-- dump date   	20140619_110231
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
656519000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
656519000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
656519000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519000004	Walker A motif; other site
656519000005	ATP binding site [chemical binding]; other site
656519000006	Walker B motif; other site
656519000007	arginine finger; other site
656519000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
656519000009	DnaA box-binding interface [nucleotide binding]; other site
656519000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
656519000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
656519000012	putative DNA binding surface [nucleotide binding]; other site
656519000013	dimer interface [polypeptide binding]; other site
656519000014	beta-clamp/clamp loader binding surface; other site
656519000015	beta-clamp/translesion DNA polymerase binding surface; other site
656519000016	S4 domain; Region: S4_2; pfam13275
656519000017	recombination protein F; Reviewed; Region: recF; PRK00064
656519000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
656519000019	Walker A/P-loop; other site
656519000020	ATP binding site [chemical binding]; other site
656519000021	Q-loop/lid; other site
656519000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519000023	ABC transporter signature motif; other site
656519000024	Walker B; other site
656519000025	D-loop; other site
656519000026	H-loop/switch region; other site
656519000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
656519000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519000029	ATP binding site [chemical binding]; other site
656519000030	Mg2+ binding site [ion binding]; other site
656519000031	G-X-G motif; other site
656519000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
656519000033	anchoring element; other site
656519000034	dimer interface [polypeptide binding]; other site
656519000035	ATP binding site [chemical binding]; other site
656519000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
656519000037	active site
656519000038	putative metal-binding site [ion binding]; other site
656519000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
656519000040	DNA gyrase subunit A; Validated; Region: PRK05560
656519000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
656519000042	CAP-like domain; other site
656519000043	active site
656519000044	primary dimer interface [polypeptide binding]; other site
656519000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519000051	glycerol kinase; Provisional; Region: glpK; PRK00047
656519000052	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
656519000053	N- and C-terminal domain interface [polypeptide binding]; other site
656519000054	active site
656519000055	MgATP binding site [chemical binding]; other site
656519000056	catalytic site [active]
656519000057	metal binding site [ion binding]; metal-binding site
656519000058	glycerol binding site [chemical binding]; other site
656519000059	homotetramer interface [polypeptide binding]; other site
656519000060	homodimer interface [polypeptide binding]; other site
656519000061	FBP binding site [chemical binding]; other site
656519000062	protein IIAGlc interface [polypeptide binding]; other site
656519000063	Predicted dehydrogenase [General function prediction only]; Region: COG0579
656519000064	hydroxyglutarate oxidase; Provisional; Region: PRK11728
656519000065	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
656519000066	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
656519000067	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
656519000068	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519000069	Protein of unknown function (DUF1667); Region: DUF1667; cl17602
656519000070	intracellular protease, PfpI family; Region: PfpI; TIGR01382
656519000071	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
656519000072	conserved cys residue [active]
656519000073	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
656519000074	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
656519000075	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
656519000076	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
656519000077	active site
656519000078	active pocket/dimerization site; other site
656519000079	phosphorylation site [posttranslational modification]
656519000080	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
656519000081	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519000082	DNA-binding site [nucleotide binding]; DNA binding site
656519000083	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
656519000084	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
656519000085	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
656519000086	putative substrate binding site [chemical binding]; other site
656519000087	putative ATP binding site [chemical binding]; other site
656519000088	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519000089	active site
656519000090	phosphorylation site [posttranslational modification]
656519000091	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
656519000092	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
656519000093	active site
656519000094	P-loop; other site
656519000095	phosphorylation site [posttranslational modification]
656519000096	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
656519000097	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
656519000098	SurA N-terminal domain; Region: SurA_N; pfam09312
656519000099	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
656519000100	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
656519000101	seryl-tRNA synthetase; Provisional; Region: PRK05431
656519000102	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
656519000103	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
656519000104	dimer interface [polypeptide binding]; other site
656519000105	active site
656519000106	motif 1; other site
656519000107	motif 2; other site
656519000108	motif 3; other site
656519000109	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
656519000110	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
656519000111	active site
656519000112	intersubunit interface [polypeptide binding]; other site
656519000113	catalytic residue [active]
656519000114	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
656519000115	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519000116	substrate binding site [chemical binding]; other site
656519000117	ATP binding site [chemical binding]; other site
656519000118	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519000119	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
656519000120	substrate binding site [chemical binding]; other site
656519000121	ATP binding site [chemical binding]; other site
656519000122	ATP cone domain; Region: ATP-cone; pfam03477
656519000123	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
656519000124	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
656519000125	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
656519000126	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161
656519000127	putative ligand binding site [chemical binding]; other site
656519000128	putative NAD binding site [chemical binding]; other site
656519000129	catalytic site [active]
656519000130	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
656519000131	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
656519000132	Int/Topo IB signature motif; other site
656519000133	Helix-turn-helix domain; Region: HTH_17; pfam12728
656519000134	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
656519000135	ParB-like nuclease domain; Region: ParB; smart00470
656519000136	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
656519000137	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
656519000138	active site
656519000139	DNA binding site [nucleotide binding]
656519000140	Int/Topo IB signature motif; other site
656519000141	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519000142	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
656519000143	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519000144	Walker A/P-loop; other site
656519000145	ATP binding site [chemical binding]; other site
656519000146	Q-loop/lid; other site
656519000147	ABC transporter signature motif; other site
656519000148	Walker B; other site
656519000149	D-loop; other site
656519000150	H-loop/switch region; other site
656519000151	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
656519000152	active site
656519000153	nucleotide binding site [chemical binding]; other site
656519000154	HIGH motif; other site
656519000155	KMSKS motif; other site
656519000156	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
656519000157	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
656519000158	tetramer interface [polypeptide binding]; other site
656519000159	active site
656519000160	Mg2+/Mn2+ binding site [ion binding]; other site
656519000161	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
656519000162	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
656519000163	PYR/PP interface [polypeptide binding]; other site
656519000164	dimer interface [polypeptide binding]; other site
656519000165	TPP binding site [chemical binding]; other site
656519000166	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
656519000167	TPP-binding site; other site
656519000168	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
656519000169	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
656519000170	active site
656519000171	Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182
656519000172	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519000173	putative active site [active]
656519000174	metal binding site [ion binding]; metal-binding site
656519000175	Transposase; Region: HTH_Tnp_1; pfam01527
656519000176	putative transposase OrfB; Reviewed; Region: PHA02517
656519000177	HTH-like domain; Region: HTH_21; pfam13276
656519000178	Integrase core domain; Region: rve; pfam00665
656519000179	Integrase core domain; Region: rve_3; pfam13683
656519000180	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519000181	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
656519000182	putative ADP-binding pocket [chemical binding]; other site
656519000183	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519000184	Transposase; Region: HTH_Tnp_1; pfam01527
656519000185	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
656519000186	HTH-like domain; Region: HTH_21; pfam13276
656519000187	Integrase core domain; Region: rve; pfam00665
656519000188	Integrase core domain; Region: rve_3; pfam13683
656519000189	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519000190	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519000191	Integrase core domain; Region: rve; pfam00665
656519000192	Transposase; Region: HTH_Tnp_1; pfam01527
656519000193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519000194	putative transposase OrfB; Reviewed; Region: PHA02517
656519000195	HTH-like domain; Region: HTH_21; pfam13276
656519000196	Integrase core domain; Region: rve; pfam00665
656519000197	Integrase core domain; Region: rve_3; pfam13683
656519000198	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519000199	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
656519000200	putative ADP-binding pocket [chemical binding]; other site
656519000201	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
656519000202	active site
656519000203	ATP binding site [chemical binding]; other site
656519000204	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
656519000205	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
656519000206	putative ADP-binding pocket [chemical binding]; other site
656519000207	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
656519000208	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
656519000209	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
656519000210	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
656519000211	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
656519000212	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
656519000213	putative NAD(P) binding site [chemical binding]; other site
656519000214	active site
656519000215	putative substrate binding site [chemical binding]; other site
656519000216	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519000217	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
656519000218	putative ADP-binding pocket [chemical binding]; other site
656519000219	Bacterial sugar transferase; Region: Bac_transf; pfam02397
656519000220	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
656519000221	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
656519000222	inhibitor-cofactor binding pocket; inhibition site
656519000223	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519000224	catalytic residue [active]
656519000225	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
656519000226	active site
656519000227	DNA binding site [nucleotide binding]
656519000228	Int/Topo IB signature motif; other site
656519000229	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
656519000230	non-specific DNA binding site [nucleotide binding]; other site
656519000231	salt bridge; other site
656519000232	sequence-specific DNA binding site [nucleotide binding]; other site
656519000233	DNA primase, catalytic core; Region: dnaG; TIGR01391
656519000234	DNA primase, catalytic core; Region: dnaG; TIGR01391
656519000235	CHC2 zinc finger; Region: zf-CHC2; cl17510
656519000236	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
656519000237	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
656519000238	active site
656519000239	metal binding site [ion binding]; metal-binding site
656519000240	interdomain interaction site; other site
656519000241	Uncharacterized conserved protein [Function unknown]; Region: COG3339
656519000242	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
656519000243	G2 box; other site
656519000244	Switch I region; other site
656519000245	G3 box; other site
656519000246	Switch II region; other site
656519000247	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
656519000248	RecT family; Region: RecT; pfam03837
656519000249	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
656519000250	MPN+ (JAMM) motif; other site
656519000251	Zinc-binding site [ion binding]; other site
656519000252	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519000253	MULE transposase domain; Region: MULE; pfam10551
656519000254	Transposase; Region: DDE_Tnp_ISL3; pfam01610
656519000255	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
656519000256	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519000257	FeS/SAM binding site; other site
656519000258	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
656519000259	SEC-C motif; Region: SEC-C; pfam02810
656519000260	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
656519000261	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
656519000262	Sulfate transporter family; Region: Sulfate_transp; pfam00916
656519000263	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
656519000264	Transposase domain (DUF772); Region: DUF772; pfam05598
656519000265	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
656519000266	Sulfatase; Region: Sulfatase; pfam00884
656519000267	putative transporter; Provisional; Region: PRK10484
656519000268	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
656519000269	Na binding site [ion binding]; other site
656519000270	MarR family; Region: MarR_2; pfam12802
656519000271	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
656519000272	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
656519000273	nucleotide binding site [chemical binding]; other site
656519000274	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
656519000275	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
656519000276	active site
656519000277	catalytic tetrad [active]
656519000278	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
656519000279	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
656519000280	Protein of unknown function (DUF328); Region: DUF328; pfam03883
656519000281	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
656519000282	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
656519000283	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
656519000284	putative active site [active]
656519000285	catalytic site [active]
656519000286	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
656519000287	putative active site [active]
656519000288	catalytic site [active]
656519000289	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519000290	MULE transposase domain; Region: MULE; pfam10551
656519000291	Transposase; Region: DDE_Tnp_ISL3; pfam01610
656519000292	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
656519000293	dimer interface [polypeptide binding]; other site
656519000294	putative CheW interface [polypeptide binding]; other site
656519000295	Transposase domain (DUF772); Region: DUF772; pfam05598
656519000296	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
656519000297	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
656519000298	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
656519000299	5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231
656519000300	ATP binding site [chemical binding]; other site
656519000301	active site
656519000302	substrate binding site [chemical binding]; other site
656519000303	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
656519000304	HSP70 interaction site [polypeptide binding]; other site
656519000305	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142
656519000306	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
656519000307	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
656519000308	catalytic motif [active]
656519000309	Zn binding site [ion binding]; other site
656519000310	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
656519000311	homodimer interaction site [polypeptide binding]; other site
656519000312	cofactor binding site; other site
656519000313	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
656519000314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
656519000315	Putative esterase; Region: Esterase; pfam00756
656519000316	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
656519000317	MarR family; Region: MarR_2; cl17246
656519000318	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
656519000319	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
656519000320	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
656519000321	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
656519000322	NAD binding site [chemical binding]; other site
656519000323	homodimer interface [polypeptide binding]; other site
656519000324	active site
656519000325	substrate binding site [chemical binding]; other site
656519000326	galactokinase; Provisional; Region: PRK05322
656519000327	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
656519000328	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
656519000329	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
656519000330	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
656519000331	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
656519000332	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
656519000333	Predicted transcriptional regulator [Transcription]; Region: COG4189
656519000334	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519000335	dimerization interface [polypeptide binding]; other site
656519000336	putative DNA binding site [nucleotide binding]; other site
656519000337	putative Zn2+ binding site [ion binding]; other site
656519000338	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519000339	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
656519000340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519000341	dimer interface [polypeptide binding]; other site
656519000342	conserved gate region; other site
656519000343	putative PBP binding loops; other site
656519000344	ABC-ATPase subunit interface; other site
656519000345	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
656519000346	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519000347	dimer interface [polypeptide binding]; other site
656519000348	conserved gate region; other site
656519000349	putative PBP binding loops; other site
656519000350	ABC-ATPase subunit interface; other site
656519000351	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
656519000352	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
656519000353	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
656519000354	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000355	PAS domain; Region: PAS_9; pfam13426
656519000356	putative active site [active]
656519000357	heme pocket [chemical binding]; other site
656519000358	PAS domain S-box; Region: sensory_box; TIGR00229
656519000359	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000360	putative active site [active]
656519000361	heme pocket [chemical binding]; other site
656519000362	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519000363	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000364	metal binding site [ion binding]; metal-binding site
656519000365	active site
656519000366	I-site; other site
656519000367	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000368	Zn2+ binding site [ion binding]; other site
656519000369	Mg2+ binding site [ion binding]; other site
656519000370	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
656519000371	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
656519000372	Fasciclin domain; Region: Fasciclin; pfam02469
656519000373	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
656519000374	active site
656519000375	intersubunit interactions; other site
656519000376	catalytic residue [active]
656519000377	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
656519000378	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
656519000379	homodimer interface [polypeptide binding]; other site
656519000380	substrate-cofactor binding pocket; other site
656519000381	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519000382	catalytic residue [active]
656519000383	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
656519000384	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
656519000385	chorismate binding enzyme; Region: Chorismate_bind; cl10555
656519000386	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
656519000387	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
656519000388	glutamine binding [chemical binding]; other site
656519000389	catalytic triad [active]
656519000390	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
656519000391	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
656519000392	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
656519000393	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
656519000394	HTH domain; Region: HTH_11; pfam08279
656519000395	Mga helix-turn-helix domain; Region: Mga; pfam05043
656519000396	PRD domain; Region: PRD; pfam00874
656519000397	PRD domain; Region: PRD; pfam00874
656519000398	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
656519000399	active site
656519000400	P-loop; other site
656519000401	phosphorylation site [posttranslational modification]
656519000402	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519000403	active site
656519000404	phosphorylation site [posttranslational modification]
656519000405	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519000406	active site
656519000407	phosphorylation site [posttranslational modification]
656519000408	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
656519000409	active site
656519000410	P-loop; other site
656519000411	phosphorylation site [posttranslational modification]
656519000412	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
656519000413	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
656519000414	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
656519000415	Nitrogen regulatory protein P-II; Region: P-II; smart00938
656519000416	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
656519000417	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519000418	putative DNA binding site [nucleotide binding]; other site
656519000419	putative Zn2+ binding site [ion binding]; other site
656519000420	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519000421	Walker A motif; other site
656519000422	ATP binding site [chemical binding]; other site
656519000423	Walker B motif; other site
656519000424	arginine finger; other site
656519000425	Transcriptional antiterminator [Transcription]; Region: COG3933
656519000426	PRD domain; Region: PRD; pfam00874
656519000427	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
656519000428	active pocket/dimerization site; other site
656519000429	active site
656519000430	phosphorylation site [posttranslational modification]
656519000431	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519000432	dimerization domain swap beta strand [polypeptide binding]; other site
656519000433	regulatory protein interface [polypeptide binding]; other site
656519000434	active site
656519000435	regulatory phosphorylation site [posttranslational modification]; other site
656519000436	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
656519000437	active site
656519000438	P-loop; other site
656519000439	phosphorylation site [posttranslational modification]
656519000440	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
656519000441	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
656519000442	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
656519000443	methionine cluster; other site
656519000444	active site
656519000445	phosphorylation site [posttranslational modification]
656519000446	metal binding site [ion binding]; metal-binding site
656519000447	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
656519000448	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
656519000449	NAD binding site [chemical binding]; other site
656519000450	sugar binding site [chemical binding]; other site
656519000451	divalent metal binding site [ion binding]; other site
656519000452	tetramer (dimer of dimers) interface [polypeptide binding]; other site
656519000453	dimer interface [polypeptide binding]; other site
656519000454	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
656519000455	beta-galactosidase; Region: BGL; TIGR03356
656519000456	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
656519000457	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
656519000458	active site
656519000459	motif I; other site
656519000460	motif II; other site
656519000461	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
656519000462	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
656519000463	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
656519000464	ligand binding site [chemical binding]; other site
656519000465	CAT RNA binding domain; Region: CAT_RBD; smart01061
656519000466	transcriptional antiterminator BglG; Provisional; Region: PRK09772
656519000467	PRD domain; Region: PRD; pfam00874
656519000468	PRD domain; Region: PRD; pfam00874
656519000469	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
656519000470	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
656519000471	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
656519000472	active site turn [active]
656519000473	phosphorylation site [posttranslational modification]
656519000474	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
656519000475	HPr interaction site; other site
656519000476	glycerol kinase (GK) interaction site [polypeptide binding]; other site
656519000477	active site
656519000478	phosphorylation site [posttranslational modification]
656519000479	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
656519000480	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
656519000481	active site
656519000482	trimer interface [polypeptide binding]; other site
656519000483	allosteric site; other site
656519000484	active site lid [active]
656519000485	hexamer (dimer of trimers) interface [polypeptide binding]; other site
656519000486	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
656519000487	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
656519000488	active site
656519000489	dimer interface [polypeptide binding]; other site
656519000490	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
656519000491	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
656519000492	active site
656519000493	FMN binding site [chemical binding]; other site
656519000494	substrate binding site [chemical binding]; other site
656519000495	putative catalytic residue [active]
656519000496	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
656519000497	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
656519000498	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
656519000499	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519000500	Integrase core domain; Region: rve; pfam00665
656519000501	DDE domain; Region: DDE_Tnp_IS240; pfam13610
656519000502	Integrase core domain; Region: rve_3; cl15866
656519000503	Cupin domain; Region: Cupin_2; pfam07883
656519000504	Predicted permeases [General function prediction only]; Region: COG0679
656519000505	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519000506	dimerization domain swap beta strand [polypeptide binding]; other site
656519000507	regulatory protein interface [polypeptide binding]; other site
656519000508	active site
656519000509	regulatory phosphorylation site [posttranslational modification]; other site
656519000510	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519000511	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519000512	DNA-binding site [nucleotide binding]; DNA binding site
656519000513	FCD domain; Region: FCD; pfam07729
656519000514	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519000515	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519000516	DNA-binding site [nucleotide binding]; DNA binding site
656519000517	FCD domain; Region: FCD; pfam07729
656519000518	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
656519000519	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519000520	Walker A/P-loop; other site
656519000521	ATP binding site [chemical binding]; other site
656519000522	Q-loop/lid; other site
656519000523	ABC transporter signature motif; other site
656519000524	Walker B; other site
656519000525	D-loop; other site
656519000526	H-loop/switch region; other site
656519000527	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
656519000528	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
656519000529	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
656519000530	TM-ABC transporter signature motif; other site
656519000531	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
656519000532	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
656519000533	ligand binding site [chemical binding]; other site
656519000534	dimerization interface [polypeptide binding]; other site
656519000535	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
656519000536	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
656519000537	tetramer interface [polypeptide binding]; other site
656519000538	TPP-binding site [chemical binding]; other site
656519000539	heterodimer interface [polypeptide binding]; other site
656519000540	phosphorylation loop region [posttranslational modification]
656519000541	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
656519000542	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
656519000543	alpha subunit interface [polypeptide binding]; other site
656519000544	TPP binding site [chemical binding]; other site
656519000545	heterodimer interface [polypeptide binding]; other site
656519000546	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519000547	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
656519000548	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
656519000549	E3 interaction surface; other site
656519000550	lipoyl attachment site [posttranslational modification]; other site
656519000551	e3 binding domain; Region: E3_binding; pfam02817
656519000552	e3 binding domain; Region: E3_binding; pfam02817
656519000553	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
656519000554	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
656519000555	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
656519000556	TM-ABC transporter signature motif; other site
656519000557	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
656519000558	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
656519000559	TM-ABC transporter signature motif; other site
656519000560	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317
656519000561	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
656519000562	putative ligand binding site [chemical binding]; other site
656519000563	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
656519000564	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
656519000565	Walker A/P-loop; other site
656519000566	ATP binding site [chemical binding]; other site
656519000567	Q-loop/lid; other site
656519000568	ABC transporter signature motif; other site
656519000569	Walker B; other site
656519000570	D-loop; other site
656519000571	H-loop/switch region; other site
656519000572	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
656519000573	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
656519000574	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
656519000575	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
656519000576	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
656519000577	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
656519000578	Metal-binding active site; metal-binding site
656519000579	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
656519000580	classical (c) SDRs; Region: SDR_c; cd05233
656519000581	NAD(P) binding site [chemical binding]; other site
656519000582	active site
656519000583	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
656519000584	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
656519000585	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
656519000586	active site
656519000587	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
656519000588	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
656519000589	putative catalytic cysteine [active]
656519000590	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
656519000591	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
656519000592	CoA-ligase; Region: Ligase_CoA; pfam00549
656519000593	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
656519000594	CoA binding domain; Region: CoA_binding; pfam02629
656519000595	CoA-ligase; Region: Ligase_CoA; pfam00549
656519000596	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
656519000597	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519000598	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519000599	Malic enzyme, N-terminal domain; Region: malic; pfam00390
656519000600	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
656519000601	putative NAD(P) binding site [chemical binding]; other site
656519000602	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
656519000603	Malic enzyme, N-terminal domain; Region: malic; pfam00390
656519000604	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
656519000605	putative NAD(P) binding site [chemical binding]; other site
656519000606	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
656519000607	pyruvate phosphate dikinase; Provisional; Region: PRK09279
656519000608	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
656519000609	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
656519000610	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
656519000611	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
656519000612	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
656519000613	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
656519000614	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
656519000615	Ligand Binding Site [chemical binding]; other site
656519000616	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
656519000617	dimer interface [polypeptide binding]; other site
656519000618	substrate binding site [chemical binding]; other site
656519000619	metal binding sites [ion binding]; metal-binding site
656519000620	Protein of unknown function (DUF964); Region: DUF964; pfam06133
656519000621	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000622	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
656519000623	putative active site [active]
656519000624	heme pocket [chemical binding]; other site
656519000625	PAS domain; Region: PAS; smart00091
656519000626	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
656519000627	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000628	putative active site [active]
656519000629	heme pocket [chemical binding]; other site
656519000630	PAS domain S-box; Region: sensory_box; TIGR00229
656519000631	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000632	putative active site [active]
656519000633	heme pocket [chemical binding]; other site
656519000634	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519000635	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000636	metal binding site [ion binding]; metal-binding site
656519000637	active site
656519000638	I-site; other site
656519000639	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000640	Zn2+ binding site [ion binding]; other site
656519000641	Mg2+ binding site [ion binding]; other site
656519000642	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519000643	dimerization domain swap beta strand [polypeptide binding]; other site
656519000644	regulatory protein interface [polypeptide binding]; other site
656519000645	active site
656519000646	regulatory phosphorylation site [posttranslational modification]; other site
656519000647	GAF domain; Region: GAF; pfam01590
656519000648	PAS fold; Region: PAS; pfam00989
656519000649	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000650	putative active site [active]
656519000651	heme pocket [chemical binding]; other site
656519000652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000653	PAS domain; Region: PAS_9; pfam13426
656519000654	putative active site [active]
656519000655	heme pocket [chemical binding]; other site
656519000656	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519000657	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000658	metal binding site [ion binding]; metal-binding site
656519000659	active site
656519000660	I-site; other site
656519000661	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000662	Zn2+ binding site [ion binding]; other site
