103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521003104	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521003105	putative effector binding pocket; other site
349521003106	dimerization interface [polypeptide binding]; other site
349521003107	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
349521003108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521003109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521003110	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
349521003111	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521003112	hypothetical protein; Provisional; Region: PRK11171
349521003113	Cupin domain; Region: Cupin_2; pfam07883
349521003114	Cupin domain; Region: Cupin_2; cl17218
349521003115	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
349521003116	Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957
349521003117	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
349521003118	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
349521003119	tetrameric interface [polypeptide binding]; other site
349521003120	NAD binding site [chemical binding]; other site
349521003121	catalytic residues [active]
349521003122	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
349521003123	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
349521003124	Metal-binding active site; metal-binding site
349521003125	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
349521003126	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349521003127	PYR/PP interface [polypeptide binding]; other site
349521003128	dimer interface [polypeptide binding]; other site
349521003129	TPP binding site [chemical binding]; other site
349521003130	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349521003131	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
349521003132	TPP-binding site; other site
349521003133	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349521003134	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
349521003135	substrate binding site [chemical binding]; other site
349521003136	ATP binding site [chemical binding]; other site
349521003137	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
349521003138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
349521003139	Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130
349521003140	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
349521003141	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349521003142	putative ligand binding site [chemical binding]; other site
349521003143	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349521003144	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349521003145	Walker A/P-loop; other site
349521003146	ATP binding site [chemical binding]; other site
349521003147	Q-loop/lid; other site
349521003148	ABC transporter signature motif; other site
349521003149	Walker B; other site
349521003150	D-loop; other site
349521003151	H-loop/switch region; other site
349521003152	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349521003153	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349521003154	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349521003155	TM-ABC transporter signature motif; other site
349521003156	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
349521003157	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349521003158	DNA binding site [nucleotide binding]
349521003159	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
349521003160	putative ligand binding site [chemical binding]; other site
349521003161	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
349521003162	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521003163	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
349521003164	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
349521003165	THF binding site; other site
349521003166	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
349521003167	substrate binding site [chemical binding]; other site
349521003168	THF binding site; other site
349521003169	zinc-binding site [ion binding]; other site
349521003170	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
349521003171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521003172	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
349521003173	putative dimerization interface [polypeptide binding]; other site
349521003174	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
349521003175	MarR family; Region: MarR_2; pfam12802
349521003176	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
349521003177	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
349521003178	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521003179	Walker A motif; other site
349521003180	ATP binding site [chemical binding]; other site
349521003181	Walker B motif; other site
349521003182	arginine finger; other site
349521003183	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521003184	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
349521003185	DNA binding residues [nucleotide binding]
349521003186	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349521003187	Integrase core domain; Region: rve; pfam00665
349521003188	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349521003189	Homeodomain-like domain; Region: HTH_23; pfam13384
349521003190	Winged helix-turn helix; Region: HTH_29; pfam13551
349521003191	Homeodomain-like domain; Region: HTH_32; pfam13565
349521003192	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521003193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349521003194	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
349521003195	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
349521003196	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
349521003197	catalytic residues [active]
349521003198	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
349521003199	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
349521003200	FMN binding site [chemical binding]; other site
349521003201	active site
349521003202	substrate binding site [chemical binding]; other site
349521003203	catalytic residue [active]
349521003204	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
349521003205	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521003206	dimer interface [polypeptide binding]; other site
349521003207	putative metal binding site [ion binding]; other site
349521003208	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521003209	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521003210	putative effector binding pocket; other site
349521003211	dimerization interface [polypeptide binding]; other site
349521003212	PhoD-like phosphatase; Region: PhoD; pfam09423
349521003213	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
349521003214	putative active site [active]
349521003215	putative metal binding site [ion binding]; other site
349521003216	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349521003217	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521003218	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521003219	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521003220	putative effector binding pocket; other site
349521003221	dimerization interface [polypeptide binding]; other site
349521003222	Pirin-related protein [General function prediction only]; Region: COG1741
349521003223	Pirin; Region: Pirin; pfam02678
349521003224	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
349521003225	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521003226	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521003227	substrate binding pocket [chemical binding]; other site
349521003228	membrane-bound complex binding site; other site
349521003229	hinge residues; other site
349521003230	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521003231	RHS Repeat; Region: RHS_repeat; pfam05593
349521003232	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521003233	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
349521003234	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521003235	RHS Repeat; Region: RHS_repeat; pfam05593
349521003236	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521003237	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521003238	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521003239	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
349521003240	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
349521003241	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521003242	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521003243	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521003244	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521003245	substrate binding pocket [chemical binding]; other site
349521003246	membrane-bound complex binding site; other site
349521003247	hinge residues; other site
349521003248	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521003249	macrolide transporter subunit MacA; Provisional; Region: PRK11578
349521003250	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521003251	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
349521003252	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521003253	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
349521003254	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349521003255	Walker A/P-loop; other site
349521003256	ATP binding site [chemical binding]; other site
349521003257	Q-loop/lid; other site
349521003258	ABC transporter signature motif; other site
349521003259	Walker B; other site
349521003260	D-loop; other site
349521003261	H-loop/switch region; other site
349521003262	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349521003263	FtsX-like permease family; Region: FtsX; pfam02687
349521003264	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
349521003265	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
349521003266	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
349521003267	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
349521003268	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
349521003269	SmpB-tmRNA interface; other site
349521003270	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
349521003271	Na2 binding site [ion binding]; other site
349521003272	putative substrate binding site 1 [chemical binding]; other site
349521003273	Na binding site 1 [ion binding]; other site
349521003274	putative substrate binding site 2 [chemical binding]; other site
349521003275	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
349521003276	putative coenzyme Q binding site [chemical binding]; other site
349521003277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
349521003278	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
349521003279	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
349521003280	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
349521003281	metal binding site 2 [ion binding]; metal-binding site
349521003282	putative DNA binding helix; other site
349521003283	metal binding site 1 [ion binding]; metal-binding site
349521003284	dimer interface [polypeptide binding]; other site
349521003285	structural Zn2+ binding site [ion binding]; other site
349521003286	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
349521003287	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
349521003288	Walker A/P-loop; other site
349521003289	ATP binding site [chemical binding]; other site
349521003290	Q-loop/lid; other site
349521003291	Flagellar protein FliS; Region: FliS; cl00654
349521003292	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
349521003293	ABC transporter signature motif; other site
349521003294	Walker B; other site
349521003295	D-loop; other site
349521003296	H-loop/switch region; other site
349521003297	GrpE; Region: GrpE; pfam01025
349521003298	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
349521003299	dimer interface [polypeptide binding]; other site
349521003300	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
349521003301	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
349521003302	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
349521003303	nucleotide binding site [chemical binding]; other site
349521003304	chaperone protein DnaJ; Provisional; Region: PRK10767
349521003305	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349521003306	HSP70 interaction site [polypeptide binding]; other site
349521003307	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
349521003308	substrate binding site [polypeptide binding]; other site
349521003309	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
349521003310	Zn binding sites [ion binding]; other site
349521003311	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
349521003312	dimer interface [polypeptide binding]; other site
349521003313	dihydrodipicolinate reductase; Provisional; Region: PRK00048
349521003314	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
349521003315	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
349521003316	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
349521003317	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
349521003318	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
349521003319	catalytic site [active]
349521003320	subunit interface [polypeptide binding]; other site
349521003321	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
349521003322	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349521003323	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
349521003324	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
349521003325	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349521003326	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349521003327	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
349521003328	IMP binding site; other site
349521003329	dimer interface [polypeptide binding]; other site
349521003330	interdomain contacts; other site
349521003331	partial ornithine binding site; other site
349521003332	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
349521003333	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
349521003334	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
349521003335	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
349521003336	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
349521003337	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521003338	S-adenosylmethionine binding site [chemical binding]; other site
349521003339	FtsH Extracellular; Region: FtsH_ext; pfam06480
349521003340	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
349521003341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521003342	Walker A motif; other site
349521003343	ATP binding site [chemical binding]; other site
349521003344	Walker B motif; other site
349521003345	arginine finger; other site
349521003346	Peptidase family M41; Region: Peptidase_M41; pfam01434
349521003347	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
349521003348	dihydropteroate synthase; Region: DHPS; TIGR01496
349521003349	substrate binding pocket [chemical binding]; other site
349521003350	dimer interface [polypeptide binding]; other site
349521003351	inhibitor binding site; inhibition site
349521003352	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
349521003353	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
349521003354	active site
349521003355	substrate binding site [chemical binding]; other site
349521003356	metal binding site [ion binding]; metal-binding site
349521003357	triosephosphate isomerase; Provisional; Region: PRK14567
349521003358	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
349521003359	substrate binding site [chemical binding]; other site
349521003360	dimer interface [polypeptide binding]; other site
349521003361	catalytic triad [active]
349521003362	Preprotein translocase SecG subunit; Region: SecG; pfam03840
349521003363	ribosome maturation protein RimP; Reviewed; Region: PRK00092
349521003364	Sm and related proteins; Region: Sm_like; cl00259
349521003365	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
349521003366	putative oligomer interface [polypeptide binding]; other site
349521003367	putative RNA binding site [nucleotide binding]; other site
349521003368	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
349521003369	NusA N-terminal domain; Region: NusA_N; pfam08529
349521003370	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
349521003371	RNA binding site [nucleotide binding]; other site
349521003372	homodimer interface [polypeptide binding]; other site
349521003373	NusA-like KH domain; Region: KH_5; pfam13184
349521003374	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
349521003375	G-X-X-G motif; other site
349521003376	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
349521003377	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
349521003378	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
349521003379	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
349521003380	translation initiation factor IF-2; Validated; Region: infB; PRK05306
349521003381	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
349521003382	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
349521003383	G1 box; other site
349521003384	putative GEF interaction site [polypeptide binding]; other site
349521003385	GTP/Mg2+ binding site [chemical binding]; other site
349521003386	Switch I region; other site
349521003387	G2 box; other site
349521003388	G3 box; other site
349521003389	Switch II region; other site
349521003390	G4 box; other site
349521003391	G5 box; other site
349521003392	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
349521003393	Translation-initiation factor 2; Region: IF-2; pfam11987
349521003394	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
349521003395	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
349521003396	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
349521003397	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
349521003398	RNA binding site [nucleotide binding]; other site
349521003399	active site
349521003400	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
349521003401	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
349521003402	16S/18S rRNA binding site [nucleotide binding]; other site
349521003403	S13e-L30e interaction site [polypeptide binding]; other site
349521003404	25S rRNA binding site [nucleotide binding]; other site
349521003405	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
349521003406	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
349521003407	RNase E interface [polypeptide binding]; other site
349521003408	trimer interface [polypeptide binding]; other site
349521003409	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
349521003410	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
349521003411	RNase E interface [polypeptide binding]; other site
349521003412	trimer interface [polypeptide binding]; other site
349521003413	active site
349521003414	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
349521003415	putative nucleic acid binding region [nucleotide binding]; other site
349521003416	G-X-X-G motif; other site
349521003417	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
349521003418	RNA binding site [nucleotide binding]; other site
349521003419	domain interface; other site
349521003420	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349521003421	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
349521003422	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349521003423	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
349521003424	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
349521003425	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
349521003426	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349521003427	Walker A/P-loop; other site
349521003428	ATP binding site [chemical binding]; other site
349521003429	Q-loop/lid; other site
349521003430	ABC transporter signature motif; other site
349521003431	Walker B; other site
349521003432	D-loop; other site
349521003433	H-loop/switch region; other site
349521003434	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
349521003435	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349521003436	Walker A/P-loop; other site
349521003437	ATP binding site [chemical binding]; other site
349521003438	Q-loop/lid; other site
349521003439	ABC transporter signature motif; other site
349521003440	Walker B; other site
349521003441	D-loop; other site
349521003442	H-loop/switch region; other site
349521003443	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
349521003444	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
349521003445	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349521003446	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349521003447	TM-ABC transporter signature motif; other site
349521003448	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349521003449	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349521003450	TM-ABC transporter signature motif; other site
349521003451	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
349521003452	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
349521003453	dimerization interface [polypeptide binding]; other site
349521003454	ligand binding site [chemical binding]; other site
349521003455	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
349521003456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521003457	Walker A motif; other site
349521003458	ATP binding site [chemical binding]; other site
349521003459	Walker B motif; other site
349521003460	arginine finger; other site
349521003461	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
349521003462	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
349521003463	putative deacylase active site [active]
349521003464	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
349521003465	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
349521003466	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521003467	binding surface
349521003468	TPR motif; other site
349521003469	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
349521003470	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521003471	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
349521003472	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349521003473	FtsX-like permease family; Region: FtsX; pfam02687
349521003474	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349521003475	FtsX-like permease family; Region: FtsX; pfam02687
349521003476	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349521003477	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349521003478	Walker A/P-loop; other site
349521003479	ATP binding site [chemical binding]; other site
349521003480	Q-loop/lid; other site
349521003481	ABC transporter signature motif; other site
349521003482	Walker B; other site
349521003483	D-loop; other site
349521003484	H-loop/switch region; other site
349521003485	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521003486	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521003487	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521003488	PilZ domain; Region: PilZ; pfam07238
349521003489	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
349521003490	FAD binding domain; Region: FAD_binding_4; pfam01565
349521003491	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349521003492	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
349521003493	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
349521003494	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
349521003495	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
349521003496	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
349521003497	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
349521003498	Cysteine-rich domain; Region: CCG; pfam02754
349521003499	Cysteine-rich domain; Region: CCG; pfam02754
349521003500	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
349521003501	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521003502	DNA-binding site [nucleotide binding]; DNA binding site
349521003503	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
349521003504	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
349521003505	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
349521003506	dimer interface [polypeptide binding]; other site
349521003507	TPP-binding site [chemical binding]; other site
349521003508	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
349521003509	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
349521003510	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349521003511	E3 interaction surface; other site
349521003512	lipoyl attachment site [posttranslational modification]; other site
349521003513	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349521003514	E3 interaction surface; other site
349521003515	lipoyl attachment site [posttranslational modification]; other site
349521003516	e3 binding domain; Region: E3_binding; pfam02817
349521003517	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
349521003518	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
349521003519	Sel1-like repeats; Region: SEL1; smart00671
349521003520	Sel1-like repeats; Region: SEL1; smart00671
349521003521	Sel1 repeat; Region: Sel1; cl02723
349521003522	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521003523	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521003524	EamA-like transporter family; Region: EamA; pfam00892
349521003525	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521003526	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521003527	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521003528	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
349521003529	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
349521003530	NADP binding site [chemical binding]; other site
349521003531	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521003532	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521003533	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521003534	putative effector binding pocket; other site
349521003535	dimerization interface [polypeptide binding]; other site
349521003536	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521003537	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
349521003538	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
349521003539	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
349521003540	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
349521003541	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
349521003542	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521003543	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521003544	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
349521003545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521003546	dimer interface [polypeptide binding]; other site
349521003547	conserved gate region; other site
349521003548	putative PBP binding loops; other site
349521003549	ABC-ATPase subunit interface; other site
349521003550	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349521003551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521003552	dimer interface [polypeptide binding]; other site
349521003553	conserved gate region; other site
349521003554	putative PBP binding loops; other site
349521003555	ABC-ATPase subunit interface; other site
349521003556	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
349521003557	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349521003558	Walker A/P-loop; other site
349521003559	ATP binding site [chemical binding]; other site
349521003560	Q-loop/lid; other site
349521003561	ABC transporter signature motif; other site
349521003562	Walker B; other site
349521003563	D-loop; other site
349521003564	H-loop/switch region; other site
349521003565	TOBE domain; Region: TOBE_2; pfam08402
349521003566	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
349521003567	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
349521003568	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
349521003569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521003570	sorbitol dehydrogenase; Provisional; Region: PRK07067
349521003571	NAD(P) binding site [chemical binding]; other site
349521003572	active site
349521003573	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
349521003574	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
349521003575	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521003576	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521003577	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
349521003578	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
349521003579	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349521003580	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521003581	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521003582	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521003583	putative effector binding pocket; other site
349521003584	dimerization interface [polypeptide binding]; other site
349521003585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521003586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521003587	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521003588	dimerization interface [polypeptide binding]; other site
349521003589	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
349521003590	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
349521003591	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
349521003592	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
349521003593	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
349521003594	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521003595	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521003596	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521003597	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
349521003598	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521003599	N-terminal plug; other site
349521003600	ligand-binding site [chemical binding]; other site
349521003601	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
349521003602	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
349521003603	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349521003604	catalytic residues [active]
349521003605	PAS domain S-box; Region: sensory_box; TIGR00229
349521003606	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521003607	putative active site [active]
349521003608	heme pocket [chemical binding]; other site
349521003609	PAS domain S-box; Region: sensory_box; TIGR00229
349521003610	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521003611	putative active site [active]
349521003612	heme pocket [chemical binding]; other site
349521003613	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521003614	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521003615	dimer interface [polypeptide binding]; other site
349521003616	putative CheW interface [polypeptide binding]; other site
349521003617	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
349521003618	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521003619	dimerization interface [polypeptide binding]; other site
349521003620	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521003621	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521003622	metal binding site [ion binding]; metal-binding site
349521003623	active site
349521003624	I-site; other site
349521003625	Domain of unknown function (DUF3885); Region: DUF3885; pfam13021
349521003626	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521003627	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
349521003628	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349521003629	active site
349521003630	metal binding site [ion binding]; metal-binding site
349521003631	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
349521003632	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521003633	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
349521003634	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521003635	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
349521003636	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
349521003637	DNA binding residues [nucleotide binding]
349521003638	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
349521003639	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349521003640	S-adenosylmethionine binding site [chemical binding]; other site
349521003641	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521003642	salt bridge; other site
349521003643	non-specific DNA binding site [nucleotide binding]; other site
349521003644	sequence-specific DNA binding site [nucleotide binding]; other site
349521003645	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
349521003646	Homeodomain-like domain; Region: HTH_23; pfam13384
349521003647	Winged helix-turn helix; Region: HTH_29; pfam13551
349521003648	Homeodomain-like domain; Region: HTH_32; pfam13565
349521003649	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521003650	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349521003651	oxidative damage protection protein; Provisional; Region: PRK05408
349521003652	adenine DNA glycosylase; Provisional; Region: PRK10880
349521003653	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349521003654	minor groove reading motif; other site
349521003655	helix-hairpin-helix signature motif; other site
349521003656	substrate binding pocket [chemical binding]; other site
349521003657	active site
349521003658	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
349521003659	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
349521003660	DNA binding and oxoG recognition site [nucleotide binding]
349521003661	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
349521003662	putative hydrophobic ligand binding site [chemical binding]; other site
349521003663	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
349521003664	putative active site pocket [active]
349521003665	4-fold oligomerization interface [polypeptide binding]; other site
349521003666	metal binding residues [ion binding]; metal-binding site
349521003667	3-fold/trimer interface [polypeptide binding]; other site
349521003668	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
349521003669	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
349521003670	putative active site [active]
349521003671	oxyanion strand; other site
349521003672	catalytic triad [active]
349521003673	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
349521003674	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
349521003675	catalytic residues [active]
349521003676	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
349521003677	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
349521003678	substrate binding site [chemical binding]; other site
349521003679	glutamase interaction surface [polypeptide binding]; other site
349521003680	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
349521003681	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
349521003682	NodB motif; other site
349521003683	putative active site [active]
349521003684	putative catalytic site [active]
349521003685	Zn binding site [ion binding]; other site
349521003686	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
349521003687	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
349521003688	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
349521003689	protein binding site [polypeptide binding]; other site
349521003690	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
349521003691	Catalytic dyad [active]
349521003692	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
349521003693	Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; pfam05405
349521003694	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521003695	phosphoglyceromutase; Provisional; Region: PRK05434
349521003696	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
349521003697	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349521003698	active site residue [active]
349521003699	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
349521003700	GSH binding site [chemical binding]; other site
349521003701	catalytic residues [active]
349521003702	preprotein translocase subunit SecB; Validated; Region: PRK05751
349521003703	SecA binding site; other site
349521003704	Preprotein binding site; other site
349521003705	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
349521003706	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
349521003707	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
349521003708	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
349521003709	Walker A/P-loop; other site
349521003710	ATP binding site [chemical binding]; other site
349521003711	Q-loop/lid; other site
349521003712	ABC transporter signature motif; other site
349521003713	Walker B; other site
349521003714	D-loop; other site
349521003715	H-loop/switch region; other site
349521003716	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
349521003717	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
349521003718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521003719	dimer interface [polypeptide binding]; other site
349521003720	conserved gate region; other site
349521003721	putative PBP binding loops; other site
349521003722	ABC-ATPase subunit interface; other site
349521003723	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
349521003724	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
349521003725	putative acyltransferase; Provisional; Region: PRK05790
349521003726	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349521003727	dimer interface [polypeptide binding]; other site
349521003728	active site
349521003729	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
349521003730	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
349521003731	active site
349521003732	NTP binding site [chemical binding]; other site
349521003733	metal binding triad [ion binding]; metal-binding site
349521003734	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
349521003735	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521003736	Zn2+ binding site [ion binding]; other site
349521003737	Mg2+ binding site [ion binding]; other site
349521003738	LPP20 lipoprotein; Region: LPP20; pfam02169
349521003739	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
349521003740	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
349521003741	heme-binding site [chemical binding]; other site
349521003742	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
349521003743	FAD binding pocket [chemical binding]; other site
349521003744	FAD binding motif [chemical binding]; other site
349521003745	phosphate binding motif [ion binding]; other site
349521003746	beta-alpha-beta structure motif; other site
349521003747	NAD binding pocket [chemical binding]; other site
349521003748	Heme binding  pocket [chemical binding]; other site
349521003749	NnrS protein; Region: NnrS; pfam05940
349521003750	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
349521003751	GAF domain; Region: GAF; pfam01590
349521003752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521003753	Walker A motif; other site
349521003754	ATP binding site [chemical binding]; other site
349521003755	Walker B motif; other site
349521003756	arginine finger; other site
349521003757	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521003758	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521003759	substrate binding pocket [chemical binding]; other site
349521003760	membrane-bound complex binding site; other site
349521003761	hinge residues; other site
349521003762	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
349521003763	RHS protein; Region: RHS; pfam03527
349521003764	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521003765	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521003766	RHS Repeat; Region: RHS_repeat; pfam05593
349521003767	RHS Repeat; Region: RHS_repeat; pfam05593
349521003768	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
349521003769	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
349521003770	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
349521003771	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
349521003772	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
349521003773	putative deacylase active site [active]
349521003774	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
349521003775	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
349521003776	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521003777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521003778	ATP binding site [chemical binding]; other site
349521003779	Mg2+ binding site [ion binding]; other site
349521003780	G-X-G motif; other site
349521003781	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
349521003782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521003783	active site
349521003784	phosphorylation site [posttranslational modification]
349521003785	intermolecular recognition site; other site
349521003786	dimerization interface [polypeptide binding]; other site
349521003787	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521003788	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
349521003789	putative kinase; Provisional; Region: PRK09954
349521003790	HTH domain; Region: HTH_11; pfam08279
349521003791	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
349521003792	substrate binding site [chemical binding]; other site
349521003793	ATP binding site [chemical binding]; other site
349521003794	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
349521003795	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521003796	ABC-ATPase subunit  interface; other site
349521003797	dimer interface [polypeptide binding]; other site
349521003798	putative PBP binding regions; other site
349521003799	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521003800	ABC-ATPase subunit  interface; other site
349521003801	dimer interface [polypeptide binding]; other site
349521003802	putative PBP binding regions; other site
349521003803	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
349521003804	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
349521003805	siderophore binding site; other site
349521003806	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
349521003807	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
349521003808	Walker A/P-loop; other site
349521003809	ATP binding site [chemical binding]; other site
349521003810	Q-loop/lid; other site
349521003811	ABC transporter signature motif; other site
349521003812	Walker B; other site
349521003813	D-loop; other site
349521003814	H-loop/switch region; other site
349521003815	siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950
349521003816	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
349521003817	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
349521003818	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521003819	N-terminal plug; other site
349521003820	ligand-binding site [chemical binding]; other site
349521003821	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
349521003822	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349521003823	PYR/PP interface [polypeptide binding]; other site
349521003824	dimer interface [polypeptide binding]; other site
349521003825	TPP binding site [chemical binding]; other site
349521003826	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349521003827	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
349521003828	TPP-binding site [chemical binding]; other site
349521003829	DoxX-like family; Region: DoxX_3; pfam13781
349521003830	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
349521003831	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
349521003832	ADP-ribose binding site [chemical binding]; other site
349521003833	Predicted flavoprotein [General function prediction only]; Region: COG0431
349521003834	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349521003835	DinB family; Region: DinB; cl17821
349521003836	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
349521003837	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
349521003838	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
349521003839	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
349521003840	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
349521003841	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521003842	catalytic residue [active]
349521003843	FeS assembly protein SufD; Region: sufD; TIGR01981
349521003844	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
349521003845	FeS assembly ATPase SufC; Region: sufC; TIGR01978
349521003846	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
349521003847	Walker A/P-loop; other site
349521003848	ATP binding site [chemical binding]; other site
349521003849	Q-loop/lid; other site
349521003850	ABC transporter signature motif; other site
349521003851	Walker B; other site
349521003852	D-loop; other site
349521003853	H-loop/switch region; other site
349521003854	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
349521003855	putative ABC transporter; Region: ycf24; CHL00085
349521003856	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
349521003857	Transcriptional regulator; Region: Rrf2; pfam02082
349521003858	Transcriptional regulator; Region: Rrf2; cl17282
349521003859	hypothetical protein; Provisional; Region: PRK11027
349521003860	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349521003861	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
349521003862	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
349521003863	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
349521003864	apolar tunnel; other site
349521003865	heme binding site [chemical binding]; other site
349521003866	dimerization interface [polypeptide binding]; other site
349521003867	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
349521003868	HAMP domain; Region: HAMP; pfam00672
349521003869	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521003870	metal binding site [ion binding]; metal-binding site
349521003871	active site
349521003872	I-site; other site
349521003873	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521003874	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
349521003875	response regulator GlrR; Provisional; Region: PRK15115
349521003876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521003877	active site
349521003878	phosphorylation site [posttranslational modification]
349521003879	intermolecular recognition site; other site
349521003880	dimerization interface [polypeptide binding]; other site
349521003881	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521003882	Walker A motif; other site
349521003883	ATP binding site [chemical binding]; other site
349521003884	Walker B motif; other site
349521003885	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
349521003886	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521003887	dimerization interface [polypeptide binding]; other site
349521003888	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521003889	dimer interface [polypeptide binding]; other site
349521003890	phosphorylation site [posttranslational modification]
349521003891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521003892	ATP binding site [chemical binding]; other site
349521003893	Mg2+ binding site [ion binding]; other site
349521003894	G-X-G motif; other site
349521003895	BON domain; Region: BON; pfam04972
349521003896	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521003897	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521003898	ligand binding site [chemical binding]; other site
349521003899	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
349521003900	putative active site [active]
349521003901	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349521003902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521003903	TPR motif; other site
349521003904	binding surface
349521003905	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521003906	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521003907	dimerization interface [polypeptide binding]; other site
349521003908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521003909	dimer interface [polypeptide binding]; other site
349521003910	phosphorylation site [posttranslational modification]
349521003911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521003912	ATP binding site [chemical binding]; other site
349521003913	Mg2+ binding site [ion binding]; other site
349521003914	G-X-G motif; other site
349521003915	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521003916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521003917	active site
349521003918	phosphorylation site [posttranslational modification]
349521003919	intermolecular recognition site; other site
349521003920	dimerization interface [polypeptide binding]; other site
349521003921	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521003922	DNA binding site [nucleotide binding]
349521003923	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
349521003924	dimer interface [polypeptide binding]; other site
349521003925	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
349521003926	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
349521003927	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
349521003928	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
349521003929	DNA binding residues [nucleotide binding]
349521003930	dimer interface [polypeptide binding]; other site
349521003931	[2Fe-2S] cluster binding site [ion binding]; other site
349521003932	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349521003933	Predicted flavoprotein [General function prediction only]; Region: COG0431
349521003934	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
349521003935	AAA ATPase domain; Region: AAA_16; pfam13191
349521003936	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349521003937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521003938	DNA binding residues [nucleotide binding]
349521003939	dimerization interface [polypeptide binding]; other site
349521003940	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
349521003941	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
349521003942	substrate binding site [chemical binding]; other site
349521003943	catalytic Zn binding site [ion binding]; other site
349521003944	NAD binding site [chemical binding]; other site
349521003945	structural Zn binding site [ion binding]; other site
349521003946	dimer interface [polypeptide binding]; other site
349521003947	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
349521003948	S-formylglutathione hydrolase; Region: PLN02442
349521003949	Uncharacterized conserved protein [Function unknown]; Region: COG3791
349521003950	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
349521003951	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
349521003952	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521003953	Homeodomain-like domain; Region: HTH_23; cl17451
349521003954	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521003955	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521003956	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521003957	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349521003958	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521003959	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
349521003960	substrate binding pocket [chemical binding]; other site
349521003961	membrane-bound complex binding site; other site
349521003962	hinge residues; other site
349521003963	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521003964	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521003965	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
349521003966	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
349521003967	putative active site [active]
349521003968	putative FMN binding site [chemical binding]; other site
349521003969	putative substrate binding site [chemical binding]; other site
349521003970	putative catalytic residue [active]
349521003971	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
349521003972	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
349521003973	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
349521003974	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521003975	Walker A/P-loop; other site
349521003976	ATP binding site [chemical binding]; other site
349521003977	Q-loop/lid; other site
349521003978	ABC transporter signature motif; other site
349521003979	Walker B; other site
349521003980	D-loop; other site
349521003981	H-loop/switch region; other site
349521003982	TOBE domain; Region: TOBE_2; pfam08402
349521003983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
349521003984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521003985	ABC-ATPase subunit interface; other site
349521003986	putative PBP binding loops; other site
349521003987	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
349521003988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521003989	dimer interface [polypeptide binding]; other site
349521003990	conserved gate region; other site
349521003991	putative PBP binding loops; other site
349521003992	ABC-ATPase subunit interface; other site
349521003993	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
349521003994	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521003995	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521003996	substrate binding pocket [chemical binding]; other site
349521003997	membrane-bound complex binding site; other site
349521003998	hinge residues; other site
349521003999	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521004000	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
349521004001	nudix motif; other site
349521004002	SpoVR family protein; Provisional; Region: PRK11767
349521004003	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
349521004004	hypothetical protein; Provisional; Region: PRK05325
349521004005	PrkA family serine protein kinase; Provisional; Region: PRK15455
349521004006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349521004007	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
349521004008	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
349521004009	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521004010	Zn2+ binding site [ion binding]; other site
349521004011	Mg2+ binding site [ion binding]; other site
349521004012	OsmC-like protein; Region: OsmC; cl00767
349521004013	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
349521004014	Ca2+ binding site [ion binding]; other site
349521004015	Family description; Region: VCBS; pfam13517
349521004016	Family description; Region: VCBS; pfam13517
349521004017	Family description; Region: VCBS; pfam13517
349521004018	Family description; Region: VCBS; pfam13517
349521004019	FG-GAP repeat; Region: FG-GAP; pfam01839
349521004020	Family description; Region: VCBS; pfam13517
349521004021	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
349521004022	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
349521004023	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
349521004024	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
349521004025	aldehyde dehydrogenase family 7 member; Region: PLN02315
349521004026	tetrameric interface [polypeptide binding]; other site
349521004027	NAD binding site [chemical binding]; other site
349521004028	catalytic residues [active]
349521004029	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
349521004030	TrkA-N domain; Region: TrkA_N; pfam02254
349521004031	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521004032	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
349521004033	AsnC family; Region: AsnC_trans_reg; pfam01037
349521004034	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
349521004035	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
349521004036	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
349521004037	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
349521004038	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
349521004039	dimer interface [polypeptide binding]; other site
349521004040	active site residues [active]
349521004041	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
349521004042	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
349521004043	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521004044	EamA-like transporter family; Region: EamA; pfam00892
349521004045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
349521004046	SEC-C motif; Region: SEC-C; pfam02810
349521004047	SEC-C motif; Region: SEC-C; pfam02810
349521004048	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
349521004049	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
349521004050	active site
349521004051	purine riboside binding site [chemical binding]; other site
349521004052	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
349521004053	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
349521004054	putative ligand binding site [chemical binding]; other site
349521004055	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
349521004056	Ectoine synthase; Region: Ectoine_synth; pfam06339
349521004057	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
349521004058	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349521004059	inhibitor-cofactor binding pocket; inhibition site
349521004060	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521004061	catalytic residue [active]
349521004062	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521004063	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521004064	Coenzyme A binding pocket [chemical binding]; other site
349521004065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
349521004066	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
349521004067	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349521004068	Beta-Casp domain; Region: Beta-Casp; smart01027
349521004069	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
349521004070	thymidine phosphorylase; Provisional; Region: PRK04350
349521004071	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
349521004072	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
349521004073	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
349521004074	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
349521004075	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
349521004076	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521004077	active site
349521004078	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
349521004079	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
349521004080	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521004081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521004082	metal binding site [ion binding]; metal-binding site
349521004083	active site
349521004084	I-site; other site
349521004085	glycerate dehydrogenase; Provisional; Region: PRK06487
349521004086	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
349521004087	putative ligand binding site [chemical binding]; other site
349521004088	putative NAD binding site [chemical binding]; other site
349521004089	catalytic site [active]
349521004090	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
349521004091	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
349521004092	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
349521004093	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
349521004094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
349521004095	RNA methyltransferase, RsmE family; Region: TIGR00046
349521004096	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
349521004097	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
349521004098	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349521004099	inhibitor-cofactor binding pocket; inhibition site
349521004100	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521004101	catalytic residue [active]
349521004102	Cache domain; Region: Cache_1; pfam02743
349521004103	PAS domain S-box; Region: sensory_box; TIGR00229
349521004104	PAS domain; Region: PAS_8; pfam13188
349521004105	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521004106	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521004107	metal binding site [ion binding]; metal-binding site
349521004108	active site
349521004109	I-site; other site
349521004110	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521004111	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
349521004112	FAD binding site [chemical binding]; other site
349521004113	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
349521004114	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
349521004115	homotetramer interface [polypeptide binding]; other site
349521004116	ligand binding site [chemical binding]; other site
349521004117	catalytic site [active]
349521004118	NAD binding site [chemical binding]; other site
349521004119	S-adenosylmethionine synthetase; Validated; Region: PRK05250
349521004120	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
349521004121	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
349521004122	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
349521004123	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521004124	putative DNA binding site [nucleotide binding]; other site
349521004125	dimerization interface [polypeptide binding]; other site
349521004126	putative Zn2+ binding site [ion binding]; other site
349521004127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521004128	S-adenosylmethionine binding site [chemical binding]; other site
349521004129	transketolase; Reviewed; Region: PRK12753
349521004130	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
349521004131	TPP-binding site [chemical binding]; other site
349521004132	dimer interface [polypeptide binding]; other site
349521004133	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
349521004134	PYR/PP interface [polypeptide binding]; other site
349521004135	dimer interface [polypeptide binding]; other site
349521004136	TPP binding site [chemical binding]; other site
349521004137	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349521004138	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
349521004139	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
349521004140	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
349521004141	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
349521004142	Phosphoglycerate kinase; Region: PGK; pfam00162
349521004143	substrate binding site [chemical binding]; other site
349521004144	hinge regions; other site
349521004145	ADP binding site [chemical binding]; other site
349521004146	catalytic site [active]
349521004147	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
349521004148	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
349521004149	intersubunit interface [polypeptide binding]; other site
349521004150	active site
349521004151	zinc binding site [ion binding]; other site
349521004152	Na+ binding site [ion binding]; other site
349521004153	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
349521004154	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349521004155	putative outer membrane lipoprotein; Provisional; Region: PRK10510
349521004156	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521004157	ligand binding site [chemical binding]; other site
349521004158	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521004159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521004160	active site
349521004161	phosphorylation site [posttranslational modification]
349521004162	intermolecular recognition site; other site
349521004163	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
349521004164	Right handed beta helix region; Region: Beta_helix; pfam13229
349521004165	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521004166	Helix-turn-helix domain; Region: HTH_19; pfam12844
349521004167	non-specific DNA binding site [nucleotide binding]; other site
349521004168	salt bridge; other site
349521004169	sequence-specific DNA binding site [nucleotide binding]; other site
349521004170	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
349521004171	active site
349521004172	catalytic triad [active]
349521004173	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521004174	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
349521004175	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
349521004176	phosphodiesterase YaeI; Provisional; Region: PRK11340
349521004177	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
349521004178	putative active site [active]
349521004179	putative metal binding site [ion binding]; other site
349521004180	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
349521004181	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
349521004182	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
349521004183	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
349521004184	metal ion-dependent adhesion site (MIDAS); other site
349521004185	Uncharacterized conserved protein [Function unknown]; Region: COG4850
349521004186	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
349521004187	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
349521004188	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
349521004189	Methyltransferase domain; Region: Methyltransf_12; pfam08242
349521004190	DNA polymerase II; Reviewed; Region: PRK05762
349521004191	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
349521004192	active site
349521004193	catalytic site [active]
349521004194	substrate binding site [chemical binding]; other site
349521004195	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
349521004196	active site
349521004197	metal-binding site
349521004198	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
349521004199	catalytic residue [active]
349521004200	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
349521004201	Amidase; Region: Amidase; cl11426
349521004202	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521004203	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521004204	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
349521004205	putative dimerization interface [polypeptide binding]; other site
349521004206	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
349521004207	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349521004208	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
349521004209	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
349521004210	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
349521004211	TROVE domain; Region: TROVE; pfam05731
349521004212	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521004213	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
349521004214	active site
349521004215	metal binding site [ion binding]; metal-binding site
349521004216	Predicted transcriptional regulator [Transcription]; Region: COG2345
349521004217	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521004218	putative DNA binding site [nucleotide binding]; other site
349521004219	putative Zn2+ binding site [ion binding]; other site
349521004220	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521004221	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
349521004222	substrate binding site [chemical binding]; other site
349521004223	oxyanion hole (OAH) forming residues; other site
349521004224	trimer interface [polypeptide binding]; other site
349521004225	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
349521004226	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
349521004227	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
349521004228	PA/protease or protease-like domain interface [polypeptide binding]; other site
349521004229	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
349521004230	active site
349521004231	metal binding site [ion binding]; metal-binding site
349521004232	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
349521004233	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
349521004234	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521004235	Coenzyme A binding pocket [chemical binding]; other site
349521004236	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
349521004237	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
349521004238	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
349521004239	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
349521004240	Peptidase family M48; Region: Peptidase_M48; pfam01435
349521004241	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
349521004242	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349521004243	catalytic loop [active]
349521004244	iron binding site [ion binding]; other site
349521004245	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
349521004246	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349521004247	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349521004248	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349521004249	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349521004250	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349521004251	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
349521004252	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
349521004253	XdhC Rossmann domain; Region: XdhC_C; pfam13478
349521004254	Lysine efflux permease [General function prediction only]; Region: COG1279
349521004255	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
349521004256	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521004257	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521004258	dimerization interface [polypeptide binding]; other site
349521004259	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
349521004260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521004261	ATP binding site [chemical binding]; other site
349521004262	Mg2+ binding site [ion binding]; other site
349521004263	G-X-G motif; other site
349521004264	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
349521004265	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
349521004266	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
349521004267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
349521004268	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
349521004269	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
349521004270	dimer interface [polypeptide binding]; other site
349521004271	catalytic triad [active]
349521004272	peroxidatic and resolving cysteines [active]
349521004273	putative hydrolase; Provisional; Region: PRK11460
349521004274	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
349521004275	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521004276	Coenzyme A binding pocket [chemical binding]; other site
349521004277	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
349521004278	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
349521004279	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
349521004280	Walker A/P-loop; other site
349521004281	ATP binding site [chemical binding]; other site
349521004282	Q-loop/lid; other site
349521004283	ABC transporter signature motif; other site
349521004284	Walker B; other site
349521004285	D-loop; other site
349521004286	H-loop/switch region; other site
349521004287	Domain of unknown function (DUF3524); Region: DUF3524; pfam12038
349521004288	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521004289	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349521004290	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
349521004291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521004292	Walker A/P-loop; other site
349521004293	ATP binding site [chemical binding]; other site
349521004294	Q-loop/lid; other site
349521004295	ABC transporter signature motif; other site
349521004296	Walker B; other site
349521004297	D-loop; other site
349521004298	H-loop/switch region; other site
349521004299	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
349521004300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
349521004301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521004302	putative PBP binding loops; other site
349521004303	dimer interface [polypeptide binding]; other site
349521004304	ABC-ATPase subunit interface; other site
349521004305	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
349521004306	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
349521004307	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
349521004308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
349521004309	thiamine kinase; Region: ycfN_thiK; TIGR02721
349521004310	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
349521004311	active site
349521004312	substrate binding site [chemical binding]; other site
349521004313	ATP binding site [chemical binding]; other site
349521004314	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
349521004315	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521004316	dimer interface [polypeptide binding]; other site
349521004317	phosphorylation site [posttranslational modification]
349521004318	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521004319	ATP binding site [chemical binding]; other site
349521004320	Mg2+ binding site [ion binding]; other site
349521004321	G-X-G motif; other site
349521004322	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
349521004323	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
349521004324	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521004325	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521004326	metal binding site [ion binding]; metal-binding site
349521004327	active site
349521004328	I-site; other site
349521004329	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521004330	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521004331	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
349521004332	C-terminal domain interface [polypeptide binding]; other site
349521004333	GSH binding site (G-site) [chemical binding]; other site
349521004334	dimer interface [polypeptide binding]; other site
349521004335	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
349521004336	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349521004337	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521004338	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521004339	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349521004340	dimerization interface [polypeptide binding]; other site
349521004341	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
349521004342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521004343	active site
349521004344	phosphorylation site [posttranslational modification]
349521004345	intermolecular recognition site; other site
349521004346	dimerization interface [polypeptide binding]; other site
349521004347	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521004348	DNA binding residues [nucleotide binding]
349521004349	dimerization interface [polypeptide binding]; other site
349521004350	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521004351	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521004352	active site
349521004353	ATP binding site [chemical binding]; other site
349521004354	substrate binding site [chemical binding]; other site
349521004355	activation loop (A-loop); other site
349521004356	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349521004357	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349521004358	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
349521004359	putative ligand binding site [chemical binding]; other site
349521004360	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
349521004361	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
349521004362	NAD(P) binding site [chemical binding]; other site
349521004363	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
349521004364	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
349521004365	substrate-cofactor binding pocket; other site
349521004366	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521004367	catalytic residue [active]
349521004368	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521004369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521004370	non-specific DNA binding site [nucleotide binding]; other site
349521004371	salt bridge; other site
349521004372	sequence-specific DNA binding site [nucleotide binding]; other site
349521004373	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
349521004374	Cupin domain; Region: Cupin_2; pfam07883
349521004375	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
349521004376	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
349521004377	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
349521004378	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521004379	dimer interface [polypeptide binding]; other site
349521004380	phosphorylation site [posttranslational modification]
349521004381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521004382	ATP binding site [chemical binding]; other site
349521004383	Mg2+ binding site [ion binding]; other site
349521004384	G-X-G motif; other site
349521004385	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521004386	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521004387	active site
349521004388	phosphorylation site [posttranslational modification]
349521004389	intermolecular recognition site; other site
349521004390	dimerization interface [polypeptide binding]; other site
349521004391	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521004392	DNA binding site [nucleotide binding]
349521004393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
349521004394	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
349521004395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
349521004396	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
349521004397	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
349521004398	triacylglycerol lipase; Region: PLN02872
349521004399	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
349521004400	putative active site [active]
349521004401	putative metal binding site [ion binding]; other site
349521004402	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349521004403	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521004404	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521004405	dimer interface [polypeptide binding]; other site
349521004406	phosphorylation site [posttranslational modification]
349521004407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521004408	ATP binding site [chemical binding]; other site
349521004409	G-X-G motif; other site
349521004410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521004411	active site
349521004412	phosphorylation site [posttranslational modification]
349521004413	intermolecular recognition site; other site
349521004414	dimerization interface [polypeptide binding]; other site
349521004415	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349521004416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521004417	active site
349521004418	phosphorylation site [posttranslational modification]
349521004419	intermolecular recognition site; other site
349521004420	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521004421	DNA binding residues [nucleotide binding]
349521004422	dimerization interface [polypeptide binding]; other site
349521004423	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
349521004424	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
349521004425	ligand binding site [chemical binding]; other site
349521004426	NAD binding site [chemical binding]; other site
349521004427	tetramer interface [polypeptide binding]; other site
349521004428	catalytic site [active]
349521004429	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
349521004430	L-serine binding site [chemical binding]; other site
349521004431	ACT domain interface; other site
349521004432	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
349521004433	FAD binding domain; Region: FAD_binding_4; pfam01565
349521004434	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
349521004435	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
349521004436	HAMP domain; Region: HAMP; pfam00672
349521004437	dimerization interface [polypeptide binding]; other site
349521004438	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521004439	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521004440	dimer interface [polypeptide binding]; other site
349521004441	putative CheW interface [polypeptide binding]; other site
349521004442	Immunoglobulin domain; Region: Ig; cl11960
349521004443	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
349521004444	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521004445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521004446	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521004447	putative effector binding pocket; other site
349521004448	dimerization interface [polypeptide binding]; other site
349521004449	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
349521004450	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
349521004451	active site
349521004452	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
349521004453	MarR family; Region: MarR; pfam01047
349521004454	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
349521004455	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
349521004456	active site
349521004457	dimer interface [polypeptide binding]; other site
349521004458	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
349521004459	Ligand Binding Site [chemical binding]; other site
349521004460	Molecular Tunnel; other site
349521004461	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
349521004462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521004463	Coenzyme A binding pocket [chemical binding]; other site
349521004464	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349521004465	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
349521004466	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
349521004467	putative oligomer interface [polypeptide binding]; other site
349521004468	putative active site [active]
349521004469	metal binding site [ion binding]; metal-binding site
349521004470	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521004471	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
349521004472	substrate binding pocket [chemical binding]; other site
349521004473	membrane-bound complex binding site; other site
349521004474	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
349521004475	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
349521004476	putative ATP binding site [chemical binding]; other site
349521004477	putative substrate interface [chemical binding]; other site
349521004478	Response regulator receiver domain; Region: Response_reg; pfam00072
349521004479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521004480	active site
349521004481	phosphorylation site [posttranslational modification]
349521004482	intermolecular recognition site; other site
349521004483	dimerization interface [polypeptide binding]; other site
349521004484	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
349521004485	PAS fold; Region: PAS; pfam00989
349521004486	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349521004487	putative active site [active]
349521004488	heme pocket [chemical binding]; other site
349521004489	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521004490	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521004491	metal binding site [ion binding]; metal-binding site
349521004492	active site
349521004493	I-site; other site
349521004494	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
349521004495	ABC1 family; Region: ABC1; pfam03109
349521004496	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
349521004497	active site
349521004498	ATP binding site [chemical binding]; other site
349521004499	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
349521004500	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
349521004501	enoyl-CoA hydratase; Provisional; Region: PRK06142
349521004502	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521004503	substrate binding site [chemical binding]; other site
349521004504	oxyanion hole (OAH) forming residues; other site
349521004505	trimer interface [polypeptide binding]; other site
349521004506	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
349521004507	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
349521004508	active site
349521004509	catalytic site [active]
349521004510	Immunoglobulin domain; Region: Ig_2; pfam13895
349521004511	Immunoglobulin I-set domain; Region: I-set; pfam07679
349521004512	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349521004513	Interdomain contacts; other site
349521004514	Cytokine receptor motif; other site
349521004515	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
349521004516	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
349521004517	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
349521004518	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
349521004519	active site
349521004520	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
349521004521	active site 1 [active]
349521004522	dimer interface [polypeptide binding]; other site
349521004523	hexamer interface [polypeptide binding]; other site
349521004524	active site 2 [active]
349521004525	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521004526	EamA-like transporter family; Region: EamA; pfam00892
349521004527	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521004528	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
349521004529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521004530	homodimer interface [polypeptide binding]; other site
349521004531	catalytic residue [active]
349521004532	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
349521004533	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521004534	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
349521004535	active site
349521004536	metal binding site [ion binding]; metal-binding site
349521004537	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
349521004538	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
349521004539	active site
349521004540	substrate binding site [chemical binding]; other site
349521004541	FMN binding site [chemical binding]; other site
349521004542	putative catalytic residues [active]
349521004543	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349521004544	active site 2 [active]
349521004545	active site 1 [active]
349521004546	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
349521004547	Domain of unknown function DUF20; Region: UPF0118; pfam01594
349521004548	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
349521004549	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
349521004550	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521004551	active site
349521004552	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
349521004553	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521004554	RHS Repeat; Region: RHS_repeat; pfam05593
349521004555	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521004556	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
349521004557	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521004558	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521004559	RHS Repeat; Region: RHS_repeat; pfam05593
349521004560	RHS Repeat; Region: RHS_repeat; pfam05593
349521004561	RHS Repeat; Region: RHS_repeat; pfam05593
349521004562	RHS Repeat; Region: RHS_repeat; pfam05593
349521004563	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349521004564	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
349521004565	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349521004566	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
349521004567	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
349521004568	active site
349521004569	catalytic triad [active]
349521004570	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521004571	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
349521004572	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
349521004573	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521004574	Walker A motif; other site
349521004575	ATP binding site [chemical binding]; other site
349521004576	Walker B motif; other site
349521004577	arginine finger; other site
349521004578	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
349521004579	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
349521004580	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521004581	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521004582	dimerization interface [polypeptide binding]; other site
349521004583	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
349521004584	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
349521004585	metal binding site 2 [ion binding]; metal-binding site
349521004586	putative DNA binding helix; other site
349521004587	metal binding site 1 [ion binding]; metal-binding site
349521004588	dimer interface [polypeptide binding]; other site
349521004589	structural Zn2+ binding site [ion binding]; other site
349521004590	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
349521004591	dihydroorotase; Reviewed; Region: PRK09236
349521004592	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349521004593	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
349521004594	active site
349521004595	putative GTP cyclohydrolase; Provisional; Region: PRK13674
349521004596	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
349521004597	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
349521004598	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
349521004599	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521004600	exoribonuclease R; Provisional; Region: PRK11642
349521004601	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
349521004602	RNB domain; Region: RNB; pfam00773
349521004603	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
349521004604	RNA binding site [nucleotide binding]; other site
349521004605	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
349521004606	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
349521004607	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
349521004608	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
349521004609	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
349521004610	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
349521004611	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
349521004612	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
349521004613	replicative DNA helicase; Provisional; Region: PRK05748
349521004614	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
349521004615	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
349521004616	Walker A motif; other site
349521004617	ATP binding site [chemical binding]; other site
349521004618	Walker B motif; other site
349521004619	DNA binding loops [nucleotide binding]
349521004620	alanine racemase; Reviewed; Region: alr; PRK00053
349521004621	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
349521004622	active site
349521004623	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349521004624	substrate binding site [chemical binding]; other site
349521004625	catalytic residues [active]
349521004626	dimer interface [polypeptide binding]; other site
349521004627	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
349521004628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521004629	NAD(P) binding site [chemical binding]; other site
349521004630	active site
349521004631	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
349521004632	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521004633	ligand binding site [chemical binding]; other site
349521004634	flexible hinge region; other site
349521004635	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349521004636	non-specific DNA interactions [nucleotide binding]; other site
349521004637	DNA binding site [nucleotide binding]
349521004638	sequence specific DNA binding site [nucleotide binding]; other site
349521004639	putative cAMP binding site [chemical binding]; other site
349521004640	oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538
349521004641	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349521004642	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
349521004643	putative acyl-acceptor binding pocket; other site
349521004644	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521004645	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521004646	substrate binding pocket [chemical binding]; other site
349521004647	membrane-bound complex binding site; other site
349521004648	hinge residues; other site
349521004649	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521004650	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521004651	substrate binding pocket [chemical binding]; other site
349521004652	membrane-bound complex binding site; other site
349521004653	hinge residues; other site
349521004654	GTP-binding protein YchF; Reviewed; Region: PRK09601
349521004655	YchF GTPase; Region: YchF; cd01900
349521004656	G1 box; other site
349521004657	GTP/Mg2+ binding site [chemical binding]; other site
349521004658	Switch I region; other site
349521004659	G2 box; other site
349521004660	Switch II region; other site
349521004661	G3 box; other site
349521004662	G4 box; other site
349521004663	G5 box; other site
349521004664	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
349521004665	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
349521004666	putative active site [active]
349521004667	catalytic residue [active]
349521004668	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
349521004669	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
349521004670	5S rRNA interface [nucleotide binding]; other site
349521004671	CTC domain interface [polypeptide binding]; other site
349521004672	L16 interface [polypeptide binding]; other site
349521004673	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
349521004674	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
349521004675	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521004676	active site
349521004677	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
349521004678	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
349521004679	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
349521004680	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
349521004681	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521004682	TPR motif; other site
349521004683	binding surface
349521004684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521004685	binding surface
349521004686	TPR motif; other site
349521004687	TPR repeat; Region: TPR_11; pfam13414
349521004688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521004689	binding surface
349521004690	TPR motif; other site
349521004691	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
349521004692	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
349521004693	tRNA; other site
349521004694	putative tRNA binding site [nucleotide binding]; other site
349521004695	putative NADP binding site [chemical binding]; other site
349521004696	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
349521004697	peptide chain release factor 1; Validated; Region: prfA; PRK00591
349521004698	This domain is found in peptide chain release factors; Region: PCRF; smart00937
349521004699	RF-1 domain; Region: RF-1; pfam00472
349521004700	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
349521004701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521004702	S-adenosylmethionine binding site [chemical binding]; other site
349521004703	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
349521004704	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
349521004705	ATP binding site [chemical binding]; other site
349521004706	substrate interface [chemical binding]; other site
349521004707	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
349521004708	DNA photolyase; Region: DNA_photolyase; pfam00875
349521004709	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
349521004710	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
349521004711	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
349521004712	putative active site [active]
349521004713	PhoH-like protein; Region: PhoH; pfam02562
349521004714	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521004715	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521004716	FOG: CBS domain [General function prediction only]; Region: COG0517
349521004717	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
349521004718	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
349521004719	putative lipid binding site [chemical binding]; other site
349521004720	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
349521004721	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
349521004722	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
349521004723	Switch I; other site
349521004724	Switch II; other site
349521004725	septum formation inhibitor; Reviewed; Region: minC; PRK00339
349521004726	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
349521004727	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
349521004728	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
349521004729	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
349521004730	active site
349521004731	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521004732	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
349521004733	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349521004734	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349521004735	active site
349521004736	catalytic tetrad [active]
349521004737	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
349521004738	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
349521004739	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521004740	dimerization interface [polypeptide binding]; other site
349521004741	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521004742	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521004743	dimer interface [polypeptide binding]; other site
349521004744	putative CheW interface [polypeptide binding]; other site
349521004745	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
349521004746	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
349521004747	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
349521004748	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
349521004749	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349521004750	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
349521004751	putative acyl-acceptor binding pocket; other site
349521004752	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
349521004753	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
349521004754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521004755	active site
349521004756	phosphorylation site [posttranslational modification]
349521004757	intermolecular recognition site; other site
349521004758	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521004759	DNA binding site [nucleotide binding]
349521004760	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521004761	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521004762	dimerization interface [polypeptide binding]; other site
349521004763	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521004764	dimer interface [polypeptide binding]; other site
349521004765	phosphorylation site [posttranslational modification]
349521004766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521004767	ATP binding site [chemical binding]; other site
349521004768	Mg2+ binding site [ion binding]; other site
349521004769	G-X-G motif; other site
349521004770	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582
349521004771	active site
349521004772	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
349521004773	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
349521004774	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
349521004775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521004776	Walker A/P-loop; other site
349521004777	ATP binding site [chemical binding]; other site
349521004778	Q-loop/lid; other site
349521004779	ABC transporter signature motif; other site
349521004780	Walker B; other site
349521004781	D-loop; other site
349521004782	H-loop/switch region; other site
349521004783	TOBE domain; Region: TOBE_2; pfam08402
349521004784	ornithine carbamoyltransferase; Provisional; Region: PRK00779
349521004785	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
349521004786	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
349521004787	acetylornithine aminotransferase; Provisional; Region: PRK02627
349521004788	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349521004789	inhibitor-cofactor binding pocket; inhibition site
349521004790	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521004791	catalytic residue [active]
349521004792	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
349521004793	putative GSH binding site [chemical binding]; other site
349521004794	catalytic residues [active]
349521004795	TonB C terminal; Region: TonB_2; pfam13103
349521004796	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
349521004797	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
349521004798	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
349521004799	Domain of unknown function DUF21; Region: DUF21; pfam01595
349521004800	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
349521004801	Transporter associated domain; Region: CorC_HlyC; smart01091
349521004802	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
349521004803	signal recognition particle protein; Provisional; Region: PRK10867
349521004804	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
349521004805	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
349521004806	P loop; other site
349521004807	GTP binding site [chemical binding]; other site
349521004808	Signal peptide binding domain; Region: SRP_SPB; pfam02978
349521004809	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
349521004810	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
349521004811	RimM N-terminal domain; Region: RimM; pfam01782
349521004812	PRC-barrel domain; Region: PRC; pfam05239
349521004813	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
349521004814	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
349521004815	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
349521004816	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
349521004817	active site
349521004818	Int/Topo IB signature motif; other site
349521004819	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
349521004820	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
349521004821	dimerization domain [polypeptide binding]; other site
349521004822	dimer interface [polypeptide binding]; other site
349521004823	catalytic residues [active]
349521004824	aminotransferase; Validated; Region: PRK08175
349521004825	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521004826	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521004827	homodimer interface [polypeptide binding]; other site
349521004828	catalytic residue [active]
349521004829	homoserine dehydrogenase; Provisional; Region: PRK06349
349521004830	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
349521004831	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
349521004832	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
349521004833	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
349521004834	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
349521004835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521004836	catalytic residue [active]
349521004837	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
349521004838	DHH family; Region: DHH; pfam01368
349521004839	DHHA1 domain; Region: DHHA1; pfam02272
349521004840	peptide chain release factor 2; Provisional; Region: PRK08787
349521004841	This domain is found in peptide chain release factors; Region: PCRF; smart00937
349521004842	RF-1 domain; Region: RF-1; pfam00472
349521004843	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
349521004844	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
349521004845	dimer interface [polypeptide binding]; other site
349521004846	putative anticodon binding site; other site
349521004847	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
349521004848	motif 1; other site
349521004849	active site
349521004850	motif 2; other site
349521004851	motif 3; other site
349521004852	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
349521004853	ligand binding site [chemical binding]; other site
349521004854	active site
349521004855	UGI interface [polypeptide binding]; other site
349521004856	catalytic site [active]
349521004857	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
349521004858	HD domain; Region: HD; pfam01966
349521004859	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
349521004860	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
349521004861	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
349521004862	Uncharacterized conserved protein [Function unknown]; Region: COG2938
349521004863	L-aspartate oxidase; Provisional; Region: PRK09077
349521004864	L-aspartate oxidase; Provisional; Region: PRK06175
349521004865	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
349521004866	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
349521004867	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349521004868	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521004869	DNA binding residues [nucleotide binding]
349521004870	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
349521004871	anti-sigma E factor; Provisional; Region: rseB; PRK09455
349521004872	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
349521004873	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
349521004874	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
349521004875	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349521004876	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349521004877	protein binding site [polypeptide binding]; other site
349521004878	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349521004879	protein binding site [polypeptide binding]; other site
349521004880	GTP-binding protein LepA; Provisional; Region: PRK05433
349521004881	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
349521004882	G1 box; other site
349521004883	putative GEF interaction site [polypeptide binding]; other site
349521004884	GTP/Mg2+ binding site [chemical binding]; other site
349521004885	Switch I region; other site
349521004886	G2 box; other site
349521004887	G3 box; other site
349521004888	Switch II region; other site
349521004889	G4 box; other site
349521004890	G5 box; other site
349521004891	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
349521004892	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
349521004893	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
349521004894	signal peptidase I; Provisional; Region: PRK10861
349521004895	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
349521004896	Catalytic site [active]
349521004897	ribonuclease III; Reviewed; Region: rnc; PRK00102
349521004898	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
349521004899	dimerization interface [polypeptide binding]; other site
349521004900	active site
349521004901	metal binding site [ion binding]; metal-binding site
349521004902	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
349521004903	dsRNA binding site [nucleotide binding]; other site
349521004904	GTPase Era; Reviewed; Region: era; PRK00089
349521004905	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
349521004906	G1 box; other site
349521004907	GTP/Mg2+ binding site [chemical binding]; other site
349521004908	Switch I region; other site
349521004909	G2 box; other site
349521004910	Switch II region; other site
349521004911	G3 box; other site
349521004912	G4 box; other site
349521004913	G5 box; other site
349521004914	KH domain; Region: KH_2; pfam07650
349521004915	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
349521004916	Recombination protein O N terminal; Region: RecO_N; pfam11967
349521004917	Recombination protein O C terminal; Region: RecO_C; pfam02565
349521004918	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
349521004919	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521004920	dimerization interface [polypeptide binding]; other site
349521004921	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521004922	dimer interface [polypeptide binding]; other site
349521004923	phosphorylation site [posttranslational modification]
349521004924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521004925	ATP binding site [chemical binding]; other site
349521004926	Mg2+ binding site [ion binding]; other site
349521004927	G-X-G motif; other site
349521004928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521004929	active site
349521004930	phosphorylation site [posttranslational modification]
349521004931	intermolecular recognition site; other site
349521004932	dimerization interface [polypeptide binding]; other site
349521004933	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521004934	putative binding surface; other site
349521004935	active site
349521004936	cysteine synthase B; Region: cysM; TIGR01138
349521004937	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
349521004938	dimer interface [polypeptide binding]; other site
349521004939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521004940	catalytic residue [active]
349521004941	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
349521004942	TRAM domain; Region: TRAM; cl01282
349521004943	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521004944	S-adenosylmethionine binding site [chemical binding]; other site
349521004945	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
349521004946	HD domain; Region: HD_4; pfam13328
349521004947	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
349521004948	synthetase active site [active]
349521004949	NTP binding site [chemical binding]; other site
349521004950	metal binding site [ion binding]; metal-binding site
349521004951	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
349521004952	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
349521004953	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
349521004954	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
349521004955	homodimer interface [polypeptide binding]; other site
349521004956	metal binding site [ion binding]; metal-binding site
349521004957	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
349521004958	homodimer interface [polypeptide binding]; other site
349521004959	active site
349521004960	putative chemical substrate binding site [chemical binding]; other site
349521004961	metal binding site [ion binding]; metal-binding site
349521004962	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
349521004963	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
349521004964	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
349521004965	putative deacylase active site [active]
349521004966	HDOD domain; Region: HDOD; pfam08668
349521004967	adenylate kinase; Reviewed; Region: adk; PRK00279
349521004968	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
349521004969	AMP-binding site [chemical binding]; other site
349521004970	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
349521004971	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
349521004972	Glycoprotease family; Region: Peptidase_M22; pfam00814
349521004973	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
349521004974	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
349521004975	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
349521004976	EamA-like transporter family; Region: EamA; pfam00892
349521004977	EamA-like transporter family; Region: EamA; pfam00892
349521004978	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
349521004979	hypothetical protein; Provisional; Region: PRK03757
349521004980	Peptidase C13 family; Region: Peptidase_C13; cl02159
349521004981	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
349521004982	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
349521004983	Na binding site [ion binding]; other site
349521004984	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
349521004985	Proline dehydrogenase; Region: Pro_dh; pfam01619
349521004986	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
349521004987	Glutamate binding site [chemical binding]; other site
349521004988	NAD binding site [chemical binding]; other site