656519000663	Mg2+ binding site [ion binding]; other site
656519000664	Late competence development protein ComFB; Region: ComFB; pfam10719
656519000665	PAS domain; Region: PAS_9; pfam13426
656519000666	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000667	PAS fold; Region: PAS_3; pfam08447
656519000668	putative active site [active]
656519000669	heme pocket [chemical binding]; other site
656519000670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000671	PAS fold; Region: PAS_3; pfam08447
656519000672	putative active site [active]
656519000673	heme pocket [chemical binding]; other site
656519000674	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519000675	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000676	metal binding site [ion binding]; metal-binding site
656519000677	active site
656519000678	I-site; other site
656519000679	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519000680	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000681	Zn2+ binding site [ion binding]; other site
656519000682	Mg2+ binding site [ion binding]; other site
656519000683	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
656519000684	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519000685	dimerization interface [polypeptide binding]; other site
656519000686	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
656519000687	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
656519000688	dimer interface [polypeptide binding]; other site
656519000689	putative CheW interface [polypeptide binding]; other site
656519000690	PAS domain S-box; Region: sensory_box; TIGR00229
656519000691	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000692	PAS fold; Region: PAS_3; pfam08447
656519000693	putative active site [active]
656519000694	heme pocket [chemical binding]; other site
656519000695	PAS domain S-box; Region: sensory_box; TIGR00229
656519000696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000697	putative active site [active]
656519000698	heme pocket [chemical binding]; other site
656519000699	PAS domain S-box; Region: sensory_box; TIGR00229
656519000700	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000701	putative active site [active]
656519000702	heme pocket [chemical binding]; other site
656519000703	PAS domain; Region: PAS_9; pfam13426
656519000704	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000705	putative active site [active]
656519000706	heme pocket [chemical binding]; other site
656519000707	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
656519000708	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519000709	dimer interface [polypeptide binding]; other site
656519000710	phosphorylation site [posttranslational modification]
656519000711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519000712	ATP binding site [chemical binding]; other site
656519000713	Mg2+ binding site [ion binding]; other site
656519000714	G-X-G motif; other site
656519000715	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
656519000716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519000717	active site
656519000718	phosphorylation site [posttranslational modification]
656519000719	intermolecular recognition site; other site
656519000720	dimerization interface [polypeptide binding]; other site
656519000721	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
656519000722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519000723	S-adenosylmethionine binding site [chemical binding]; other site
656519000724	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
656519000725	B12 binding site [chemical binding]; other site
656519000726	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519000727	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000728	metal binding site [ion binding]; metal-binding site
656519000729	active site
656519000730	I-site; other site
656519000731	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
656519000732	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519000733	ATP-grasp domain; Region: ATP-grasp_4; cl17255
656519000734	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
656519000735	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519000736	ATP-grasp domain; Region: ATP-grasp_4; cl17255
656519000737	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
656519000738	IMP binding site; other site
656519000739	dimer interface [polypeptide binding]; other site
656519000740	interdomain contacts; other site
656519000741	partial ornithine binding site; other site
656519000742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000743	putative active site [active]
656519000744	heme pocket [chemical binding]; other site
656519000745	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000746	putative active site [active]
656519000747	heme pocket [chemical binding]; other site
656519000748	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000749	putative active site [active]
656519000750	PAS fold; Region: PAS_3; pfam08447
656519000751	heme pocket [chemical binding]; other site
656519000752	PAS domain S-box; Region: sensory_box; TIGR00229
656519000753	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000754	putative active site [active]
656519000755	heme pocket [chemical binding]; other site
656519000756	GAF domain; Region: GAF_3; pfam13492
656519000757	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519000758	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000759	metal binding site [ion binding]; metal-binding site
656519000760	active site
656519000761	I-site; other site
656519000762	PAS domain S-box; Region: sensory_box; TIGR00229
656519000763	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000764	putative active site [active]
656519000765	heme pocket [chemical binding]; other site
656519000766	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519000767	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000768	metal binding site [ion binding]; metal-binding site
656519000769	active site
656519000770	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519000771	I-site; other site
656519000772	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000773	Zn2+ binding site [ion binding]; other site
656519000774	Mg2+ binding site [ion binding]; other site
656519000775	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
656519000776	metal binding site [ion binding]; metal-binding site
656519000777	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
656519000778	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
656519000779	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
656519000780	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352
656519000781	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
656519000782	active site
656519000783	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
656519000784	domain_subunit interface; other site
656519000785	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
656519000786	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
656519000787	active site
656519000788	FMN binding site [chemical binding]; other site
656519000789	substrate binding site [chemical binding]; other site
656519000790	3Fe-4S cluster binding site [ion binding]; other site
656519000791	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
656519000792	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
656519000793	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
656519000794	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
656519000795	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
656519000796	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
656519000797	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
656519000798	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
656519000799	homotrimer interaction site [polypeptide binding]; other site
656519000800	putative active site [active]
656519000801	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
656519000802	PLD-like domain; Region: PLDc_2; pfam13091
656519000803	putative active site [active]
656519000804	catalytic site [active]
656519000805	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
656519000806	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
656519000807	ATP binding site [chemical binding]; other site
656519000808	putative Mg++ binding site [ion binding]; other site
656519000809	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519000810	nucleotide binding region [chemical binding]; other site
656519000811	ATP-binding site [chemical binding]; other site
656519000812	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
656519000813	nucleotide binding site/active site [active]
656519000814	HIT family signature motif; other site
656519000815	catalytic residue [active]
656519000816	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
656519000817	DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238
656519000818	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519000819	Transposase; Region: HTH_Tnp_1; pfam01527
656519000820	Transposase; Region: HTH_Tnp_1; pfam01527
656519000821	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
656519000822	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
656519000823	HTH-like domain; Region: HTH_21; pfam13276
656519000824	Integrase core domain; Region: rve; pfam00665
656519000825	Integrase core domain; Region: rve_3; pfam13683
656519000826	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
656519000827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519000828	AAA-like domain; Region: AAA_10; pfam12846
656519000829	Walker A motif; other site
656519000830	ATP binding site [chemical binding]; other site
656519000831	Walker B motif; other site
656519000832	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
656519000833	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
656519000834	minor groove reading motif; other site
656519000835	helix-hairpin-helix signature motif; other site
656519000836	substrate binding pocket [chemical binding]; other site
656519000837	active site
656519000838	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
656519000839	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
656519000840	putative active site [active]
656519000841	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
656519000842	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
656519000843	cofactor binding site; other site
656519000844	DNA binding site [nucleotide binding]
656519000845	substrate interaction site [chemical binding]; other site
656519000846	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
656519000847	Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417
656519000848	YvrJ protein family; Region: YvrJ; pfam12841
656519000849	transposase; Provisional; Region: PRK06526
656519000850	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519000851	Walker A motif; other site
656519000852	ATP binding site [chemical binding]; other site
656519000853	Walker B motif; other site
656519000854	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519000855	Transposase; Region: HTH_Tnp_1; pfam01527
656519000856	HTH-like domain; Region: HTH_21; pfam13276
656519000857	Integrase core domain; Region: rve; pfam00665
656519000858	Integrase core domain; Region: rve_3; pfam13683
656519000859	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
656519000860	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
656519000861	SEC-C motif; Region: SEC-C; pfam02810
656519000862	GAF domain; Region: GAF; pfam01590
656519000863	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000864	PAS domain; Region: PAS_9; pfam13426
656519000865	putative active site [active]
656519000866	heme pocket [chemical binding]; other site
656519000867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519000868	PAS fold; Region: PAS_3; pfam08447
656519000869	putative active site [active]
656519000870	heme pocket [chemical binding]; other site
656519000871	GAF domain; Region: GAF_3; pfam13492
656519000872	GAF domain; Region: GAF_2; pfam13185
656519000873	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000874	metal binding site [ion binding]; metal-binding site
656519000875	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519000876	active site
656519000877	I-site; other site
656519000878	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000879	Zn2+ binding site [ion binding]; other site
656519000880	Mg2+ binding site [ion binding]; other site
656519000881	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
656519000882	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
656519000883	dimer interface [polypeptide binding]; other site
656519000884	active site
656519000885	metal binding site [ion binding]; metal-binding site
656519000886	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
656519000887	intersubunit interface [polypeptide binding]; other site
656519000888	active site
656519000889	catalytic residue [active]
656519000890	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519000891	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
656519000892	N- and C-terminal domain interface [polypeptide binding]; other site
656519000893	active site
656519000894	MgATP binding site [chemical binding]; other site
656519000895	catalytic site [active]
656519000896	metal binding site [ion binding]; metal-binding site
656519000897	xylulose binding site [chemical binding]; other site
656519000898	putative homodimer interface [polypeptide binding]; other site
656519000899	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
656519000900	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
656519000901	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
656519000902	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
656519000903	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
656519000904	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519000905	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
656519000906	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519000907	Walker A/P-loop; other site
656519000908	ATP binding site [chemical binding]; other site
656519000909	Q-loop/lid; other site
656519000910	ABC transporter signature motif; other site
656519000911	Walker B; other site
656519000912	D-loop; other site
656519000913	H-loop/switch region; other site
656519000914	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519000915	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
656519000916	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519000917	Walker A/P-loop; other site
656519000918	ATP binding site [chemical binding]; other site
656519000919	Q-loop/lid; other site
656519000920	ABC transporter signature motif; other site
656519000921	Walker B; other site
656519000922	D-loop; other site
656519000923	H-loop/switch region; other site
656519000924	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519000925	dimerization interface [polypeptide binding]; other site
656519000926	putative DNA binding site [nucleotide binding]; other site
656519000927	putative Zn2+ binding site [ion binding]; other site
656519000928	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519000929	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519000930	Integrase core domain; Region: rve; pfam00665
656519000931	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
656519000932	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
656519000933	Domain of unknown function DUF11; Region: DUF11; pfam01345
656519000934	Domain of unknown function DUF11; Region: DUF11; pfam01345
656519000935	Domain of unknown function DUF11; Region: DUF11; pfam01345
656519000936	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000937	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
656519000938	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000939	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000940	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
656519000941	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000942	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000943	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
656519000944	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000945	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
656519000946	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
656519000947	short chain dehydrogenase; Provisional; Region: PRK06197
656519000948	putative NAD(P) binding site [chemical binding]; other site
656519000949	active site
656519000950	PAS domain; Region: PAS_9; pfam13426
656519000951	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519000952	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519000953	metal binding site [ion binding]; metal-binding site
656519000954	active site
656519000955	I-site; other site
656519000956	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
656519000957	Probable transposase; Region: OrfB_IS605; pfam01385
656519000958	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
656519000959	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519000960	Response regulator receiver domain; Region: Response_reg; pfam00072
656519000961	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
656519000962	active site
656519000963	phosphorylation site [posttranslational modification]
656519000964	intermolecular recognition site; other site
656519000965	dimerization interface [polypeptide binding]; other site
656519000966	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
656519000967	GAF domain; Region: GAF; pfam01590
656519000968	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519000969	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519000970	Zn2+ binding site [ion binding]; other site
656519000971	Mg2+ binding site [ion binding]; other site
656519000972	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
656519000973	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
656519000974	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
656519000975	catalytic core [active]
656519000976	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
656519000977	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
656519000978	homodimer interface [polypeptide binding]; other site
656519000979	substrate-cofactor binding pocket; other site
656519000980	catalytic residue [active]
656519000981	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
656519000982	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
656519000983	Tetramer interface [polypeptide binding]; other site
656519000984	active site
656519000985	FMN-binding site [chemical binding]; other site
656519000986	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
656519000987	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
656519000988	putative NAD(P) binding site [chemical binding]; other site
656519000989	catalytic Zn binding site [ion binding]; other site
656519000990	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
656519000991	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
656519000992	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
656519000993	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
656519000994	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
656519000995	putative recombination protein RecB; Provisional; Region: PRK13909
656519000996	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
656519000997	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519000998	intersubunit interface [polypeptide binding]; other site
656519000999	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
656519001000	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519001001	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
656519001002	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
656519001003	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
656519001004	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519001005	ABC-ATPase subunit  interface; other site
656519001006	dimer interface [polypeptide binding]; other site
656519001007	putative PBP binding regions; other site
656519001008	HD domain; Region: HD_4; pfam13328
656519001009	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
656519001010	TrkA-C domain; Region: TrkA_C; pfam02080
656519001011	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
656519001012	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
656519001013	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
656519001014	MoaE homodimer interface [polypeptide binding]; other site
656519001015	active site residues [active]
656519001016	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
656519001017	Domain of unknown function DUF77; Region: DUF77; pfam01910
656519001018	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
656519001019	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
656519001020	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519001021	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
656519001022	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519001023	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
656519001024	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
656519001025	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
656519001026	Walker A/P-loop; other site
656519001027	ATP binding site [chemical binding]; other site
656519001028	Q-loop/lid; other site
656519001029	ABC transporter signature motif; other site
656519001030	Walker B; other site
656519001031	D-loop; other site
656519001032	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
656519001033	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
656519001034	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
656519001035	FtsX-like permease family; Region: FtsX; pfam02687
656519001036	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
656519001037	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
656519001038	putative FMN binding site [chemical binding]; other site
656519001039	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
656519001040	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
656519001041	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
656519001042	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
656519001043	Protein of unknown function (DUF1177); Region: DUF1177; pfam06675
656519001044	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519001045	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
656519001046	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519001047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519001048	putative PBP binding loops; other site
656519001049	dimer interface [polypeptide binding]; other site
656519001050	ABC-ATPase subunit interface; other site
656519001051	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
656519001052	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519001053	dimer interface [polypeptide binding]; other site
656519001054	conserved gate region; other site
656519001055	ABC-ATPase subunit interface; other site
656519001056	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
656519001057	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
656519001058	Walker A/P-loop; other site
656519001059	ATP binding site [chemical binding]; other site
656519001060	Q-loop/lid; other site
656519001061	ABC transporter signature motif; other site
656519001062	Walker B; other site
656519001063	D-loop; other site
656519001064	H-loop/switch region; other site
656519001065	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
656519001066	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
656519001067	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
656519001068	Walker A/P-loop; other site
656519001069	ATP binding site [chemical binding]; other site
656519001070	Q-loop/lid; other site
656519001071	ABC transporter signature motif; other site
656519001072	Walker B; other site
656519001073	D-loop; other site
656519001074	H-loop/switch region; other site
656519001075	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
656519001076	Predicted amidohydrolase [General function prediction only]; Region: COG0388
656519001077	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
656519001078	active site
656519001079	catalytic triad [active]
656519001080	dimer interface [polypeptide binding]; other site
656519001081	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
656519001082	nudix motif; other site
656519001083	6-phosphofructokinase; Provisional; Region: PRK14072
656519001084	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
656519001085	active site
656519001086	ADP/pyrophosphate binding site [chemical binding]; other site
656519001087	dimerization interface [polypeptide binding]; other site
656519001088	allosteric effector site; other site
656519001089	fructose-1,6-bisphosphate binding site; other site
656519001090	Class I aldolases; Region: Aldolase_Class_I; cl17187
656519001091	catalytic residue [active]
656519001092	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
656519001093	Thermostable 8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: COG1059
656519001094	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
656519001095	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
656519001096	putative NAD(P) binding site [chemical binding]; other site
656519001097	putative active site [active]
656519001098	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
656519001099	catalytic residue [active]
656519001100	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
656519001101	GAF domain; Region: GAF; pfam01590
656519001102	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
656519001103	allantoate amidohydrolase; Reviewed; Region: PRK09290
656519001104	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
656519001105	active site
656519001106	metal binding site [ion binding]; metal-binding site
656519001107	dimer interface [polypeptide binding]; other site
656519001108	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
656519001109	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
656519001110	metal binding site [ion binding]; metal-binding site
656519001111	putative dimer interface [polypeptide binding]; other site
656519001112	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
656519001113	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
656519001114	metal binding site [ion binding]; metal-binding site
656519001115	putative dimer interface [polypeptide binding]; other site
656519001116	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
656519001117	active site
656519001118	DNA binding site [nucleotide binding]
656519001119	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
656519001120	active site
656519001121	catalytic residues [active]
656519001122	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
656519001123	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
656519001124	CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704
656519001125	Pirin-related protein [General function prediction only]; Region: COG1741
656519001126	Pirin; Region: Pirin; pfam02678
656519001127	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
656519001128	PAS domain S-box; Region: sensory_box; TIGR00229
656519001129	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
656519001130	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001131	putative active site [active]
656519001132	heme pocket [chemical binding]; other site
656519001133	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001134	putative active site [active]
656519001135	heme pocket [chemical binding]; other site
656519001136	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001137	PAS fold; Region: PAS_3; pfam08447
656519001138	putative active site [active]
656519001139	heme pocket [chemical binding]; other site
656519001140	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519001141	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001142	metal binding site [ion binding]; metal-binding site
656519001143	active site
656519001144	I-site; other site
656519001145	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519001146	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001147	Zn2+ binding site [ion binding]; other site
656519001148	Mg2+ binding site [ion binding]; other site
656519001149	CoA binding domain; Region: CoA_binding_2; pfam13380
656519001150	PAS domain; Region: PAS; smart00091
656519001151	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
656519001152	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
656519001153	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519001154	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001155	metal binding site [ion binding]; metal-binding site
656519001156	active site
656519001157	I-site; other site
656519001158	Peptidase family M48; Region: Peptidase_M48; cl12018
656519001159	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
656519001160	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
656519001161	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
656519001162	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
656519001163	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
656519001164	inhibitor-cofactor binding pocket; inhibition site
656519001165	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519001166	catalytic residue [active]
656519001167	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
656519001168	putative FMN binding site [chemical binding]; other site
656519001169	NADPH bind site [chemical binding]; other site
656519001170	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
656519001171	nucleoside/Zn binding site; other site
656519001172	dimer interface [polypeptide binding]; other site
656519001173	catalytic motif [active]
656519001174	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
656519001175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519001176	Walker A motif; other site
656519001177	ATP binding site [chemical binding]; other site
656519001178	Walker B motif; other site
656519001179	arginine finger; other site
656519001180	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
656519001181	hypothetical protein; Validated; Region: PRK00153
656519001182	recombination protein RecR; Reviewed; Region: recR; PRK00076
656519001183	RecR protein; Region: RecR; pfam02132
656519001184	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
656519001185	putative active site [active]
656519001186	putative metal-binding site [ion binding]; other site
656519001187	tetramer interface [polypeptide binding]; other site
656519001188	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
656519001189	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
656519001190	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
656519001191	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
656519001192	active site
656519001193	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
656519001194	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
656519001195	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519001196	thymidylate kinase; Validated; Region: tmk; PRK00698
656519001197	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
656519001198	TMP-binding site; other site
656519001199	ATP-binding site [chemical binding]; other site
656519001200	Protein of unknown function (DUF970); Region: DUF970; cl17525
656519001201	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
656519001202	DNA polymerase III subunit delta'; Validated; Region: PRK08485
656519001203	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
656519001204	Protein of unknown function (DUF972); Region: DUF972; pfam06156
656519001205	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
656519001206	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519001207	S-adenosylmethionine binding site [chemical binding]; other site
656519001208	Predicted methyltransferases [General function prediction only]; Region: COG0313
656519001209	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
656519001210	putative SAM binding site [chemical binding]; other site
656519001211	putative homodimer interface [polypeptide binding]; other site
656519001212	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
656519001213	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
656519001214	active site
656519001215	HIGH motif; other site
656519001216	KMSKS motif; other site
656519001217	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
656519001218	tRNA binding surface [nucleotide binding]; other site
656519001219	anticodon binding site; other site
656519001220	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
656519001221	dimer interface [polypeptide binding]; other site
656519001222	putative tRNA-binding site [nucleotide binding]; other site
656519001223	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
656519001224	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
656519001225	CoA binding domain; Region: CoA_binding; pfam02629
656519001226	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
656519001227	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
656519001228	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
656519001229	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
656519001230	hexamer interface [polypeptide binding]; other site
656519001231	ligand binding site [chemical binding]; other site
656519001232	putative active site [active]
656519001233	NAD(P) binding site [chemical binding]; other site
656519001234	alanine racemase; Reviewed; Region: alr; PRK00053
656519001235	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
656519001236	active site
656519001237	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
656519001238	dimer interface [polypeptide binding]; other site
656519001239	substrate binding site [chemical binding]; other site
656519001240	catalytic residues [active]
656519001241	Methyltransferase domain; Region: Methyltransf_23; pfam13489
656519001242	OsmC-like protein; Region: OsmC; pfam02566
656519001243	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
656519001244	HTH domain; Region: HTH_11; pfam08279
656519001245	3H domain; Region: 3H; pfam02829
656519001246	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
656519001247	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
656519001248	Na binding site [ion binding]; other site
656519001249	Quinolinate synthetase A protein; Region: NadA; pfam02445
656519001250	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
656519001251	L-aspartate oxidase; Provisional; Region: PRK06175
656519001252	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
656519001253	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
656519001254	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
656519001255	dimerization interface [polypeptide binding]; other site
656519001256	active site
656519001257	Quinolinate synthetase A protein; Region: NadA; pfam02445
656519001258	PAS domain S-box; Region: sensory_box; TIGR00229
656519001259	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001260	PAS domain; Region: PAS_9; pfam13426
656519001261	putative active site [active]
656519001262	heme pocket [chemical binding]; other site
656519001263	PAS fold; Region: PAS_3; pfam08447
656519001264	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001265	putative active site [active]
656519001266	PAS fold; Region: PAS_3; pfam08447
656519001267	heme pocket [chemical binding]; other site
656519001268	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
656519001269	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
656519001270	GAF domain; Region: GAF_3; pfam13492
656519001271	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519001272	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001273	metal binding site [ion binding]; metal-binding site
656519001274	active site
656519001275	I-site; other site
656519001276	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519001277	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001278	Zn2+ binding site [ion binding]; other site
656519001279	Mg2+ binding site [ion binding]; other site
656519001280	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
656519001281	Prephenate dehydratase; Region: PDT; pfam00800
656519001282	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
656519001283	putative L-Phe binding site [chemical binding]; other site
656519001284	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
656519001285	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
656519001286	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
656519001287	prephenate dehydrogenase; Validated; Region: PRK08507
656519001288	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
656519001289	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
656519001290	hinge; other site
656519001291	active site
656519001292	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
656519001293	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519001294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519001295	homodimer interface [polypeptide binding]; other site
656519001296	catalytic residue [active]
656519001297	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
656519001298	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
656519001299	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
656519001300	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
656519001301	Tetramer interface [polypeptide binding]; other site
656519001302	active site
656519001303	FMN-binding site [chemical binding]; other site
656519001304	SurA N-terminal domain; Region: SurA_N_3; cl07813
656519001305	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
656519001306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519001307	active site
656519001308	phosphorylation site [posttranslational modification]
656519001309	intermolecular recognition site; other site
656519001310	dimerization interface [polypeptide binding]; other site
656519001311	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
656519001312	DNA binding site [nucleotide binding]
656519001313	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
656519001314	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519001315	dimerization interface [polypeptide binding]; other site
656519001316	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519001317	dimer interface [polypeptide binding]; other site
656519001318	phosphorylation site [posttranslational modification]
656519001319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519001320	ATP binding site [chemical binding]; other site
656519001321	Mg2+ binding site [ion binding]; other site
656519001322	G-X-G motif; other site
656519001323	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
656519001324	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
656519001325	oligomer interface [polypeptide binding]; other site
656519001326	putative active site [active]
656519001327	metal binding site [ion binding]; metal-binding site
656519001328	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
656519001329	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
656519001330	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
656519001331	catalytic residues [active]
656519001332	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
656519001333	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
656519001334	catalytic residues [active]
656519001335	Flavodoxin domain; Region: Flavodoxin_5; cl17428
656519001336	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
656519001337	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
656519001338	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
656519001339	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
656519001340	active site
656519001341	HIGH motif; other site
656519001342	KMSK motif region; other site
656519001343	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
656519001344	tRNA binding surface [nucleotide binding]; other site
656519001345	anticodon binding site; other site
656519001346	CTP synthetase; Validated; Region: pyrG; PRK05380
656519001347	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
656519001348	Catalytic site [active]
656519001349	active site
656519001350	UTP binding site [chemical binding]; other site
656519001351	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
656519001352	active site
656519001353	putative oxyanion hole; other site
656519001354	catalytic triad [active]
656519001355	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
656519001356	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
656519001357	substrate binding site [chemical binding]; other site
656519001358	oxyanion hole (OAH) forming residues; other site
656519001359	trimer interface [polypeptide binding]; other site
656519001360	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
656519001361	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
656519001362	intersubunit interface [polypeptide binding]; other site
656519001363	active site
656519001364	zinc binding site [ion binding]; other site
656519001365	Na+ binding site [ion binding]; other site
656519001366	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
656519001367	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
656519001368	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
656519001369	transcription termination factor Rho; Provisional; Region: rho; PRK09376
656519001370	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
656519001371	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519001372	RNA binding site [nucleotide binding]; other site
656519001373	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
656519001374	multimer interface [polypeptide binding]; other site
656519001375	Walker A motif; other site
656519001376	ATP binding site [chemical binding]; other site
656519001377	Walker B motif; other site
656519001378	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
656519001379	thymidine kinase; Provisional; Region: PRK04296
656519001380	peptide chain release factor 1; Validated; Region: prfA; PRK00591
656519001381	This domain is found in peptide chain release factors; Region: PCRF; smart00937
656519001382	RF-1 domain; Region: RF-1; pfam00472
656519001383	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
656519001384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519001385	S-adenosylmethionine binding site [chemical binding]; other site
656519001386	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
656519001387	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
656519001388	Low molecular weight phosphatase family; Region: LMWPc; cd00115
656519001389	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
656519001390	active site
656519001391	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519001392	active site
656519001393	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
656519001394	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
656519001395	Mg++ binding site [ion binding]; other site
656519001396	putative catalytic motif [active]
656519001397	substrate binding site [chemical binding]; other site
656519001398	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
656519001399	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
656519001400	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
656519001401	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
656519001402	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
656519001403	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
656519001404	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
656519001405	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
656519001406	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
656519001407	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
656519001408	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
656519001409	beta subunit interaction interface [polypeptide binding]; other site
656519001410	Walker A motif; other site
656519001411	ATP binding site [chemical binding]; other site
656519001412	Walker B motif; other site
656519001413	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
656519001414	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
656519001415	core domain interface [polypeptide binding]; other site
656519001416	delta subunit interface [polypeptide binding]; other site
656519001417	epsilon subunit interface [polypeptide binding]; other site
656519001418	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
656519001419	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
656519001420	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
656519001421	alpha subunit interaction interface [polypeptide binding]; other site
656519001422	Walker A motif; other site
656519001423	ATP binding site [chemical binding]; other site
656519001424	Walker B motif; other site
656519001425	inhibitor binding site; inhibition site
656519001426	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
656519001427	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
656519001428	gamma subunit interface [polypeptide binding]; other site
656519001429	epsilon subunit interface [polypeptide binding]; other site
656519001430	LBP interface [polypeptide binding]; other site
656519001431	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
656519001432	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
656519001433	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
656519001434	hinge; other site
656519001435	active site
656519001436	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
656519001437	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
656519001438	substrate binding site [chemical binding]; other site
656519001439	ATP binding site [chemical binding]; other site
656519001440	FOG: CBS domain [General function prediction only]; Region: COG0517
656519001441	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
656519001442	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
656519001443	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
656519001444	rod shape-determining protein MreB; Provisional; Region: PRK13930
656519001445	MreB and similar proteins; Region: MreB_like; cd10225
656519001446	nucleotide binding site [chemical binding]; other site
656519001447	Mg binding site [ion binding]; other site
656519001448	putative protofilament interaction site [polypeptide binding]; other site
656519001449	RodZ interaction site [polypeptide binding]; other site
656519001450	Family of unknown function (DUF490); Region: DUF490; pfam04357
656519001451	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
656519001452	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
656519001453	Surface antigen; Region: Bac_surface_Ag; pfam01103
656519001454	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
656519001455	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
656519001456	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
656519001457	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
656519001458	trimer interface [polypeptide binding]; other site
656519001459	active site
656519001460	UDP-GlcNAc binding site [chemical binding]; other site
656519001461	lipid binding site [chemical binding]; lipid-binding site
656519001462	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
656519001463	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
656519001464	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
656519001465	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
656519001466	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
656519001467	active site
656519001468	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
656519001469	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
656519001470	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
656519001471	OstA-like protein; Region: OstA; cl00844
656519001472	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
656519001473	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
656519001474	Walker A/P-loop; other site
656519001475	ATP binding site [chemical binding]; other site
656519001476	Q-loop/lid; other site
656519001477	ABC transporter signature motif; other site
656519001478	Walker B; other site
656519001479	D-loop; other site
656519001480	H-loop/switch region; other site
656519001481	Predicted permeases [General function prediction only]; Region: COG0795
656519001482	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
656519001483	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
656519001484	Tropomyosin like; Region: Tropomyosin_1; pfam12718
656519001485	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
656519001486	linker region; other site
656519001487	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
656519001488	S-layer homology domain; Region: SLH; pfam00395
656519001489	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
656519001490	Autotransporter beta-domain; Region: Autotransporter; cl17461
656519001491	Winged helix-turn helix; Region: HTH_29; pfam13551
656519001492	Helix-turn-helix domain; Region: HTH_28; pfam13518
656519001493	Integrase core domain; Region: rve; pfam00665
656519001494	S-layer homology domain; Region: SLH; pfam00395
656519001495	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
656519001496	aspartate racemase; Region: asp_race; TIGR00035
656519001497	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
656519001498	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
656519001499	active site
656519001500	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
656519001501	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
656519001502	S-layer homology domain; Region: SLH; pfam00395
656519001503	PAS domain S-box; Region: sensory_box; TIGR00229
656519001504	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001505	putative active site [active]
656519001506	heme pocket [chemical binding]; other site
656519001507	PAS fold; Region: PAS_3; pfam08447
656519001508	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
656519001509	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001510	PAS domain; Region: PAS_9; pfam13426
656519001511	putative active site [active]
656519001512	heme pocket [chemical binding]; other site
656519001513	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001514	PAS domain; Region: PAS_9; pfam13426
656519001515	putative active site [active]
656519001516	heme pocket [chemical binding]; other site
656519001517	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
656519001518	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
656519001519	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519001520	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001521	metal binding site [ion binding]; metal-binding site
656519001522	active site
656519001523	I-site; other site
656519001524	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001525	Zn2+ binding site [ion binding]; other site
656519001526	Mg2+ binding site [ion binding]; other site
656519001527	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
656519001528	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
656519001529	S-layer homology domain; Region: SLH; pfam00395
656519001530	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
656519001531	Probable transposase; Region: OrfB_IS605; pfam01385
656519001532	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
656519001533	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
656519001534	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
656519001535	active site
656519001536	substrate binding site [chemical binding]; other site
656519001537	metal binding site [ion binding]; metal-binding site
656519001538	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
656519001539	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
656519001540	nucleophile elbow; other site
656519001541	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
656519001542	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
656519001543	active site
656519001544	tetramer interface; other site
656519001545	Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031
656519001546	Sporulation related domain; Region: SPOR; pfam05036
656519001547	Stage II sporulation protein; Region: SpoIID; pfam08486
656519001548	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
656519001549	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
656519001550	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
656519001551	putative ribose interaction site [chemical binding]; other site
656519001552	putative ADP binding site [chemical binding]; other site
656519001553	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
656519001554	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
656519001555	active site
656519001556	nucleotide binding site [chemical binding]; other site
656519001557	HIGH motif; other site
656519001558	KMSKS motif; other site
656519001559	RNA polymerase factor sigma-70; Validated; Region: PRK08295
656519001560	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
656519001561	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
656519001562	DNA binding residues [nucleotide binding]
656519001563	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
656519001564	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519001565	active site
656519001566	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
656519001567	30S subunit binding site; other site
656519001568	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
656519001569	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
656519001570	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
656519001571	active site
656519001572	catalytic triad [active]
656519001573	Predicted permeases [General function prediction only]; Region: COG0795
656519001574	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
656519001575	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
656519001576	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
656519001577	OstA-like protein; Region: OstA; cl00844
656519001578	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
656519001579	active site
656519001580	catalytic triad [active]
656519001581	dimer interface [polypeptide binding]; other site
656519001582	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
656519001583	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
656519001584	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
656519001585	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519001586	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519001587	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001588	metal binding site [ion binding]; metal-binding site
656519001589	active site
656519001590	I-site; other site
656519001591	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
656519001592	DEAD/DEAH box helicase; Region: DEAD; pfam00270
656519001593	ATP binding site [chemical binding]; other site
656519001594	putative Mg++ binding site [ion binding]; other site
656519001595	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
656519001596	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
656519001597	nucleotide binding region [chemical binding]; other site
656519001598	ATP-binding site [chemical binding]; other site
656519001599	peptide chain release factor 2; Validated; Region: prfB; PRK00578
656519001600	This domain is found in peptide chain release factors; Region: PCRF; smart00937
656519001601	RF-1 domain; Region: RF-1; pfam00472
656519001602	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
656519001603	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
656519001604	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
656519001605	Uncharacterized conserved protein [Function unknown]; Region: COG1284
656519001606	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
656519001607	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
656519001608	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
656519001609	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
656519001610	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
656519001611	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
656519001612	protein binding site [polypeptide binding]; other site
656519001613	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
656519001614	Catalytic dyad [active]
656519001615	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
656519001616	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
656519001617	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
656519001618	putative L-serine binding site [chemical binding]; other site
656519001619	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
656519001620	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
656519001621	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
656519001622	putative proton transfer pathway, P2; other site
656519001623	excinuclease ABC subunit B; Provisional; Region: PRK05298
656519001624	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
656519001625	ATP binding site [chemical binding]; other site
656519001626	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519001627	nucleotide binding region [chemical binding]; other site
656519001628	ATP-binding site [chemical binding]; other site
656519001629	Ultra-violet resistance protein B; Region: UvrB; pfam12344
656519001630	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
656519001631	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
656519001632	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
656519001633	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
656519001634	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519001635	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
656519001636	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519001637	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
656519001638	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
656519001639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519001640	dimer interface [polypeptide binding]; other site
656519001641	conserved gate region; other site
656519001642	ABC-ATPase subunit interface; other site
656519001643	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
656519001644	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
656519001645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519001646	dimer interface [polypeptide binding]; other site
656519001647	conserved gate region; other site
656519001648	putative PBP binding loops; other site
656519001649	ABC-ATPase subunit interface; other site
656519001650	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
656519001651	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
656519001652	Walker A/P-loop; other site
656519001653	ATP binding site [chemical binding]; other site
656519001654	Q-loop/lid; other site
656519001655	ABC transporter signature motif; other site
656519001656	Walker B; other site
656519001657	D-loop; other site
656519001658	H-loop/switch region; other site
656519001659	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
656519001660	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
656519001661	Walker A/P-loop; other site
656519001662	ATP binding site [chemical binding]; other site
656519001663	Q-loop/lid; other site
656519001664	ABC transporter signature motif; other site
656519001665	Walker B; other site
656519001666	D-loop; other site
656519001667	H-loop/switch region; other site
656519001668	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
656519001669	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
656519001670	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
656519001671	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
656519001672	active site
656519001673	catalytic site [active]
656519001674	metal binding site [ion binding]; metal-binding site
656519001675	dimer interface [polypeptide binding]; other site
656519001676	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
656519001677	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
656519001678	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
656519001679	DctM-like transporters; Region: DctM; pfam06808
656519001680	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
656519001681	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
656519001682	MgtC family; Region: MgtC; pfam02308
656519001683	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
656519001684	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
656519001685	active site
656519001686	catalytic site [active]
656519001687	metal binding site [ion binding]; metal-binding site
656519001688	dimer interface [polypeptide binding]; other site
656519001689	Transposase IS200 like; Region: Y1_Tnp; cl00848
656519001690	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
656519001691	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
656519001692	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
656519001693	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
656519001694	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
656519001695	GIY-YIG motif/motif A; other site
656519001696	active site
656519001697	catalytic site [active]
656519001698	putative DNA binding site [nucleotide binding]; other site
656519001699	metal binding site [ion binding]; metal-binding site
656519001700	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
656519001701	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
656519001702	GSH binding site [chemical binding]; other site
656519001703	catalytic residues [active]
656519001704	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
656519001705	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
656519001706	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519001707	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
656519001708	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
656519001709	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
656519001710	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
656519001711	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
656519001712	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
656519001713	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519001714	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519001715	DNA-binding site [nucleotide binding]; DNA binding site
656519001716	FCD domain; Region: FCD; pfam07729
656519001717	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519001718	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001719	Zn2+ binding site [ion binding]; other site
656519001720	Mg2+ binding site [ion binding]; other site
656519001721	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001722	PAS domain; Region: PAS_9; pfam13426
656519001723	putative active site [active]
656519001724	heme pocket [chemical binding]; other site
656519001725	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519001726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001727	metal binding site [ion binding]; metal-binding site
656519001728	active site
656519001729	I-site; other site
656519001730	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001731	Zn2+ binding site [ion binding]; other site
656519001732	Mg2+ binding site [ion binding]; other site
656519001733	PAS domain; Region: PAS_9; pfam13426
656519001734	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
656519001735	putative active site [active]
656519001736	heme pocket [chemical binding]; other site
656519001737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001738	PAS fold; Region: PAS_3; pfam08447
656519001739	putative active site [active]
656519001740	heme pocket [chemical binding]; other site
656519001741	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
656519001742	The GLUG motif; Region: Glug; pfam07581
656519001743	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
656519001744	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
656519001745	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
656519001746	active site
656519001747	dimer interface [polypeptide binding]; other site
656519001748	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
656519001749	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
656519001750	active site
656519001751	FMN binding site [chemical binding]; other site
656519001752	substrate binding site [chemical binding]; other site
656519001753	3Fe-4S cluster binding site [ion binding]; other site
656519001754	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
656519001755	domain interface; other site
656519001756	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
656519001757	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
656519001758	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
656519001759	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
656519001760	substrate binding pocket [chemical binding]; other site
656519001761	membrane-bound complex binding site; other site
656519001762	hinge residues; other site
656519001763	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
656519001764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519001765	dimer interface [polypeptide binding]; other site
656519001766	conserved gate region; other site
656519001767	putative PBP binding loops; other site
656519001768	ABC-ATPase subunit interface; other site
656519001769	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
656519001770	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
656519001771	Walker A/P-loop; other site
656519001772	ATP binding site [chemical binding]; other site
656519001773	Q-loop/lid; other site
656519001774	ABC transporter signature motif; other site
656519001775	Walker B; other site
656519001776	D-loop; other site
656519001777	H-loop/switch region; other site
656519001778	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519001779	dimer interface [polypeptide binding]; other site
656519001780	conserved gate region; other site
656519001781	putative PBP binding loops; other site
656519001782	ABC-ATPase subunit interface; other site
656519001783	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
656519001784	FAD binding domain; Region: FAD_binding_4; pfam01565
656519001785	Major Facilitator Superfamily; Region: MFS_1; pfam07690
656519001786	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519001787	putative substrate translocation pore; other site
656519001788	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
656519001789	Ligand binding site [chemical binding]; other site
656519001790	Electron transfer flavoprotein domain; Region: ETF; pfam01012
656519001791	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
656519001792	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
656519001793	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
656519001794	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
656519001795	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
656519001796	NADP binding site [chemical binding]; other site
656519001797	homodimer interface [polypeptide binding]; other site
656519001798	active site
656519001799	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519001800	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
656519001801	nucleotide binding site [chemical binding]; other site
656519001802	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
656519001803	nucleotide binding site [chemical binding]; other site
656519001804	BCCT family transporter; Region: BCCT; pfam02028
656519001805	Survival protein SurE; Region: SurE; cl00448
656519001806	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
656519001807	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
656519001808	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
656519001809	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
656519001810	active site
656519001811	nucleophile elbow; other site
656519001812	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
656519001813	active site
656519001814	catalytic site [active]
656519001815	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
656519001816	Response regulator receiver domain; Region: Response_reg; pfam00072
656519001817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519001818	active site
656519001819	phosphorylation site [posttranslational modification]
656519001820	intermolecular recognition site; other site
656519001821	dimerization interface [polypeptide binding]; other site
656519001822	Histidine kinase; Region: His_kinase; pfam06580
656519001823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519001824	ATP binding site [chemical binding]; other site
656519001825	Mg2+ binding site [ion binding]; other site
656519001826	G-X-G motif; other site
656519001827	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519001828	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001829	metal binding site [ion binding]; metal-binding site
656519001830	active site
656519001831	I-site; other site
656519001832	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
656519001833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519001834	active site
656519001835	phosphorylation site [posttranslational modification]
656519001836	intermolecular recognition site; other site
656519001837	dimerization interface [polypeptide binding]; other site
656519001838	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
656519001839	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519001840	active site
656519001841	phosphorylation site [posttranslational modification]
656519001842	intermolecular recognition site; other site
656519001843	dimerization interface [polypeptide binding]; other site
656519001844	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
656519001845	FecR protein; Region: FecR; pfam04773
656519001846	PAS domain; Region: PAS_9; pfam13426
656519001847	PAS domain; Region: PAS; smart00091
656519001848	PAS domain; Region: PAS_9; pfam13426
656519001849	putative active site [active]
656519001850	heme pocket [chemical binding]; other site
656519001851	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
656519001852	GAF domain; Region: GAF_3; pfam13492
656519001853	PAS domain S-box; Region: sensory_box; TIGR00229
656519001854	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519001855	putative active site [active]
656519001856	heme pocket [chemical binding]; other site
656519001857	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519001858	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519001859	metal binding site [ion binding]; metal-binding site
656519001860	active site
656519001861	I-site; other site
656519001862	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519001863	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519001864	Zn2+ binding site [ion binding]; other site
656519001865	Mg2+ binding site [ion binding]; other site
656519001866	putative transposase OrfB; Reviewed; Region: PHA02517
656519001867	HTH-like domain; Region: HTH_21; pfam13276
656519001868	Integrase core domain; Region: rve; pfam00665
656519001869	Integrase core domain; Region: rve_3; pfam13683
656519001870	Transposase; Region: HTH_Tnp_1; pfam01527
656519001871	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519001872	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
656519001873	active site
656519001874	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
656519001875	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
656519001876	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
656519001877	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
656519001878	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
656519001879	putative active site [active]
656519001880	putative NTP binding site [chemical binding]; other site
656519001881	putative nucleic acid binding site [nucleotide binding]; other site
656519001882	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
656519001883	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
656519001884	The GLUG motif; Region: Glug; pfam07581
656519001885	Transposase; Region: HTH_Tnp_1; pfam01527
656519001886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519001887	putative transposase OrfB; Reviewed; Region: PHA02517
656519001888	HTH-like domain; Region: HTH_21; pfam13276
656519001889	Integrase core domain; Region: rve; pfam00665
656519001890	Integrase core domain; Region: rve_3; pfam13683
656519001891	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
656519001892	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
656519001893	Chain length determinant protein; Region: Wzz; pfam02706
656519001894	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
656519001895	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
656519001896	Chain length determinant protein; Region: Wzz; cl15801
656519001897	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
656519001898	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
656519001899	SLBB domain; Region: SLBB; pfam10531
656519001900	SLBB domain; Region: SLBB; pfam10531
656519001901	SLBB domain; Region: SLBB; pfam10531
656519001902	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
656519001903	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
656519001904	SEC-C motif; Region: SEC-C; pfam02810
656519001905	Propionate catabolism activator; Region: PrpR_N; pfam06506
656519001906	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
656519001907	PAS domain; Region: PAS; smart00091
656519001908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519001909	Walker A motif; other site
656519001910	ATP binding site [chemical binding]; other site
656519001911	Walker B motif; other site
656519001912	arginine finger; other site
656519001913	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
656519001914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
656519001915	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
656519001916	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
656519001917	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
656519001918	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
656519001919	inhibitor site; inhibition site
656519001920	active site
656519001921	dimer interface [polypeptide binding]; other site
656519001922	catalytic residue [active]
656519001923	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519001924	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
656519001925	putative active site [active]
656519001926	metal binding site [ion binding]; metal-binding site
656519001927	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
656519001928	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
656519001929	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
656519001930	DctM-like transporters; Region: DctM; pfam06808
656519001931	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
656519001932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519001933	putative substrate translocation pore; other site
656519001934	Major Facilitator Superfamily; Region: MFS_1; pfam07690
656519001935	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
656519001936	classical (c) SDRs; Region: SDR_c; cd05233
656519001937	NAD(P) binding site [chemical binding]; other site
656519001938	active site
656519001939	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
656519001940	BNR repeat-like domain; Region: BNR_2; pfam13088
656519001941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519001942	Transposase; Region: HTH_Tnp_1; pfam01527
656519001943	HTH-like domain; Region: HTH_21; pfam13276
656519001944	Integrase core domain; Region: rve; pfam00665
656519001945	Integrase core domain; Region: rve_3; pfam13683
656519001946	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519001947	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
656519001948	putative ADP-binding pocket [chemical binding]; other site
656519001949	Bacterial sugar transferase; Region: Bac_transf; pfam02397
656519001950	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
656519001951	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
656519001952	inhibitor-cofactor binding pocket; inhibition site
656519001953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519001954	catalytic residue [active]
656519001955	Transposase; Region: HTH_Tnp_1; pfam01527
656519001956	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519001957	putative transposase OrfB; Reviewed; Region: PHA02517
656519001958	HTH-like domain; Region: HTH_21; pfam13276
656519001959	Integrase core domain; Region: rve; pfam00665
656519001960	Integrase core domain; Region: rve_3; pfam13683
656519001961	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
656519001962	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519001963	putative ADP-binding pocket [chemical binding]; other site
656519001964	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519001965	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519001966	Integrase core domain; Region: rve; pfam00665
656519001967	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
656519001968	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519001969	NAD(P) binding site [chemical binding]; other site
656519001970	active site
656519001971	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
656519001972	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
656519001973	Substrate binding site; other site
656519001974	Cupin domain; Region: Cupin_2; cl17218
656519001975	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
656519001976	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
656519001977	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
656519001978	ATP binding site [chemical binding]; other site
656519001979	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
656519001980	putative Mg++ binding site [ion binding]; other site
656519001981	helicase superfamily c-terminal domain; Region: HELICc; smart00490
656519001982	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519001983	Transposase; Region: HTH_Tnp_1; pfam01527
656519001984	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