349521004989	catalytic residues [active]
349521004990	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521004991	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521004992	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521004993	Immunoglobulin domain; Region: Ig_2; pfam13895
349521004994	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349521004995	Interdomain contacts; other site
349521004996	Cytokine receptor motif; other site
349521004997	TraB family; Region: TraB; pfam01963
349521004998	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521004999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521005000	LysR substrate binding domain; Region: LysR_substrate; pfam03466
349521005001	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
349521005002	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521005003	Walker A/P-loop; other site
349521005004	ATP binding site [chemical binding]; other site
349521005005	Q-loop/lid; other site
349521005006	ABC transporter signature motif; other site
349521005007	Walker B; other site
349521005008	D-loop; other site
349521005009	H-loop/switch region; other site
349521005010	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
349521005011	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
349521005012	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521005013	Walker A/P-loop; other site
349521005014	ATP binding site [chemical binding]; other site
349521005015	Q-loop/lid; other site
349521005016	ABC transporter signature motif; other site
349521005017	Walker B; other site
349521005018	D-loop; other site
349521005019	H-loop/switch region; other site
349521005020	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
349521005021	dipeptide transporter; Provisional; Region: PRK10913
349521005022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521005023	dimer interface [polypeptide binding]; other site
349521005024	conserved gate region; other site
349521005025	putative PBP binding loops; other site
349521005026	ABC-ATPase subunit interface; other site
349521005027	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
349521005028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521005029	dimer interface [polypeptide binding]; other site
349521005030	conserved gate region; other site
349521005031	putative PBP binding loops; other site
349521005032	ABC-ATPase subunit interface; other site
349521005033	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
349521005034	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
349521005035	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
349521005036	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
349521005037	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349521005038	Interdomain contacts; other site
349521005039	Cytokine receptor motif; other site
349521005040	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349521005041	Interdomain contacts; other site
349521005042	Cytokine receptor motif; other site
349521005043	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349521005044	Interdomain contacts; other site
349521005045	Cytokine receptor motif; other site
349521005046	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
349521005047	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
349521005048	dimer interface [polypeptide binding]; other site
349521005049	active site
349521005050	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
349521005051	Aspartase; Region: Aspartase; cd01357
349521005052	active sites [active]
349521005053	tetramer interface [polypeptide binding]; other site
349521005054	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
349521005055	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
349521005056	Helicase; Region: Helicase_RecD; pfam05127
349521005057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521005058	Coenzyme A binding pocket [chemical binding]; other site
349521005059	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
349521005060	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
349521005061	intersubunit interface [polypeptide binding]; other site
349521005062	active site
349521005063	Zn2+ binding site [ion binding]; other site
349521005064	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
349521005065	Cupin domain; Region: Cupin_2; cl17218
349521005066	Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229
349521005067	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521005068	motif II; other site
349521005069	HAMP domain; Region: HAMP; pfam00672
349521005070	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521005071	dimer interface [polypeptide binding]; other site
349521005072	phosphorylation site [posttranslational modification]
349521005073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521005074	ATP binding site [chemical binding]; other site
349521005075	Mg2+ binding site [ion binding]; other site
349521005076	G-X-G motif; other site
349521005077	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521005078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521005079	active site
349521005080	phosphorylation site [posttranslational modification]
349521005081	intermolecular recognition site; other site
349521005082	dimerization interface [polypeptide binding]; other site
349521005083	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521005084	DNA binding site [nucleotide binding]
349521005085	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
349521005086	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
349521005087	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
349521005088	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521005089	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521005090	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
349521005091	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
349521005092	NAD(P) binding site [chemical binding]; other site
349521005093	catalytic residues [active]
349521005094	Protein of unknown function (DUF3080); Region: DUF3080; pfam11279
349521005095	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
349521005096	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
349521005097	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349521005098	Walker A motif; other site
349521005099	ATP binding site [chemical binding]; other site
349521005100	Walker B motif; other site
349521005101	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
349521005102	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
349521005103	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349521005104	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
349521005105	ArsC family; Region: ArsC; pfam03960
349521005106	catalytic residues [active]
349521005107	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
349521005108	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349521005109	catalytic residues [active]
349521005110	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
349521005111	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
349521005112	putative active site [active]
349521005113	putative PHP Thumb interface [polypeptide binding]; other site
349521005114	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
349521005115	generic binding surface I; other site
349521005116	generic binding surface II; other site
349521005117	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
349521005118	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
349521005119	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
349521005120	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
349521005121	Ligand Binding Site [chemical binding]; other site
349521005122	TilS substrate binding domain; Region: TilS; pfam09179
349521005123	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
349521005124	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
349521005125	CTP synthetase; Validated; Region: pyrG; PRK05380
349521005126	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
349521005127	Catalytic site [active]
349521005128	active site
349521005129	UTP binding site [chemical binding]; other site
349521005130	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
349521005131	active site
349521005132	putative oxyanion hole; other site
349521005133	catalytic triad [active]
349521005134	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
349521005135	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
349521005136	enolase; Provisional; Region: eno; PRK00077
349521005137	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
349521005138	dimer interface [polypeptide binding]; other site
349521005139	metal binding site [ion binding]; metal-binding site
349521005140	substrate binding pocket [chemical binding]; other site
349521005141	Septum formation initiator; Region: DivIC; cl17659
349521005142	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
349521005143	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
349521005144	substrate binding site; other site
349521005145	dimer interface; other site
349521005146	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
349521005147	homotrimer interaction site [polypeptide binding]; other site
349521005148	zinc binding site [ion binding]; other site
349521005149	CDP-binding sites; other site
349521005150	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
349521005151	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
349521005152	Permutation of conserved domain; other site
349521005153	active site
349521005154	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
349521005155	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
349521005156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521005157	S-adenosylmethionine binding site [chemical binding]; other site
349521005158	Domain of unknown function (DUF368); Region: DUF368; pfam04018
349521005159	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
349521005160	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349521005161	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521005162	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
349521005163	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
349521005164	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349521005165	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
349521005166	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521005167	DNA binding residues [nucleotide binding]
349521005168	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
349521005169	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
349521005170	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349521005171	putative active site [active]
349521005172	putative NTP binding site [chemical binding]; other site
349521005173	putative nucleic acid binding site [nucleotide binding]; other site
349521005174	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
349521005175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521005176	binding surface
349521005177	TPR motif; other site
349521005178	TPR repeat; Region: TPR_11; pfam13414
349521005179	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521005180	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521005181	DNA-binding site [nucleotide binding]; DNA binding site
349521005182	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
349521005183	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521005184	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521005185	homodimer interface [polypeptide binding]; other site
349521005186	catalytic residue [active]
349521005187	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
349521005188	endonuclease III; Provisional; Region: PRK10702
349521005189	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349521005190	minor groove reading motif; other site
349521005191	helix-hairpin-helix signature motif; other site
349521005192	substrate binding pocket [chemical binding]; other site
349521005193	active site
349521005194	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
349521005195	electron transport complex RsxE subunit; Provisional; Region: PRK12405
349521005196	FMN-binding domain; Region: FMN_bind; cl01081
349521005197	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
349521005198	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
349521005199	SLBB domain; Region: SLBB; pfam10531
349521005200	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349521005201	electron transport complex protein RnfB; Provisional; Region: PRK05113
349521005202	Putative Fe-S cluster; Region: FeS; pfam04060
349521005203	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
349521005204	electron transport complex protein RsxA; Provisional; Region: PRK05151
349521005205	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
349521005206	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
349521005207	active site
349521005208	HIGH motif; other site
349521005209	KMSKS motif; other site
349521005210	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
349521005211	tRNA binding surface [nucleotide binding]; other site
349521005212	anticodon binding site; other site
349521005213	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
349521005214	dimer interface [polypeptide binding]; other site
349521005215	putative tRNA-binding site [nucleotide binding]; other site
349521005216	antiporter inner membrane protein; Provisional; Region: PRK11670
349521005217	Domain of unknown function DUF59; Region: DUF59; pfam01883
349521005218	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
349521005219	Walker A motif; other site
349521005220	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
349521005221	trimer interface [polypeptide binding]; other site
349521005222	active site
349521005223	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
349521005224	active site
349521005225	intersubunit interface [polypeptide binding]; other site
349521005226	Zn2+ binding site [ion binding]; other site
349521005227	Protein of unknown function (DUF416); Region: DUF416; pfam04222
349521005228	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
349521005229	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521005230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521005231	homodimer interface [polypeptide binding]; other site
349521005232	catalytic residue [active]
349521005233	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
349521005234	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
349521005235	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
349521005236	active site
349521005237	substrate binding site [chemical binding]; other site
349521005238	cosubstrate binding site; other site
349521005239	catalytic site [active]
349521005240	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
349521005241	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
349521005242	dimerization interface [polypeptide binding]; other site
349521005243	putative ATP binding site [chemical binding]; other site
349521005244	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
349521005245	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
349521005246	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
349521005247	NACHT domain; Region: NACHT; pfam05729
349521005248	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349521005249	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349521005250	P-loop; other site
349521005251	Magnesium ion binding site [ion binding]; other site
349521005252	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349521005253	Magnesium ion binding site [ion binding]; other site
349521005254	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
349521005255	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
349521005256	putative uracil binding site [chemical binding]; other site
349521005257	putative active site [active]
349521005258	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
349521005259	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349521005260	putative acyl-acceptor binding pocket; other site
349521005261	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
349521005262	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
349521005263	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
349521005264	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
349521005265	MASE1; Region: MASE1; cl17823
349521005266	PAS domain S-box; Region: sensory_box; TIGR00229
349521005267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521005268	putative active site [active]
349521005269	heme pocket [chemical binding]; other site
349521005270	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521005271	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521005272	metal binding site [ion binding]; metal-binding site
349521005273	active site
349521005274	I-site; other site
349521005275	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521005276	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742
349521005277	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
349521005278	dimerization interface [polypeptide binding]; other site
349521005279	active site
349521005280	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
349521005281	catalytic motif [active]
349521005282	Catalytic residue [active]
349521005283	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
349521005284	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
349521005285	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
349521005286	amidase catalytic site [active]
349521005287	Zn binding residues [ion binding]; other site
349521005288	substrate binding site [chemical binding]; other site
349521005289	Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896
349521005290	SecY interacting protein Syd; Provisional; Region: PRK04968
349521005291	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
349521005292	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521005293	dimerization interface [polypeptide binding]; other site
349521005294	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521005295	dimer interface [polypeptide binding]; other site
349521005296	putative CheW interface [polypeptide binding]; other site
349521005297	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
349521005298	2-dehydropantoate 2-reductase; Provisional; Region: PRK05708
349521005299	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
349521005300	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
349521005301	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
349521005302	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
349521005303	HIGH motif; other site
349521005304	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
349521005305	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
349521005306	active site
349521005307	KMSKS motif; other site
349521005308	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
349521005309	tRNA binding surface [nucleotide binding]; other site
349521005310	anticodon binding site; other site
349521005311	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
349521005312	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
349521005313	multifunctional aminopeptidase A; Provisional; Region: PRK00913
349521005314	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
349521005315	interface (dimer of trimers) [polypeptide binding]; other site
349521005316	Substrate-binding/catalytic site; other site
349521005317	Zn-binding sites [ion binding]; other site
349521005318	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
349521005319	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
349521005320	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
349521005321	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
349521005322	Cache domain; Region: Cache_1; pfam02743
349521005323	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521005324	dimerization interface [polypeptide binding]; other site
349521005325	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521005326	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521005327	dimer interface [polypeptide binding]; other site
349521005328	putative CheW interface [polypeptide binding]; other site
349521005329	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521005330	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521005331	substrate binding pocket [chemical binding]; other site
349521005332	membrane-bound complex binding site; other site
349521005333	hinge residues; other site
349521005334	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521005335	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521005336	substrate binding pocket [chemical binding]; other site
349521005337	membrane-bound complex binding site; other site
349521005338	hinge residues; other site
349521005339	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349521005340	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
349521005341	putative ligand binding site [chemical binding]; other site
349521005342	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
349521005343	intracellular protease, PfpI family; Region: PfpI; TIGR01382
349521005344	conserved cys residue [active]
349521005345	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
349521005346	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
349521005347	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349521005348	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
349521005349	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
349521005350	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
349521005351	active site
349521005352	dimer interface [polypeptide binding]; other site
349521005353	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521005354	dimerization interface [polypeptide binding]; other site
349521005355	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521005356	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521005357	dimer interface [polypeptide binding]; other site
349521005358	putative CheW interface [polypeptide binding]; other site
349521005359	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
349521005360	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349521005361	conserved cys residue [active]
349521005362	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521005363	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521005364	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
349521005365	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
349521005366	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349521005367	inhibitor-cofactor binding pocket; inhibition site
349521005368	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521005369	catalytic residue [active]
349521005370	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
349521005371	arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245
349521005372	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
349521005373	arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244
349521005374	succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240
349521005375	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
349521005376	NAD(P) binding site [chemical binding]; other site
349521005377	catalytic residues [active]
349521005378	succinylarginine dihydrolase; Provisional; Region: PRK13281
349521005379	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349521005380	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521005381	active site
349521005382	ATP binding site [chemical binding]; other site
349521005383	substrate binding site [chemical binding]; other site
349521005384	activation loop (A-loop); other site
349521005385	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
349521005386	active site
349521005387	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
349521005388	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
349521005389	phosphopeptide binding site; other site
349521005390	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
349521005391	MG2 domain; Region: A2M_N; pfam01835
349521005392	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
349521005393	surface patch; other site
349521005394	thioester region; other site
349521005395	specificity defining residues; other site
349521005396	penicillin-binding protein 1C; Provisional; Region: PRK11240
349521005397	Transglycosylase; Region: Transgly; pfam00912
349521005398	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
349521005399	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
349521005400	HD domain; Region: HD_3; pfam13023
349521005401	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
349521005402	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
349521005403	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521005404	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521005405	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
349521005406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521005407	Walker A/P-loop; other site
349521005408	ATP binding site [chemical binding]; other site
349521005409	Q-loop/lid; other site
349521005410	ABC transporter signature motif; other site
349521005411	Walker B; other site
349521005412	D-loop; other site
349521005413	H-loop/switch region; other site
349521005414	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349521005415	Walker A/P-loop; other site
349521005416	ATP binding site [chemical binding]; other site
349521005417	Q-loop/lid; other site
349521005418	ABC transporter signature motif; other site
349521005419	Walker B; other site
349521005420	D-loop; other site
349521005421	H-loop/switch region; other site
349521005422	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
349521005423	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
349521005424	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
349521005425	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
349521005426	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
349521005427	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
349521005428	putative deacylase active site [active]
349521005429	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
349521005430	ADP-ribose binding site [chemical binding]; other site
349521005431	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521005432	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521005433	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521005434	RHS Repeat; Region: RHS_repeat; pfam05593
349521005435	RHS Repeat; Region: RHS_repeat; pfam05593
349521005436	RHS Repeat; Region: RHS_repeat; pfam05593
349521005437	RHS Repeat; Region: RHS_repeat; pfam05593
349521005438	RHS Repeat; Region: RHS_repeat; pfam05593
349521005439	RHS protein; Region: RHS; pfam03527
349521005440	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521005441	GRAM domain; Region: GRAM; pfam02893
349521005442	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521005443	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
349521005444	catalytic site [active]
349521005445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521005446	malonic semialdehyde reductase; Provisional; Region: PRK10538
349521005447	NAD(P) binding site [chemical binding]; other site
349521005448	active site
349521005449	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
349521005450	NAD(P) binding site [chemical binding]; other site
349521005451	substrate binding site [chemical binding]; other site
349521005452	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521005453	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
349521005454	substrate binding pocket [chemical binding]; other site
349521005455	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
349521005456	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
349521005457	metal binding site [ion binding]; metal-binding site
349521005458	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
349521005459	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
349521005460	dimer interface [polypeptide binding]; other site
349521005461	PYR/PP interface [polypeptide binding]; other site
349521005462	TPP binding site [chemical binding]; other site
349521005463	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349521005464	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
349521005465	TPP-binding site [chemical binding]; other site
349521005466	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349521005467	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
349521005468	hypothetical protein; Provisional; Region: PRK00967
349521005469	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
349521005470	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521005471	Walker A/P-loop; other site
349521005472	ATP binding site [chemical binding]; other site
349521005473	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
349521005474	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
349521005475	Catalytic site; other site
349521005476	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
349521005477	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521005478	Coenzyme A binding pocket [chemical binding]; other site
349521005479	DivIVA protein; Region: DivIVA; pfam05103
349521005480	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
349521005481	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
349521005482	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
349521005483	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
349521005484	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521005485	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521005486	metal binding site [ion binding]; metal-binding site
349521005487	active site
349521005488	I-site; other site
349521005489	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521005490	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
349521005491	EamA-like transporter family; Region: EamA; pfam00892
349521005492	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
349521005493	Cupin domain; Region: Cupin_2; cl17218
349521005494	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521005495	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521005496	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521005497	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
349521005498	Part of AAA domain; Region: AAA_19; pfam13245
349521005499	Family description; Region: UvrD_C_2; pfam13538
349521005500	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521005501	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521005502	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461
349521005503	putative substrate binding pocket [chemical binding]; other site
349521005504	putative dimerization interface [polypeptide binding]; other site
349521005505	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
349521005506	homotrimer interaction site [polypeptide binding]; other site
349521005507	putative active site [active]
349521005508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
349521005509	NMT1/THI5 like; Region: NMT1; pfam09084
349521005510	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521005511	PAS domain; Region: PAS_9; pfam13426
349521005512	putative active site [active]
349521005513	heme pocket [chemical binding]; other site
349521005514	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521005515	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521005516	metal binding site [ion binding]; metal-binding site
349521005517	active site
349521005518	I-site; other site
349521005519	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521005520	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
349521005521	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
349521005522	putative DNA binding site [nucleotide binding]; other site
349521005523	catalytic residue [active]
349521005524	putative H2TH interface [polypeptide binding]; other site
349521005525	putative catalytic residues [active]
349521005526	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
349521005527	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
349521005528	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521005529	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521005530	substrate binding pocket [chemical binding]; other site
349521005531	membrane-bound complex binding site; other site
349521005532	hinge residues; other site
349521005533	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521005534	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521005535	substrate binding pocket [chemical binding]; other site
349521005536	membrane-bound complex binding site; other site
349521005537	hinge residues; other site
349521005538	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
349521005539	Predicted transcriptional regulator [Transcription]; Region: COG2378
349521005540	HTH domain; Region: HTH_11; pfam08279
349521005541	WYL domain; Region: WYL; pfam13280
349521005542	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
349521005543	putative dimer interface [polypeptide binding]; other site
349521005544	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521005545	Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435
349521005546	Protein of unknown function, DUF393; Region: DUF393; pfam04134
349521005547	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
349521005548	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
349521005549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521005550	NAD(P) binding site [chemical binding]; other site
349521005551	active site
349521005552	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
349521005553	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
349521005554	nucleophilic elbow; other site
349521005555	catalytic triad; other site
349521005556	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
349521005557	classical (c) SDRs; Region: SDR_c; cd05233
349521005558	NAD(P) binding site [chemical binding]; other site
349521005559	active site
349521005560	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521005561	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521005562	acyl-activating enzyme (AAE) consensus motif; other site
349521005563	AMP binding site [chemical binding]; other site
349521005564	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521005565	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
349521005566	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521005567	acyl-activating enzyme (AAE) consensus motif; other site
349521005568	AMP binding site [chemical binding]; other site
349521005569	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521005570	Condensation domain; Region: Condensation; pfam00668
349521005571	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521005572	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
349521005573	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521005574	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521005575	acyl-activating enzyme (AAE) consensus motif; other site
349521005576	AMP binding site [chemical binding]; other site
349521005577	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521005578	Condensation domain; Region: Condensation; pfam00668
349521005579	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521005580	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521005581	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
349521005582	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
349521005583	AzlC protein; Region: AzlC; cl00570
349521005584	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
349521005585	Predicted amidohydrolase [General function prediction only]; Region: COG0388
349521005586	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
349521005587	active site
349521005588	catalytic triad [active]
349521005589	dimer interface [polypeptide binding]; other site
349521005590	Putative integral membrane protein DUF46; Region: DUF46; cl17511
349521005591	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
349521005592	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521005593	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521005594	Walker A/P-loop; other site
349521005595	ATP binding site [chemical binding]; other site
349521005596	Q-loop/lid; other site
349521005597	ABC transporter signature motif; other site
349521005598	Walker B; other site
349521005599	D-loop; other site
349521005600	H-loop/switch region; other site
349521005601	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
349521005602	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521005603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521005604	Walker A/P-loop; other site
349521005605	ATP binding site [chemical binding]; other site
349521005606	Q-loop/lid; other site
349521005607	ABC transporter signature motif; other site
349521005608	Walker B; other site
349521005609	D-loop; other site
349521005610	H-loop/switch region; other site
349521005611	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
349521005612	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
349521005613	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349521005614	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
349521005615	putative acyl-acceptor binding pocket; other site
349521005616	EamA-like transporter family; Region: EamA; pfam00892
349521005617	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
349521005618	EamA-like transporter family; Region: EamA; pfam00892
349521005619	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
349521005620	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
349521005621	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521005622	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349521005623	HDOD domain; Region: HDOD; pfam08668
349521005624	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
349521005625	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
349521005626	active site
349521005627	phosphate binding residues; other site
349521005628	catalytic residues [active]
349521005629	Isochorismatase family; Region: Isochorismatase; pfam00857
349521005630	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
349521005631	catalytic triad [active]
349521005632	dimer interface [polypeptide binding]; other site
349521005633	conserved cis-peptide bond; other site
349521005634	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
349521005635	muropeptide transporter; Validated; Region: ampG; cl17669
349521005636	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
349521005637	classical (c) SDRs; Region: SDR_c; cd05233
349521005638	NAD(P) binding site [chemical binding]; other site
349521005639	active site
349521005640	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
349521005641	ABC1 family; Region: ABC1; cl17513
349521005642	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
349521005643	active site
349521005644	ATP binding site [chemical binding]; other site
349521005645	Protein of unknown function (DUF3135); Region: DUF3135; pfam11333
349521005646	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
349521005647	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349521005648	active site
349521005649	heat shock protein 90; Provisional; Region: PRK05218
349521005650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521005651	ATP binding site [chemical binding]; other site
349521005652	Mg2+ binding site [ion binding]; other site
349521005653	G-X-G motif; other site
349521005654	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
349521005655	LexA repressor; Validated; Region: PRK00215
349521005656	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
349521005657	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
349521005658	Catalytic site [active]
349521005659	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
349521005660	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
349521005661	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
349521005662	Family description; Region: VCBS; pfam13517
349521005663	Family description; Region: VCBS; pfam13517
349521005664	Family description; Region: VCBS; pfam13517
349521005665	Family description; Region: VCBS; pfam13517
349521005666	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521005667	RHS Repeat; Region: RHS_repeat; pfam05593
349521005668	RHS Repeat; Region: RHS_repeat; pfam05593
349521005669	RHS Repeat; Region: RHS_repeat; pfam05593
349521005670	RHS Repeat; Region: RHS_repeat; pfam05593
349521005671	RHS Repeat; Region: RHS_repeat; pfam05593
349521005672	RHS Repeat; Region: RHS_repeat; pfam05593
349521005673	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521005674	RHS Repeat; Region: RHS_repeat; pfam05593
349521005675	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521005676	RHS Repeat; Region: RHS_repeat; pfam05593
349521005677	RHS Repeat; Region: RHS_repeat; pfam05593
349521005678	RHS Repeat; Region: RHS_repeat; pfam05593
349521005679	RHS Repeat; Region: RHS_repeat; pfam05593
349521005680	RHS Repeat; Region: RHS_repeat; pfam05593
349521005681	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521005682	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
349521005683	protein-splicing catalytic site; other site
349521005684	thioester formation/cholesterol transfer; other site
349521005685	Pretoxin HINT domain; Region: PT-HINT; pfam07591
349521005686	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
349521005687	RHS Repeat; Region: RHS_repeat; pfam05593
349521005688	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521005689	GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541
349521005690	GIY-YIG motif/motif A; other site
349521005691	active site
349521005692	catalytic site [active]
349521005693	PRRSV putative envelope protein; Region: PRRSV_Env; pfam02340
349521005694	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521005695	RHS Repeat; Region: RHS_repeat; pfam05593
349521005696	RHS Repeat; Region: RHS_repeat; pfam05593
349521005697	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521005698	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
349521005699	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521005700	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
349521005701	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521005702	RHS Repeat; Region: RHS_repeat; pfam05593
349521005703	RHS Repeat; Region: RHS_repeat; pfam05593
349521005704	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521005705	RHS Repeat; Region: RHS_repeat; pfam05593
349521005706	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521005707	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
349521005708	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521005709	RHS Repeat; Region: RHS_repeat; pfam05593
349521005710	RHS Repeat; Region: RHS_repeat; pfam05593
349521005711	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521005712	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521005713	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521005714	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349521005715	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349521005716	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349521005717	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349521005718	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
349521005719	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
349521005720	conserved cys residue [active]
349521005721	CHASE4 domain; Region: CHASE4; pfam05228
349521005722	HAMP domain; Region: HAMP; pfam00672
349521005723	dimerization interface [polypeptide binding]; other site
349521005724	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521005725	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521005726	metal binding site [ion binding]; metal-binding site
349521005727	active site
349521005728	I-site; other site
349521005729	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
349521005730	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
349521005731	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
349521005732	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521005733	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521005734	metal binding site [ion binding]; metal-binding site
349521005735	active site
349521005736	I-site; other site
349521005737	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521005738	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
349521005739	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
349521005740	HIGH motif; other site
349521005741	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
349521005742	active site
349521005743	KMSKS motif; other site
349521005744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521005745	putative substrate translocation pore; other site
349521005746	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
349521005747	putative acyl-acceptor binding pocket; other site
349521005748	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
349521005749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521005750	Response regulator receiver domain; Region: Response_reg; pfam00072
349521005751	active site
349521005752	phosphorylation site [posttranslational modification]
349521005753	intermolecular recognition site; other site
349521005754	dimerization interface [polypeptide binding]; other site
349521005755	PEGA domain; Region: PEGA; pfam08308
349521005756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
349521005757	MORN repeat; Region: MORN; cl14787
349521005758	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
349521005759	active site
349521005760	dimer interfaces [polypeptide binding]; other site
349521005761	catalytic residues [active]
349521005762	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
349521005763	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
349521005764	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
349521005765	Peptidase M16C associated; Region: M16C_assoc; pfam08367
349521005766	PEP synthetase regulatory protein; Provisional; Region: PRK05339
349521005767	phosphoenolpyruvate synthase; Validated; Region: PRK06464
349521005768	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
349521005769	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349521005770	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
349521005771	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
349521005772	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
349521005773	NAD binding site [chemical binding]; other site
349521005774	active site
349521005775	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
349521005776	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
349521005777	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349521005778	putative active site [active]
349521005779	putative NTP binding site [chemical binding]; other site
349521005780	putative nucleic acid binding site [nucleotide binding]; other site
349521005781	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
349521005782	PilZ domain; Region: PilZ; pfam07238
349521005783	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
349521005784	YciI-like protein; Reviewed; Region: PRK11370
349521005785	intracellular septation protein A; Reviewed; Region: PRK00259
349521005786	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
349521005787	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
349521005788	active site
349521005789	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
349521005790	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
349521005791	putative active site [active]
349521005792	catalytic site [active]
349521005793	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
349521005794	PLD-like domain; Region: PLDc_2; pfam13091
349521005795	putative active site [active]
349521005796	catalytic site [active]
349521005797	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
349521005798	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
349521005799	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
349521005800	homodimer interface [polypeptide binding]; other site
349521005801	oligonucleotide binding site [chemical binding]; other site
349521005802	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
349521005803	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349521005804	RNA binding surface [nucleotide binding]; other site
349521005805	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349521005806	active site
349521005807	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
349521005808	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521005809	motif II; other site
349521005810	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
349521005811	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
349521005812	tandem repeat interface [polypeptide binding]; other site
349521005813	oligomer interface [polypeptide binding]; other site
349521005814	active site residues [active]
349521005815	Maf-like protein; Region: Maf; pfam02545
349521005816	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
349521005817	active site
349521005818	dimer interface [polypeptide binding]; other site
349521005819	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
349521005820	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
349521005821	putative phosphate acyltransferase; Provisional; Region: PRK05331
349521005822	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
349521005823	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
349521005824	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
349521005825	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
349521005826	NAD(P) binding site [chemical binding]; other site
349521005827	homotetramer interface [polypeptide binding]; other site
349521005828	homodimer interface [polypeptide binding]; other site
349521005829	active site
349521005830	acyl carrier protein; Provisional; Region: acpP; PRK00982
349521005831	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
349521005832	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
349521005833	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521005834	catalytic residue [active]
349521005835	YceG-like family; Region: YceG; pfam02618
349521005836	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
349521005837	dimerization interface [polypeptide binding]; other site
349521005838	thymidylate kinase; Validated; Region: tmk; PRK00698
349521005839	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
349521005840	TMP-binding site; other site
349521005841	ATP-binding site [chemical binding]; other site
349521005842	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
349521005843	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
349521005844	substrate binding site [chemical binding]; other site
349521005845	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
349521005846	substrate binding site [chemical binding]; other site
349521005847	ligand binding site [chemical binding]; other site
349521005848	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
349521005849	active site
349521005850	dinuclear metal binding site [ion binding]; other site
349521005851	dimerization interface [polypeptide binding]; other site
349521005852	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521005853	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
349521005854	putative active site [active]
349521005855	putative metal binding site [ion binding]; other site
349521005856	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
349521005857	substrate binding site [chemical binding]; other site
349521005858	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
349521005859	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349521005860	active site
349521005861	HIGH motif; other site
349521005862	nucleotide binding site [chemical binding]; other site
349521005863	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
349521005864	KMSKS motif; other site
349521005865	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
349521005866	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
349521005867	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
349521005868	active site
349521005869	HIGH motif; other site
349521005870	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
349521005871	KMSKS motif; other site
349521005872	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
349521005873	tRNA binding surface [nucleotide binding]; other site
349521005874	anticodon binding site; other site
349521005875	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
349521005876	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
349521005877	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
349521005878	homodimer interface [polypeptide binding]; other site
349521005879	NADP binding site [chemical binding]; other site
349521005880	substrate binding site [chemical binding]; other site
349521005881	trigger factor; Provisional; Region: tig; PRK01490
349521005882	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
349521005883	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
349521005884	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
349521005885	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
349521005886	oligomer interface [polypeptide binding]; other site
349521005887	active site residues [active]
349521005888	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
349521005889	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
349521005890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521005891	Walker A motif; other site
349521005892	ATP binding site [chemical binding]; other site
349521005893	Walker B motif; other site
349521005894	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349521005895	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
349521005896	Found in ATP-dependent protease La (LON); Region: LON; smart00464
349521005897	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521005898	Walker A motif; other site
349521005899	ATP binding site [chemical binding]; other site
349521005900	Walker B motif; other site
349521005901	arginine finger; other site
349521005902	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
349521005903	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349521005904	IHF dimer interface [polypeptide binding]; other site
349521005905	IHF - DNA interface [nucleotide binding]; other site
349521005906	periplasmic folding chaperone; Provisional; Region: PRK10788
349521005907	SurA N-terminal domain; Region: SurA_N_3; cl07813
349521005908	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
349521005909	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
349521005910	putative active site [active]
349521005911	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
349521005912	Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148
349521005913	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
349521005914	putative active site [active]
349521005915	putative metal binding site [ion binding]; other site
349521005916	DNA-J related protein; Region: DNAJ_related; pfam12339
349521005917	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349521005918	HSP70 interaction site [polypeptide binding]; other site
349521005919	Protein of unknown function, DUF547; Region: DUF547; pfam04784
349521005920	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
349521005921	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
349521005922	Ligand Binding Site [chemical binding]; other site
349521005923	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
349521005924	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
349521005925	NAD(P) binding site [chemical binding]; other site
349521005926	catalytic residues [active]
349521005927	acetolactate synthase; Reviewed; Region: PRK08322
349521005928	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349521005929	PYR/PP interface [polypeptide binding]; other site
349521005930	dimer interface [polypeptide binding]; other site
349521005931	TPP binding site [chemical binding]; other site
349521005932	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349521005933	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
349521005934	TPP-binding site [chemical binding]; other site
349521005935	dimer interface [polypeptide binding]; other site
349521005936	MASE1; Region: MASE1; pfam05231
349521005937	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
349521005938	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349521005939	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521005940	putative active site [active]
349521005941	heme pocket [chemical binding]; other site
349521005942	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521005943	dimer interface [polypeptide binding]; other site
349521005944	phosphorylation site [posttranslational modification]
349521005945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521005946	ATP binding site [chemical binding]; other site
349521005947	Mg2+ binding site [ion binding]; other site
349521005948	G-X-G motif; other site
349521005949	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
349521005950	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
349521005951	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
349521005952	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
349521005953	carboxy-terminal protease; Provisional; Region: PRK11186
349521005954	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
349521005955	protein binding site [polypeptide binding]; other site
349521005956	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
349521005957	Catalytic dyad [active]
349521005958	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
349521005959	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
349521005960	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521005961	substrate binding site [chemical binding]; other site
349521005962	oxyanion hole (OAH) forming residues; other site
349521005963	trimer interface [polypeptide binding]; other site
349521005964	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
349521005965	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349521005966	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
349521005967	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349521005968	dimer interface [polypeptide binding]; other site
349521005969	active site
349521005970	Late competence development protein ComFB; Region: ComFB; pfam10719
349521005971	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
349521005972	recombination regulator RecX; Reviewed; Region: recX; PRK00117
349521005973	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
349521005974	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521005975	substrate binding pocket [chemical binding]; other site
349521005976	membrane-bound complex binding site; other site
349521005977	hinge residues; other site
349521005978	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349521005979	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349521005980	catalytic residue [active]
349521005981	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
349521005982	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
349521005983	dimerization interface [polypeptide binding]; other site
349521005984	ATP binding site [chemical binding]; other site
349521005985	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
349521005986	dimerization interface [polypeptide binding]; other site
349521005987	ATP binding site [chemical binding]; other site
349521005988	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
349521005989	putative active site [active]
349521005990	catalytic triad [active]
349521005991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
349521005992	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
349521005993	nudix motif; other site
349521005994	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
349521005995	putative active site [active]
349521005996	putative CoA binding site [chemical binding]; other site
349521005997	nudix motif; other site
349521005998	metal binding site [ion binding]; metal-binding site
349521005999	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
349521006000	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
349521006001	trimer interface [polypeptide binding]; other site
349521006002	putative metal binding site [ion binding]; other site
349521006003	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
349521006004	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
349521006005	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
349521006006	NAD binding site [chemical binding]; other site
349521006007	ATP-grasp domain; Region: ATP-grasp; pfam02222
349521006008	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
349521006009	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
349521006010	putative active site [active]
349521006011	putative PHP Thumb interface [polypeptide binding]; other site
349521006012	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
349521006013	generic binding surface I; other site
349521006014	generic binding surface II; other site
349521006015	DNA Polymerase Y-family; Region: PolY_like; cd03468
349521006016	active site
349521006017	DNA binding site [nucleotide binding]
349521006018	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
349521006019	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521006020	Coenzyme A binding pocket [chemical binding]; other site
349521006021	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
349521006022	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
349521006023	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
349521006024	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
349521006025	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
349521006026	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521006027	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
349521006028	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
349521006029	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
349521006030	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
349521006031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521006032	dimer interface [polypeptide binding]; other site
349521006033	conserved gate region; other site
349521006034	putative PBP binding loops; other site
349521006035	ABC-ATPase subunit interface; other site
349521006036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521006037	dimer interface [polypeptide binding]; other site
349521006038	conserved gate region; other site
349521006039	ABC-ATPase subunit interface; other site
349521006040	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
349521006041	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
349521006042	Walker A/P-loop; other site
349521006043	ATP binding site [chemical binding]; other site
349521006044	Q-loop/lid; other site
349521006045	ABC transporter signature motif; other site
349521006046	Walker B; other site
349521006047	D-loop; other site
349521006048	H-loop/switch region; other site
349521006049	TOBE domain; Region: TOBE_2; pfam08402
349521006050	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521006051	putative protease; Provisional; Region: PRK15447
349521006052	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
349521006053	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
349521006054	Peptidase family U32; Region: Peptidase_U32; pfam01136
349521006055	SCP-2 sterol transfer family; Region: SCP2; cl01225
349521006056	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349521006057	multidrug efflux protein; Reviewed; Region: PRK09579
349521006058	Protein export membrane protein; Region: SecD_SecF; cl14618
349521006059	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521006060	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521006061	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
349521006062	Surface antigen; Region: Bac_surface_Ag; pfam01103
349521006063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
349521006064	Family of unknown function (DUF490); Region: DUF490; pfam04357
349521006065	Family of unknown function (DUF490); Region: DUF490; pfam04357
349521006066	Flavin Reductases; Region: FlaRed; cl00801
349521006067	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
349521006068	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
349521006069	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521006070	S-adenosylmethionine binding site [chemical binding]; other site
349521006071	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
349521006072	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349521006073	active site
349521006074	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
349521006075	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
349521006076	Predicted integral membrane protein [Function unknown]; Region: COG5615
349521006077	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349521006078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521006079	S-adenosylmethionine binding site [chemical binding]; other site
349521006080	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
349521006081	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
349521006082	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
349521006083	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
349521006084	Walker A/P-loop; other site
349521006085	ATP binding site [chemical binding]; other site
349521006086	Q-loop/lid; other site
349521006087	ABC transporter signature motif; other site
349521006088	Walker B; other site
349521006089	D-loop; other site
349521006090	H-loop/switch region; other site
349521006091	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
349521006092	putative carbohydrate binding site [chemical binding]; other site
349521006093	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349521006094	active site
349521006095	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521006096	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521006097	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349521006098	UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264
349521006099	putative NAD(P) binding site [chemical binding]; other site
349521006100	active site
349521006101	putative substrate binding site [chemical binding]; other site
349521006102	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349521006103	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349521006104	active site
349521006105	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
349521006106	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
349521006107	Probable Catalytic site; other site
349521006108	metal-binding site
349521006109	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
349521006110	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521006111	S-adenosylmethionine binding site [chemical binding]; other site
349521006112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521006113	S-adenosylmethionine binding site [chemical binding]; other site
349521006114	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
349521006115	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
349521006116	putative dimer interface [polypeptide binding]; other site
349521006117	putative anticodon binding site; other site
349521006118	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
349521006119	homodimer interface [polypeptide binding]; other site
349521006120	motif 1; other site
349521006121	motif 2; other site
349521006122	active site
349521006123	motif 3; other site
349521006124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521006125	Response regulator receiver domain; Region: Response_reg; pfam00072
349521006126	active site
349521006127	phosphorylation site [posttranslational modification]
349521006128	intermolecular recognition site; other site
349521006129	dimerization interface [polypeptide binding]; other site
349521006130	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521006131	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
349521006132	putative active site [active]
349521006133	putative metal binding site [ion binding]; other site
349521006134	methionine sulfoxide reductase A; Provisional; Region: PRK00058
349521006135	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
349521006136	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
349521006137	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
349521006138	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
349521006139	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521006140	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
349521006141	ADP-ribose binding site [chemical binding]; other site
349521006142	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349521006143	Cupin domain; Region: Cupin_2; pfam07883
349521006144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521006145	S-adenosylmethionine binding site [chemical binding]; other site
349521006146	Predicted transcriptional regulator [Transcription]; Region: COG1959
349521006147	Transcriptional regulator; Region: Rrf2; pfam02082
349521006148	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
349521006149	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521006150	FeS/SAM binding site; other site
349521006151	HemN C-terminal domain; Region: HemN_C; pfam06969
349521006152	Family description; Region: DsbD_2; pfam13386
349521006153	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
349521006154	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
349521006155	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
349521006156	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
349521006157	metal-binding site [ion binding]
349521006158	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349521006159	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521006160	motif II; other site
349521006161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
349521006162	FixH; Region: FixH; pfam05751
349521006163	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
349521006164	4Fe-4S binding domain; Region: Fer4_5; pfam12801
349521006165	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349521006166	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
349521006167	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
349521006168	Cytochrome c; Region: Cytochrom_C; pfam00034
349521006169	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349521006170	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
349521006171	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
349521006172	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
349521006173	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
349521006174	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
349521006175	Low-spin heme binding site [chemical binding]; other site
349521006176	Putative water exit pathway; other site
349521006177	Binuclear center (active site) [active]
349521006178	Putative proton exit pathway; other site
349521006179	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
349521006180	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
349521006181	FtsJ-like methyltransferase; Region: FtsJ; cl17430
349521006182	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
349521006183	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
349521006184	CPxP  motif; other site
349521006185	EamA-like transporter family; Region: EamA; pfam00892
349521006186	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
349521006187	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
349521006188	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
349521006189	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
349521006190	DsbD alpha interface [polypeptide binding]; other site
349521006191	catalytic residues [active]
349521006192	Protein of unknown function, DUF462; Region: DUF462; pfam04315
349521006193	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
349521006194	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
349521006195	Protein of unknown function, DUF462; Region: DUF462; cl01190
349521006196	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
349521006197	DEAD-like helicases superfamily; Region: DEXDc; smart00487
349521006198	ATP binding site [chemical binding]; other site
349521006199	Mg++ binding site [ion binding]; other site
349521006200	motif III; other site
349521006201	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521006202	nucleotide binding region [chemical binding]; other site
349521006203	ATP-binding site [chemical binding]; other site
349521006204	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
349521006205	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
349521006206	ligand binding site [chemical binding]; other site
349521006207	NAD binding site [chemical binding]; other site
349521006208	catalytic site [active]
349521006209	homodimer interface [polypeptide binding]; other site
349521006210	Flagellar protein YcgR; Region: YcgR_2; pfam12945
349521006211	PilZ domain; Region: PilZ; pfam07238
349521006212	heat shock protein HtpX; Provisional; Region: PRK05457
349521006213	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
349521006214	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521006215	The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484
349521006216	putative dimerization interface [polypeptide binding]; other site
349521006217	putative substrate binding pocket [chemical binding]; other site
349521006218	beta-lactamase TEM; Provisional; Region: PRK15442
349521006219	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
349521006220	aminotransferase AlaT; Validated; Region: PRK09265
349521006221	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521006222	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521006223	homodimer interface [polypeptide binding]; other site
349521006224	catalytic residue [active]
349521006225	methionine sulfoxide reductase B; Provisional; Region: PRK00222
349521006226	SelR domain; Region: SelR; pfam01641
349521006227	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
349521006228	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
349521006229	catalytic residues [active]
349521006230	dimer interface [polypeptide binding]; other site
349521006231	Transcriptional regulators [Transcription]; Region: MarR; COG1846
349521006232	MarR family; Region: MarR; pfam01047
349521006233	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
349521006234	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
349521006235	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521006236	dimer interface [polypeptide binding]; other site
349521006237	phosphorylation site [posttranslational modification]
349521006238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521006239	ATP binding site [chemical binding]; other site
349521006240	Mg2+ binding site [ion binding]; other site
349521006241	G-X-G motif; other site
349521006242	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521006243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521006244	active site
349521006245	phosphorylation site [posttranslational modification]
349521006246	intermolecular recognition site; other site
349521006247	dimerization interface [polypeptide binding]; other site
349521006248	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349521006249	catalytic core [active]
349521006250	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
349521006251	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
349521006252	ligand binding site [chemical binding]; other site
349521006253	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
349521006254	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349521006255	Walker A/P-loop; other site
349521006256	ATP binding site [chemical binding]; other site
349521006257	Q-loop/lid; other site
349521006258	ABC transporter signature motif; other site
349521006259	Walker B; other site
349521006260	D-loop; other site
349521006261	H-loop/switch region; other site
349521006262	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349521006263	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349521006264	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
349521006265	TM-ABC transporter signature motif; other site
349521006266	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349521006267	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
349521006268	TM-ABC transporter signature motif; other site
349521006269	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349521006270	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
349521006271	substrate binding site [chemical binding]; other site
349521006272	dimer interface [polypeptide binding]; other site
349521006273	ATP binding site [chemical binding]; other site
349521006274	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
349521006275	active site
349521006276	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
349521006277	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
349521006278	active site
349521006279	metal binding site [ion binding]; metal-binding site
349521006280	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
349521006281	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
349521006282	Phosphoesterase family; Region: Phosphoesterase; pfam04185
349521006283	isocitrate lyase; Provisional; Region: PRK15063
349521006284	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
349521006285	tetramer interface [polypeptide binding]; other site
349521006286	active site
349521006287	Mg2+/Mn2+ binding site [ion binding]; other site
349521006288	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521006289	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521006290	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
349521006291	substrate binding pocket [chemical binding]; other site
349521006292	dimerization interface [polypeptide binding]; other site
349521006293	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
349521006294	flexible hinge region; other site
349521006295	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349521006296	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521006297	ligand binding site [chemical binding]; other site
349521006298	flexible hinge region; other site
349521006299	FecR protein; Region: FecR; pfam04773
349521006300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521006301	TPR motif; other site
349521006302	binding surface
349521006303	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349521006304	Protein of unknown function (DUF560); Region: DUF560; pfam04575
349521006305	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
349521006306	CHASE2 domain; Region: CHASE2; pfam05226
349521006307	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
349521006308	cyclase homology domain; Region: CHD; cd07302
349521006309	nucleotidyl binding site; other site
349521006310	metal binding site [ion binding]; metal-binding site
349521006311	dimer interface [polypeptide binding]; other site
349521006312	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521006313	Coenzyme A binding pocket [chemical binding]; other site
349521006314	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
349521006315	catalytic site [active]
349521006316	Cupin superfamily protein; Region: Cupin_4; pfam08007
349521006317	Cupin-like domain; Region: Cupin_8; pfam13621
349521006318	adenylosuccinate lyase; Provisional; Region: PRK09285
349521006319	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
349521006320	tetramer interface [polypeptide binding]; other site
349521006321	active site
349521006322	putative lysogenization regulator; Reviewed; Region: PRK00218
349521006323	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
349521006324	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
349521006325	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
349521006326	nudix motif; other site
349521006327	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
349521006328	pseudouridine synthase; Region: TIGR00093
349521006329	active site
349521006330	isocitrate dehydrogenase; Validated; Region: PRK07362
349521006331	isocitrate dehydrogenase; Reviewed; Region: PRK07006
349521006332	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
349521006333	DNA-binding site [nucleotide binding]; DNA binding site
349521006334	RNA-binding motif; other site
349521006335	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
349521006336	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
349521006337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521006338	Walker A motif; other site
349521006339	ATP binding site [chemical binding]; other site
349521006340	Walker B motif; other site
349521006341	arginine finger; other site
349521006342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521006343	Walker A motif; other site
349521006344	ATP binding site [chemical binding]; other site
349521006345	Walker B motif; other site
349521006346	arginine finger; other site
349521006347	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
349521006348	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
349521006349	rRNA binding site [nucleotide binding]; other site
349521006350	predicted 30S ribosome binding site; other site
349521006351	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
349521006352	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
349521006353	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
349521006354	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
349521006355	thioredoxin reductase; Provisional; Region: PRK10262
349521006356	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349521006357	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521006358	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521006359	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349521006360	Walker A motif; other site
349521006361	ATP binding site [chemical binding]; other site
349521006362	Walker B motif; other site
349521006363	arginine finger; other site
349521006364	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
349521006365	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
349521006366	putative active site; other site
349521006367	catalytic triad [active]
349521006368	putative dimer interface [polypeptide binding]; other site
349521006369	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
349521006370	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
349521006371	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
349521006372	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349521006373	FtsX-like permease family; Region: FtsX; pfam02687
349521006374	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
349521006375	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349521006376	Walker A/P-loop; other site
349521006377	ATP binding site [chemical binding]; other site
349521006378	Q-loop/lid; other site
349521006379	ABC transporter signature motif; other site
349521006380	Walker B; other site
349521006381	D-loop; other site
349521006382	H-loop/switch region; other site
349521006383	transaldolase-like protein; Provisional; Region: PTZ00411
349521006384	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
349521006385	active site
349521006386	dimer interface [polypeptide binding]; other site
349521006387	catalytic residue [active]
349521006388	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
349521006389	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
349521006390	FMN binding site [chemical binding]; other site
349521006391	active site
349521006392	catalytic residues [active]
349521006393	substrate binding site [chemical binding]; other site
349521006394	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349521006395	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
349521006396	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
349521006397	nonfunctional nucleotidyltransferase/DNA polymerase due to HC0_02366 insertion; COG0389
349521006398	predicted signal transduction protein containing sensor and EAL domains; COG4943
349521006399	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521006400	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521006401	substrate binding pocket [chemical binding]; other site
349521006402	membrane-bound complex binding site; other site
349521006403	hinge residues; other site
349521006404	Cache domain; Region: Cache_1; pfam02743
349521006405	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521006406	dimerization interface [polypeptide binding]; other site
349521006407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349521006408	PAS fold; Region: PAS_4; pfam08448
349521006409	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521006410	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521006411	metal binding site [ion binding]; metal-binding site
349521006412	active site
349521006413	I-site; other site
349521006414	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
349521006415	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
349521006416	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
349521006417	oligomer interface [polypeptide binding]; other site
349521006418	active site residues [active]
349521006419	Protein of unknown function (DUF3103); Region: DUF3103; pfam11301
349521006420	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
349521006421	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
349521006422	H-NS histone family; Region: Histone_HNS; pfam00816
349521006423	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
349521006424	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
349521006425	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
349521006426	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
349521006427	SLBB domain; Region: SLBB; pfam10531
349521006428	SLBB domain; Region: SLBB; pfam10531
349521006429	SLBB domain; Region: SLBB; pfam10531
349521006430	SLBB domain; Region: SLBB; pfam10531
349521006431	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
349521006432	Chain length determinant protein; Region: Wzz; pfam02706
349521006433	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
349521006434	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
349521006435	dimer interface [polypeptide binding]; other site
349521006436	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
349521006437	active site
349521006438	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
349521006439	Ligand Binding Site [chemical binding]; other site
349521006440	Molecular Tunnel; other site
349521006441	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349521006442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521006443	S-adenosylmethionine binding site [chemical binding]; other site
349521006444	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
349521006445	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
349521006446	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
349521006447	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349521006448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521006449	S-adenosylmethionine binding site [chemical binding]; other site
349521006450	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521006451	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349521006452	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349521006453	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
349521006454	active site
349521006455	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349521006456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521006457	S-adenosylmethionine binding site [chemical binding]; other site
349521006458	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521006459	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521006460	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
349521006461	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
349521006462	active site
349521006463	dimer interface [polypeptide binding]; other site
349521006464	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
349521006465	Ligand Binding Site [chemical binding]; other site
349521006466	Molecular Tunnel; other site
349521006467	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
349521006468	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
349521006469	active site
349521006470	dimer interface [polypeptide binding]; other site
349521006471	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
349521006472	Ligand Binding Site [chemical binding]; other site
349521006473	Molecular Tunnel; other site
349521006474	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
349521006475	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521006476	putative ADP-binding pocket [chemical binding]; other site
349521006477	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
349521006478	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
349521006479	Mg++ binding site [ion binding]; other site
349521006480	putative catalytic motif [active]
349521006481	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349521006482	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521006483	NAD(P) binding site [chemical binding]; other site
349521006484	active site
349521006485	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
349521006486	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
349521006487	dimer interface [polypeptide binding]; other site
349521006488	active site
349521006489	CoA binding pocket [chemical binding]; other site
349521006490	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
349521006491	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
349521006492	Mg++ binding site [ion binding]; other site
349521006493	putative catalytic motif [active]
349521006494	putative substrate binding site [chemical binding]; other site
349521006495	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
349521006496	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
349521006497	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
349521006498	NAD(P) binding site [chemical binding]; other site
349521006499	homodimer interface [polypeptide binding]; other site
349521006500	substrate binding site [chemical binding]; other site
349521006501	active site
349521006502	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
349521006503	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
349521006504	NAD binding site [chemical binding]; other site
349521006505	substrate binding site [chemical binding]; other site
349521006506	homodimer interface [polypeptide binding]; other site
349521006507	active site
349521006508	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
349521006509	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
349521006510	substrate binding site; other site
349521006511	tetramer interface; other site
349521006512	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
349521006513	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
349521006514	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
349521006515	NADP binding site [chemical binding]; other site
349521006516	active site
349521006517	putative substrate binding site [chemical binding]; other site
349521006518	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
349521006519	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349521006520	active site
349521006521	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349521006522	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
349521006523	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
349521006524	Substrate binding site; other site
349521006525	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
349521006526	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
349521006527	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
349521006528	metal binding site [ion binding]; metal-binding site
349521006529	PilZ domain; Region: PilZ; cl01260
349521006530	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
349521006531	active site
349521006532	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521006533	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349521006534	hypothetical protein; Provisional; Region: PRK10279
349521006535	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
349521006536	active site
349521006537	nucleophile elbow; other site
349521006538	HemK family putative methylases; Region: hemK_fam; TIGR00536
349521006539	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521006540	S-adenosylmethionine binding site [chemical binding]; other site
349521006541	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
349521006542	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
349521006543	Tetramer interface [polypeptide binding]; other site
349521006544	active site
349521006545	FMN-binding site [chemical binding]; other site
349521006546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521006547	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
349521006548	putative substrate translocation pore; other site
349521006549	Phasin protein; Region: Phasin_2; cl11491
349521006550	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
349521006551	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
349521006552	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521006553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521006554	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349521006555	dimerization interface [polypeptide binding]; other site
349521006556	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
349521006557	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
349521006558	substrate binding site [chemical binding]; other site
349521006559	ligand binding site [chemical binding]; other site
349521006560	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
349521006561	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
349521006562	substrate binding site [chemical binding]; other site
349521006563	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
349521006564	tartrate dehydrogenase; Region: TTC; TIGR02089
349521006565	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
349521006566	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
349521006567	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
349521006568	FimV N-terminal domain; Region: FimV_core; TIGR03505
349521006569	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
349521006570	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
349521006571	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
349521006572	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
349521006573	dimerization interface 3.5A [polypeptide binding]; other site
349521006574	active site
349521006575	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
349521006576	active site
349521006577	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
349521006578	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
349521006579	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521006580	catalytic residue [active]
349521006581	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
349521006582	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
349521006583	substrate binding site [chemical binding]; other site
349521006584	active site
349521006585	catalytic residues [active]
349521006586	heterodimer interface [polypeptide binding]; other site
349521006587	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
349521006588	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
349521006589	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
349521006590	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349521006591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
349521006592	Sporulation related domain; Region: SPOR; pfam05036
349521006593	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
349521006594	Colicin V production protein; Region: Colicin_V; cl00567
349521006595	amidophosphoribosyltransferase; Provisional; Region: PRK09246
349521006596	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
349521006597	active site
349521006598	tetramer interface [polypeptide binding]; other site
349521006599	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521006600	active site
349521006601	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
349521006602	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
349521006603	homodimer interface [polypeptide binding]; other site
349521006604	substrate-cofactor binding pocket; other site
349521006605	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521006606	catalytic residue [active]
349521006607	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
349521006608	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
349521006609	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
349521006610	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
349521006611	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
349521006612	recombination factor protein RarA; Reviewed; Region: PRK13342
349521006613	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521006614	Walker A motif; other site
349521006615	ATP binding site [chemical binding]; other site
349521006616	Walker B motif; other site
349521006617	arginine finger; other site
349521006618	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
349521006619	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
349521006620	seryl-tRNA synthetase; Provisional; Region: PRK05431
349521006621	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
349521006622	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
349521006623	dimer interface [polypeptide binding]; other site
349521006624	active site
349521006625	motif 1; other site
349521006626	motif 2; other site
349521006627	motif 3; other site
349521006628	siroheme synthase; Provisional; Region: cysG; PRK10637
349521006629	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
349521006630	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
349521006631	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
349521006632	active site
349521006633	SAM binding site [chemical binding]; other site
349521006634	homodimer interface [polypeptide binding]; other site
349521006635	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
349521006636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521006637	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
349521006638	Walker A/P-loop; other site
349521006639	ATP binding site [chemical binding]; other site
349521006640	Q-loop/lid; other site
349521006641	ABC transporter signature motif; other site
349521006642	Walker B; other site
349521006643	D-loop; other site
349521006644	H-loop/switch region; other site
349521006645	TOBE domain; Region: TOBE; pfam03459
349521006646	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
349521006647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521006648	dimer interface [polypeptide binding]; other site
349521006649	conserved gate region; other site
349521006650	putative PBP binding loops; other site
349521006651	ABC-ATPase subunit interface; other site
349521006652	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
349521006653	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
349521006654	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
349521006655	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
349521006656	molybdenum-pterin binding domain; Region: Mop; TIGR00638
349521006657	molybdenum-pterin binding domain; Region: Mop; TIGR00638
349521006658	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
349521006659	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
349521006660	phosphopeptide binding site; other site
349521006661	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
349521006662	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521006663	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521006664	dimer interface [polypeptide binding]; other site
349521006665	putative CheW interface [polypeptide binding]; other site
349521006666	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
349521006667	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
349521006668	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521006669	Zn2+ binding site [ion binding]; other site
349521006670	Mg2+ binding site [ion binding]; other site
349521006671	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521006672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521006673	active site
349521006674	phosphorylation site [posttranslational modification]
349521006675	intermolecular recognition site; other site
349521006676	dimerization interface [polypeptide binding]; other site
349521006677	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521006678	DNA binding site [nucleotide binding]
349521006679	endoglucanase; Region: PLN02308
349521006680	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
349521006681	Cellulose binding domain; Region: CBM_3; smart01067
349521006682	Cellulose binding domain; Region: CBM_2; pfam00553
349521006683	Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011
349521006684	Cellulose binding domain; Region: CBM_2; pfam00553
349521006685	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349521006686	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349521006687	DNA binding site [nucleotide binding]
349521006688	domain linker motif; other site
349521006689	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
349521006690	dimerization interface [polypeptide binding]; other site
349521006691	ligand binding site [chemical binding]; other site
349521006692	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
349521006693	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
349521006694	putative ligand binding site [chemical binding]; other site
349521006695	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
349521006696	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
349521006697	Walker A/P-loop; other site
349521006698	ATP binding site [chemical binding]; other site
349521006699	Q-loop/lid; other site
349521006700	ABC transporter signature motif; other site
349521006701	Walker B; other site
349521006702	D-loop; other site
349521006703	H-loop/switch region; other site
349521006704	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
349521006705	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349521006706	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
349521006707	TM-ABC transporter signature motif; other site
349521006708	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
349521006709	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
349521006710	NAD(P) binding site [chemical binding]; other site
349521006711	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
349521006712	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
349521006713	N- and C-terminal domain interface [polypeptide binding]; other site
349521006714	putative active site [active]
349521006715	MgATP binding site [chemical binding]; other site
349521006716	catalytic site [active]
349521006717	metal binding site [ion binding]; metal-binding site
349521006718	putative xylulose binding site [chemical binding]; other site
349521006719	putative homodimer interface [polypeptide binding]; other site
349521006720	transaldolase-like protein; Provisional; Region: PTZ00411
349521006721	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
349521006722	active site
349521006723	dimer interface [polypeptide binding]; other site
349521006724	catalytic residue [active]
349521006725	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
349521006726	YtkA-like; Region: YtkA; pfam13115
349521006727	choice-of-anchor B domain; Region: choice_anch_B; TIGR04312
349521006728	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
349521006729	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
349521006730	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
349521006731	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
349521006732	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
349521006733	active site
349521006734	Zn binding site [ion binding]; other site
349521006735	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521006736	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
349521006737	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
349521006738	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349521006739	catalytic loop [active]
349521006740	iron binding site [ion binding]; other site
349521006741	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521006742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521006743	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521006744	putative effector binding pocket; other site
349521006745	dimerization interface [polypeptide binding]; other site
349521006746	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521006747	EamA-like transporter family; Region: EamA; cl17759
349521006748	EamA-like transporter family; Region: EamA; pfam00892
349521006749	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521006750	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521006751	putative DNA binding site [nucleotide binding]; other site
349521006752	putative Zn2+ binding site [ion binding]; other site
349521006753	AsnC family; Region: AsnC_trans_reg; pfam01037
349521006754	Restriction endonuclease BamHI; Region: BamHI; pfam02923
349521006755	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
349521006756	DNA methylase; Region: N6_N4_Mtase; pfam01555
349521006757	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
349521006758	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
349521006759	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
349521006760	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
349521006761	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
349521006762	dimer interface [polypeptide binding]; other site
349521006763	FMN binding site [chemical binding]; other site
349521006764	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521006765	TIGR01777 family protein; Region: yfcH
349521006766	NAD(P) binding site [chemical binding]; other site
349521006767	active site
349521006768	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
349521006769	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521006770	substrate binding site [chemical binding]; other site
349521006771	oxyanion hole (OAH) forming residues; other site
349521006772	trimer interface [polypeptide binding]; other site
349521006773	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
349521006774	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
349521006775	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
349521006776	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
349521006777	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
349521006778	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
349521006779	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
349521006780	Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919
349521006781	dimer interface [polypeptide binding]; other site
349521006782	acyl-activating enzyme (AAE) consensus motif; other site
349521006783	putative active site [active]
349521006784	putative AMP binding site [chemical binding]; other site
349521006785	putative CoA binding site [chemical binding]; other site
349521006786	chemical substrate binding site [chemical binding]; other site
349521006787	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
349521006788	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349521006789	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349521006790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521006791	NAD(P) binding site [chemical binding]; other site
349521006792	active site
349521006793	putative chaperone; Provisional; Region: PRK11678
349521006794	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
349521006795	nucleotide binding site [chemical binding]; other site
349521006796	putative NEF/HSP70 interaction site [polypeptide binding]; other site
349521006797	SBD interface [polypeptide binding]; other site
349521006798	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521006799	high affinity sulphate transporter 1; Region: sulP; TIGR00815
349521006800	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
349521006801	Sulfate transporter family; Region: Sulfate_transp; pfam00916
349521006802	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
349521006803	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349521006804	Ligand Binding Site [chemical binding]; other site
349521006805	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349521006806	Ligand Binding Site [chemical binding]; other site
349521006807	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
349521006808	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
349521006809	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
349521006810	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
349521006811	PilZ domain; Region: PilZ; pfam07238
349521006812	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521006813	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
349521006814	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
349521006815	NAD binding site [chemical binding]; other site
349521006816	homotetramer interface [polypeptide binding]; other site
349521006817	homodimer interface [polypeptide binding]; other site
349521006818	substrate binding site [chemical binding]; other site
349521006819	active site
349521006820	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
349521006821	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521006822	Walker A/P-loop; other site
349521006823	ATP binding site [chemical binding]; other site
349521006824	Q-loop/lid; other site
349521006825	ABC transporter signature motif; other site
349521006826	Walker B; other site
349521006827	D-loop; other site
349521006828	H-loop/switch region; other site
349521006829	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
349521006830	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521006831	Walker A/P-loop; other site
349521006832	ATP binding site [chemical binding]; other site
349521006833	Q-loop/lid; other site
349521006834	ABC transporter signature motif; other site
349521006835	Walker B; other site
349521006836	D-loop; other site
349521006837	H-loop/switch region; other site
349521006838	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
349521006839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521006840	dimer interface [polypeptide binding]; other site
349521006841	conserved gate region; other site
349521006842	putative PBP binding loops; other site
349521006843	ABC-ATPase subunit interface; other site
349521006844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521006845	dimer interface [polypeptide binding]; other site
349521006846	conserved gate region; other site
349521006847	putative PBP binding loops; other site
349521006848	ABC-ATPase subunit interface; other site
349521006849	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
349521006850	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
349521006851	HDOD domain; Region: HDOD; pfam08668
349521006852	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
349521006853	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349521006854	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349521006855	catalytic residue [active]
349521006856	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349521006857	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
349521006858	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349521006859	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
349521006860	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349521006861	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
349521006862	Methyltransferase domain; Region: Methyltransf_11; pfam08241
349521006863	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
349521006864	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
349521006865	RNA/DNA hybrid binding site [nucleotide binding]; other site
349521006866	active site
349521006867	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
349521006868	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
349521006869	active site
349521006870	catalytic site [active]
349521006871	substrate binding site [chemical binding]; other site
349521006872	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
349521006873	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
349521006874	SCP-2 sterol transfer family; Region: SCP2; pfam02036
349521006875	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
349521006876	putative inner membrane peptidase; Provisional; Region: PRK11778
349521006877	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
349521006878	tandem repeat interface [polypeptide binding]; other site
349521006879	oligomer interface [polypeptide binding]; other site
349521006880	active site residues [active]
349521006881	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
349521006882	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
349521006883	NADP binding site [chemical binding]; other site
349521006884	dimer interface [polypeptide binding]; other site
349521006885	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
349521006886	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
349521006887	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
349521006888	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
349521006889	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
349521006890	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
349521006891	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
349521006892	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
349521006893	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
349521006894	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
349521006895	substrate binding pocket [chemical binding]; other site
349521006896	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
349521006897	B12 binding site [chemical binding]; other site
349521006898	cobalt ligand [ion binding]; other site
349521006899	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
349521006900	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
349521006901	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
349521006902	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
349521006903	hypothetical protein; Validated; Region: PRK09071
349521006904	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
349521006905	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
349521006906	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
349521006907	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
349521006908	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
349521006909	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
349521006910	YccA-like proteins; Region: YccA_like; cd10433
349521006911	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
349521006912	PilZ domain; Region: PilZ; pfam07238
349521006913	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
349521006914	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
349521006915	active site
349521006916	HIGH motif; other site
349521006917	dimer interface [polypeptide binding]; other site
349521006918	KMSKS motif; other site
349521006919	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
349521006920	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349521006921	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
349521006922	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
349521006923	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
349521006924	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521006925	dimer interface [polypeptide binding]; other site
349521006926	phosphorylation site [posttranslational modification]
349521006927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521006928	ATP binding site [chemical binding]; other site
349521006929	Mg2+ binding site [ion binding]; other site
349521006930	G-X-G motif; other site
349521006931	Cation transport protein; Region: TrkH; cl17365
349521006932	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
349521006933	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
349521006934	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521006935	dimerization interface [polypeptide binding]; other site
349521006936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521006937	dimer interface [polypeptide binding]; other site
349521006938	phosphorylation site [posttranslational modification]
349521006939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521006940	ATP binding site [chemical binding]; other site
349521006941	Mg2+ binding site [ion binding]; other site
349521006942	G-X-G motif; other site
349521006943	Response regulator receiver domain; Region: Response_reg; pfam00072
349521006944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521006945	active site
349521006946	phosphorylation site [posttranslational modification]
349521006947	intermolecular recognition site; other site
349521006948	dimerization interface [polypeptide binding]; other site
349521006949	Response regulator receiver domain; Region: Response_reg; pfam00072
349521006950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521006951	active site
349521006952	phosphorylation site [posttranslational modification]
349521006953	intermolecular recognition site; other site
349521006954	dimerization interface [polypeptide binding]; other site
349521006955	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521006956	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521006957	metal binding site [ion binding]; metal-binding site
349521006958	active site
349521006959	I-site; other site
349521006960	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521006961	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
349521006962	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521006963	N-terminal plug; other site
349521006964	ligand-binding site [chemical binding]; other site
349521006965	short chain dehydrogenase; Provisional; Region: PRK06172
349521006966	classical (c) SDRs; Region: SDR_c; cd05233
349521006967	NAD(P) binding site [chemical binding]; other site
349521006968	active site
349521006969	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
349521006970	citrylCoA binding site [chemical binding]; other site
349521006971	oxalacetate binding site [chemical binding]; other site
349521006972	coenzyme A binding site [chemical binding]; other site
349521006973	catalytic triad [active]
349521006974	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
349521006975	active site
349521006976	oxalacetate binding site [chemical binding]; other site
349521006977	citrylCoA binding site [chemical binding]; other site
349521006978	coenzyme A binding site [chemical binding]; other site
349521006979	catalytic triad [active]
349521006980	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
349521006981	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349521006982	PYR/PP interface [polypeptide binding]; other site
349521006983	dimer interface [polypeptide binding]; other site
349521006984	TPP binding site [chemical binding]; other site
349521006985	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349521006986	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
349521006987	TPP-binding site [chemical binding]; other site
349521006988	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521006989	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521006990	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521006991	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521006992	substrate binding pocket [chemical binding]; other site
349521006993	membrane-bound complex binding site; other site
349521006994	hinge residues; other site
349521006995	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
349521006996	HD domain; Region: HD_4; pfam13328
349521006997	Integrase core domain; Region: rve_3; pfam13683
349521006998	Integrase core domain; Region: rve; pfam00665
349521006999	Transposase; Region: HTH_Tnp_1; cl17663
349521007000	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
349521007001	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
349521007002	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
349521007003	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
349521007004	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
349521007005	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
349521007006	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
349521007007	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
349521007008	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
349521007009	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521007010	dimerization interface [polypeptide binding]; other site
349521007011	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521007012	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521007013	dimer interface [polypeptide binding]; other site
349521007014	putative CheW interface [polypeptide binding]; other site
349521007015	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
349521007016	ApbE family; Region: ApbE; pfam02424
349521007017	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
349521007018	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
349521007019	Bacterial SH3 domain; Region: SH3_3; pfam08239
349521007020	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
349521007021	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
349521007022	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
349521007023	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349521007024	catalytic residues [active]
349521007025	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
349521007026	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
349521007027	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521007028	TPR motif; other site
349521007029	binding surface
349521007030	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521007031	binding surface
349521007032	TPR motif; other site
349521007033	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
349521007034	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521007035	TPR motif; other site
349521007036	binding surface
349521007037	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
349521007038	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
349521007039	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521007040	binding surface
349521007041	TPR motif; other site
349521007042	TPR repeat; Region: TPR_11; pfam13414
349521007043	Transglycosylase SLT domain; Region: SLT_2; pfam13406
349521007044	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349521007045	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349521007046	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
349521007047	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
349521007048	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
349521007049	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349521007050	RNA binding surface [nucleotide binding]; other site
349521007051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521007052	S-adenosylmethionine binding site [chemical binding]; other site
349521007053	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521007054	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349521007055	Coenzyme A binding pocket [chemical binding]; other site
349521007056	Peptidase_C39 like family; Region: DUF3335; pfam11814
349521007057	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
349521007058	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
349521007059	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349521007060	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
349521007061	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521007062	Walker A motif; other site
349521007063	ATP binding site [chemical binding]; other site
349521007064	Walker B motif; other site
349521007065	arginine finger; other site
349521007066	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
349521007067	hypothetical protein; Validated; Region: PRK00153
349521007068	recombination protein RecR; Reviewed; Region: recR; PRK00076
349521007069	RecR protein; Region: RecR; pfam02132
349521007070	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
349521007071	putative active site [active]
349521007072	putative metal-binding site [ion binding]; other site
349521007073	tetramer interface [polypeptide binding]; other site
349521007074	ribonuclease D; Region: rnd; TIGR01388
349521007075	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
349521007076	catalytic site [active]
349521007077	putative active site [active]
349521007078	putative substrate binding site [chemical binding]; other site
349521007079	HRDC domain; Region: HRDC; pfam00570
349521007080	YcgL domain; Region: YcgL; pfam05166
349521007081	hypothetical protein; Provisional; Region: PRK05170
349521007082	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
349521007083	metal ion-dependent adhesion site (MIDAS); other site
349521007084	TIGR03503 family protein; Region: TIGR03503
349521007085	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
349521007086	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
349521007087	putative active site [active]
349521007088	putative dimer interface [polypeptide binding]; other site
349521007089	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
349521007090	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
349521007091	dimer interface [polypeptide binding]; other site
349521007092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521007093	catalytic residue [active]
349521007094	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349521007095	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521007096	Walker A motif; other site
349521007097	ATP binding site [chemical binding]; other site
349521007098	Walker B motif; other site
349521007099	arginine finger; other site
349521007100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
349521007101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521007102	binding surface
349521007103	TPR motif; other site
349521007104	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521007105	TPR motif; other site
349521007106	binding surface
349521007107	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
349521007108	Tetratricopeptide repeat; Region: TPR_12; pfam13424
349521007109	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521007110	binding surface
349521007111	TPR motif; other site
349521007112	TPR repeat; Region: TPR_11; pfam13414
349521007113	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
349521007114	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
349521007115	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
349521007116	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
349521007117	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
349521007118	Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066
349521007119	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
349521007120	dimer interaction site [polypeptide binding]; other site
349521007121	substrate-binding tunnel; other site
349521007122	active site
349521007123	catalytic site [active]
349521007124	substrate binding site [chemical binding]; other site
349521007125	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
349521007126	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349521007127	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677
349521007128	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
349521007129	acyl-activating enzyme (AAE) consensus motif; other site
349521007130	putative AMP binding site [chemical binding]; other site
349521007131	putative active site [active]
349521007132	putative CoA binding site [chemical binding]; other site
349521007133	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
349521007134	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521007135	ATP binding site [chemical binding]; other site
349521007136	putative Mg++ binding site [ion binding]; other site
349521007137	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521007138	nucleotide binding region [chemical binding]; other site
349521007139	ATP-binding site [chemical binding]; other site
349521007140	Helicase associated domain (HA2); Region: HA2; pfam04408
349521007141	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
349521007142	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
349521007143	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
349521007144	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
349521007145	dimer interface [polypeptide binding]; other site
349521007146	active site
349521007147	CoA binding pocket [chemical binding]; other site
349521007148	VacJ like lipoprotein; Region: VacJ; cl01073
349521007149	Domain of unknown function (DUF3336); Region: DUF3336; pfam11815
349521007150	Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206
349521007151	active site
349521007152	nucleophile elbow; other site
349521007153	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
349521007154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521007155	Walker A motif; other site
349521007156	ATP binding site [chemical binding]; other site
349521007157	Walker B motif; other site
349521007158	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
349521007159	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
349521007160	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
349521007161	AAA ATPase domain; Region: AAA_16; pfam13191
349521007162	AAA domain; Region: AAA_22; pfam13401
349521007163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521007164	binding surface
349521007165	TPR motif; other site
349521007166	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349521007167	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521007168	DNA binding residues [nucleotide binding]
349521007169	dimerization interface [polypeptide binding]; other site
349521007170	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349521007171	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
349521007172	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521007173	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
349521007174	substrate binding site [chemical binding]; other site
349521007175	dimerization interface [polypeptide binding]; other site
349521007176	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
349521007177	Active Sites [active]
349521007178	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
349521007179	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521007180	motif II; other site
349521007181	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
349521007182	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
349521007183	chorismate binding enzyme; Region: Chorismate_bind; cl10555
349521007184	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
349521007185	Domain of unknown function (DUF3784); Region: DUF3784; pfam12650
349521007186	Protein of unknown function DUF58; Region: DUF58; pfam01882
349521007187	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
349521007188	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
349521007189	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
349521007190	DNA polymerase III subunit delta'; Validated; Region: PRK05707
349521007191	DNA polymerase III subunit delta'; Validated; Region: PRK08485
349521007192	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
349521007193	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
349521007194	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
349521007195	Lumazine binding domain; Region: Lum_binding; pfam00677
349521007196	Lumazine binding domain; Region: Lum_binding; pfam00677
349521007197	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
349521007198	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521007199	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521007200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
349521007201	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349521007202	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
349521007203	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
349521007204	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
349521007205	Mechanosensitive ion channel; Region: MS_channel; pfam00924
349521007206	5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136
349521007207	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
349521007208	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
349521007209	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
349521007210	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521007211	ATP binding site [chemical binding]; other site
349521007212	putative Mg++ binding site [ion binding]; other site
349521007213	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521007214	nucleotide binding region [chemical binding]; other site
349521007215	ATP-binding site [chemical binding]; other site
349521007216	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
349521007217	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
349521007218	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
349521007219	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
349521007220	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
349521007221	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349521007222	E3 interaction surface; other site
349521007223	lipoyl attachment site [posttranslational modification]; other site
349521007224	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
349521007225	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
349521007226	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
349521007227	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
349521007228	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
349521007229	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
349521007230	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
349521007231	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
349521007232	FAD binding pocket [chemical binding]; other site
349521007233	FAD binding motif [chemical binding]; other site
349521007234	phosphate binding motif [ion binding]; other site
349521007235	beta-alpha-beta structure motif; other site
349521007236	NAD binding pocket [chemical binding]; other site
349521007237	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
349521007238	ApbE family; Region: ApbE; pfam02424
349521007239	Protein of unknown function (DUF539); Region: DUF539; cl01129
349521007240	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
349521007241	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349521007242	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521007243	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349521007244	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
349521007245	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
349521007246	active site
349521007247	catalytic site [active]
349521007248	metal binding site [ion binding]; metal-binding site
349521007249	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
349521007250	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
349521007251	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
349521007252	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
349521007253	Competence protein; Region: Competence; pfam03772
349521007254	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
349521007255	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
349521007256	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
349521007257	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
349521007258	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
349521007259	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
349521007260	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521007261	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
349521007262	Walker A/P-loop; other site
349521007263	ATP binding site [chemical binding]; other site
349521007264	Q-loop/lid; other site
349521007265	ABC transporter signature motif; other site
349521007266	Walker B; other site
349521007267	D-loop; other site
349521007268	H-loop/switch region; other site
349521007269	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
349521007270	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
349521007271	Uncharacterized conserved protein [Function unknown]; Region: COG2835
349521007272	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
349521007273	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
349521007274	Ligand binding site; other site
349521007275	oligomer interface; other site
349521007276	Low molecular weight phosphatase family; Region: LMWPc; cd00115
349521007277	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
349521007278	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
349521007279	FAD binding domain; Region: FAD_binding_4; pfam01565
349521007280	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
349521007281	Transcriptional regulators [Transcription]; Region: GntR; COG1802
349521007282	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521007283	DNA-binding site [nucleotide binding]; DNA binding site
349521007284	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
349521007285	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
349521007286	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
349521007287	tetramer interface [polypeptide binding]; other site
349521007288	active site
349521007289	Mg2+/Mn2+ binding site [ion binding]; other site
349521007290	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
349521007291	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
349521007292	dimer interface [polypeptide binding]; other site
349521007293	active site
349521007294	citrylCoA binding site [chemical binding]; other site
349521007295	oxalacetate/citrate binding site [chemical binding]; other site
349521007296	coenzyme A binding site [chemical binding]; other site
349521007297	catalytic triad [active]
349521007298	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
349521007299	2-methylcitrate dehydratase; Region: prpD; TIGR02330
349521007300	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
349521007301	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
349521007302	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
349521007303	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
349521007304	Bacterial sugar transferase; Region: Bac_transf; pfam02397
349521007305	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
349521007306	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
349521007307	SLBB domain; Region: SLBB; pfam10531
349521007308	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
349521007309	Chain length determinant protein; Region: Wzz; cl15801
349521007310	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
349521007311	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
349521007312	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
349521007313	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
349521007314	putative active site [active]
349521007315	putative catalytic site [active]
349521007316	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
349521007317	FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019
349521007318	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521007319	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521007320	acyl-activating enzyme (AAE) consensus motif; other site
349521007321	active site
349521007322	AMP binding site [chemical binding]; other site
349521007323	CoA binding site [chemical binding]; other site
349521007324	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007325	Condensation domain; Region: Condensation; pfam00668
349521007326	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521007327	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
349521007328	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007329	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
349521007330	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521007331	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521007332	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
349521007333	Low molecular weight phosphatase family; Region: LMWPc; cl00105
349521007334	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
349521007335	active site
349521007336	O-Antigen ligase; Region: Wzy_C; cl04850
349521007337	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521007338	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521007339	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
349521007340	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
349521007341	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
349521007342	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
349521007343	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
349521007344	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
349521007345	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
349521007346	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521007347	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521007348	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
349521007349	acyl-activating enzyme (AAE) consensus motif; other site
349521007350	AMP binding site [chemical binding]; other site
349521007351	active site
349521007352	CoA binding site [chemical binding]; other site
349521007353	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
349521007354	trimer interface [polypeptide binding]; other site
349521007355	active site
349521007356	substrate binding site [chemical binding]; other site
349521007357	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
349521007358	CoA binding site [chemical binding]; other site
349521007359	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
349521007360	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521007361	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521007362	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
349521007363	ligand-binding site [chemical binding]; other site
349521007364	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521007365	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521007366	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
349521007367	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
349521007368	putative active site [active]
349521007369	exosortase A; Region: exosortase_1; TIGR03109
349521007370	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
349521007371	EpsI family protein; Region: EpsI_fam; TIGR02914
349521007372	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
349521007373	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
349521007374	TrkA-C domain; Region: TrkA_C; pfam02080
349521007375	TrkA-C domain; Region: TrkA_C; pfam02080
349521007376	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
349521007377	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
349521007378	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
349521007379	DXD motif; other site
349521007380	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349521007381	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
349521007382	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521007383	catalytic residue [active]
349521007384	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
349521007385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521007386	binding surface
349521007387	TPR motif; other site
349521007388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521007389	TPR motif; other site
349521007390	binding surface
349521007391	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521007392	binding surface
349521007393	TPR motif; other site
349521007394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521007395	TPR motif; other site
349521007396	binding surface
349521007397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521007398	binding surface
349521007399	TPR motif; other site
349521007400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521007401	TPR motif; other site
349521007402	binding surface
349521007403	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
349521007404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521007405	active site
349521007406	phosphorylation site [posttranslational modification]
349521007407	intermolecular recognition site; other site
349521007408	dimerization interface [polypeptide binding]; other site
349521007409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521007410	Walker A motif; other site
349521007411	ATP binding site [chemical binding]; other site
349521007412	Walker B motif; other site
349521007413	arginine finger; other site
349521007414	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521007415	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
349521007416	GAF domain; Region: GAF_3; pfam13492
349521007417	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521007418	ATP binding site [chemical binding]; other site
349521007419	Mg2+ binding site [ion binding]; other site
349521007420	G-X-G motif; other site
349521007421	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
349521007422	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
349521007423	putative NAD(P) binding site [chemical binding]; other site
349521007424	active site
349521007425	putative substrate binding site [chemical binding]; other site
349521007426	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
349521007427	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349521007428	putative acyl-acceptor binding pocket; other site
349521007429	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
349521007430	Ion transport protein; Region: Ion_trans; pfam00520
349521007431	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
349521007432	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521007433	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521007434	Bacterial transcriptional repressor; Region: TetR; pfam13972
349521007435	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
349521007436	putative catalytic site [active]
349521007437	putative phosphate binding site [ion binding]; other site
349521007438	active site
349521007439	metal binding site A [ion binding]; metal-binding site
349521007440	DNA binding site [nucleotide binding]
349521007441	putative AP binding site [nucleotide binding]; other site
349521007442	putative metal binding site B [ion binding]; other site
349521007443	Protein of unknown function (DUF523); Region: DUF523; pfam04463
349521007444	Uncharacterized conserved protein [Function unknown]; Region: COG3272
349521007445	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
349521007446	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
349521007447	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
349521007448	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521007449	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521007450	active site
349521007451	phosphorylation site [posttranslational modification]
349521007452	intermolecular recognition site; other site
349521007453	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
349521007454	dimerization interface [polypeptide binding]; other site
349521007455	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
349521007456	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349521007457	anti sigma factor interaction site; other site
349521007458	regulatory phosphorylation site [posttranslational modification]; other site
349521007459	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
349521007460	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
349521007461	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
349521007462	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349521007463	catalytic core [active]
349521007464	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
349521007465	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349521007466	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521007467	catalytic residue [active]
349521007468	FOG: CBS domain [General function prediction only]; Region: COG0517
349521007469	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
349521007470	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
349521007471	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
349521007472	dimerization interface [polypeptide binding]; other site
349521007473	cation transport regulator; Reviewed; Region: chaB; PRK09582
349521007474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
349521007475	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
349521007476	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349521007477	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
349521007478	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
349521007479	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
349521007480	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
349521007481	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349521007482	Interdomain contacts; other site
349521007483	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521007484	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521007485	RHS Repeat; Region: RHS_repeat; cl11982
349521007486	RHS Repeat; Region: RHS_repeat; pfam05593
349521007487	RHS Repeat; Region: RHS_repeat; pfam05593
349521007488	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
349521007489	RHS protein; Region: RHS; pfam03527
349521007490	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521007491	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
349521007492	HAMP domain; Region: HAMP; pfam00672
349521007493	dimerization interface [polypeptide binding]; other site
349521007494	PAS fold; Region: PAS_4; pfam08448
349521007495	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521007496	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521007497	metal binding site [ion binding]; metal-binding site
349521007498	active site
349521007499	I-site; other site
349521007500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521007501	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349521007502	Walker A motif; other site
349521007503	ATP binding site [chemical binding]; other site
349521007504	Walker B motif; other site
349521007505	arginine finger; other site
349521007506	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
349521007507	active site
349521007508	Protein kinase domain; Region: Pkinase; pfam00069
349521007509	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521007510	active site
349521007511	ATP binding site [chemical binding]; other site
349521007512	substrate binding site [chemical binding]; other site
349521007513	activation loop (A-loop); other site
349521007514	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
349521007515	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
349521007516	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
349521007517	Active site serine [active]
349521007518	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521007519	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521007520	homodimer interface [polypeptide binding]; other site
349521007521	catalytic residue [active]
349521007522	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
349521007523	active site
349521007524	dimer interface [polypeptide binding]; other site
349521007525	motif 1; other site
349521007526	motif 2; other site
349521007527	motif 3; other site
349521007528	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
349521007529	anticodon binding site; other site
349521007530	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
349521007531	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
349521007532	Ca binding site [ion binding]; other site
349521007533	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
349521007534	putative DNA binding site [nucleotide binding]; other site
349521007535	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
349521007536	putative Zn2+ binding site [ion binding]; other site
349521007537	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521007538	AsnC family; Region: AsnC_trans_reg; pfam01037
349521007539	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521007540	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
349521007541	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521007542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521007543	homodimer interface [polypeptide binding]; other site
349521007544	catalytic residue [active]
349521007545	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
349521007546	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
349521007547	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
349521007548	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521007549	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521007550	substrate binding pocket [chemical binding]; other site
349521007551	membrane-bound complex binding site; other site
349521007552	hinge residues; other site
349521007553	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
349521007554	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
349521007555	SPFH domain / Band 7 family; Region: Band_7; pfam01145
349521007556	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521007557	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
349521007558	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
349521007559	Walker A/P-loop; other site
349521007560	ATP binding site [chemical binding]; other site
349521007561	Q-loop/lid; other site
349521007562	ABC transporter signature motif; other site
349521007563	Walker B; other site
349521007564	D-loop; other site
349521007565	H-loop/switch region; other site
349521007566	Cupin-like domain; Region: Cupin_8; pfam13621
349521007567	Cupin-like domain; Region: Cupin_8; pfam13621
349521007568	Cupin domain; Region: Cupin_2; cl17218
349521007569	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
349521007570	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
349521007571	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
349521007572	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
349521007573	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
349521007574	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
349521007575	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
349521007576	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
349521007577	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689
349521007578	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
349521007579	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
349521007580	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
349521007581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521007582	S-adenosylmethionine binding site [chemical binding]; other site
349521007583	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
349521007584	substrate binding site [chemical binding]; other site
349521007585	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
349521007586	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349521007587	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
349521007588	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
349521007589	Chromate transporter; Region: Chromate_transp; pfam02417
349521007590	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521007591	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349521007592	Winged helix-turn helix; Region: HTH_29; pfam13551
349521007593	Homeodomain-like domain; Region: HTH_32; pfam13565
349521007594	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
349521007595	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521007596	N-terminal plug; other site
349521007597	ligand-binding site [chemical binding]; other site
349521007598	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349521007599	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
349521007600	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
349521007601	active site
349521007602	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521007603	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
349521007604	acyl-activating enzyme (AAE) consensus motif; other site
349521007605	AMP binding site [chemical binding]; other site
349521007606	active site
349521007607	CoA binding site [chemical binding]; other site
349521007608	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
349521007609	CoA-transferase family III; Region: CoA_transf_3; pfam02515
349521007610	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
349521007611	CoA-transferase family III; Region: CoA_transf_3; pfam02515
349521007612	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
349521007613	MoaE interaction surface [polypeptide binding]; other site
349521007614	MoeB interaction surface [polypeptide binding]; other site
349521007615	thiocarboxylated glycine; other site
349521007616	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
349521007617	MPN+ (JAMM) motif; other site
349521007618	Zinc-binding site [ion binding]; other site
349521007619	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
349521007620	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
349521007621	ATP binding site [chemical binding]; other site
349521007622	substrate interface [chemical binding]; other site
349521007623	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349521007624	active site residue [active]
349521007625	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349521007626	active site
349521007627	DNA binding site [nucleotide binding]
349521007628	Int/Topo IB signature motif; other site
349521007629	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
349521007630	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
349521007631	cofactor binding site; other site
349521007632	DNA binding site [nucleotide binding]
349521007633	substrate interaction site [chemical binding]; other site
349521007634	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
349521007635	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
349521007636	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
349521007637	active site
349521007638	catalytic site [active]
349521007639	substrate binding site [chemical binding]; other site
349521007640	Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065
349521007641	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
349521007642	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
349521007643	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521007644	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521007645	non-specific DNA binding site [nucleotide binding]; other site
349521007646	salt bridge; other site
349521007647	sequence-specific DNA binding site [nucleotide binding]; other site
349521007648	Response regulator receiver domain; Region: Response_reg; pfam00072
349521007649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521007650	active site
349521007651	phosphorylation site [posttranslational modification]
349521007652	intermolecular recognition site; other site
349521007653	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
349521007654	Catalytic site [active]
349521007655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
349521007656	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
349521007657	active site
349521007658	metal binding site [ion binding]; metal-binding site
349521007659	interdomain interaction site; other site
349521007660	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
349521007661	CDC6, C terminal; Region: Cdc6_C; pfam09079
349521007662	DNA binding site [nucleotide binding]
349521007663	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
349521007664	amidase catalytic site [active]
349521007665	Zn binding residues [ion binding]; other site
349521007666	substrate binding site [chemical binding]; other site
349521007667	Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720
349521007668	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
349521007669	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
349521007670	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
349521007671	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
349521007672	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
349521007673	tandem repeat interface [polypeptide binding]; other site
349521007674	oligomer interface [polypeptide binding]; other site
349521007675	active site residues [active]
349521007676	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
349521007677	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
349521007678	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
349521007679	Enterocin A Immunity; Region: EntA_Immun; pfam08951
349521007680	MAEBL; Provisional; Region: PTZ00121
349521007681	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
349521007682	Uncharacterized conserved protein [Function unknown]; Region: COG1284
349521007683	Yip1 domain; Region: Yip1; pfam04893
349521007684	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
349521007685	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
349521007686	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
349521007687	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315
349521007688	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349521007689	putative ligand binding site [chemical binding]; other site
349521007690	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521007691	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521007692	substrate binding pocket [chemical binding]; other site
349521007693	membrane-bound complex binding site; other site
349521007694	hinge residues; other site
349521007695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521007696	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521007697	putative substrate translocation pore; other site
349521007698	Helix-turn-helix domain; Region: HTH_18; pfam12833
349521007699	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521007700	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521007701	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521007702	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
349521007703	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
349521007704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
349521007705	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
349521007706	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
349521007707	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521007708	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521007709	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
349521007710	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521007711	ABC-ATPase subunit  interface; other site
349521007712	dimer interface [polypeptide binding]; other site
349521007713	putative PBP binding regions; other site
349521007714	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
349521007715	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521007716	Walker A/P-loop; other site
349521007717	ATP binding site [chemical binding]; other site
349521007718	Q-loop/lid; other site
349521007719	ABC transporter signature motif; other site
349521007720	Walker B; other site
349521007721	D-loop; other site
349521007722	H-loop/switch region; other site
349521007723	ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531
349521007724	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
349521007725	metal binding site [ion binding]; metal-binding site
349521007726	Periplasmic binding protein TroA_c.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145
349521007727	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
349521007728	putative ligand binding site [chemical binding]; other site
349521007729	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
349521007730	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
349521007731	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
349521007732	metal binding site 2 [ion binding]; metal-binding site
349521007733	putative DNA binding helix; other site
349521007734	metal binding site 1 [ion binding]; metal-binding site
349521007735	dimer interface [polypeptide binding]; other site
349521007736	structural Zn2+ binding site [ion binding]; other site
349521007737	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
349521007738	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
349521007739	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521007740	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521007741	acyl-activating enzyme (AAE) consensus motif; other site
349521007742	AMP binding site [chemical binding]; other site
349521007743	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007744	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
349521007745	B12 binding domain; Region: B12-binding; pfam02310
349521007746	B12 binding site [chemical binding]; other site
349521007747	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521007748	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
349521007749	FeS/SAM binding site; other site
349521007750	Condensation domain; Region: Condensation; pfam00668
349521007751	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521007752	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
349521007753	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
349521007754	acyl-activating enzyme (AAE) consensus motif; other site
349521007755	AMP binding site [chemical binding]; other site
349521007756	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007757	Condensation domain; Region: Condensation; pfam00668
349521007758	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521007759	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
349521007760	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521007761	acyl-activating enzyme (AAE) consensus motif; other site
349521007762	AMP binding site [chemical binding]; other site
349521007763	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007764	Condensation domain; Region: Condensation; pfam00668
349521007765	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521007766	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
349521007767	Condensation domain; Region: Condensation; pfam00668
349521007768	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521007769	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521007770	acyl-activating enzyme (AAE) consensus motif; other site
349521007771	AMP binding site [chemical binding]; other site
349521007772	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007773	Condensation domain; Region: Condensation; pfam00668
349521007774	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521007775	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521007776	acyl-activating enzyme (AAE) consensus motif; other site
349521007777	AMP binding site [chemical binding]; other site
349521007778	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007779	Condensation domain; Region: Condensation; pfam00668
349521007780	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
349521007781	Condensation domain; Region: Condensation; pfam00668
349521007782	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521007783	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
349521007784	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521007785	acyl-activating enzyme (AAE) consensus motif; other site
349521007786	AMP binding site [chemical binding]; other site
349521007787	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007788	Condensation domain; Region: Condensation; pfam00668
349521007789	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
349521007790	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
349521007791	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521007792	active site
349521007793	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
349521007794	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521007795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521007796	S-adenosylmethionine binding site [chemical binding]; other site
349521007797	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
349521007798	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521007799	NAD(P) binding site [chemical binding]; other site
349521007800	active site
349521007801	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007802	Condensation domain; Region: Condensation; pfam00668
349521007803	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521007804	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
349521007805	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521007806	acyl-activating enzyme (AAE) consensus motif; other site
349521007807	AMP binding site [chemical binding]; other site
349521007808	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007809	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
349521007810	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521007811	active site
349521007812	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
349521007813	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
349521007814	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
349521007815	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
349521007816	putative NADP binding site [chemical binding]; other site
349521007817	active site
349521007818	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007819	acyl-CoA synthetase; Validated; Region: PRK05850
349521007820	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
349521007821	acyl-activating enzyme (AAE) consensus motif; other site
349521007822	active site
349521007823	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
349521007824	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
349521007825	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521007826	active site
349521007827	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
349521007828	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
349521007829	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521007830	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
349521007831	NAD(P) binding site [chemical binding]; other site
349521007832	active site
349521007833	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
349521007834	Condensation domain; Region: Condensation; pfam00668
349521007835	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521007836	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
349521007837	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521007838	acyl-activating enzyme (AAE) consensus motif; other site
349521007839	AMP binding site [chemical binding]; other site
349521007840	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521007841	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
349521007842	Protein of unknown function, DUF481; Region: DUF481; cl01213
349521007843	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521007844	PAS domain; Region: PAS_9; pfam13426
349521007845	putative active site [active]
349521007846	heme pocket [chemical binding]; other site
349521007847	GAF domain; Region: GAF; pfam01590
349521007848	GAF domain; Region: GAF_2; pfam13185
349521007849	PAS domain S-box; Region: sensory_box; TIGR00229
349521007850	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521007851	putative active site [active]
349521007852	heme pocket [chemical binding]; other site
349521007853	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521007854	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521007855	metal binding site [ion binding]; metal-binding site
349521007856	active site
349521007857	I-site; other site
349521007858	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
349521007859	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
349521007860	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521007861	catalytic residue [active]
349521007862	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521007863	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
349521007864	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521007865	dimerization interface [polypeptide binding]; other site
349521007866	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521007867	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
349521007868	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
349521007869	catalytic triad [active]
349521007870	putative active site [active]
349521007871	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
349521007872	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
349521007873	Predicted membrane protein [Function unknown]; Region: COG4539
349521007874	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
349521007875	active site
349521007876	catalytic residues [active]
349521007877	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
349521007878	putative metal binding site [ion binding]; other site
349521007879	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
349521007880	putative metal binding site [ion binding]; other site
349521007881	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
349521007882	putative catalytic site [active]
349521007883	putative metal binding site [ion binding]; other site
349521007884	putative phosphate binding site [ion binding]; other site
349521007885	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521007886	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
349521007887	putative C-terminal domain interface [polypeptide binding]; other site
349521007888	putative GSH binding site (G-site) [chemical binding]; other site
349521007889	putative dimer interface [polypeptide binding]; other site
349521007890	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
349521007891	N-terminal domain interface [polypeptide binding]; other site
349521007892	dimer interface [polypeptide binding]; other site
349521007893	substrate binding pocket (H-site) [chemical binding]; other site
349521007894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521007895	binding surface
349521007896	TPR motif; other site
349521007897	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349521007898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521007899	S-adenosylmethionine binding site [chemical binding]; other site
349521007900	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
349521007901	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
349521007902	Helix-turn-helix domain; Region: HTH_18; pfam12833
349521007903	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521007904	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
349521007905	active site
349521007906	replicative DNA helicase; Provisional; Region: PRK05973
349521007907	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
349521007908	Serine hydrolase; Region: Ser_hydrolase; pfam06821
349521007909	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521007910	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
349521007911	active site
349521007912	catalytic tetrad [active]
349521007913	Helix-turn-helix domain; Region: HTH_18; pfam12833
349521007914	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521007915	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
349521007916	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349521007917	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349521007918	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
349521007919	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
349521007920	putative substrate binding pocket [chemical binding]; other site
349521007921	trimer interface [polypeptide binding]; other site
349521007922	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
349521007923	Peptidase family M28; Region: Peptidase_M28; pfam04389
349521007924	active site
349521007925	metal binding site [ion binding]; metal-binding site
349521007926	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521007927	Outer membrane efflux protein; Region: OEP; pfam02321
349521007928	Outer membrane efflux protein; Region: OEP; pfam02321
349521007929	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
349521007930	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521007931	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
349521007932	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
349521007933	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
349521007934	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
349521007935	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349521007936	CGGC domain; Region: CGGC; cl02356
349521007937	Uncharacterized conserved protein [Function unknown]; Region: COG1262
349521007938	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
349521007939	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
349521007940	nudix motif; other site
349521007941	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
349521007942	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
349521007943	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
349521007944	active site
349521007945	Uncharacterized conserved protein [Function unknown]; Region: COG3391
349521007946	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
349521007947	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
349521007948	cleavage site
349521007949	active site
349521007950	substrate binding sites [chemical binding]; other site
349521007951	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521007952	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
349521007953	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
349521007954	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349521007955	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521007956	ligand binding site [chemical binding]; other site
349521007957	flexible hinge region; other site
349521007958	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349521007959	non-specific DNA interactions [nucleotide binding]; other site
349521007960	DNA binding site [nucleotide binding]
349521007961	sequence specific DNA binding site [nucleotide binding]; other site
349521007962	putative cAMP binding site [chemical binding]; other site
349521007963	Protein of unknown function (DUF461); Region: DUF461; pfam04314
349521007964	Cadherin repeat-like domain; Region: CA_like; cl15786
349521007965	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521007966	Ca2+ binding site [ion binding]; other site
349521007967	Peptidase M60-like family; Region: M60-like; pfam13402
349521007968	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
349521007969	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
349521007970	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
349521007971	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
349521007972	DNA binding residues [nucleotide binding]
349521007973	drug binding residues [chemical binding]; other site
349521007974	dimer interface [polypeptide binding]; other site
349521007975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
349521007976	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
349521007977	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
349521007978	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
349521007979	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
349521007980	ligand binding site [chemical binding]; other site
349521007981	homodimer interface [polypeptide binding]; other site
349521007982	NAD(P) binding site [chemical binding]; other site
349521007983	trimer interface B [polypeptide binding]; other site
349521007984	trimer interface A [polypeptide binding]; other site
349521007985	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
349521007986	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
349521007987	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521007988	active site
349521007989	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
349521007990	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521007991	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349521007992	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349521007993	Cupin; Region: Cupin_6; pfam12852
349521007994	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521007995	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521007996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521007997	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521007998	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521007999	substrate binding pocket [chemical binding]; other site
349521008000	membrane-bound complex binding site; other site
349521008001	hinge residues; other site
349521008002	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349521008003	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521008004	NAD(P) binding site [chemical binding]; other site
349521008005	active site
349521008006	Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919
349521008007	putative active site [active]
349521008008	redox center [active]
349521008009	intracellular protease, PfpI family; Region: PfpI; TIGR01382
349521008010	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
349521008011	proposed catalytic triad [active]
349521008012	conserved cys residue [active]
349521008013	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521008014	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521008015	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521008016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521008017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521008018	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521008019	putative effector binding pocket; other site
349521008020	dimerization interface [polypeptide binding]; other site
349521008021	SnoaL-like domain; Region: SnoaL_3; pfam13474
349521008022	SnoaL-like domain; Region: SnoaL_2; pfam12680
349521008023	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
349521008024	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521008025	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
349521008026	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521008027	motif II; other site
349521008028	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
349521008029	sugar binding site [chemical binding]; other site
349521008030	Beta/Gamma crystallin; Region: Crystall; cl02528
349521008031	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
349521008032	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
349521008033	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
349521008034	oligomer interface [polypeptide binding]; other site
349521008035	Cl binding site [ion binding]; other site
349521008036	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
349521008037	intersubunit interface [polypeptide binding]; other site
349521008038	active site
349521008039	catalytic residue [active]
349521008040	phosphopentomutase; Provisional; Region: PRK05362
349521008041	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
349521008042	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
349521008043	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
349521008044	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
349521008045	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521008046	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521008047	dimerization interface [polypeptide binding]; other site
349521008048	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349521008049	catalytic core [active]
349521008050	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
349521008051	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
349521008052	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
349521008053	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
349521008054	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
349521008055	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
349521008056	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
349521008057	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
349521008058	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
349521008059	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521008060	catalytic residue [active]
349521008061	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
349521008062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521008063	dimer interface [polypeptide binding]; other site
349521008064	conserved gate region; other site
349521008065	putative PBP binding loops; other site
349521008066	ABC-ATPase subunit interface; other site
349521008067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521008068	dimer interface [polypeptide binding]; other site
349521008069	conserved gate region; other site
349521008070	putative PBP binding loops; other site
349521008071	ABC-ATPase subunit interface; other site
349521008072	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
349521008073	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521008074	Walker A/P-loop; other site
349521008075	ATP binding site [chemical binding]; other site
349521008076	Q-loop/lid; other site
349521008077	ABC transporter signature motif; other site
349521008078	Walker B; other site
349521008079	D-loop; other site
349521008080	H-loop/switch region; other site
349521008081	TOBE domain; Region: TOBE_2; pfam08402
349521008082	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
349521008083	putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261
349521008084	transcriptional regulator protein; Region: phnR; TIGR03337
349521008085	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521008086	DNA-binding site [nucleotide binding]; DNA binding site
349521008087	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
349521008088	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
349521008089	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
349521008090	active site
349521008091	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
349521008092	Ca binding site [ion binding]; other site
349521008093	ligand binding site I [chemical binding]; other site
349521008094	homodimer interface [polypeptide binding]; other site
349521008095	ligand binding site II [chemical binding]; other site
349521008096	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
349521008097	Int/Topo IB signature motif; other site
349521008098	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
349521008099	N- and C-terminal domain interface [polypeptide binding]; other site
349521008100	D-xylulose kinase; Region: XylB; TIGR01312
349521008101	active site
349521008102	MgATP binding site [chemical binding]; other site
349521008103	catalytic site [active]
349521008104	metal binding site [ion binding]; metal-binding site
349521008105	xylulose binding site [chemical binding]; other site
349521008106	putative homodimer interface [polypeptide binding]; other site
349521008107	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
349521008108	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521008109	putative active site [active]
349521008110	heme pocket [chemical binding]; other site
349521008111	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521008112	putative active site [active]
349521008113	heme pocket [chemical binding]; other site
349521008114	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521008115	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521008116	dimer interface [polypeptide binding]; other site
349521008117	putative CheW interface [polypeptide binding]; other site
349521008118	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
349521008119	nudix motif; other site
349521008120	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
349521008121	sugar binding site [chemical binding]; other site
349521008122	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
349521008123	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
349521008124	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
349521008125	putative acetyltransferase; Provisional; Region: PRK03624
349521008126	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521008127	Coenzyme A binding pocket [chemical binding]; other site
349521008128	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
349521008129	protein binding surface [polypeptide binding]; other site
349521008130	HEAT repeats; Region: HEAT_2; pfam13646
349521008131	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521008132	PAS fold; Region: PAS_3; pfam08447
349521008133	putative active site [active]
349521008134	heme pocket [chemical binding]; other site
349521008135	HAMP domain; Region: HAMP; pfam00672
349521008136	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521008137	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521008138	dimer interface [polypeptide binding]; other site
349521008139	putative CheW interface [polypeptide binding]; other site
349521008140	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
349521008141	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521008142	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521008143	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521008144	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
349521008145	membrane-bound complex binding site; other site
349521008146	hinge residues; other site
349521008147	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521008148	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521008149	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
349521008150	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521008151	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521008152	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
349521008153	substrate binding pocket [chemical binding]; other site
349521008154	dimerization interface [polypeptide binding]; other site
349521008155	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
349521008156	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
349521008157	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
349521008158	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
349521008159	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
349521008160	active site
349521008161	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
349521008162	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521008163	Walker A/P-loop; other site
349521008164	ATP binding site [chemical binding]; other site
349521008165	Q-loop/lid; other site
349521008166	ABC transporter signature motif; other site
349521008167	Walker B; other site
349521008168	D-loop; other site
349521008169	H-loop/switch region; other site
349521008170	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349521008171	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
349521008172	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521008173	Walker A/P-loop; other site
349521008174	ATP binding site [chemical binding]; other site
349521008175	Q-loop/lid; other site
349521008176	ABC transporter signature motif; other site
349521008177	Walker B; other site
349521008178	D-loop; other site
349521008179	H-loop/switch region; other site
349521008180	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349521008181	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
349521008182	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
349521008183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521008184	dimer interface [polypeptide binding]; other site
349521008185	conserved gate region; other site
349521008186	putative PBP binding loops; other site
349521008187	ABC-ATPase subunit interface; other site
349521008188	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
349521008189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521008190	dimer interface [polypeptide binding]; other site
349521008191	conserved gate region; other site
349521008192	putative PBP binding loops; other site
349521008193	ABC-ATPase subunit interface; other site
349521008194	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
349521008195	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
349521008196	peptide binding site [polypeptide binding]; other site
349521008197	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349521008198	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521008199	Walker A motif; other site
349521008200	ATP binding site [chemical binding]; other site
349521008201	Walker B motif; other site
349521008202	arginine finger; other site
349521008203	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
349521008204	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
349521008205	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
349521008206	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521008207	catalytic residue [active]
349521008208	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
349521008209	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
349521008210	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
349521008211	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
349521008212	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
349521008213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349521008214	Leucine rich repeat; Region: LRR_8; pfam13855
349521008215	Leucine rich repeat; Region: LRR_8; pfam13855
349521008216	Leucine rich repeat; Region: LRR_8; pfam13855
349521008217	Leucine rich repeat; Region: LRR_8; pfam13855
349521008218	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
349521008219	Fatty acid desaturase; Region: FA_desaturase; pfam00487
349521008220	Di-iron ligands [ion binding]; other site
349521008221	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349521008222	anti sigma factor interaction site; other site
349521008223	regulatory phosphorylation site [posttranslational modification]; other site
349521008224	HAMP domain; Region: HAMP; pfam00672
349521008225	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521008226	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521008227	metal binding site [ion binding]; metal-binding site
349521008228	active site
349521008229	I-site; other site
349521008230	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
349521008231	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
349521008232	homodimer interface [polypeptide binding]; other site
349521008233	active site
349521008234	SAM binding site [chemical binding]; other site
349521008235	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
349521008236	Uncharacterized conserved protein [Function unknown]; Region: COG3791
349521008237	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
349521008238	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
349521008239	NAD(P) binding site [chemical binding]; other site
349521008240	catalytic residues [active]
349521008241	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
349521008242	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
349521008243	inhibitor site; inhibition site
349521008244	active site
349521008245	dimer interface [polypeptide binding]; other site
349521008246	catalytic residue [active]
349521008247	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
349521008248	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
349521008249	putative sugar binding sites [chemical binding]; other site
349521008250	Q-X-W motif; other site
349521008251	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
349521008252	Pectate lyase; Region: Pec_lyase_C; cl01593
349521008253	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
349521008254	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
349521008255	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349521008256	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
349521008257	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
349521008258	Transcriptional regulators [Transcription]; Region: GntR; COG1802
349521008259	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521008260	DNA-binding site [nucleotide binding]; DNA binding site
349521008261	FCD domain; Region: FCD; pfam07729
349521008262	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521008263	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521008264	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521008265	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521008266	DNA binding site [nucleotide binding]
349521008267	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
349521008268	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
349521008269	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
349521008270	active site
349521008271	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521008272	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521008273	active site
349521008274	ATP binding site [chemical binding]; other site
349521008275	substrate binding site [chemical binding]; other site
349521008276	activation loop (A-loop); other site
349521008277	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
349521008278	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
349521008279	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521008280	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521008281	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
349521008282	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
349521008283	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521008284	catalytic residue [active]
349521008285	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
349521008286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521008287	Walker A/P-loop; other site
349521008288	ATP binding site [chemical binding]; other site
349521008289	Q-loop/lid; other site
349521008290	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521008291	ABC transporter signature motif; other site
349521008292	Walker B; other site
349521008293	D-loop; other site
349521008294	ABC transporter; Region: ABC_tran_2; pfam12848
349521008295	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521008296	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
349521008297	Phage Tail Collar Domain; Region: Collar; pfam07484
349521008298	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
349521008299	Phage Tail Collar Domain; Region: Collar; pfam07484
349521008300	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
349521008301	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
349521008302	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
349521008303	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
349521008304	Bacterial Ig-like domain; Region: Big_5; pfam13205
349521008305	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521008306	Integrase core domain; Region: rve_2; pfam13333
349521008307	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521008308	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521008309	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521008310	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521008311	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
349521008312	N-terminal domain interface [polypeptide binding]; other site
349521008313	dimer interface [polypeptide binding]; other site
349521008314	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
349521008315	N-terminal domain interface [polypeptide binding]; other site
349521008316	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521008317	dimerization interface [polypeptide binding]; other site
349521008318	putative DNA binding site [nucleotide binding]; other site
349521008319	Transcriptional regulators [Transcription]; Region: MarR; COG1846
349521008320	putative Zn2+ binding site [ion binding]; other site
349521008321	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
349521008322	putative hydrophobic ligand binding site [chemical binding]; other site
349521008323	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
349521008324	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
349521008325	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
349521008326	dimer interface [polypeptide binding]; other site
349521008327	active site
349521008328	heme binding site [chemical binding]; other site
349521008329	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
349521008330	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
349521008331	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
349521008332	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
349521008333	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
349521008334	multidrug resistance protein MdtN; Provisional; Region: PRK10476
349521008335	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521008336	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521008337	transcriptional regulator SlyA; Provisional; Region: PRK03573
349521008338	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
349521008339	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
349521008340	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
349521008341	Part of AAA domain; Region: AAA_19; pfam13245
349521008342	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
349521008343	AAA domain; Region: AAA_12; pfam13087
349521008344	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
349521008345	putative active site [active]
349521008346	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
349521008347	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415
349521008348	Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of...; Region: HX; cl02471
349521008349	Metal binding sites [ion binding]; metal-binding site
349521008350	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
349521008351	Anti-sigma-K factor rskA; Region: RskA; pfam10099
349521008352	RNA polymerase sigma factor; Provisional; Region: PRK12514
349521008353	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349521008354	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
349521008355	DNA binding residues [nucleotide binding]
349521008356	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
349521008357	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
349521008358	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
349521008359	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521008360	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521008361	YCII-related domain; Region: YCII; cl00999
349521008362	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
349521008363	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521008364	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521008365	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521008366	dimerization interface [polypeptide binding]; other site
349521008367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521008368	S-adenosylmethionine binding site [chemical binding]; other site
349521008369	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
349521008370	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349521008371	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349521008372	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349521008373	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
349521008374	type III secretion system protein SsaD; Provisional; Region: PRK15367
349521008375	Type III secretion needle MxiH like; Region: MxiH; pfam09392
349521008376	Type III secretion needle MxiH like; Region: MxiH; pfam09392
349521008377	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
349521008378	YOP proteins translocation protein K (YscK); Region: YscK; pfam06578
349521008379	Flagellar assembly protein FliH; Region: FliH; pfam02108
349521008380	RHS Repeat; Region: RHS_repeat; pfam05593
349521008381	RHS Repeat; Region: RHS_repeat; pfam05593
349521008382	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521008383	RHS Repeat; Region: RHS_repeat; pfam05593
349521008384	RHS Repeat; Region: RHS_repeat; pfam05593
349521008385	RHS Repeat; Region: RHS_repeat; cl11982
349521008386	RHS Repeat; Region: RHS_repeat; pfam05593
349521008387	RHS Repeat; Region: RHS_repeat; pfam05593
349521008388	RHS protein; Region: RHS; pfam03527
349521008389	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521008390	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521008391	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521008392	Homeodomain-like domain; Region: HTH_23; pfam13384
349521008393	Winged helix-turn helix; Region: HTH_29; pfam13551
349521008394	Winged helix-turn helix; Region: HTH_33; pfam13592
349521008395	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521008396	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349521008397	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
349521008398	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
349521008399	type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401
349521008400	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
349521008401	type III secretion system protein YscR; Provisional; Region: PRK12797
349521008402	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
349521008403	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
349521008404	Type III secretion protein YscO; Region: YscO; pfam07321
349521008405	type III secretion system ATPase; Provisional; Region: PRK06936
349521008406	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349521008407	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
349521008408	Walker A motif/ATP binding site; other site
349521008409	Walker B motif; other site
349521008410	AAA domain; Region: AAA_21; pfam13304
349521008411	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
349521008412	Cupin domain; Region: Cupin_2; cl17218
349521008413	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
349521008414	FHIPEP family; Region: FHIPEP; pfam00771
349521008415	TPR repeat; Region: TPR_11; pfam13414
349521008416	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521008417	binding surface
349521008418	TPR motif; other site
349521008419	type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503
349521008420	HrpJ-like domain; Region: HrpJ; pfam07201
349521008421	TyeA; Region: TyeA; cl07611
349521008422	Secretion system effector C (SseC) like family; Region: SseC; pfam04888
349521008423	Secretion system effector C (SseC) like family; Region: SseC; pfam04888
349521008424	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
349521008425	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349521008426	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521008427	DNA binding residues [nucleotide binding]
349521008428	dimerization interface [polypeptide binding]; other site
349521008429	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349521008430	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521008431	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521008432	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349521008433	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349521008434	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349521008435	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349521008436	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349521008437	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521008438	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
349521008439	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521008440	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521008441	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521008442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521008443	putative PBP binding loops; other site
349521008444	ABC-ATPase subunit interface; other site
349521008445	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349521008446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521008447	dimer interface [polypeptide binding]; other site
349521008448	conserved gate region; other site
349521008449	putative PBP binding loops; other site
349521008450	ABC-ATPase subunit interface; other site
349521008451	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
349521008452	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349521008453	Walker A/P-loop; other site
349521008454	ATP binding site [chemical binding]; other site
349521008455	Q-loop/lid; other site
349521008456	ABC transporter signature motif; other site
349521008457	Walker B; other site
349521008458	D-loop; other site
349521008459	H-loop/switch region; other site
349521008460	TOBE domain; Region: TOBE_2; pfam08402
349521008461	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
349521008462	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349521008463	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
349521008464	active site
349521008465	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349521008466	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349521008467	DNA binding site [nucleotide binding]
349521008468	domain linker motif; other site
349521008469	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
349521008470	putative dimerization interface [polypeptide binding]; other site
349521008471	putative ligand binding site [chemical binding]; other site
349521008472	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
349521008473	active site
349521008474	catalytic site [active]
349521008475	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
349521008476	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
349521008477	putative sugar binding sites [chemical binding]; other site
349521008478	Q-X-W motif; other site
349521008479	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349521008480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521008481	binding surface
349521008482	TPR motif; other site
349521008483	TPR repeat; Region: TPR_11; pfam13414
349521008484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521008485	TPR motif; other site
349521008486	binding surface
349521008487	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521008488	TPR repeat; Region: TPR_11; pfam13414
349521008489	TPR motif; other site
349521008490	binding surface
349521008491	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521008492	binding surface
349521008493	TPR motif; other site
349521008494	TPR repeat; Region: TPR_11; pfam13414
349521008495	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349521008496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521008497	binding surface
349521008498	TPR motif; other site
349521008499	von Willebrand factor type A domain; Region: VWA_2; pfam13519
349521008500	metal ion-dependent adhesion site (MIDAS); other site
349521008501	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
349521008502	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
349521008503	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
349521008504	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
349521008505	FAD binding pocket [chemical binding]; other site
349521008506	FAD binding motif [chemical binding]; other site
349521008507	phosphate binding motif [ion binding]; other site
349521008508	NAD binding pocket [chemical binding]; other site
349521008509	Transcriptional regulators [Transcription]; Region: MarR; COG1846
349521008510	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
349521008511	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521008512	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
349521008513	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
349521008514	metal ion-dependent adhesion site (MIDAS); other site
349521008515	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349521008516	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
349521008517	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
349521008518	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
349521008519	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
349521008520	Uncharacterized conserved protein [Function unknown]; Region: COG3791
349521008521	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521008522	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521008523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521008524	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
349521008525	putative effector binding pocket; other site
349521008526	putative dimerization interface [polypeptide binding]; other site
349521008527	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521008528	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
349521008529	putative C-terminal domain interface [polypeptide binding]; other site
349521008530	putative GSH binding site (G-site) [chemical binding]; other site
349521008531	putative dimer interface [polypeptide binding]; other site
349521008532	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
349521008533	putative N-terminal domain interface [polypeptide binding]; other site
349521008534	putative dimer interface [polypeptide binding]; other site
349521008535	putative substrate binding pocket (H-site) [chemical binding]; other site
349521008536	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
349521008537	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
349521008538	H-NS histone family; Region: Histone_HNS; pfam00816
349521008539	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
349521008540	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521008541	DNA-binding site [nucleotide binding]; DNA binding site
349521008542	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521008543	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521008544	homodimer interface [polypeptide binding]; other site
349521008545	catalytic residue [active]
349521008546	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
349521008547	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349521008548	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
349521008549	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349521008550	catalytic residues [active]
349521008551	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349521008552	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
349521008553	catalytic residues [active]
349521008554	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
349521008555	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
349521008556	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
349521008557	Chromate transporter; Region: Chromate_transp; pfam02417
349521008558	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
349521008559	DsbD alpha interface [polypeptide binding]; other site
349521008560	catalytic residues [active]
349521008561	Cupin; Region: Cupin_6; pfam12852
349521008562	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521008563	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521008564	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521008565	hypothetical protein; Provisional; Region: PRK02237
349521008566	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521008567	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521008568	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
349521008569	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
349521008570	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521008571	NAD(P) binding site [chemical binding]; other site
349521008572	active site
349521008573	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
349521008574	LytTr DNA-binding domain; Region: LytTR; smart00850
349521008575	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521008576	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521008577	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521008578	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521008579	putative effector binding pocket; other site
349521008580	dimerization interface [polypeptide binding]; other site
349521008581	BON domain; Region: BON; pfam04972
349521008582	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
349521008583	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
349521008584	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
349521008585	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
349521008586	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
349521008587	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
349521008588	flagellar motor switch protein; Reviewed; Region: PRK06782
349521008589	HAMP domain; Region: HAMP; pfam00672
349521008590	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521008591	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521008592	metal binding site [ion binding]; metal-binding site
349521008593	active site
349521008594	I-site; other site
349521008595	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
349521008596	NapD protein; Region: NapD; pfam03927
349521008597	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
349521008598	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
349521008599	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
349521008600	[4Fe-4S] binding site [ion binding]; other site
349521008601	molybdopterin cofactor binding site; other site
349521008602	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
349521008603	molybdopterin cofactor binding site; other site
349521008604	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
349521008605	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
349521008606	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
349521008607	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
349521008608	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521008609	dimerization interface [polypeptide binding]; other site
349521008610	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521008611	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521008612	dimer interface [polypeptide binding]; other site
349521008613	putative CheW interface [polypeptide binding]; other site
349521008614	cyclase homology domain; Region: CHD; cd07302
349521008615	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
349521008616	nucleotidyl binding site; other site
349521008617	metal binding site [ion binding]; metal-binding site
349521008618	dimer interface [polypeptide binding]; other site
349521008619	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
349521008620	phosphopeptide binding site; other site
349521008621	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
349521008622	haemagglutination activity domain; Region: Haemagg_act; pfam05860
349521008623	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
349521008624	Calx-beta domain; Region: Calx-beta; cl02522
349521008625	Tetratricopeptide repeat; Region: TPR_12; pfam13424
349521008626	Tetratricopeptide repeat; Region: TPR_12; pfam13424
349521008627	CHAT domain; Region: CHAT; cl17868
349521008628	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
349521008629	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
349521008630	Surface antigen; Region: Bac_surface_Ag; pfam01103
349521008631	Caspase domain; Region: Peptidase_C14; pfam00656
349521008632	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
349521008633	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
349521008634	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
349521008635	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
349521008636	NosL; Region: NosL; pfam05573
349521008637	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
349521008638	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
349521008639	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
349521008640	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349521008641	Walker A/P-loop; other site
349521008642	ATP binding site [chemical binding]; other site
349521008643	Q-loop/lid; other site
349521008644	ABC transporter signature motif; other site
349521008645	Walker B; other site
349521008646	D-loop; other site
349521008647	H-loop/switch region; other site
349521008648	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
349521008649	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
349521008650	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
349521008651	nitrous-oxide reductase; Validated; Region: PRK02888
349521008652	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
349521008653	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
349521008654	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
349521008655	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
349521008656	4Fe-4S binding domain; Region: Fer4_5; pfam12801
349521008657	LabA_like proteins; Region: LabA; cd10911
349521008658	Uncharacterized conserved protein [Function unknown]; Region: COG1432
349521008659	putative metal binding site [ion binding]; other site
349521008660	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
349521008661	RNA binding site [nucleotide binding]; other site
349521008662	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
349521008663	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
349521008664	Polyphenol oxidase middle domain; Region: PPO1_DWL; pfam12142
349521008665	Predicted transcriptional regulators [Transcription]; Region: COG1733
349521008666	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
349521008667	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521008668	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
349521008669	dimer interface [polypeptide binding]; other site
349521008670	NLI interacting factor-like phosphatase; Region: NIF; cl17354
349521008671	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
349521008672	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521008673	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521008674	Kelch domain; Region: Kelch; smart00612
349521008675	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
349521008676	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
349521008677	active site
349521008678	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
349521008679	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
349521008680	DNA binding residues [nucleotide binding]
349521008681	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
349521008682	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349521008683	acetyl-CoA acetyltransferase; Provisional; Region: PRK08170
349521008684	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349521008685	dimer interface [polypeptide binding]; other site
349521008686	active site
349521008687	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
349521008688	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521008689	substrate binding site [chemical binding]; other site
349521008690	oxyanion hole (OAH) forming residues; other site
349521008691	trimer interface [polypeptide binding]; other site
349521008692	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
349521008693	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349521008694	Rhomboid family; Region: Rhomboid; pfam01694
349521008695	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
349521008696	Bacterial sugar transferase; Region: Bac_transf; pfam02397
349521008697	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
349521008698	active site
349521008699	catalytic triad [active]
349521008700	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349521008701	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521008702	Walker A motif; other site
349521008703	ATP binding site [chemical binding]; other site
349521008704	Walker B motif; other site
349521008705	arginine finger; other site
349521008706	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101
349521008707	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
349521008708	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521008709	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521008710	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
349521008711	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
349521008712	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
349521008713	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521008714	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
349521008715	EpsI family protein; Region: EpsI_fam; TIGR02914
349521008716	exosortase B; Region: exosortase_2; TIGR03113
349521008717	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
349521008718	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
349521008719	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349521008720	chain length determinant protein EpsF; Region: EpsF; TIGR03017
349521008721	Chain length determinant protein; Region: Wzz; cl15801
349521008722	Chain length determinant protein; Region: Wzz; cl15801
349521008723	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
349521008724	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
349521008725	SLBB domain; Region: SLBB; pfam10531
349521008726	SLBB domain; Region: SLBB; pfam10531
349521008727	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
349521008728	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
349521008729	exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014
349521008730	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
349521008731	sulfotransferase; Region: PLN02164
349521008732	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
349521008733	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
349521008734	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
349521008735	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
349521008736	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349521008737	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
349521008738	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
349521008739	Cupin-like domain; Region: Cupin_8; pfam13621
349521008740	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521008741	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
349521008742	active site
349521008743	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
349521008744	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
349521008745	putative NADP binding site [chemical binding]; other site
349521008746	active site
349521008747	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008748	Condensation domain; Region: Condensation; pfam00668
349521008749	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521008750	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