656519001985	ADP-ribose binding site [chemical binding]; other site
656519001986	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
656519001987	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
656519001988	non-specific DNA binding site [nucleotide binding]; other site
656519001989	salt bridge; other site
656519001990	sequence-specific DNA binding site [nucleotide binding]; other site
656519001991	Domain of unknown function (DUF955); Region: DUF955; pfam06114
656519001992	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
656519001993	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
656519001994	non-specific DNA binding site [nucleotide binding]; other site
656519001995	salt bridge; other site
656519001996	sequence-specific DNA binding site [nucleotide binding]; other site
656519001997	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
656519001998	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
656519001999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519002000	Transposase; Region: HTH_Tnp_1; pfam01527
656519002001	HTH-like domain; Region: HTH_21; pfam13276
656519002002	Integrase core domain; Region: rve; pfam00665
656519002003	Integrase core domain; Region: rve_3; pfam13683
656519002004	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
656519002005	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
656519002006	NAD(P) binding site [chemical binding]; other site
656519002007	homodimer interface [polypeptide binding]; other site
656519002008	substrate binding site [chemical binding]; other site
656519002009	active site
656519002010	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
656519002011	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
656519002012	transposase; Provisional; Region: PRK06526
656519002013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002014	Walker A motif; other site
656519002015	ATP binding site [chemical binding]; other site
656519002016	Walker B motif; other site
656519002017	Transposase IS200 like; Region: Y1_Tnp; pfam01797
656519002018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519002019	Transposase; Region: HTH_Tnp_1; pfam01527
656519002020	Nucleopolyhedrovirus P10 protein; Region: NPV_P10; cl17484
656519002021	putative transposase OrfB; Reviewed; Region: PHA02517
656519002022	HTH-like domain; Region: HTH_21; pfam13276
656519002023	Integrase core domain; Region: rve; pfam00665
656519002024	Integrase core domain; Region: rve_3; pfam13683
656519002025	Transposase; Region: HTH_Tnp_1; pfam01527
656519002026	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519002027	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
656519002028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519002029	active site
656519002030	phosphorylation site [posttranslational modification]
656519002031	intermolecular recognition site; other site
656519002032	dimerization interface [polypeptide binding]; other site
656519002033	LytTr DNA-binding domain; Region: LytTR; smart00850
656519002034	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
656519002035	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
656519002036	Histidine kinase; Region: His_kinase; pfam06580
656519002037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519002038	ATP binding site [chemical binding]; other site
656519002039	Mg2+ binding site [ion binding]; other site
656519002040	G-X-G motif; other site
656519002041	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424
656519002042	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
656519002043	Probable transposase; Region: OrfB_IS605; pfam01385
656519002044	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
656519002045	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424
656519002046	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
656519002047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002048	Walker A motif; other site
656519002049	ATP binding site [chemical binding]; other site
656519002050	Walker B motif; other site
656519002051	arginine finger; other site
656519002052	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
656519002053	hypothetical protein; Provisional; Region: PRK02399
656519002054	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
656519002055	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
656519002056	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
656519002057	transmembrane helices; other site
656519002058	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
656519002059	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
656519002060	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519002061	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
656519002062	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519002063	Walker A/P-loop; other site
656519002064	ATP binding site [chemical binding]; other site
656519002065	Q-loop/lid; other site
656519002066	ABC transporter signature motif; other site
656519002067	Walker B; other site
656519002068	D-loop; other site
656519002069	H-loop/switch region; other site
656519002070	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
656519002071	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519002072	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519002073	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
656519002074	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
656519002075	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
656519002076	substrate binding site; other site
656519002077	tetramer interface; other site
656519002078	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
656519002079	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
656519002080	NAD binding site [chemical binding]; other site
656519002081	putative substrate binding site 2 [chemical binding]; other site
656519002082	putative substrate binding site 1 [chemical binding]; other site
656519002083	active site
656519002084	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
656519002085	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
656519002086	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
656519002087	active site
656519002088	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
656519002089	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
656519002090	NADP binding site [chemical binding]; other site
656519002091	active site
656519002092	putative substrate binding site [chemical binding]; other site
656519002093	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
656519002094	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
656519002095	Probable Catalytic site; other site
656519002096	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
656519002097	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
656519002098	Probable Catalytic site; other site
656519002099	metal-binding site
656519002100	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
656519002101	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
656519002102	NAD binding site [chemical binding]; other site
656519002103	substrate binding site [chemical binding]; other site
656519002104	homodimer interface [polypeptide binding]; other site
656519002105	active site
656519002106	O-Antigen ligase; Region: Wzy_C; pfam04932
656519002107	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
656519002108	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
656519002109	DXD motif; other site
656519002110	Bacterial sugar transferase; Region: Bac_transf; pfam02397
656519002111	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
656519002112	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
656519002113	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
656519002114	Methyltransferase domain; Region: Methyltransf_31; pfam13847
656519002115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519002116	S-adenosylmethionine binding site [chemical binding]; other site
656519002117	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519002118	putative DNA binding site [nucleotide binding]; other site
656519002119	putative Zn2+ binding site [ion binding]; other site
656519002120	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
656519002121	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002122	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
656519002123	Walker A motif; other site
656519002124	ATP binding site [chemical binding]; other site
656519002125	Walker B motif; other site
656519002126	arginine finger; other site
656519002127	PRD domain; Region: PRD; pfam00874
656519002128	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
656519002129	active pocket/dimerization site; other site
656519002130	active site
656519002131	phosphorylation site [posttranslational modification]
656519002132	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519002133	active site
656519002134	phosphorylation site [posttranslational modification]
656519002135	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519002136	active site
656519002137	phosphorylation site [posttranslational modification]
656519002138	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
656519002139	active site
656519002140	P-loop; other site
656519002141	phosphorylation site [posttranslational modification]
656519002142	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
656519002143	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
656519002144	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
656519002145	intersubunit interface [polypeptide binding]; other site
656519002146	active site
656519002147	Zn2+ binding site [ion binding]; other site
656519002148	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
656519002149	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
656519002150	Substrate binding site; other site
656519002151	Cupin domain; Region: Cupin_2; cl17218
656519002152	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
656519002153	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519002154	putative DNA binding site [nucleotide binding]; other site
656519002155	putative Zn2+ binding site [ion binding]; other site
656519002156	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
656519002157	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
656519002158	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
656519002159	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
656519002160	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
656519002161	Walker A/P-loop; other site
656519002162	ATP binding site [chemical binding]; other site
656519002163	Q-loop/lid; other site
656519002164	ABC transporter signature motif; other site
656519002165	Walker B; other site
656519002166	D-loop; other site
656519002167	H-loop/switch region; other site
656519002168	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
656519002169	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
656519002170	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
656519002171	TM-ABC transporter signature motif; other site
656519002172	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
656519002173	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
656519002174	substrate binding site [chemical binding]; other site
656519002175	active site
656519002176	catalytic residues [active]
656519002177	heterodimer interface [polypeptide binding]; other site
656519002178	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519002179	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
656519002180	N- and C-terminal domain interface [polypeptide binding]; other site
656519002181	active site
656519002182	MgATP binding site [chemical binding]; other site
656519002183	catalytic site [active]
656519002184	metal binding site [ion binding]; metal-binding site
656519002185	xylulose binding site [chemical binding]; other site
656519002186	putative homodimer interface [polypeptide binding]; other site
656519002187	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519002188	FMN binding site [chemical binding]; other site
656519002189	dimer interface [polypeptide binding]; other site
656519002190	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519002191	dimer interface [polypeptide binding]; other site
656519002192	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
656519002193	MgtE intracellular N domain; Region: MgtE_N; smart00924
656519002194	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
656519002195	Divalent cation transporter; Region: MgtE; pfam01769
656519002196	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
656519002197	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
656519002198	active site
656519002199	catalytic tetrad [active]
656519002200	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
656519002201	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519002202	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519002203	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
656519002204	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519002205	DNA-binding site [nucleotide binding]; DNA binding site
656519002206	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
656519002207	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519002208	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
656519002209	dimer interface [polypeptide binding]; other site
656519002210	active site
656519002211	metal binding site [ion binding]; metal-binding site
656519002212	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
656519002213	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
656519002214	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
656519002215	active site
656519002216	intersubunit interactions; other site
656519002217	catalytic residue [active]
656519002218	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
656519002219	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
656519002220	TPP-binding site [chemical binding]; other site
656519002221	dimer interface [polypeptide binding]; other site
656519002222	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
656519002223	PYR/PP interface [polypeptide binding]; other site
656519002224	dimer interface [polypeptide binding]; other site
656519002225	TPP binding site [chemical binding]; other site
656519002226	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519002227	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
656519002228	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
656519002229	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
656519002230	NAD(P) binding site [chemical binding]; other site
656519002231	active site
656519002232	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519002233	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
656519002234	N- and C-terminal domain interface [polypeptide binding]; other site
656519002235	putative active site [active]
656519002236	MgATP binding site [chemical binding]; other site
656519002237	catalytic site [active]
656519002238	metal binding site [ion binding]; metal-binding site
656519002239	putative xylulose binding site [chemical binding]; other site
656519002240	putative homodimer interface [polypeptide binding]; other site
656519002241	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
656519002242	intersubunit interface [polypeptide binding]; other site
656519002243	active site
656519002244	zinc binding site [ion binding]; other site
656519002245	Na+ binding site [ion binding]; other site
656519002246	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
656519002247	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
656519002248	putative NAD(P) binding site [chemical binding]; other site
656519002249	catalytic Zn binding site [ion binding]; other site
656519002250	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
656519002251	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519002252	DNA-binding site [nucleotide binding]; DNA binding site
656519002253	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
656519002254	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
656519002255	active site
656519002256	metal binding site [ion binding]; metal-binding site
656519002257	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
656519002258	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519002259	active site
656519002260	motif I; other site
656519002261	motif II; other site
656519002262	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519002263	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
656519002264	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
656519002265	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
656519002266	Sulfatase; Region: Sulfatase; pfam00884
656519002267	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
656519002268	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
656519002269	active site
656519002270	catalytic site [active]
656519002271	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
656519002272	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
656519002273	dimer interface [polypeptide binding]; other site
656519002274	active site
656519002275	metal binding site [ion binding]; metal-binding site
656519002276	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
656519002277	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
656519002278	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
656519002279	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
656519002280	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
656519002281	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
656519002282	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12667
656519002283	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
656519002284	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144
656519002285	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
656519002286	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
656519002287	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
656519002288	metal binding site [ion binding]; metal-binding site
656519002289	dimer interface [polypeptide binding]; other site
656519002290	aminotransferase AlaT; Validated; Region: PRK09265
656519002291	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519002292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519002293	homodimer interface [polypeptide binding]; other site
656519002294	catalytic residue [active]
656519002295	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
656519002296	Catalytic site; other site
656519002297	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
656519002298	DctM-like transporters; Region: DctM; pfam06808
656519002299	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
656519002300	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
656519002301	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
656519002302	membrane-bound complex binding site; other site
656519002303	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
656519002304	Sulfate transporter family; Region: Sulfate_transp; pfam00916
656519002305	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
656519002306	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
656519002307	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519002308	FeS/SAM binding site; other site
656519002309	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
656519002310	biotin synthase; Provisional; Region: PRK07094
656519002311	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519002312	FeS/SAM binding site; other site
656519002313	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
656519002314	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
656519002315	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
656519002316	Sulfate transporter family; Region: Sulfate_transp; pfam00916
656519002317	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
656519002318	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
656519002319	transmembrane helices; other site
656519002320	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
656519002321	TrkA-C domain; Region: TrkA_C; pfam02080
656519002322	TrkA-C domain; Region: TrkA_C; pfam02080
656519002323	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
656519002324	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
656519002325	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
656519002326	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
656519002327	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
656519002328	dimer interface [polypeptide binding]; other site
656519002329	substrate binding site [chemical binding]; other site
656519002330	ATP binding site [chemical binding]; other site
656519002331	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
656519002332	thiamine phosphate binding site [chemical binding]; other site
656519002333	active site
656519002334	pyrophosphate binding site [ion binding]; other site
656519002335	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
656519002336	substrate binding site [chemical binding]; other site
656519002337	multimerization interface [polypeptide binding]; other site
656519002338	ATP binding site [chemical binding]; other site
656519002339	Methyltransferase domain; Region: Methyltransf_23; pfam13489
656519002340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519002341	S-adenosylmethionine binding site [chemical binding]; other site
656519002342	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
656519002343	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
656519002344	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519002345	FeS/SAM binding site; other site
656519002346	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
656519002347	Transposase domain (DUF772); Region: DUF772; pfam05598
656519002348	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
656519002349	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
656519002350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002351	Walker A motif; other site
656519002352	ATP binding site [chemical binding]; other site
656519002353	Walker B motif; other site
656519002354	arginine finger; other site
656519002355	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
656519002356	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
656519002357	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
656519002358	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
656519002359	Domain of unknown function (DUF336); Region: DUF336; pfam03928
656519002360	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
656519002361	4Fe-4S binding domain; Region: Fer4; pfam00037
656519002362	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
656519002363	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
656519002364	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
656519002365	Ubiquitin-like proteins; Region: UBQ; cl00155
656519002366	charged pocket; other site
656519002367	hydrophobic patch; other site
656519002368	hypothetical protein; Provisional; Region: PRK08328
656519002369	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
656519002370	ATP binding site [chemical binding]; other site
656519002371	substrate interface [chemical binding]; other site
656519002372	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
656519002373	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
656519002374	Uncharacterized conserved protein [Function unknown]; Region: COG3342
656519002375	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
656519002376	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519002377	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
656519002378	putative substrate binding site [chemical binding]; other site
656519002379	putative ATP binding site [chemical binding]; other site
656519002380	argininosuccinate synthase; Provisional; Region: PRK13820
656519002381	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
656519002382	ANP binding site [chemical binding]; other site
656519002383	Substrate Binding Site II [chemical binding]; other site
656519002384	Substrate Binding Site I [chemical binding]; other site
656519002385	argininosuccinate lyase; Provisional; Region: PRK00855
656519002386	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
656519002387	active sites [active]
656519002388	tetramer interface [polypeptide binding]; other site
656519002389	Peptidase family M48; Region: Peptidase_M48; cl12018
656519002390	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
656519002391	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
656519002392	Cl- selectivity filter; other site
656519002393	Cl- binding residues [ion binding]; other site
656519002394	pore gating glutamate residue; other site
656519002395	dimer interface [polypeptide binding]; other site
656519002396	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
656519002397	TrkA-N domain; Region: TrkA_N; pfam02254
656519002398	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519002399	dimerization interface [polypeptide binding]; other site
656519002400	putative DNA binding site [nucleotide binding]; other site
656519002401	putative Zn2+ binding site [ion binding]; other site
656519002402	I/LWEQ domain; Region: ILWEQ; smart00307
656519002403	Transposase IS200 like; Region: Y1_Tnp; pfam01797
656519002404	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519002405	MULE transposase domain; Region: MULE; pfam10551
656519002406	Transposase; Region: DDE_Tnp_ISL3; pfam01610
656519002407	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519002408	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
656519002409	substrate binding site [chemical binding]; other site
656519002410	ATP binding site [chemical binding]; other site
656519002411	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
656519002412	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
656519002413	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
656519002414	Transcriptional regulator [Transcription]; Region: IclR; COG1414
656519002415	Bacterial transcriptional regulator; Region: IclR; pfam01614
656519002416	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
656519002417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
656519002418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
656519002419	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
656519002420	fumarate hydratase; Reviewed; Region: fumC; PRK00485
656519002421	Class II fumarases; Region: Fumarase_classII; cd01362
656519002422	active site
656519002423	tetramer interface [polypeptide binding]; other site
656519002424	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519002425	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519002426	Zn2+ binding site [ion binding]; other site
656519002427	Mg2+ binding site [ion binding]; other site
656519002428	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519002429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
656519002430	Cupin domain; Region: Cupin_2; pfam07883
656519002431	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
656519002432	Outer membrane efflux protein; Region: OEP; pfam02321
656519002433	Outer membrane efflux protein; Region: OEP; pfam02321
656519002434	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
656519002435	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
656519002436	HlyD family secretion protein; Region: HlyD_3; pfam13437
656519002437	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
656519002438	Protein export membrane protein; Region: SecD_SecF; cl14618
656519002439	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
656519002440	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
656519002441	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
656519002442	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
656519002443	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
656519002444	feedback inhibition sensing region; other site
656519002445	homohexameric interface [polypeptide binding]; other site
656519002446	nucleotide binding site [chemical binding]; other site
656519002447	N-acetyl-L-glutamate binding site [chemical binding]; other site
656519002448	acetylornithine aminotransferase; Provisional; Region: PRK02627
656519002449	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
656519002450	inhibitor-cofactor binding pocket; inhibition site
656519002451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519002452	catalytic residue [active]
656519002453	SEC-C motif; Region: SEC-C; pfam02810
656519002454	Predicted membrane protein [Function unknown]; Region: COG4684
656519002455	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
656519002456	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
656519002457	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
656519002458	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519002459	motif II; other site
656519002460	Mechanosensitive ion channel; Region: MS_channel; pfam00924
656519002461	DJ-1 family protein; Region: not_thiJ; TIGR01383
656519002462	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
656519002463	conserved cys residue [active]
656519002464	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
656519002465	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
656519002466	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
656519002467	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
656519002468	putative ADP-binding pocket [chemical binding]; other site
656519002469	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
656519002470	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
656519002471	substrate binding site [chemical binding]; other site
656519002472	ATP binding site [chemical binding]; other site
656519002473	pullulanase, type I; Region: pulA_typeI; TIGR02104
656519002474	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
656519002475	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
656519002476	Ca binding site [ion binding]; other site
656519002477	active site
656519002478	catalytic site [active]
656519002479	Pleckstrin homology-like domain; Region: PH-like; cl17171
656519002480	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
656519002481	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
656519002482	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
656519002483	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
656519002484	ligand binding site; other site
656519002485	oligomer interface; other site
656519002486	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
656519002487	dimer interface [polypeptide binding]; other site
656519002488	N-terminal domain interface [polypeptide binding]; other site
656519002489	sulfate 1 binding site; other site
656519002490	glycogen branching enzyme; Provisional; Region: PRK12313
656519002491	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
656519002492	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
656519002493	active site
656519002494	catalytic site [active]
656519002495	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
656519002496	glycogen synthase; Provisional; Region: glgA; PRK00654
656519002497	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
656519002498	ADP-binding pocket [chemical binding]; other site
656519002499	homodimer interface [polypeptide binding]; other site
656519002500	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
656519002501	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
656519002502	trimer interface [polypeptide binding]; other site
656519002503	hexamer (dimer of trimers) interface [polypeptide binding]; other site
656519002504	substrate binding site [chemical binding]; other site
656519002505	Mn binding site [ion binding]; other site
656519002506	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
656519002507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519002508	Walker A/P-loop; other site
656519002509	ATP binding site [chemical binding]; other site
656519002510	Q-loop/lid; other site
656519002511	ABC transporter signature motif; other site
656519002512	Walker B; other site
656519002513	D-loop; other site
656519002514	H-loop/switch region; other site
656519002515	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
656519002516	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
656519002517	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
656519002518	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
656519002519	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
656519002520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002521	dimer interface [polypeptide binding]; other site
656519002522	conserved gate region; other site
656519002523	putative PBP binding loops; other site
656519002524	ABC-ATPase subunit interface; other site
656519002525	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
656519002526	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519002527	Walker A/P-loop; other site
656519002528	ATP binding site [chemical binding]; other site
656519002529	Q-loop/lid; other site
656519002530	ABC transporter signature motif; other site
656519002531	Walker B; other site
656519002532	D-loop; other site
656519002533	H-loop/switch region; other site
656519002534	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
656519002535	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
656519002536	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
656519002537	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519002538	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519002539	Uncharacterized conserved protein [Function unknown]; Region: COG3461
656519002540	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
656519002541	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519002542	FeS/SAM binding site; other site
656519002543	Radical SAM superfamily; Region: Radical_SAM; pfam04055
656519002544	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
656519002545	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
656519002546	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519002547	catalytic residue [active]
656519002548	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519002549	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519002550	catalytic residue [active]
656519002551	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
656519002552	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
656519002553	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
656519002554	FeS/SAM binding site; other site
656519002555	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
656519002556	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
656519002557	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
656519002558	active site
656519002559	homodimer interface [polypeptide binding]; other site
656519002560	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
656519002561	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
656519002562	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
656519002563	dimer interface [polypeptide binding]; other site
656519002564	PYR/PP interface [polypeptide binding]; other site
656519002565	TPP binding site [chemical binding]; other site
656519002566	substrate binding site [chemical binding]; other site
656519002567	2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869
656519002568	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
656519002569	TPP-binding site [chemical binding]; other site
656519002570	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
656519002571	Uncharacterized conserved protein [Function unknown]; Region: COG1633
656519002572	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
656519002573	diiron binding motif [ion binding]; other site
656519002574	hybrid cluster protein; Provisional; Region: PRK05290
656519002575	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519002576	ACS interaction site; other site
656519002577	CODH interaction site; other site
656519002578	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
656519002579	hybrid metal cluster; other site
656519002580	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
656519002581	active site
656519002582	catalytic residues [active]
656519002583	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
656519002584	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
656519002585	G1 box; other site
656519002586	GTP/Mg2+ binding site [chemical binding]; other site
656519002587	Switch I region; other site
656519002588	G2 box; other site
656519002589	Switch II region; other site
656519002590	G3 box; other site
656519002591	G4 box; other site
656519002592	G5 box; other site
656519002593	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
656519002594	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
656519002595	Walker A/P-loop; other site
656519002596	ATP binding site [chemical binding]; other site
656519002597	Q-loop/lid; other site
656519002598	ABC transporter signature motif; other site
656519002599	Walker B; other site
656519002600	D-loop; other site
656519002601	H-loop/switch region; other site
656519002602	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
656519002603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002604	dimer interface [polypeptide binding]; other site
656519002605	conserved gate region; other site
656519002606	ABC-ATPase subunit interface; other site
656519002607	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
656519002608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002609	dimer interface [polypeptide binding]; other site
656519002610	conserved gate region; other site
656519002611	ABC-ATPase subunit interface; other site
656519002612	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
656519002613	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
656519002614	Aspartase; Region: Aspartase; cd01357
656519002615	active sites [active]
656519002616	tetramer interface [polypeptide binding]; other site
656519002617	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
656519002618	Probable transposase; Region: OrfB_IS605; pfam01385
656519002619	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
656519002620	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
656519002621	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
656519002622	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
656519002623	active site residue [active]
656519002624	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
656519002625	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
656519002626	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
656519002627	ligand binding site [chemical binding]; other site
656519002628	flexible hinge region; other site
656519002629	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
656519002630	putative switch regulator; other site
656519002631	non-specific DNA interactions [nucleotide binding]; other site
656519002632	DNA binding site [nucleotide binding]
656519002633	sequence specific DNA binding site [nucleotide binding]; other site