349521008751	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521008752	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521008753	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521008754	acyl-activating enzyme (AAE) consensus motif; other site
349521008755	acyl-activating enzyme (AAE) consensus motif; other site
349521008756	AMP binding site [chemical binding]; other site
349521008757	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008758	Condensation domain; Region: Condensation; pfam00668
349521008759	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521008760	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521008761	acyl-activating enzyme (AAE) consensus motif; other site
349521008762	AMP binding site [chemical binding]; other site
349521008763	active site
349521008764	CoA binding site [chemical binding]; other site
349521008765	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008766	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521008767	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521008768	acyl-activating enzyme (AAE) consensus motif; other site
349521008769	AMP binding site [chemical binding]; other site
349521008770	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008771	Condensation domain; Region: Condensation; pfam00668
349521008772	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521008773	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521008774	acyl-activating enzyme (AAE) consensus motif; other site
349521008775	AMP binding site [chemical binding]; other site
349521008776	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008777	Condensation domain; Region: Condensation; pfam00668
349521008778	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
349521008779	Beta-lactamase; Region: Beta-lactamase; pfam00144
349521008780	ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615
349521008781	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
349521008782	Walker A/P-loop; other site
349521008783	ATP binding site [chemical binding]; other site
349521008784	Q-loop/lid; other site
349521008785	ABC transporter signature motif; other site
349521008786	Walker B; other site
349521008787	D-loop; other site
349521008788	H-loop/switch region; other site
349521008789	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521008790	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
349521008791	active site
349521008792	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
349521008793	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
349521008794	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
349521008795	NADP binding site [chemical binding]; other site
349521008796	active site
349521008797	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
349521008798	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
349521008799	Enoylreductase; Region: PKS_ER; smart00829
349521008800	NAD(P) binding site [chemical binding]; other site
349521008801	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008802	Condensation domain; Region: Condensation; pfam00668
349521008803	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521008804	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521008805	acyl-activating enzyme (AAE) consensus motif; other site
349521008806	AMP binding site [chemical binding]; other site
349521008807	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008808	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
349521008809	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
349521008810	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521008811	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521008812	acyl-activating enzyme (AAE) consensus motif; other site
349521008813	AMP binding site [chemical binding]; other site
349521008814	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521008815	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521008816	acyl-activating enzyme (AAE) consensus motif; other site
349521008817	AMP binding site [chemical binding]; other site
349521008818	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349521008819	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521008820	active site
349521008821	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008822	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
349521008823	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
349521008824	siderophore binding site; other site
349521008825	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
349521008826	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521008827	ABC-ATPase subunit  interface; other site
349521008828	dimer interface [polypeptide binding]; other site
349521008829	putative PBP binding regions; other site
349521008830	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
349521008831	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521008832	ABC-ATPase subunit  interface; other site
349521008833	dimer interface [polypeptide binding]; other site
349521008834	putative PBP binding regions; other site
349521008835	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
349521008836	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
349521008837	Walker A/P-loop; other site
349521008838	ATP binding site [chemical binding]; other site
349521008839	Q-loop/lid; other site
349521008840	ABC transporter signature motif; other site
349521008841	Walker B; other site
349521008842	D-loop; other site
349521008843	H-loop/switch region; other site
349521008844	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
349521008845	putative dimer interface [polypeptide binding]; other site
349521008846	putative [2Fe-2S] cluster binding site [ion binding]; other site
349521008847	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
349521008848	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521008849	N-terminal plug; other site
349521008850	ligand-binding site [chemical binding]; other site
349521008851	XdhC Rossmann domain; Region: XdhC_C; pfam13478
349521008852	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
349521008853	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
349521008854	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521008855	dimerization interface [polypeptide binding]; other site
349521008856	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521008857	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521008858	dimer interface [polypeptide binding]; other site
349521008859	putative CheW interface [polypeptide binding]; other site
349521008860	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
349521008861	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521008862	ATP binding site [chemical binding]; other site
349521008863	putative Mg++ binding site [ion binding]; other site
349521008864	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521008865	nucleotide binding region [chemical binding]; other site
349521008866	ATP-binding site [chemical binding]; other site
349521008867	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
349521008868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349521008869	PglZ domain; Region: PglZ; pfam08665
349521008870	primosomal protein DnaI; Reviewed; Region: PRK08939
349521008871	Predicted ATPase [General function prediction only]; Region: COG4637
349521008872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521008873	Walker A/P-loop; other site
349521008874	ATP binding site [chemical binding]; other site
349521008875	Nuclease-related domain; Region: NERD; pfam08378
349521008876	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
349521008877	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521008878	active site
349521008879	ATP binding site [chemical binding]; other site
349521008880	substrate binding site [chemical binding]; other site
349521008881	activation loop (A-loop); other site
349521008882	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521008883	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521008884	active site
349521008885	ATP binding site [chemical binding]; other site
349521008886	substrate binding site [chemical binding]; other site
349521008887	activation loop (A-loop); other site
349521008888	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
349521008889	Helix-turn-helix domain; Region: HTH_17; pfam12728
349521008890	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521008891	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521008892	substrate binding pocket [chemical binding]; other site
349521008893	membrane-bound complex binding site; other site
349521008894	hinge residues; other site
349521008895	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
349521008896	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521008897	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521008898	substrate binding pocket [chemical binding]; other site
349521008899	membrane-bound complex binding site; other site
349521008900	hinge residues; other site
349521008901	Right handed beta helix region; Region: Beta_helix; pfam13229
349521008902	Family description; Region: VCBS; pfam13517
349521008903	G8 domain; Region: G8; pfam10162
349521008904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521008905	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521008906	putative substrate translocation pore; other site
349521008907	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008908	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521008909	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
349521008910	active site
349521008911	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521008912	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
349521008913	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
349521008914	putative NADP binding site [chemical binding]; other site
349521008915	active site
349521008916	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521008917	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
349521008918	active site
349521008919	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
349521008920	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
349521008921	putative NADP binding site [chemical binding]; other site
349521008922	active site
349521008923	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
349521008924	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
349521008925	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521008926	active site
349521008927	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
349521008928	catalytic triad [active]
349521008929	dimer interface [polypeptide binding]; other site
349521008930	conserved cis-peptide bond; other site
349521008931	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
349521008932	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349521008933	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
349521008934	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
349521008935	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
349521008936	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
349521008937	putative NADP binding site [chemical binding]; other site
349521008938	active site
349521008939	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349521008940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521008941	S-adenosylmethionine binding site [chemical binding]; other site
349521008942	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
349521008943	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
349521008944	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521008945	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
349521008946	active site
349521008947	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
349521008948	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521008949	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521008950	acyl-activating enzyme (AAE) consensus motif; other site
349521008951	AMP binding site [chemical binding]; other site
349521008952	active site
349521008953	CoA binding site [chemical binding]; other site
349521008954	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521008955	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521008956	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
349521008957	active site
349521008958	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
349521008959	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
349521008960	putative NAD(P) binding site [chemical binding]; other site
349521008961	Predicted transcriptional regulators [Transcription]; Region: COG1733
349521008962	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
349521008963	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
349521008964	potassium/proton antiporter; Reviewed; Region: PRK05326
349521008965	Transporter associated domain; Region: CorC_HlyC; smart01091
349521008966	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349521008967	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521008968	catalytic residue [active]
349521008969	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521008970	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521008971	I-site; other site
349521008972	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
349521008973	nudix motif; other site
349521008974	PAS domain S-box; Region: sensory_box; TIGR00229
349521008975	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521008976	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521008977	metal binding site [ion binding]; metal-binding site
349521008978	active site
349521008979	I-site; other site
349521008980	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
349521008981	active site
349521008982	Leucine rich repeat; Region: LRR_8; pfam13855
349521008983	Leucine rich repeat; Region: LRR_8; pfam13855
349521008984	Leucine rich repeat; Region: LRR_8; pfam13855
349521008985	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
349521008986	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521008987	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521008988	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521008989	putative effector binding pocket; other site
349521008990	dimerization interface [polypeptide binding]; other site
349521008991	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521008992	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
349521008993	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521008994	multidrug efflux protein; Reviewed; Region: PRK09579
349521008995	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891
349521008996	P-class dimer interface [polypeptide binding]; other site
349521008997	Cu2+ binding site [ion binding]; other site
349521008998	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521008999	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521009000	substrate binding pocket [chemical binding]; other site
349521009001	membrane-bound complex binding site; other site
349521009002	hinge residues; other site
349521009003	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521009004	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521009005	substrate binding pocket [chemical binding]; other site
349521009006	membrane-bound complex binding site; other site
349521009007	hinge residues; other site
349521009008	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
349521009009	4Fe-4S binding domain; Region: Fer4_5; pfam12801
349521009010	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
349521009011	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
349521009012	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521009013	DNA-binding site [nucleotide binding]; DNA binding site
349521009014	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521009015	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521009016	homodimer interface [polypeptide binding]; other site
349521009017	catalytic residue [active]
349521009018	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
349521009019	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349521009020	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
349521009021	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
349521009022	FMN binding site [chemical binding]; other site
349521009023	active site
349521009024	substrate binding site [chemical binding]; other site
349521009025	catalytic residue [active]
349521009026	Predicted transcriptional regulator [Transcription]; Region: COG1959
349521009027	Transcriptional regulator; Region: Rrf2; pfam02082
349521009028	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
349521009029	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
349521009030	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
349521009031	RHS Repeat; Region: RHS_repeat; pfam05593
349521009032	RHS Repeat; Region: RHS_repeat; pfam05593
349521009033	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521009034	RHS Repeat; Region: RHS_repeat; cl11982
349521009035	RHS Repeat; Region: RHS_repeat; pfam05593
349521009036	RHS Repeat; Region: RHS_repeat; pfam05593
349521009037	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521009038	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521009039	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521009040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521009041	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
349521009042	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
349521009043	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
349521009044	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521009045	DNA binding residues [nucleotide binding]
349521009046	dimerization interface [polypeptide binding]; other site
349521009047	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
349521009048	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
349521009049	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
349521009050	DctM-like transporters; Region: DctM; pfam06808
349521009051	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
349521009052	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
349521009053	ATP-binding site [chemical binding]; other site
349521009054	Gluconate-6-phosphate binding site [chemical binding]; other site
349521009055	Shikimate kinase; Region: SKI; pfam01202
349521009056	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
349521009057	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349521009058	DNA binding site [nucleotide binding]
349521009059	domain linker motif; other site
349521009060	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
349521009061	putative ligand binding site [chemical binding]; other site
349521009062	putative dimerization interface [polypeptide binding]; other site
349521009063	Uncharacterized conserved protein [Function unknown]; Region: COG1479
349521009064	Protein of unknown function DUF262; Region: DUF262; pfam03235
349521009065	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
349521009066	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
349521009067	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
349521009068	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
349521009069	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
349521009070	DsbD alpha interface [polypeptide binding]; other site
349521009071	catalytic residues [active]
349521009072	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
349521009073	putative catalytic residue [active]
349521009074	Aerolysin toxin; Region: Aerolysin; smart00999
349521009075	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521009076	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521009077	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349521009078	BNR repeat-like domain; Region: BNR_2; pfam13088
349521009079	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
349521009080	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521009081	N-terminal plug; other site
349521009082	ligand-binding site [chemical binding]; other site
349521009083	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521009084	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521009085	substrate binding pocket [chemical binding]; other site
349521009086	membrane-bound complex binding site; other site
349521009087	hinge residues; other site
349521009088	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
349521009089	active site
349521009090	putative substrate binding region [chemical binding]; other site
349521009091	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
349521009092	GIY-YIG motif/motif A; other site
349521009093	putative active site [active]
349521009094	putative metal binding site [ion binding]; other site
349521009095	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
349521009096	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
349521009097	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
349521009098	MarR family; Region: MarR_2; cl17246
349521009099	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
349521009100	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
349521009101	dimer interface [polypeptide binding]; other site
349521009102	FMN binding site [chemical binding]; other site
349521009103	PAS domain S-box; Region: sensory_box; TIGR00229
349521009104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521009105	putative active site [active]
349521009106	heme pocket [chemical binding]; other site
349521009107	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521009108	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349521009109	putative active site [active]
349521009110	heme pocket [chemical binding]; other site
349521009111	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521009112	dimer interface [polypeptide binding]; other site
349521009113	phosphorylation site [posttranslational modification]
349521009114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521009115	ATP binding site [chemical binding]; other site
349521009116	Mg2+ binding site [ion binding]; other site
349521009117	G-X-G motif; other site
349521009118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009119	active site
349521009120	phosphorylation site [posttranslational modification]
349521009121	intermolecular recognition site; other site
349521009122	cheY-homologous receiver domain; Region: REC; smart00448
349521009123	active site
349521009124	phosphorylation site [posttranslational modification]
349521009125	intermolecular recognition site; other site
349521009126	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521009127	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
349521009128	membrane-bound complex binding site; other site
349521009129	hinge residues; other site
349521009130	OmpW family; Region: OmpW; cl17427
349521009131	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521009132	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521009133	ligand binding site [chemical binding]; other site
349521009134	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
349521009135	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521009136	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
349521009137	active site
349521009138	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
349521009139	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
349521009140	Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476
349521009141	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
349521009142	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
349521009143	acyl-activating enzyme (AAE) consensus motif; other site
349521009144	active site
349521009145	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
349521009146	Cytochrome P450; Region: p450; cl12078
349521009147	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
349521009148	Cytochrome P450; Region: p450; cl12078
349521009149	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
349521009150	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
349521009151	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
349521009152	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
349521009153	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521009154	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
349521009155	substrate binding pocket [chemical binding]; other site
349521009156	membrane-bound complex binding site; other site
349521009157	hinge residues; other site
349521009158	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
349521009159	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
349521009160	HAMP domain; Region: HAMP; pfam00672
349521009161	dimerization interface [polypeptide binding]; other site
349521009162	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521009163	dimer interface [polypeptide binding]; other site
349521009164	phosphorylation site [posttranslational modification]
349521009165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521009166	ATP binding site [chemical binding]; other site
349521009167	Mg2+ binding site [ion binding]; other site
349521009168	G-X-G motif; other site
349521009169	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
349521009170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009171	active site
349521009172	phosphorylation site [posttranslational modification]
349521009173	intermolecular recognition site; other site
349521009174	dimerization interface [polypeptide binding]; other site
349521009175	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521009176	DNA binding site [nucleotide binding]
349521009177	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
349521009178	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
349521009179	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
349521009180	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521009181	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521009182	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
349521009183	putative substrate binding pocket [chemical binding]; other site
349521009184	putative dimerization interface [polypeptide binding]; other site
349521009185	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
349521009186	EamA-like transporter family; Region: EamA; pfam00892
349521009187	Radical SAM superfamily; Region: Radical_SAM; pfam04055
349521009188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521009189	FeS/SAM binding site; other site
349521009190	agmatinase; Region: agmatinase; TIGR01230
349521009191	Agmatinase-like family; Region: Agmatinase-like; cd09990
349521009192	active site
349521009193	oligomer interface [polypeptide binding]; other site
349521009194	Mn binding site [ion binding]; other site
349521009195	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
349521009196	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
349521009197	ligand binding site [chemical binding]; other site
349521009198	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
349521009199	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521009200	ATP binding site [chemical binding]; other site
349521009201	putative Mg++ binding site [ion binding]; other site
349521009202	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521009203	nucleotide binding region [chemical binding]; other site
349521009204	ATP-binding site [chemical binding]; other site
349521009205	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
349521009206	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
349521009207	Beta-lactamase; Region: Beta-lactamase; pfam00144
349521009208	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
349521009209	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
349521009210	heme binding site [chemical binding]; other site
349521009211	ferroxidase pore; other site
349521009212	ferroxidase diiron center [ion binding]; other site
349521009213	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349521009214	Response regulator receiver domain; Region: Response_reg; pfam00072
349521009215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009216	active site
349521009217	phosphorylation site [posttranslational modification]
349521009218	intermolecular recognition site; other site
349521009219	dimerization interface [polypeptide binding]; other site
349521009220	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521009221	PAS domain; Region: PAS_9; pfam13426
349521009222	putative active site [active]
349521009223	heme pocket [chemical binding]; other site
349521009224	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
349521009225	diaminopimelate epimerase; Region: DapF; TIGR00652
349521009226	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
349521009227	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
349521009228	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521009229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521009230	putative substrate translocation pore; other site
349521009231	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
349521009232	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
349521009233	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
349521009234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521009235	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521009236	dimer interface [polypeptide binding]; other site
349521009237	phosphorylation site [posttranslational modification]
349521009238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521009239	ATP binding site [chemical binding]; other site
349521009240	Mg2+ binding site [ion binding]; other site
349521009241	G-X-G motif; other site
349521009242	Response regulator receiver domain; Region: Response_reg; pfam00072
349521009243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009244	active site
349521009245	phosphorylation site [posttranslational modification]
349521009246	intermolecular recognition site; other site
349521009247	dimerization interface [polypeptide binding]; other site
349521009248	Response regulator receiver domain; Region: Response_reg; pfam00072
349521009249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009250	active site
349521009251	phosphorylation site [posttranslational modification]
349521009252	intermolecular recognition site; other site
349521009253	dimerization interface [polypeptide binding]; other site
349521009254	PAS domain S-box; Region: sensory_box; TIGR00229
349521009255	PAS domain; Region: PAS_8; pfam13188
349521009256	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521009257	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521009258	metal binding site [ion binding]; metal-binding site
349521009259	active site
349521009260	I-site; other site
349521009261	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521009262	Response regulator receiver domain; Region: Response_reg; pfam00072
349521009263	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009264	active site
349521009265	phosphorylation site [posttranslational modification]
349521009266	intermolecular recognition site; other site
349521009267	dimerization interface [polypeptide binding]; other site
349521009268	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
349521009269	elongation factor G; Reviewed; Region: PRK12740
349521009270	G1 box; other site
349521009271	putative GEF interaction site [polypeptide binding]; other site
349521009272	GTP/Mg2+ binding site [chemical binding]; other site
349521009273	Switch I region; other site
349521009274	G2 box; other site
349521009275	G3 box; other site
349521009276	Switch II region; other site
349521009277	G4 box; other site
349521009278	G5 box; other site
349521009279	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
349521009280	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
349521009281	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
349521009282	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
349521009283	nucleotide binding site [chemical binding]; other site
349521009284	putative NEF/HSP70 interaction site [polypeptide binding]; other site
349521009285	SBD interface [polypeptide binding]; other site
349521009286	DNA-K related protein; Region: DUF3731; pfam12531
349521009287	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
349521009288	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
349521009289	nucleotide binding site [chemical binding]; other site
349521009290	putative NEF/HSP70 interaction site [polypeptide binding]; other site
349521009291	SBD interface [polypeptide binding]; other site
349521009292	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
349521009293	Transcriptional activator HlyU; Region: HlyU; pfam10115
349521009294	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
349521009295	CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081
349521009296	putative catalytic site [active]
349521009297	CdtC interface [polypeptide binding]; other site
349521009298	heterotrimer interface [polypeptide binding]; other site
349521009299	CdtA interface [polypeptide binding]; other site
349521009300	putative metal binding site [ion binding]; other site
349521009301	putative phosphate binding site [ion binding]; other site
349521009302	Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498
349521009303	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
349521009304	putative sugar binding sites [chemical binding]; other site
349521009305	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349521009306	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521009307	S-adenosylmethionine binding site [chemical binding]; other site
349521009308	Phytase; Region: Phytase; cl17685
349521009309	Predicted membrane protein [Function unknown]; Region: COG4325
349521009310	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
349521009311	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521009312	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349521009313	active site
349521009314	metal binding site [ion binding]; metal-binding site
349521009315	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
349521009316	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
349521009317	DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625
349521009318	putative ligand binding site [chemical binding]; other site
349521009319	Predicted membrane protein [Function unknown]; Region: COG2119
349521009320	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
349521009321	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
349521009322	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
349521009323	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
349521009324	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
349521009325	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
349521009326	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349521009327	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349521009328	catalytic residue [active]
349521009329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
349521009330	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
349521009331	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521009332	EamA-like transporter family; Region: EamA; pfam00892
349521009333	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521009334	Zn2+ binding site [ion binding]; other site
349521009335	Mg2+ binding site [ion binding]; other site
349521009336	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
349521009337	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
349521009338	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
349521009339	DNA binding residues [nucleotide binding]
349521009340	dimer interface [polypeptide binding]; other site
349521009341	putative metal binding site [ion binding]; other site
349521009342	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521009343	active site
349521009344	ATP binding site [chemical binding]; other site
349521009345	substrate binding site [chemical binding]; other site
349521009346	activation loop (A-loop); other site
349521009347	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
349521009348	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349521009349	E3 interaction surface; other site
349521009350	lipoyl attachment site [posttranslational modification]; other site
349521009351	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349521009352	E3 interaction surface; other site
349521009353	lipoyl attachment site [posttranslational modification]; other site
349521009354	e3 binding domain; Region: E3_binding; pfam02817
349521009355	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
349521009356	3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182
349521009357	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
349521009358	alpha subunit interface [polypeptide binding]; other site
349521009359	TPP binding site [chemical binding]; other site
349521009360	heterodimer interface [polypeptide binding]; other site
349521009361	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349521009362	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
349521009363	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
349521009364	tetramer interface [polypeptide binding]; other site
349521009365	TPP-binding site [chemical binding]; other site
349521009366	heterodimer interface [polypeptide binding]; other site
349521009367	phosphorylation loop region [posttranslational modification]
349521009368	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521009369	EamA-like transporter family; Region: EamA; pfam00892
349521009370	EamA-like transporter family; Region: EamA; pfam00892
349521009371	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
349521009372	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
349521009373	dimer interface [polypeptide binding]; other site
349521009374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521009375	catalytic residue [active]
349521009376	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
349521009377	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842
349521009378	dimer interface [polypeptide binding]; other site
349521009379	active site
349521009380	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349521009381	catalytic residues [active]
349521009382	substrate binding site [chemical binding]; other site
349521009383	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
349521009384	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
349521009385	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
349521009386	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521009387	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521009388	dimerization interface [polypeptide binding]; other site
349521009389	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
349521009390	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
349521009391	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
349521009392	Heme NO binding; Region: HNOB; pfam07700
349521009393	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521009394	dimer interface [polypeptide binding]; other site
349521009395	phosphorylation site [posttranslational modification]
349521009396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521009397	ATP binding site [chemical binding]; other site
349521009398	Mg2+ binding site [ion binding]; other site
349521009399	G-X-G motif; other site
349521009400	Response regulator receiver domain; Region: Response_reg; pfam00072
349521009401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009402	active site
349521009403	phosphorylation site [posttranslational modification]
349521009404	intermolecular recognition site; other site
349521009405	dimerization interface [polypeptide binding]; other site
349521009406	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521009407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009408	active site
349521009409	phosphorylation site [posttranslational modification]
349521009410	intermolecular recognition site; other site
349521009411	dimerization interface [polypeptide binding]; other site
349521009412	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
349521009413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009414	active site
349521009415	phosphorylation site [posttranslational modification]
349521009416	intermolecular recognition site; other site
349521009417	CheB methylesterase; Region: CheB_methylest; pfam01339
349521009418	CheD chemotactic sensory transduction; Region: CheD; cl00810
349521009419	CheD chemotactic sensory transduction; Region: CheD; cl00810
349521009420	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
349521009421	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
349521009422	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
349521009423	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
349521009424	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
349521009425	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
349521009426	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521009427	dimerization interface [polypeptide binding]; other site
349521009428	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521009429	dimer interface [polypeptide binding]; other site
349521009430	putative CheW interface [polypeptide binding]; other site
349521009431	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
349521009432	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521009433	putative binding surface; other site
349521009434	active site
349521009435	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
349521009436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521009437	ATP binding site [chemical binding]; other site
349521009438	Mg2+ binding site [ion binding]; other site
349521009439	G-X-G motif; other site
349521009440	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
349521009441	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349521009442	anti sigma factor interaction site; other site
349521009443	regulatory phosphorylation site [posttranslational modification]; other site
349521009444	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521009445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009446	active site
349521009447	phosphorylation site [posttranslational modification]
349521009448	intermolecular recognition site; other site
349521009449	dimerization interface [polypeptide binding]; other site
349521009450	Response regulator receiver domain; Region: Response_reg; pfam00072
349521009451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009452	active site
349521009453	phosphorylation site [posttranslational modification]
349521009454	intermolecular recognition site; other site
349521009455	dimerization interface [polypeptide binding]; other site
349521009456	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521009457	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521009458	metal binding site [ion binding]; metal-binding site
349521009459	active site
349521009460	I-site; other site
349521009461	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521009462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009463	active site
349521009464	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521009465	phosphorylation site [posttranslational modification]
349521009466	intermolecular recognition site; other site
349521009467	dimerization interface [polypeptide binding]; other site
349521009468	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521009469	dimer interface [polypeptide binding]; other site
349521009470	phosphorylation site [posttranslational modification]
349521009471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521009472	ATP binding site [chemical binding]; other site
349521009473	Mg2+ binding site [ion binding]; other site
349521009474	G-X-G motif; other site
349521009475	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521009476	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
349521009477	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
349521009478	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349521009479	MgtE intracellular N domain; Region: MgtE_N; pfam03448
349521009480	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
349521009481	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
349521009482	MgtE intracellular N domain; Region: MgtE_N; pfam03448
349521009483	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
349521009484	Divalent cation transporter; Region: MgtE; cl00786
349521009485	Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405
349521009486	short chain dehydrogenase; Provisional; Region: PRK06500
349521009487	classical (c) SDRs; Region: SDR_c; cd05233
349521009488	NAD(P) binding site [chemical binding]; other site
349521009489	active site
349521009490	Predicted transcriptional regulators [Transcription]; Region: COG1733
349521009491	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
349521009492	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
349521009493	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
349521009494	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
349521009495	putative metal binding site [ion binding]; other site
349521009496	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
349521009497	Peptidase M66; Region: Peptidase_M66; pfam10462
349521009498	Predicted acetyltransferase [General function prediction only]; Region: COG3153
349521009499	hypothetical protein; Provisional; Region: PRK13687
349521009500	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
349521009501	dimerization interface [polypeptide binding]; other site
349521009502	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521009503	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
349521009504	dimer interface [polypeptide binding]; other site
349521009505	putative CheW interface [polypeptide binding]; other site
349521009506	cystine transporter subunit; Provisional; Region: PRK11260
349521009507	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521009508	substrate binding pocket [chemical binding]; other site
349521009509	membrane-bound complex binding site; other site
349521009510	hinge residues; other site
349521009511	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
349521009512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521009513	dimer interface [polypeptide binding]; other site
349521009514	conserved gate region; other site
349521009515	putative PBP binding loops; other site
349521009516	ABC-ATPase subunit interface; other site
349521009517	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
349521009518	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
349521009519	Walker A/P-loop; other site
349521009520	ATP binding site [chemical binding]; other site
349521009521	Q-loop/lid; other site
349521009522	ABC transporter signature motif; other site
349521009523	Walker B; other site
349521009524	D-loop; other site
349521009525	H-loop/switch region; other site
349521009526	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
349521009527	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
349521009528	catalytic triad [active]
349521009529	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
349521009530	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521009531	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521009532	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521009533	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349521009534	Protein export membrane protein; Region: SecD_SecF; cl14618
349521009535	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
349521009536	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
349521009537	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521009538	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521009539	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521009540	RHS protein; Region: RHS; pfam03527
349521009541	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521009542	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521009543	RHS protein; Region: RHS; pfam03527
349521009544	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521009545	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521009546	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521009547	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521009548	RHS protein; Region: RHS; pfam03527
349521009549	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521009550	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521009551	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521009552	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521009553	RHS Repeat; Region: RHS_repeat; cl11982
349521009554	RHS Repeat; Region: RHS_repeat; pfam05593
349521009555	RHS Repeat; Region: RHS_repeat; pfam05593
349521009556	RHS Repeat; Region: RHS_repeat; pfam05593
349521009557	RHS Repeat; Region: RHS_repeat; pfam05593
349521009558	RHS protein; Region: RHS; pfam03527
349521009559	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521009560	ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346
349521009561	NAD binding site [chemical binding]; other site
349521009562	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
349521009563	Mg2+ binding site [ion binding]; other site
349521009564	G-X-G motif; other site
349521009565	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
349521009566	ATP binding site [chemical binding]; other site
349521009567	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
349521009568	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
349521009569	dimer interface [polypeptide binding]; other site
349521009570	active site
349521009571	metal binding site [ion binding]; metal-binding site
349521009572	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
349521009573	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
349521009574	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521009575	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521009576	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
349521009577	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
349521009578	siderophore binding site; other site
349521009579	enterobactin exporter EntS; Provisional; Region: PRK10489
349521009580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521009581	putative substrate translocation pore; other site
349521009582	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
349521009583	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521009584	ABC-ATPase subunit  interface; other site
349521009585	dimer interface [polypeptide binding]; other site
349521009586	putative PBP binding regions; other site
349521009587	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
349521009588	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521009589	ABC-ATPase subunit  interface; other site
349521009590	dimer interface [polypeptide binding]; other site
349521009591	putative PBP binding regions; other site
349521009592	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
349521009593	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
349521009594	Walker A/P-loop; other site
349521009595	ATP binding site [chemical binding]; other site
349521009596	Q-loop/lid; other site
349521009597	ABC transporter signature motif; other site
349521009598	Walker B; other site
349521009599	D-loop; other site
349521009600	H-loop/switch region; other site
349521009601	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521009602	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521009603	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
349521009604	N-terminal domain interface [polypeptide binding]; other site
349521009605	dimer interface [polypeptide binding]; other site
349521009606	substrate binding pocket (H-site) [chemical binding]; other site
349521009607	Predicted membrane protein [Function unknown]; Region: COG2259
349521009608	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521009609	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521009610	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521009611	dimerization interface [polypeptide binding]; other site
349521009612	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
349521009613	putative catalytic site [active]
349521009614	putative metal binding site [ion binding]; other site
349521009615	putative phosphate binding site [ion binding]; other site
349521009616	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
349521009617	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521009618	ATP binding site [chemical binding]; other site
349521009619	putative Mg++ binding site [ion binding]; other site
349521009620	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521009621	ATP-binding site [chemical binding]; other site
349521009622	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
349521009623	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
349521009624	putative active site [active]
349521009625	DEAD-like helicases superfamily; Region: DEXDc; smart00487
349521009626	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521009627	ATP binding site [chemical binding]; other site
349521009628	putative Mg++ binding site [ion binding]; other site
349521009629	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
349521009630	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521009631	nucleotide binding region [chemical binding]; other site
349521009632	ATP-binding site [chemical binding]; other site
349521009633	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
349521009634	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
349521009635	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
349521009636	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
349521009637	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
349521009638	putative toxin YafO; Provisional; Region: PRK09885
349521009639	primosomal protein DnaI; Provisional; Region: PRK02854
349521009640	Condensation domain; Region: Condensation; pfam00668
349521009641	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
349521009642	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521009643	acyl-activating enzyme (AAE) consensus motif; other site
349521009644	AMP binding site [chemical binding]; other site
349521009645	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521009646	Condensation domain; Region: Condensation; pfam00668
349521009647	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
349521009648	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
349521009649	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521009650	acyl-activating enzyme (AAE) consensus motif; other site
349521009651	AMP binding site [chemical binding]; other site
349521009652	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521009653	MbtH-like protein; Region: MbtH; pfam03621
349521009654	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
349521009655	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
349521009656	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
349521009657	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
349521009658	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521009659	N-terminal plug; other site
349521009660	ligand-binding site [chemical binding]; other site
349521009661	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
349521009662	nudix motif; other site
349521009663	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
349521009664	nudix motif; other site
349521009665	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
349521009666	active site
349521009667	metal binding site [ion binding]; metal-binding site
349521009668	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521009669	Isochorismatase family; Region: Isochorismatase; pfam00857
349521009670	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
349521009671	catalytic triad [active]
349521009672	conserved cis-peptide bond; other site
349521009673	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521009674	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521009675	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521009676	putative effector binding pocket; other site
349521009677	dimerization interface [polypeptide binding]; other site
349521009678	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
349521009679	FeoA domain; Region: FeoA; pfam04023
349521009680	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
349521009681	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
349521009682	G1 box; other site
349521009683	GTP/Mg2+ binding site [chemical binding]; other site
349521009684	Switch I region; other site
349521009685	G2 box; other site
349521009686	G3 box; other site
349521009687	Switch II region; other site
349521009688	G4 box; other site
349521009689	G5 box; other site
349521009690	Nucleoside recognition; Region: Gate; pfam07670
349521009691	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
349521009692	Nucleoside recognition; Region: Gate; pfam07670
349521009693	FeoC like transcriptional regulator; Region: FeoC; pfam09012
349521009694	Fatty acid desaturase; Region: FA_desaturase; pfam00487
349521009695	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
349521009696	putative di-iron ligands [ion binding]; other site
349521009697	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
349521009698	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
349521009699	FAD binding pocket [chemical binding]; other site
349521009700	FAD binding motif [chemical binding]; other site
349521009701	phosphate binding motif [ion binding]; other site
349521009702	beta-alpha-beta structure motif; other site
349521009703	NAD binding pocket [chemical binding]; other site
349521009704	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349521009705	catalytic loop [active]
349521009706	iron binding site [ion binding]; other site
349521009707	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
349521009708	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521009709	active site
349521009710	Response regulator receiver domain; Region: Response_reg; pfam00072
349521009711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009712	active site
349521009713	phosphorylation site [posttranslational modification]
349521009714	intermolecular recognition site; other site
349521009715	dimerization interface [polypeptide binding]; other site
349521009716	GAF domain; Region: GAF_2; pfam13185
349521009717	GAF domain; Region: GAF_3; pfam13492
349521009718	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521009719	PAS domain; Region: PAS_9; pfam13426
349521009720	putative active site [active]
349521009721	heme pocket [chemical binding]; other site
349521009722	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521009723	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521009724	metal binding site [ion binding]; metal-binding site
349521009725	active site
349521009726	I-site; other site
349521009727	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521009728	Response regulator receiver domain; Region: Response_reg; pfam00072
349521009729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009730	active site
349521009731	phosphorylation site [posttranslational modification]
349521009732	intermolecular recognition site; other site
349521009733	dimerization interface [polypeptide binding]; other site
349521009734	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
349521009735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009736	active site
349521009737	phosphorylation site [posttranslational modification]
349521009738	intermolecular recognition site; other site
349521009739	dimerization interface [polypeptide binding]; other site
349521009740	CheB methylesterase; Region: CheB_methylest; pfam01339
349521009741	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521009742	putative binding surface; other site
349521009743	active site
349521009744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521009745	ATP binding site [chemical binding]; other site
349521009746	Mg2+ binding site [ion binding]; other site
349521009747	G-X-G motif; other site
349521009748	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
349521009749	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521009750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009751	active site
349521009752	phosphorylation site [posttranslational modification]
349521009753	intermolecular recognition site; other site
349521009754	dimerization interface [polypeptide binding]; other site
349521009755	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
349521009756	HAMP domain; Region: HAMP; pfam00672
349521009757	dimerization interface [polypeptide binding]; other site
349521009758	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521009759	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521009760	dimer interface [polypeptide binding]; other site
349521009761	putative CheW interface [polypeptide binding]; other site
349521009762	CheW-like domain; Region: CheW; pfam01584
349521009763	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
349521009764	TPR repeat; Region: TPR_11; pfam13414
349521009765	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521009766	binding surface
349521009767	TPR motif; other site
349521009768	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
349521009769	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
349521009770	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521009771	active site
349521009772	motif I; other site
349521009773	motif II; other site
349521009774	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
349521009775	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
349521009776	G1 box; other site
349521009777	GTP/Mg2+ binding site [chemical binding]; other site
349521009778	G2 box; other site
349521009779	Switch I region; other site
349521009780	G3 box; other site
349521009781	Switch II region; other site
349521009782	G5 box; other site
349521009783	Domain of unknown function (DUF3482); Region: DUF3482; pfam11981
349521009784	Protein of unknown function (DUF2868); Region: DUF2868; pfam11067
349521009785	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521009786	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
349521009787	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
349521009788	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
349521009789	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
349521009790	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
349521009791	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
349521009792	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
349521009793	dimer interface [polypeptide binding]; other site
349521009794	active site
349521009795	glycine-pyridoxal phosphate binding site [chemical binding]; other site
349521009796	folate binding site [chemical binding]; other site
349521009797	glycine dehydrogenase; Provisional; Region: PRK05367
349521009798	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
349521009799	tetramer interface [polypeptide binding]; other site
349521009800	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521009801	catalytic residue [active]
349521009802	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
349521009803	tetramer interface [polypeptide binding]; other site
349521009804	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521009805	catalytic residue [active]
349521009806	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
349521009807	lipoyl attachment site [posttranslational modification]; other site
349521009808	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521009809	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521009810	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521009811	dimerization interface [polypeptide binding]; other site
349521009812	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521009813	PAS fold; Region: PAS_3; pfam08447
349521009814	putative active site [active]
349521009815	heme pocket [chemical binding]; other site
349521009816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521009817	PAS domain; Region: PAS_9; pfam13426
349521009818	putative active site [active]
349521009819	heme pocket [chemical binding]; other site
349521009820	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521009821	PAS domain; Region: PAS_9; pfam13426
349521009822	putative active site [active]
349521009823	heme pocket [chemical binding]; other site
349521009824	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521009825	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521009826	metal binding site [ion binding]; metal-binding site
349521009827	active site
349521009828	I-site; other site
349521009829	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521009830	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
349521009831	dimer interface [polypeptide binding]; other site
349521009832	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521009833	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521009834	DNA binding site [nucleotide binding]
349521009835	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521009836	binding surface
349521009837	TPR motif; other site
349521009838	TPR repeat; Region: TPR_11; pfam13414
349521009839	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521009840	binding surface
349521009841	TPR motif; other site
349521009842	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349521009843	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
349521009844	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
349521009845	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
349521009846	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349521009847	Helix-turn-helix domain; Region: HTH_18; pfam12833
349521009848	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521009849	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
349521009850	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521009851	Walker A/P-loop; other site
349521009852	ATP binding site [chemical binding]; other site
349521009853	Q-loop/lid; other site
349521009854	ABC transporter signature motif; other site
349521009855	Walker B; other site
349521009856	D-loop; other site
349521009857	H-loop/switch region; other site
349521009858	ABC transporter; Region: ABC_tran_2; pfam12848
349521009859	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521009860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521009861	S-adenosylmethionine binding site [chemical binding]; other site
349521009862	Pleckstrin homology-like domain; Region: PH-like; cl17171
349521009863	maltose O-acetyltransferase; Provisional; Region: PRK10092
349521009864	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
349521009865	active site
349521009866	substrate binding site [chemical binding]; other site
349521009867	trimer interface [polypeptide binding]; other site
349521009868	CoA binding site [chemical binding]; other site
349521009869	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
349521009870	putative hydrophobic ligand binding site [chemical binding]; other site
349521009871	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
349521009872	putative active site [active]
349521009873	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
349521009874	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
349521009875	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
349521009876	active site
349521009877	catalytic residues [active]
349521009878	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349521009879	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521009880	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521009881	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521009882	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521009883	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521009884	dimerization interface [polypeptide binding]; other site
349521009885	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
349521009886	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349521009887	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521009888	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
349521009889	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349521009890	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521009891	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
349521009892	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
349521009893	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521009894	Cadherin repeat-like domain; Region: CA_like; cl15786
349521009895	Ca2+ binding site [ion binding]; other site
349521009896	Cadherin repeat-like domain; Region: CA_like; cl15786
349521009897	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521009898	Ca2+ binding site [ion binding]; other site
349521009899	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
349521009900	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521009901	Cadherin repeat-like domain; Region: CA_like; cl15786
349521009902	Ca2+ binding site [ion binding]; other site
349521009903	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
349521009904	Cadherin repeat-like domain; Region: CA_like; cl15786
349521009905	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
349521009906	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349521009907	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
349521009908	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521009909	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521009910	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521009911	putative effector binding pocket; other site
349521009912	dimerization interface [polypeptide binding]; other site
349521009913	chorismate mutase; Provisional; Region: PRK08055
349521009914	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
349521009915	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
349521009916	Ca binding site [ion binding]; other site
349521009917	ligand binding site I [chemical binding]; other site
349521009918	homodimer interface [polypeptide binding]; other site
349521009919	ligand binding site II [chemical binding]; other site
349521009920	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
349521009921	Ca binding site [ion binding]; other site
349521009922	ligand binding site I [chemical binding]; other site
349521009923	homodimer interface [polypeptide binding]; other site
349521009924	ligand binding site II [chemical binding]; other site
349521009925	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
349521009926	active site
349521009927	Zn binding site [ion binding]; other site
349521009928	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
349521009929	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
349521009930	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
349521009931	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521009932	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521009933	dimerization interface [polypeptide binding]; other site
349521009934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521009935	dimer interface [polypeptide binding]; other site
349521009936	phosphorylation site [posttranslational modification]
349521009937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521009938	ATP binding site [chemical binding]; other site
349521009939	Mg2+ binding site [ion binding]; other site
349521009940	G-X-G motif; other site
349521009941	Response regulator receiver domain; Region: Response_reg; pfam00072
349521009942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521009943	active site
349521009944	phosphorylation site [posttranslational modification]
349521009945	intermolecular recognition site; other site
349521009946	dimerization interface [polypeptide binding]; other site
349521009947	glutathione reductase; Validated; Region: PRK06116
349521009948	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349521009949	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521009950	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349521009951	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349521009952	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521009953	Coenzyme A binding pocket [chemical binding]; other site
349521009954	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
349521009955	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
349521009956	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
349521009957	GspL periplasmic domain; Region: GspL_C; pfam12693
349521009958	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
349521009959	type II secretion system protein J; Region: gspJ; TIGR01711
349521009960	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
349521009961	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
349521009962	type II secretion system protein I; Region: gspI; TIGR01707
349521009963	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
349521009964	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
349521009965	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
349521009966	type II secretion system protein F; Region: GspF; TIGR02120
349521009967	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349521009968	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349521009969	type II secretion system protein E; Region: type_II_gspE; TIGR02533
349521009970	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
349521009971	Walker A motif; other site
349521009972	ATP binding site [chemical binding]; other site
349521009973	Walker B motif; other site
349521009974	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
349521009975	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
349521009976	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
349521009977	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
349521009978	DNA binding residues [nucleotide binding]
349521009979	putative dimer interface [polypeptide binding]; other site
349521009980	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
349521009981	isovaleryl-CoA dehydrogenase; Region: PLN02519
349521009982	substrate binding site [chemical binding]; other site
349521009983	FAD binding site [chemical binding]; other site
349521009984	catalytic base [active]
349521009985	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
349521009986	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
349521009987	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
349521009988	enoyl-CoA hydratase; Provisional; Region: PRK05995
349521009989	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521009990	substrate binding site [chemical binding]; other site
349521009991	oxyanion hole (OAH) forming residues; other site
349521009992	trimer interface [polypeptide binding]; other site
349521009993	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
349521009994	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349521009995	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
349521009996	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
349521009997	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349521009998	carboxyltransferase (CT) interaction site; other site
349521009999	biotinylation site [posttranslational modification]; other site
349521010000	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
349521010001	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
349521010002	active site
349521010003	catalytic residues [active]
349521010004	metal binding site [ion binding]; metal-binding site
349521010005	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
349521010006	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
349521010007	acyl-activating enzyme (AAE) consensus motif; other site
349521010008	putative AMP binding site [chemical binding]; other site
349521010009	putative active site [active]
349521010010	putative CoA binding site [chemical binding]; other site
349521010011	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
349521010012	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
349521010013	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
349521010014	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
349521010015	Ligand binding site [chemical binding]; other site
349521010016	Electron transfer flavoprotein domain; Region: ETF; pfam01012
349521010017	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
349521010018	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349521010019	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
349521010020	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
349521010021	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
349521010022	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349521010023	putative active site [active]
349521010024	putative NTP binding site [chemical binding]; other site
349521010025	putative nucleic acid binding site [nucleotide binding]; other site
349521010026	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
349521010027	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
349521010028	active site
349521010029	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349521010030	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
349521010031	putative active site [active]
349521010032	putative NTP binding site [chemical binding]; other site
349521010033	putative nucleic acid binding site [nucleotide binding]; other site
349521010034	WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998
349521010035	HEAT repeats; Region: HEAT_2; pfam13646
349521010036	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521010037	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
349521010038	putative ADP-binding pocket [chemical binding]; other site
349521010039	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
349521010040	Uncharacterized conserved protein [Function unknown]; Region: COG0398
349521010041	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
349521010042	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
349521010043	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521010044	Zn2+ binding site [ion binding]; other site
349521010045	Mg2+ binding site [ion binding]; other site
349521010046	Protein required for attachment to host cells; Region: Host_attach; pfam10116
349521010047	N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211
349521010048	Chitin binding domain; Region: Chitin_bind_3; pfam03067
349521010049	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349521010050	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521010051	NAD(P) binding site [chemical binding]; other site
349521010052	active site
349521010053	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
349521010054	putative catalytic residues [active]
349521010055	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
349521010056	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
349521010057	Mechanosensitive ion channel; Region: MS_channel; pfam00924
349521010058	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
349521010059	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
349521010060	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521010061	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521010062	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349521010063	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349521010064	active site
349521010065	catalytic tetrad [active]
349521010066	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
349521010067	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521010068	Coenzyme A binding pocket [chemical binding]; other site
349521010069	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
349521010070	active site
349521010071	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
349521010072	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521010073	FeS/SAM binding site; other site
349521010074	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
349521010075	DGC domain; Region: DGC; pfam08859
349521010076	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521010077	salt bridge; other site
349521010078	non-specific DNA binding site [nucleotide binding]; other site
349521010079	sequence-specific DNA binding site [nucleotide binding]; other site
349521010080	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
349521010081	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
349521010082	Domain of unknown function (DUF4288); Region: DUF4288; pfam14119
349521010083	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521010084	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521010085	putative substrate translocation pore; other site
349521010086	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
349521010087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521010088	putative substrate translocation pore; other site
349521010089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521010090	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
349521010091	Protein phosphatase 2C; Region: PP2C; pfam00481
349521010092	active site
349521010093	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
349521010094	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521010095	active site
349521010096	ATP binding site [chemical binding]; other site
349521010097	substrate binding site [chemical binding]; other site
349521010098	activation loop (A-loop); other site
349521010099	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521010100	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521010101	substrate binding pocket [chemical binding]; other site
349521010102	membrane-bound complex binding site; other site
349521010103	hinge residues; other site
349521010104	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
349521010105	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
349521010106	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349521010107	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
349521010108	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
349521010109	malate:quinone oxidoreductase; Validated; Region: PRK05257
349521010110	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
349521010111	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
349521010112	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
349521010113	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
349521010114	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
349521010115	4Fe-4S binding domain; Region: Fer4_6; pfam12837
349521010116	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
349521010117	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
349521010118	[4Fe-4S] binding site [ion binding]; other site
349521010119	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349521010120	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349521010121	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349521010122	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
349521010123	molybdopterin cofactor binding site; other site
349521010124	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
349521010125	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
349521010126	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521010127	dimerization interface [polypeptide binding]; other site
349521010128	Histidine kinase; Region: HisKA_3; pfam07730
349521010129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010130	ATP binding site [chemical binding]; other site
349521010131	Mg2+ binding site [ion binding]; other site
349521010132	G-X-G motif; other site
349521010133	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
349521010134	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
349521010135	Active Sites [active]
349521010136	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
349521010137	metal binding triad [ion binding]; metal-binding site
349521010138	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
349521010139	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
349521010140	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
349521010141	Cu(I) binding site [ion binding]; other site
349521010142	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
349521010143	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
349521010144	transcriptional regulator NarL; Provisional; Region: PRK10651
349521010145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010146	active site
349521010147	phosphorylation site [posttranslational modification]
349521010148	intermolecular recognition site; other site
349521010149	dimerization interface [polypeptide binding]; other site
349521010150	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521010151	DNA binding residues [nucleotide binding]
349521010152	dimerization interface [polypeptide binding]; other site
349521010153	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
349521010154	Cation efflux family; Region: Cation_efflux; pfam01545
349521010155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
349521010156	dimer interface [polypeptide binding]; other site
349521010157	phosphorylation site [posttranslational modification]
349521010158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010159	ATP binding site [chemical binding]; other site
349521010160	Mg2+ binding site [ion binding]; other site
349521010161	G-X-G motif; other site
349521010162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010163	Response regulator receiver domain; Region: Response_reg; pfam00072
349521010164	active site
349521010165	phosphorylation site [posttranslational modification]
349521010166	intermolecular recognition site; other site
349521010167	dimerization interface [polypeptide binding]; other site
349521010168	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
349521010169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010170	active site
349521010171	phosphorylation site [posttranslational modification]
349521010172	intermolecular recognition site; other site
349521010173	dimerization interface [polypeptide binding]; other site
349521010174	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521010175	Zn2+ binding site [ion binding]; other site
349521010176	Mg2+ binding site [ion binding]; other site
349521010177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010178	ATP binding site [chemical binding]; other site
349521010179	Mg2+ binding site [ion binding]; other site
349521010180	G-X-G motif; other site
349521010181	HDOD domain; Region: HDOD; pfam08668
349521010182	Response regulator receiver domain; Region: Response_reg; pfam00072
349521010183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010184	active site
349521010185	phosphorylation site [posttranslational modification]
349521010186	intermolecular recognition site; other site
349521010187	dimerization interface [polypeptide binding]; other site
349521010188	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349521010189	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349521010190	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521010191	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521010192	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521010193	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
349521010194	PAS domain; Region: PAS_9; pfam13426
349521010195	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521010196	putative active site [active]
349521010197	heme pocket [chemical binding]; other site
349521010198	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521010199	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521010200	metal binding site [ion binding]; metal-binding site
349521010201	active site
349521010202	I-site; other site
349521010203	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521010204	Domain of unknown function (DUF1704); Region: DUF1704; pfam08014
349521010205	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521010206	Coenzyme A binding pocket [chemical binding]; other site
349521010207	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
349521010208	Predicted amidohydrolase [General function prediction only]; Region: COG0388
349521010209	putative active site [active]
349521010210	catalytic triad [active]
349521010211	putative dimer interface [polypeptide binding]; other site
349521010212	response regulator; Provisional; Region: PRK09483
349521010213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010214	active site
349521010215	phosphorylation site [posttranslational modification]
349521010216	intermolecular recognition site; other site
349521010217	dimerization interface [polypeptide binding]; other site
349521010218	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521010219	DNA binding residues [nucleotide binding]
349521010220	dimerization interface [polypeptide binding]; other site
349521010221	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
349521010222	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
349521010223	GIY-YIG motif/motif A; other site
349521010224	active site
349521010225	catalytic site [active]
349521010226	putative DNA binding site [nucleotide binding]; other site
349521010227	metal binding site [ion binding]; metal-binding site
349521010228	UvrB/uvrC motif; Region: UVR; pfam02151
349521010229	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
349521010230	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
349521010231	DNA binding site [nucleotide binding]
349521010232	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
349521010233	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
349521010234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
349521010235	FtsH Extracellular; Region: FtsH_ext; pfam06480
349521010236	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
349521010237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521010238	Walker A motif; other site
349521010239	ATP binding site [chemical binding]; other site
349521010240	Walker B motif; other site
349521010241	arginine finger; other site
349521010242	Peptidase family M41; Region: Peptidase_M41; pfam01434
349521010243	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
349521010244	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
349521010245	putative dimer interface [polypeptide binding]; other site
349521010246	TfoX C-terminal domain; Region: TfoX_C; pfam04994
349521010247	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521010248	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
349521010249	active site residue [active]
349521010250	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
349521010251	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
349521010252	conserved cys residue [active]
349521010253	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521010254	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521010255	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521010256	substrate binding pocket [chemical binding]; other site
349521010257	membrane-bound complex binding site; other site
349521010258	hinge residues; other site
349521010259	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521010260	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521010261	substrate binding pocket [chemical binding]; other site
349521010262	membrane-bound complex binding site; other site
349521010263	hinge residues; other site
349521010264	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521010265	RHS Repeat; Region: RHS_repeat; pfam05593
349521010266	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521010267	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521010268	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521010269	RHS Repeat; Region: RHS_repeat; pfam05593
349521010270	RHS Repeat; Region: RHS_repeat; pfam05593
349521010271	RHS Repeat; Region: RHS_repeat; pfam05593
349521010272	RHS Repeat; Region: RHS_repeat; pfam05593
349521010273	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521010274	TPR repeat; Region: TPR_11; pfam13414
349521010275	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521010276	binding surface
349521010277	TPR motif; other site
349521010278	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
349521010279	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
349521010280	flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397
349521010281	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
349521010282	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
349521010283	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
349521010284	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
349521010285	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
349521010286	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
349521010287	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
349521010288	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
349521010289	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349521010290	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
349521010291	Walker A motif/ATP binding site; other site
349521010292	Walker B motif; other site
349521010293	Flagellar assembly protein FliH; Region: FliH; pfam02108
349521010294	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
349521010295	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
349521010296	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
349521010297	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
349521010298	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
349521010299	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349521010300	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
349521010301	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
349521010302	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
349521010303	Flagellar L-ring protein; Region: FlgH; cl17277
349521010304	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
349521010305	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
349521010306	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349521010307	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349521010308	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
349521010309	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
349521010310	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
349521010311	FHIPEP family; Region: FHIPEP; pfam00771
349521010312	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
349521010313	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
349521010314	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
349521010315	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
349521010316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521010317	TPR motif; other site
349521010318	binding surface
349521010319	TPR repeat; Region: TPR_11; pfam13414
349521010320	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521010321	TPR motif; other site
349521010322	binding surface
349521010323	Tetratricopeptide repeat; Region: TPR_12; pfam13424
349521010324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521010325	TPR motif; other site
349521010326	binding surface
349521010327	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521010328	binding surface
349521010329	TPR motif; other site
349521010330	Mitochondria Fission Protein Fis1, cytosolic domain; Region: Fis1; cd12212
349521010331	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521010332	MltA-interacting protein MipA; Region: MipA; cl01504
349521010333	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
349521010334	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
349521010335	ATP binding site [chemical binding]; other site
349521010336	substrate interface [chemical binding]; other site
349521010337	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
349521010338	active site residue [active]
349521010339	VPS10 domain; Region: VPS10; smart00602
349521010340	Ubiquitin-like proteins; Region: UBQ; cl00155
349521010341	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
349521010342	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
349521010343	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521010344	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
349521010345	amidase catalytic site [active]
349521010346	Zn binding residues [ion binding]; other site
349521010347	substrate binding site [chemical binding]; other site
349521010348	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
349521010349	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
349521010350	putative metal binding site [ion binding]; other site
349521010351	Predicted ATPase [General function prediction only]; Region: COG4637
349521010352	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521010353	Walker A/P-loop; other site
349521010354	ATP binding site [chemical binding]; other site
349521010355	EamA-like transporter family; Region: EamA; pfam00892
349521010356	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
349521010357	EamA-like transporter family; Region: EamA; pfam00892
349521010358	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
349521010359	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
349521010360	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
349521010361	Ca binding site [ion binding]; other site
349521010362	ligand binding site I [chemical binding]; other site
349521010363	ligand binding site II [chemical binding]; other site
349521010364	homodimer interface [polypeptide binding]; other site
349521010365	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
349521010366	active site clefts [active]
349521010367	zinc binding site [ion binding]; other site
349521010368	dimer interface [polypeptide binding]; other site
349521010369	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
349521010370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010371	active site
349521010372	phosphorylation site [posttranslational modification]
349521010373	intermolecular recognition site; other site
349521010374	dimerization interface [polypeptide binding]; other site
349521010375	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521010376	DNA binding site [nucleotide binding]
349521010377	sensor protein RstB; Provisional; Region: PRK10604
349521010378	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521010379	dimerization interface [polypeptide binding]; other site
349521010380	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521010381	dimer interface [polypeptide binding]; other site
349521010382	phosphorylation site [posttranslational modification]
349521010383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010384	ATP binding site [chemical binding]; other site
349521010385	Mg2+ binding site [ion binding]; other site
349521010386	G-X-G motif; other site
349521010387	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
349521010388	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
349521010389	active site triad [active]
349521010390	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
349521010391	NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272
349521010392	Predicted flavoproteins [General function prediction only]; Region: COG2081
349521010393	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349521010394	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521010395	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
349521010396	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521010397	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521010398	dimer interface [polypeptide binding]; other site
349521010399	phosphorylation site [posttranslational modification]
349521010400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
349521010401	ATP binding site [chemical binding]; other site
349521010402	Mg2+ binding site [ion binding]; other site
349521010403	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521010404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010405	active site
349521010406	phosphorylation site [posttranslational modification]
349521010407	intermolecular recognition site; other site
349521010408	dimerization interface [polypeptide binding]; other site
349521010409	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521010410	DNA binding site [nucleotide binding]
349521010411	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349521010412	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521010413	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521010414	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521010415	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
349521010416	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
349521010417	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521010418	putative binding surface; other site
349521010419	active site
349521010420	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521010421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
349521010422	active site
349521010423	phosphorylation site [posttranslational modification]
349521010424	intermolecular recognition site; other site
349521010425	dimerization interface [polypeptide binding]; other site
349521010426	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521010427	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521010428	metal binding site [ion binding]; metal-binding site
349521010429	active site
349521010430	I-site; other site
349521010431	Patatin-like phospholipase; Region: Patatin; pfam01734
349521010432	active site
349521010433	nucleophile elbow; other site
349521010434	Putative amidotransferase; Region: DUF4066; pfam13278
349521010435	conserved cys residue [active]
349521010436	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
349521010437	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
349521010438	maltodextrin glucosidase; Provisional; Region: PRK10785
349521010439	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
349521010440	homodimer interface [polypeptide binding]; other site
349521010441	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
349521010442	active site
349521010443	homodimer interface [polypeptide binding]; other site
349521010444	catalytic site [active]
349521010445	Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317
349521010446	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
349521010447	active site
349521010448	Ca binding site [ion binding]; other site
349521010449	catalytic site [active]
349521010450	Aamy_C domain; Region: Aamy_C; smart00632
349521010451	Glucan 1,4-alpha-maltotetraohydrolase (alpha-MTH), C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Alpha-MTH, also known as maltotetraose-forming exo-amylase or G4-amylase, is an exo-amylase found in bacteria that degrades starch from...; Region: CBM20_alpha_MTH; cd05810
349521010452	starch-binding site 2 [chemical binding]; other site
349521010453	starch-binding site 1 [chemical binding]; other site
349521010454	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
349521010455	Anti-sigma-K factor rskA; Region: RskA; pfam10099
349521010456	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
349521010457	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349521010458	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521010459	DNA binding residues [nucleotide binding]
349521010460	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
349521010461	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
349521010462	Pectinacetylesterase; Region: PAE; pfam03283
349521010463	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521010464	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521010465	substrate binding pocket [chemical binding]; other site
349521010466	membrane-bound complex binding site; other site
349521010467	hinge residues; other site
349521010468	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521010469	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
349521010470	ATP binding site [chemical binding]; other site
349521010471	putative Mg++ binding site [ion binding]; other site
349521010472	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521010473	nucleotide binding region [chemical binding]; other site
349521010474	ATP-binding site [chemical binding]; other site
349521010475	DEAD/H associated; Region: DEAD_assoc; pfam08494
349521010476	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
349521010477	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
349521010478	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521010479	DNA-binding site [nucleotide binding]; DNA binding site
349521010480	UTRA domain; Region: UTRA; pfam07702
349521010481	imidazolonepropionase; Validated; Region: PRK09356
349521010482	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
349521010483	active site
349521010484	formimidoylglutamase; Provisional; Region: PRK13775
349521010485	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
349521010486	putative active site [active]
349521010487	putative metal binding site [ion binding]; other site
349521010488	urocanate hydratase; Provisional; Region: PRK05414
349521010489	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
349521010490	active sites [active]
349521010491	tetramer interface [polypeptide binding]; other site
349521010492	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521010493	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521010494	substrate binding pocket [chemical binding]; other site
349521010495	membrane-bound complex binding site; other site
349521010496	hinge residues; other site
349521010497	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521010498	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521010499	substrate binding pocket [chemical binding]; other site
349521010500	membrane-bound complex binding site; other site
349521010501	hinge residues; other site
349521010502	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349521010503	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
349521010504	Sel1-like repeats; Region: SEL1; smart00671
349521010505	Sel1-like repeats; Region: SEL1; smart00671
349521010506	Sel1-like repeats; Region: SEL1; smart00671
349521010507	Sel1-like repeats; Region: SEL1; smart00671
349521010508	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
349521010509	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521010510	dimerization interface [polypeptide binding]; other site
349521010511	putative DNA binding site [nucleotide binding]; other site
349521010512	putative Zn2+ binding site [ion binding]; other site
349521010513	Putative phosphatase (DUF442); Region: DUF442; cl17385
349521010514	Predicted permeases [General function prediction only]; Region: COG0730
349521010515	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
349521010516	active site
349521010517	Zn binding site [ion binding]; other site
349521010518	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
349521010519	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
349521010520	DJ-1 family protein; Region: not_thiJ; TIGR01383
349521010521	conserved cys residue [active]
349521010522	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349521010523	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
349521010524	conserved cys residue [active]
349521010525	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521010526	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
349521010527	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
349521010528	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
349521010529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
349521010530	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
349521010531	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349521010532	Autotransporter beta-domain; Region: Autotransporter; smart00869
349521010533	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
349521010534	metal ion-dependent adhesion site (MIDAS); other site
349521010535	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
349521010536	Prostaglandin dehydrogenases; Region: PGDH; cd05288
349521010537	NAD(P) binding site [chemical binding]; other site
349521010538	substrate binding site [chemical binding]; other site
349521010539	dimer interface [polypeptide binding]; other site
349521010540	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521010541	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521010542	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521010543	putative effector binding pocket; other site
349521010544	dimerization interface [polypeptide binding]; other site
349521010545	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
349521010546	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349521010547	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
349521010548	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349521010549	putative acyl-acceptor binding pocket; other site
349521010550	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
349521010551	Putative phosphatase (DUF442); Region: DUF442; cl17385
349521010552	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521010553	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521010554	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521010555	Coenzyme A binding pocket [chemical binding]; other site
349521010556	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
349521010557	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349521010558	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
349521010559	YHYH protein; Region: YHYH; pfam14240
349521010560	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521010561	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521010562	Methyltransferase domain; Region: Methyltransf_12; pfam08242
349521010563	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
349521010564	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521010565	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
349521010566	catalytic residues [active]
349521010567	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521010568	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
349521010569	putative substrate translocation pore; other site
349521010570	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
349521010571	heme-binding site [chemical binding]; other site
349521010572	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521010573	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521010574	dimer interface [polypeptide binding]; other site
349521010575	phosphorylation site [posttranslational modification]
349521010576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010577	ATP binding site [chemical binding]; other site
349521010578	Mg2+ binding site [ion binding]; other site
349521010579	G-X-G motif; other site
349521010580	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
349521010581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521010582	Walker A motif; other site
349521010583	ATP binding site [chemical binding]; other site
349521010584	Walker B motif; other site
349521010585	arginine finger; other site
349521010586	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
349521010587	Response regulator receiver domain; Region: Response_reg; pfam00072
349521010588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010589	active site
349521010590	phosphorylation site [posttranslational modification]
349521010591	intermolecular recognition site; other site
349521010592	dimerization interface [polypeptide binding]; other site
349521010593	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521010594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010595	active site
349521010596	phosphorylation site [posttranslational modification]
349521010597	intermolecular recognition site; other site
349521010598	dimerization interface [polypeptide binding]; other site
349521010599	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521010600	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521010601	metal binding site [ion binding]; metal-binding site
349521010602	active site
349521010603	I-site; other site
349521010604	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521010605	PAS domain S-box; Region: sensory_box; TIGR00229
349521010606	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521010607	putative active site [active]
349521010608	heme pocket [chemical binding]; other site
349521010609	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521010610	PAS fold; Region: PAS_3; pfam08447
349521010611	putative active site [active]
349521010612	heme pocket [chemical binding]; other site
349521010613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521010614	dimer interface [polypeptide binding]; other site
349521010615	phosphorylation site [posttranslational modification]
349521010616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010617	ATP binding site [chemical binding]; other site
349521010618	Mg2+ binding site [ion binding]; other site
349521010619	G-X-G motif; other site
349521010620	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
349521010621	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
349521010622	Autotransporter beta-domain; Region: Autotransporter; smart00869
349521010623	CHASE domain; Region: CHASE; pfam03924
349521010624	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521010625	PAS fold; Region: PAS_3; pfam08447
349521010626	putative active site [active]
349521010627	heme pocket [chemical binding]; other site