656519002634	putative cAMP binding site [chemical binding]; other site
656519002635	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
656519002636	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
656519002637	Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378
656519002638	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
656519002639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519002640	Walker A/P-loop; other site
656519002641	ATP binding site [chemical binding]; other site
656519002642	Q-loop/lid; other site
656519002643	ABC transporter signature motif; other site
656519002644	Walker B; other site
656519002645	D-loop; other site
656519002646	H-loop/switch region; other site
656519002647	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
656519002648	DAK2 domain; Region: Dak2; pfam02734
656519002649	EDD domain protein, DegV family; Region: DegV; TIGR00762
656519002650	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
656519002651	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
656519002652	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519002653	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
656519002654	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
656519002655	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
656519002656	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
656519002657	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
656519002658	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
656519002659	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
656519002660	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
656519002661	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
656519002662	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
656519002663	Transcriptional regulators [Transcription]; Region: MarR; COG1846
656519002664	MarR family; Region: MarR_2; pfam12802
656519002665	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
656519002666	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
656519002667	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
656519002668	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
656519002669	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519002670	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
656519002671	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
656519002672	dimer interface [polypeptide binding]; other site
656519002673	active site
656519002674	glycine-pyridoxal phosphate binding site [chemical binding]; other site
656519002675	folate binding site [chemical binding]; other site
656519002676	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519002677	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
656519002678	active site
656519002679	motif I; other site
656519002680	motif II; other site
656519002681	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519002682	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
656519002683	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
656519002684	nucleotide binding site [chemical binding]; other site
656519002685	HPr kinase/phosphorylase; Provisional; Region: PRK05428
656519002686	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
656519002687	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
656519002688	Hpr binding site; other site
656519002689	active site
656519002690	homohexamer subunit interaction site [polypeptide binding]; other site
656519002691	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
656519002692	putative ligand binding site [chemical binding]; other site
656519002693	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
656519002694	substrate binding pocket [chemical binding]; other site
656519002695	substrate-Mg2+ binding site; other site
656519002696	aspartate-rich region 1; other site
656519002697	aspartate-rich region 2; other site
656519002698	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
656519002699	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
656519002700	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
656519002701	phosphate binding site [ion binding]; other site
656519002702	putative substrate binding pocket [chemical binding]; other site
656519002703	dimer interface [polypeptide binding]; other site
656519002704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
656519002705	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
656519002706	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
656519002707	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
656519002708	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
656519002709	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
656519002710	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
656519002711	Phosphoglycerate kinase; Region: PGK; pfam00162
656519002712	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
656519002713	substrate binding site [chemical binding]; other site
656519002714	hinge regions; other site
656519002715	ADP binding site [chemical binding]; other site
656519002716	catalytic site [active]
656519002717	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
656519002718	triosephosphate isomerase; Provisional; Region: PRK14565
656519002719	substrate binding site [chemical binding]; other site
656519002720	dimer interface [polypeptide binding]; other site
656519002721	catalytic triad [active]
656519002722	phosphoglyceromutase; Provisional; Region: PRK05434
656519002723	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
656519002724	enolase; Provisional; Region: eno; PRK00077
656519002725	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
656519002726	dimer interface [polypeptide binding]; other site
656519002727	metal binding site [ion binding]; metal-binding site
656519002728	substrate binding pocket [chemical binding]; other site
656519002729	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
656519002730	GAF domain; Region: GAF; pfam01590
656519002731	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519002732	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519002733	Zn2+ binding site [ion binding]; other site
656519002734	Mg2+ binding site [ion binding]; other site
656519002735	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519002736	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
656519002737	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519002738	MULE transposase domain; Region: MULE; pfam10551
656519002739	Transposase; Region: DDE_Tnp_ISL3; pfam01610
656519002740	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
656519002741	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
656519002742	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
656519002743	HlyD family secretion protein; Region: HlyD_3; pfam13437
656519002744	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
656519002745	Preprotein translocase SecG subunit; Region: SecG; pfam03840
656519002746	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
656519002747	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
656519002748	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
656519002749	CoenzymeA binding site [chemical binding]; other site
656519002750	subunit interaction site [polypeptide binding]; other site
656519002751	PHB binding site; other site
656519002752	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519002753	Zn2+ binding site [ion binding]; other site
656519002754	Mg2+ binding site [ion binding]; other site
656519002755	ribonuclease R; Region: RNase_R; TIGR02063
656519002756	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
656519002757	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519002758	RNB domain; Region: RNB; pfam00773
656519002759	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
656519002760	RNA binding site [nucleotide binding]; other site
656519002761	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
656519002762	SmpB-tmRNA interface; other site
656519002763	PAS fold; Region: PAS; pfam00989
656519002764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519002765	putative active site [active]
656519002766	heme pocket [chemical binding]; other site
656519002767	PAS domain; Region: PAS_9; pfam13426
656519002768	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519002769	putative active site [active]
656519002770	heme pocket [chemical binding]; other site
656519002771	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519002772	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519002773	metal binding site [ion binding]; metal-binding site
656519002774	active site
656519002775	I-site; other site
656519002776	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519002777	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519002778	Zn2+ binding site [ion binding]; other site
656519002779	Mg2+ binding site [ion binding]; other site
656519002780	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
656519002781	Mechanosensitive ion channel; Region: MS_channel; pfam00924
656519002782	Protein of unknown function (DUF503); Region: DUF503; pfam04456
656519002783	Chromate transporter; Region: Chromate_transp; pfam02417
656519002784	Chromate transporter; Region: Chromate_transp; pfam02417
656519002785	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
656519002786	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
656519002787	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
656519002788	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
656519002789	Walker A/P-loop; other site
656519002790	ATP binding site [chemical binding]; other site
656519002791	Q-loop/lid; other site
656519002792	ABC transporter signature motif; other site
656519002793	Walker B; other site
656519002794	D-loop; other site
656519002795	H-loop/switch region; other site
656519002796	PAS domain; Region: PAS_9; pfam13426
656519002797	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
656519002798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519002799	putative active site [active]
656519002800	heme pocket [chemical binding]; other site
656519002801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519002802	dimer interface [polypeptide binding]; other site
656519002803	phosphorylation site [posttranslational modification]
656519002804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519002805	ATP binding site [chemical binding]; other site
656519002806	Mg2+ binding site [ion binding]; other site
656519002807	G-X-G motif; other site
656519002808	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
656519002809	AMIN domain; Region: AMIN; pfam11741
656519002810	AMIN domain; Region: AMIN; pfam11741
656519002811	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
656519002812	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
656519002813	active site
656519002814	metal binding site [ion binding]; metal-binding site
656519002815	Sporulation and spore germination; Region: Germane; pfam10646
656519002816	glutamate racemase; Provisional; Region: PRK00865
656519002817	ribonuclease PH; Reviewed; Region: rph; PRK00173
656519002818	Ribonuclease PH; Region: RNase_PH_bact; cd11362
656519002819	hexamer interface [polypeptide binding]; other site
656519002820	active site
656519002821	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
656519002822	active site
656519002823	dimerization interface [polypeptide binding]; other site
656519002824	YibE/F-like protein; Region: YibE_F; pfam07907
656519002825	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519002826	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519002827	metal binding site [ion binding]; metal-binding site
656519002828	active site
656519002829	I-site; other site
656519002830	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
656519002831	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519002832	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
656519002833	trigger factor; Provisional; Region: tig; PRK01490
656519002834	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
656519002835	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
656519002836	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
656519002837	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
656519002838	oligomer interface [polypeptide binding]; other site
656519002839	active site residues [active]
656519002840	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
656519002841	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
656519002842	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002843	Walker A motif; other site
656519002844	ATP binding site [chemical binding]; other site
656519002845	Walker B motif; other site
656519002846	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
656519002847	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
656519002848	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002849	Walker A motif; other site
656519002850	ATP binding site [chemical binding]; other site
656519002851	Walker B motif; other site
656519002852	arginine finger; other site
656519002853	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
656519002854	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
656519002855	G1 box; other site
656519002856	GTP/Mg2+ binding site [chemical binding]; other site
656519002857	Switch I region; other site
656519002858	G2 box; other site
656519002859	G3 box; other site
656519002860	Switch II region; other site
656519002861	G4 box; other site
656519002862	G5 box; other site
656519002863	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
656519002864	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519002865	S-adenosylmethionine binding site [chemical binding]; other site
656519002866	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
656519002867	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519002868	Predicted membrane protein [Function unknown]; Region: COG2259
656519002869	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
656519002870	ApbE family; Region: ApbE; pfam02424
656519002871	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
656519002872	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
656519002873	substrate binding pocket [chemical binding]; other site
656519002874	chain length determination region; other site
656519002875	substrate-Mg2+ binding site; other site
656519002876	catalytic residues [active]
656519002877	aspartate-rich region 1; other site
656519002878	active site lid residues [active]
656519002879	aspartate-rich region 2; other site
656519002880	peroxiredoxin; Provisional; Region: PRK13189
656519002881	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
656519002882	dimer interface [polypeptide binding]; other site
656519002883	decamer (pentamer of dimers) interface [polypeptide binding]; other site
656519002884	catalytic triad [active]
656519002885	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
656519002886	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
656519002887	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
656519002888	Histidine kinase; Region: His_kinase; pfam06580
656519002889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519002890	ATP binding site [chemical binding]; other site
656519002891	Mg2+ binding site [ion binding]; other site
656519002892	G-X-G motif; other site
656519002893	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
656519002894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519002895	active site
656519002896	phosphorylation site [posttranslational modification]
656519002897	intermolecular recognition site; other site
656519002898	dimerization interface [polypeptide binding]; other site
656519002899	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519002900	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519002901	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
656519002902	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
656519002903	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
656519002904	DctM-like transporters; Region: DctM; pfam06808
656519002905	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
656519002906	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
656519002907	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
656519002908	putative NAD(P) binding site [chemical binding]; other site
656519002909	active site
656519002910	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
656519002911	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
656519002912	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
656519002913	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
656519002914	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519002915	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519002916	DNA-binding site [nucleotide binding]; DNA binding site
656519002917	FCD domain; Region: FCD; pfam07729
656519002918	Transcriptional regulators [Transcription]; Region: GntR; COG1802
656519002919	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519002920	DNA-binding site [nucleotide binding]; DNA binding site
656519002921	FCD domain; Region: FCD; pfam07729
656519002922	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519002923	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
656519002924	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002925	dimer interface [polypeptide binding]; other site
656519002926	conserved gate region; other site
656519002927	putative PBP binding loops; other site
656519002928	ABC-ATPase subunit interface; other site
656519002929	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
656519002930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519002931	dimer interface [polypeptide binding]; other site
656519002932	conserved gate region; other site
656519002933	putative PBP binding loops; other site
656519002934	ABC-ATPase subunit interface; other site
656519002935	mannonate dehydratase; Provisional; Region: PRK03906
656519002936	mannonate dehydratase; Region: uxuA; TIGR00695
656519002937	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
656519002938	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
656519002939	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
656519002940	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
656519002941	active site
656519002942	catalytic residues [active]
656519002943	altronate oxidoreductase; Provisional; Region: PRK03643
656519002944	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
656519002945	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
656519002946	glucuronate isomerase; Reviewed; Region: PRK02925
656519002947	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
656519002948	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
656519002949	galactarate dehydratase; Region: galactar-dH20; TIGR03248
656519002950	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
656519002951	Predicted permeases [General function prediction only]; Region: COG0679
656519002952	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
656519002953	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
656519002954	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
656519002955	DXD motif; other site
656519002956	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
656519002957	GAF domain; Region: GAF; pfam01590
656519002958	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519002959	putative active site [active]
656519002960	heme pocket [chemical binding]; other site
656519002961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519002962	Walker A motif; other site
656519002963	ATP binding site [chemical binding]; other site
656519002964	Walker B motif; other site
656519002965	arginine finger; other site
656519002966	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
656519002967	DNA-binding interface [nucleotide binding]; DNA binding site
656519002968	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
656519002969	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
656519002970	tetramer interface [polypeptide binding]; other site
656519002971	TPP-binding site [chemical binding]; other site
656519002972	heterodimer interface [polypeptide binding]; other site
656519002973	phosphorylation loop region [posttranslational modification]
656519002974	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
656519002975	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
656519002976	alpha subunit interface [polypeptide binding]; other site
656519002977	TPP binding site [chemical binding]; other site
656519002978	heterodimer interface [polypeptide binding]; other site
656519002979	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519002980	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
656519002981	Methyltransferase domain; Region: Methyltransf_31; pfam13847
656519002982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519002983	S-adenosylmethionine binding site [chemical binding]; other site
656519002984	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
656519002985	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
656519002986	E3 interaction surface; other site
656519002987	lipoyl attachment site [posttranslational modification]; other site
656519002988	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
656519002989	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
656519002990	dimer interface [polypeptide binding]; other site
656519002991	substrate binding site [chemical binding]; other site
656519002992	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
656519002993	dimer interface [polypeptide binding]; other site
656519002994	substrate binding site [chemical binding]; other site
656519002995	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
656519002996	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
656519002997	putative NAD(P) binding site [chemical binding]; other site
656519002998	catalytic Zn binding site [ion binding]; other site
656519002999	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
656519003000	classical (c) SDRs; Region: SDR_c; cd05233
656519003001	NAD(P) binding site [chemical binding]; other site
656519003002	active site
656519003003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
656519003004	Coenzyme A binding pocket [chemical binding]; other site
656519003005	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
656519003006	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
656519003007	active site
656519003008	dimerization interface [polypeptide binding]; other site
656519003009	Methyltransferase domain; Region: Methyltransf_31; pfam13847
656519003010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519003011	S-adenosylmethionine binding site [chemical binding]; other site
656519003012	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
656519003013	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519003014	putative substrate translocation pore; other site
656519003015	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
656519003016	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
656519003017	active site
656519003018	metal binding site [ion binding]; metal-binding site
656519003019	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
656519003020	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519003021	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
656519003022	Walker A motif; other site
656519003023	ATP binding site [chemical binding]; other site
656519003024	Walker B motif; other site
656519003025	arginine finger; other site
656519003026	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
656519003027	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
656519003028	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
656519003029	active site
656519003030	Archaeal flavoproteins [Energy production and conversion]; Region: COG1036
656519003031	Flavoprotein; Region: Flavoprotein; pfam02441
656519003032	dihydropteroate synthase-related protein; Region: TIGR00284
656519003033	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
656519003034	substrate binding pocket [chemical binding]; other site
656519003035	dimer interface [polypeptide binding]; other site
656519003036	inhibitor binding site; inhibition site
656519003037	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
656519003038	Protein of unknown function (DUF447); Region: DUF447; cl17801
656519003039	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
656519003040	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
656519003041	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
656519003042	Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034
656519003043	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
656519003044	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
656519003045	NADP binding site [chemical binding]; other site
656519003046	Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232
656519003047	ATP-grasp domain; Region: ATP-grasp_4; cl17255
656519003048	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
656519003049	molybdopterin cofactor binding site; other site
656519003050	The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761
656519003051	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
656519003052	putative [4Fe-4S] binding site [ion binding]; other site
656519003053	putative molybdopterin cofactor binding site [chemical binding]; other site
656519003054	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
656519003055	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519003056	active site
656519003057	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
656519003058	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
656519003059	FTR, proximal lobe; Region: FTR_C; pfam02741
656519003060	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
656519003061	domain_subunit interface; other site
656519003062	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
656519003063	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
656519003064	trimer interface I [polypeptide binding]; other site
656519003065	putative substrate binding pocket [chemical binding]; other site
656519003066	trimer interface II [polypeptide binding]; other site
656519003067	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
656519003068	ATP-grasp domain; Region: ATP-grasp_4; cl17255
656519003069	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
656519003070	Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642
656519003071	hypothetical protein; Provisional; Region: PRK02227
656519003072	Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668
656519003073	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
656519003074	nucleotide binding site [chemical binding]; other site
656519003075	substrate binding site [chemical binding]; other site
656519003076	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
656519003077	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
656519003078	dihydropteroate synthase; Region: DHPS; TIGR01496
656519003079	substrate binding pocket [chemical binding]; other site
656519003080	dimer interface [polypeptide binding]; other site
656519003081	inhibitor binding site; inhibition site
656519003082	Dihydroneopterin aldolase; Region: FolB; pfam02152
656519003083	active site
656519003084	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
656519003085	catalytic center binding site [active]
656519003086	ATP binding site [chemical binding]; other site
656519003087	ATP-grasp domain; Region: ATP-grasp_4; cl17255
656519003088	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
656519003089	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
656519003090	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
656519003091	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
656519003092	homodimer interface [polypeptide binding]; other site
656519003093	substrate-cofactor binding pocket; other site
656519003094	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519003095	catalytic residue [active]
656519003096	Homoserine O-succinyltransferase; Region: HTS; pfam04204
656519003097	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
656519003098	proposed active site lysine [active]
656519003099	conserved cys residue [active]
656519003100	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
656519003101	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
656519003102	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
656519003103	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
656519003104	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
656519003105	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
656519003106	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
656519003107	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
656519003108	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
656519003109	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
656519003110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519003111	dimer interface [polypeptide binding]; other site
656519003112	conserved gate region; other site
656519003113	putative PBP binding loops; other site
656519003114	ABC-ATPase subunit interface; other site
656519003115	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519003116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519003117	dimer interface [polypeptide binding]; other site
656519003118	conserved gate region; other site
656519003119	putative PBP binding loops; other site
656519003120	ABC-ATPase subunit interface; other site
656519003121	Predicted transcriptional regulator [Transcription]; Region: COG2378
656519003122	HTH domain; Region: HTH_11; pfam08279
656519003123	WYL domain; Region: WYL; pfam13280
656519003124	Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187
656519003125	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
656519003126	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
656519003127	active site
656519003128	substrate binding site [chemical binding]; other site
656519003129	metal binding site [ion binding]; metal-binding site
656519003130	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519003131	FMN binding site [chemical binding]; other site
656519003132	dimer interface [polypeptide binding]; other site
656519003133	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519003134	dimer interface [polypeptide binding]; other site
656519003135	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
656519003136	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
656519003137	active site
656519003138	catalytic tetrad [active]
656519003139	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519003140	putative lipid kinase; Reviewed; Region: PRK13059
656519003141	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
656519003142	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519003143	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
656519003144	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
656519003145	YKOF-related Family; Region: Ykof; pfam07615
656519003146	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
656519003147	Peptidase family M50; Region: Peptidase_M50; pfam02163
656519003148	active site
656519003149	putative substrate binding region [chemical binding]; other site
656519003150	FOG: CBS domain [General function prediction only]; Region: COG0517
656519003151	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
656519003152	Sensory domain found in PocR; Region: PocR; pfam10114
656519003153	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
656519003154	Histidine kinase; Region: His_kinase; pfam06580
656519003155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519003156	ATP binding site [chemical binding]; other site
656519003157	Mg2+ binding site [ion binding]; other site
656519003158	G-X-G motif; other site
656519003159	Response regulator receiver domain; Region: Response_reg; pfam00072
656519003160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519003161	active site
656519003162	phosphorylation site [posttranslational modification]
656519003163	intermolecular recognition site; other site
656519003164	dimerization interface [polypeptide binding]; other site
656519003165	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
656519003166	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519003167	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
656519003168	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
656519003169	Hexamer interface [polypeptide binding]; other site
656519003170	Hexagonal pore residue; other site
656519003171	propanediol utilization protein PduB; Provisional; Region: PRK15415
656519003172	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
656519003173	putative hexamer interface [polypeptide binding]; other site
656519003174	putative hexagonal pore; other site
656519003175	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
656519003176	putative hexamer interface [polypeptide binding]; other site
656519003177	putative hexagonal pore; other site
656519003178	propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444
656519003179	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
656519003180	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
656519003181	alpha-beta subunit interface [polypeptide binding]; other site
656519003182	alpha-gamma subunit interface [polypeptide binding]; other site
656519003183	active site
656519003184	substrate and K+ binding site; other site
656519003185	K+ binding site [ion binding]; other site
656519003186	cobalamin binding site [chemical binding]; other site
656519003187	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
656519003188	propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443
656519003189	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
656519003190	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
656519003191	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
656519003192	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
656519003193	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
656519003194	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
656519003195	Hexamer interface [polypeptide binding]; other site
656519003196	Hexagonal pore residue; other site
656519003197	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
656519003198	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
656519003199	Hexamer interface [polypeptide binding]; other site
656519003200	Hexagonal pore residue; other site
656519003201	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
656519003202	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
656519003203	nucleotide binding site [chemical binding]; other site
656519003204	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
656519003205	nucleotide binding site [chemical binding]; other site
656519003206	Flavoprotein; Region: Flavoprotein; cl08021
656519003207	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
656519003208	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
656519003209	Hexamer/Pentamer interface [polypeptide binding]; other site
656519003210	central pore; other site
656519003211	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
656519003212	Domain of unknown function (DUF336); Region: DUF336; pfam03928
656519003213	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
656519003214	putative catalytic cysteine [active]
656519003215	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
656519003216	SLBB domain; Region: SLBB; pfam10531
656519003217	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519003218	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
656519003219	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
656519003220	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
656519003221	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
656519003222	putative hexamer interface [polypeptide binding]; other site
656519003223	putative hexagonal pore; other site
656519003224	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
656519003225	putative hexamer interface [polypeptide binding]; other site
656519003226	putative hexagonal pore; other site
656519003227	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519003228	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
656519003229	active site
656519003230	NAD binding site [chemical binding]; other site
656519003231	metal binding site [ion binding]; metal-binding site
656519003232	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
656519003233	propionate/acetate kinase; Provisional; Region: PRK12379
656519003234	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
656519003235	putative hexamer interface [polypeptide binding]; other site
656519003236	putative hexagonal pore; other site
656519003237	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
656519003238	G1 box; other site
656519003239	GTP/Mg2+ binding site [chemical binding]; other site
656519003240	Switch I region; other site
656519003241	G3 box; other site
656519003242	Switch II region; other site
656519003243	G4 box; other site
656519003244	G5 box; other site
656519003245	Predicted kinase [General function prediction only]; Region: COG4857; cl17281
656519003246	Phosphotransferase enzyme family; Region: APH; pfam01636
656519003247	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
656519003248	Propanediol utilisation protein PduL; Region: PduL; pfam06130
656519003249	Propanediol utilisation protein PduL; Region: PduL; pfam06130
656519003250	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
656519003251	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
656519003252	dimer interface [polypeptide binding]; other site
656519003253	Domain of unknown function (DUF389); Region: DUF389; cl00781
656519003254	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
656519003255	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
656519003256	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519003257	FeS/SAM binding site; other site
656519003258	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
656519003259	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
656519003260	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
656519003261	NodB motif; other site
656519003262	active site
656519003263	catalytic site [active]
656519003264	metal binding site [ion binding]; metal-binding site
656519003265	Protein of unknown function DUF89; Region: DUF89; cl15397
656519003266	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
656519003267	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
656519003268	B12 binding site [chemical binding]; other site
656519003269	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
656519003270	Sensory domain found in PocR; Region: PocR; pfam10114
656519003271	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519003272	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
656519003273	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519003274	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
656519003275	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