349521010628	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521010629	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349521010630	putative active site [active]
349521010631	heme pocket [chemical binding]; other site
349521010632	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521010633	dimer interface [polypeptide binding]; other site
349521010634	phosphorylation site [posttranslational modification]
349521010635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010636	ATP binding site [chemical binding]; other site
349521010637	Mg2+ binding site [ion binding]; other site
349521010638	G-X-G motif; other site
349521010639	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349521010640	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521010641	active site
349521010642	ATP binding site [chemical binding]; other site
349521010643	substrate binding site [chemical binding]; other site
349521010644	activation loop (A-loop); other site
349521010645	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
349521010646	Sel1-like repeats; Region: SEL1; smart00671
349521010647	Sel1-like repeats; Region: SEL1; smart00671
349521010648	Caspase domain; Region: Peptidase_C14; pfam00656
349521010649	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
349521010650	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
349521010651	Protein of unknown function (DUF770); Region: DUF770; pfam05591
349521010652	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
349521010653	Protein of unknown function (DUF877); Region: DUF877; pfam05943
349521010654	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
349521010655	Protein of unknown function (DUF877); Region: DUF877; pfam05943
349521010656	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
349521010657	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
349521010658	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
349521010659	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
349521010660	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
349521010661	Clp amino terminal domain; Region: Clp_N; pfam02861
349521010662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521010663	Walker A motif; other site
349521010664	ATP binding site [chemical binding]; other site
349521010665	Walker B motif; other site
349521010666	arginine finger; other site
349521010667	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521010668	Walker A motif; other site
349521010669	ATP binding site [chemical binding]; other site
349521010670	Walker B motif; other site
349521010671	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
349521010672	Transposase IS200 like; Region: Y1_Tnp; cl00848
349521010673	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521010674	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
349521010675	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521010676	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521010677	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521010678	putative effector binding pocket; other site
349521010679	dimerization interface [polypeptide binding]; other site
349521010680	Uncharacterized conserved protein [Function unknown]; Region: COG1359
349521010681	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
349521010682	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
349521010683	homotrimer interaction site [polypeptide binding]; other site
349521010684	putative active site [active]
349521010685	lipase chaperone; Provisional; Region: PRK01294
349521010686	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
349521010687	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
349521010688	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
349521010689	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
349521010690	Response regulator receiver domain; Region: Response_reg; pfam00072
349521010691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010692	active site
349521010693	phosphorylation site [posttranslational modification]
349521010694	intermolecular recognition site; other site
349521010695	dimerization interface [polypeptide binding]; other site
349521010696	Response regulator receiver domain; Region: Response_reg; pfam00072
349521010697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010698	active site
349521010699	phosphorylation site [posttranslational modification]
349521010700	intermolecular recognition site; other site
349521010701	dimerization interface [polypeptide binding]; other site
349521010702	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521010703	HAMP domain; Region: HAMP; pfam00672
349521010704	dimerization interface [polypeptide binding]; other site
349521010705	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521010706	dimer interface [polypeptide binding]; other site
349521010707	phosphorylation site [posttranslational modification]
349521010708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010709	ATP binding site [chemical binding]; other site
349521010710	Mg2+ binding site [ion binding]; other site
349521010711	G-X-G motif; other site
349521010712	Response regulator receiver domain; Region: Response_reg; pfam00072
349521010713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010714	active site
349521010715	phosphorylation site [posttranslational modification]
349521010716	intermolecular recognition site; other site
349521010717	dimerization interface [polypeptide binding]; other site
349521010718	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521010719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010720	active site
349521010721	phosphorylation site [posttranslational modification]
349521010722	intermolecular recognition site; other site
349521010723	dimerization interface [polypeptide binding]; other site
349521010724	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
349521010725	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
349521010726	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521010727	N-terminal plug; other site
349521010728	ligand-binding site [chemical binding]; other site
349521010729	Response regulator receiver domain; Region: Response_reg; pfam00072
349521010730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010731	active site
349521010732	phosphorylation site [posttranslational modification]
349521010733	intermolecular recognition site; other site
349521010734	dimerization interface [polypeptide binding]; other site
349521010735	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521010736	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521010737	metal binding site [ion binding]; metal-binding site
349521010738	active site
349521010739	I-site; other site
349521010740	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521010741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
349521010742	PAS fold; Region: PAS; pfam00989
349521010743	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
349521010744	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521010745	Walker B motif; other site
349521010746	arginine finger; other site
349521010747	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521010748	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
349521010749	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
349521010750	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
349521010751	DctM-like transporters; Region: DctM; pfam06808
349521010752	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
349521010753	Coenzyme A transferase; Region: CoA_trans; smart00882
349521010754	Coenzyme A transferase; Region: CoA_trans; cl17247
349521010755	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
349521010756	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349521010757	PYR/PP interface [polypeptide binding]; other site
349521010758	dimer interface [polypeptide binding]; other site
349521010759	TPP binding site [chemical binding]; other site
349521010760	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349521010761	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
349521010762	TPP-binding site; other site
349521010763	dimer interface [polypeptide binding]; other site
349521010764	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
349521010765	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
349521010766	conserved hypothetical protein; Region: TIGR02270
349521010767	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
349521010768	Protein of unknown function (DUF796); Region: DUF796; pfam05638
349521010769	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
349521010770	Protein phosphatase 2C; Region: PP2C; pfam00481
349521010771	active site
349521010772	type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373
349521010773	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
349521010774	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
349521010775	G1 box; other site
349521010776	GTP/Mg2+ binding site [chemical binding]; other site
349521010777	G2 box; other site
349521010778	G3 box; other site
349521010779	Switch II region; other site
349521010780	G4 box; other site
349521010781	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
349521010782	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
349521010783	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
349521010784	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
349521010785	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
349521010786	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
349521010787	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
349521010788	phosphopeptide binding site; other site
349521010789	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
349521010790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010791	Response regulator receiver domain; Region: Response_reg; pfam00072
349521010792	active site
349521010793	phosphorylation site [posttranslational modification]
349521010794	intermolecular recognition site; other site
349521010795	dimerization interface [polypeptide binding]; other site
349521010796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010797	Response regulator receiver domain; Region: Response_reg; pfam00072
349521010798	active site
349521010799	phosphorylation site [posttranslational modification]
349521010800	intermolecular recognition site; other site
349521010801	dimerization interface [polypeptide binding]; other site
349521010802	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521010803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010804	ATP binding site [chemical binding]; other site
349521010805	Mg2+ binding site [ion binding]; other site
349521010806	G-X-G motif; other site
349521010807	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
349521010808	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
349521010809	SEC-C motif; Region: SEC-C; pfam02810
349521010810	transcriptional regulator MalT; Provisional; Region: PRK04841
349521010811	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521010812	DNA binding residues [nucleotide binding]
349521010813	dimerization interface [polypeptide binding]; other site
349521010814	alpha-amylase; Provisional; Region: PLN00196
349521010815	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
349521010816	active site
349521010817	catalytic site [active]
349521010818	Domain of unknown function (DUF1921); Region: DUF1921; pfam09081
349521010819	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
349521010820	GSH binding site [chemical binding]; other site
349521010821	catalytic residues [active]
349521010822	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521010823	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521010824	ligand binding site [chemical binding]; other site
349521010825	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
349521010826	DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744
349521010827	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574
349521010828	active site
349521010829	active site
349521010830	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
349521010831	multidrug efflux protein NorA; Provisional; Region: PRK00187
349521010832	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
349521010833	cation binding site [ion binding]; other site
349521010834	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
349521010835	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521010836	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
349521010837	dimerization interface [polypeptide binding]; other site
349521010838	substrate binding pocket [chemical binding]; other site
349521010839	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
349521010840	active site
349521010841	DNA polymerase IV; Validated; Region: PRK02406
349521010842	DNA binding site [nucleotide binding]
349521010843	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
349521010844	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521010845	dimerization interface [polypeptide binding]; other site
349521010846	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521010847	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521010848	dimer interface [polypeptide binding]; other site
349521010849	putative CheW interface [polypeptide binding]; other site
349521010850	NADH kinase; Region: PLN02929
349521010851	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cd02106
349521010852	Domain of unknown function (DUF3523); Region: DUF3523; pfam12037
349521010853	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521010854	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521010855	substrate binding pocket [chemical binding]; other site
349521010856	membrane-bound complex binding site; other site
349521010857	hinge residues; other site
349521010858	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521010859	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521010860	substrate binding pocket [chemical binding]; other site
349521010861	membrane-bound complex binding site; other site
349521010862	hinge residues; other site
349521010863	Uncharacterized conserved protein [Function unknown]; Region: COG3791
349521010864	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521010865	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521010866	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521010867	dimer interface [polypeptide binding]; other site
349521010868	phosphorylation site [posttranslational modification]
349521010869	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010870	ATP binding site [chemical binding]; other site
349521010871	Mg2+ binding site [ion binding]; other site
349521010872	G-X-G motif; other site
349521010873	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
349521010874	catalytic triad [active]
349521010875	conserved cis-peptide bond; other site
349521010876	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521010877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010878	active site
349521010879	phosphorylation site [posttranslational modification]
349521010880	intermolecular recognition site; other site
349521010881	dimerization interface [polypeptide binding]; other site
349521010882	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521010883	DNA binding site [nucleotide binding]
349521010884	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
349521010885	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
349521010886	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
349521010887	Protein of unknown function DUF99; Region: DUF99; pfam01949
349521010888	hypothetical protein; Provisional; Region: PRK00766
349521010889	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
349521010890	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349521010891	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521010892	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521010893	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521010894	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521010895	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
349521010896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521010897	S-adenosylmethionine binding site [chemical binding]; other site
349521010898	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
349521010899	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
349521010900	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
349521010901	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
349521010902	NAD(P) binding site [chemical binding]; other site
349521010903	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
349521010904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521010905	active site
349521010906	phosphorylation site [posttranslational modification]
349521010907	intermolecular recognition site; other site
349521010908	dimerization interface [polypeptide binding]; other site
349521010909	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521010910	DNA binding site [nucleotide binding]
349521010911	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
349521010912	proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785
349521010913	putative ligand binding site [chemical binding]; other site
349521010914	HAMP domain; Region: HAMP; pfam00672
349521010915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521010916	dimer interface [polypeptide binding]; other site
349521010917	phosphorylation site [posttranslational modification]
349521010918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521010919	ATP binding site [chemical binding]; other site
349521010920	Mg2+ binding site [ion binding]; other site
349521010921	G-X-G motif; other site
349521010922	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
349521010923	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
349521010924	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
349521010925	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
349521010926	active site
349521010927	putative substrate binding pocket [chemical binding]; other site
349521010928	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
349521010929	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521010930	S-adenosylmethionine binding site [chemical binding]; other site
349521010931	phosphoglycolate phosphatase; Provisional; Region: PRK13222
349521010932	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521010933	active site
349521010934	motif I; other site
349521010935	motif II; other site
349521010936	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521010937	NAD(P) binding site [chemical binding]; other site
349521010938	active site
349521010939	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
349521010940	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
349521010941	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
349521010942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521010943	binding surface
349521010944	TPR motif; other site
349521010945	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
349521010946	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
349521010947	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
349521010948	catalytic residues [active]
349521010949	central insert; other site
349521010950	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
349521010951	CcmE; Region: CcmE; pfam03100
349521010952	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
349521010953	heme exporter protein CcmC; Region: ccmC; TIGR01191
349521010954	heme exporter protein CcmB; Region: ccmB; TIGR01190
349521010955	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
349521010956	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521010957	Walker A/P-loop; other site
349521010958	ATP binding site [chemical binding]; other site
349521010959	Q-loop/lid; other site
349521010960	ABC transporter signature motif; other site
349521010961	Walker B; other site
349521010962	D-loop; other site
349521010963	H-loop/switch region; other site
349521010964	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
349521010965	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
349521010966	Protein of unknown function (DUF1244); Region: DUF1244; pfam06844
349521010967	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
349521010968	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
349521010969	dimerization interface [polypeptide binding]; other site
349521010970	DPS ferroxidase diiron center [ion binding]; other site
349521010971	ion pore; other site
349521010972	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
349521010973	Mechanosensitive ion channel; Region: MS_channel; pfam00924
349521010974	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521010975	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521010976	substrate binding pocket [chemical binding]; other site
349521010977	membrane-bound complex binding site; other site
349521010978	hinge residues; other site
349521010979	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
349521010980	BON domain; Region: BON; pfam04972
349521010981	BON domain; Region: BON; pfam04972
349521010982	Peptidase M15; Region: Peptidase_M15_3; cl01194
349521010983	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
349521010984	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
349521010985	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349521010986	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
349521010987	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
349521010988	putative active site [active]
349521010989	putative metal binding site [ion binding]; other site
349521010990	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
349521010991	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
349521010992	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
349521010993	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
349521010994	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
349521010995	FAD binding pocket [chemical binding]; other site
349521010996	FAD binding motif [chemical binding]; other site
349521010997	phosphate binding motif [ion binding]; other site
349521010998	beta-alpha-beta structure motif; other site
349521010999	NAD binding pocket [chemical binding]; other site
349521011000	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
349521011001	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521011002	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
349521011003	putative dimerization interface [polypeptide binding]; other site
349521011004	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521011005	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521011006	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
349521011007	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521011008	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521011009	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
349521011010	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
349521011011	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349521011012	Homeodomain-like domain; Region: HTH_32; pfam13565
349521011013	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
349521011014	PIN domain; Region: PIN; pfam01850
349521011015	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349521011016	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
349521011017	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
349521011018	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521011019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521011020	Walker A/P-loop; other site
349521011021	ATP binding site [chemical binding]; other site
349521011022	Q-loop/lid; other site
349521011023	ABC transporter signature motif; other site
349521011024	Walker B; other site
349521011025	D-loop; other site
349521011026	H-loop/switch region; other site
349521011027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
349521011028	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
349521011029	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
349521011030	homodimer interface [polypeptide binding]; other site
349521011031	substrate-cofactor binding pocket; other site
349521011032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521011033	catalytic residue [active]
349521011034	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
349521011035	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
349521011036	metal ion-dependent adhesion site (MIDAS); other site
349521011037	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
349521011038	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
349521011039	Low-spin heme binding site [chemical binding]; other site
349521011040	Putative water exit pathway; other site
349521011041	Binuclear center (active site) [active]
349521011042	K-pathway; other site
349521011043	Putative proton exit pathway; other site
349521011044	Cytochrome c; Region: Cytochrom_C; pfam00034
349521011045	MoxR-like ATPases [General function prediction only]; Region: COG0714
349521011046	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521011047	Walker A motif; other site
349521011048	ATP binding site [chemical binding]; other site
349521011049	Walker B motif; other site
349521011050	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
349521011051	Cytochrome c553 [Energy production and conversion]; Region: COG2863
349521011052	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349521011053	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
349521011054	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
349521011055	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349521011056	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
349521011057	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521011058	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
349521011059	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521011060	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521011061	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521011062	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
349521011063	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521011064	FeS/SAM binding site; other site
349521011065	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
349521011066	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
349521011067	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349521011068	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
349521011069	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
349521011070	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
349521011071	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
349521011072	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
349521011073	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521011074	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
349521011075	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
349521011076	active site
349521011077	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
349521011078	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521011079	active site
349521011080	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
349521011081	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521011082	Class I aldolases; Region: Aldolase_Class_I; cl17187
349521011083	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582
349521011084	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
349521011085	active site
349521011086	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
349521011087	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
349521011088	putative sugar binding sites [chemical binding]; other site
349521011089	Q-X-W motif; other site
349521011090	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_3; pfam13582
349521011091	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
349521011092	active site
349521011093	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
349521011094	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
349521011095	putative sugar binding sites [chemical binding]; other site
349521011096	Q-X-W motif; other site
349521011097	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521011098	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
349521011099	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
349521011100	active site
349521011101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521011102	PAS domain; Region: PAS_9; pfam13426
349521011103	putative active site [active]
349521011104	heme pocket [chemical binding]; other site
349521011105	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521011106	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521011107	metal binding site [ion binding]; metal-binding site
349521011108	active site
349521011109	I-site; other site
349521011110	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521011111	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
349521011112	propionate/acetate kinase; Provisional; Region: PRK12379
349521011113	phosphate acetyltransferase; Reviewed; Region: PRK05632
349521011114	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349521011115	DRTGG domain; Region: DRTGG; pfam07085
349521011116	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
349521011117	GTP-binding protein Der; Reviewed; Region: PRK00093
349521011118	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
349521011119	G1 box; other site
349521011120	GTP/Mg2+ binding site [chemical binding]; other site
349521011121	Switch I region; other site
349521011122	G2 box; other site
349521011123	Switch II region; other site
349521011124	G3 box; other site
349521011125	G4 box; other site
349521011126	G5 box; other site
349521011127	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
349521011128	G1 box; other site
349521011129	GTP/Mg2+ binding site [chemical binding]; other site
349521011130	Switch I region; other site
349521011131	G2 box; other site
349521011132	G3 box; other site
349521011133	Switch II region; other site
349521011134	G4 box; other site
349521011135	G5 box; other site
349521011136	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
349521011137	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
349521011138	Trp docking motif [polypeptide binding]; other site
349521011139	active site
349521011140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
349521011141	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
349521011142	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
349521011143	dimer interface [polypeptide binding]; other site
349521011144	motif 1; other site
349521011145	active site
349521011146	motif 2; other site
349521011147	motif 3; other site
349521011148	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
349521011149	anticodon binding site; other site
349521011150	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
349521011151	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
349521011152	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
349521011153	cytoskeletal protein RodZ; Provisional; Region: PRK10856
349521011154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521011155	non-specific DNA binding site [nucleotide binding]; other site
349521011156	salt bridge; other site
349521011157	sequence-specific DNA binding site [nucleotide binding]; other site
349521011158	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
349521011159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521011160	TPR motif; other site
349521011161	binding surface
349521011162	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
349521011163	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521011164	FeS/SAM binding site; other site
349521011165	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
349521011166	active site
349521011167	multimer interface [polypeptide binding]; other site
349521011168	cysteine desulfurase; Provisional; Region: PRK14012
349521011169	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
349521011170	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521011171	catalytic residue [active]
349521011172	Transcriptional regulator; Region: Rrf2; cl17282
349521011173	Rrf2 family protein; Region: rrf2_super; TIGR00738
349521011174	serine O-acetyltransferase; Region: cysE; TIGR01172
349521011175	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
349521011176	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
349521011177	trimer interface [polypeptide binding]; other site
349521011178	active site
349521011179	substrate binding site [chemical binding]; other site
349521011180	CoA binding site [chemical binding]; other site
349521011181	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
349521011182	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
349521011183	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349521011184	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
349521011185	active site
349521011186	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
349521011187	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
349521011188	Protein export membrane protein; Region: SecD_SecF; pfam02355
349521011189	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
349521011190	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
349521011191	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
349521011192	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
349521011193	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
349521011194	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
349521011195	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
349521011196	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
349521011197	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
349521011198	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
349521011199	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
349521011200	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
349521011201	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
349521011202	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349521011203	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349521011204	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
349521011205	Rod binding protein; Region: Rod-binding; cl01626
349521011206	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
349521011207	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
349521011208	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
349521011209	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
349521011210	Flagellar L-ring protein; Region: FlgH; pfam02107
349521011211	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
349521011212	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349521011213	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349521011214	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
349521011215	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349521011216	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
349521011217	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349521011218	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
349521011219	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
349521011220	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349521011221	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
349521011222	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
349521011223	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
349521011224	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
349521011225	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349521011226	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349521011227	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
349521011228	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
349521011229	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
349521011230	putative FMN binding site [chemical binding]; other site
349521011231	MASE2 domain; Region: MASE2; pfam05230
349521011232	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
349521011233	cyclase homology domain; Region: CHD; cd07302
349521011234	nucleotidyl binding site; other site
349521011235	metal binding site [ion binding]; metal-binding site
349521011236	dimer interface [polypeptide binding]; other site
349521011237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521011238	putative substrate translocation pore; other site
349521011239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521011240	7-cyano-7-deazaguanine reductase; Region: QueF; TIGR03138
349521011241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
349521011242	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
349521011243	inner membrane transport permease; Provisional; Region: PRK15066
349521011244	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
349521011245	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
349521011246	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349521011247	Walker A/P-loop; other site
349521011248	ATP binding site [chemical binding]; other site
349521011249	Q-loop/lid; other site
349521011250	ABC transporter signature motif; other site
349521011251	Walker B; other site
349521011252	D-loop; other site
349521011253	H-loop/switch region; other site
349521011254	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451
349521011255	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
349521011256	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
349521011257	HD domain; Region: HD_5; pfam13487
349521011258	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
349521011259	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
349521011260	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
349521011261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521011262	dimer interface [polypeptide binding]; other site
349521011263	conserved gate region; other site
349521011264	putative PBP binding loops; other site
349521011265	ABC-ATPase subunit interface; other site
349521011266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521011267	dimer interface [polypeptide binding]; other site
349521011268	conserved gate region; other site
349521011269	putative PBP binding loops; other site
349521011270	ABC-ATPase subunit interface; other site
349521011271	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
349521011272	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
349521011273	acyl-activating enzyme (AAE) consensus motif; other site
349521011274	putative AMP binding site [chemical binding]; other site
349521011275	putative active site [active]
349521011276	putative CoA binding site [chemical binding]; other site
349521011277	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
349521011278	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349521011279	zinc binding site [ion binding]; other site
349521011280	putative ligand binding site [chemical binding]; other site
349521011281	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349521011282	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
349521011283	TM-ABC transporter signature motif; other site
349521011284	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
349521011285	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521011286	Walker A/P-loop; other site
349521011287	ATP binding site [chemical binding]; other site
349521011288	Q-loop/lid; other site
349521011289	ABC transporter signature motif; other site
349521011290	Walker B; other site
349521011291	D-loop; other site
349521011292	H-loop/switch region; other site
349521011293	FIST N domain; Region: FIST; pfam08495
349521011294	Uncharacterized conserved protein [Function unknown]; Region: COG3287
349521011295	FIST C domain; Region: FIST_C; pfam10442
349521011296	PAS fold; Region: PAS_7; pfam12860
349521011297	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521011298	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521011299	metal binding site [ion binding]; metal-binding site
349521011300	active site
349521011301	I-site; other site
349521011302	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521011303	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
349521011304	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
349521011305	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521011306	catalytic residue [active]
349521011307	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
349521011308	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
349521011309	active site residue [active]
349521011310	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
349521011311	active site residue [active]
349521011312	H-NS histone family; Region: Histone_HNS; pfam00816
349521011313	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
349521011314	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
349521011315	Walker A/P-loop; other site
349521011316	ATP binding site [chemical binding]; other site
349521011317	Q-loop/lid; other site
349521011318	ABC transporter signature motif; other site
349521011319	Walker B; other site
349521011320	D-loop; other site
349521011321	H-loop/switch region; other site
349521011322	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
349521011323	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
349521011324	Walker A/P-loop; other site
349521011325	ATP binding site [chemical binding]; other site
349521011326	Q-loop/lid; other site
349521011327	ABC transporter signature motif; other site
349521011328	Walker B; other site
349521011329	D-loop; other site
349521011330	H-loop/switch region; other site
349521011331	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
349521011332	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
349521011333	TM-ABC transporter signature motif; other site
349521011334	HEAT repeats; Region: HEAT_2; pfam13646
349521011335	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
349521011336	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
349521011337	TM-ABC transporter signature motif; other site
349521011338	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349521011339	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
349521011340	putative ligand binding site [chemical binding]; other site
349521011341	UreD urease accessory protein; Region: UreD; pfam01774
349521011342	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
349521011343	alpha-gamma subunit interface [polypeptide binding]; other site
349521011344	beta-gamma subunit interface [polypeptide binding]; other site
349521011345	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
349521011346	gamma-beta subunit interface [polypeptide binding]; other site
349521011347	alpha-beta subunit interface [polypeptide binding]; other site
349521011348	urease subunit alpha; Reviewed; Region: ureC; PRK13207
349521011349	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
349521011350	subunit interactions [polypeptide binding]; other site
349521011351	active site
349521011352	flap region; other site
349521011353	urease accessory protein UreE; Provisional; Region: PRK14113
349521011354	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
349521011355	dimer interface [polypeptide binding]; other site
349521011356	catalytic residues [active]
349521011357	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
349521011358	UreF; Region: UreF; pfam01730
349521011359	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349521011360	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
349521011361	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
349521011362	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
349521011363	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
349521011364	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
349521011365	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
349521011366	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
349521011367	catalytic triad [active]
349521011368	Acylphosphatase; Region: Acylphosphatase; pfam00708
349521011369	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
349521011370	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
349521011371	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
349521011372	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
349521011373	oligomerization interface [polypeptide binding]; other site
349521011374	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
349521011375	Phage capsid family; Region: Phage_capsid; pfam05065
349521011376	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
349521011377	Phage-related protein [Function unknown]; Region: COG4695
349521011378	Phage portal protein; Region: Phage_portal; pfam04860
349521011379	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
349521011380	Phage terminase, small subunit; Region: Terminase_4; pfam05119
349521011381	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
349521011382	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
349521011383	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
349521011384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521011385	Coenzyme A binding pocket [chemical binding]; other site
349521011386	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
349521011387	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
349521011388	active site
349521011389	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
349521011390	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
349521011391	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
349521011392	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
349521011393	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349521011394	putative active site [active]
349521011395	putative NTP binding site [chemical binding]; other site
349521011396	putative nucleic acid binding site [nucleotide binding]; other site
349521011397	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
349521011398	Probable zinc-binding domain; Region: zf-trcl; pfam13451
349521011399	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349521011400	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521011401	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
349521011402	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521011403	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349521011404	active site
349521011405	DNA binding site [nucleotide binding]
349521011406	Int/Topo IB signature motif; other site
349521011407	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
349521011408	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
349521011409	DNA binding residues [nucleotide binding]
349521011410	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349521011411	IHF dimer interface [polypeptide binding]; other site
349521011412	IHF - DNA interface [nucleotide binding]; other site
349521011413	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
349521011414	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
349521011415	putative tRNA-binding site [nucleotide binding]; other site
349521011416	B3/4 domain; Region: B3_4; pfam03483
349521011417	tRNA synthetase B5 domain; Region: B5; smart00874
349521011418	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
349521011419	dimer interface [polypeptide binding]; other site
349521011420	motif 1; other site
349521011421	motif 3; other site
349521011422	motif 2; other site
349521011423	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
349521011424	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
349521011425	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
349521011426	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
349521011427	dimer interface [polypeptide binding]; other site
349521011428	motif 1; other site
349521011429	active site
349521011430	motif 2; other site
349521011431	motif 3; other site
349521011432	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
349521011433	23S rRNA binding site [nucleotide binding]; other site
349521011434	L21 binding site [polypeptide binding]; other site
349521011435	L13 binding site [polypeptide binding]; other site
349521011436	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
349521011437	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
349521011438	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
349521011439	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
349521011440	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
349521011441	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
349521011442	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
349521011443	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
349521011444	active site
349521011445	dimer interface [polypeptide binding]; other site
349521011446	motif 1; other site
349521011447	motif 2; other site
349521011448	motif 3; other site
349521011449	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
349521011450	anticodon binding site; other site
349521011451	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349521011452	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349521011453	P-loop; other site
349521011454	Magnesium ion binding site [ion binding]; other site
349521011455	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349521011456	Magnesium ion binding site [ion binding]; other site
349521011457	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
349521011458	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521011459	membrane-bound complex binding site; other site
349521011460	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
349521011461	Protein export membrane protein; Region: SecD_SecF; cl14618
349521011462	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
349521011463	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
349521011464	aminopeptidase N; Provisional; Region: pepN; PRK14015
349521011465	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
349521011466	active site
349521011467	Zn binding site [ion binding]; other site
349521011468	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
349521011469	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
349521011470	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
349521011471	Rhomboid family; Region: Rhomboid; pfam01694
349521011472	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349521011473	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521011474	active site
349521011475	metal binding site [ion binding]; metal-binding site
349521011476	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
349521011477	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
349521011478	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
349521011479	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
349521011480	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
349521011481	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521011482	catalytic residue [active]
349521011483	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
349521011484	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
349521011485	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
349521011486	active site
349521011487	FMN binding site [chemical binding]; other site
349521011488	2,4-decadienoyl-CoA binding site; other site
349521011489	catalytic residue [active]
349521011490	4Fe-4S cluster binding site [ion binding]; other site
349521011491	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
349521011492	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349521011493	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349521011494	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521011495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521011496	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521011497	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
349521011498	dimer interface [polypeptide binding]; other site
349521011499	active site
349521011500	metal binding site [ion binding]; metal-binding site
349521011501	glutathione binding site [chemical binding]; other site
349521011502	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
349521011503	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
349521011504	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
349521011505	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
349521011506	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
349521011507	NAD binding site [chemical binding]; other site
349521011508	ATP-grasp domain; Region: ATP-grasp; pfam02222
349521011509	superoxide dismutase; Provisional; Region: PRK10543
349521011510	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
349521011511	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
349521011512	biofilm formation regulator HmsP; Provisional; Region: PRK11829
349521011513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521011514	metal binding site [ion binding]; metal-binding site
349521011515	active site
349521011516	I-site; other site
349521011517	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521011518	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
349521011519	Peptidase family M48; Region: Peptidase_M48; cl12018
349521011520	type II secretion system protein D; Region: type_II_gspD; TIGR02517
349521011521	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349521011522	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349521011523	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349521011524	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349521011525	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
349521011526	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
349521011527	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
349521011528	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
349521011529	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
349521011530	ring oligomerisation interface [polypeptide binding]; other site
349521011531	ATP/Mg binding site [chemical binding]; other site
349521011532	stacking interactions; other site
349521011533	hinge regions; other site
349521011534	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
349521011535	oligomerisation interface [polypeptide binding]; other site
349521011536	mobile loop; other site
349521011537	roof hairpin; other site
349521011538	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
349521011539	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
349521011540	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521011541	NAD(P) binding site [chemical binding]; other site
349521011542	active site
349521011543	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
349521011544	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
349521011545	active site
349521011546	DNA binding site [nucleotide binding]
349521011547	muropeptide transporter; Validated; Region: ampG; cl17669
349521011548	muropeptide transporter; Validated; Region: ampG; cl17669
349521011549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
349521011550	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
349521011551	Response regulator receiver domain; Region: Response_reg; pfam00072
349521011552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521011553	active site
349521011554	phosphorylation site [posttranslational modification]
349521011555	intermolecular recognition site; other site
349521011556	dimerization interface [polypeptide binding]; other site
349521011557	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521011558	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521011559	metal binding site [ion binding]; metal-binding site
349521011560	active site
349521011561	I-site; other site
349521011562	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
349521011563	uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779
349521011564	putative N- and C-terminal domain interface [polypeptide binding]; other site
349521011565	putative active site [active]
349521011566	MgATP binding site [chemical binding]; other site
349521011567	catalytic site [active]
349521011568	metal binding site [ion binding]; metal-binding site
349521011569	putative carbohydrate binding site [chemical binding]; other site
349521011570	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
349521011571	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
349521011572	FAD binding domain; Region: FAD_binding_4; pfam01565
349521011573	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349521011574	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521011575	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521011576	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521011577	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521011578	non-specific DNA binding site [nucleotide binding]; other site
349521011579	salt bridge; other site
349521011580	sequence-specific DNA binding site [nucleotide binding]; other site
349521011581	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
349521011582	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
349521011583	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
349521011584	CoA-transferase family III; Region: CoA_transf_3; pfam02515
349521011585	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349521011586	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521011587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521011588	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521011589	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521011590	metal binding site [ion binding]; metal-binding site
349521011591	active site
349521011592	I-site; other site
349521011593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521011594	S-adenosylmethionine binding site [chemical binding]; other site
349521011595	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349521011596	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521011597	ligand binding site [chemical binding]; other site
349521011598	flexible hinge region; other site
349521011599	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349521011600	putative switch regulator; other site
349521011601	non-specific DNA interactions [nucleotide binding]; other site
349521011602	DNA binding site [nucleotide binding]
349521011603	sequence specific DNA binding site [nucleotide binding]; other site
349521011604	putative cAMP binding site [chemical binding]; other site
349521011605	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
349521011606	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
349521011607	cyclase homology domain; Region: CHD; cd07302
349521011608	nucleotidyl binding site; other site
349521011609	metal binding site [ion binding]; metal-binding site
349521011610	dimer interface [polypeptide binding]; other site
349521011611	FecR protein; Region: FecR; pfam04773
349521011612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521011613	binding surface
349521011614	TPR motif; other site
349521011615	TPR repeat; Region: TPR_11; pfam13414
349521011616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521011617	binding surface
349521011618	TPR motif; other site
349521011619	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
349521011620	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
349521011621	Methyltransferase domain; Region: Methyltransf_32; pfam13679
349521011622	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
349521011623	TIGR02647 family protein; Region: DNA
349521011624	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
349521011625	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
349521011626	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521011627	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521011628	AlkA N-terminal domain; Region: AlkA_N; pfam06029
349521011629	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
349521011630	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349521011631	minor groove reading motif; other site
349521011632	helix-hairpin-helix signature motif; other site
349521011633	substrate binding pocket [chemical binding]; other site
349521011634	active site
349521011635	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
349521011636	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
349521011637	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
349521011638	DNA binding site [nucleotide binding]
349521011639	active site
349521011640	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521011641	EamA-like transporter family; Region: EamA; pfam00892
349521011642	EamA-like transporter family; Region: EamA; pfam00892
349521011643	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521011644	dimerization interface [polypeptide binding]; other site
349521011645	putative DNA binding site [nucleotide binding]; other site
349521011646	putative Zn2+ binding site [ion binding]; other site
349521011647	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
349521011648	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521011649	putative metal binding site [ion binding]; other site
349521011650	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
349521011651	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
349521011652	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
349521011653	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521011654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521011655	putative substrate translocation pore; other site
349521011656	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521011657	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521011658	dimer interface [polypeptide binding]; other site
349521011659	putative CheW interface [polypeptide binding]; other site
349521011660	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
349521011661	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
349521011662	HAMP domain; Region: HAMP; pfam00672
349521011663	dimerization interface [polypeptide binding]; other site
349521011664	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521011665	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521011666	dimer interface [polypeptide binding]; other site
349521011667	putative CheW interface [polypeptide binding]; other site
349521011668	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
349521011669	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349521011670	active site
349521011671	putative transporter; Provisional; Region: PRK11660
349521011672	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
349521011673	Sulfate transporter family; Region: Sulfate_transp; pfam00916
349521011674	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
349521011675	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
349521011676	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349521011677	Walker A/P-loop; other site
349521011678	ATP binding site [chemical binding]; other site
349521011679	Q-loop/lid; other site
349521011680	ABC transporter signature motif; other site
349521011681	Walker B; other site
349521011682	D-loop; other site
349521011683	H-loop/switch region; other site
349521011684	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
349521011685	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
349521011686	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
349521011687	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
349521011688	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
349521011689	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
349521011690	PEP-CTERM motif; Region: VPEP; pfam07589
349521011691	MASE1; Region: MASE1; pfam05231
349521011692	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
349521011693	PAS domain S-box; Region: sensory_box; TIGR00229
349521011694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521011695	putative active site [active]
349521011696	heme pocket [chemical binding]; other site
349521011697	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521011698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521011699	phosphorylation site [posttranslational modification]
349521011700	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521011701	ATP binding site [chemical binding]; other site
349521011702	Mg2+ binding site [ion binding]; other site
349521011703	G-X-G motif; other site
349521011704	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
349521011705	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349521011706	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521011707	active site
349521011708	ATP binding site [chemical binding]; other site
349521011709	substrate binding site [chemical binding]; other site
349521011710	activation loop (A-loop); other site
349521011711	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
349521011712	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
349521011713	Uncharacterized conserved protein [Function unknown]; Region: COG1262
349521011714	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
349521011715	plant-specific FAD-dependent oxidoreductase; Region: pln_FAD_oxido; TIGR01677
349521011716	FAD binding domain; Region: FAD_binding_4; pfam01565
349521011717	FAD-dependent oxidoreductase; Provisional; Region: PLN00107
349521011718	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
349521011719	Bacterial sugar transferase; Region: Bac_transf; pfam02397
349521011720	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
349521011721	Chain length determinant protein; Region: Wzz; pfam02706
349521011722	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
349521011723	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
349521011724	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349521011725	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
349521011726	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
349521011727	SLBB domain; Region: SLBB; pfam10531
349521011728	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
349521011729	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
349521011730	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
349521011731	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
349521011732	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
349521011733	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
349521011734	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
349521011735	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521011736	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
349521011737	putative ADP-binding pocket [chemical binding]; other site
349521011738	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
349521011739	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521011740	putative ADP-binding pocket [chemical binding]; other site
349521011741	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
349521011742	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
349521011743	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
349521011744	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349521011745	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
349521011746	active site
349521011747	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349521011748	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
349521011749	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
349521011750	Probable Catalytic site; other site
349521011751	metal-binding site
349521011752	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
349521011753	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
349521011754	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
349521011755	colanic acid exporter; Provisional; Region: PRK10459
349521011756	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349521011757	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
349521011758	active site
349521011759	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
349521011760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521011761	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
349521011762	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
349521011763	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
349521011764	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
349521011765	ATP binding site [chemical binding]; other site
349521011766	Mg++ binding site [ion binding]; other site
349521011767	motif III; other site
349521011768	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521011769	nucleotide binding region [chemical binding]; other site
349521011770	ATP-binding site [chemical binding]; other site
349521011771	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
349521011772	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
349521011773	ATP binding site [chemical binding]; other site
349521011774	Mg++ binding site [ion binding]; other site
349521011775	motif III; other site
349521011776	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521011777	nucleotide binding region [chemical binding]; other site
349521011778	ATP-binding site [chemical binding]; other site
349521011779	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
349521011780	putative RNA binding site [nucleotide binding]; other site
349521011781	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
349521011782	DNA-binding site [nucleotide binding]; DNA binding site
349521011783	RNA-binding motif; other site
349521011784	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521011785	binding surface
349521011786	TPR motif; other site
349521011787	Tetratrico peptide repeat; Region: TPR_5; pfam12688
349521011788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349521011789	binding surface
349521011790	TPR motif; other site
349521011791	Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413
349521011792	active site
349521011793	metal binding site [ion binding]; metal-binding site
349521011794	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
349521011795	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521011796	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
349521011797	putative dimerization interface [polypeptide binding]; other site
349521011798	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
349521011799	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
349521011800	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
349521011801	active site
349521011802	catalytic residues [active]
349521011803	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
349521011804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521011805	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
349521011806	Response regulator receiver domain; Region: Response_reg; pfam00072
349521011807	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521011808	active site
349521011809	phosphorylation site [posttranslational modification]
349521011810	intermolecular recognition site; other site
349521011811	dimerization interface [polypeptide binding]; other site
349521011812	SAF-like; Region: SAF_2; pfam13144
349521011813	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
349521011814	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
349521011815	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
349521011816	FlgN protein; Region: FlgN; pfam05130
349521011817	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
349521011818	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521011819	metal binding site [ion binding]; metal-binding site
349521011820	active site
349521011821	I-site; other site
349521011822	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
349521011823	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
349521011824	substrate binding site [chemical binding]; other site
349521011825	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
349521011826	Uncharacterized conserved protein [Function unknown]; Region: COG4121
349521011827	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349521011828	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
349521011829	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
349521011830	FOG: CBS domain [General function prediction only]; Region: COG0517
349521011831	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
349521011832	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
349521011833	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
349521011834	nucleotide binding pocket [chemical binding]; other site
349521011835	K-X-D-G motif; other site
349521011836	catalytic site [active]
349521011837	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
349521011838	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
349521011839	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
349521011840	Dimer interface [polypeptide binding]; other site
349521011841	BRCT sequence motif; other site
349521011842	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
349521011843	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
349521011844	FtsZ protein binding site [polypeptide binding]; other site
349521011845	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
349521011846	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
349521011847	Walker A/P-loop; other site
349521011848	ATP binding site [chemical binding]; other site
349521011849	Q-loop/lid; other site
349521011850	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
349521011851	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
349521011852	ABC transporter signature motif; other site
349521011853	Walker B; other site
349521011854	D-loop; other site
349521011855	H-loop/switch region; other site
349521011856	Transcriptional regulators [Transcription]; Region: GntR; COG1802
349521011857	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521011858	DNA-binding site [nucleotide binding]; DNA binding site
349521011859	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
349521011860	Fatty acid desaturase; Region: FA_desaturase; pfam00487
349521011861	Di-iron ligands [ion binding]; other site
349521011862	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521011863	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521011864	metal binding site [ion binding]; metal-binding site
349521011865	active site
349521011866	I-site; other site
349521011867	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
349521011868	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349521011869	RNA binding surface [nucleotide binding]; other site
349521011870	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
349521011871	probable active site [active]
349521011872	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
349521011873	ScpA/B protein; Region: ScpA_ScpB; cl00598
349521011874	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
349521011875	active site
349521011876	HIGH motif; other site
349521011877	dimer interface [polypeptide binding]; other site
349521011878	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349521011879	active site
349521011880	KMSKS motif; other site
349521011881	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
349521011882	CoA binding domain; Region: CoA_binding; smart00881
349521011883	CoA-ligase; Region: Ligase_CoA; pfam00549
349521011884	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
349521011885	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
349521011886	CoA-ligase; Region: Ligase_CoA; pfam00549
349521011887	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
349521011888	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
349521011889	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521011890	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349521011891	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
349521011892	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349521011893	E3 interaction surface; other site
349521011894	lipoyl attachment site [posttranslational modification]; other site
349521011895	e3 binding domain; Region: E3_binding; pfam02817
349521011896	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
349521011897	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
349521011898	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
349521011899	TPP-binding site [chemical binding]; other site
349521011900	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
349521011901	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
349521011902	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
349521011903	L-aspartate oxidase; Provisional; Region: PRK06175
349521011904	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675
349521011905	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
349521011906	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
349521011907	SdhC subunit interface [polypeptide binding]; other site
349521011908	proximal heme binding site [chemical binding]; other site
349521011909	cardiolipin binding site; other site
349521011910	Iron-sulfur protein interface; other site
349521011911	proximal quinone binding site [chemical binding]; other site
349521011912	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
349521011913	Iron-sulfur protein interface; other site
349521011914	proximal quinone binding site [chemical binding]; other site
349521011915	SdhD (CybS) interface [polypeptide binding]; other site
349521011916	proximal heme binding site [chemical binding]; other site
349521011917	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
349521011918	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
349521011919	dimer interface [polypeptide binding]; other site
349521011920	active site
349521011921	citrylCoA binding site [chemical binding]; other site
349521011922	NADH binding [chemical binding]; other site
349521011923	cationic pore residues; other site
349521011924	oxalacetate/citrate binding site [chemical binding]; other site
349521011925	coenzyme A binding site [chemical binding]; other site
349521011926	catalytic triad [active]
349521011927	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
349521011928	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349521011929	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
349521011930	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
349521011931	active site
349521011932	interdomain interaction site; other site
349521011933	putative metal-binding site [ion binding]; other site
349521011934	nucleotide binding site [chemical binding]; other site
349521011935	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
349521011936	domain I; other site
349521011937	DNA binding groove [nucleotide binding]
349521011938	phosphate binding site [ion binding]; other site
349521011939	domain II; other site
349521011940	domain III; other site
349521011941	nucleotide binding site [chemical binding]; other site
349521011942	catalytic site [active]
349521011943	domain IV; other site
349521011944	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
349521011945	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
349521011946	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
349521011947	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
349521011948	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
349521011949	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349521011950	dimer interface [polypeptide binding]; other site
349521011951	active site
349521011952	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
349521011953	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521011954	substrate binding site [chemical binding]; other site
349521011955	oxyanion hole (OAH) forming residues; other site
349521011956	trimer interface [polypeptide binding]; other site
349521011957	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
349521011958	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
349521011959	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
349521011960	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349521011961	Ligand Binding Site [chemical binding]; other site
349521011962	ABC transporter ATPase component; Reviewed; Region: PRK11147
349521011963	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521011964	Walker A/P-loop; other site
349521011965	ATP binding site [chemical binding]; other site
349521011966	Q-loop/lid; other site
349521011967	ABC transporter signature motif; other site
349521011968	Walker B; other site
349521011969	D-loop; other site
349521011970	H-loop/switch region; other site
349521011971	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521011972	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
349521011973	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
349521011974	MOSC domain; Region: MOSC; pfam03473
349521011975	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
349521011976	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521011977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521011978	active site
349521011979	phosphorylation site [posttranslational modification]
349521011980	intermolecular recognition site; other site
349521011981	dimerization interface [polypeptide binding]; other site
349521011982	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
349521011983	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521011984	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
349521011985	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
349521011986	putative active site [active]
349521011987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521011988	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
349521011989	NAD(P) binding site [chemical binding]; other site
349521011990	active site
349521011991	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521011992	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521011993	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349521011994	CoenzymeA binding site [chemical binding]; other site
349521011995	subunit interaction site [polypeptide binding]; other site
349521011996	PHB binding site; other site
349521011997	prolyl-tRNA synthetase; Provisional; Region: PRK09194
349521011998	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
349521011999	dimer interface [polypeptide binding]; other site
349521012000	motif 1; other site
349521012001	active site
349521012002	motif 2; other site
349521012003	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
349521012004	putative deacylase active site [active]
349521012005	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349521012006	active site
349521012007	motif 3; other site
349521012008	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
349521012009	anticodon binding site; other site
349521012010	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
349521012011	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349521012012	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349521012013	catalytic residue [active]
349521012014	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
349521012015	ADP-ribose binding site [chemical binding]; other site
349521012016	dimer interface [polypeptide binding]; other site
349521012017	active site
349521012018	nudix motif; other site
349521012019	metal binding site [ion binding]; metal-binding site
349521012020	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
349521012021	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
349521012022	putative lyase; Provisional; Region: PRK09687
349521012023	MoxR-like ATPases [General function prediction only]; Region: COG0714
349521012024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521012025	Walker A motif; other site
349521012026	ATP binding site [chemical binding]; other site
349521012027	Walker B motif; other site
349521012028	arginine finger; other site
349521012029	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
349521012030	Protein of unknown function DUF58; Region: DUF58; pfam01882
349521012031	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
349521012032	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
349521012033	metal ion-dependent adhesion site (MIDAS); other site
349521012034	von Willebrand factor type A domain; Region: VWA_2; pfam13519
349521012035	metal ion-dependent adhesion site (MIDAS); other site
349521012036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521012037	binding surface
349521012038	TPR motif; other site
349521012039	TPR repeat; Region: TPR_11; pfam13414
349521012040	Oxygen tolerance; Region: BatD; pfam13584
349521012041	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521012042	arginine decarboxylase; Provisional; Region: PRK05354
349521012043	Dodecin; Region: Dodecin; pfam07311
349521012044	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
349521012045	putative dimer interface [polypeptide binding]; other site
349521012046	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521012047	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
349521012048	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
349521012049	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569
349521012050	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
349521012051	active site
349521012052	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
349521012053	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
349521012054	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
349521012055	putative sugar binding sites [chemical binding]; other site
349521012056	Q-X-W motif; other site
349521012057	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
349521012058	putative metal binding site [ion binding]; other site
349521012059	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
349521012060	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
349521012061	active site
349521012062	catalytic residues [active]
349521012063	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
349521012064	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
349521012065	aromatic chitin/cellulose binding site residues [chemical binding]; other site
349521012066	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
349521012067	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
349521012068	active site
349521012069	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349521012070	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349521012071	DNA binding site [nucleotide binding]
349521012072	domain linker motif; other site
349521012073	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
349521012074	putative dimerization interface [polypeptide binding]; other site
349521012075	putative ligand binding site [chemical binding]; other site
349521012076	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
349521012077	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
349521012078	catalytic triad [active]
349521012079	hypothetical protein; Validated; Region: PRK02101
349521012080	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
349521012081	acetyl-CoA synthetase; Provisional; Region: PRK00174
349521012082	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
349521012083	active site
349521012084	CoA binding site [chemical binding]; other site
349521012085	acyl-activating enzyme (AAE) consensus motif; other site
349521012086	AMP binding site [chemical binding]; other site
349521012087	acetate binding site [chemical binding]; other site
349521012088	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521012089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521012090	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521012091	putative effector binding pocket; other site
349521012092	dimerization interface [polypeptide binding]; other site
349521012093	DoxX; Region: DoxX; pfam07681
349521012094	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
349521012095	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
349521012096	putative active site [active]
349521012097	metal binding site [ion binding]; metal-binding site
349521012098	Haemolysin-III related; Region: HlyIII; cl03831
349521012099	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
349521012100	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
349521012101	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521012102	dimerization interface [polypeptide binding]; other site
349521012103	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521012104	dimer interface [polypeptide binding]; other site
349521012105	putative CheW interface [polypeptide binding]; other site
349521012106	PilZ domain; Region: PilZ; pfam07238
349521012107	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521012108	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521012109	substrate binding pocket [chemical binding]; other site
349521012110	membrane-bound complex binding site; other site
349521012111	hinge residues; other site
349521012112	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521012113	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521012114	substrate binding pocket [chemical binding]; other site
349521012115	membrane-bound complex binding site; other site
349521012116	hinge residues; other site
349521012117	Protein of unknown function (DUF419); Region: DUF419; pfam04237
349521012118	Carboxylesterase family; Region: COesterase; pfam00135
349521012119	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
349521012120	substrate binding pocket [chemical binding]; other site
349521012121	catalytic triad [active]
349521012122	Putative exonuclease, RdgC; Region: RdgC; pfam04381
349521012123	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
349521012124	CoA binding domain; Region: CoA_binding_2; pfam13380
349521012125	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
349521012126	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
349521012127	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521012128	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521012129	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
349521012130	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
349521012131	putative active site [active]
349521012132	Zn binding site [ion binding]; other site
349521012133	flagellar protein FliS; Validated; Region: fliS; PRK05685
349521012134	flagellar capping protein; Provisional; Region: PRK12765
349521012135	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
349521012136	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
349521012137	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
349521012138	FlaG protein; Region: FlaG; pfam03646
349521012139	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
349521012140	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
349521012141	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
349521012142	flagellin; Reviewed; Region: PRK08869
349521012143	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
349521012144	flagellin; Reviewed; Region: PRK08869
349521012145	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
349521012146	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521012147	binding surface
349521012148	TPR motif; other site
349521012149	serine O-acetyltransferase; Region: cysE; TIGR01172
349521012150	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
349521012151	trimer interface [polypeptide binding]; other site
349521012152	active site
349521012153	substrate binding site [chemical binding]; other site
349521012154	CoA binding site [chemical binding]; other site
349521012155	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
349521012156	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
349521012157	substrate binding site [chemical binding]; other site
349521012158	glutamase interaction surface [polypeptide binding]; other site
349521012159	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
349521012160	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
349521012161	putative active site [active]
349521012162	oxyanion strand; other site
349521012163	catalytic triad [active]
349521012164	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
349521012165	Ligand Binding Site [chemical binding]; other site
349521012166	flagellin modification protein A; Provisional; Region: PRK09186
349521012167	classical (c) SDR, subgroup 8; Region: SDR_c8; cd08930
349521012168	putative NAD(P) binding site [chemical binding]; other site
349521012169	active site
349521012170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521012171	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
349521012172	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349521012173	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521012174	catalytic residue [active]
349521012175	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
349521012176	ligand binding site; other site
349521012177	tetramer interface; other site
349521012178	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
349521012179	FOG: CBS domain [General function prediction only]; Region: COG0517
349521012180	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
349521012181	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
349521012182	Substrate binding site; other site
349521012183	metal-binding site
349521012184	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
349521012185	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
349521012186	putative trimer interface [polypeptide binding]; other site
349521012187	putative CoA binding site [chemical binding]; other site
349521012188	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
349521012189	NeuB family; Region: NeuB; pfam03102
349521012190	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
349521012191	NeuB binding interface [polypeptide binding]; other site
349521012192	putative substrate binding site [chemical binding]; other site
349521012193	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
349521012194	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
349521012195	active site
349521012196	homodimer interface [polypeptide binding]; other site
349521012197	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
349521012198	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
349521012199	inhibitor-cofactor binding pocket; inhibition site
349521012200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521012201	catalytic residue [active]
349521012202	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
349521012203	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
349521012204	NAD binding site [chemical binding]; other site
349521012205	substrate binding site [chemical binding]; other site
349521012206	active site
349521012207	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
349521012208	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
349521012209	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
349521012210	Probable Catalytic site; other site
349521012211	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
349521012212	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521012213	FeS/SAM binding site; other site
349521012214	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
349521012215	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
349521012216	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521012217	Coenzyme A binding pocket [chemical binding]; other site
349521012218	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521012219	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
349521012220	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
349521012221	active site flap/lid [active]
349521012222	nucleophilic elbow; other site
349521012223	catalytic triad [active]
349521012224	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366
349521012225	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521012226	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521012227	putative DNA binding site [nucleotide binding]; other site
349521012228	putative Zn2+ binding site [ion binding]; other site
349521012229	AsnC family; Region: AsnC_trans_reg; pfam01037
349521012230	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521012231	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
349521012232	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
349521012233	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
349521012234	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521012235	active site
349521012236	metal binding site [ion binding]; metal-binding site
349521012237	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
349521012238	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521012239	dimer interface [polypeptide binding]; other site
349521012240	putative CheW interface [polypeptide binding]; other site
349521012241	PhoD-like phosphatase; Region: PhoD; pfam09423
349521012242	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
349521012243	putative active site [active]
349521012244	putative metal binding site [ion binding]; other site
349521012245	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349521012246	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
349521012247	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521012248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521012249	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521012250	dimerization interface [polypeptide binding]; other site
349521012251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521012252	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521012253	putative substrate translocation pore; other site
349521012254	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
349521012255	active site 1 [active]
349521012256	dimer interface [polypeptide binding]; other site
349521012257	hexamer interface [polypeptide binding]; other site
349521012258	active site 2 [active]
349521012259	Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226
349521012260	putative active site [active]
349521012261	Zn binding site [ion binding]; other site
349521012262	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
349521012263	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
349521012264	pseudo EF-hand loop; other site
349521012265	peptide binding pocket; other site
349521012266	Ca2+ binding site [ion binding]; other site
349521012267	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
349521012268	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521012269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521012270	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521012271	putative effector binding pocket; other site
349521012272	dimerization interface [polypeptide binding]; other site
349521012273	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
349521012274	putative ADP-ribose binding site [chemical binding]; other site
349521012275	putative active site [active]
349521012276	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521012277	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
349521012278	dimer interface [polypeptide binding]; other site
349521012279	putative metal binding site [ion binding]; other site
349521012280	putative oxidoreductase; Provisional; Region: PRK11579
349521012281	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349521012282	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
349521012283	Cache domain; Region: Cache_1; pfam02743
349521012284	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521012285	dimerization interface [polypeptide binding]; other site
349521012286	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521012287	dimer interface [polypeptide binding]; other site
349521012288	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
349521012289	putative CheW interface [polypeptide binding]; other site
349521012290	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
349521012291	substrate binding site [chemical binding]; other site
349521012292	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521012293	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521012294	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521012295	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521012296	substrate binding pocket [chemical binding]; other site
349521012297	membrane-bound complex binding site; other site
349521012298	hinge residues; other site
349521012299	MarC family integral membrane protein; Region: MarC; cl00919
349521012300	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349521012301	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
349521012302	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521012303	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521012304	active site
349521012305	ATP binding site [chemical binding]; other site
349521012306	substrate binding site [chemical binding]; other site
349521012307	activation loop (A-loop); other site
349521012308	RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6
349521012309	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521012310	DNA binding residues [nucleotide binding]
349521012311	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
349521012312	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
349521012313	acyl-activating enzyme (AAE) consensus motif; other site
349521012314	putative AMP binding site [chemical binding]; other site
349521012315	putative active site [active]
349521012316	putative CoA binding site [chemical binding]; other site
349521012317	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
349521012318	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521012319	putative active site [active]
349521012320	putative metal binding site [ion binding]; other site
349521012321	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
349521012322	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521012323	NAD(P) binding site [chemical binding]; other site
349521012324	active site
349521012325	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
349521012326	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
349521012327	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
349521012328	active site
349521012329	dimer interface [polypeptide binding]; other site
349521012330	effector binding site; other site
349521012331	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
349521012332	TSCPD domain; Region: TSCPD; pfam12637
349521012333	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
349521012334	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
349521012335	active site
349521012336	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
349521012337	tetramer interface; other site
349521012338	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521012339	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521012340	non-specific DNA binding site [nucleotide binding]; other site
349521012341	salt bridge; other site
349521012342	sequence-specific DNA binding site [nucleotide binding]; other site
349521012343	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
349521012344	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
349521012345	dimer interface [polypeptide binding]; other site
349521012346	putative functional site; other site
349521012347	putative MPT binding site; other site
349521012348	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
349521012349	MPT binding site; other site
349521012350	trimer interface [polypeptide binding]; other site
349521012351	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
349521012352	active site clefts [active]
349521012353	zinc binding site [ion binding]; other site
349521012354	dimer interface [polypeptide binding]; other site
349521012355	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349521012356	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
349521012357	putative NAD(P) binding site [chemical binding]; other site
349521012358	active site
349521012359	putative substrate binding site [chemical binding]; other site
349521012360	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
349521012361	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
349521012362	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
349521012363	ATP binding site [chemical binding]; other site
349521012364	active site
349521012365	substrate binding site [chemical binding]; other site
349521012366	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
349521012367	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
349521012368	dihydrodipicolinate synthase; Region: dapA; TIGR00674
349521012369	dimer interface [polypeptide binding]; other site
349521012370	active site
349521012371	catalytic residue [active]
349521012372	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
349521012373	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
349521012374	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
349521012375	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
349521012376	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
349521012377	catalytic triad [active]
349521012378	Domain of unknown function DUF20; Region: UPF0118; pfam01594
349521012379	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
349521012380	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
349521012381	CPxP  motif; other site
349521012382	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
349521012383	Peptidase family M48; Region: Peptidase_M48; pfam01435
349521012384	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521012385	binding surface
349521012386	TPR motif; other site
349521012387	quinolinate synthetase; Provisional; Region: PRK09375
349521012388	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
349521012389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521012390	binding surface
349521012391	TPR motif; other site
349521012392	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521012393	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521012394	ligand binding site [chemical binding]; other site
349521012395	translocation protein TolB; Provisional; Region: tolB; PRK00178
349521012396	TolB amino-terminal domain; Region: TolB_N; pfam04052
349521012397	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
349521012398	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
349521012399	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
349521012400	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
349521012401	TolA protein; Region: tolA_full; TIGR02794
349521012402	TonB C terminal; Region: TonB_2; pfam13103
349521012403	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
349521012404	TolR protein; Region: tolR; TIGR02801
349521012405	TolQ protein; Region: tolQ; TIGR02796
349521012406	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
349521012407	active site
349521012408	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
349521012409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521012410	Walker A motif; other site
349521012411	ATP binding site [chemical binding]; other site
349521012412	Walker B motif; other site
349521012413	arginine finger; other site
349521012414	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
349521012415	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
349521012416	RuvA N terminal domain; Region: RuvA_N; pfam01330
349521012417	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
349521012418	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
349521012419	active site
349521012420	putative DNA-binding cleft [nucleotide binding]; other site
349521012421	dimer interface [polypeptide binding]; other site
349521012422	hypothetical protein; Validated; Region: PRK00110
349521012423	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
349521012424	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
349521012425	dimer interface [polypeptide binding]; other site
349521012426	anticodon binding site; other site
349521012427	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
349521012428	homodimer interface [polypeptide binding]; other site
349521012429	motif 1; other site
349521012430	active site
349521012431	motif 2; other site
349521012432	GAD domain; Region: GAD; pfam02938
349521012433	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349521012434	active site
349521012435	motif 3; other site
349521012436	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
349521012437	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349521012438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012439	active site
349521012440	phosphorylation site [posttranslational modification]
349521012441	intermolecular recognition site; other site
349521012442	dimerization interface [polypeptide binding]; other site
349521012443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521012444	Walker A motif; other site
349521012445	ATP binding site [chemical binding]; other site
349521012446	Walker B motif; other site
349521012447	arginine finger; other site
349521012448	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521012449	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521012450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521012451	dimer interface [polypeptide binding]; other site
349521012452	phosphorylation site [posttranslational modification]
349521012453	CHASE3 domain; Region: CHASE3; pfam05227
349521012454	CD34/Podocalyxin family; Region: CD34_antigen; pfam06365
349521012455	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521012456	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521012457	dimer interface [polypeptide binding]; other site
349521012458	phosphorylation site [posttranslational modification]
349521012459	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521012460	ATP binding site [chemical binding]; other site
349521012461	Mg2+ binding site [ion binding]; other site
349521012462	G-X-G motif; other site
349521012463	Response regulator receiver domain; Region: Response_reg; pfam00072
349521012464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012465	active site
349521012466	phosphorylation site [posttranslational modification]
349521012467	intermolecular recognition site; other site
349521012468	dimerization interface [polypeptide binding]; other site
349521012469	Response regulator receiver domain; Region: Response_reg; pfam00072
349521012470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012471	active site
349521012472	phosphorylation site [posttranslational modification]
349521012473	intermolecular recognition site; other site
349521012474	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521012475	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521012476	dimer interface [polypeptide binding]; other site
349521012477	phosphorylation site [posttranslational modification]
349521012478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521012479	ATP binding site [chemical binding]; other site
349521012480	Mg2+ binding site [ion binding]; other site
349521012481	G-X-G motif; other site
349521012482	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521012483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012484	active site
349521012485	phosphorylation site [posttranslational modification]
349521012486	intermolecular recognition site; other site
349521012487	dimerization interface [polypeptide binding]; other site
349521012488	Response regulator receiver domain; Region: Response_reg; pfam00072
349521012489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012490	active site
349521012491	phosphorylation site [posttranslational modification]
349521012492	intermolecular recognition site; other site
349521012493	dimerization interface [polypeptide binding]; other site
349521012494	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
349521012495	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521012496	Zn2+ binding site [ion binding]; other site
349521012497	Mg2+ binding site [ion binding]; other site
349521012498	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
349521012499	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521012500	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
349521012501	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
349521012502	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
349521012503	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
349521012504	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
349521012505	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
349521012506	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
349521012507	NAD binding site [chemical binding]; other site
349521012508	homodimer interface [polypeptide binding]; other site
349521012509	active site
349521012510	substrate binding site [chemical binding]; other site
349521012511	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
349521012512	nucleoside/Zn binding site; other site
349521012513	dimer interface [polypeptide binding]; other site
349521012514	catalytic motif [active]
349521012515	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
349521012516	GMP synthase; Reviewed; Region: guaA; PRK00074
349521012517	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
349521012518	AMP/PPi binding site [chemical binding]; other site
349521012519	candidate oxyanion hole; other site
349521012520	catalytic triad [active]
349521012521	potential glutamine specificity residues [chemical binding]; other site
349521012522	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
349521012523	ATP Binding subdomain [chemical binding]; other site
349521012524	Ligand Binding sites [chemical binding]; other site
349521012525	Dimerization subdomain; other site
349521012526	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
349521012527	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