656519003276	N- and C-terminal domain interface [polypeptide binding]; other site
656519003277	putative active site [active]
656519003278	MgATP binding site [chemical binding]; other site
656519003279	catalytic site [active]
656519003280	metal binding site [ion binding]; metal-binding site
656519003281	putative xylulose binding site [chemical binding]; other site
656519003282	putative homodimer interface [polypeptide binding]; other site
656519003283	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
656519003284	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
656519003285	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
656519003286	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
656519003287	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
656519003288	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519003289	Transposase; Region: HTH_Tnp_1; pfam01527
656519003290	putative transposase OrfB; Reviewed; Region: PHA02517
656519003291	HTH-like domain; Region: HTH_21; pfam13276
656519003292	Integrase core domain; Region: rve; pfam00665
656519003293	Integrase core domain; Region: rve_3; pfam13683
656519003294	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519003295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
656519003296	Domain of unknown function DUF20; Region: UPF0118; pfam01594
656519003297	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
656519003298	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519003299	MULE transposase domain; Region: MULE; pfam10551
656519003300	Transposase; Region: DDE_Tnp_ISL3; pfam01610
656519003301	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
656519003302	transposase; Provisional; Region: PRK06526
656519003303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519003304	Walker A motif; other site
656519003305	ATP binding site [chemical binding]; other site
656519003306	Walker B motif; other site
656519003307	Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417
656519003308	YvrJ protein family; Region: YvrJ; pfam12841
656519003309	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519003310	Transposase; Region: HTH_Tnp_1; pfam01527
656519003311	HTH-like domain; Region: HTH_21; pfam13276
656519003312	Integrase core domain; Region: rve; pfam00665
656519003313	Integrase core domain; Region: rve_3; pfam13683
656519003314	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
656519003315	Uncharacterized conserved protein [Function unknown]; Region: COG3472
656519003316	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
656519003317	DNA methylase; Region: N6_N4_Mtase; pfam01555
656519003318	DNA methylase; Region: N6_N4_Mtase; pfam01555
656519003319	DEAD-like helicases superfamily; Region: DEXDc; smart00487
656519003320	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
656519003321	Family description; Region: UvrD_C_2; pfam13538
656519003322	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
656519003323	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519003324	MULE transposase domain; Region: MULE; pfam10551
656519003325	Transposase; Region: DDE_Tnp_ISL3; pfam01610
656519003326	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
656519003327	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
656519003328	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519003329	dimerization interface [polypeptide binding]; other site
656519003330	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519003331	putative active site [active]
656519003332	heme pocket [chemical binding]; other site
656519003333	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519003334	dimer interface [polypeptide binding]; other site
656519003335	phosphorylation site [posttranslational modification]
656519003336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519003337	ATP binding site [chemical binding]; other site
656519003338	Mg2+ binding site [ion binding]; other site
656519003339	G-X-G motif; other site
656519003340	Response regulator receiver domain; Region: Response_reg; pfam00072
656519003341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519003342	active site
656519003343	phosphorylation site [posttranslational modification]
656519003344	intermolecular recognition site; other site
656519003345	dimerization interface [polypeptide binding]; other site
656519003346	Response regulator receiver domain; Region: Response_reg; pfam00072
656519003347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519003348	active site
656519003349	phosphorylation site [posttranslational modification]
656519003350	intermolecular recognition site; other site
656519003351	dimerization interface [polypeptide binding]; other site
656519003352	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519003353	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519003354	TPR motif; other site
656519003355	binding surface
656519003356	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
656519003357	TrkA-N domain; Region: TrkA_N; pfam02254
656519003358	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
656519003359	TrkA-N domain; Region: TrkA_N; pfam02254
656519003360	TrkA-C domain; Region: TrkA_C; pfam02080
656519003361	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
656519003362	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
656519003363	Sulphur transport; Region: Sulf_transp; pfam04143
656519003364	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
656519003365	transmembrane helices; other site
656519003366	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
656519003367	TrkA-C domain; Region: TrkA_C; pfam02080
656519003368	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
656519003369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519003370	Response regulator receiver domain; Region: Response_reg; pfam00072
656519003371	active site
656519003372	phosphorylation site [posttranslational modification]
656519003373	intermolecular recognition site; other site
656519003374	dimerization interface [polypeptide binding]; other site
656519003375	PAS domain; Region: PAS_9; pfam13426
656519003376	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519003377	PAS fold; Region: PAS_3; pfam08447
656519003378	putative active site [active]
656519003379	heme pocket [chemical binding]; other site
656519003380	GAF domain; Region: GAF_3; pfam13492
656519003381	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519003382	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519003383	metal binding site [ion binding]; metal-binding site
656519003384	active site
656519003385	I-site; other site
656519003386	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519003387	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519003388	Zn2+ binding site [ion binding]; other site
656519003389	Mg2+ binding site [ion binding]; other site
656519003390	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519003391	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
656519003392	putative active site [active]
656519003393	heme pocket [chemical binding]; other site
656519003394	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519003395	putative active site [active]
656519003396	heme pocket [chemical binding]; other site
656519003397	PAS domain S-box; Region: sensory_box; TIGR00229
656519003398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519003399	putative active site [active]
656519003400	heme pocket [chemical binding]; other site
656519003401	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519003402	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519003403	metal binding site [ion binding]; metal-binding site
656519003404	active site
656519003405	I-site; other site
656519003406	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519003407	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519003408	Zn2+ binding site [ion binding]; other site
656519003409	Mg2+ binding site [ion binding]; other site
656519003410	circadian clock protein KaiC; Reviewed; Region: PRK09302
656519003411	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
656519003412	ATP binding site [chemical binding]; other site
656519003413	Walker B motif; other site
656519003414	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
656519003415	ATP binding site [chemical binding]; other site
656519003416	Walker B motif; other site
656519003417	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519003418	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519003419	metal binding site [ion binding]; metal-binding site
656519003420	active site
656519003421	I-site; other site
656519003422	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519003423	Zn2+ binding site [ion binding]; other site
656519003424	Mg2+ binding site [ion binding]; other site
656519003425	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
656519003426	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
656519003427	ligand binding site; other site
656519003428	oligomer interface; other site
656519003429	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
656519003430	dimer interface [polypeptide binding]; other site
656519003431	N-terminal domain interface [polypeptide binding]; other site
656519003432	sulfate 1 binding site; other site
656519003433	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
656519003434	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
656519003435	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
656519003436	Transposase; Region: HTH_Tnp_1; pfam01527
656519003437	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519003438	putative transposase OrfB; Reviewed; Region: PHA02517
656519003439	HTH-like domain; Region: HTH_21; pfam13276
656519003440	Integrase core domain; Region: rve; pfam00665
656519003441	Integrase core domain; Region: rve_3; pfam13683
656519003442	beta-D-glucuronidase; Provisional; Region: PRK10150
656519003443	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
656519003444	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
656519003445	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
656519003446	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
656519003447	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
656519003448	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
656519003449	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
656519003450	active site
656519003451	catalytic site [active]
656519003452	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
656519003453	Active site flap [active]
656519003454	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519003455	Zn2+ binding site [ion binding]; other site
656519003456	Mg2+ binding site [ion binding]; other site
656519003457	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
656519003458	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
656519003459	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
656519003460	tetramer (dimer of dimers) interface [polypeptide binding]; other site
656519003461	active site
656519003462	dimer interface [polypeptide binding]; other site
656519003463	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
656519003464	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
656519003465	C-terminal domain interface [polypeptide binding]; other site
656519003466	GSH binding site (G-site) [chemical binding]; other site
656519003467	dimer interface [polypeptide binding]; other site
656519003468	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
656519003469	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
656519003470	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
656519003471	Peptidase family M23; Region: Peptidase_M23; pfam01551
656519003472	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
656519003473	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
656519003474	metal-binding site [ion binding]
656519003475	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
656519003476	Soluble P-type ATPase [General function prediction only]; Region: COG4087
656519003477	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519003478	dimerization interface [polypeptide binding]; other site
656519003479	putative DNA binding site [nucleotide binding]; other site
656519003480	putative Zn2+ binding site [ion binding]; other site
656519003481	Methyltransferase domain; Region: Methyltransf_31; pfam13847
656519003482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519003483	S-adenosylmethionine binding site [chemical binding]; other site
656519003484	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
656519003485	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
656519003486	GTP binding site; other site
656519003487	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
656519003488	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
656519003489	active site
656519003490	HIGH motif; other site
656519003491	nucleotide binding site [chemical binding]; other site
656519003492	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
656519003493	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
656519003494	active site
656519003495	KMSKS motif; other site
656519003496	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
656519003497	tRNA binding surface [nucleotide binding]; other site
656519003498	anticodon binding site; other site
656519003499	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
656519003500	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
656519003501	transmembrane helices; other site
656519003502	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
656519003503	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
656519003504	dimer interface [polypeptide binding]; other site
656519003505	putative functional site; other site
656519003506	putative MPT binding site; other site
656519003507	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
656519003508	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
656519003509	dimer interface [polypeptide binding]; other site
656519003510	putative functional site; other site
656519003511	putative MPT binding site; other site
656519003512	PBP superfamily domain; Region: PBP_like; pfam12727
656519003513	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
656519003514	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519003515	FeS/SAM binding site; other site
656519003516	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
656519003517	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
656519003518	trimer interface [polypeptide binding]; other site
656519003519	dimer interface [polypeptide binding]; other site
656519003520	putative active site [active]
656519003521	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
656519003522	MPT binding site; other site
656519003523	trimer interface [polypeptide binding]; other site
656519003524	MOSC domain; Region: MOSC; pfam03473
656519003525	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
656519003526	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
656519003527	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
656519003528	dimer interface [polypeptide binding]; other site
656519003529	active site
656519003530	CoA binding pocket [chemical binding]; other site
656519003531	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
656519003532	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
656519003533	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
656519003534	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
656519003535	dimer interface [polypeptide binding]; other site
656519003536	active site
656519003537	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639
656519003538	Asp23 family; Region: Asp23; pfam03780
656519003539	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
656519003540	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
656519003541	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
656519003542	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
656519003543	EamA-like transporter family; Region: EamA; pfam00892
656519003544	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
656519003545	EamA-like transporter family; Region: EamA; pfam00892
656519003546	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
656519003547	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
656519003548	TPP-binding site [chemical binding]; other site
656519003549	dimer interface [polypeptide binding]; other site
656519003550	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
656519003551	PYR/PP interface [polypeptide binding]; other site
656519003552	dimer interface [polypeptide binding]; other site
656519003553	TPP binding site [chemical binding]; other site
656519003554	Divergent PAP2 family; Region: DUF212; pfam02681
656519003555	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
656519003556	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519003557	Sporulation related domain; Region: SPOR; pfam05036
656519003558	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
656519003559	SLBB domain; Region: SLBB; pfam10531
656519003560	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519003561	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
656519003562	FMN-binding domain; Region: FMN_bind; cl01081
656519003563	electron transport complex RsxE subunit; Provisional; Region: PRK12405
656519003564	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
656519003565	ferredoxin; Provisional; Region: PRK08764
656519003566	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519003567	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
656519003568	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519003569	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
656519003570	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
656519003571	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
656519003572	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519003573	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
656519003574	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
656519003575	putative active site [active]
656519003576	putative NTP binding site [chemical binding]; other site
656519003577	putative nucleic acid binding site [nucleotide binding]; other site
656519003578	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
656519003579	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
656519003580	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
656519003581	Maf-like protein; Region: Maf; pfam02545
656519003582	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
656519003583	active site
656519003584	dimer interface [polypeptide binding]; other site
656519003585	hypothetical protein; Reviewed; Region: PRK00024
656519003586	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
656519003587	MPN+ (JAMM) motif; other site
656519003588	Zinc-binding site [ion binding]; other site
656519003589	rod shape-determining protein MreB; Provisional; Region: PRK13927
656519003590	MreB and similar proteins; Region: MreB_like; cd10225
656519003591	nucleotide binding site [chemical binding]; other site
656519003592	Mg binding site [ion binding]; other site
656519003593	putative protofilament interaction site [polypeptide binding]; other site
656519003594	RodZ interaction site [polypeptide binding]; other site
656519003595	rod shape-determining protein MreC; Provisional; Region: PRK13922
656519003596	rod shape-determining protein MreC; Region: MreC; pfam04085
656519003597	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
656519003598	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
656519003599	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
656519003600	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
656519003601	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
656519003602	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
656519003603	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
656519003604	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
656519003605	Switch I; other site
656519003606	Switch II; other site
656519003607	Septum formation topological specificity factor MinE; Region: MinE; pfam03776
656519003608	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
656519003609	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
656519003610	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519003611	FeS/SAM binding site; other site
656519003612	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
656519003613	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
656519003614	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
656519003615	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
656519003616	homodimer interface [polypeptide binding]; other site
656519003617	oligonucleotide binding site [chemical binding]; other site
656519003618	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
656519003619	nucleic acid binding region [nucleotide binding]; other site
656519003620	G-X-X-G motif; other site
656519003621	TRAM domain; Region: TRAM; cl01282
656519003622	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
656519003623	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
656519003624	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
656519003625	GTPase CgtA; Reviewed; Region: obgE; PRK12297
656519003626	GTP1/OBG; Region: GTP1_OBG; pfam01018
656519003627	Obg GTPase; Region: Obg; cd01898
656519003628	G1 box; other site
656519003629	GTP/Mg2+ binding site [chemical binding]; other site
656519003630	Switch I region; other site
656519003631	G2 box; other site
656519003632	G3 box; other site
656519003633	Switch II region; other site
656519003634	G4 box; other site
656519003635	G5 box; other site
656519003636	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
656519003637	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
656519003638	EDD domain protein, DegV family; Region: DegV; TIGR00762
656519003639	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
656519003640	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
656519003641	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
656519003642	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
656519003643	ABC transporter; Region: ABC_tran_2; pfam12848
656519003644	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
656519003645	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
656519003646	Nitrogen regulatory protein P-II; Region: P-II; smart00938
656519003647	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
656519003648	NAD synthetase; Provisional; Region: PRK13980
656519003649	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
656519003650	homodimer interface [polypeptide binding]; other site
656519003651	NAD binding pocket [chemical binding]; other site
656519003652	ATP binding pocket [chemical binding]; other site
656519003653	Mg binding site [ion binding]; other site
656519003654	active-site loop [active]
656519003655	glutamine synthetase, type I; Region: GlnA; TIGR00653
656519003656	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
656519003657	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
656519003658	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
656519003659	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
656519003660	PYR/PP interface [polypeptide binding]; other site
656519003661	dimer interface [polypeptide binding]; other site
656519003662	TPP binding site [chemical binding]; other site
656519003663	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
656519003664	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
656519003665	TPP-binding site [chemical binding]; other site
656519003666	dimer interface [polypeptide binding]; other site
656519003667	Sulfatase; Region: Sulfatase; pfam00884
656519003668	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
656519003669	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
656519003670	catalytic motif [active]
656519003671	Zn binding site [ion binding]; other site
656519003672	RibD C-terminal domain; Region: RibD_C; cl17279
656519003673	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
656519003674	Lumazine binding domain; Region: Lum_binding; pfam00677
656519003675	Lumazine binding domain; Region: Lum_binding; pfam00677
656519003676	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
656519003677	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
656519003678	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
656519003679	dimerization interface [polypeptide binding]; other site
656519003680	active site
656519003681	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
656519003682	homopentamer interface [polypeptide binding]; other site
656519003683	active site
656519003684	glycerol kinase; Provisional; Region: glpK; PRK00047
656519003685	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
656519003686	N- and C-terminal domain interface [polypeptide binding]; other site
656519003687	active site
656519003688	MgATP binding site [chemical binding]; other site
656519003689	catalytic site [active]
656519003690	metal binding site [ion binding]; metal-binding site
656519003691	glycerol binding site [chemical binding]; other site
656519003692	homotetramer interface [polypeptide binding]; other site
656519003693	homodimer interface [polypeptide binding]; other site
656519003694	FBP binding site [chemical binding]; other site
656519003695	protein IIAGlc interface [polypeptide binding]; other site
656519003696	Predicted dehydrogenase [General function prediction only]; Region: COG0579
656519003697	hydroxyglutarate oxidase; Provisional; Region: PRK11728
656519003698	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
656519003699	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
656519003700	methionine sulfoxide reductase B; Provisional; Region: PRK00222
656519003701	SelR domain; Region: SelR; pfam01641
656519003702	Predicted permease [General function prediction only]; Region: COG2056
656519003703	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
656519003704	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
656519003705	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
656519003706	active site
656519003707	substrate binding site [chemical binding]; other site
656519003708	metal binding site [ion binding]; metal-binding site
656519003709	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
656519003710	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
656519003711	active site
656519003712	catalytic tetrad [active]
656519003713	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
656519003714	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
656519003715	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
656519003716	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519003717	catalytic residue [active]
656519003718	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
656519003719	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
656519003720	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
656519003721	Uncharacterized conserved protein [Function unknown]; Region: COG1656
656519003722	Protein of unknown function DUF82; Region: DUF82; pfam01927
656519003723	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519003724	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519003725	Integrase core domain; Region: rve; pfam00665
656519003726	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
656519003727	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
656519003728	transmembrane helices; other site
656519003729	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
656519003730	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
656519003731	Coenzyme A binding pocket [chemical binding]; other site
656519003732	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
656519003733	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
656519003734	HTH domain; Region: HTH_11; pfam08279
656519003735	Mga helix-turn-helix domain; Region: Mga; pfam05043
656519003736	PRD domain; Region: PRD; pfam00874
656519003737	PRD domain; Region: PRD; pfam00874
656519003738	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
656519003739	active site
656519003740	P-loop; other site
656519003741	phosphorylation site [posttranslational modification]
656519003742	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
656519003743	active site
656519003744	phosphorylation site [posttranslational modification]
656519003745	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
656519003746	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
656519003747	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
656519003748	active site
656519003749	P-loop; other site
656519003750	phosphorylation site [posttranslational modification]
656519003751	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519003752	active site
656519003753	phosphorylation site [posttranslational modification]
656519003754	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
656519003755	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
656519003756	putative substrate binding site [chemical binding]; other site
656519003757	putative ATP binding site [chemical binding]; other site
656519003758	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
656519003759	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
656519003760	putative NAD(P) binding site [chemical binding]; other site
656519003761	catalytic Zn binding site [ion binding]; other site
656519003762	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519003763	dimerization domain swap beta strand [polypeptide binding]; other site
656519003764	regulatory protein interface [polypeptide binding]; other site
656519003765	active site
656519003766	regulatory phosphorylation site [posttranslational modification]; other site
656519003767	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
656519003768	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
656519003769	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
656519003770	putative ADP-ribose binding site [chemical binding]; other site
656519003771	putative active site [active]
656519003772	Putative cyclase; Region: Cyclase; cl00814
656519003773	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
656519003774	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
656519003775	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
656519003776	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519003777	motif II; other site
656519003778	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519003779	D-glutamate deacylase; Validated; Region: PRK09061
656519003780	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519003781	active site
656519003782	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519003783	Predicted membrane protein [Function unknown]; Region: COG1288
656519003784	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
656519003785	Malic enzyme, N-terminal domain; Region: malic; pfam00390
656519003786	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
656519003787	putative NAD(P) binding site [chemical binding]; other site
656519003788	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
656519003789	metal binding triad [ion binding]; metal-binding site
656519003790	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
656519003791	synthetase active site [active]
656519003792	NTP binding site [chemical binding]; other site
656519003793	metal binding site [ion binding]; metal-binding site
656519003794	homoserine dehydrogenase; Provisional; Region: PRK06349
656519003795	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
656519003796	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
656519003797	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
656519003798	Leucine carboxyl methyltransferase; Region: LCM; cl01306
656519003799	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
656519003800	Uncharacterized conserved protein [Function unknown]; Region: COG0398
656519003801	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
656519003802	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
656519003803	Acyltransferase family; Region: Acyl_transf_3; pfam01757
656519003804	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
656519003805	active site residue [active]
656519003806	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
656519003807	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
656519003808	catalytic residues [active]
656519003809	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519003810	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
656519003811	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
656519003812	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
656519003813	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
656519003814	Citrate synthase; Region: Citrate_synt; pfam00285
656519003815	oxalacetate binding site [chemical binding]; other site
656519003816	citrylCoA binding site [chemical binding]; other site
656519003817	coenzyme A binding site [chemical binding]; other site
656519003818	catalytic triad [active]
656519003819	short chain dehydrogenase; Validated; Region: PRK06182
656519003820	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
656519003821	NADP binding site [chemical binding]; other site
656519003822	active site
656519003823	steroid binding site; other site
656519003824	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
656519003825	trimer interface [polypeptide binding]; other site
656519003826	active site
656519003827	G bulge; other site
656519003828	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
656519003829	dimer interface [polypeptide binding]; other site
656519003830	putative tRNA-binding site [nucleotide binding]; other site
656519003831	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
656519003832	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
656519003833	pyruvate carboxylase; Reviewed; Region: PRK12999
656519003834	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519003835	ATP-grasp domain; Region: ATP-grasp_4; cl17255
656519003836	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
656519003837	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
656519003838	active site
656519003839	catalytic residues [active]
656519003840	metal binding site [ion binding]; metal-binding site
656519003841	homodimer binding site [polypeptide binding]; other site
656519003842	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
656519003843	carboxyltransferase (CT) interaction site; other site
656519003844	biotinylation site [posttranslational modification]; other site
656519003845	Predicted membrane protein [Function unknown]; Region: COG4818
656519003846	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
656519003847	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
656519003848	active site
656519003849	metal binding site [ion binding]; metal-binding site
656519003850	DNA binding site [nucleotide binding]
656519003851	Uncharacterized conserved protein [Function unknown]; Region: COG4717
656519003852	AAA domain; Region: AAA_27; pfam13514
656519003853	DNA polymerase IV; Reviewed; Region: PRK03103
656519003854	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
656519003855	active site
656519003856	DNA binding site [nucleotide binding]
656519003857	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
656519003858	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
656519003859	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519003860	active site
656519003861	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
656519003862	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519003863	Walker A motif; other site
656519003864	ATP binding site [chemical binding]; other site
656519003865	Walker B motif; other site
656519003866	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
656519003867	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
656519003868	ATP binding site [chemical binding]; other site
656519003869	Mg++ binding site [ion binding]; other site
656519003870	motif III; other site
656519003871	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519003872	nucleotide binding region [chemical binding]; other site
656519003873	ATP-binding site [chemical binding]; other site
656519003874	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
656519003875	RNA binding site [nucleotide binding]; other site
656519003876	glutamate dehydrogenase; Provisional; Region: PRK09414
656519003877	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
656519003878	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
656519003879	NAD(P) binding site [chemical binding]; other site
656519003880	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
656519003881	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
656519003882	active site
656519003883	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
656519003884	substrate binding site [chemical binding]; other site
656519003885	catalytic residues [active]
656519003886	dimer interface [polypeptide binding]; other site
656519003887	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
656519003888	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
656519003889	dimer interface [polypeptide binding]; other site
656519003890	active site
656519003891	catalytic residue [active]
656519003892	dihydrodipicolinate reductase; Provisional; Region: PRK00048
656519003893	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
656519003894	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
656519003895	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
656519003896	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
656519003897	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
656519003898	trimer interface [polypeptide binding]; other site
656519003899	active site
656519003900	substrate binding site [chemical binding]; other site
656519003901	CoA binding site [chemical binding]; other site
656519003902	acetylornithine aminotransferase; Provisional; Region: PRK02627
656519003903	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519003904	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519003905	catalytic residue [active]
656519003906	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
656519003907	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
656519003908	active site
656519003909	DNA binding site [nucleotide binding]
656519003910	Int/Topo IB signature motif; other site
656519003911	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
656519003912	Clp amino terminal domain; Region: Clp_N; pfam02861
656519003913	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519003914	Walker A motif; other site
656519003915	ATP binding site [chemical binding]; other site
656519003916	Walker B motif; other site
656519003917	arginine finger; other site
656519003918	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519003919	Walker A motif; other site
656519003920	ATP binding site [chemical binding]; other site
656519003921	Walker B motif; other site
656519003922	arginine finger; other site
656519003923	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
656519003924	Phospholipid methyltransferase; Region: PEMT; cl17370
656519003925	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
656519003926	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
656519003927	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
656519003928	putative addiction module antidote; Region: doc_partner; TIGR02609
656519003929	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
656519003930	Fic family protein [Function unknown]; Region: COG3177
656519003931	Fic/DOC family; Region: Fic; pfam02661
656519003932	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519003933	S-adenosylmethionine binding site [chemical binding]; other site
656519003934	Methyltransferase domain; Region: Methyltransf_23; pfam13489
656519003935	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519003936	S-adenosylmethionine binding site [chemical binding]; other site
656519003937	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
656519003938	NADH(P)-binding; Region: NAD_binding_10; pfam13460
656519003939	NAD(P) binding site [chemical binding]; other site
656519003940	putative active site [active]
656519003941	CAAX protease self-immunity; Region: Abi; cl00558
656519003942	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
656519003943	Probable transposase; Region: OrfB_IS605; pfam01385
656519003944	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
656519003945	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
656519003946	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
656519003947	folate binding site [chemical binding]; other site
656519003948	NADP+ binding site [chemical binding]; other site
656519003949	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
656519003950	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
656519003951	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
656519003952	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
656519003953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519003954	catalytic residue [active]
656519003955	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
656519003956	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519003957	DNA-binding site [nucleotide binding]; DNA binding site
656519003958	UTRA domain; Region: UTRA; pfam07702
656519003959	Chromate transporter; Region: Chromate_transp; pfam02417
656519003960	Transposase; Region: HTH_Tnp_1; pfam01527
656519003961	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519003962	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
656519003963	HTH-like domain; Region: HTH_21; pfam13276
656519003964	Integrase core domain; Region: rve; pfam00665
656519003965	Integrase core domain; Region: rve_3; pfam13683
656519003966	Chromate transporter; Region: Chromate_transp; pfam02417
656519003967	Flavin Reductases; Region: FlaRed; cl00801
656519003968	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
656519003969	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
656519003970	catalytic residues [active]
656519003971	catalytic nucleophile [active]
656519003972	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
656519003973	LexA repressor; Validated; Region: PRK00215
656519003974	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
656519003975	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
656519003976	Catalytic site [active]
656519003977	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
656519003978	Fe-S cluster binding site [ion binding]; other site
656519003979	active site
656519003980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
656519003981	TPR motif; other site
656519003982	binding surface
656519003983	bacterial Hfq-like; Region: Hfq; cd01716
656519003984	hexamer interface [polypeptide binding]; other site
656519003985	Sm1 motif; other site
656519003986	RNA binding site [nucleotide binding]; other site
656519003987	Sm2 motif; other site
656519003988	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
656519003989	catalytic residues [active]
656519003990	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
656519003991	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
656519003992	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
656519003993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519003994	ATP binding site [chemical binding]; other site
656519003995	Mg2+ binding site [ion binding]; other site
656519003996	G-X-G motif; other site
656519003997	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
656519003998	ATP binding site [chemical binding]; other site
656519003999	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
656519004000	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
656519004001	MutS domain I; Region: MutS_I; pfam01624
656519004002	MutS domain II; Region: MutS_II; pfam05188
656519004003	MutS domain III; Region: MutS_III; pfam05192
656519004004	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
656519004005	Walker A/P-loop; other site
656519004006	ATP binding site [chemical binding]; other site
656519004007	Q-loop/lid; other site
656519004008	ABC transporter signature motif; other site
656519004009	Walker B; other site
656519004010	D-loop; other site
656519004011	H-loop/switch region; other site
656519004012	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
656519004013	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
656519004014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519004015	FeS/SAM binding site; other site
656519004016	TRAM domain; Region: TRAM; pfam01938
656519004017	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
656519004018	TrkA-N domain; Region: TrkA_N; pfam02254
656519004019	TrkA-C domain; Region: TrkA_C; pfam02080
656519004020	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
656519004021	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
656519004022	Rubredoxin [Energy production and conversion]; Region: COG1773
656519004023	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
656519004024	iron binding site [ion binding]; other site
656519004025	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
656519004026	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
656519004027	Cl- selectivity filter; other site
656519004028	Cl- binding residues [ion binding]; other site
656519004029	pore gating glutamate residue; other site
656519004030	dimer interface [polypeptide binding]; other site
656519004031	FOG: CBS domain [General function prediction only]; Region: COG0517
656519004032	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
656519004033	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
656519004034	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
656519004035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519004036	ATP binding site [chemical binding]; other site
656519004037	Mg2+ binding site [ion binding]; other site
656519004038	G-X-G motif; other site
656519004039	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519004040	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519004041	Integrase core domain; Region: rve; pfam00665
656519004042	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
656519004043	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519004044	Mg2+ binding site [ion binding]; other site
656519004045	G-X-G motif; other site
656519004046	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
656519004047	anchoring element; other site
656519004048	dimer interface [polypeptide binding]; other site
656519004049	ATP binding site [chemical binding]; other site
656519004050	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
656519004051	active site
656519004052	putative metal-binding site [ion binding]; other site
656519004053	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
656519004054	DNA gyrase subunit A; Validated; Region: PRK05560
656519004055	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
656519004056	CAP-like domain; other site
656519004057	active site
656519004058	primary dimer interface [polypeptide binding]; other site
656519004059	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
656519004060	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
656519004061	S-layer homology domain; Region: SLH; pfam00395
656519004062	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
656519004063	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
656519004064	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
656519004065	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
656519004066	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
656519004067	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
656519004068	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519004069	dimerization interface [polypeptide binding]; other site
656519004070	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
656519004071	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519004072	dimer interface [polypeptide binding]; other site
656519004073	phosphorylation site [posttranslational modification]
656519004074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519004075	ATP binding site [chemical binding]; other site
656519004076	Mg2+ binding site [ion binding]; other site
656519004077	G-X-G motif; other site
656519004078	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
656519004079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519004080	active site
656519004081	phosphorylation site [posttranslational modification]
656519004082	intermolecular recognition site; other site
656519004083	dimerization interface [polypeptide binding]; other site
656519004084	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
656519004085	DNA binding site [nucleotide binding]
656519004086	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
656519004087	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
656519004088	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
656519004089	putative active site [active]
656519004090	metal binding site [ion binding]; metal-binding site
656519004091	homodimer binding site [polypeptide binding]; other site
656519004092	phosphodiesterase; Provisional; Region: PRK12704
656519004093	Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669
656519004094	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519004095	Zn2+ binding site [ion binding]; other site
656519004096	Mg2+ binding site [ion binding]; other site
656519004097	RecX family; Region: RecX; pfam02631
656519004098	recombinase A; Provisional; Region: recA; PRK09354
656519004099	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
656519004100	hexamer interface [polypeptide binding]; other site
656519004101	Walker A motif; other site
656519004102	ATP binding site [chemical binding]; other site
656519004103	Walker B motif; other site
656519004104	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
656519004105	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
656519004106	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519004107	TPR motif; other site
656519004108	binding surface
656519004109	TPR repeat; Region: TPR_11; pfam13414
656519004110	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519004111	binding surface
656519004112	TPR repeat; Region: TPR_11; pfam13414
656519004113	TPR motif; other site
656519004114	TPR repeat; Region: TPR_11; pfam13414
656519004115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519004116	binding surface
656519004117	TPR motif; other site
656519004118	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519004119	competence damage-inducible protein A; Provisional; Region: PRK00549
656519004120	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
656519004121	putative MPT binding site; other site
656519004122	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
656519004123	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
656519004124	tetramer interfaces [polypeptide binding]; other site
656519004125	binuclear metal-binding site [ion binding]; other site
656519004126	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
656519004127	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
656519004128	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
656519004129	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519004130	FeS/SAM binding site; other site
656519004131	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
656519004132	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
656519004133	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519004134	Walker A/P-loop; other site
656519004135	ATP binding site [chemical binding]; other site
656519004136	Q-loop/lid; other site
656519004137	ABC transporter signature motif; other site
656519004138	Walker B; other site
656519004139	D-loop; other site
656519004140	H-loop/switch region; other site
656519004141	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
656519004142	ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243
656519004143	Walker A/P-loop; other site
656519004144	ATP binding site [chemical binding]; other site
656519004145	Q-loop/lid; other site
656519004146	ABC transporter signature motif; other site
656519004147	Walker B; other site
656519004148	D-loop; other site
656519004149	H-loop/switch region; other site
656519004150	mercuric reductase; Validated; Region: PRK06370
656519004151	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
656519004152	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519004153	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519004154	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
656519004155	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
656519004156	NAD binding site [chemical binding]; other site
656519004157	dimer interface [polypeptide binding]; other site
656519004158	substrate binding site [chemical binding]; other site
656519004159	tetramer (dimer of dimers) interface [polypeptide binding]; other site
656519004160	Uncharacterized conserved protein [Function unknown]; Region: COG2006
656519004161	Domain of unknown function (DUF362); Region: DUF362; pfam04015
656519004162	Methyltransferase domain; Region: Methyltransf_31; pfam13847
656519004163	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
656519004164	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
656519004165	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
656519004166	Helix-turn-helix domain; Region: HTH_25; pfam13413
656519004167	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
656519004168	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
656519004169	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
656519004170	TM-ABC transporter signature motif; other site
656519004171	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
656519004172	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
656519004173	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
656519004174	TM-ABC transporter signature motif; other site
656519004175	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
656519004176	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519004177	Walker A/P-loop; other site
656519004178	ATP binding site [chemical binding]; other site
656519004179	Q-loop/lid; other site
656519004180	ABC transporter signature motif; other site
656519004181	Walker B; other site
656519004182	D-loop; other site
656519004183	H-loop/switch region; other site
656519004184	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
656519004185	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
656519004186	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
656519004187	ligand binding site [chemical binding]; other site
656519004188	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
656519004189	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
656519004190	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
656519004191	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
656519004192	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
656519004193	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
656519004194	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
656519004195	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
656519004196	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
656519004197	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
656519004198	EamA-like transporter family; Region: EamA; pfam00892
656519004199	EamA-like transporter family; Region: EamA; pfam00892
656519004200	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
656519004201	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
656519004202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
656519004203	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
656519004204	Isochorismatase family; Region: Isochorismatase; pfam00857
656519004205	catalytic triad [active]
656519004206	metal binding site [ion binding]; metal-binding site
656519004207	conserved cis-peptide bond; other site
656519004208	Acylphosphatase; Region: Acylphosphatase; pfam00708
656519004209	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
656519004210	GSH binding site [chemical binding]; other site
656519004211	catalytic residues [active]
656519004212	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
656519004213	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
656519004214	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519004215	Protein of unknown function (DUF964); Region: DUF964; pfam06133
656519004216	flavoprotein, HI0933 family; Region: TIGR00275
656519004217	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
656519004218	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519004219	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519004220	homodimer interface [polypeptide binding]; other site
656519004221	catalytic residue [active]
656519004222	dipeptidase PepV; Reviewed; Region: PRK07318
656519004223	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
656519004224	active site
656519004225	metal binding site [ion binding]; metal-binding site
656519004226	Esterase/lipase [General function prediction only]; Region: COG1647
656519004227	oligoendopeptidase F; Region: pepF; TIGR00181
656519004228	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
656519004229	active site
656519004230	Zn binding site [ion binding]; other site
656519004231	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
656519004232	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
656519004233	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
656519004234	DNA binding site [nucleotide binding]
656519004235	active site
656519004236	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
656519004237	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
656519004238	putative dimer interface [polypeptide binding]; other site
656519004239	putative anticodon binding site; other site
656519004240	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
656519004241	homodimer interface [polypeptide binding]; other site
656519004242	motif 1; other site
656519004243	motif 2; other site
656519004244	active site
656519004245	motif 3; other site
656519004246	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
656519004247	non-heme iron binding site [ion binding]; other site
656519004248	dimer interface [polypeptide binding]; other site
656519004249	aspartate kinase; Reviewed; Region: PRK06635
656519004250	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
656519004251	putative nucleotide binding site [chemical binding]; other site
656519004252	putative catalytic residues [active]
656519004253	putative Mg ion binding site [ion binding]; other site
656519004254	putative aspartate binding site [chemical binding]; other site
656519004255	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
656519004256	putative allosteric regulatory site; other site
656519004257	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
656519004258	putative allosteric regulatory residue; other site
656519004259	homoserine dehydrogenase; Provisional; Region: PRK06349
656519004260	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
656519004261	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
656519004262	homoserine kinase; Provisional; Region: PRK01212
656519004263	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
656519004264	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
656519004265	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
656519004266	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
656519004267	trimer interface [polypeptide binding]; other site
656519004268	active site
656519004269	cell division suppressor protein YneA; Provisional; Region: PRK14125
656519004270	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
656519004271	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
656519004272	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
656519004273	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
656519004274	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
656519004275	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
656519004276	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
656519004277	ATP binding site [chemical binding]; other site
656519004278	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
656519004279	putative Mg++ binding site [ion binding]; other site
656519004280	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
656519004281	endonuclease IV; Provisional; Region: PRK01060
656519004282	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
656519004283	AP (apurinic/apyrimidinic) site pocket; other site
656519004284	DNA interaction; other site
656519004285	Metal-binding active site; metal-binding site
656519004286	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
656519004287	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
656519004288	RNase E interface [polypeptide binding]; other site
656519004289	trimer interface [polypeptide binding]; other site
656519004290	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
656519004291	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
656519004292	RNase E interface [polypeptide binding]; other site
656519004293	trimer interface [polypeptide binding]; other site
656519004294	active site
656519004295	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
656519004296	putative nucleic acid binding region [nucleotide binding]; other site
656519004297	G-X-X-G motif; other site
656519004298	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
656519004299	RNA binding site [nucleotide binding]; other site
656519004300	domain interface; other site
656519004301	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
656519004302	16S/18S rRNA binding site [nucleotide binding]; other site
656519004303	S13e-L30e interaction site [polypeptide binding]; other site
656519004304	25S rRNA binding site [nucleotide binding]; other site
656519004305	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
656519004306	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
656519004307	active site
656519004308	Riboflavin kinase; Region: Flavokinase; pfam01687
656519004309	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
656519004310	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
656519004311	RNA binding site [nucleotide binding]; other site
656519004312	active site
656519004313	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
656519004314	DHH family; Region: DHH; pfam01368
656519004315	DHHA1 domain; Region: DHHA1; pfam02272
656519004316	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
656519004317	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
656519004318	translation initiation factor IF-2; Region: IF-2; TIGR00487
656519004319	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
656519004320	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
656519004321	G1 box; other site
656519004322	putative GEF interaction site [polypeptide binding]; other site
656519004323	GTP/Mg2+ binding site [chemical binding]; other site
656519004324	Switch I region; other site
656519004325	G2 box; other site
656519004326	G3 box; other site
656519004327	Switch II region; other site
656519004328	G4 box; other site
656519004329	G5 box; other site
656519004330	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
656519004331	Translation-initiation factor 2; Region: IF-2; pfam11987
656519004332	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
656519004333	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
656519004334	putative RNA binding cleft [nucleotide binding]; other site
656519004335	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
656519004336	NusA N-terminal domain; Region: NusA_N; pfam08529
656519004337	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
656519004338	RNA binding site [nucleotide binding]; other site
656519004339	homodimer interface [polypeptide binding]; other site
656519004340	NusA-like KH domain; Region: KH_5; pfam13184
656519004341	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
656519004342	G-X-X-G motif; other site
656519004343	ribosome maturation protein RimP; Reviewed; Region: PRK00092
656519004344	Sm and related proteins; Region: Sm_like; cl00259
656519004345	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
656519004346	putative oligomer interface [polypeptide binding]; other site
656519004347	putative RNA binding site [nucleotide binding]; other site
656519004348	DNA polymerase III PolC; Validated; Region: polC; PRK00448
656519004349	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
656519004350	generic binding surface II; other site
656519004351	generic binding surface I; other site
656519004352	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
656519004353	active site
656519004354	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
656519004355	active site
656519004356	catalytic site [active]
656519004357	substrate binding site [chemical binding]; other site
656519004358	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
656519004359	prolyl-tRNA synthetase; Provisional; Region: PRK09194
656519004360	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
656519004361	dimer interface [polypeptide binding]; other site
656519004362	motif 1; other site
656519004363	active site
656519004364	motif 2; other site
656519004365	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
656519004366	putative deacylase active site [active]
656519004367	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
656519004368	active site
656519004369	motif 3; other site
656519004370	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
656519004371	anticodon binding site; other site
656519004372	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
656519004373	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
656519004374	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
656519004375	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
656519004376	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
656519004377	active site
656519004378	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
656519004379	protein binding site [polypeptide binding]; other site
656519004380	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
656519004381	putative substrate binding region [chemical binding]; other site
656519004382	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
656519004383	Domain of unknown function DUF20; Region: UPF0118; pfam01594
656519004384	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
656519004385	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
656519004386	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
656519004387	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
656519004388	catalytic residue [active]
656519004389	putative FPP diphosphate  binding site; other site
656519004390	putative FPP binding hydrophobic cleft; other site
656519004391	dimer interface [polypeptide binding]; other site
656519004392	putative IPP diphosphate binding site; other site
656519004393	ribosome recycling factor; Reviewed; Region: frr; PRK00083
656519004394	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
656519004395	hinge region; other site
656519004396	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
656519004397	putative nucleotide binding site [chemical binding]; other site
656519004398	uridine monophosphate binding site [chemical binding]; other site
656519004399	homohexameric interface [polypeptide binding]; other site
656519004400	elongation factor Ts; Provisional; Region: tsf; PRK09377
656519004401	UBA/TS-N domain; Region: UBA; pfam00627
656519004402	Elongation factor TS; Region: EF_TS; pfam00889
656519004403	Elongation factor TS; Region: EF_TS; pfam00889
656519004404	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
656519004405	rRNA interaction site [nucleotide binding]; other site
656519004406	S8 interaction site; other site
656519004407	putative laminin-1 binding site; other site
656519004408	transcriptional repressor CodY; Validated; Region: PRK04158
656519004409	CodY GAF-like domain; Region: CodY; pfam06018
656519004410	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
656519004411	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
656519004412	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519004413	Walker A motif; other site
656519004414	ATP binding site [chemical binding]; other site
656519004415	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
656519004416	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
656519004417	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
656519004418	active site
656519004419	HslU subunit interaction site [polypeptide binding]; other site
656519004420	DNA topoisomerase I; Validated; Region: PRK05582
656519004421	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
656519004422	active site
656519004423	interdomain interaction site; other site
656519004424	putative metal-binding site [ion binding]; other site
656519004425	nucleotide binding site [chemical binding]; other site
656519004426	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
656519004427	domain I; other site
656519004428	DNA binding groove [nucleotide binding]
656519004429	phosphate binding site [ion binding]; other site
656519004430	domain II; other site
656519004431	domain III; other site
656519004432	nucleotide binding site [chemical binding]; other site
656519004433	catalytic site [active]
656519004434	domain IV; other site
656519004435	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
656519004436	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
656519004437	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
656519004438	Protein of unknown function (DUF494); Region: DUF494; cl01103
656519004439	DNA protecting protein DprA; Region: dprA; TIGR00732
656519004440	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
656519004441	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
656519004442	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
656519004443	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
656519004444	TrkA-N domain; Region: TrkA_N; pfam02254
656519004445	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
656519004446	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
656519004447	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
656519004448	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
656519004449	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
656519004450	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
656519004451	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
656519004452	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
656519004453	N-terminal plug; other site
656519004454	ligand-binding site [chemical binding]; other site
656519004455	hypothetical protein; Reviewed; Region: PRK12497
656519004456	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
656519004457	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
656519004458	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519004459	Walker A motif; other site
656519004460	ATP binding site [chemical binding]; other site
656519004461	Walker B motif; other site
656519004462	arginine finger; other site
656519004463	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
656519004464	QueT transporter; Region: QueT; pfam06177
656519004465	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
656519004466	RNA/DNA hybrid binding site [nucleotide binding]; other site
656519004467	active site
656519004468	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
656519004469	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
656519004470	GTP/Mg2+ binding site [chemical binding]; other site
656519004471	G4 box; other site
656519004472	G5 box; other site
656519004473	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
656519004474	G1 box; other site
656519004475	G1 box; other site
656519004476	GTP/Mg2+ binding site [chemical binding]; other site
656519004477	Switch I region; other site
656519004478	G2 box; other site
656519004479	G2 box; other site
656519004480	Switch I region; other site
656519004481	G3 box; other site
656519004482	G3 box; other site
656519004483	Switch II region; other site
656519004484	Switch II region; other site
656519004485	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
656519004486	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
656519004487	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
656519004488	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
656519004489	RimM N-terminal domain; Region: RimM; pfam01782
656519004490	PRC-barrel domain; Region: PRC; pfam05239
656519004491	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
656519004492	hypothetical protein; Provisional; Region: PRK00468
656519004493	G-X-X-G motif; other site
656519004494	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
656519004495	signal recognition particle protein; Provisional; Region: PRK10867
656519004496	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
656519004497	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
656519004498	P loop; other site
656519004499	GTP binding site [chemical binding]; other site
656519004500	Signal peptide binding domain; Region: SRP_SPB; pfam02978
656519004501	putative DNA-binding protein; Validated; Region: PRK00118
656519004502	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
656519004503	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
656519004504	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
656519004505	P loop; other site
656519004506	GTP binding site [chemical binding]; other site
656519004507	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
656519004508	AAA domain; Region: AAA_23; pfam13476
656519004509	Walker A/P-loop; other site
656519004510	ATP binding site [chemical binding]; other site
656519004511	Q-loop/lid; other site
656519004512	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
656519004513	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
656519004514	Walker B; other site
656519004515	D-loop; other site
656519004516	H-loop/switch region; other site
656519004517	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
656519004518	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
656519004519	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519004520	RNA binding surface [nucleotide binding]; other site
656519004521	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
656519004522	active site
656519004523	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
656519004524	ScpA/B protein; Region: ScpA_ScpB; cl00598
656519004525	Peptidase family M50; Region: Peptidase_M50; pfam02163
656519004526	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
656519004527	putative substrate binding region [chemical binding]; other site
656519004528	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
656519004529	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
656519004530	active site
656519004531	NTP binding site [chemical binding]; other site
656519004532	metal binding triad [ion binding]; metal-binding site
656519004533	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
656519004534	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
656519004535	active site
656519004536	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
656519004537	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
656519004538	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
656519004539	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
656519004540	purine nucleoside phosphorylase; Provisional; Region: PRK08202
656519004541	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
656519004542	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
656519004543	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
656519004544	PHP-associated; Region: PHP_C; pfam13263
656519004545	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
656519004546	dimer interface [polypeptide binding]; other site
656519004547	ADP-ribose binding site [chemical binding]; other site
656519004548	active site
656519004549	nudix motif; other site
656519004550	metal binding site [ion binding]; metal-binding site
656519004551	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
656519004552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519004553	active site
656519004554	phosphorylation site [posttranslational modification]
656519004555	intermolecular recognition site; other site
656519004556	dimerization interface [polypeptide binding]; other site
656519004557	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
656519004558	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
656519004559	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
656519004560	Walker A/P-loop; other site
656519004561	ATP binding site [chemical binding]; other site
656519004562	Q-loop/lid; other site
656519004563	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
656519004564	ABC transporter signature motif; other site
656519004565	Walker B; other site
656519004566	D-loop; other site
656519004567	H-loop/switch region; other site
656519004568	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
656519004569	ATP-NAD kinase; Region: NAD_kinase; pfam01513
656519004570	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
656519004571	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519004572	RNA binding surface [nucleotide binding]; other site
656519004573	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
656519004574	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
656519004575	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
656519004576	TPP-binding site; other site
656519004577	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
656519004578	PYR/PP interface [polypeptide binding]; other site
656519004579	dimer interface [polypeptide binding]; other site
656519004580	TPP binding site [chemical binding]; other site
656519004581	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519004582	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
656519004583	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