349521012528	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
349521012529	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
349521012530	active site
349521012531	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
349521012532	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
349521012533	generic binding surface II; other site
349521012534	generic binding surface I; other site
349521012535	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349521012536	CoenzymeA binding site [chemical binding]; other site
349521012537	subunit interaction site [polypeptide binding]; other site
349521012538	PHB binding site; other site
349521012539	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349521012540	CoenzymeA binding site [chemical binding]; other site
349521012541	subunit interaction site [polypeptide binding]; other site
349521012542	PHB binding site; other site
349521012543	Protein of unknown function, DUF599; Region: DUF599; pfam04654
349521012544	Peptidase family M48; Region: Peptidase_M48; pfam01435
349521012545	TPR repeat; Region: TPR_11; pfam13414
349521012546	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521012547	binding surface
349521012548	TPR motif; other site
349521012549	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521012550	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
349521012551	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
349521012552	FtsX-like permease family; Region: FtsX; pfam02687
349521012553	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
349521012554	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349521012555	Walker A/P-loop; other site
349521012556	ATP binding site [chemical binding]; other site
349521012557	Q-loop/lid; other site
349521012558	ABC transporter signature motif; other site
349521012559	Walker B; other site
349521012560	D-loop; other site
349521012561	H-loop/switch region; other site
349521012562	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
349521012563	active site
349521012564	catalytic triad [active]
349521012565	oxyanion hole [active]
349521012566	switch loop; other site
349521012567	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521012568	dimerization interface [polypeptide binding]; other site
349521012569	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521012570	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521012571	dimer interface [polypeptide binding]; other site
349521012572	putative CheW interface [polypeptide binding]; other site
349521012573	universal stress protein UspE; Provisional; Region: PRK11175
349521012574	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349521012575	Ligand Binding Site [chemical binding]; other site
349521012576	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349521012577	Ligand Binding Site [chemical binding]; other site
349521012578	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
349521012579	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
349521012580	active site
349521012581	metal binding site [ion binding]; metal-binding site
349521012582	FGAM-synthase; Provisional; Region: PHA03366
349521012583	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
349521012584	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
349521012585	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
349521012586	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349521012587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521012588	S-adenosylmethionine binding site [chemical binding]; other site
349521012589	Ribosome modulation factor; Region: RMF; pfam04957
349521012590	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
349521012591	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
349521012592	quinone interaction residues [chemical binding]; other site
349521012593	active site
349521012594	catalytic residues [active]
349521012595	FMN binding site [chemical binding]; other site
349521012596	substrate binding site [chemical binding]; other site
349521012597	PilZ domain; Region: PilZ; pfam07238
349521012598	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
349521012599	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
349521012600	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
349521012601	Short C-terminal domain; Region: SHOCT; pfam09851
349521012602	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349521012603	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
349521012604	RmuC family; Region: RmuC; pfam02646
349521012605	excinuclease ABC subunit B; Provisional; Region: PRK05298
349521012606	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521012607	ATP binding site [chemical binding]; other site
349521012608	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521012609	nucleotide binding region [chemical binding]; other site
349521012610	ATP-binding site [chemical binding]; other site
349521012611	Ultra-violet resistance protein B; Region: UvrB; pfam12344
349521012612	UvrB/uvrC motif; Region: UVR; pfam02151
349521012613	aspartate aminotransferase; Provisional; Region: PRK05764
349521012614	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521012615	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521012616	homodimer interface [polypeptide binding]; other site
349521012617	catalytic residue [active]
349521012618	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
349521012619	active site
349521012620	dimer interface [polypeptide binding]; other site
349521012621	tetratricopeptide repeat protein; Provisional; Region: PRK11788
349521012622	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521012623	binding surface
349521012624	TPR motif; other site
349521012625	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
349521012626	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349521012627	IHF - DNA interface [nucleotide binding]; other site
349521012628	IHF dimer interface [polypeptide binding]; other site
349521012629	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
349521012630	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
349521012631	RNA binding site [nucleotide binding]; other site
349521012632	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
349521012633	RNA binding site [nucleotide binding]; other site
349521012634	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
349521012635	RNA binding site [nucleotide binding]; other site
349521012636	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
349521012637	RNA binding site [nucleotide binding]; other site
349521012638	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
349521012639	RNA binding site [nucleotide binding]; other site
349521012640	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
349521012641	RNA binding site [nucleotide binding]; other site
349521012642	cytidylate kinase; Provisional; Region: cmk; PRK00023
349521012643	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
349521012644	CMP-binding site; other site
349521012645	The sites determining sugar specificity; other site
349521012646	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
349521012647	prephenate dehydrogenase; Validated; Region: PRK08507
349521012648	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
349521012649	hinge; other site
349521012650	active site
349521012651	Chorismate mutase type II; Region: CM_2; cl00693
349521012652	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
349521012653	Prephenate dehydratase; Region: PDT; pfam00800
349521012654	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
349521012655	putative L-Phe binding site [chemical binding]; other site
349521012656	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
349521012657	homodimer interface [polypeptide binding]; other site
349521012658	substrate-cofactor binding pocket; other site
349521012659	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521012660	catalytic residue [active]
349521012661	DNA gyrase subunit A; Validated; Region: PRK05560
349521012662	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
349521012663	CAP-like domain; other site
349521012664	active site
349521012665	primary dimer interface [polypeptide binding]; other site
349521012666	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349521012667	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349521012668	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349521012669	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349521012670	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349521012671	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349521012672	FOG: CBS domain [General function prediction only]; Region: COG0517
349521012673	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
349521012674	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
349521012675	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
349521012676	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
349521012677	putative active site [active]
349521012678	putative substrate binding site [chemical binding]; other site
349521012679	putative cosubstrate binding site; other site
349521012680	catalytic site [active]
349521012681	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
349521012682	aromatic arch; other site
349521012683	DCoH dimer interaction site [polypeptide binding]; other site
349521012684	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
349521012685	DCoH tetramer interaction site [polypeptide binding]; other site
349521012686	substrate binding site [chemical binding]; other site
349521012687	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
349521012688	Fumarase C-terminus; Region: Fumerase_C; pfam05683
349521012689	Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262
349521012690	argininosuccinate synthase; Provisional; Region: PRK13820
349521012691	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
349521012692	ANP binding site [chemical binding]; other site
349521012693	Substrate Binding Site II [chemical binding]; other site
349521012694	Substrate Binding Site I [chemical binding]; other site
349521012695	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521012696	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521012697	ligand binding site [chemical binding]; other site
349521012698	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
349521012699	active site
349521012700	substrate binding pocket [chemical binding]; other site
349521012701	dimer interface [polypeptide binding]; other site
349521012702	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
349521012703	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
349521012704	dimer interface [polypeptide binding]; other site
349521012705	catalytic site [active]
349521012706	putative active site [active]
349521012707	putative substrate binding site [chemical binding]; other site
349521012708	peroxidase; Provisional; Region: PRK15000
349521012709	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
349521012710	dimer interface [polypeptide binding]; other site
349521012711	decamer (pentamer of dimers) interface [polypeptide binding]; other site
349521012712	catalytic triad [active]
349521012713	peroxidatic and resolving cysteines [active]
349521012714	short chain dehydrogenase; Provisional; Region: PRK07201
349521012715	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
349521012716	putative NAD(P) binding site [chemical binding]; other site
349521012717	active site
349521012718	putative substrate binding site [chemical binding]; other site
349521012719	classical (c) SDRs; Region: SDR_c; cd05233
349521012720	NAD(P) binding site [chemical binding]; other site
349521012721	active site
349521012722	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
349521012723	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521012724	NAD(P) binding site [chemical binding]; other site
349521012725	active site
349521012726	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
349521012727	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
349521012728	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
349521012729	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
349521012730	exonuclease I; Provisional; Region: sbcB; PRK11779
349521012731	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
349521012732	active site
349521012733	catalytic site [active]
349521012734	substrate binding site [chemical binding]; other site
349521012735	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
349521012736	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
349521012737	BolA-like protein; Region: BolA; cl00386
349521012738	BNR repeat-like domain; Region: BNR_2; pfam13088
349521012739	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
349521012740	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
349521012741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012742	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
349521012743	active site
349521012744	phosphorylation site [posttranslational modification]
349521012745	intermolecular recognition site; other site
349521012746	dimerization interface [polypeptide binding]; other site
349521012747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521012748	DNA binding site [nucleotide binding]
349521012749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
349521012750	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349521012751	FecR protein; Region: FecR; pfam04773
349521012752	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
349521012753	CHASE2 domain; Region: CHASE2; pfam05226
349521012754	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349521012755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
349521012756	dimer interface [polypeptide binding]; other site
349521012757	phosphorylation site [posttranslational modification]
349521012758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521012759	ATP binding site [chemical binding]; other site
349521012760	Mg2+ binding site [ion binding]; other site
349521012761	G-X-G motif; other site
349521012762	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862
349521012763	putative active site [active]
349521012764	Zn binding site [ion binding]; other site
349521012765	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521012766	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521012767	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521012768	ligand binding site [chemical binding]; other site
349521012769	MASE1; Region: MASE1; cl17823
349521012770	PAS domain; Region: PAS; smart00091
349521012771	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521012772	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521012773	metal binding site [ion binding]; metal-binding site
349521012774	active site
349521012775	I-site; other site
349521012776	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521012777	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
349521012778	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
349521012779	Walker A motif; other site
349521012780	ATP binding site [chemical binding]; other site
349521012781	Walker B motif; other site
349521012782	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
349521012783	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
349521012784	Domain of unknown function (DUF4291); Region: DUF4291; pfam14124
349521012785	Protein of unknown function (DUF938); Region: DUF938; pfam06080
349521012786	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
349521012787	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521012788	ATP binding site [chemical binding]; other site
349521012789	putative Mg++ binding site [ion binding]; other site
349521012790	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521012791	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
349521012792	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
349521012793	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
349521012794	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
349521012795	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
349521012796	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521012797	ATP binding site [chemical binding]; other site
349521012798	putative Mg++ binding site [ion binding]; other site
349521012799	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
349521012800	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
349521012801	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
349521012802	HsdM N-terminal domain; Region: HsdM_N; pfam12161
349521012803	Methyltransferase domain; Region: Methyltransf_26; pfam13659
349521012804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521012805	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
349521012806	Walker A motif; other site
349521012807	ATP binding site [chemical binding]; other site
349521012808	Walker B motif; other site
349521012809	arginine finger; other site
349521012810	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521012811	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
349521012812	Integrase core domain; Region: rve_3; cl15866
349521012813	Predicted flavoprotein [General function prediction only]; Region: COG0431
349521012814	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349521012815	C factor cell-cell signaling protein; Provisional; Region: PRK09009
349521012816	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
349521012817	NADP binding site [chemical binding]; other site
349521012818	homodimer interface [polypeptide binding]; other site
349521012819	active site
349521012820	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
349521012821	Ligand binding site; other site
349521012822	metal-binding site
349521012823	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
349521012824	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349521012825	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
349521012826	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
349521012827	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
349521012828	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349521012829	catalytic loop [active]
349521012830	iron binding site [ion binding]; other site
349521012831	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
349521012832	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
349521012833	putative catalytic site [active]
349521012834	metal binding site A [ion binding]; metal-binding site
349521012835	phosphate binding site [ion binding]; other site
349521012836	metal binding site C [ion binding]; metal-binding site
349521012837	metal binding site B [ion binding]; metal-binding site
349521012838	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
349521012839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
349521012840	Smr domain; Region: Smr; pfam01713
349521012841	TM2 domain; Region: TM2; pfam05154
349521012842	TM2 domain; Region: TM2; pfam05154
349521012843	Protein of unknown function DUF45; Region: DUF45; pfam01863
349521012844	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521012845	dimerization interface [polypeptide binding]; other site
349521012846	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521012847	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521012848	dimer interface [polypeptide binding]; other site
349521012849	putative CheW interface [polypeptide binding]; other site
349521012850	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
349521012851	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521012852	acyl-activating enzyme (AAE) consensus motif; other site
349521012853	AMP binding site [chemical binding]; other site
349521012854	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
349521012855	FAD binding pocket [chemical binding]; other site
349521012856	phosphate binding motif [ion binding]; other site
349521012857	beta-alpha-beta structure motif; other site
349521012858	NAD binding pocket [chemical binding]; other site
349521012859	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521012860	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
349521012861	substrate binding site [chemical binding]; other site
349521012862	oxyanion hole (OAH) forming residues; other site
349521012863	trimer interface [polypeptide binding]; other site
349521012864	PilZ domain; Region: PilZ; pfam07238
349521012865	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
349521012866	active site
349521012867	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
349521012868	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521012869	ligand binding site [chemical binding]; other site
349521012870	flexible hinge region; other site
349521012871	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
349521012872	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349521012873	metal binding triad; other site
349521012874	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
349521012875	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
349521012876	active site
349521012877	catalytic site [active]
349521012878	substrate binding site [chemical binding]; other site
349521012879	ATP-dependent helicase HepA; Validated; Region: PRK04914
349521012880	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521012881	ATP binding site [chemical binding]; other site
349521012882	putative Mg++ binding site [ion binding]; other site
349521012883	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521012884	nucleotide binding region [chemical binding]; other site
349521012885	ATP-binding site [chemical binding]; other site
349521012886	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
349521012887	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
349521012888	active site
349521012889	NAD binding site [chemical binding]; other site
349521012890	metal binding site [ion binding]; metal-binding site
349521012891	SCP-2 sterol transfer family; Region: SCP2; cl01225
349521012892	KWG Leptospira; Region: KWG; pfam07656
349521012893	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
349521012894	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
349521012895	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
349521012896	hypothetical protein; Reviewed; Region: PRK09588
349521012897	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
349521012898	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
349521012899	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
349521012900	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
349521012901	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
349521012902	Na binding site [ion binding]; other site
349521012903	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
349521012904	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
349521012905	Na binding site [ion binding]; other site
349521012906	PAS fold; Region: PAS_7; pfam12860
349521012907	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521012908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521012909	dimer interface [polypeptide binding]; other site
349521012910	phosphorylation site [posttranslational modification]
349521012911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521012912	ATP binding site [chemical binding]; other site
349521012913	Mg2+ binding site [ion binding]; other site
349521012914	G-X-G motif; other site
349521012915	Response regulator receiver domain; Region: Response_reg; pfam00072
349521012916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012917	active site
349521012918	phosphorylation site [posttranslational modification]
349521012919	intermolecular recognition site; other site
349521012920	dimerization interface [polypeptide binding]; other site
349521012921	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349521012922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012923	active site
349521012924	phosphorylation site [posttranslational modification]
349521012925	intermolecular recognition site; other site
349521012926	dimerization interface [polypeptide binding]; other site
349521012927	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521012928	DNA binding residues [nucleotide binding]
349521012929	dimerization interface [polypeptide binding]; other site
349521012930	acetyl-CoA synthetase; Provisional; Region: PRK00174
349521012931	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
349521012932	active site
349521012933	CoA binding site [chemical binding]; other site
349521012934	acyl-activating enzyme (AAE) consensus motif; other site
349521012935	AMP binding site [chemical binding]; other site
349521012936	acetate binding site [chemical binding]; other site
349521012937	fatty acyl-CoA reductase; Region: PLN02996
349521012938	fatty acyl CoA reductases (FARs), extended (e) SDRs; Region: FAR-N_SDR_e; cd05236
349521012939	putative NAD(P) binding site [chemical binding]; other site
349521012940	active site
349521012941	putative substrate binding site [chemical binding]; other site
349521012942	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071
349521012943	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349521012944	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521012945	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349521012946	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521012947	S-adenosylmethionine binding site [chemical binding]; other site
349521012948	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
349521012949	glutamate racemase; Provisional; Region: PRK00865
349521012950	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
349521012951	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
349521012952	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
349521012953	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
349521012954	putative NADH binding site [chemical binding]; other site
349521012955	putative active site [active]
349521012956	nudix motif; other site
349521012957	putative metal binding site [ion binding]; other site
349521012958	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
349521012959	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
349521012960	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
349521012961	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
349521012962	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349521012963	Walker A/P-loop; other site
349521012964	ATP binding site [chemical binding]; other site
349521012965	Q-loop/lid; other site
349521012966	ABC transporter signature motif; other site
349521012967	Walker B; other site
349521012968	D-loop; other site
349521012969	H-loop/switch region; other site
349521012970	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
349521012971	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
349521012972	putative acyl-acceptor binding pocket; other site
349521012973	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349521012974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012975	active site
349521012976	phosphorylation site [posttranslational modification]
349521012977	intermolecular recognition site; other site
349521012978	dimerization interface [polypeptide binding]; other site
349521012979	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521012980	DNA binding residues [nucleotide binding]
349521012981	dimerization interface [polypeptide binding]; other site
349521012982	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521012983	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521012984	dimer interface [polypeptide binding]; other site
349521012985	phosphorylation site [posttranslational modification]
349521012986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521012987	ATP binding site [chemical binding]; other site
349521012988	Mg2+ binding site [ion binding]; other site
349521012989	G-X-G motif; other site
349521012990	Response regulator receiver domain; Region: Response_reg; pfam00072
349521012991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521012992	active site
349521012993	phosphorylation site [posttranslational modification]
349521012994	intermolecular recognition site; other site
349521012995	dimerization interface [polypeptide binding]; other site
349521012996	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
349521012997	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
349521012998	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
349521012999	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349521013000	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
349521013001	Uncharacterized conserved protein [Function unknown]; Region: COG3791
349521013002	Secretion system effector C (SseC) like family; Region: SseC; pfam04888
349521013003	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
349521013004	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521013005	binding surface
349521013006	TPR motif; other site
349521013007	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
349521013008	FHIPEP family; Region: FHIPEP; pfam00771
349521013009	Type III secretion system YscX (type_III_YscX); Region: Type_III_YscX; cl09710
349521013010	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349521013011	anti sigma factor interaction site; other site
349521013012	regulatory phosphorylation site [posttranslational modification]; other site
349521013013	type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503
349521013014	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
349521013015	TyeA; Region: TyeA; cl07611
349521013016	type III secretion system ATPase; Provisional; Region: PRK06936
349521013017	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349521013018	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
349521013019	Walker A motif/ATP binding site; other site
349521013020	Walker B motif; other site
349521013021	Type III secretion protein YscO; Region: YscO; pfam07321
349521013022	type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514
349521013023	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
349521013024	type III secretion system protein YscR; Provisional; Region: PRK12797
349521013025	type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403
349521013026	Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791
349521013027	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
349521013028	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
349521013029	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521013030	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
349521013031	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
349521013032	putative active site [active]
349521013033	Zn binding site [ion binding]; other site
349521013034	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521013035	Coenzyme A binding pocket [chemical binding]; other site
349521013036	type III secretion system protein; Reviewed; Region: PRK06937
349521013037	Flagellar assembly protein FliH; Region: FliH; pfam02108
349521013038	YOP proteins translocation protein K (YscK); Region: YscK; pfam06578
349521013039	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
349521013040	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
349521013041	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
349521013042	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349521013043	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349521013044	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349521013045	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
349521013046	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
349521013047	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349521013048	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521013049	DNA binding residues [nucleotide binding]
349521013050	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521013051	non-specific DNA binding site [nucleotide binding]; other site
349521013052	salt bridge; other site
349521013053	sequence-specific DNA binding site [nucleotide binding]; other site
349521013054	AAA ATPase domain; Region: AAA_16; pfam13191
349521013055	Type III secretion system regulator (LcrR); Region: LcrR; cl09838
349521013056	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
349521013057	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521013058	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
349521013059	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521013060	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521013061	NAD(P) binding site [chemical binding]; other site
349521013062	active site
349521013063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521013064	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521013065	putative substrate translocation pore; other site
349521013066	transcriptional regulator SlyA; Provisional; Region: PRK03573
349521013067	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
349521013068	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521013069	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521013070	putative DNA binding site [nucleotide binding]; other site
349521013071	putative Zn2+ binding site [ion binding]; other site
349521013072	AsnC family; Region: AsnC_trans_reg; pfam01037
349521013073	2-isopropylmalate synthase; Validated; Region: PRK03739
349521013074	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
349521013075	active site
349521013076	catalytic residues [active]
349521013077	metal binding site [ion binding]; metal-binding site
349521013078	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
349521013079	cytosine deaminase; Provisional; Region: PRK09230
349521013080	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
349521013081	active site
349521013082	YebG protein; Region: YebG; pfam07130
349521013083	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521013084	ATP binding site [chemical binding]; other site
349521013085	Mg2+ binding site [ion binding]; other site
349521013086	G-X-G motif; other site
349521013087	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
349521013088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521013089	active site
349521013090	phosphorylation site [posttranslational modification]
349521013091	intermolecular recognition site; other site
349521013092	dimerization interface [polypeptide binding]; other site
349521013093	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521013094	DNA binding residues [nucleotide binding]
349521013095	dimerization interface [polypeptide binding]; other site
349521013096	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
349521013097	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
349521013098	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349521013099	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
349521013100	Soluble P-type ATPase [General function prediction only]; Region: COG4087
349521013101	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
349521013102	Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468
349521013103	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
349521013104	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
349521013105	putative CheA interaction surface; other site
349521013106	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
349521013107	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349521013108	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349521013109	P-loop; other site
349521013110	Magnesium ion binding site [ion binding]; other site
349521013111	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349521013112	Magnesium ion binding site [ion binding]; other site
349521013113	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
349521013114	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
349521013115	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521013116	ligand binding site [chemical binding]; other site
349521013117	flagellar motor protein; Reviewed; Region: motC; PRK09109
349521013118	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
349521013119	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
349521013120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521013121	active site
349521013122	phosphorylation site [posttranslational modification]
349521013123	intermolecular recognition site; other site
349521013124	dimerization interface [polypeptide binding]; other site
349521013125	CheB methylesterase; Region: CheB_methylest; pfam01339
349521013126	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521013127	putative binding surface; other site
349521013128	active site
349521013129	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
349521013130	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
349521013131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521013132	ATP binding site [chemical binding]; other site
349521013133	Mg2+ binding site [ion binding]; other site
349521013134	G-X-G motif; other site
349521013135	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
349521013136	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
349521013137	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
349521013138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521013139	active site
349521013140	phosphorylation site [posttranslational modification]
349521013141	intermolecular recognition site; other site
349521013142	dimerization interface [polypeptide binding]; other site
349521013143	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
349521013144	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349521013145	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
349521013146	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521013147	DNA binding residues [nucleotide binding]
349521013148	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
349521013149	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349521013150	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
349521013151	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
349521013152	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349521013153	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
349521013154	FHIPEP family; Region: FHIPEP; pfam00771
349521013155	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
349521013156	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
349521013157	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
349521013158	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
349521013159	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
349521013160	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
349521013161	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
349521013162	flagellar motor switch protein; Validated; Region: fliN; PRK05698
349521013163	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
349521013164	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
349521013165	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
349521013166	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
349521013167	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521013168	putative binding surface; other site
349521013169	active site
349521013170	Response regulator receiver domain; Region: Response_reg; pfam00072
349521013171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521013172	active site
349521013173	phosphorylation site [posttranslational modification]
349521013174	intermolecular recognition site; other site
349521013175	dimerization interface [polypeptide binding]; other site
349521013176	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
349521013177	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
349521013178	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349521013179	anti sigma factor interaction site; other site
349521013180	regulatory phosphorylation site [posttranslational modification]; other site
349521013181	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
349521013182	Flagellar FliJ protein; Region: FliJ; pfam02050
349521013183	flagellum-specific ATP synthase; Validated; Region: fliI; PRK05688
349521013184	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349521013185	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
349521013186	Walker A motif/ATP binding site; other site
349521013187	Walker B motif; other site
349521013188	flagellar assembly protein H; Validated; Region: fliH; PRK05687
349521013189	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
349521013190	Flagellar assembly protein FliH; Region: FliH; pfam02108
349521013191	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
349521013192	MgtE intracellular N domain; Region: MgtE_N; smart00924
349521013193	FliG C-terminal domain; Region: FliG_C; pfam01706
349521013194	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
349521013195	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
349521013196	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
349521013197	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
349521013198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521013199	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349521013200	active site
349521013201	phosphorylation site [posttranslational modification]
349521013202	intermolecular recognition site; other site
349521013203	dimerization interface [polypeptide binding]; other site
349521013204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521013205	Walker A motif; other site
349521013206	ATP binding site [chemical binding]; other site
349521013207	Walker B motif; other site
349521013208	arginine finger; other site
349521013209	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521013210	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349521013211	PAS domain; Region: PAS_8; pfam13188
349521013212	putative active site [active]
349521013213	heme pocket [chemical binding]; other site
349521013214	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521013215	dimer interface [polypeptide binding]; other site
349521013216	phosphorylation site [posttranslational modification]
349521013217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521013218	ATP binding site [chemical binding]; other site
349521013219	Mg2+ binding site [ion binding]; other site
349521013220	G-X-G motif; other site
349521013221	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
349521013222	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349521013223	putative active site [active]
349521013224	putative NTP binding site [chemical binding]; other site
349521013225	putative nucleic acid binding site [nucleotide binding]; other site
349521013226	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
349521013227	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349521013228	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
349521013229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521013230	Walker A motif; other site
349521013231	ATP binding site [chemical binding]; other site
349521013232	Walker B motif; other site
349521013233	arginine finger; other site
349521013234	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521013235	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
349521013236	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
349521013237	oxaloacetate decarboxylase; Provisional; Region: PRK14040
349521013238	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
349521013239	active site
349521013240	catalytic residues [active]
349521013241	metal binding site [ion binding]; metal-binding site
349521013242	homodimer binding site [polypeptide binding]; other site
349521013243	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349521013244	carboxyltransferase (CT) interaction site; other site
349521013245	biotinylation site [posttranslational modification]; other site
349521013246	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
349521013247	carbon storage regulator; Provisional; Region: PRK01712
349521013248	aspartate kinase; Reviewed; Region: PRK06635
349521013249	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
349521013250	putative nucleotide binding site [chemical binding]; other site
349521013251	putative catalytic residues [active]
349521013252	putative Mg ion binding site [ion binding]; other site
349521013253	putative aspartate binding site [chemical binding]; other site
349521013254	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
349521013255	putative allosteric regulatory site; other site
349521013256	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
349521013257	putative allosteric regulatory residue; other site
349521013258	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
349521013259	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
349521013260	motif 1; other site
349521013261	active site
349521013262	motif 2; other site
349521013263	motif 3; other site
349521013264	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
349521013265	DHHA1 domain; Region: DHHA1; pfam02272
349521013266	UbiA prenyltransferase family; Region: UbiA; pfam01040
349521013267	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
349521013268	RDD family; Region: RDD; pfam06271
349521013269	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
349521013270	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
349521013271	Walker A/P-loop; other site
349521013272	ATP binding site [chemical binding]; other site
349521013273	Q-loop/lid; other site
349521013274	ABC transporter signature motif; other site
349521013275	Walker B; other site
349521013276	D-loop; other site
349521013277	H-loop/switch region; other site
349521013278	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
349521013279	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521013280	substrate binding pocket [chemical binding]; other site
349521013281	membrane-bound complex binding site; other site
349521013282	hinge residues; other site
349521013283	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
349521013284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521013285	dimer interface [polypeptide binding]; other site
349521013286	conserved gate region; other site
349521013287	putative PBP binding loops; other site
349521013288	ABC-ATPase subunit interface; other site
349521013289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521013290	dimer interface [polypeptide binding]; other site
349521013291	conserved gate region; other site
349521013292	putative PBP binding loops; other site
349521013293	ABC-ATPase subunit interface; other site
349521013294	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
349521013295	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
349521013296	putative active site [active]
349521013297	Zn binding site [ion binding]; other site
349521013298	Response regulator receiver domain; Region: Response_reg; pfam00072
349521013299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521013300	active site
349521013301	phosphorylation site [posttranslational modification]
349521013302	intermolecular recognition site; other site
349521013303	dimerization interface [polypeptide binding]; other site
349521013304	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
349521013305	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521013306	putative active site [active]
349521013307	heme pocket [chemical binding]; other site
349521013308	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521013309	dimer interface [polypeptide binding]; other site
349521013310	phosphorylation site [posttranslational modification]
349521013311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521013312	ATP binding site [chemical binding]; other site
349521013313	Mg2+ binding site [ion binding]; other site
349521013314	G-X-G motif; other site
349521013315	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
349521013316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521013317	active site
349521013318	phosphorylation site [posttranslational modification]
349521013319	intermolecular recognition site; other site
349521013320	dimerization interface [polypeptide binding]; other site
349521013321	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521013322	DNA binding residues [nucleotide binding]
349521013323	dimerization interface [polypeptide binding]; other site
349521013324	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
349521013325	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521013326	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
349521013327	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521013328	FeS/SAM binding site; other site
349521013329	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
349521013330	Ion transport protein; Region: Ion_trans; pfam00520
349521013331	Ion channel; Region: Ion_trans_2; pfam07885
349521013332	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
349521013333	AAA domain; Region: AAA_32; pfam13654
349521013334	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
349521013335	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
349521013336	PilZ domain; Region: PilZ; pfam07238
349521013337	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
349521013338	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
349521013339	GTP binding site; other site
349521013340	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
349521013341	MoaE homodimer interface [polypeptide binding]; other site
349521013342	MoaD interaction [polypeptide binding]; other site
349521013343	active site residues [active]
349521013344	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
349521013345	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349521013346	Interdomain contacts; other site
349521013347	Cytokine receptor motif; other site
349521013348	recombinase A; Provisional; Region: recA; PRK09354
349521013349	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
349521013350	hexamer interface [polypeptide binding]; other site
349521013351	Walker A motif; other site
349521013352	ATP binding site [chemical binding]; other site
349521013353	Walker B motif; other site
349521013354	Competence-damaged protein; Region: CinA; cl00666
349521013355	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
349521013356	MutS domain I; Region: MutS_I; pfam01624
349521013357	MutS domain II; Region: MutS_II; pfam05188
349521013358	MutS domain III; Region: MutS_III; pfam05192
349521013359	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
349521013360	Walker A/P-loop; other site
349521013361	ATP binding site [chemical binding]; other site
349521013362	Q-loop/lid; other site
349521013363	ABC transporter signature motif; other site
349521013364	Walker B; other site
349521013365	D-loop; other site
349521013366	H-loop/switch region; other site
349521013367	Ferredoxin [Energy production and conversion]; Region: COG1146
349521013368	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
349521013369	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521013370	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
349521013371	RNA/DNA hybrid binding site [nucleotide binding]; other site
349521013372	active site
349521013373	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
349521013374	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
349521013375	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
349521013376	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
349521013377	active site
349521013378	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
349521013379	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
349521013380	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
349521013381	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
349521013382	trimer interface [polypeptide binding]; other site
349521013383	active site
349521013384	UDP-GlcNAc binding site [chemical binding]; other site
349521013385	lipid binding site [chemical binding]; lipid-binding site
349521013386	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
349521013387	periplasmic chaperone; Provisional; Region: PRK10780
349521013388	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
349521013389	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349521013390	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349521013391	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349521013392	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349521013393	Surface antigen; Region: Bac_surface_Ag; pfam01103
349521013394	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
349521013395	zinc metallopeptidase RseP; Provisional; Region: PRK10779
349521013396	active site
349521013397	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
349521013398	protein binding site [polypeptide binding]; other site
349521013399	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
349521013400	protein binding site [polypeptide binding]; other site
349521013401	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
349521013402	putative substrate binding region [chemical binding]; other site
349521013403	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
349521013404	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
349521013405	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
349521013406	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
349521013407	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
349521013408	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
349521013409	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
349521013410	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
349521013411	catalytic residue [active]
349521013412	putative FPP diphosphate  binding site; other site
349521013413	putative FPP binding hydrophobic cleft; other site
349521013414	dimer interface [polypeptide binding]; other site
349521013415	putative IPP diphosphate binding site; other site
349521013416	ribosome recycling factor; Reviewed; Region: frr; PRK00083
349521013417	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
349521013418	hinge region; other site
349521013419	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
349521013420	putative nucleotide binding site [chemical binding]; other site
349521013421	uridine monophosphate binding site [chemical binding]; other site
349521013422	homohexameric interface [polypeptide binding]; other site
349521013423	elongation factor Ts; Provisional; Region: tsf; PRK09377
349521013424	UBA/TS-N domain; Region: UBA; pfam00627
349521013425	Elongation factor TS; Region: EF_TS; pfam00889
349521013426	Elongation factor TS; Region: EF_TS; pfam00889
349521013427	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
349521013428	rRNA interaction site [nucleotide binding]; other site
349521013429	S8 interaction site; other site
349521013430	putative laminin-1 binding site; other site
349521013431	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
349521013432	active site
349521013433	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
349521013434	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349521013435	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
349521013436	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521013437	Zn2+ binding site [ion binding]; other site
349521013438	Mg2+ binding site [ion binding]; other site
349521013439	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
349521013440	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
349521013441	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
349521013442	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521013443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521013444	homodimer interface [polypeptide binding]; other site
349521013445	catalytic residue [active]
349521013446	ArsC family; Region: ArsC; pfam03960
349521013447	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
349521013448	putative catalytic residues [active]
349521013449	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
349521013450	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
349521013451	putative trimer interface [polypeptide binding]; other site
349521013452	putative CoA binding site [chemical binding]; other site
349521013453	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
349521013454	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
349521013455	metal binding site [ion binding]; metal-binding site
349521013456	dimer interface [polypeptide binding]; other site
349521013457	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
349521013458	DNA-binding site [nucleotide binding]; DNA binding site
349521013459	RNA-binding motif; other site
349521013460	SlyX; Region: SlyX; pfam04102
349521013461	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
349521013462	ligand binding site; other site
349521013463	tetramer interface; other site
349521013464	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
349521013465	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
349521013466	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
349521013467	NeuB family; Region: NeuB; pfam03102
349521013468	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
349521013469	NeuB binding interface [polypeptide binding]; other site
349521013470	putative substrate binding site [chemical binding]; other site
349521013471	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
349521013472	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
349521013473	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
349521013474	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
349521013475	putative glycosyl transferase; Provisional; Region: PRK10018
349521013476	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
349521013477	active site
349521013478	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
349521013479	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
349521013480	DXD motif; other site
349521013481	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521013482	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
349521013483	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349521013484	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
349521013485	Ligand binding site; other site
349521013486	Putative Catalytic site; other site
349521013487	DXD motif; other site
349521013488	Pilin (bacterial filament); Region: Pilin; pfam00114
349521013489	Pilin (bacterial filament); Region: Pilin; pfam00114
349521013490	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
349521013491	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
349521013492	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
349521013493	Walker A motif; other site
349521013494	ATP binding site [chemical binding]; other site
349521013495	Walker B motif; other site
349521013496	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
349521013497	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349521013498	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349521013499	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
349521013500	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
349521013501	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
349521013502	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
349521013503	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
349521013504	CoA-binding site [chemical binding]; other site
349521013505	ATP-binding [chemical binding]; other site
349521013506	Domain of unknown function (DUF329); Region: DUF329; pfam03884
349521013507	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
349521013508	homodimer interaction site [polypeptide binding]; other site
349521013509	cofactor binding site; other site
349521013510	PilZ domain; Region: PilZ; pfam07238
349521013511	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
349521013512	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521013513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521013514	dimer interface [polypeptide binding]; other site
349521013515	phosphorylation site [posttranslational modification]
349521013516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521013517	ATP binding site [chemical binding]; other site
349521013518	Mg2+ binding site [ion binding]; other site
349521013519	G-X-G motif; other site
349521013520	Response regulator receiver domain; Region: Response_reg; pfam00072
349521013521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521013522	active site
349521013523	phosphorylation site [posttranslational modification]
349521013524	intermolecular recognition site; other site
349521013525	dimerization interface [polypeptide binding]; other site
349521013526	Response regulator receiver domain; Region: Response_reg; pfam00072
349521013527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521013528	active site
349521013529	phosphorylation site [posttranslational modification]
349521013530	intermolecular recognition site; other site
349521013531	dimerization interface [polypeptide binding]; other site
349521013532	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
349521013533	TrkA-N domain; Region: TrkA_N; pfam02254
349521013534	Protein of unknown function (DUF3187); Region: DUF3187; pfam11383
349521013535	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
349521013536	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
349521013537	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349521013538	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
349521013539	putative acyl-acceptor binding pocket; other site
349521013540	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
349521013541	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
349521013542	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
349521013543	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349521013544	dimer interface [polypeptide binding]; other site
349521013545	active site
349521013546	Predicted ATPase [General function prediction only]; Region: COG1485
349521013547	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
349521013548	Uncharacterized conserved protein [Function unknown]; Region: COG0327
349521013549	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
349521013550	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
349521013551	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349521013552	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349521013553	protein binding site [polypeptide binding]; other site
349521013554	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
349521013555	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521013556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521013557	homodimer interface [polypeptide binding]; other site
349521013558	catalytic residue [active]
349521013559	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
349521013560	histidinol dehydrogenase; Region: hisD; TIGR00069
349521013561	NAD binding site [chemical binding]; other site
349521013562	dimerization interface [polypeptide binding]; other site
349521013563	product binding site; other site
349521013564	substrate binding site [chemical binding]; other site
349521013565	zinc binding site [ion binding]; other site
349521013566	catalytic residues [active]
349521013567	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
349521013568	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
349521013569	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
349521013570	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
349521013571	hinge; other site
349521013572	active site
349521013573	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
349521013574	STAS domain; Region: STAS_2; pfam13466
349521013575	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
349521013576	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
349521013577	mce related protein; Region: MCE; pfam02470
349521013578	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
349521013579	Permease; Region: Permease; cl00510
349521013580	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
349521013581	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
349521013582	Walker A/P-loop; other site
349521013583	ATP binding site [chemical binding]; other site
349521013584	Q-loop/lid; other site
349521013585	ABC transporter signature motif; other site
349521013586	Walker B; other site
349521013587	D-loop; other site
349521013588	H-loop/switch region; other site
349521013589	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
349521013590	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
349521013591	putative active site [active]
349521013592	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
349521013593	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
349521013594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521013595	active site
349521013596	motif I; other site
349521013597	motif II; other site
349521013598	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
349521013599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
349521013600	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
349521013601	OstA-like protein; Region: OstA; pfam03968
349521013602	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
349521013603	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
349521013604	Walker A/P-loop; other site
349521013605	ATP binding site [chemical binding]; other site
349521013606	Q-loop/lid; other site
349521013607	ABC transporter signature motif; other site
349521013608	Walker B; other site
349521013609	D-loop; other site
349521013610	H-loop/switch region; other site
349521013611	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
349521013612	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
349521013613	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
349521013614	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
349521013615	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
349521013616	30S subunit binding site; other site
349521013617	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
349521013618	active site
349521013619	phosphorylation site [posttranslational modification]
349521013620	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
349521013621	AAA domain; Region: AAA_33; pfam13671
349521013622	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
349521013623	dimerization domain swap beta strand [polypeptide binding]; other site
349521013624	regulatory protein interface [polypeptide binding]; other site
349521013625	active site
349521013626	regulatory phosphorylation site [posttranslational modification]; other site
349521013627	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
349521013628	MgtE intracellular N domain; Region: MgtE_N; smart00924
349521013629	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
349521013630	Divalent cation transporter; Region: MgtE; pfam01769
349521013631	Protein of unknown function (DUF615); Region: DUF615; pfam04751
349521013632	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
349521013633	nitrilase; Region: PLN02798
349521013634	putative active site [active]
349521013635	catalytic triad [active]
349521013636	dimer interface [polypeptide binding]; other site
349521013637	TIGR02099 family protein; Region: TIGR02099
349521013638	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
349521013639	ribonuclease G; Provisional; Region: PRK11712
349521013640	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
349521013641	homodimer interface [polypeptide binding]; other site
349521013642	oligonucleotide binding site [chemical binding]; other site
349521013643	Maf-like protein; Region: Maf; pfam02545
349521013644	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
349521013645	active site
349521013646	dimer interface [polypeptide binding]; other site
349521013647	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
349521013648	rod shape-determining protein MreC; Provisional; Region: PRK13922
349521013649	rod shape-determining protein MreC; Region: MreC; pfam04085
349521013650	rod shape-determining protein MreB; Provisional; Region: PRK13927
349521013651	MreB and similar proteins; Region: MreB_like; cd10225
349521013652	nucleotide binding site [chemical binding]; other site
349521013653	Mg binding site [ion binding]; other site
349521013654	putative protofilament interaction site [polypeptide binding]; other site
349521013655	RodZ interaction site [polypeptide binding]; other site
349521013656	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
349521013657	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
349521013658	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
349521013659	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
349521013660	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
349521013661	GatB domain; Region: GatB_Yqey; smart00845
349521013662	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
349521013663	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
349521013664	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521013665	FeS/SAM binding site; other site
349521013666	PilZ domain; Region: PilZ; pfam07238
349521013667	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
349521013668	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
349521013669	Active Sites [active]
349521013670	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
349521013671	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
349521013672	CysD dimerization site [polypeptide binding]; other site
349521013673	G1 box; other site
349521013674	putative GEF interaction site [polypeptide binding]; other site
349521013675	GTP/Mg2+ binding site [chemical binding]; other site
349521013676	Switch I region; other site
349521013677	G2 box; other site
349521013678	G3 box; other site
349521013679	Switch II region; other site
349521013680	G4 box; other site
349521013681	G5 box; other site
349521013682	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
349521013683	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
349521013684	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
349521013685	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
349521013686	homodimer interface [polypeptide binding]; other site
349521013687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521013688	catalytic residue [active]
349521013689	Nucleoid-associated protein [General function prediction only]; Region: COG3081
349521013690	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
349521013691	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
349521013692	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
349521013693	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
349521013694	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521013695	FeS/SAM binding site; other site
349521013696	TRAM domain; Region: TRAM; pfam01938
349521013697	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
349521013698	PhoH-like protein; Region: PhoH; pfam02562
349521013699	metal-binding heat shock protein; Provisional; Region: PRK00016
349521013700	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
349521013701	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
349521013702	Transporter associated domain; Region: CorC_HlyC; smart01091
349521013703	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
349521013704	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521013705	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
349521013706	putative active site [active]
349521013707	catalytic triad [active]
349521013708	putative dimer interface [polypeptide binding]; other site
349521013709	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
349521013710	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
349521013711	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
349521013712	HIGH motif; other site
349521013713	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
349521013714	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349521013715	active site
349521013716	KMSKS motif; other site
349521013717	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
349521013718	tRNA binding surface [nucleotide binding]; other site
349521013719	Lipopolysaccharide-assembly; Region: LptE; cl01125
349521013720	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
349521013721	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
349521013722	Endonuclease I; Region: Endonuclease_1; pfam04231
349521013723	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
349521013724	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
349521013725	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521013726	active site
349521013727	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
349521013728	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
349521013729	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
349521013730	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521013731	active site
349521013732	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
349521013733	SprA-related family; Region: SprA-related; pfam12118
349521013734	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
349521013735	AAA domain; Region: AAA_26; pfam13500
349521013736	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
349521013737	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
349521013738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521013739	S-adenosylmethionine binding site [chemical binding]; other site
349521013740	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
349521013741	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
349521013742	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
349521013743	substrate-cofactor binding pocket; other site
349521013744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521013745	catalytic residue [active]
349521013746	biotin synthase; Provisional; Region: PRK15108
349521013747	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521013748	FeS/SAM binding site; other site
349521013749	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
349521013750	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
349521013751	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521013752	active site
349521013753	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
349521013754	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349521013755	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521013756	EamA-like transporter family; Region: EamA; pfam00892
349521013757	EamA-like transporter family; Region: EamA; pfam00892
349521013758	Uncharacterized conserved protein [Function unknown]; Region: COG3268
349521013759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521013760	NAD(P) binding site [chemical binding]; other site
349521013761	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
349521013762	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
349521013763	GDP-binding site [chemical binding]; other site
349521013764	ACT binding site; other site
349521013765	IMP binding site; other site
349521013766	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
349521013767	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
349521013768	dimer interface [polypeptide binding]; other site
349521013769	motif 1; other site
349521013770	active site
349521013771	motif 2; other site
349521013772	motif 3; other site
349521013773	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
349521013774	HflC protein; Region: hflC; TIGR01932
349521013775	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
349521013776	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
349521013777	HflK protein; Region: hflK; TIGR01933
349521013778	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
349521013779	GTPase HflX; Provisional; Region: PRK11058
349521013780	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
349521013781	HflX GTPase family; Region: HflX; cd01878
349521013782	G1 box; other site
349521013783	GTP/Mg2+ binding site [chemical binding]; other site
349521013784	Switch I region; other site
349521013785	G2 box; other site
349521013786	G3 box; other site
349521013787	Switch II region; other site
349521013788	G4 box; other site
349521013789	G5 box; other site
349521013790	bacterial Hfq-like; Region: Hfq; cd01716
349521013791	hexamer interface [polypeptide binding]; other site
349521013792	Sm1 motif; other site
349521013793	RNA binding site [nucleotide binding]; other site
349521013794	Sm2 motif; other site
349521013795	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
349521013796	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
349521013797	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
349521013798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521013799	ATP binding site [chemical binding]; other site
349521013800	Mg2+ binding site [ion binding]; other site
349521013801	G-X-G motif; other site
349521013802	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
349521013803	ATP binding site [chemical binding]; other site
349521013804	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
349521013805	AMIN domain; Region: AMIN; pfam11741
349521013806	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
349521013807	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
349521013808	active site
349521013809	metal binding site [ion binding]; metal-binding site
349521013810	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349521013811	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
349521013812	Uncharacterized conserved protein [Function unknown]; Region: COG0062
349521013813	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
349521013814	putative substrate binding site [chemical binding]; other site
349521013815	putative ATP binding site [chemical binding]; other site
349521013816	epoxyqueuosine reductase; Region: TIGR00276
349521013817	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
349521013818	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
349521013819	catalytic site [active]
349521013820	putative active site [active]
349521013821	putative substrate binding site [chemical binding]; other site
349521013822	dimer interface [polypeptide binding]; other site
349521013823	GTPase RsgA; Reviewed; Region: PRK12288
349521013824	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
349521013825	RNA binding site [nucleotide binding]; other site
349521013826	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
349521013827	GTPase/Zn-binding domain interface [polypeptide binding]; other site
349521013828	GTP/Mg2+ binding site [chemical binding]; other site
349521013829	G4 box; other site
349521013830	G5 box; other site
349521013831	G1 box; other site
349521013832	Switch I region; other site
349521013833	G2 box; other site
349521013834	G3 box; other site
349521013835	Switch II region; other site
349521013836	flagellar motor protein MotB; Validated; Region: motB; PRK09041
349521013837	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
349521013838	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521013839	ligand binding site [chemical binding]; other site
349521013840	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
349521013841	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
349521013842	HDOD domain; Region: HDOD; pfam08668
349521013843	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
349521013844	active site residue [active]
349521013845	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
349521013846	active site residue [active]
349521013847	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
349521013848	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349521013849	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
349521013850	motif 1; other site
349521013851	dimer interface [polypeptide binding]; other site
349521013852	active site
349521013853	motif 2; other site
349521013854	motif 3; other site
349521013855	elongation factor P; Validated; Region: PRK00529
349521013856	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
349521013857	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
349521013858	RNA binding site [nucleotide binding]; other site
349521013859	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
349521013860	RNA binding site [nucleotide binding]; other site
349521013861	Radical SAM superfamily; Region: Radical_SAM; pfam04055
349521013862	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521013863	FeS/SAM binding site; other site
349521013864	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521013865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
349521013866	active site
349521013867	intermolecular recognition site; other site
349521013868	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521013869	PAS domain; Region: PAS_9; pfam13426
349521013870	putative active site [active]
349521013871	heme pocket [chemical binding]; other site
349521013872	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521013873	metal binding site [ion binding]; metal-binding site
349521013874	active site
349521013875	I-site; other site
349521013876	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521013877	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
349521013878	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
349521013879	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
349521013880	phosphoserine phosphatase SerB; Region: serB; TIGR00338
349521013881	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521013882	motif II; other site
349521013883	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
349521013884	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
349521013885	CAP-like domain; other site
349521013886	active site
349521013887	primary dimer interface [polypeptide binding]; other site
349521013888	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349521013889	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349521013890	catalytic residue [active]
349521013891	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
349521013892	dimerization interface [polypeptide binding]; other site
349521013893	substrate binding site [chemical binding]; other site
349521013894	active site
349521013895	calcium binding site [ion binding]; other site
349521013896	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
349521013897	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521013898	FeS/SAM binding site; other site
349521013899	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
349521013900	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
349521013901	active site
349521013902	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349521013903	active site 2 [active]
349521013904	active site 1 [active]
349521013905	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
349521013906	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
349521013907	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
349521013908	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
349521013909	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349521013910	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521013911	ligand binding site [chemical binding]; other site
349521013912	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
349521013913	metal ion-dependent adhesion site (MIDAS); other site
349521013914	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
349521013915	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
349521013916	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
349521013917	ligand binding site [chemical binding]; other site
349521013918	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
349521013919	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
349521013920	Walker A/P-loop; other site
349521013921	ATP binding site [chemical binding]; other site
349521013922	Q-loop/lid; other site
349521013923	ABC transporter signature motif; other site
349521013924	Walker B; other site
349521013925	D-loop; other site
349521013926	H-loop/switch region; other site
349521013927	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
349521013928	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521013929	dimer interface [polypeptide binding]; other site
349521013930	conserved gate region; other site
349521013931	putative PBP binding loops; other site
349521013932	ABC-ATPase subunit interface; other site
349521013933	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
349521013934	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
349521013935	folate binding site [chemical binding]; other site
349521013936	NADP+ binding site [chemical binding]; other site
349521013937	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521013938	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521013939	substrate binding pocket [chemical binding]; other site
349521013940	membrane-bound complex binding site; other site
349521013941	hinge residues; other site
349521013942	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
349521013943	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
349521013944	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
349521013945	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
349521013946	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521013947	dimerization interface [polypeptide binding]; other site
349521013948	putative DNA binding site [nucleotide binding]; other site
349521013949	putative Zn2+ binding site [ion binding]; other site
349521013950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521013951	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
349521013952	putative substrate translocation pore; other site
349521013953	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521013954	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
349521013955	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521013956	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521013957	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521013958	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521013959	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
349521013960	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521013961	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521013962	Cupin domain; Region: Cupin_2; cl17218
349521013963	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521013964	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349521013965	Coenzyme A binding pocket [chemical binding]; other site
349521013966	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
349521013967	A new structural DNA glycosylase; Region: AlkD_like; cd06561
349521013968	active site
349521013969	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
349521013970	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521013971	substrate binding pocket [chemical binding]; other site
349521013972	membrane-bound complex binding site; other site
349521013973	hinge residues; other site
349521013974	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
349521013975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521013976	Walker A motif; other site
349521013977	ATP binding site [chemical binding]; other site
349521013978	Walker B motif; other site
349521013979	arginine finger; other site
349521013980	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521013981	phage shock protein A; Region: phageshock_pspA; TIGR02977
349521013982	phage shock protein B; Provisional; Region: pspB; PRK09458
349521013983	PspC domain; Region: PspC; cl00864
349521013984	phage shock protein C; Region: phageshock_pspC; TIGR02978
349521013985	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
349521013986	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
349521013987	PhnA protein; Region: PhnA; pfam03831
349521013988	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
349521013989	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
349521013990	diiron binding motif [ion binding]; other site
349521013991	Glyco_18 domain; Region: Glyco_18; smart00636
349521013992	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
349521013993	active site
349521013994	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
349521013995	aromatic chitin/cellulose binding site residues [chemical binding]; other site
349521013996	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
349521013997	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
349521013998	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
349521013999	putative active site [active]
349521014000	PAS fold; Region: PAS_4; pfam08448
349521014001	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521014002	putative active site [active]
349521014003	heme pocket [chemical binding]; other site
349521014004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521014005	dimer interface [polypeptide binding]; other site
349521014006	phosphorylation site [posttranslational modification]
349521014007	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
349521014008	Mg2+ binding site [ion binding]; other site
349521014009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521014010	ATP binding site [chemical binding]; other site
349521014011	G-X-G motif; other site
349521014012	Response regulator receiver domain; Region: Response_reg; pfam00072
349521014013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014014	active site
349521014015	phosphorylation site [posttranslational modification]
349521014016	intermolecular recognition site; other site
349521014017	dimerization interface [polypeptide binding]; other site
349521014018	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
349521014019	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521014020	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
349521014021	N-terminal plug; other site
349521014022	ligand-binding site [chemical binding]; other site
349521014023	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
349521014024	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
349521014025	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
349521014026	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
349521014027	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
349521014028	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
349521014029	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
349521014030	putative hemin binding site; other site
349521014031	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
349521014032	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521014033	ABC-ATPase subunit  interface; other site
349521014034	dimer interface [polypeptide binding]; other site
349521014035	putative PBP binding regions; other site
349521014036	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
349521014037	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
349521014038	Walker A/P-loop; other site
349521014039	ATP binding site [chemical binding]; other site
349521014040	Q-loop/lid; other site
349521014041	ABC transporter signature motif; other site
349521014042	Walker B; other site
349521014043	D-loop; other site
349521014044	H-loop/switch region; other site
349521014045	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521014046	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521014047	substrate binding pocket [chemical binding]; other site
349521014048	membrane-bound complex binding site; other site
349521014049	hinge residues; other site
349521014050	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349521014051	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
349521014052	Uncharacterized conserved protein [Function unknown]; Region: COG3791
349521014053	Peptidase M35 family; Region: M35_like; cl03449
349521014054	active site
349521014055	Zn binding site [ion binding]; other site
349521014056	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521014057	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521014058	SnoaL-like domain; Region: SnoaL_2; pfam12680
349521014059	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349521014060	Protein export membrane protein; Region: SecD_SecF; cl14618
349521014061	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521014062	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521014063	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521014064	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521014065	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521014066	EamA-like transporter family; Region: EamA; pfam00892
349521014067	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521014068	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521014069	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521014070	putative effector binding pocket; other site
349521014071	dimerization interface [polypeptide binding]; other site
349521014072	Uncharacterized conserved protein [Function unknown]; Region: COG1359
349521014073	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521014074	substrate binding pocket [chemical binding]; other site
349521014075	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521014076	membrane-bound complex binding site; other site
349521014077	hinge residues; other site
349521014078	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
349521014079	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
349521014080	putative substrate binding site [chemical binding]; other site
349521014081	nucleotide binding site [chemical binding]; other site
349521014082	nucleotide binding site [chemical binding]; other site
349521014083	homodimer interface [polypeptide binding]; other site
349521014084	ornithine carbamoyltransferase; Validated; Region: PRK02102
349521014085	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
349521014086	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
349521014087	arginine deiminase; Provisional; Region: PRK01388
349521014088	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
349521014089	CsbD-like; Region: CsbD; cl17424
349521014090	AAA ATPase domain; Region: AAA_16; pfam13191
349521014091	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
349521014092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521014093	Walker A motif; other site
349521014094	ATP binding site [chemical binding]; other site
349521014095	Walker B motif; other site
349521014096	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349521014097	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521014098	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349521014099	Walker A motif; other site
349521014100	ATP binding site [chemical binding]; other site
349521014101	Walker B motif; other site
349521014102	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
349521014103	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
349521014104	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521014105	Walker A motif; other site
349521014106	ATP binding site [chemical binding]; other site
349521014107	Walker B motif; other site
349521014108	arginine finger; other site
349521014109	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349521014110	Penicillin amidase; Region: Penicil_amidase; pfam01804
349521014111	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
349521014112	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
349521014113	active site
349521014114	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
349521014115	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
349521014116	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
349521014117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521014118	Walker A motif; other site
349521014119	ATP binding site [chemical binding]; other site
349521014120	Walker B motif; other site
349521014121	arginine finger; other site
349521014122	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
349521014123	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
349521014124	active site
349521014125	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
349521014126	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349521014127	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
349521014128	Trp docking motif [polypeptide binding]; other site
349521014129	active site
349521014130	PQQ-like domain; Region: PQQ_2; pfam13360
349521014131	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
349521014132	Pirin-related protein [General function prediction only]; Region: COG1741
349521014133	Pirin; Region: Pirin; pfam02678
349521014134	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
349521014135	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
349521014136	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
349521014137	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
349521014138	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
349521014139	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
349521014140	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
349521014141	dimer interface [polypeptide binding]; other site
349521014142	active site
349521014143	CoA binding pocket [chemical binding]; other site
349521014144	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349521014145	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521014146	NAD(P) binding site [chemical binding]; other site
349521014147	active site
349521014148	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
349521014149	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
349521014150	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
349521014151	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
349521014152	hypothetical protein; Provisional; Region: PRK06849
349521014153	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349521014154	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
349521014155	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
349521014156	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
349521014157	iron-sulfur cluster [ion binding]; other site
349521014158	[2Fe-2S] cluster binding site [ion binding]; other site
349521014159	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
349521014160	hydrophobic ligand binding site; other site
349521014161	Peptidase C80 family; Region: Peptidase_C80; pfam11713
349521014162	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
349521014163	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521014164	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
349521014165	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521014166	dimerization interface [polypeptide binding]; other site
349521014167	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
349521014168	LysE type translocator; Region: LysE; cl00565
349521014169	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
349521014170	NIPSNAP; Region: NIPSNAP; pfam07978
349521014171	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521014172	putative DNA binding site [nucleotide binding]; other site
349521014173	dimerization interface [polypeptide binding]; other site
349521014174	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
349521014175	active site
349521014176	CARDB; Region: CARDB; pfam07705
349521014177	Response regulator receiver domain; Region: Response_reg; pfam00072
349521014178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
349521014179	active site
349521014180	phosphorylation site [posttranslational modification]
349521014181	intermolecular recognition site; other site
349521014182	dimerization interface [polypeptide binding]; other site
349521014183	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
349521014184	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
349521014185	nucleotide binding site [chemical binding]; other site
349521014186	putative NEF/HSP70 interaction site [polypeptide binding]; other site
349521014187	SBD interface [polypeptide binding]; other site
349521014188	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
349521014189	HSP70 interaction site [polypeptide binding]; other site
349521014190	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
349521014191	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
349521014192	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
349521014193	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
349521014194	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
349521014195	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
349521014196	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
349521014197	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
349521014198	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349521014199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014200	active site
349521014201	phosphorylation site [posttranslational modification]
349521014202	intermolecular recognition site; other site
349521014203	dimerization interface [polypeptide binding]; other site
349521014204	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521014205	DNA binding residues [nucleotide binding]
349521014206	dimerization interface [polypeptide binding]; other site
349521014207	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521014208	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521014209	dimer interface [polypeptide binding]; other site
349521014210	phosphorylation site [posttranslational modification]
349521014211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521014212	ATP binding site [chemical binding]; other site
349521014213	Mg2+ binding site [ion binding]; other site
349521014214	G-X-G motif; other site
349521014215	Response regulator receiver domain; Region: Response_reg; pfam00072
349521014216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014217	active site
349521014218	phosphorylation site [posttranslational modification]
349521014219	intermolecular recognition site; other site
349521014220	dimerization interface [polypeptide binding]; other site
349521014221	Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357
349521014222	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
349521014223	catalytic residue [active]
349521014224	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
349521014225	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
349521014226	hydrophobic ligand binding site; other site
349521014227	haloalkane dehalogenase; Provisional; Region: PRK03204
349521014228	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
349521014229	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
349521014230	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
349521014231	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
349521014232	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
349521014233	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
349521014234	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
349521014235	metal ion-dependent adhesion site (MIDAS); other site
349521014236	MoxR-like ATPases [General function prediction only]; Region: COG0714
349521014237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521014238	Walker A motif; other site
349521014239	ATP binding site [chemical binding]; other site
349521014240	Walker B motif; other site
349521014241	arginine finger; other site
349521014242	SWIM zinc finger; Region: SWIM; pfam04434
349521014243	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349521014244	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521014245	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521014246	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
349521014247	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
349521014248	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521014249	Coenzyme A binding pocket [chemical binding]; other site
349521014250	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
349521014251	DNA-binding site [nucleotide binding]; DNA binding site
349521014252	RNA-binding motif; other site
349521014253	ribonuclease R; Region: RNase_R; TIGR02063
349521014254	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
349521014255	RNB domain; Region: RNB; pfam00773
349521014256	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
349521014257	RNA binding site [nucleotide binding]; other site
349521014258	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
349521014259	EamA-like transporter family; Region: EamA; pfam00892
349521014260	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349521014261	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521014262	ligand binding site [chemical binding]; other site
349521014263	flexible hinge region; other site
349521014264	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
349521014265	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
349521014266	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521014267	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
349521014268	DNA binding site [nucleotide binding]
349521014269	active site
349521014270	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
349521014271	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521014272	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521014273	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
349521014274	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
349521014275	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
349521014276	FOG: WD40 repeat [General function prediction only]; Region: COG2319
349521014277	structural tetrad; other site
349521014278	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
349521014279	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521014280	binding surface
349521014281	TPR motif; other site
349521014282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521014283	TPR motif; other site
349521014284	binding surface
349521014285	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
349521014286	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
349521014287	putative active site [active]
349521014288	putative metal binding site [ion binding]; other site
349521014289	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
349521014290	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
349521014291	DXD motif; other site
349521014292	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
349521014293	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
349521014294	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
349521014295	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521014296	DNA binding residues [nucleotide binding]
349521014297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
349521014298	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521014299	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
349521014300	dimer interface [polypeptide binding]; other site
349521014301	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
349521014302	SnoaL-like domain; Region: SnoaL_3; pfam13474
349521014303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
349521014304	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349521014305	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521014306	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521014307	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521014308	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
349521014309	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521014310	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349521014311	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521014312	Homeodomain-like domain; Region: HTH_23; pfam13384
349521014313	Winged helix-turn helix; Region: HTH_29; pfam13551
349521014314	Homeodomain-like domain; Region: HTH_32; pfam13565
349521014315	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
349521014316	putative catalytic site [active]
349521014317	putative phosphate binding site [ion binding]; other site
349521014318	putative metal binding site [ion binding]; other site
349521014319	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521014320	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521014321	non-specific DNA binding site [nucleotide binding]; other site
349521014322	salt bridge; other site
349521014323	sequence-specific DNA binding site [nucleotide binding]; other site
349521014324	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521014325	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521014326	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
349521014327	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349521014328	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349521014329	catalytic residues [active]
349521014330	catalytic nucleophile [active]
349521014331	Presynaptic Site I dimer interface [polypeptide binding]; other site
349521014332	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349521014333	Synaptic Flat tetramer interface [polypeptide binding]; other site
349521014334	Synaptic Site I dimer interface [polypeptide binding]; other site
349521014335	DNA binding site [nucleotide binding]
349521014336	Recombinase; Region: Recombinase; pfam07508
349521014337	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521014338	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349521014339	Coenzyme A binding pocket [chemical binding]; other site
349521014340	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
349521014341	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
349521014342	MPN+ (JAMM) motif; other site
349521014343	Zinc-binding site [ion binding]; other site
349521014344	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521014345	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
349521014346	DNA binding residues [nucleotide binding]
349521014347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349521014348	Integrase core domain; Region: rve; pfam00665
349521014349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349521014350	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
349521014351	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
349521014352	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521014353	Walker A motif; other site
349521014354	ATP binding site [chemical binding]; other site
349521014355	Walker B motif; other site
349521014356	arginine finger; other site
349521014357	HNH endonuclease; Region: HNH_2; pfam13391
349521014358	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521014359	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521014360	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
349521014361	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
349521014362	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
349521014363	Family description; Region: VCBS; pfam13517
349521014364	Family description; Region: VCBS; pfam13517
349521014365	Family description; Region: VCBS; pfam13517
349521014366	Family description; Region: VCBS; pfam13517
349521014367	RHS Repeat; Region: RHS_repeat; pfam05593
349521014368	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
349521014369	RHS Repeat; Region: RHS_repeat; pfam05593
349521014370	RHS Repeat; Region: RHS_repeat; pfam05593
349521014371	RHS Repeat; Region: RHS_repeat; pfam05593
349521014372	RHS Repeat; Region: RHS_repeat; pfam05593
349521014373	RHS Repeat; Region: RHS_repeat; pfam05593
349521014374	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521014375	RHS Repeat; Region: RHS_repeat; pfam05593
349521014376	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
349521014377	RHS Repeat; Region: RHS_repeat; pfam05593
349521014378	RHS Repeat; Region: RHS_repeat; pfam05593
349521014379	RHS Repeat; Region: RHS_repeat; pfam05593
349521014380	RHS Repeat; Region: RHS_repeat; pfam05593
349521014381	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
349521014382	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
349521014383	Putative phage tail protein; Region: Phage-tail_3; pfam13550
349521014384	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
349521014385	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
349521014386	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
349521014387	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
349521014388	sugar binding site [chemical binding]; other site
349521014389	Phage-related minor tail protein [Function unknown]; Region: COG5281
349521014390	tape measure domain; Region: tape_meas_nterm; TIGR02675
349521014391	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
349521014392	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
349521014393	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
349521014394	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
349521014395	tandem repeat interface [polypeptide binding]; other site
349521014396	oligomer interface [polypeptide binding]; other site
349521014397	active site residues [active]
349521014398	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
349521014399	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
349521014400	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
349521014401	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
349521014402	ParB-like nuclease domain; Region: ParBc; pfam02195
349521014403	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
349521014404	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
349521014405	DNA methylase; Region: N6_N4_Mtase; pfam01555
349521014406	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
349521014407	active site
349521014408	hypothetical protein; Validated; Region: PRK07078
349521014409	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
349521014410	active site
349521014411	metal binding site [ion binding]; metal-binding site
349521014412	interdomain interaction site; other site
349521014413	D5 N terminal like; Region: D5_N; smart00885
349521014414	AAA domain; Region: AAA_24; pfam13479
349521014415	Helix-turn-helix domain; Region: HTH_17; cl17695
349521014416	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521014417	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521014418	non-specific DNA binding site [nucleotide binding]; other site
349521014419	salt bridge; other site
349521014420	sequence-specific DNA binding site [nucleotide binding]; other site
349521014421	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
349521014422	Protein of unknown function (DUF2924); Region: DUF2924; pfam11149
349521014423	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349521014424	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
349521014425	catalytic residues [active]
349521014426	catalytic nucleophile [active]
349521014427	Presynaptic Site I dimer interface [polypeptide binding]; other site
349521014428	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
349521014429	Synaptic Flat tetramer interface [polypeptide binding]; other site
349521014430	Synaptic Site I dimer interface [polypeptide binding]; other site
349521014431	DNA binding site [nucleotide binding]
349521014432	Recombinase; Region: Recombinase; pfam07508
349521014433	sporulation sigma factor SigK; Reviewed; Region: PRK05803
349521014434	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
349521014435	MPN+ (JAMM) motif; other site
349521014436	Zinc-binding site [ion binding]; other site
349521014437	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
349521014438	3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147
349521014439	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
349521014440	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
349521014441	conserved hypothetical protein; Region: TIGR02270
349521014442	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
349521014443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521014444	Part of AAA domain; Region: AAA_19; pfam13245
349521014445	Walker A motif; other site
349521014446	ATP binding site [chemical binding]; other site
349521014447	Family description; Region: UvrD_C_2; pfam13538
349521014448	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
349521014449	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
349521014450	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521014451	ATP-binding site [chemical binding]; other site
349521014452	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
349521014453	nudix motif; other site
349521014454	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
349521014455	additional DNA contacts [nucleotide binding]; other site
349521014456	mismatch recognition site; other site
349521014457	active site
349521014458	zinc binding site [ion binding]; other site
349521014459	DNA intercalation site [nucleotide binding]; other site
349521014460	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
349521014461	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
349521014462	cofactor binding site; other site
349521014463	DNA binding site [nucleotide binding]
349521014464	substrate interaction site [chemical binding]; other site
349521014465	authentic frameshift; Zn-dependent protease with chaperone function; COG0501
349521014466	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
349521014467	Domain of unknown function (DUF4360); Region: DUF4360; pfam14273
349521014468	Uncharacterized conserved protein [Function unknown]; Region: COG0397
349521014469	hypothetical protein; Validated; Region: PRK00029
349521014470	PS-10 peptidase S37; Region: Peptidase_S37; pfam05576
349521014471	hypothetical protein; Reviewed; Region: PRK09588
349521014472	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521014473	dimerization interface [polypeptide binding]; other site
349521014474	putative Zn2+ binding site [ion binding]; other site
349521014475	putative DNA binding site [nucleotide binding]; other site
349521014476	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
349521014477	active site
349521014478	NTP binding site [chemical binding]; other site
349521014479	metal binding triad [ion binding]; metal-binding site
349521014480	antibiotic binding site [chemical binding]; other site
349521014481	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
349521014482	HsdM N-terminal domain; Region: HsdM_N; pfam12161
349521014483	RDD family; Region: RDD; pfam06271
349521014484	Synapsin, ATP binding domain; Region: Synapsin_C; pfam02750
349521014485	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
349521014486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521014487	Mg2+ binding site [ion binding]; other site
349521014488	G-X-G motif; other site
349521014489	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
349521014490	anchoring element; other site
349521014491	dimer interface [polypeptide binding]; other site
349521014492	ATP binding site [chemical binding]; other site
349521014493	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
349521014494	active site
349521014495	metal binding site [ion binding]; metal-binding site
349521014496	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
349521014497	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
349521014498	active site
349521014499	catalytic residues [active]
349521014500	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
349521014501	Amidase; Region: Amidase; pfam01425
349521014502	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
349521014503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014504	active site
349521014505	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
349521014506	phosphorylation site [posttranslational modification]
349521014507	intermolecular recognition site; other site
349521014508	dimerization interface [polypeptide binding]; other site
349521014509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014510	active site
349521014511	phosphorylation site [posttranslational modification]
349521014512	intermolecular recognition site; other site
349521014513	dimerization interface [polypeptide binding]; other site
349521014514	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521014515	metal binding site [ion binding]; metal-binding site
349521014516	active site
349521014517	I-site; other site
349521014518	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521014519	Hpt domain; Region: Hpt; pfam01627
349521014520	putative binding surface; other site
349521014521	active site
349521014522	Response regulator receiver domain; Region: Response_reg; pfam00072
349521014523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014524	active site
349521014525	phosphorylation site [posttranslational modification]
349521014526	intermolecular recognition site; other site
349521014527	dimerization interface [polypeptide binding]; other site
349521014528	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521014529	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521014530	metal binding site [ion binding]; metal-binding site
349521014531	active site
349521014532	I-site; other site
349521014533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014534	Response regulator receiver domain; Region: Response_reg; pfam00072
349521014535	active site
349521014536	phosphorylation site [posttranslational modification]
349521014537	intermolecular recognition site; other site
349521014538	dimerization interface [polypeptide binding]; other site
349521014539	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521014540	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521014541	membrane-bound complex binding site; other site
349521014542	hinge residues; other site
349521014543	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521014544	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521014545	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
349521014546	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
349521014547	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
349521014548	NAD(P) binding site [chemical binding]; other site
349521014549	substrate binding site [chemical binding]; other site
349521014550	homotetramer interface [polypeptide binding]; other site
349521014551	active site
349521014552	homodimer interface [polypeptide binding]; other site
349521014553	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
349521014554	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
349521014555	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
349521014556	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349521014557	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521014558	active site
349521014559	enoyl-CoA hydratase; Provisional; Region: PRK05995
349521014560	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521014561	substrate binding site [chemical binding]; other site
349521014562	oxyanion hole (OAH) forming residues; other site
349521014563	trimer interface [polypeptide binding]; other site
349521014564	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
349521014565	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349521014566	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
349521014567	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
349521014568	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349521014569	carboxyltransferase (CT) interaction site; other site
349521014570	biotinylation site [posttranslational modification]; other site
349521014571	short chain dehydrogenase; Provisional; Region: PRK08278
349521014572	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521014573	NAD(P) binding site [chemical binding]; other site
349521014574	active site
349521014575	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
349521014576	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521014577	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521014578	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
349521014579	acyl-activating enzyme (AAE) consensus motif; other site
349521014580	acyl-activating enzyme (AAE) consensus motif; other site
349521014581	putative AMP binding site [chemical binding]; other site
349521014582	putative active site [active]
349521014583	putative CoA binding site [chemical binding]; other site
349521014584	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
349521014585	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
349521014586	PAS domain S-box; Region: sensory_box; TIGR00229
349521014587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521014588	putative active site [active]
349521014589	heme pocket [chemical binding]; other site
349521014590	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521014591	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521014592	metal binding site [ion binding]; metal-binding site
349521014593	active site
349521014594	I-site; other site
349521014595	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521014596	DEAD-like helicases superfamily; Region: DEXDc; smart00487
349521014597	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
349521014598	ATP binding site [chemical binding]; other site
349521014599	Mg++ binding site [ion binding]; other site
349521014600	motif III; other site
349521014601	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521014602	nucleotide binding region [chemical binding]; other site
349521014603	ATP-binding site [chemical binding]; other site
349521014604	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
349521014605	putative RNA binding site [nucleotide binding]; other site
349521014606	WYL domain; Region: WYL; pfam13280
349521014607	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
349521014608	putative active site pocket [active]
349521014609	dimerization interface [polypeptide binding]; other site
349521014610	putative catalytic residue [active]
349521014611	YHYH protein; Region: YHYH; pfam14240
349521014612	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
349521014613	putative NAD(P) binding site [chemical binding]; other site
349521014614	homodimer interface [polypeptide binding]; other site
349521014615	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521014616	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521014617	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521014618	putative effector binding pocket; other site
349521014619	dimerization interface [polypeptide binding]; other site
349521014620	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
349521014621	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
349521014622	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349521014623	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
349521014624	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
349521014625	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
349521014626	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
349521014627	putative active site [active]
349521014628	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
349521014629	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349521014630	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
349521014631	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
349521014632	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
349521014633	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
349521014634	DctM-like transporters; Region: DctM; pfam06808
349521014635	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
349521014636	enoyl-CoA hydratase; Provisional; Region: PRK06563
349521014637	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349521014638	substrate binding site [chemical binding]; other site
349521014639	oxyanion hole (OAH) forming residues; other site
349521014640	trimer interface [polypeptide binding]; other site
349521014641	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
349521014642	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
349521014643	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
349521014644	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
349521014645	probable active site [active]
349521014646	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349521014647	CoenzymeA binding site [chemical binding]; other site
349521014648	subunit interaction site [polypeptide binding]; other site
349521014649	PHB binding site; other site
349521014650	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349521014651	CoenzymeA binding site [chemical binding]; other site
349521014652	subunit interaction site [polypeptide binding]; other site
349521014653	PHB binding site; other site
349521014654	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521014655	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521014656	phosphodiesterase; Provisional; Region: PRK12704
349521014657	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
349521014658	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
349521014659	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
349521014660	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521014661	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521014662	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349521014663	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521014664	active site
349521014665	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
349521014666	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
349521014667	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
349521014668	Dicarboxylate transport; Region: DctA-YdbH; cl14674
349521014669	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
349521014670	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
349521014671	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521014672	Walker A motif; other site
349521014673	ATP binding site [chemical binding]; other site
349521014674	Walker B motif; other site
349521014675	aromatic acid decarboxylase; Validated; Region: PRK05920
349521014676	Flavoprotein; Region: Flavoprotein; pfam02441
349521014677	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
349521014678	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349521014679	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349521014680	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349521014681	6-phosphofructokinase; Provisional; Region: PRK14072
349521014682	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
349521014683	active site
349521014684	ADP/pyrophosphate binding site [chemical binding]; other site
349521014685	dimerization interface [polypeptide binding]; other site
349521014686	allosteric effector site; other site
349521014687	fructose-1,6-bisphosphate binding site; other site
349521014688	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521014689	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521014690	WHG domain; Region: WHG; pfam13305
349521014691	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
349521014692	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
349521014693	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521014694	putative DNA binding site [nucleotide binding]; other site
349521014695	putative Zn2+ binding site [ion binding]; other site
349521014696	AsnC family; Region: AsnC_trans_reg; pfam01037
349521014697	putative transporter; Provisional; Region: PRK11021
349521014698	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
349521014699	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349521014700	Cysteine-rich domain; Region: CCG; pfam02754
349521014701	Cysteine-rich domain; Region: CCG; pfam02754
349521014702	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
349521014703	FAD binding domain; Region: FAD_binding_4; pfam01565
349521014704	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
349521014705	FAD binding domain; Region: FAD_binding_4; pfam01565
349521014706	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
349521014707	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521014708	substrate binding pocket [chemical binding]; other site
349521014709	membrane-bound complex binding site; other site
349521014710	hinge residues; other site
349521014711	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
349521014712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521014713	conserved gate region; other site
349521014714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521014715	dimer interface [polypeptide binding]; other site
349521014716	ABC-ATPase subunit interface; other site
349521014717	putative PBP binding loops; other site
349521014718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521014719	dimer interface [polypeptide binding]; other site
349521014720	conserved gate region; other site
349521014721	putative PBP binding loops; other site
349521014722	ABC-ATPase subunit interface; other site
349521014723	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
349521014724	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
349521014725	Walker A/P-loop; other site
349521014726	ATP binding site [chemical binding]; other site
349521014727	Q-loop/lid; other site
349521014728	ABC transporter signature motif; other site
349521014729	Walker B; other site
349521014730	D-loop; other site
349521014731	H-loop/switch region; other site
349521014732	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521014733	Coenzyme A binding pocket [chemical binding]; other site
349521014734	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
349521014735	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
349521014736	active site
349521014737	catalytic triad [active]
349521014738	oxyanion hole [active]
349521014739	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
349521014740	active site
349521014741	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521014742	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349521014743	active site
349521014744	ATP binding site [chemical binding]; other site
349521014745	substrate binding site [chemical binding]; other site
349521014746	activation loop (A-loop); other site
349521014747	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
349521014748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521014749	putative substrate translocation pore; other site
349521014750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521014751	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
349521014752	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521014753	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
349521014754	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
349521014755	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
349521014756	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
349521014757	[2Fe-2S] cluster binding site [ion binding]; other site
349521014758	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
349521014759	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
349521014760	[4Fe-4S] binding site [ion binding]; other site
349521014761	molybdopterin cofactor binding site; other site
349521014762	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
349521014763	molybdopterin cofactor binding site; other site
349521014764	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
349521014765	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
349521014766	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521014767	putative metal binding site [ion binding]; other site
349521014768	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521014769	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521014770	substrate binding pocket [chemical binding]; other site
349521014771	membrane-bound complex binding site; other site
349521014772	hinge residues; other site
349521014773	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
349521014774	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
349521014775	dimer interface [polypeptide binding]; other site
349521014776	active site
349521014777	Response regulator receiver domain; Region: Response_reg; pfam00072
349521014778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014779	active site
349521014780	phosphorylation site [posttranslational modification]
349521014781	intermolecular recognition site; other site
349521014782	dimerization interface [polypeptide binding]; other site
349521014783	Response regulator receiver domain; Region: Response_reg; pfam00072
349521014784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014785	active site
349521014786	phosphorylation site [posttranslational modification]
349521014787	intermolecular recognition site; other site
349521014788	dimerization interface [polypeptide binding]; other site
349521014789	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
349521014790	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
349521014791	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
349521014792	putative ligand binding site [chemical binding]; other site
349521014793	HAMP domain; Region: HAMP; pfam00672
349521014794	dimerization interface [polypeptide binding]; other site
349521014795	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521014796	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521014797	dimer interface [polypeptide binding]; other site
349521014798	putative CheW interface [polypeptide binding]; other site
349521014799	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349521014800	putative binding surface; other site
349521014801	active site
349521014802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521014803	ATP binding site [chemical binding]; other site
349521014804	Mg2+ binding site [ion binding]; other site
349521014805	G-X-G motif; other site
349521014806	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
349521014807	Response regulator receiver domain; Region: Response_reg; pfam00072
349521014808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521014809	active site
349521014810	phosphorylation site [posttranslational modification]
349521014811	intermolecular recognition site; other site
349521014812	dimerization interface [polypeptide binding]; other site
349521014813	CheW-like domain; Region: CheW; pfam01584
349521014814	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
349521014815	ABC1 family; Region: ABC1; cl17513
349521014816	lipoyl synthase; Provisional; Region: PRK05481
349521014817	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
349521014818	FeS/SAM binding site; other site
349521014819	lipoate-protein ligase B; Provisional; Region: PRK14342
349521014820	Protein of unknown function (DUF493); Region: DUF493; pfam04359
349521014821	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
349521014822	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
349521014823	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
349521014824	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
349521014825	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
349521014826	Sporulation related domain; Region: SPOR; pfam05036
349521014827	Transglycosylase SLT domain; Region: SLT_2; pfam13406
349521014828	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349521014829	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349521014830	catalytic residue [active]
349521014831	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
349521014832	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
349521014833	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
349521014834	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
349521014835	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
349521014836	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
349521014837	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
349521014838	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
349521014839	active site
349521014840	(T/H)XGH motif; other site
349521014841	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
349521014842	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
349521014843	putative catalytic cysteine [active]
349521014844	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521014845	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521014846	metal binding site [ion binding]; metal-binding site
349521014847	active site
349521014848	I-site; other site
349521014849	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521014850	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521014851	metal binding site [ion binding]; metal-binding site
349521014852	active site
349521014853	I-site; other site
349521014854	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
349521014855	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
349521014856	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
349521014857	active site
349521014858	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
349521014859	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
349521014860	Ion channel; Region: Ion_trans_2; pfam07885
349521014861	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349521014862	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521014863	ligand binding site [chemical binding]; other site
349521014864	flexible hinge region; other site
349521014865	HDOD domain; Region: HDOD; pfam08668
349521014866	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
349521014867	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
349521014868	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
349521014869	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521014870	ATP binding site [chemical binding]; other site
349521014871	putative Mg++ binding site [ion binding]; other site
349521014872	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521014873	nucleotide binding region [chemical binding]; other site
349521014874	ATP-binding site [chemical binding]; other site
349521014875	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
349521014876	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
349521014877	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
349521014878	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
349521014879	folate binding site [chemical binding]; other site
349521014880	NADP+ binding site [chemical binding]; other site
349521014881	thymidylate synthase; Reviewed; Region: thyA; PRK01827
349521014882	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
349521014883	dimerization interface [polypeptide binding]; other site
349521014884	active site
349521014885	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
349521014886	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349521014887	NRDE protein; Region: NRDE; cl01315
349521014888	PilZ domain; Region: PilZ; pfam07238
349521014889	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
349521014890	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
349521014891	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349521014892	ligand binding site [chemical binding]; other site
349521014893	flagellar motor protein PomA; Reviewed; Region: PRK08990
349521014894	flagellar motor protein MotA; Validated; Region: PRK08124
349521014895	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
349521014896	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
349521014897	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
349521014898	substrate binding pocket [chemical binding]; other site
349521014899	chain length determination region; other site
349521014900	substrate-Mg2+ binding site; other site
349521014901	catalytic residues [active]
349521014902	aspartate-rich region 1; other site
349521014903	active site lid residues [active]
349521014904	aspartate-rich region 2; other site
349521014905	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
349521014906	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
349521014907	TPP-binding site; other site
349521014908	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
349521014909	PYR/PP interface [polypeptide binding]; other site
349521014910	dimer interface [polypeptide binding]; other site
349521014911	TPP binding site [chemical binding]; other site
349521014912	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349521014913	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
349521014914	dimerization interface [polypeptide binding]; other site
349521014915	active site
349521014916	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
349521014917	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521014918	FeS/SAM binding site; other site
349521014919	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
349521014920	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
349521014921	MoaE interaction surface [polypeptide binding]; other site
349521014922	MoeB interaction surface [polypeptide binding]; other site
349521014923	thiocarboxylated glycine; other site
349521014924	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
349521014925	trimer interface [polypeptide binding]; other site
349521014926	dimer interface [polypeptide binding]; other site
349521014927	putative active site [active]
349521014928	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
349521014929	active site
349521014930	8-oxo-dGMP binding site [chemical binding]; other site
349521014931	nudix motif; other site
349521014932	metal binding site [ion binding]; metal-binding site
349521014933	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
349521014934	heterotetramer interface [polypeptide binding]; other site
349521014935	active site pocket [active]
349521014936	cleavage site
349521014937	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
349521014938	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
349521014939	SEC-C motif; Region: SEC-C; pfam02810
349521014940	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
349521014941	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521014942	Protein of unknown function (DUF721); Region: DUF721; pfam05258
349521014943	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
349521014944	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
349521014945	cell division protein FtsZ; Validated; Region: PRK09330
349521014946	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
349521014947	nucleotide binding site [chemical binding]; other site
349521014948	SulA interaction site; other site
349521014949	cell division protein FtsA; Region: ftsA; TIGR01174
349521014950	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
349521014951	nucleotide binding site [chemical binding]; other site
349521014952	Cell division protein FtsA; Region: FtsA; pfam14450
349521014953	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
349521014954	Cell division protein FtsQ; Region: FtsQ; pfam03799
349521014955	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
349521014956	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
349521014957	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349521014958	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
349521014959	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349521014960	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349521014961	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349521014962	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
349521014963	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
349521014964	active site
349521014965	homodimer interface [polypeptide binding]; other site
349521014966	cell division protein FtsW; Region: ftsW; TIGR02614
349521014967	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
349521014968	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349521014969	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349521014970	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
349521014971	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
349521014972	Mg++ binding site [ion binding]; other site
349521014973	putative catalytic motif [active]
349521014974	putative substrate binding site [chemical binding]; other site
349521014975	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
349521014976	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349521014977	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349521014978	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349521014979	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
349521014980	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349521014981	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349521014982	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349521014983	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
349521014984	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
349521014985	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
349521014986	Cell division protein FtsL; Region: FtsL; pfam04999
349521014987	MraW methylase family; Region: Methyltransf_5; pfam01795
349521014988	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
349521014989	cell division protein MraZ; Reviewed; Region: PRK00326
349521014990	MraZ protein; Region: MraZ; pfam02381
349521014991	MraZ protein; Region: MraZ; pfam02381
349521014992	Predicted methyltransferases [General function prediction only]; Region: COG0313
349521014993	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
349521014994	putative SAM binding site [chemical binding]; other site
349521014995	putative homodimer interface [polypeptide binding]; other site
349521014996	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
349521014997	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
349521014998	putative ligand binding site [chemical binding]; other site
349521014999	hypothetical protein; Reviewed; Region: PRK12497
349521015000	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
349521015001	dimer interface [polypeptide binding]; other site
349521015002	active site
349521015003	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
349521015004	stringent starvation protein A; Provisional; Region: sspA; PRK09481
349521015005	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521015006	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
349521015007	dimer interface [polypeptide binding]; other site
349521015008	N-terminal domain interface [polypeptide binding]; other site
349521015009	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
349521015010	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
349521015011	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
349521015012	Qi binding site; other site
349521015013	intrachain domain interface; other site
349521015014	interchain domain interface [polypeptide binding]; other site
349521015015	heme bH binding site [chemical binding]; other site
349521015016	heme bL binding site [chemical binding]; other site
349521015017	Qo binding site; other site
349521015018	interchain domain interface [polypeptide binding]; other site
349521015019	intrachain domain interface; other site
349521015020	Qi binding site; other site
349521015021	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
349521015022	Qo binding site; other site
349521015023	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
349521015024	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
349521015025	[2Fe-2S] cluster binding site [ion binding]; other site
349521015026	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
349521015027	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
349521015028	23S rRNA interface [nucleotide binding]; other site
349521015029	L3 interface [polypeptide binding]; other site
349521015030	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
349521015031	active site
349521015032	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
349521015033	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
349521015034	G1 box; other site
349521015035	putative GEF interaction site [polypeptide binding]; other site
349521015036	GTP/Mg2+ binding site [chemical binding]; other site
349521015037	Switch I region; other site
349521015038	G2 box; other site
349521015039	G3 box; other site
349521015040	Switch II region; other site
349521015041	G4 box; other site
349521015042	G5 box; other site
349521015043	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
349521015044	Predicted membrane protein [Function unknown]; Region: COG3235
349521015045	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521015046	Coenzyme A binding pocket [chemical binding]; other site
349521015047	2-isopropylmalate synthase; Validated; Region: PRK00915
349521015048	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
349521015049	active site
349521015050	catalytic residues [active]
349521015051	metal binding site [ion binding]; metal-binding site
349521015052	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
349521015053	von Willebrand factor type A domain; Region: VWA_2; pfam13519
349521015054	Helix-turn-helix domain; Region: HTH_28; pfam13518
349521015055	Winged helix-turn helix; Region: HTH_29; pfam13551
349521015056	Winged helix-turn helix; Region: HTH_33; pfam13592
349521015057	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521015058	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349521015059	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
349521015060	TMAO/DMSO reductase; Reviewed; Region: PRK05363
349521015061	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
349521015062	Moco binding site; other site
349521015063	metal coordination site [ion binding]; other site
349521015064	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
349521015065	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
349521015066	ketol-acid reductoisomerase; Provisional; Region: PRK05479
349521015067	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
349521015068	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
349521015069	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
349521015070	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
349521015071	putative valine binding site [chemical binding]; other site
349521015072	dimer interface [polypeptide binding]; other site
349521015073	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
349521015074	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
349521015075	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349521015076	PYR/PP interface [polypeptide binding]; other site
349521015077	dimer interface [polypeptide binding]; other site
349521015078	TPP binding site [chemical binding]; other site
349521015079	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349521015080	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
349521015081	TPP-binding site [chemical binding]; other site
349521015082	dimer interface [polypeptide binding]; other site
349521015083	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521015084	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
349521015085	Clp amino terminal domain; Region: Clp_N; pfam02861
349521015086	Clp amino terminal domain; Region: Clp_N; pfam02861
349521015087	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521015088	Walker A motif; other site
349521015089	ATP binding site [chemical binding]; other site
349521015090	Walker B motif; other site
349521015091	arginine finger; other site
349521015092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521015093	Walker A motif; other site
349521015094	ATP binding site [chemical binding]; other site
349521015095	Walker B motif; other site
349521015096	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
349521015097	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
349521015098	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
349521015099	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
349521015100	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349521015101	RNA binding surface [nucleotide binding]; other site
349521015102	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349521015103	active site
349521015104	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
349521015105	NAD synthetase; Provisional; Region: PRK13981
349521015106	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
349521015107	multimer interface [polypeptide binding]; other site
349521015108	active site
349521015109	catalytic triad [active]
349521015110	protein interface 1 [polypeptide binding]; other site
349521015111	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
349521015112	homodimer interface [polypeptide binding]; other site
349521015113	NAD binding pocket [chemical binding]; other site
349521015114	ATP binding pocket [chemical binding]; other site
349521015115	Mg binding site [ion binding]; other site
349521015116	active-site loop [active]
349521015117	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349521015118	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521015119	dimer interface [polypeptide binding]; other site
349521015120	phosphorylation site [posttranslational modification]
349521015121	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521015122	ATP binding site [chemical binding]; other site
349521015123	Mg2+ binding site [ion binding]; other site
349521015124	G-X-G motif; other site
349521015125	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349521015126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521015127	active site
349521015128	phosphorylation site [posttranslational modification]
349521015129	intermolecular recognition site; other site
349521015130	dimerization interface [polypeptide binding]; other site
349521015131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521015132	Walker A motif; other site
349521015133	ATP binding site [chemical binding]; other site
349521015134	Walker B motif; other site
349521015135	arginine finger; other site
349521015136	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349521015137	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
349521015138	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
349521015139	Type II transport protein GspH; Region: GspH; pfam12019
349521015140	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
349521015141	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
349521015142	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
349521015143	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
349521015144	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
349521015145	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
349521015146	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
349521015147	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
349521015148	Type II transport protein GspH; Region: GspH; pfam12019
349521015149	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
349521015150	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
349521015151	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
349521015152	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
349521015153	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
349521015154	lipoprotein signal peptidase; Provisional; Region: PRK14787
349521015155	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
349521015156	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349521015157	active site
349521015158	HIGH motif; other site
349521015159	nucleotide binding site [chemical binding]; other site
349521015160	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
349521015161	active site
349521015162	KMSKS motif; other site
349521015163	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
349521015164	tRNA binding surface [nucleotide binding]; other site
349521015165	anticodon binding site; other site
349521015166	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
349521015167	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
349521015168	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
349521015169	Riboflavin kinase; Region: Flavokinase; smart00904
349521015170	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
349521015171	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
349521015172	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
349521015173	gamma-glutamyl kinase; Provisional; Region: PRK05429
349521015174	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
349521015175	nucleotide binding site [chemical binding]; other site
349521015176	homotetrameric interface [polypeptide binding]; other site
349521015177	putative phosphate binding site [ion binding]; other site
349521015178	putative allosteric binding site; other site
349521015179	PUA domain; Region: PUA; pfam01472
349521015180	GTPase CgtA; Reviewed; Region: obgE; PRK12298
349521015181	GTP1/OBG; Region: GTP1_OBG; pfam01018
349521015182	Obg GTPase; Region: Obg; cd01898
349521015183	G1 box; other site
349521015184	GTP/Mg2+ binding site [chemical binding]; other site
349521015185	Switch I region; other site
349521015186	G2 box; other site
349521015187	G3 box; other site
349521015188	Switch II region; other site
349521015189	G4 box; other site
349521015190	G5 box; other site
349521015191	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
349521015192	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
349521015193	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
349521015194	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
349521015195	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
349521015196	substrate binding pocket [chemical binding]; other site
349521015197	chain length determination region; other site
349521015198	substrate-Mg2+ binding site; other site
349521015199	catalytic residues [active]
349521015200	aspartate-rich region 1; other site
349521015201	active site lid residues [active]
349521015202	aspartate-rich region 2; other site
349521015203	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
349521015204	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
349521015205	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
349521015206	AMMECR1; Region: AMMECR1; pfam01871
349521015207	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
349521015208	putative ligand binding pocket/active site [active]
349521015209	putative metal binding site [ion binding]; other site
349521015210	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
349521015211	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
349521015212	tetramer interfaces [polypeptide binding]; other site
349521015213	binuclear metal-binding site [ion binding]; other site
349521015214	thiamine monophosphate kinase; Provisional; Region: PRK05731
349521015215	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
349521015216	ATP binding site [chemical binding]; other site
349521015217	dimerization interface [polypeptide binding]; other site
349521015218	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
349521015219	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
349521015220	homopentamer interface [polypeptide binding]; other site
349521015221	active site
349521015222	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
349521015223	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
349521015224	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
349521015225	dimerization interface [polypeptide binding]; other site
349521015226	active site
349521015227	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
349521015228	Lumazine binding domain; Region: Lum_binding; pfam00677
349521015229	Lumazine binding domain; Region: Lum_binding; pfam00677
349521015230	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
349521015231	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
349521015232	catalytic motif [active]
349521015233	Zn binding site [ion binding]; other site
349521015234	RibD C-terminal domain; Region: RibD_C; cl17279
349521015235	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
349521015236	ATP cone domain; Region: ATP-cone; pfam03477
349521015237	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
349521015238	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
349521015239	dimer interface [polypeptide binding]; other site
349521015240	active site
349521015241	glycine-pyridoxal phosphate binding site [chemical binding]; other site
349521015242	folate binding site [chemical binding]; other site
349521015243	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
349521015244	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521015245	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521015246	ABC transporter; Region: ABC_tran_2; pfam12848
349521015247	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349521015248	PilZ domain; Region: PilZ; pfam07238
349521015249	DNA repair protein RadA; Provisional; Region: PRK11823
349521015250	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
349521015251	Walker A motif/ATP binding site; other site
349521015252	ATP binding site [chemical binding]; other site
349521015253	Walker B motif; other site
349521015254	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
349521015255	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
349521015256	substrate binding site [chemical binding]; other site
349521015257	active site
349521015258	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
349521015259	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349521015260	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349521015261	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521015262	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
349521015263	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
349521015264	active site
349521015265	dimer interface [polypeptide binding]; other site
349521015266	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
349521015267	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
349521015268	active site
349521015269	FMN binding site [chemical binding]; other site
349521015270	substrate binding site [chemical binding]; other site
349521015271	3Fe-4S cluster binding site [ion binding]; other site
349521015272	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
349521015273	domain interface; other site
349521015274	AAA domain; Region: AAA_22; pfam13401
349521015275	Sporulation related domain; Region: SPOR; pfam05036
349521015276	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
349521015277	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
349521015278	active site
349521015279	dimer interface [polypeptide binding]; other site
349521015280	metal binding site [ion binding]; metal-binding site
349521015281	shikimate kinase; Reviewed; Region: aroK; PRK00131
349521015282	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
349521015283	ADP binding site [chemical binding]; other site
349521015284	magnesium binding site [ion binding]; other site
349521015285	putative shikimate binding site; other site
349521015286	AMIN domain; Region: AMIN; pfam11741
349521015287	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
349521015288	Secretin and TonB N terminus short domain; Region: STN; smart00965
349521015289	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349521015290	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349521015291	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
349521015292	Pilus assembly protein, PilP; Region: PilP; pfam04351
349521015293	Pilus assembly protein, PilO; Region: PilO; pfam04350
349521015294	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
349521015295	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
349521015296	Competence protein A; Region: Competence_A; pfam11104
349521015297	Cell division protein FtsA; Region: FtsA; pfam14450
349521015298	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
349521015299	Transglycosylase; Region: Transgly; pfam00912
349521015300	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
349521015301	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
349521015302	Malic enzyme, N-terminal domain; Region: malic; pfam00390
349521015303	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
349521015304	putative NAD(P) binding site [chemical binding]; other site
349521015305	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
349521015306	primosome assembly protein PriA; Validated; Region: PRK05580
349521015307	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521015308	ATP binding site [chemical binding]; other site
349521015309	putative Mg++ binding site [ion binding]; other site
349521015310	helicase superfamily c-terminal domain; Region: HELICc; smart00490
349521015311	ATP-binding site [chemical binding]; other site
349521015312	Sporulation related domain; Region: SPOR; pfam05036
349521015313	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
349521015314	active site
349521015315	HslU subunit interaction site [polypeptide binding]; other site
349521015316	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
349521015317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521015318	Walker A motif; other site
349521015319	ATP binding site [chemical binding]; other site
349521015320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521015321	Walker B motif; other site
349521015322	arginine finger; other site
349521015323	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349521015324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
349521015325	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
349521015326	nucleophile elbow; other site
349521015327	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
349521015328	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
349521015329	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
349521015330	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349521015331	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
349521015332	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
349521015333	putative active site [active]
349521015334	Ap4A binding site [chemical binding]; other site
349521015335	nudix motif; other site
349521015336	putative metal binding site [ion binding]; other site
349521015337	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
349521015338	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
349521015339	Imelysin; Region: Peptidase_M75; pfam09375
349521015340	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
349521015341	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
349521015342	putative RNA binding site [nucleotide binding]; other site
349521015343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521015344	S-adenosylmethionine binding site [chemical binding]; other site
349521015345	HDOD domain; Region: HDOD; pfam08668
349521015346	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
349521015347	lipoyl attachment site [posttranslational modification]; other site
349521015348	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
349521015349	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521015350	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
349521015351	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521015352	active site
349521015353	metal binding site [ion binding]; metal-binding site
349521015354	hexamer interface [polypeptide binding]; other site
349521015355	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
349521015356	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
349521015357	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
349521015358	dimer interface [polypeptide binding]; other site
349521015359	ADP-ribose binding site [chemical binding]; other site
349521015360	active site
349521015361	nudix motif; other site
349521015362	metal binding site [ion binding]; metal-binding site
349521015363	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
349521015364	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
349521015365	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
349521015366	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349521015367	FAD dependent oxidoreductase; Region: DAO; pfam01266
349521015368	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349521015369	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349521015370	active site
349521015371	catalytic tetrad [active]
349521015372	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095
349521015373	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521015374	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521015375	metal binding site [ion binding]; metal-binding site
349521015376	active site
349521015377	I-site; other site
349521015378	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521015379	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
349521015380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521015381	active site
349521015382	phosphorylation site [posttranslational modification]
349521015383	intermolecular recognition site; other site
349521015384	dimerization interface [polypeptide binding]; other site
349521015385	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521015386	metal binding site [ion binding]; metal-binding site
349521015387	active site
349521015388	I-site; other site
349521015389	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
349521015390	Dehydroquinase class II; Region: DHquinase_II; pfam01220
349521015391	trimer interface [polypeptide binding]; other site
349521015392	active site
349521015393	dimer interface [polypeptide binding]; other site
349521015394	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
349521015395	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349521015396	carboxyltransferase (CT) interaction site; other site
349521015397	biotinylation site [posttranslational modification]; other site
349521015398	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
349521015399	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349521015400	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
349521015401	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
349521015402	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
349521015403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349521015404	S-adenosylmethionine binding site [chemical binding]; other site
349521015405	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
349521015406	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
349521015407	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
349521015408	FMN binding site [chemical binding]; other site
349521015409	active site
349521015410	catalytic residues [active]
349521015411	substrate binding site [chemical binding]; other site
349521015412	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
349521015413	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
349521015414	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
349521015415	purine monophosphate binding site [chemical binding]; other site
349521015416	dimer interface [polypeptide binding]; other site
349521015417	putative catalytic residues [active]
349521015418	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
349521015419	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
349521015420	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
349521015421	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
349521015422	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
349521015423	PAS domain S-box; Region: sensory_box; TIGR00229
349521015424	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521015425	putative active site [active]
349521015426	heme pocket [chemical binding]; other site
349521015427	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
349521015428	PAS domain S-box; Region: sensory_box; TIGR00229
349521015429	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521015430	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
349521015431	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
349521015432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349521015433	PAS domain; Region: PAS_9; pfam13426
349521015434	putative active site [active]
349521015435	heme pocket [chemical binding]; other site
349521015436	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521015437	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521015438	metal binding site [ion binding]; metal-binding site
349521015439	active site
349521015440	I-site; other site
349521015441	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521015442	Response regulator receiver domain; Region: Response_reg; pfam00072
349521015443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521015444	active site
349521015445	phosphorylation site [posttranslational modification]
349521015446	intermolecular recognition site; other site
349521015447	dimerization interface [polypeptide binding]; other site
349521015448	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
349521015449	tetramer interface [polypeptide binding]; other site
349521015450	dimer interface [polypeptide binding]; other site
349521015451	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
349521015452	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349521015453	EamA-like transporter family; Region: EamA; pfam00892
349521015454	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521015455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521015456	active site
349521015457	phosphorylation site [posttranslational modification]
349521015458	intermolecular recognition site; other site
349521015459	Response regulator receiver domain; Region: Response_reg; pfam00072
349521015460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521015461	active site
349521015462	phosphorylation site [posttranslational modification]
349521015463	intermolecular recognition site; other site
349521015464	dimerization interface [polypeptide binding]; other site
349521015465	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521015466	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521015467	metal binding site [ion binding]; metal-binding site
349521015468	active site
349521015469	I-site; other site
349521015470	Bacterial Ig-like domain; Region: Big_5; pfam13205
349521015471	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
349521015472	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
349521015473	dimer interface [polypeptide binding]; other site
349521015474	active site
349521015475	catalytic residue [active]
349521015476	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349521015477	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521015478	active site
349521015479	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349521015480	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
349521015481	phosphoenolpyruvate synthase; Validated; Region: PRK06241
349521015482	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349521015483	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
349521015484	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
349521015485	TPP-binding site [chemical binding]; other site
349521015486	Predicted dehydrogenase [General function prediction only]; Region: COG5322
349521015487	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349521015488	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
349521015489	inhibitor-cofactor binding pocket; inhibition site
349521015490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521015491	catalytic residue [active]
349521015492	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
349521015493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521015494	S-adenosylmethionine binding site [chemical binding]; other site
349521015495	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
349521015496	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
349521015497	substrate-cofactor binding pocket; other site
349521015498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521015499	catalytic residue [active]
349521015500	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
349521015501	AMP-binding enzyme; Region: AMP-binding; pfam00501
349521015502	acyl-activating enzyme (AAE) consensus motif; other site
349521015503	AMP binding site [chemical binding]; other site
349521015504	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521015505	active site
349521015506	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
349521015507	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
349521015508	active site
349521015509	REDY-like protein HapK; Region: HapK; pfam11639
349521015510	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
349521015511	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
349521015512	Nitroreductase family; Region: Nitroreductase; pfam00881
349521015513	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
349521015514	RNA ligase; Region: RNA_ligase; pfam09414
349521015515	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
349521015516	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
349521015517	dimerization interface [polypeptide binding]; other site
349521015518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521015519	dimer interface [polypeptide binding]; other site
349521015520	phosphorylation site [posttranslational modification]
349521015521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521015522	ATP binding site [chemical binding]; other site
349521015523	Mg2+ binding site [ion binding]; other site
349521015524	G-X-G motif; other site
349521015525	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521015526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521015527	active site
349521015528	phosphorylation site [posttranslational modification]
349521015529	intermolecular recognition site; other site
349521015530	dimerization interface [polypeptide binding]; other site
349521015531	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521015532	DNA binding site [nucleotide binding]
349521015533	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
349521015534	Phage Tail Collar Domain; Region: Collar; pfam07484
349521015535	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
349521015536	Phage Tail Collar Domain; Region: Collar; pfam07484
349521015537	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
349521015538	Phage Tail Collar Domain; Region: Collar; pfam07484
349521015539	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
349521015540	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
349521015541	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
349521015542	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
349521015543	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
349521015544	active site
349521015545	dimer interface [polypeptide binding]; other site
349521015546	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
349521015547	Ligand Binding Site [chemical binding]; other site
349521015548	Molecular Tunnel; other site
349521015549	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349521015550	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521015551	Walker A/P-loop; other site
349521015552	ATP binding site [chemical binding]; other site
349521015553	Q-loop/lid; other site
349521015554	ABC transporter signature motif; other site
349521015555	Walker B; other site
349521015556	D-loop; other site
349521015557	H-loop/switch region; other site
349521015558	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349521015559	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
349521015560	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
349521015561	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349521015562	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
349521015563	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
349521015564	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521015565	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521015566	substrate binding pocket [chemical binding]; other site
349521015567	membrane-bound complex binding site; other site
349521015568	hinge residues; other site
349521015569	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521015570	dimerization interface [polypeptide binding]; other site
349521015571	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521015572	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521015573	dimer interface [polypeptide binding]; other site
349521015574	putative CheW interface [polypeptide binding]; other site
349521015575	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
349521015576	Chromatin remodelling complex Rsc7/Swp82 subunit; Region: CRC_subunit; pfam08624
349521015577	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
349521015578	Cupin domain; Region: Cupin_2; cl17218
349521015579	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521015580	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521015581	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
349521015582	dimerization interface [polypeptide binding]; other site
349521015583	putative active cleft [active]
349521015584	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349521015585	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
349521015586	putative substrate binding site [chemical binding]; other site
349521015587	putative ATP binding site [chemical binding]; other site
349521015588	Cupin domain; Region: Cupin_2; cl17218
349521015589	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521015590	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521015591	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521015592	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
349521015593	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349521015594	Walker A/P-loop; other site
349521015595	ATP binding site [chemical binding]; other site
349521015596	Q-loop/lid; other site
349521015597	ABC transporter signature motif; other site
349521015598	Walker B; other site
349521015599	D-loop; other site
349521015600	H-loop/switch region; other site
349521015601	TOBE domain; Region: TOBE; pfam03459
349521015602	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349521015603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521015604	dimer interface [polypeptide binding]; other site
349521015605	conserved gate region; other site
349521015606	putative PBP binding loops; other site
349521015607	ABC-ATPase subunit interface; other site
349521015608	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
349521015609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521015610	dimer interface [polypeptide binding]; other site
349521015611	conserved gate region; other site
349521015612	putative PBP binding loops; other site
349521015613	ABC-ATPase subunit interface; other site
349521015614	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521015615	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521015616	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521015617	dimerization interface [polypeptide binding]; other site
349521015618	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521015619	dimer interface [polypeptide binding]; other site
349521015620	phosphorylation site [posttranslational modification]
349521015621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521015622	ATP binding site [chemical binding]; other site
349521015623	Mg2+ binding site [ion binding]; other site
349521015624	G-X-G motif; other site
349521015625	osmolarity response regulator; Provisional; Region: ompR; PRK09468
349521015626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521015627	active site
349521015628	phosphorylation site [posttranslational modification]
349521015629	intermolecular recognition site; other site
349521015630	dimerization interface [polypeptide binding]; other site
349521015631	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521015632	DNA binding site [nucleotide binding]
349521015633	Predicted membrane protein [Function unknown]; Region: COG2860
349521015634	UPF0126 domain; Region: UPF0126; pfam03458
349521015635	UPF0126 domain; Region: UPF0126; pfam03458
349521015636	LysE type translocator; Region: LysE; cl00565
349521015637	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
349521015638	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
349521015639	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
349521015640	hypothetical protein; Provisional; Region: PRK11239
349521015641	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349521015642	HSP70 interaction site [polypeptide binding]; other site
349521015643	von Willebrand factor type A domain; Region: VWA_2; pfam13519
349521015644	prephenate dehydratase; Provisional; Region: PRK11899
349521015645	Prephenate dehydratase; Region: PDT; pfam00800
349521015646	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
349521015647	putative L-Phe binding site [chemical binding]; other site
349521015648	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349521015649	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
349521015650	active site
349521015651	dimerization interface [polypeptide binding]; other site
349521015652	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
349521015653	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
349521015654	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521015655	substrate binding pocket [chemical binding]; other site
349521015656	membrane-bound complex binding site; other site
349521015657	hinge residues; other site
349521015658	division inhibitor protein; Provisional; Region: slmA; PRK09480
349521015659	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521015660	Protein of unknown function (DUF423); Region: DUF423; pfam04241
349521015661	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
349521015662	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
349521015663	active site
349521015664	metal binding site [ion binding]; metal-binding site
349521015665	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
349521015666	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
349521015667	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521015668	S-adenosylmethionine binding site [chemical binding]; other site
349521015669	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
349521015670	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
349521015671	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
349521015672	SurA N-terminal domain; Region: SurA_N; pfam09312
349521015673	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
349521015674	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
349521015675	organic solvent tolerance protein; Provisional; Region: PRK04423
349521015676	OstA-like protein; Region: OstA; cl00844
349521015677	Organic solvent tolerance protein; Region: OstA_C; pfam04453
349521015678	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
349521015679	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
349521015680	active site
349521015681	nucleophile elbow; other site
349521015682	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
349521015683	Phosphotransferase enzyme family; Region: APH; pfam01636
349521015684	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
349521015685	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
349521015686	Substrate binding site; other site
349521015687	metal-binding site
349521015688	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
349521015689	tellurium resistance terB-like protein; Region: terB_like; cl11965
349521015690	metal binding site [ion binding]; metal-binding site
349521015691	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349521015692	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
349521015693	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
349521015694	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
349521015695	substrate binding site [chemical binding]; other site
349521015696	hexamer interface [polypeptide binding]; other site
349521015697	metal binding site [ion binding]; metal-binding site
349521015698	phosphoglycolate phosphatase; Provisional; Region: PRK13222
349521015699	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
349521015700	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521015701	motif II; other site
349521015702	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
349521015703	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
349521015704	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
349521015705	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
349521015706	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521015707	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521015708	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
349521015709	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
349521015710	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521015711	ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252
349521015712	Walker A/P-loop; other site
349521015713	ATP binding site [chemical binding]; other site
349521015714	Q-loop/lid; other site
349521015715	ABC transporter signature motif; other site
349521015716	Walker B; other site
349521015717	D-loop; other site
349521015718	H-loop/switch region; other site
349521015719	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
349521015720	Double zinc ribbon; Region: DZR; pfam12773
349521015721	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521015722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521015723	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349521015724	dimerization interface [polypeptide binding]; other site
349521015725	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
349521015726	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349521015727	FAD binding site [chemical binding]; other site
349521015728	substrate binding pocket [chemical binding]; other site
349521015729	catalytic base [active]
349521015730	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
349521015731	tetramer interface [polypeptide binding]; other site
349521015732	TPP-binding site [chemical binding]; other site
349521015733	heterodimer interface [polypeptide binding]; other site
349521015734	phosphorylation loop region [posttranslational modification]
349521015735	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
349521015736	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
349521015737	alpha subunit interface [polypeptide binding]; other site
349521015738	TPP binding site [chemical binding]; other site
349521015739	heterodimer interface [polypeptide binding]; other site
349521015740	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349521015741	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
349521015742	anthranilate synthase component I; Provisional; Region: PRK13565
349521015743	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
349521015744	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
349521015745	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
349521015746	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
349521015747	glutamine binding [chemical binding]; other site
349521015748	catalytic triad [active]
349521015749	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
349521015750	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
349521015751	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
349521015752	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
349521015753	active site
349521015754	ribulose/triose binding site [chemical binding]; other site
349521015755	phosphate binding site [ion binding]; other site
349521015756	substrate (anthranilate) binding pocket [chemical binding]; other site
349521015757	product (indole) binding pocket [chemical binding]; other site
349521015758	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
349521015759	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521015760	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
349521015761	dimerization interface [polypeptide binding]; other site
349521015762	substrate binding pocket [chemical binding]; other site
349521015763	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
349521015764	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
349521015765	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521015766	ligand binding site [chemical binding]; other site
349521015767	flexible hinge region; other site
349521015768	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349521015769	putative switch regulator; other site
349521015770	non-specific DNA interactions [nucleotide binding]; other site
349521015771	DNA binding site [nucleotide binding]
349521015772	sequence specific DNA binding site [nucleotide binding]; other site
349521015773	putative cAMP binding site [chemical binding]; other site
349521015774	OsmC-like protein; Region: OsmC; cl00767
349521015775	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
349521015776	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
349521015777	phosphoribulokinase; Provisional; Region: PRK15453
349521015778	Ycf46; Provisional; Region: ycf46; CHL00195
349521015779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521015780	Walker A motif; other site
349521015781	ATP binding site [chemical binding]; other site
349521015782	Walker B motif; other site
349521015783	arginine finger; other site
349521015784	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
349521015785	intermolecular salt bridges; other site
349521015786	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
349521015787	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
349521015788	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
349521015789	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
349521015790	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
349521015791	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349521015792	fructuronate transporter; Provisional; Region: PRK10034; cl15264
349521015793	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349521015794	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
349521015795	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
349521015796	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
349521015797	Walker A motif; other site
349521015798	ATP binding site [chemical binding]; other site
349521015799	Walker B motif; other site
349521015800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521015801	TPR motif; other site
349521015802	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
349521015803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521015804	Walker A motif; other site
349521015805	ATP binding site [chemical binding]; other site
349521015806	Walker B motif; other site
349521015807	arginine finger; other site
349521015808	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
349521015809	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
349521015810	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349521015811	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
349521015812	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
349521015813	serine O-acetyltransferase; Region: cysE; TIGR01172
349521015814	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
349521015815	trimer interface [polypeptide binding]; other site
349521015816	active site
349521015817	substrate binding site [chemical binding]; other site
349521015818	CoA binding site [chemical binding]; other site
349521015819	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
349521015820	trimer interface [polypeptide binding]; other site
349521015821	active site
349521015822	substrate binding site [chemical binding]; other site
349521015823	CoA binding site [chemical binding]; other site
349521015824	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
349521015825	Chorismate lyase; Region: Chor_lyase; cl01230
349521015826	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
349521015827	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521015828	acyl-activating enzyme (AAE) consensus motif; other site
349521015829	AMP binding site [chemical binding]; other site
349521015830	active site
349521015831	CoA binding site [chemical binding]; other site
349521015832	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
349521015833	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
349521015834	Ligand binding site; other site
349521015835	Putative Catalytic site; other site
349521015836	DXD motif; other site
349521015837	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
349521015838	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
349521015839	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
349521015840	ligand-binding site [chemical binding]; other site
349521015841	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349521015842	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349521015843	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
349521015844	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
349521015845	trimer interface [polypeptide binding]; other site
349521015846	active site
349521015847	substrate binding site [chemical binding]; other site
349521015848	CoA binding site [chemical binding]; other site
349521015849	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
349521015850	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521015851	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521015852	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521015853	Outer membrane efflux protein; Region: OEP; pfam02321
349521015854	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
349521015855	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
349521015856	Bacterial transcriptional activator domain; Region: BTAD; smart01043
349521015857	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
349521015858	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
349521015859	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
349521015860	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
349521015861	Substrate binding site; other site
349521015862	Mg++ binding site; other site
349521015863	metal-binding site
349521015864	Mg++ binding site; other site
349521015865	metal-binding site
349521015866	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
349521015867	dimer interface [polypeptide binding]; other site
349521015868	active site
349521015869	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
349521015870	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
349521015871	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349521015872	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
349521015873	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
349521015874	dimer interface [polypeptide binding]; other site
349521015875	ssDNA binding site [nucleotide binding]; other site
349521015876	tetramer (dimer of dimers) interface [polypeptide binding]; other site
349521015877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521015878	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521015879	putative substrate translocation pore; other site
349521015880	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
349521015881	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
349521015882	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
349521015883	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
349521015884	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
349521015885	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
349521015886	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
349521015887	alphaNTD homodimer interface [polypeptide binding]; other site
349521015888	alphaNTD - beta interaction site [polypeptide binding]; other site
349521015889	alphaNTD - beta' interaction site [polypeptide binding]; other site
349521015890	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
349521015891	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
349521015892	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
349521015893	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349521015894	RNA binding surface [nucleotide binding]; other site
349521015895	30S ribosomal protein S11; Validated; Region: PRK05309
349521015896	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
349521015897	30S ribosomal protein S13; Region: bact_S13; TIGR03631
349521015898	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
349521015899	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
349521015900	SecY translocase; Region: SecY; pfam00344
349521015901	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
349521015902	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
349521015903	23S rRNA binding site [nucleotide binding]; other site
349521015904	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
349521015905	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
349521015906	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
349521015907	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
349521015908	5S rRNA interface [nucleotide binding]; other site
349521015909	L27 interface [polypeptide binding]; other site
349521015910	23S rRNA interface [nucleotide binding]; other site
349521015911	L5 interface [polypeptide binding]; other site
349521015912	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
349521015913	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
349521015914	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
349521015915	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
349521015916	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
349521015917	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
349521015918	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
349521015919	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
349521015920	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
349521015921	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
349521015922	RNA binding site [nucleotide binding]; other site
349521015923	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
349521015924	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
349521015925	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
349521015926	23S rRNA interface [nucleotide binding]; other site
349521015927	putative translocon interaction site; other site
349521015928	signal recognition particle (SRP54) interaction site; other site
349521015929	L23 interface [polypeptide binding]; other site
349521015930	trigger factor interaction site; other site
349521015931	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
349521015932	23S rRNA interface [nucleotide binding]; other site
349521015933	5S rRNA interface [nucleotide binding]; other site
349521015934	putative antibiotic binding site [chemical binding]; other site
349521015935	L25 interface [polypeptide binding]; other site
349521015936	L27 interface [polypeptide binding]; other site
349521015937	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
349521015938	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
349521015939	G-X-X-G motif; other site
349521015940	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
349521015941	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
349521015942	protein-rRNA interface [nucleotide binding]; other site
349521015943	putative translocon binding site; other site
349521015944	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
349521015945	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
349521015946	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
349521015947	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
349521015948	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
349521015949	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
349521015950	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
349521015951	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
349521015952	elongation factor Tu; Reviewed; Region: PRK00049
349521015953	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
349521015954	G1 box; other site
349521015955	GEF interaction site [polypeptide binding]; other site
349521015956	GTP/Mg2+ binding site [chemical binding]; other site
349521015957	Switch I region; other site
349521015958	G2 box; other site
349521015959	G3 box; other site
349521015960	Switch II region; other site
349521015961	G4 box; other site
349521015962	G5 box; other site
349521015963	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
349521015964	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
349521015965	Antibiotic Binding Site [chemical binding]; other site
349521015966	elongation factor G; Reviewed; Region: PRK00007
349521015967	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
349521015968	G1 box; other site
349521015969	putative GEF interaction site [polypeptide binding]; other site
349521015970	GTP/Mg2+ binding site [chemical binding]; other site
349521015971	Switch I region; other site
349521015972	G2 box; other site
349521015973	G3 box; other site
349521015974	Switch II region; other site
349521015975	G4 box; other site
349521015976	G5 box; other site
349521015977	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
349521015978	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
349521015979	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
349521015980	30S ribosomal protein S7; Validated; Region: PRK05302
349521015981	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
349521015982	S17 interaction site [polypeptide binding]; other site
349521015983	S8 interaction site; other site
349521015984	16S rRNA interaction site [nucleotide binding]; other site
349521015985	streptomycin interaction site [chemical binding]; other site
349521015986	23S rRNA interaction site [nucleotide binding]; other site
349521015987	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
349521015988	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
349521015989	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
349521015990	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
349521015991	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
349521015992	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
349521015993	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
349521015994	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
349521015995	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
349521015996	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
349521015997	DNA binding site [nucleotide binding]
349521015998	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
349521015999	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
349521016000	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
349521016001	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
349521016002	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
349521016003	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
349521016004	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
349521016005	RPB3 interaction site [polypeptide binding]; other site
349521016006	RPB1 interaction site [polypeptide binding]; other site
349521016007	RPB11 interaction site [polypeptide binding]; other site
349521016008	RPB10 interaction site [polypeptide binding]; other site
349521016009	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
349521016010	core dimer interface [polypeptide binding]; other site
349521016011	peripheral dimer interface [polypeptide binding]; other site
349521016012	L10 interface [polypeptide binding]; other site
349521016013	L11 interface [polypeptide binding]; other site
349521016014	putative EF-Tu interaction site [polypeptide binding]; other site
349521016015	putative EF-G interaction site [polypeptide binding]; other site
349521016016	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
349521016017	23S rRNA interface [nucleotide binding]; other site
349521016018	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
349521016019	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
349521016020	mRNA/rRNA interface [nucleotide binding]; other site
349521016021	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
349521016022	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
349521016023	23S rRNA interface [nucleotide binding]; other site
349521016024	L7/L12 interface [polypeptide binding]; other site
349521016025	putative thiostrepton binding site; other site
349521016026	L25 interface [polypeptide binding]; other site
349521016027	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
349521016028	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
349521016029	putative homodimer interface [polypeptide binding]; other site
349521016030	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
349521016031	heterodimer interface [polypeptide binding]; other site
349521016032	homodimer interface [polypeptide binding]; other site
349521016033	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
349521016034	elongation factor Tu; Reviewed; Region: PRK00049
349521016035	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
349521016036	G1 box; other site
349521016037	GEF interaction site [polypeptide binding]; other site
349521016038	GTP/Mg2+ binding site [chemical binding]; other site
349521016039	Switch I region; other site
349521016040	G2 box; other site
349521016041	G3 box; other site
349521016042	Switch II region; other site
349521016043	G4 box; other site
349521016044	G5 box; other site
349521016045	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
349521016046	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
349521016047	Antibiotic Binding Site [chemical binding]; other site
349521016048	Type III pantothenate kinase; Region: Pan_kinase; pfam03309
349521016049	HTH domain; Region: HTH_11; cl17392
349521016050	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
349521016051	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
349521016052	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
349521016053	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
349521016054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521016055	Walker A motif; other site
349521016056	ATP binding site [chemical binding]; other site
349521016057	Walker B motif; other site
349521016058	arginine finger; other site
349521016059	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521016060	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
349521016061	DNA binding residues [nucleotide binding]
349521016062	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349521016063	Integrase core domain; Region: rve; pfam00665
349521016064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349521016065	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
349521016066	generic binding surface I; other site
349521016067	generic binding surface II; other site
349521016068	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
349521016069	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
349521016070	active site
349521016071	HIGH motif; other site
349521016072	dimer interface [polypeptide binding]; other site
349521016073	KMSKS motif; other site
349521016074	putative peptidase; Provisional; Region: PRK11649
349521016075	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
349521016076	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521016077	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
349521016078	DsrE/DsrF-like family; Region: DrsE; pfam02635
349521016079	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
349521016080	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
349521016081	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
349521016082	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
349521016083	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
349521016084	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
349521016085	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
349521016086	Cl- selectivity filter; other site
349521016087	Cl- binding residues [ion binding]; other site
349521016088	pore gating glutamate residue; other site
349521016089	dimer interface [polypeptide binding]; other site
349521016090	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
349521016091	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
349521016092	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
349521016093	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349521016094	inhibitor-cofactor binding pocket; inhibition site
349521016095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521016096	catalytic residue [active]
349521016097	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
349521016098	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349521016099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521016100	TPR motif; other site
349521016101	binding surface
349521016102	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
349521016103	Transglycosylase; Region: Transgly; pfam00912
349521016104	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
349521016105	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
349521016106	Predicted kinase [General function prediction only]; Region: COG0645
349521016107	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
349521016108	ATP-binding site [chemical binding]; other site
349521016109	Gluconate-6-phosphate binding site [chemical binding]; other site
349521016110	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
349521016111	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
349521016112	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
349521016113	ligand binding site [chemical binding]; other site
349521016114	flexible hinge region; other site
349521016115	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349521016116	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521016117	ligand binding site [chemical binding]; other site
349521016118	flexible hinge region; other site
349521016119	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
349521016120	iron-sulfur cluster [ion binding]; other site
349521016121	[2Fe-2S] cluster binding site [ion binding]; other site
349521016122	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
349521016123	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
349521016124	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
349521016125	active site
349521016126	HIGH motif; other site
349521016127	nucleotide binding site [chemical binding]; other site
349521016128	active site
349521016129	KMSKS motif; other site
349521016130	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
349521016131	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
349521016132	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521016133	dimer interface [polypeptide binding]; other site
349521016134	phosphorylation site [posttranslational modification]
349521016135	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521016136	ATP binding site [chemical binding]; other site
349521016137	Mg2+ binding site [ion binding]; other site
349521016138	G-X-G motif; other site
349521016139	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349521016140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521016141	active site
349521016142	phosphorylation site [posttranslational modification]
349521016143	intermolecular recognition site; other site
349521016144	dimerization interface [polypeptide binding]; other site
349521016145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521016146	Walker A motif; other site
349521016147	ATP binding site [chemical binding]; other site
349521016148	Walker B motif; other site
349521016149	arginine finger; other site
349521016150	poly(A) polymerase; Region: pcnB; TIGR01942
349521016151	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
349521016152	active site
349521016153	NTP binding site [chemical binding]; other site
349521016154	metal binding triad [ion binding]; metal-binding site
349521016155	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
349521016156	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
349521016157	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
349521016158	catalytic center binding site [active]
349521016159	ATP binding site [chemical binding]; other site
349521016160	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
349521016161	active site
349521016162	oligomerization interface [polypeptide binding]; other site
349521016163	metal binding site [ion binding]; metal-binding site
349521016164	pantoate--beta-alanine ligase; Region: panC; TIGR00018
349521016165	Pantoate-beta-alanine ligase; Region: PanC; cd00560
349521016166	active site
349521016167	ATP-binding site [chemical binding]; other site
349521016168	pantoate-binding site; other site
349521016169	HXXH motif; other site
349521016170	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
349521016171	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
349521016172	active site
349521016173	dimer interface [polypeptide binding]; other site
349521016174	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
349521016175	dimer interface [polypeptide binding]; other site
349521016176	active site
349521016177	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
349521016178	catalytic center binding site [active]
349521016179	ATP binding site [chemical binding]; other site
349521016180	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
349521016181	homooctamer interface [polypeptide binding]; other site
349521016182	active site
349521016183	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
349521016184	UGMP family protein; Validated; Region: PRK09604
349521016185	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
349521016186	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
349521016187	Yqey-like protein; Region: YqeY; pfam09424
349521016188	DNA primase; Validated; Region: dnaG; PRK05667
349521016189	CHC2 zinc finger; Region: zf-CHC2; pfam01807
349521016190	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
349521016191	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
349521016192	active site
349521016193	metal binding site [ion binding]; metal-binding site
349521016194	interdomain interaction site; other site
349521016195	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
349521016196	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
349521016197	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
349521016198	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
349521016199	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
349521016200	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
349521016201	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349521016202	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
349521016203	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521016204	DNA binding residues [nucleotide binding]
349521016205	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
349521016206	active site
349521016207	NTP binding site [chemical binding]; other site
349521016208	metal binding triad [ion binding]; metal-binding site
349521016209	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521016210	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521016211	non-specific DNA binding site [nucleotide binding]; other site
349521016212	salt bridge; other site
349521016213	sequence-specific DNA binding site [nucleotide binding]; other site
349521016214	Domain of unknown function (DUF955); Region: DUF955; pfam06114
349521016215	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521016216	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521016217	non-specific DNA binding site [nucleotide binding]; other site
349521016218	salt bridge; other site
349521016219	sequence-specific DNA binding site [nucleotide binding]; other site
349521016220	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
349521016221	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521016222	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
349521016223	putative C-terminal domain interface [polypeptide binding]; other site
349521016224	putative GSH binding site (G-site) [chemical binding]; other site
349521016225	putative dimer interface [polypeptide binding]; other site
349521016226	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
349521016227	N-terminal domain interface [polypeptide binding]; other site
349521016228	dimer interface [polypeptide binding]; other site
349521016229	substrate binding pocket (H-site) [chemical binding]; other site
349521016230	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521016231	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521016232	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
349521016233	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
349521016234	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
349521016235	active site
349521016236	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
349521016237	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
349521016238	NAD(P) binding site [chemical binding]; other site
349521016239	catalytic residues [active]
349521016240	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
349521016241	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
349521016242	putative metal binding site [ion binding]; other site
349521016243	dimer interface [polypeptide binding]; other site
349521016244	BCCT family transporter; Region: BCCT; cl00569
349521016245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521016246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521016247	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
349521016248	putative effector binding pocket; other site
349521016249	putative dimerization interface [polypeptide binding]; other site
349521016250	short chain dehydrogenase; Provisional; Region: PRK12744
349521016251	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
349521016252	NADP binding site [chemical binding]; other site
349521016253	homodimer interface [polypeptide binding]; other site
349521016254	active site
349521016255	substrate binding site [chemical binding]; other site
349521016256	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
349521016257	MASE2 domain; Region: MASE2; pfam05230
349521016258	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
349521016259	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
349521016260	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521016261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521016262	dimer interface [polypeptide binding]; other site
349521016263	phosphorylation site [posttranslational modification]
349521016264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521016265	ATP binding site [chemical binding]; other site
349521016266	Mg2+ binding site [ion binding]; other site
349521016267	G-X-G motif; other site
349521016268	Response regulator receiver domain; Region: Response_reg; pfam00072
349521016269	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521016270	active site
349521016271	phosphorylation site [posttranslational modification]
349521016272	intermolecular recognition site; other site
349521016273	dimerization interface [polypeptide binding]; other site
349521016274	Response regulator receiver domain; Region: Response_reg; pfam00072
349521016275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521016276	active site
349521016277	phosphorylation site [posttranslational modification]
349521016278	intermolecular recognition site; other site
349521016279	dimerization interface [polypeptide binding]; other site
349521016280	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
349521016281	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349521016282	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521016283	dimer interface [polypeptide binding]; other site
349521016284	putative CheW interface [polypeptide binding]; other site
349521016285	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521016286	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
349521016287	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521016288	Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582
349521016289	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
349521016290	Methyltransferase domain; Region: Methyltransf_25; pfam13649
349521016291	S-adenosylmethionine binding site [chemical binding]; other site
349521016292	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
349521016293	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
349521016294	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
349521016295	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
349521016296	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
349521016297	putative deacylase active site [active]
349521016298	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
349521016299	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
349521016300	Y-family of DNA polymerases; Region: PolY; cl12025
349521016301	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
349521016302	generic binding surface II; other site
349521016303	ssDNA binding site; other site
349521016304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521016305	ATP binding site [chemical binding]; other site
349521016306	putative Mg++ binding site [ion binding]; other site
349521016307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521016308	nucleotide binding region [chemical binding]; other site
349521016309	ATP-binding site [chemical binding]; other site
349521016310	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521016311	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521016312	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
349521016313	dimerization interface [polypeptide binding]; other site
349521016314	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521016315	NAD(P) binding site [chemical binding]; other site
349521016316	active site
349521016317	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349521016318	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
349521016319	homotrimer interaction site [polypeptide binding]; other site
349521016320	putative active site [active]
349521016321	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
349521016322	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521016323	Zn2+ binding site [ion binding]; other site
349521016324	Mg2+ binding site [ion binding]; other site
349521016325	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
349521016326	synthetase active site [active]
349521016327	NTP binding site [chemical binding]; other site
349521016328	metal binding site [ion binding]; metal-binding site
349521016329	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
349521016330	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
349521016331	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
349521016332	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
349521016333	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
349521016334	catalytic site [active]
349521016335	G-X2-G-X-G-K; other site
349521016336	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521016337	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521016338	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349521016339	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
349521016340	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
349521016341	catalytic triad [active]
349521016342	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
349521016343	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
349521016344	putative active site [active]
349521016345	metal binding site [ion binding]; metal-binding site
349521016346	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
349521016347	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
349521016348	NAD(P) binding site [chemical binding]; other site
349521016349	catalytic residues [active]
349521016350	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
349521016351	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
349521016352	ethanolamine permease; Region: 2A0305; TIGR00908
349521016353	Predicted ATPase [General function prediction only]; Region: COG1485
349521016354	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
349521016355	GIY-YIG motif/motif A; other site
349521016356	putative active site [active]
349521016357	putative metal binding site [ion binding]; other site
349521016358	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
349521016359	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
349521016360	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349521016361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521016362	S-adenosylmethionine binding site [chemical binding]; other site
349521016363	Helix-turn-helix domain; Region: HTH_28; pfam13518
349521016364	Winged helix-turn helix; Region: HTH_29; pfam13551
349521016365	Homeodomain-like domain; Region: HTH_32; pfam13565
349521016366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521016367	Walker A motif; other site
349521016368	ATP binding site [chemical binding]; other site
349521016369	Walker B motif; other site
349521016370	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
349521016371	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
349521016372	DEAD-like helicases superfamily; Region: DEXDc; smart00487
349521016373	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521016374	ATP binding site [chemical binding]; other site
349521016375	putative Mg++ binding site [ion binding]; other site
349521016376	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
349521016377	nucleotide binding region [chemical binding]; other site
349521016378	ATP-binding site [chemical binding]; other site
349521016379	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
349521016380	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
349521016381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521016382	Walker A motif; other site
349521016383	ATP binding site [chemical binding]; other site
349521016384	Walker B motif; other site
349521016385	arginine finger; other site
349521016386	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521016387	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
349521016388	DNA binding residues [nucleotide binding]
349521016389	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349521016390	Integrase core domain; Region: rve; pfam00665
349521016391	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349521016392	hypothetical protein; Provisional; Region: PRK11820
349521016393	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
349521016394	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
349521016395	ribonuclease PH; Reviewed; Region: rph; PRK00173
349521016396	Ribonuclease PH; Region: RNase_PH_bact; cd11362
349521016397	hexamer interface [polypeptide binding]; other site
349521016398	active site
349521016399	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
349521016400	putative active site [active]
349521016401	putative catalytic site [active]
349521016402	putative DNA binding site [nucleotide binding]; other site
349521016403	putative phosphate binding site [ion binding]; other site
349521016404	metal binding site A [ion binding]; metal-binding site
349521016405	putative AP binding site [nucleotide binding]; other site
349521016406	putative metal binding site B [ion binding]; other site
349521016407	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349521016408	active site
349521016409	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349521016410	hypothetical protein; Provisional; Region: PRK10621
349521016411	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521016412	MgtC family; Region: MgtC; pfam02308
349521016413	Predicted membrane protein [Function unknown]; Region: COG3174
349521016414	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
349521016415	putative protease; Provisional; Region: PRK15452
349521016416	Peptidase family U32; Region: Peptidase_U32; pfam01136
349521016417	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349521016418	Interdomain contacts; other site
349521016419	Cytokine receptor motif; other site
349521016420	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
349521016421	Phosphotransferase enzyme family; Region: APH; pfam01636
349521016422	putative active site [active]
349521016423	putative substrate binding site [chemical binding]; other site
349521016424	ATP binding site [chemical binding]; other site
349521016425	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
349521016426	DNA polymerase I; Provisional; Region: PRK05755
349521016427	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
349521016428	active site
349521016429	metal binding site 1 [ion binding]; metal-binding site
349521016430	putative 5' ssDNA interaction site; other site
349521016431	metal binding site 3; metal-binding site
349521016432	metal binding site 2 [ion binding]; metal-binding site
349521016433	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
349521016434	putative DNA binding site [nucleotide binding]; other site
349521016435	putative metal binding site [ion binding]; other site
349521016436	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
349521016437	active site
349521016438	catalytic site [active]
349521016439	substrate binding site [chemical binding]; other site
349521016440	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
349521016441	active site
349521016442	DNA binding site [nucleotide binding]
349521016443	catalytic site [active]
349521016444	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
349521016445	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349521016446	Walker A motif; other site
349521016447	ATP binding site [chemical binding]; other site
349521016448	Walker B motif; other site
349521016449	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
349521016450	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
349521016451	Walker A motif; other site
349521016452	ATP binding site [chemical binding]; other site
349521016453	Walker B motif; other site
349521016454	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
349521016455	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349521016456	catalytic residue [active]
349521016457	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
349521016458	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
349521016459	YGGT family; Region: YGGT; pfam02325
349521016460	YGGT family; Region: YGGT; pfam02325
349521016461	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
349521016462	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
349521016463	Dynamin family; Region: Dynamin_N; pfam00350
349521016464	G1 box; other site
349521016465	GTP/Mg2+ binding site [chemical binding]; other site
349521016466	G2 box; other site
349521016467	Switch I region; other site
349521016468	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
349521016469	G3 box; other site
349521016470	Switch II region; other site
349521016471	GTP/Mg2+ binding site [chemical binding]; other site
349521016472	G4 box; other site
349521016473	G5 box; other site
349521016474	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
349521016475	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
349521016476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349521016477	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
349521016478	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
349521016479	active site
349521016480	dimerization interface [polypeptide binding]; other site
349521016481	HemN family oxidoreductase; Provisional; Region: PRK05660
349521016482	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349521016483	FeS/SAM binding site; other site
349521016484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521016485	S-adenosylmethionine binding site [chemical binding]; other site
349521016486	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
349521016487	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
349521016488	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
349521016489	HEAT repeats; Region: HEAT_2; pfam13646
349521016490	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521016491	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521016492	non-specific DNA binding site [nucleotide binding]; other site
349521016493	salt bridge; other site
349521016494	sequence-specific DNA binding site [nucleotide binding]; other site
349521016495	hypothetical protein; Reviewed; Region: PRK00024
349521016496	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
349521016497	MPN+ (JAMM) motif; other site
349521016498	Zinc-binding site [ion binding]; other site
349521016499	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
349521016500	putative active site [active]
349521016501	putative metal binding residues [ion binding]; other site
349521016502	signature motif; other site
349521016503	putative triphosphate binding site [ion binding]; other site
349521016504	dimer interface [polypeptide binding]; other site
349521016505	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
349521016506	S-adenosyl-L-homocysteine hydrolase, NAD binding domain; Region: AdoHcyase_NAD; smart00997
349521016507	NAD binding site [chemical binding]; other site
349521016508	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
349521016509	AAA-like domain; Region: AAA_10; pfam12846
349521016510	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
349521016511	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
349521016512	AAA-like domain; Region: AAA_10; pfam12846
349521016513	DDE superfamily endonuclease; Region: DDE_3; pfam13358
349521016514	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
349521016515	Homeodomain-like domain; Region: HTH_23; pfam13384
349521016516	Winged helix-turn helix; Region: HTH_29; pfam13551
349521016517	Homeodomain-like domain; Region: HTH_32; pfam13565
349521016518	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349521016519	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
349521016520	catalytic residues [active]
349521016521	Recombinase; Region: Recombinase; pfam07508
349521016522	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
349521016523	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
349521016524	dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232
349521016525	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521016526	Zn2+ binding site [ion binding]; other site
349521016527	Mg2+ binding site [ion binding]; other site
349521016528	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
349521016529	DNA protecting protein DprA; Region: dprA; TIGR00732
349521016530	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
349521016531	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
349521016532	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
349521016533	catalytic residues [active]
349521016534	catalytic nucleophile [active]
349521016535	Recombinase; Region: Recombinase; pfam07508
349521016536	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
349521016537	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
349521016538	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
349521016539	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521016540	Walker A motif; other site
349521016541	ATP binding site [chemical binding]; other site
349521016542	Walker B motif; other site
349521016543	Membrane fusogenic activity; Region: BMFP; pfam04380
349521016544	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
349521016545	Nitrogen regulatory protein P-II; Region: P-II; smart00938
349521016546	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
349521016547	Uncharacterized conserved protein [Function unknown]; Region: COG4095
349521016548	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349521016549	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
349521016550	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
349521016551	dimer interface [polypeptide binding]; other site
349521016552	active site
349521016553	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
349521016554	active site 1 [active]
349521016555	dimer interface [polypeptide binding]; other site
349521016556	active site 2 [active]
349521016557	spermidine synthase; Provisional; Region: PRK00811
349521016558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521016559	S-adenosylmethionine binding site [chemical binding]; other site
349521016560	arginine decarboxylase; Provisional; Region: PRK05354
349521016561	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
349521016562	dimer interface [polypeptide binding]; other site
349521016563	active site
349521016564	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349521016565	catalytic residues [active]
349521016566	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
349521016567	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
349521016568	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
349521016569	active site
349521016570	catalytic site [active]
349521016571	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
349521016572	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
349521016573	dimerization interface [polypeptide binding]; other site
349521016574	DPS ferroxidase diiron center [ion binding]; other site
349521016575	ion pore; other site
349521016576	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521016577	HAMP domain; Region: HAMP; pfam00672
349521016578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
349521016579	dimer interface [polypeptide binding]; other site
349521016580	phosphorylation site [posttranslational modification]
349521016581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521016582	ATP binding site [chemical binding]; other site
349521016583	Mg2+ binding site [ion binding]; other site
349521016584	G-X-G motif; other site
349521016585	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521016586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521016587	active site
349521016588	phosphorylation site [posttranslational modification]
349521016589	intermolecular recognition site; other site
349521016590	dimerization interface [polypeptide binding]; other site
349521016591	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521016592	DNA binding site [nucleotide binding]
349521016593	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
349521016594	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
349521016595	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521016596	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521016597	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521016598	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
349521016599	putative C-terminal domain interface [polypeptide binding]; other site
349521016600	putative GSH binding site (G-site) [chemical binding]; other site
349521016601	putative dimer interface [polypeptide binding]; other site
349521016602	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
349521016603	N-terminal domain interface [polypeptide binding]; other site
349521016604	dimer interface [polypeptide binding]; other site
349521016605	substrate binding pocket (H-site) [chemical binding]; other site
349521016606	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
349521016607	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
349521016608	C-terminal domain interface [polypeptide binding]; other site
349521016609	GSH binding site (G-site) [chemical binding]; other site
349521016610	dimer interface [polypeptide binding]; other site
349521016611	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
349521016612	N-terminal domain interface [polypeptide binding]; other site
349521016613	putative dimer interface [polypeptide binding]; other site
349521016614	active site
349521016615	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
349521016616	structural tetrad; other site
349521016617	FOG: WD40 repeat [General function prediction only]; Region: COG2319
349521016618	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353
349521016619	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
349521016620	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
349521016621	Ribosome modulation factor; Region: RMF; cl01207
349521016622	glutamate--cysteine ligase; Provisional; Region: PRK02107
349521016623	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
349521016624	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
349521016625	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
349521016626	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
349521016627	RNA binding site [nucleotide binding]; other site
349521016628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
349521016629	active site
349521016630	phosphorylation site [posttranslational modification]
349521016631	intermolecular recognition site; other site
349521016632	dimerization interface [polypeptide binding]; other site
349521016633	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521016634	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521016635	metal binding site [ion binding]; metal-binding site
349521016636	active site
349521016637	I-site; other site
349521016638	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521016639	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
349521016640	Part of AAA domain; Region: AAA_19; pfam13245
349521016641	Family description; Region: UvrD_C_2; pfam13538
349521016642	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521016643	Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379
349521016644	putative active site [active]
349521016645	putative metal binding site [ion binding]; other site
349521016646	Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379
349521016647	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521016648	putative DNA binding site [nucleotide binding]; other site
349521016649	putative Zn2+ binding site [ion binding]; other site
349521016650	5-oxoprolinase; Region: PLN02666
349521016651	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
349521016652	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
349521016653	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
349521016654	DctM-like transporters; Region: DctM; pfam06808
349521016655	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
349521016656	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
349521016657	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
349521016658	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
349521016659	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
349521016660	phosphomannomutase CpsG; Provisional; Region: PRK15414
349521016661	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
349521016662	active site
349521016663	substrate binding site [chemical binding]; other site
349521016664	metal binding site [ion binding]; metal-binding site
349521016665	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
349521016666	B3/4 domain; Region: B3_4; pfam03483
349521016667	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521016668	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521016669	substrate binding pocket [chemical binding]; other site
349521016670	membrane-bound complex binding site; other site
349521016671	hinge residues; other site
349521016672	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521016673	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349521016674	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521016675	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349521016676	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349521016677	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
349521016678	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
349521016679	AMP binding site [chemical binding]; other site
349521016680	metal binding site [ion binding]; metal-binding site
349521016681	active site
349521016682	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349521016683	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349521016684	Walker A/P-loop; other site
349521016685	ATP binding site [chemical binding]; other site
349521016686	Q-loop/lid; other site
349521016687	ABC transporter signature motif; other site
349521016688	Walker B; other site
349521016689	D-loop; other site
349521016690	H-loop/switch region; other site
349521016691	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
349521016692	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349521016693	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349521016694	active site
349521016695	catalytic tetrad [active]
349521016696	PIN domain; Region: PIN_3; pfam13470
349521016697	DNA binding domain, excisionase family; Region: excise; TIGR01764
349521016698	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
349521016699	Family description; Region: VCBS; pfam13517
349521016700	Family description; Region: VCBS; pfam13517
349521016701	Family description; Region: VCBS; pfam13517
349521016702	Family description; Region: VCBS; pfam13517
349521016703	Family description; Region: VCBS; pfam13517
349521016704	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
349521016705	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
349521016706	active site
349521016707	catalytic site [active]
349521016708	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349521016709	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349521016710	DNA binding site [nucleotide binding]
349521016711	domain linker motif; other site
349521016712	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
349521016713	dimerization interface [polypeptide binding]; other site
349521016714	ligand binding site [chemical binding]; other site
349521016715	Zinc-dependent metalloprotease; Region: ZnMc; smart00235
349521016716	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
349521016717	active site
349521016718	active site
349521016719	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
349521016720	putative FMN binding site [chemical binding]; other site
349521016721	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
349521016722	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521016723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521016724	homodimer interface [polypeptide binding]; other site
349521016725	catalytic residue [active]
349521016726	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
349521016727	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
349521016728	Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490
349521016729	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
349521016730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521016731	Walker A motif; other site
349521016732	ATP binding site [chemical binding]; other site
349521016733	Walker B motif; other site
349521016734	arginine finger; other site
349521016735	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
349521016736	metal ion-dependent adhesion site (MIDAS); other site
349521016737	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
349521016738	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
349521016739	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
349521016740	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
349521016741	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
349521016742	catalytic triad [active]
349521016743	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
349521016744	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
349521016745	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
349521016746	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
349521016747	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
349521016748	putative active site [active]
349521016749	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
349521016750	putative active site [active]
349521016751	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
349521016752	Precorrin-8X methylmutase; Region: CbiC; pfam02570
349521016753	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
349521016754	active site
349521016755	putative homodimer interface [polypeptide binding]; other site
349521016756	SAM binding site [chemical binding]; other site
349521016757	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
349521016758	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
349521016759	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
349521016760	homodimer interface [polypeptide binding]; other site
349521016761	active site
349521016762	SAM binding site [chemical binding]; other site
349521016763	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
349521016764	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
349521016765	cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027
349521016766	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
349521016767	active site
349521016768	SAM binding site [chemical binding]; other site
349521016769	homodimer interface [polypeptide binding]; other site
349521016770	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
349521016771	active site
349521016772	SAM binding site [chemical binding]; other site
349521016773	homodimer interface [polypeptide binding]; other site
349521016774	Cytochrome c; Region: Cytochrom_C; pfam00034
349521016775	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521016776	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349521016777	Coenzyme A binding pocket [chemical binding]; other site
349521016778	Helix-Turn-Helix DNA binding domain of putative Cfa-like transcription regulators; Region: HTH_Cfa-like_unk; cd04790
349521016779	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
349521016780	DNA binding residues [nucleotide binding]
349521016781	putative dimer interface [polypeptide binding]; other site
349521016782	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
349521016783	LysE type translocator; Region: LysE; cl00565
349521016784	Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; pfam09961
349521016785	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521016786	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
349521016787	C-terminal domain interface [polypeptide binding]; other site
349521016788	GSH binding site (G-site) [chemical binding]; other site
349521016789	dimer interface [polypeptide binding]; other site
349521016790	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
349521016791	N-terminal domain interface [polypeptide binding]; other site
349521016792	dimer interface [polypeptide binding]; other site
349521016793	substrate binding pocket (H-site) [chemical binding]; other site
349521016794	PA14 domain; Region: PA14; cl08459
349521016795	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
349521016796	DNA-binding site [nucleotide binding]; DNA binding site
349521016797	RNA-binding motif; other site
349521016798	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
349521016799	dimer interface [polypeptide binding]; other site
349521016800	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521016801	metal binding site [ion binding]; metal-binding site
349521016802	Predicted membrane protein [Function unknown]; Region: COG1238
349521016803	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
349521016804	exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178
349521016805	PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921
349521016806	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
349521016807	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
349521016808	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521016809	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521016810	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521016811	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
349521016812	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
349521016813	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
349521016814	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
349521016815	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
349521016816	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
349521016817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521016818	Coenzyme A binding pocket [chemical binding]; other site
349521016819	Uncharacterized conserved protein [Function unknown]; Region: COG1284
349521016820	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
349521016821	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
349521016822	putative deacylase active site [active]
349521016823	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521016824	Coenzyme A binding pocket [chemical binding]; other site
349521016825	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
349521016826	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
349521016827	putative NAD(P) binding site [chemical binding]; other site
349521016828	dimer interface [polypeptide binding]; other site
349521016829	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521016830	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521016831	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
349521016832	putative effector binding pocket; other site
349521016833	dimerization interface [polypeptide binding]; other site
349521016834	Surface antigen; Region: Bac_surface_Ag; pfam01103
349521016835	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
349521016836	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521016837	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521016838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521016839	TPR motif; other site
349521016840	binding surface
349521016841	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
349521016842	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
349521016843	conserved cys residue [active]
349521016844	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521016845	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
349521016846	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
349521016847	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
349521016848	active site
349521016849	catalytic triad [active]
349521016850	oxyanion hole [active]
349521016851	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
349521016852	Leucine rich repeat; Region: LRR_8; pfam13855
349521016853	Leucine rich repeat; Region: LRR_8; pfam13855
349521016854	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
349521016855	putative active site [active]
349521016856	putative metal binding residues [ion binding]; other site
349521016857	signature motif; other site
349521016858	putative dimer interface [polypeptide binding]; other site
349521016859	putative phosphate binding site [ion binding]; other site
349521016860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521016861	putative substrate translocation pore; other site
349521016862	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521016863	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
349521016864	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
349521016865	active site
349521016866	metal binding site [ion binding]; metal-binding site
349521016867	Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335
349521016868	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349521016869	catalytic core [active]
349521016870	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
349521016871	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
349521016872	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
349521016873	MPN+ (JAMM) motif; other site
349521016874	Zinc-binding site [ion binding]; other site
349521016875	AAA ATPase domain; Region: AAA_16; pfam13191
349521016876	Uncharacterized conserved protein [Function unknown]; Region: COG3791
349521016877	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
349521016878	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
349521016879	generic binding surface II; other site
349521016880	generic binding surface I; other site
349521016881	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
349521016882	putative active site [active]
349521016883	putative catalytic site [active]
349521016884	putative Mg binding site IVb [ion binding]; other site
349521016885	putative phosphate binding site [ion binding]; other site
349521016886	putative DNA binding site [nucleotide binding]; other site
349521016887	putative Mg binding site IVa [ion binding]; other site
349521016888	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
349521016889	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
349521016890	putative active site [active]
349521016891	Zn binding site [ion binding]; other site
349521016892	thioredoxin 2; Provisional; Region: PRK10996
349521016893	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
349521016894	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
349521016895	catalytic residues [active]
349521016896	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
349521016897	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
349521016898	active site flap/lid [active]
349521016899	nucleophilic elbow; other site
349521016900	catalytic triad [active]
349521016901	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
349521016902	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349521016903	substrate binding site [chemical binding]; other site
349521016904	ATP binding site [chemical binding]; other site
349521016905	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
349521016906	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349521016907	N-terminal plug; other site
349521016908	ligand-binding site [chemical binding]; other site
349521016909	isochorismate synthase DhbC; Validated; Region: PRK06923
349521016910	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
349521016911	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
349521016912	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
349521016913	acyl-activating enzyme (AAE) consensus motif; other site
349521016914	active site
349521016915	AMP binding site [chemical binding]; other site
349521016916	substrate binding site [chemical binding]; other site
349521016917	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
349521016918	hydrophobic substrate binding pocket; other site
349521016919	Isochorismatase family; Region: Isochorismatase; pfam00857
349521016920	active site
349521016921	conserved cis-peptide bond; other site
349521016922	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
349521016923	Condensation domain; Region: Condensation; pfam00668
349521016924	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
349521016925	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
349521016926	acyl-activating enzyme (AAE) consensus motif; other site
349521016927	AMP binding site [chemical binding]; other site
349521016928	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
349521016929	thioester reductase domain; Region: Thioester-redct; TIGR01746
349521016930	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
349521016931	putative NAD(P) binding site [chemical binding]; other site
349521016932	active site
349521016933	putative substrate binding site [chemical binding]; other site
349521016934	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
349521016935	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349521016936	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521016937	catalytic residue [active]
349521016938	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
349521016939	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349521016940	active site
349521016941	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
349521016942	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
349521016943	siderophore binding site; other site
349521016944	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
349521016945	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521016946	ABC-ATPase subunit  interface; other site
349521016947	dimer interface [polypeptide binding]; other site
349521016948	putative PBP binding regions; other site
349521016949	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521016950	ABC-ATPase subunit  interface; other site
349521016951	dimer interface [polypeptide binding]; other site
349521016952	putative PBP binding regions; other site
349521016953	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
349521016954	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
349521016955	Walker A/P-loop; other site
349521016956	ATP binding site [chemical binding]; other site
349521016957	Q-loop/lid; other site
349521016958	ABC transporter signature motif; other site
349521016959	Walker B; other site
349521016960	D-loop; other site
349521016961	H-loop/switch region; other site
349521016962	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
349521016963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349521016964	NAD(P) binding site [chemical binding]; other site
349521016965	active site
349521016966	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
349521016967	active site
349521016968	catalytic residues [active]
349521016969	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349521016970	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
349521016971	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
349521016972	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
349521016973	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
349521016974	catalytic residues [active]
349521016975	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
349521016976	dimerization interface [polypeptide binding]; other site
349521016977	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
349521016978	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
349521016979	Cl binding site [ion binding]; other site
349521016980	oligomer interface [polypeptide binding]; other site
349521016981	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
349521016982	PspA/IM30 family; Region: PspA_IM30; pfam04012
349521016983	yiaA/B two helix domain; Region: YiaAB; cl01759
349521016984	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521016985	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521016986	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521016987	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349521016988	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
349521016989	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
349521016990	phosphopeptide binding site; other site
349521016991	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521016992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521016993	S-adenosylmethionine binding site [chemical binding]; other site
349521016994	Cupin; Region: Cupin_6; pfam12852
349521016995	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
349521016996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521016997	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938
349521016998	PspA/IM30 family; Region: PspA_IM30; pfam04012
349521016999	Ion channel; Region: Ion_trans_2; pfam07885
349521017000	TrkA-N domain; Region: TrkA_N; pfam02254
349521017001	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
349521017002	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
349521017003	hypothetical protein; Provisional; Region: PRK11653
349521017004	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
349521017005	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
349521017006	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
349521017007	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
349521017008	DctM-like transporters; Region: DctM; pfam06808
349521017009	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
349521017010	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521017011	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521017012	substrate binding pocket [chemical binding]; other site
349521017013	membrane-bound complex binding site; other site
349521017014	hinge residues; other site
349521017015	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
349521017016	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
349521017017	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
349521017018	hypothetical protein; Provisional; Region: PRK05409
349521017019	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
349521017020	Thermostable hemolysin; Region: T_hemolysin; pfam12261
349521017021	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
349521017022	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
349521017023	acyl-activating enzyme (AAE) consensus motif; other site
349521017024	putative AMP binding site [chemical binding]; other site
349521017025	putative active site [active]
349521017026	putative CoA binding site [chemical binding]; other site
349521017027	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
349521017028	heme binding pocket [chemical binding]; other site
349521017029	heme ligand [chemical binding]; other site
349521017030	short chain dehydrogenase; Provisional; Region: PRK09072
349521017031	classical (c) SDRs; Region: SDR_c; cd05233
349521017032	NAD(P) binding site [chemical binding]; other site
349521017033	active site
349521017034	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349521017035	TPR motif; other site
349521017036	binding surface
349521017037	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521017038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521017039	active site
349521017040	phosphorylation site [posttranslational modification]
349521017041	intermolecular recognition site; other site
349521017042	dimerization interface [polypeptide binding]; other site
349521017043	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521017044	DNA binding site [nucleotide binding]
349521017045	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
349521017046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521017047	dimer interface [polypeptide binding]; other site
349521017048	phosphorylation site [posttranslational modification]
349521017049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521017050	ATP binding site [chemical binding]; other site
349521017051	Mg2+ binding site [ion binding]; other site
349521017052	G-X-G motif; other site
349521017053	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349521017054	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521017055	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521017056	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349521017057	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
349521017058	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349521017059	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349521017060	DNA binding residues [nucleotide binding]
349521017061	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
349521017062	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
349521017063	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
349521017064	Amidase; Region: Amidase; cl11426
349521017065	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349521017066	AMP-binding enzyme; Region: AMP-binding; pfam00501
349521017067	acyl-activating enzyme (AAE) consensus motif; other site
349521017068	AMP binding site [chemical binding]; other site
349521017069	active site
349521017070	CoA binding site [chemical binding]; other site
349521017071	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521017072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521017073	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349521017074	dimerization interface [polypeptide binding]; other site
349521017075	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349521017076	DNA binding residues [nucleotide binding]
349521017077	dimerization interface [polypeptide binding]; other site
349521017078	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
349521017079	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
349521017080	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349521017081	hypothetical protein; Provisional; Region: PRK05208
349521017082	PEP-CTERM motif; Region: VPEP; pfam07589
349521017083	putative glutathione S-transferase; Provisional; Region: PRK10357
349521017084	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349521017085	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
349521017086	dimer interface [polypeptide binding]; other site
349521017087	N-terminal domain interface [polypeptide binding]; other site
349521017088	putative substrate binding pocket (H-site) [chemical binding]; other site
349521017089	short chain dehydrogenase; Provisional; Region: PRK07035
349521017090	classical (c) SDRs; Region: SDR_c; cd05233
349521017091	NAD(P) binding site [chemical binding]; other site
349521017092	active site
349521017093	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
349521017094	catalytic core [active]
349521017095	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349521017096	Phosphotransferase enzyme family; Region: APH; pfam01636
349521017097	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
349521017098	putative active site [active]
349521017099	putative substrate binding site [chemical binding]; other site
349521017100	ATP binding site [chemical binding]; other site
349521017101	short chain dehydrogenase; Provisional; Region: PRK05650
349521017102	classical (c) SDRs; Region: SDR_c; cd05233
349521017103	NAD(P) binding site [chemical binding]; other site
349521017104	active site
349521017105	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
349521017106	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349521017107	active site
349521017108	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
349521017109	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521017110	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
349521017111	substrate binding pocket [chemical binding]; other site
349521017112	dimerization interface [polypeptide binding]; other site
349521017113	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
349521017114	active site
349521017115	catalytic site [active]
349521017116	substrate binding site [chemical binding]; other site
349521017117	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
349521017118	Ligand Binding Site [chemical binding]; other site
349521017119	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
349521017120	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
349521017121	Predicted permeases [General function prediction only]; Region: COG0679
349521017122	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
349521017123	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
349521017124	putative [Fe4-S4] binding site [ion binding]; other site
349521017125	putative molybdopterin cofactor binding site [chemical binding]; other site
349521017126	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
349521017127	putative molybdopterin cofactor binding site; other site
349521017128	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
349521017129	acyl-CoA esterase; Provisional; Region: PRK10673
349521017130	PGAP1-like protein; Region: PGAP1; pfam07819
349521017131	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
349521017132	active site
349521017133	homodimer interface [polypeptide binding]; other site
349521017134	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
349521017135	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
349521017136	additional DNA contacts [nucleotide binding]; other site
349521017137	mismatch recognition site; other site
349521017138	active site
349521017139	zinc binding site [ion binding]; other site
349521017140	DNA intercalation site [nucleotide binding]; other site
349521017141	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
349521017142	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
349521017143	cofactor binding site; other site
349521017144	DNA binding site [nucleotide binding]
349521017145	substrate interaction site [chemical binding]; other site
349521017146	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
349521017147	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
349521017148	ATP adenylyltransferase; Region: ATP_transf; pfam09830
349521017149	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
349521017150	Actin depolymerization factor/cofilin- and gelsolin-like domains; Region: ADF_gelsolin; cl15697
349521017151	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349521017152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521017153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349521017154	dimerization interface [polypeptide binding]; other site
349521017155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521017156	dimer interface [polypeptide binding]; other site
349521017157	phosphorylation site [posttranslational modification]
349521017158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521017159	ATP binding site [chemical binding]; other site
349521017160	Mg2+ binding site [ion binding]; other site
349521017161	G-X-G motif; other site
349521017162	YfhG lipoprotein; Region: Lipoprotein_20; cl08141
349521017163	response regulator GlrR; Provisional; Region: PRK15115
349521017164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521017165	active site
349521017166	phosphorylation site [posttranslational modification]
349521017167	intermolecular recognition site; other site
349521017168	dimerization interface [polypeptide binding]; other site
349521017169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521017170	Walker A motif; other site
349521017171	ATP binding site [chemical binding]; other site
349521017172	Walker B motif; other site
349521017173	arginine finger; other site
349521017174	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
349521017175	pseudo EF-hand loop; other site
349521017176	peptide binding pocket; other site
349521017177	Ca2+ binding site [ion binding]; other site
349521017178	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
349521017179	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
349521017180	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
349521017181	EamA-like transporter family; Region: EamA; pfam00892
349521017182	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
349521017183	MarR family; Region: MarR; pfam01047
349521017184	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521017185	substrate binding pocket [chemical binding]; other site
349521017186	membrane-bound complex binding site; other site
349521017187	hinge residues; other site
349521017188	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
349521017189	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521017190	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
349521017191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
349521017192	Uncharacterized conserved protein [Function unknown]; Region: COG1262
349521017193	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
349521017194	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
349521017195	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
349521017196	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
349521017197	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
349521017198	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
349521017199	dockerin binding interface; other site
349521017200	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349521017201	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349521017202	active site
349521017203	metal binding site [ion binding]; metal-binding site
349521017204	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
349521017205	DNA binding site [nucleotide binding]
349521017206	Protein of unknown function DUF45; Region: DUF45; cl00636
349521017207	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
349521017208	metal ion-dependent adhesion site (MIDAS); other site
349521017209	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
349521017210	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
349521017211	GIY-YIG motif/motif A; other site
349521017212	putative active site [active]
349521017213	putative metal binding site [ion binding]; other site
349521017214	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
349521017215	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
349521017216	HAMP domain; Region: HAMP; pfam00672
349521017217	dimerization interface [polypeptide binding]; other site
349521017218	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521017219	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521017220	metal binding site [ion binding]; metal-binding site
349521017221	active site
349521017222	I-site; other site
349521017223	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349521017224	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
349521017225	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
349521017226	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
349521017227	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
349521017228	active site
349521017229	metal binding site [ion binding]; metal-binding site
349521017230	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
349521017231	Na binding site [ion binding]; other site
349521017232	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
349521017233	Mechanosensitive ion channel; Region: MS_channel; pfam00924
349521017234	AAA domain; Region: AAA_22; pfam13401
349521017235	glutathione S-transferase; Provisional; Region: PRK15113
349521017236	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
349521017237	putative C-terminal domain interface [polypeptide binding]; other site
349521017238	putative GSH binding site (G-site) [chemical binding]; other site
349521017239	putative dimer interface [polypeptide binding]; other site
349521017240	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
349521017241	putative N-terminal domain interface [polypeptide binding]; other site
349521017242	putative dimer interface [polypeptide binding]; other site
349521017243	putative substrate binding pocket (H-site) [chemical binding]; other site
349521017244	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
349521017245	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349521017246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521017247	dimer interface [polypeptide binding]; other site
349521017248	phosphorylation site [posttranslational modification]
349521017249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521017250	ATP binding site [chemical binding]; other site
349521017251	Mg2+ binding site [ion binding]; other site
349521017252	G-X-G motif; other site
349521017253	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349521017254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521017255	active site
349521017256	phosphorylation site [posttranslational modification]
349521017257	intermolecular recognition site; other site
349521017258	dimerization interface [polypeptide binding]; other site
349521017259	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349521017260	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
349521017261	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
349521017262	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349521017263	catalytic residue [active]
349521017264	pyruvate carboxylase subunit B; Validated; Region: PRK09282
349521017265	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
349521017266	active site
349521017267	catalytic residues [active]
349521017268	metal binding site [ion binding]; metal-binding site
349521017269	homodimer binding site [polypeptide binding]; other site
349521017270	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349521017271	carboxyltransferase (CT) interaction site; other site
349521017272	biotinylation site [posttranslational modification]; other site
349521017273	pyruvate carboxylase subunit A; Validated; Region: PRK07178
349521017274	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349521017275	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
349521017276	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
349521017277	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
349521017278	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
349521017279	Walker A/P-loop; other site
349521017280	ATP binding site [chemical binding]; other site
349521017281	Q-loop/lid; other site
349521017282	ABC transporter signature motif; other site
349521017283	Walker B; other site
349521017284	D-loop; other site
349521017285	H-loop/switch region; other site
349521017286	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
349521017287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521017288	dimer interface [polypeptide binding]; other site
349521017289	conserved gate region; other site
349521017290	putative PBP binding loops; other site
349521017291	ABC-ATPase subunit interface; other site
349521017292	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
349521017293	NMT1-like family; Region: NMT1_2; pfam13379
349521017294	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_13; cd06324
349521017295	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349521017296	putative ligand binding site [chemical binding]; other site
349521017297	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
349521017298	Predicted ATPase [General function prediction only]; Region: COG5293
349521017299	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
349521017300	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
349521017301	catalytic nucleophile [active]
349521017302	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
349521017303	dimerization interface [polypeptide binding]; other site
349521017304	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349521017305	dimer interface [polypeptide binding]; other site
349521017306	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
349521017307	putative CheW interface [polypeptide binding]; other site
349521017308	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521017309	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; cl02380
349521017310	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
349521017311	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
349521017312	putative C-terminal domain interface [polypeptide binding]; other site
349521017313	putative GSH binding site (G-site) [chemical binding]; other site
349521017314	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
349521017315	putative dimer interface [polypeptide binding]; other site
349521017316	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
349521017317	dimer interface [polypeptide binding]; other site
349521017318	N-terminal domain interface [polypeptide binding]; other site
349521017319	putative substrate binding pocket (H-site) [chemical binding]; other site
349521017320	Predicted transcriptional regulator [Transcription]; Region: COG2378
349521017321	HTH domain; Region: HTH_11; pfam08279
349521017322	WYL domain; Region: WYL; pfam13280
349521017323	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
349521017324	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349521017325	putative active site [active]
349521017326	putative NTP binding site [chemical binding]; other site
349521017327	putative nucleic acid binding site [nucleotide binding]; other site
349521017328	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
349521017329	This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775
349521017330	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
349521017331	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
349521017332	conserved cys residue [active]
349521017333	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
349521017334	dimerization interface [polypeptide binding]; other site
349521017335	putative active cleft [active]
349521017336	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521017337	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
349521017338	active site
349521017339	metal binding site [ion binding]; metal-binding site
349521017340	Predicted transcriptional regulators [Transcription]; Region: COG1733
349521017341	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349521017342	dimerization interface [polypeptide binding]; other site
349521017343	putative DNA binding site [nucleotide binding]; other site
349521017344	putative Zn2+ binding site [ion binding]; other site
349521017345	Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787
349521017346	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
349521017347	DNA binding residues [nucleotide binding]
349521017348	dimer interface [polypeptide binding]; other site
349521017349	copper exporting ATPase; Provisional; Region: copA; PRK10671
349521017350	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
349521017351	metal-binding site [ion binding]
349521017352	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
349521017353	metal-binding site [ion binding]
349521017354	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349521017355	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349521017356	motif II; other site
349521017357	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
349521017358	Predicted metal-binding protein [General function prediction only]; Region: COG3019
349521017359	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
349521017360	putative metal binding site [ion binding]; other site
349521017361	Protein of unknown function, DUF393; Region: DUF393; pfam04134
349521017362	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
349521017363	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349521017364	putative active site [active]
349521017365	putative NTP binding site [chemical binding]; other site
349521017366	putative nucleic acid binding site [nucleotide binding]; other site
349521017367	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521017368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349521017369	Major Facilitator Superfamily; Region: MFS_1; pfam07690
349521017370	putative substrate translocation pore; other site
349521017371	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521017372	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521017373	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349521017374	dimerization interface [polypeptide binding]; other site
349521017375	integrase; Provisional; Region: int; PHA02601
349521017376	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349521017377	active site
349521017378	DNA binding site [nucleotide binding]
349521017379	Int/Topo IB signature motif; other site
349521017380	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349521017381	non-specific DNA binding site [nucleotide binding]; other site
349521017382	salt bridge; other site
349521017383	sequence-specific DNA binding site [nucleotide binding]; other site
349521017384	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
349521017385	active site
349521017386	metal binding site [ion binding]; metal-binding site
349521017387	interdomain interaction site; other site
349521017388	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
349521017389	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
349521017390	active site
349521017391	catalytic site [active]
349521017392	substrate binding site [chemical binding]; other site
349521017393	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
349521017394	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
349521017395	Phage-related protein [Function unknown]; Region: COG4695; cl01923
349521017396	Phage portal protein; Region: Phage_portal; pfam04860
349521017397	terminase ATPase subunit; Provisional; Region: P; PHA02535
349521017398	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
349521017399	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
349521017400	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
349521017401	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
349521017402	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
349521017403	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
349521017404	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
349521017405	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
349521017406	Protein of unknown function (DUF2586); Region: DUF2586; pfam10758
349521017407	Protein of unknown function (DUF2597); Region: DUF2597; pfam10772
349521017408	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
349521017409	Protein of unknown function (DUF2765); Region: DUF2765; pfam10963
349521017410	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
349521017411	Protein of unknown function (DUF2590); Region: DUF2590; pfam10761
349521017412	Baseplate J-like protein; Region: Baseplate_J; cl01294
349521017413	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
349521017414	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
349521017415	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
349521017416	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
349521017417	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
349521017418	Transglycosylase; Region: Transgly; cl17702
349521017419	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
349521017420	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
349521017421	Cellulose binding domain; Region: CBM_2; cl17741
349521017422	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
349521017423	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
349521017424	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
349521017425	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
349521017426	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
349521017427	SnoaL-like domain; Region: SnoaL_2; pfam12680
349521017428	putative transcriptional regulator; Provisional; Region: PRK11640
349521017429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521017430	TM2 domain; Region: TM2; pfam05154
349521017431	Pilin (bacterial filament); Region: Pilin; pfam00114
349521017432	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
349521017433	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
349521017434	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
349521017435	Helix-turn-helix domain; Region: HTH_18; pfam12833
349521017436	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
349521017437	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
349521017438	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
349521017439	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
349521017440	MarR family; Region: MarR; pfam01047
349521017441	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
349521017442	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
349521017443	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
349521017444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521017445	Coenzyme A binding pocket [chemical binding]; other site
349521017446	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521017447	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521017448	substrate binding pocket [chemical binding]; other site
349521017449	membrane-bound complex binding site; other site
349521017450	hinge residues; other site
349521017451	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
349521017452	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521017453	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
349521017454	dimerization interface [polypeptide binding]; other site
349521017455	substrate binding pocket [chemical binding]; other site
349521017456	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
349521017457	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349521017458	putative metal binding site [ion binding]; other site
349521017459	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
349521017460	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
349521017461	putative ligand binding site [chemical binding]; other site
349521017462	NAD binding site [chemical binding]; other site
349521017463	dimerization interface [polypeptide binding]; other site
349521017464	catalytic site [active]
349521017465	Predicted membrane protein [Function unknown]; Region: COG4763
349521017466	Acyltransferase family; Region: Acyl_transf_3; pfam01757
349521017467	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521017468	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521017469	substrate binding pocket [chemical binding]; other site
349521017470	membrane-bound complex binding site; other site
349521017471	hinge residues; other site
349521017472	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
349521017473	Prostaglandin dehydrogenases; Region: PGDH; cd05288
349521017474	NAD(P) binding site [chemical binding]; other site
349521017475	substrate binding site [chemical binding]; other site
349521017476	dimer interface [polypeptide binding]; other site
349521017477	short chain dehydrogenase; Provisional; Region: PRK06172
349521017478	classical (c) SDRs; Region: SDR_c; cd05233
349521017479	NAD(P) binding site [chemical binding]; other site
349521017480	active site
349521017481	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
349521017482	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349521017483	substrate binding site [chemical binding]; other site
349521017484	ATP binding site [chemical binding]; other site
349521017485	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
349521017486	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
349521017487	putative ligand binding site [chemical binding]; other site
349521017488	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
349521017489	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
349521017490	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
349521017491	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
349521017492	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
349521017493	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349521017494	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349521017495	DNA binding site [nucleotide binding]
349521017496	domain linker motif; other site
349521017497	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
349521017498	dimerization interface (closed form) [polypeptide binding]; other site
349521017499	ligand binding site [chemical binding]; other site
349521017500	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
349521017501	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
349521017502	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
349521017503	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
349521017504	Walker A/P-loop; other site
349521017505	ATP binding site [chemical binding]; other site
349521017506	Q-loop/lid; other site
349521017507	ABC transporter signature motif; other site
349521017508	Walker B; other site
349521017509	D-loop; other site
349521017510	H-loop/switch region; other site
349521017511	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
349521017512	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349521017513	ABC-ATPase subunit  interface; other site
349521017514	dimer interface [polypeptide binding]; other site
349521017515	putative PBP binding regions; other site
349521017516	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
349521017517	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
349521017518	intersubunit interface [polypeptide binding]; other site
349521017519	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
349521017520	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521017521	DNA-binding site [nucleotide binding]; DNA binding site
349521017522	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349521017523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521017524	homodimer interface [polypeptide binding]; other site
349521017525	catalytic residue [active]
349521017526	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
349521017527	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
349521017528	homodimer interface [polypeptide binding]; other site
349521017529	substrate-cofactor binding pocket; other site
349521017530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521017531	catalytic residue [active]
349521017532	VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358
349521017533	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
349521017534	RNB domain; Region: RNB; pfam00773
349521017535	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
349521017536	RNA binding site [nucleotide binding]; other site
349521017537	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
349521017538	Peptidase family M50; Region: Peptidase_M50; pfam02163
349521017539	active site
349521017540	putative substrate binding region [chemical binding]; other site
349521017541	Tetratricopeptide repeat; Region: TPR_12; pfam13424
349521017542	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
349521017543	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
349521017544	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
349521017545	heme binding site [chemical binding]; other site
349521017546	ferroxidase pore; other site
349521017547	ferroxidase diiron center [ion binding]; other site
349521017548	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
349521017549	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
349521017550	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
349521017551	PA14 domain; Region: PA14; cl08459
349521017552	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349521017553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521017554	Coenzyme A binding pocket [chemical binding]; other site
349521017555	universal stress protein UspE; Provisional; Region: PRK11175
349521017556	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349521017557	Ligand Binding Site [chemical binding]; other site
349521017558	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349521017559	Ligand Binding Site [chemical binding]; other site
349521017560	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
349521017561	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
349521017562	TrkA-N domain; Region: TrkA_N; pfam02254
349521017563	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
349521017564	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
349521017565	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349521017566	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
349521017567	Soluble P-type ATPase [General function prediction only]; Region: COG4087
349521017568	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
349521017569	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
349521017570	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349521017571	PYR/PP interface [polypeptide binding]; other site
349521017572	dimer interface [polypeptide binding]; other site
349521017573	TPP binding site [chemical binding]; other site
349521017574	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349521017575	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
349521017576	TPP-binding site [chemical binding]; other site
349521017577	dimer interface [polypeptide binding]; other site
349521017578	ACT domain; Region: ACT_5; pfam13710
349521017579	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
349521017580	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521017581	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521017582	active site
349521017583	ATP binding site [chemical binding]; other site
349521017584	substrate binding site [chemical binding]; other site
349521017585	activation loop (A-loop); other site
349521017586	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
349521017587	Catalytic domain of Protein Kinases; Region: PKc; cd00180
349521017588	active site
349521017589	ATP binding site [chemical binding]; other site
349521017590	substrate binding site [chemical binding]; other site
349521017591	activation loop (A-loop); other site
349521017592	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
349521017593	FHA domain; Region: FHA; pfam00498
349521017594	phosphopeptide binding site; other site
349521017595	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
349521017596	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
349521017597	phosphopeptide binding site; other site
349521017598	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
349521017599	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
349521017600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
349521017601	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
349521017602	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
349521017603	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
349521017604	aconitate hydratase; Validated; Region: PRK09277
349521017605	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
349521017606	substrate binding site [chemical binding]; other site
349521017607	ligand binding site [chemical binding]; other site
349521017608	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
349521017609	substrate binding site [chemical binding]; other site
349521017610	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
349521017611	Uncharacterized conserved protein [Function unknown]; Region: COG1739
349521017612	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
349521017613	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
349521017614	pteridine reductase; Provisional; Region: PRK09135
349521017615	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349521017616	S-adenosylmethionine binding site [chemical binding]; other site
349521017617	NAD-dependent deacetylase; Provisional; Region: PRK00481
349521017618	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
349521017619	NAD+ binding site [chemical binding]; other site
349521017620	substrate binding site [chemical binding]; other site
349521017621	Zn binding site [ion binding]; other site
349521017622	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
349521017623	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349521017624	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
349521017625	PEP-CTERM motif; Region: VPEP; pfam07589
349521017626	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
349521017627	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349521017628	Domain of unknown function (DUF1287); Region: DUF1287; pfam06940
349521017629	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
349521017630	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
349521017631	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
349521017632	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521017633	Walker A/P-loop; other site
349521017634	ATP binding site [chemical binding]; other site
349521017635	Q-loop/lid; other site
349521017636	ABC transporter signature motif; other site
349521017637	Walker B; other site
349521017638	D-loop; other site
349521017639	H-loop/switch region; other site
349521017640	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349521017641	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
349521017642	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349521017643	Walker A/P-loop; other site
349521017644	ATP binding site [chemical binding]; other site
349521017645	Q-loop/lid; other site
349521017646	ABC transporter signature motif; other site
349521017647	Walker B; other site
349521017648	D-loop; other site
349521017649	H-loop/switch region; other site
349521017650	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349521017651	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
349521017652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521017653	dimer interface [polypeptide binding]; other site
349521017654	conserved gate region; other site
349521017655	putative PBP binding loops; other site
349521017656	ABC-ATPase subunit interface; other site
349521017657	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
349521017658	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521017659	dimer interface [polypeptide binding]; other site
349521017660	conserved gate region; other site
349521017661	putative PBP binding loops; other site
349521017662	ABC-ATPase subunit interface; other site
349521017663	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
349521017664	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
349521017665	substrate binding site [chemical binding]; other site
349521017666	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349521017667	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349521017668	DNA binding site [nucleotide binding]
349521017669	domain linker motif; other site
349521017670	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
349521017671	dimerization interface [polypeptide binding]; other site
349521017672	ligand binding site [chemical binding]; other site
349521017673	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
349521017674	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349521017675	Walker A/P-loop; other site
349521017676	ATP binding site [chemical binding]; other site
349521017677	Q-loop/lid; other site
349521017678	ABC transporter signature motif; other site
349521017679	Walker B; other site
349521017680	D-loop; other site
349521017681	H-loop/switch region; other site
349521017682	TOBE domain; Region: TOBE_2; pfam08402
349521017683	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
349521017684	beta-galactosidase; Region: BGL; TIGR03356
349521017685	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349521017686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521017687	dimer interface [polypeptide binding]; other site
349521017688	conserved gate region; other site
349521017689	putative PBP binding loops; other site
349521017690	ABC-ATPase subunit interface; other site
349521017691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521017692	dimer interface [polypeptide binding]; other site
349521017693	conserved gate region; other site
349521017694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
349521017695	ABC-ATPase subunit interface; other site
349521017696	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521017697	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521017698	Transcriptional regulators [Transcription]; Region: PurR; COG1609
349521017699	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
349521017700	DNA binding site [nucleotide binding]
349521017701	domain linker motif; other site
349521017702	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_9; cd06290
349521017703	putative dimerization interface [polypeptide binding]; other site
349521017704	putative ligand binding site [chemical binding]; other site
349521017705	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
349521017706	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
349521017707	tetramer interface [polypeptide binding]; other site
349521017708	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521017709	catalytic residue [active]
349521017710	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
349521017711	cleavage site
349521017712	active site
349521017713	substrate binding sites [chemical binding]; other site
349521017714	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
349521017715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349521017716	active site
349521017717	phosphorylation site [posttranslational modification]
349521017718	intermolecular recognition site; other site
349521017719	dimerization interface [polypeptide binding]; other site
349521017720	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349521017721	DNA binding site [nucleotide binding]
349521017722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349521017723	dimer interface [polypeptide binding]; other site
349521017724	phosphorylation site [posttranslational modification]
349521017725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349521017726	ATP binding site [chemical binding]; other site
349521017727	Mg2+ binding site [ion binding]; other site
349521017728	G-X-G motif; other site
349521017729	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
349521017730	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
349521017731	active site
349521017732	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
349521017733	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
349521017734	Transglutaminase/protease-like homologues; Region: TGc; smart00460
349521017735	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349521017736	FOG: PKD repeat [General function prediction only]; Region: COG3291
349521017737	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
349521017738	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521017739	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
349521017740	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
349521017741	short chain dehydrogenase; Provisional; Region: PRK06180
349521017742	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
349521017743	NADP binding site [chemical binding]; other site
349521017744	active site
349521017745	steroid binding site; other site
349521017746	primosomal protein DnaI; Provisional; Region: PRK02854
349521017747	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
349521017748	dimer interface [polypeptide binding]; other site
349521017749	putative radical transfer pathway; other site
349521017750	diiron center [ion binding]; other site
349521017751	tyrosyl radical; other site
349521017752	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
349521017753	ATP cone domain; Region: ATP-cone; pfam03477
349521017754	ATP cone domain; Region: ATP-cone; pfam03477
349521017755	Class I ribonucleotide reductase; Region: RNR_I; cd01679
349521017756	active site
349521017757	dimer interface [polypeptide binding]; other site
349521017758	catalytic residues [active]
349521017759	effector binding site; other site
349521017760	R2 peptide binding site; other site
349521017761	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
349521017762	Pilin (bacterial filament); Region: Pilin; pfam00114
349521017763	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
349521017764	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
349521017765	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
349521017766	Pilin (bacterial filament); Region: Pilin; pfam00114
349521017767	Protein of unknown function (DUF419); Region: DUF419; pfam04237
349521017768	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
349521017769	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
349521017770	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521017771	Coenzyme A binding pocket [chemical binding]; other site
349521017772	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521017773	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521017774	substrate binding pocket [chemical binding]; other site
349521017775	membrane-bound complex binding site; other site
349521017776	hinge residues; other site
349521017777	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349521017778	active site 2 [active]
349521017779	active site 1 [active]
349521017780	PAS fold; Region: PAS_7; pfam12860
349521017781	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349521017782	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349521017783	metal binding site [ion binding]; metal-binding site
349521017784	active site
349521017785	I-site; other site
349521017786	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
349521017787	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
349521017788	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349521017789	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349521017790	HlyD family secretion protein; Region: HlyD_3; pfam13437
349521017791	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
349521017792	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521017793	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
349521017794	substrate binding pocket [chemical binding]; other site
349521017795	dimerization interface [polypeptide binding]; other site
349521017796	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
349521017797	putative acetyltransferase; Provisional; Region: PRK03624
349521017798	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349521017799	Coenzyme A binding pocket [chemical binding]; other site
349521017800	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
349521017801	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
349521017802	cleavage site
349521017803	active site
349521017804	substrate binding sites [chemical binding]; other site
349521017805	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521017806	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
349521017807	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
349521017808	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
349521017809	Peptidase family M23; Region: Peptidase_M23; pfam01551
349521017810	Putative esterase; Region: Esterase; pfam00756
349521017811	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
349521017812	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
349521017813	NADH(P)-binding; Region: NAD_binding_10; pfam13460
349521017814	putative NAD(P) binding site [chemical binding]; other site
349521017815	active site
349521017816	DoxX-like family; Region: DoxX_3; pfam13781
349521017817	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349521017818	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349521017819	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
349521017820	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
349521017821	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349521017822	catalytic residue [active]
349521017823	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
349521017824	substrate binding site [chemical binding]; other site
349521017825	active site
349521017826	catalytic residues [active]
349521017827	heterodimer interface [polypeptide binding]; other site
349521017828	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
349521017829	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
349521017830	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
349521017831	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
349521017832	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
349521017833	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
349521017834	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
349521017835	glycerol kinase; Provisional; Region: glpK; PRK00047
349521017836	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
349521017837	N- and C-terminal domain interface [polypeptide binding]; other site
349521017838	active site
349521017839	MgATP binding site [chemical binding]; other site
349521017840	catalytic site [active]
349521017841	metal binding site [ion binding]; metal-binding site
349521017842	glycerol binding site [chemical binding]; other site
349521017843	homotetramer interface [polypeptide binding]; other site
349521017844	homodimer interface [polypeptide binding]; other site
349521017845	FBP binding site [chemical binding]; other site
349521017846	protein IIAGlc interface [polypeptide binding]; other site
349521017847	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
349521017848	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349521017849	Walker A motif; other site
349521017850	ATP binding site [chemical binding]; other site
349521017851	Walker B motif; other site
349521017852	arginine finger; other site
349521017853	Transposase; Region: HTH_Tnp_1; cl17663
349521017854	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
349521017855	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
349521017856	Walker A/P-loop; other site
349521017857	ATP binding site [chemical binding]; other site
349521017858	Q-loop/lid; other site
349521017859	ABC transporter signature motif; other site
349521017860	Walker B; other site
349521017861	D-loop; other site
349521017862	H-loop/switch region; other site
349521017863	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
349521017864	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
349521017865	Walker A/P-loop; other site
349521017866	ATP binding site [chemical binding]; other site
349521017867	Q-loop/lid; other site
349521017868	ABC transporter signature motif; other site
349521017869	Walker B; other site
349521017870	D-loop; other site
349521017871	H-loop/switch region; other site
349521017872	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
349521017873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521017874	putative PBP binding loops; other site
349521017875	dimer interface [polypeptide binding]; other site
349521017876	ABC-ATPase subunit interface; other site
349521017877	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349521017878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521017879	dimer interface [polypeptide binding]; other site
349521017880	conserved gate region; other site
349521017881	putative PBP binding loops; other site
349521017882	ABC-ATPase subunit interface; other site
349521017883	Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294
349521017884	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521017885	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521017886	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521017887	substrate binding pocket [chemical binding]; other site
349521017888	membrane-bound complex binding site; other site
349521017889	hinge residues; other site
349521017890	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
349521017891	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
349521017892	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
349521017893	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
349521017894	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
349521017895	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349521017896	DNA-binding site [nucleotide binding]; DNA binding site
349521017897	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
349521017898	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
349521017899	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
349521017900	Walker A/P-loop; other site
349521017901	ATP binding site [chemical binding]; other site
349521017902	Q-loop/lid; other site
349521017903	ABC transporter signature motif; other site
349521017904	Walker B; other site
349521017905	D-loop; other site
349521017906	H-loop/switch region; other site
349521017907	TOBE domain; Region: TOBE_2; pfam08402
349521017908	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
349521017909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521017910	dimer interface [polypeptide binding]; other site
349521017911	conserved gate region; other site
349521017912	putative PBP binding loops; other site
349521017913	ABC-ATPase subunit interface; other site
349521017914	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
349521017915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349521017916	putative PBP binding loops; other site
349521017917	dimer interface [polypeptide binding]; other site
349521017918	ABC-ATPase subunit interface; other site
349521017919	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
349521017920	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
349521017921	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
349521017922	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
349521017923	active site
349521017924	trimer interface [polypeptide binding]; other site
349521017925	allosteric site; other site
349521017926	active site lid [active]
349521017927	hexamer (dimer of trimers) interface [polypeptide binding]; other site
349521017928	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
349521017929	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
349521017930	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
349521017931	active site
349521017932	dimer interface [polypeptide binding]; other site
349521017933	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
349521017934	glutaminase A; Region: Gln_ase; TIGR03814
349521017935	elongation factor G; Reviewed; Region: PRK12739
349521017936	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
349521017937	G1 box; other site
349521017938	putative GEF interaction site [polypeptide binding]; other site
349521017939	GTP/Mg2+ binding site [chemical binding]; other site
349521017940	Switch I region; other site
349521017941	G2 box; other site
349521017942	G3 box; other site
349521017943	Switch II region; other site
349521017944	G4 box; other site
349521017945	G5 box; other site
349521017946	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
349521017947	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
349521017948	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
349521017949	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
349521017950	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
349521017951	active site
349521017952	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
349521017953	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349521017954	active site
349521017955	nucleotide binding site [chemical binding]; other site
349521017956	HIGH motif; other site
349521017957	KMSKS motif; other site
349521017958	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
349521017959	nudix motif; other site
349521017960	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
349521017961	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349521017962	active site
349521017963	nucleotide binding site [chemical binding]; other site
349521017964	HIGH motif; other site
349521017965	KMSKS motif; other site
349521017966	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
349521017967	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
349521017968	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
349521017969	nudix motif; other site
349521017970	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
349521017971	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
349521017972	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
349521017973	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521017974	ATP binding site [chemical binding]; other site
349521017975	putative Mg++ binding site [ion binding]; other site
349521017976	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349521017977	nucleotide binding region [chemical binding]; other site
349521017978	ATP-binding site [chemical binding]; other site
349521017979	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
349521017980	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
349521017981	RNA ligase; Region: RNA_ligase; pfam09414
349521017982	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521017983	Zn2+ binding site [ion binding]; other site
349521017984	Mg2+ binding site [ion binding]; other site
349521017985	AAA domain; Region: AAA_33; pfam13671
349521017986	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349521017987	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
349521017988	arCOG04150 universal archaeal PUA-domain protein; Region: arCOG00985; TIGR03684
349521017989	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
349521017990	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349521017991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521017992	Walker A/P-loop; other site
349521017993	ATP binding site [chemical binding]; other site
349521017994	Q-loop/lid; other site
349521017995	ABC transporter signature motif; other site
349521017996	Walker B; other site
349521017997	D-loop; other site
349521017998	H-loop/switch region; other site
349521017999	RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306
349521018000	RNA ligase; Region: RNA_ligase; pfam09414
349521018001	proline dipeptidase; Provisional; Region: PRK13607
349521018002	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
349521018003	active site
349521018004	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
349521018005	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349521018006	Zn2+ binding site [ion binding]; other site
349521018007	Mg2+ binding site [ion binding]; other site
349521018008	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349521018009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349521018010	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349521018011	dimerization interface [polypeptide binding]; other site
349521018012	CAAX protease self-immunity; Region: Abi; pfam02517
349521018013	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
349521018014	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349521018015	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349521018016	ligand binding site [chemical binding]; other site
349521018017	flexible hinge region; other site
349521018018	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
349521018019	active site residue [active]
349521018020	CAAX protease self-immunity; Region: Abi; pfam02517
349521018021	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
349521018022	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
349521018023	MG2 domain; Region: A2M_N; pfam01835
349521018024	Alpha-2-macroglobulin family; Region: A2M; pfam00207
349521018025	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
349521018026	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
349521018027	Transglycosylase; Region: Transgly; pfam00912
349521018028	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
349521018029	Transposase [DNA replication, recombination, and repair]; Region: COG5433
349521018030	Nuclease-related domain; Region: NERD; pfam08378
349521018031	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
349521018032	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
349521018033	active site
349521018034	ATP binding site [chemical binding]; other site
349521018035	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
349521018036	DNA helicase, putative; Region: TIGR00376
349521018037	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349521018038	ATP binding site [chemical binding]; other site
349521018039	AAA domain; Region: AAA_30; pfam13604
349521018040	AAA domain; Region: AAA_12; pfam13087
349521018041	DNA sulfur modification protein DndB; Region: DNA_S_dndB; TIGR03233
349521018042	DGQHR domain; Region: DGQHR; TIGR03187
349521018043	hypothetical protein; Provisional; Region: PRK06850
349521018044	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
349521018045	Active Sites [active]
349521018046	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
349521018047	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521018048	Walker A/P-loop; other site
349521018049	ATP binding site [chemical binding]; other site
349521018050	Q-loop/lid; other site
349521018051	ABC transporter signature motif; other site
349521018052	Walker B; other site
349521018053	D-loop; other site
349521018054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349521018055	ABC transporter signature motif; other site
349521018056	Walker B; other site
349521018057	D-loop; other site
349521018058	H-loop/switch region; other site
349521018059	DNA sulfur modification protein DndE; Region: DNA_S_dndE; TIGR03184
349521018060	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
349521018061	AAA-like domain; Region: AAA_10; pfam12846
349521018062	DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236
349521018063	DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238
349521018064	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521018065	3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147
349521018066	conserved hypothetical protein; Region: TIGR02270
349521018067	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
349521018068	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
349521018069	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349521018070	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349521018071	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
349521018072	TniQ; Region: TniQ; pfam06527
349521018073	AAA domain; Region: AAA_22; pfam13401
349521018074	Integrase core domain; Region: rve; pfam00665
349521018075	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
349521018076	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
349521018077	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
349521018078	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
349521018079	glutaminase active site [active]
349521018080	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
349521018081	dimer interface [polypeptide binding]; other site
349521018082	active site
349521018083	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
349521018084	dimer interface [polypeptide binding]; other site
349521018085	active site
349521018086	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
349521018087	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
349521018088	Substrate binding site; other site
349521018089	Mg++ binding site; other site
349521018090	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
349521018091	active site
349521018092	substrate binding site [chemical binding]; other site
349521018093	CoA binding site [chemical binding]; other site
349521018094	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
349521018095	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
349521018096	gamma subunit interface [polypeptide binding]; other site
349521018097	epsilon subunit interface [polypeptide binding]; other site
349521018098	LBP interface [polypeptide binding]; other site
349521018099	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
349521018100	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349521018101	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
349521018102	alpha subunit interaction interface [polypeptide binding]; other site
349521018103	Walker A motif; other site
349521018104	ATP binding site [chemical binding]; other site
349521018105	Walker B motif; other site
349521018106	inhibitor binding site; inhibition site
349521018107	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
349521018108	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
349521018109	core domain interface [polypeptide binding]; other site
349521018110	delta subunit interface [polypeptide binding]; other site
349521018111	epsilon subunit interface [polypeptide binding]; other site
349521018112	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
349521018113	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349521018114	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
349521018115	beta subunit interaction interface [polypeptide binding]; other site
349521018116	Walker A motif; other site
349521018117	ATP binding site [chemical binding]; other site
349521018118	Walker B motif; other site
349521018119	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
349521018120	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
349521018121	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
349521018122	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
349521018123	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
349521018124	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
349521018125	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
349521018126	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
349521018127	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
349521018128	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
349521018129	ParB-like nuclease domain; Region: ParBc; pfam02195
349521018130	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349521018131	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349521018132	P-loop; other site
349521018133	Magnesium ion binding site [ion binding]; other site
349521018134	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
349521018135	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
349521018136	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
349521018137	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
349521018138	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
349521018139	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
349521018140	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349521018141	substrate binding pocket [chemical binding]; other site
349521018142	membrane-bound complex binding site; other site
349521018143	hinge residues; other site
349521018144	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
349521018145	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
349521018146	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
349521018147	trmE is a tRNA modification GTPase; Region: trmE; cd04164
349521018148	G1 box; other site
349521018149	GTP/Mg2+ binding site [chemical binding]; other site
349521018150	Switch I region; other site
349521018151	G2 box; other site
349521018152	Switch II region; other site
349521018153	G3 box; other site
349521018154	G4 box; other site
349521018155	G5 box; other site
349521018156	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
349521018157	membrane protein insertase; Provisional; Region: PRK01318
349521018158	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
349521018159	Ribonuclease P; Region: Ribonuclease_P; cl00457