656519004584	substrate binding pocket [chemical binding]; other site
656519004585	chain length determination region; other site
656519004586	substrate-Mg2+ binding site; other site
656519004587	catalytic residues [active]
656519004588	aspartate-rich region 1; other site
656519004589	active site lid residues [active]
656519004590	aspartate-rich region 2; other site
656519004591	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
656519004592	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
656519004593	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
656519004594	generic binding surface II; other site
656519004595	generic binding surface I; other site
656519004596	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519004597	putative oxidoreductase; Provisional; Region: PRK12831
656519004598	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519004599	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
656519004600	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
656519004601	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
656519004602	FAD binding pocket [chemical binding]; other site
656519004603	FAD binding motif [chemical binding]; other site
656519004604	phosphate binding motif [ion binding]; other site
656519004605	beta-alpha-beta structure motif; other site
656519004606	NAD binding pocket [chemical binding]; other site
656519004607	Iron coordination center [ion binding]; other site
656519004608	aspartate aminotransferase; Provisional; Region: PRK05764
656519004609	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519004610	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519004611	homodimer interface [polypeptide binding]; other site
656519004612	catalytic residue [active]
656519004613	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
656519004614	putative RNA binding site [nucleotide binding]; other site
656519004615	Asp23 family; Region: Asp23; pfam03780
656519004616	Asp23 family; Region: Asp23; pfam03780
656519004617	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
656519004618	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519004619	elongation factor P; Validated; Region: PRK00529
656519004620	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
656519004621	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
656519004622	RNA binding site [nucleotide binding]; other site
656519004623	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
656519004624	RNA binding site [nucleotide binding]; other site
656519004625	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
656519004626	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
656519004627	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
656519004628	active site
656519004629	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
656519004630	Dehydroquinase class II; Region: DHquinase_II; pfam01220
656519004631	trimer interface [polypeptide binding]; other site
656519004632	active site
656519004633	dimer interface [polypeptide binding]; other site
656519004634	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
656519004635	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
656519004636	ADP binding site [chemical binding]; other site
656519004637	magnesium binding site [ion binding]; other site
656519004638	putative shikimate binding site; other site
656519004639	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
656519004640	active site
656519004641	dimer interface [polypeptide binding]; other site
656519004642	metal binding site [ion binding]; metal-binding site
656519004643	O-Antigen ligase; Region: Wzy_C; pfam04932
656519004644	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
656519004645	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
656519004646	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
656519004647	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
656519004648	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
656519004649	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
656519004650	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
656519004651	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
656519004652	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
656519004653	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
656519004654	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
656519004655	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
656519004656	Walker A motif; other site
656519004657	ATP binding site [chemical binding]; other site
656519004658	Walker B motif; other site
656519004659	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
656519004660	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
656519004661	active site
656519004662	catalytic residues [active]
656519004663	metal binding site [ion binding]; metal-binding site
656519004664	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
656519004665	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
656519004666	tartrate dehydrogenase; Region: TTC; TIGR02089
656519004667	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
656519004668	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
656519004669	substrate binding site [chemical binding]; other site
656519004670	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
656519004671	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
656519004672	substrate binding site [chemical binding]; other site
656519004673	ligand binding site [chemical binding]; other site
656519004674	2-isopropylmalate synthase; Validated; Region: PRK00915
656519004675	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
656519004676	active site
656519004677	catalytic residues [active]
656519004678	metal binding site [ion binding]; metal-binding site
656519004679	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
656519004680	ketol-acid reductoisomerase; Provisional; Region: PRK05479
656519004681	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
656519004682	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
656519004683	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
656519004684	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
656519004685	putative valine binding site [chemical binding]; other site
656519004686	dimer interface [polypeptide binding]; other site
656519004687	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
656519004688	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
656519004689	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
656519004690	PYR/PP interface [polypeptide binding]; other site
656519004691	dimer interface [polypeptide binding]; other site
656519004692	TPP binding site [chemical binding]; other site
656519004693	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
656519004694	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
656519004695	TPP-binding site [chemical binding]; other site
656519004696	dimer interface [polypeptide binding]; other site
656519004697	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
656519004698	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
656519004699	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
656519004700	homodimer interface [polypeptide binding]; other site
656519004701	substrate-cofactor binding pocket; other site
656519004702	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519004703	catalytic residue [active]
656519004704	Transposase domain (DUF772); Region: DUF772; pfam05598
656519004705	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
656519004706	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
656519004707	DNA binding residues [nucleotide binding]
656519004708	dimerization interface [polypeptide binding]; other site
656519004709	Secretin and TonB N terminus short domain; Region: STN; pfam07660
656519004710	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
656519004711	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
656519004712	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
656519004713	Pilus assembly protein, PilO; Region: PilO; cl01234
656519004714	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
656519004715	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
656519004716	Cell division protein FtsA; Region: FtsA; cl17206
656519004717	Competence protein A; Region: Competence_A; pfam11104
656519004718	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
656519004719	nucleotide binding site [chemical binding]; other site
656519004720	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
656519004721	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
656519004722	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
656519004723	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
656519004724	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
656519004725	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
656519004726	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
656519004727	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
656519004728	Walker A motif; other site
656519004729	ATP binding site [chemical binding]; other site
656519004730	Walker B motif; other site
656519004731	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
656519004732	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
656519004733	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
656519004734	Walker A motif; other site
656519004735	ATP binding site [chemical binding]; other site
656519004736	Walker B motif; other site
656519004737	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
656519004738	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
656519004739	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
656519004740	shikimate binding site; other site
656519004741	NAD(P) binding site [chemical binding]; other site
656519004742	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
656519004743	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
656519004744	ligand binding site [chemical binding]; other site
656519004745	flexible hinge region; other site
656519004746	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
656519004747	non-specific DNA interactions [nucleotide binding]; other site
656519004748	DNA binding site [nucleotide binding]
656519004749	sequence specific DNA binding site [nucleotide binding]; other site
656519004750	putative cAMP binding site [chemical binding]; other site
656519004751	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
656519004752	metal binding site 2 [ion binding]; metal-binding site
656519004753	putative DNA binding helix; other site
656519004754	metal binding site 1 [ion binding]; metal-binding site
656519004755	dimer interface [polypeptide binding]; other site
656519004756	structural Zn2+ binding site [ion binding]; other site
656519004757	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
656519004758	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
656519004759	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
656519004760	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
656519004761	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
656519004762	Peptidase family U32; Region: Peptidase_U32; pfam01136
656519004763	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
656519004764	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519004765	S-adenosylmethionine binding site [chemical binding]; other site
656519004766	YceG-like family; Region: YceG; pfam02618
656519004767	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
656519004768	dimerization interface [polypeptide binding]; other site
656519004769	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
656519004770	hypothetical protein; Provisional; Region: PRK05473
656519004771	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
656519004772	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
656519004773	motif 1; other site
656519004774	active site
656519004775	motif 2; other site
656519004776	motif 3; other site
656519004777	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
656519004778	DHHA1 domain; Region: DHHA1; pfam02272
656519004779	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
656519004780	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
656519004781	active site
656519004782	HIGH motif; other site
656519004783	dimer interface [polypeptide binding]; other site
656519004784	KMSKS motif; other site
656519004785	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519004786	RNA binding surface [nucleotide binding]; other site
656519004787	Transglycosylase; Region: Transgly; pfam00912
656519004788	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
656519004789	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
656519004790	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
656519004791	MutS domain III; Region: MutS_III; pfam05192
656519004792	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
656519004793	Walker A/P-loop; other site
656519004794	ATP binding site [chemical binding]; other site
656519004795	Q-loop/lid; other site
656519004796	ABC transporter signature motif; other site
656519004797	Walker B; other site
656519004798	D-loop; other site
656519004799	H-loop/switch region; other site
656519004800	Smr domain; Region: Smr; pfam01713
656519004801	hypothetical protein; Provisional; Region: PRK08609
656519004802	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
656519004803	active site
656519004804	primer binding site [nucleotide binding]; other site
656519004805	NTP  binding site [chemical binding]; other site
656519004806	metal binding triad [ion binding]; metal-binding site
656519004807	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
656519004808	active site
656519004809	Colicin V production protein; Region: Colicin_V; pfam02674
656519004810	Cell division protein ZapA; Region: ZapA; pfam05164
656519004811	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
656519004812	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
656519004813	putative tRNA-binding site [nucleotide binding]; other site
656519004814	B3/4 domain; Region: B3_4; pfam03483
656519004815	tRNA synthetase B5 domain; Region: B5; smart00874
656519004816	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
656519004817	dimer interface [polypeptide binding]; other site
656519004818	motif 1; other site
656519004819	motif 3; other site
656519004820	motif 2; other site
656519004821	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
656519004822	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
656519004823	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
656519004824	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
656519004825	dimer interface [polypeptide binding]; other site
656519004826	motif 1; other site
656519004827	active site
656519004828	motif 2; other site
656519004829	motif 3; other site
656519004830	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
656519004831	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
656519004832	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
656519004833	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
656519004834	23S rRNA binding site [nucleotide binding]; other site
656519004835	L21 binding site [polypeptide binding]; other site
656519004836	L13 binding site [polypeptide binding]; other site
656519004837	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
656519004838	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
656519004839	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
656519004840	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
656519004841	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
656519004842	FMN binding site [chemical binding]; other site
656519004843	dimer interface [polypeptide binding]; other site
656519004844	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
656519004845	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
656519004846	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
656519004847	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
656519004848	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
656519004849	active site
656519004850	dimer interface [polypeptide binding]; other site
656519004851	motif 1; other site
656519004852	motif 2; other site
656519004853	motif 3; other site
656519004854	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
656519004855	anticodon binding site; other site
656519004856	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
656519004857	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
656519004858	MgtC family; Region: MgtC; pfam02308
656519004859	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004860	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004861	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004862	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004863	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004864	YibE/F-like protein; Region: YibE_F; pfam07907
656519004865	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
656519004866	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
656519004867	active site
656519004868	dimer interface [polypeptide binding]; other site
656519004869	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
656519004870	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519004871	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519004872	Integrase core domain; Region: rve; pfam00665
656519004873	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519004874	Transposase; Region: HTH_Tnp_1; pfam01527
656519004875	HTH-like domain; Region: HTH_21; pfam13276
656519004876	Integrase core domain; Region: rve; pfam00665
656519004877	Integrase core domain; Region: rve_3; pfam13683
656519004878	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004879	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004880	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004881	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
656519004882	YibE/F-like protein; Region: YibE_F; pfam07907
656519004883	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
656519004884	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
656519004885	active site
656519004886	dimer interface [polypeptide binding]; other site
656519004887	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
656519004888	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
656519004889	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
656519004890	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
656519004891	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
656519004892	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
656519004893	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
656519004894	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
656519004895	Family of unknown function (DUF694); Region: DUF694; pfam05107
656519004896	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
656519004897	Predicted transcriptional regulator [Transcription]; Region: COG2378
656519004898	HTH domain; Region: HTH_11; cl17392
656519004899	WYL domain; Region: WYL; pfam13280
656519004900	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
656519004901	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
656519004902	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
656519004903	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
656519004904	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519004905	motif II; other site
656519004906	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
656519004907	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
656519004908	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
656519004909	putative substrate binding site [chemical binding]; other site
656519004910	putative ATP binding site [chemical binding]; other site
656519004911	4Fe-4S binding domain; Region: Fer4_5; pfam12801
656519004912	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519004913	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519004914	manganese transport transcriptional regulator; Provisional; Region: PRK03902
656519004915	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
656519004916	DNA binding site [nucleotide binding]
656519004917	sequence specific DNA binding site [nucleotide binding]; other site
656519004918	putative cAMP binding site [chemical binding]; other site
656519004919	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
656519004920	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
656519004921	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519004922	ABC-ATPase subunit  interface; other site
656519004923	dimer interface [polypeptide binding]; other site
656519004924	putative PBP binding regions; other site
656519004925	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
656519004926	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
656519004927	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
656519004928	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519004929	intersubunit interface [polypeptide binding]; other site
656519004930	Predicted membrane protein [Function unknown]; Region: COG4818
656519004931	flavoprotein, HI0933 family; Region: TIGR00275
656519004932	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
656519004933	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
656519004934	active site
656519004935	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
656519004936	Mechanosensitive ion channel; Region: MS_channel; pfam00924
656519004937	FAD binding domain; Region: FAD_binding_4; pfam01565
656519004938	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
656519004939	Integrase core domain; Region: rve; pfam00665
656519004940	DDE domain; Region: DDE_Tnp_IS240; pfam13610
656519004941	Integrase core domain; Region: rve_3; cl15866
656519004942	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
656519004943	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
656519004944	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
656519004945	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
656519004946	Ligand binding site [chemical binding]; other site
656519004947	Electron transfer flavoprotein domain; Region: ETF; pfam01012
656519004948	Uncharacterized membrane protein [Function unknown]; Region: COG3949
656519004949	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
656519004950	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
656519004951	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
656519004952	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
656519004953	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
656519004954	Peptidase family M23; Region: Peptidase_M23; pfam01551
656519004955	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
656519004956	putative hydrolase; Provisional; Region: PRK02113
656519004957	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
656519004958	Predicted membrane protein [Function unknown]; Region: COG3601
656519004959	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
656519004960	Stage II sporulation protein; Region: SpoIID; pfam08486
656519004961	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
656519004962	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
656519004963	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
656519004964	putative active site [active]
656519004965	PhoH-like protein; Region: PhoH; pfam02562
656519004966	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
656519004967	trimer interface [polypeptide binding]; other site
656519004968	putative Zn binding site [ion binding]; other site
656519004969	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
656519004970	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
656519004971	minor groove reading motif; other site
656519004972	helix-hairpin-helix signature motif; other site
656519004973	substrate binding pocket [chemical binding]; other site
656519004974	active site
656519004975	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
656519004976	Uncharacterized conserved protein [Function unknown]; Region: COG5663
656519004977	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
656519004978	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
656519004979	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
656519004980	active site
656519004981	epoxyqueuosine reductase; Region: TIGR00276
656519004982	Major Facilitator Superfamily; Region: MFS_1; pfam07690
656519004983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519004984	putative substrate translocation pore; other site
656519004985	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
656519004986	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
656519004987	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
656519004988	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
656519004989	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
656519004990	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
656519004991	Uncharacterized conserved protein [Function unknown]; Region: COG1615
656519004992	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
656519004993	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
656519004994	active site
656519004995	putative substrate binding pocket [chemical binding]; other site
656519004996	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
656519004997	photolyase PhrII; Region: phr2; TIGR00591
656519004998	DNA photolyase; Region: DNA_photolyase; pfam00875
656519004999	Mechanosensitive ion channel; Region: MS_channel; pfam00924
656519005000	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
656519005001	IHF - DNA interface [nucleotide binding]; other site
656519005002	IHF dimer interface [polypeptide binding]; other site
656519005003	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
656519005004	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
656519005005	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
656519005006	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
656519005007	GTP-binding protein Der; Reviewed; Region: PRK00093
656519005008	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
656519005009	G1 box; other site
656519005010	GTP/Mg2+ binding site [chemical binding]; other site
656519005011	Switch I region; other site
656519005012	G2 box; other site
656519005013	Switch II region; other site
656519005014	G3 box; other site
656519005015	G4 box; other site
656519005016	G5 box; other site
656519005017	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
656519005018	G1 box; other site
656519005019	GTP/Mg2+ binding site [chemical binding]; other site
656519005020	Switch I region; other site
656519005021	G2 box; other site
656519005022	G3 box; other site
656519005023	Switch II region; other site
656519005024	G4 box; other site
656519005025	G5 box; other site
656519005026	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
656519005027	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
656519005028	Protein of unknown function (DUF512); Region: DUF512; pfam04459
656519005029	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
656519005030	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
656519005031	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
656519005032	RNA binding site [nucleotide binding]; other site
656519005033	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
656519005034	RNA binding site [nucleotide binding]; other site
656519005035	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519005036	RNA binding site [nucleotide binding]; other site
656519005037	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519005038	RNA binding site [nucleotide binding]; other site
656519005039	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
656519005040	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
656519005041	putative acyl-acceptor binding pocket; other site
656519005042	cytidylate kinase; Provisional; Region: cmk; PRK00023
656519005043	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
656519005044	CMP-binding site; other site
656519005045	The sites determining sugar specificity; other site
656519005046	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
656519005047	homotrimer interaction site [polypeptide binding]; other site
656519005048	active site
656519005049	ribonuclease III; Reviewed; Region: rnc; PRK00102
656519005050	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
656519005051	dimerization interface [polypeptide binding]; other site
656519005052	active site
656519005053	metal binding site [ion binding]; metal-binding site
656519005054	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
656519005055	dsRNA binding site [nucleotide binding]; other site
656519005056	acyl carrier protein; Provisional; Region: acpP; PRK00982
656519005057	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
656519005058	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
656519005059	NAD(P) binding site [chemical binding]; other site
656519005060	homotetramer interface [polypeptide binding]; other site
656519005061	homodimer interface [polypeptide binding]; other site
656519005062	active site
656519005063	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
656519005064	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
656519005065	FMN binding site [chemical binding]; other site
656519005066	substrate binding site [chemical binding]; other site
656519005067	putative catalytic residue [active]
656519005068	putative phosphate acyltransferase; Provisional; Region: PRK05331
656519005069	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
656519005070	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
656519005071	propionate/acetate kinase; Provisional; Region: PRK12379
656519005072	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
656519005073	nucleotide binding site [chemical binding]; other site
656519005074	butyrate kinase; Provisional; Region: PRK03011
656519005075	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
656519005076	hypothetical protein; Provisional; Region: PRK13670
656519005077	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
656519005078	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
656519005079	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
656519005080	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
656519005081	hypothetical protein; Provisional; Region: PRK10279
656519005082	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
656519005083	nucleophile elbow; other site
656519005084	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
656519005085	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
656519005086	Ligand Binding Site [chemical binding]; other site
656519005087	hypothetical protein; Provisional; Region: PRK11770
656519005088	Domain of unknown function (DUF307); Region: DUF307; pfam03733
656519005089	Domain of unknown function (DUF307); Region: DUF307; pfam03733
656519005090	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
656519005091	UbiA prenyltransferase family; Region: UbiA; pfam01040
656519005092	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
656519005093	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
656519005094	active site
656519005095	(T/H)XGH motif; other site
656519005096	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
656519005097	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519005098	S-adenosylmethionine binding site [chemical binding]; other site
656519005099	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
656519005100	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
656519005101	generic binding surface II; other site
656519005102	ssDNA binding site; other site
656519005103	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
656519005104	ATP binding site [chemical binding]; other site
656519005105	putative Mg++ binding site [ion binding]; other site
656519005106	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519005107	nucleotide binding region [chemical binding]; other site
656519005108	ATP-binding site [chemical binding]; other site
656519005109	EDD domain protein, DegV family; Region: DegV; TIGR00762
656519005110	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
656519005111	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
656519005112	DAK2 domain; Region: Dak2; pfam02734
656519005113	Asp23 family; Region: Asp23; pfam03780
656519005114	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
656519005115	Thiamine pyrophosphokinase; Region: TPK; cd07995
656519005116	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
656519005117	active site
656519005118	dimerization interface [polypeptide binding]; other site
656519005119	thiamine binding site [chemical binding]; other site
656519005120	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
656519005121	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
656519005122	substrate binding site [chemical binding]; other site
656519005123	hexamer interface [polypeptide binding]; other site
656519005124	metal binding site [ion binding]; metal-binding site
656519005125	GTPase RsgA; Reviewed; Region: PRK00098
656519005126	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519005127	RNA binding site [nucleotide binding]; other site
656519005128	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
656519005129	GTPase/Zn-binding domain interface [polypeptide binding]; other site
656519005130	GTP/Mg2+ binding site [chemical binding]; other site
656519005131	G4 box; other site
656519005132	G5 box; other site
656519005133	G1 box; other site
656519005134	Switch I region; other site
656519005135	G2 box; other site
656519005136	G3 box; other site
656519005137	Switch II region; other site
656519005138	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
656519005139	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
656519005140	active site
656519005141	ATP binding site [chemical binding]; other site
656519005142	substrate binding site [chemical binding]; other site
656519005143	activation loop (A-loop); other site
656519005144	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
656519005145	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
656519005146	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
656519005147	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
656519005148	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
656519005149	Protein phosphatase 2C; Region: PP2C; pfam00481
656519005150	active site
656519005151	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
656519005152	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519005153	FeS/SAM binding site; other site
656519005154	16S rRNA methyltransferase B; Provisional; Region: PRK14902
656519005155	NusB family; Region: NusB; pfam01029
656519005156	putative RNA binding site [nucleotide binding]; other site
656519005157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519005158	S-adenosylmethionine binding site [chemical binding]; other site
656519005159	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
656519005160	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
656519005161	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
656519005162	putative active site [active]
656519005163	substrate binding site [chemical binding]; other site
656519005164	putative cosubstrate binding site; other site
656519005165	catalytic site [active]
656519005166	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
656519005167	substrate binding site [chemical binding]; other site
656519005168	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
656519005169	active site
656519005170	catalytic residues [active]
656519005171	metal binding site [ion binding]; metal-binding site
656519005172	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
656519005173	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
656519005174	S-adenosylmethionine synthetase; Validated; Region: PRK05250
656519005175	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
656519005176	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
656519005177	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
656519005178	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
656519005179	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
656519005180	Flavoprotein; Region: Flavoprotein; pfam02441
656519005181	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
656519005182	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
656519005183	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
656519005184	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
656519005185	catalytic site [active]
656519005186	G-X2-G-X-G-K; other site
656519005187	hypothetical protein; Provisional; Region: PRK04323
656519005188	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
656519005189	Domain of unknown function (DUF814); Region: DUF814; pfam05670
656519005190	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
656519005191	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
656519005192	elongation factor G; Reviewed; Region: PRK12740
656519005193	G1 box; other site
656519005194	putative GEF interaction site [polypeptide binding]; other site
656519005195	GTP/Mg2+ binding site [chemical binding]; other site
656519005196	Switch I region; other site
656519005197	G2 box; other site
656519005198	G3 box; other site
656519005199	Switch II region; other site
656519005200	G4 box; other site
656519005201	G5 box; other site
656519005202	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
656519005203	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
656519005204	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
656519005205	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
656519005206	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
656519005207	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
656519005208	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
656519005209	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519005210	RNA binding surface [nucleotide binding]; other site
656519005211	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
656519005212	active site
656519005213	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
656519005214	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
656519005215	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
656519005216	HIGH motif; other site
656519005217	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
656519005218	active site
656519005219	KMSKS motif; other site
656519005220	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
656519005221	tRNA binding surface [nucleotide binding]; other site
656519005222	anticodon binding site; other site
656519005223	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
656519005224	DivIVA protein; Region: DivIVA; pfam05103
656519005225	DivIVA domain; Region: DivI1A_domain; TIGR03544
656519005226	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
656519005227	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519005228	RNA binding surface [nucleotide binding]; other site
656519005229	YGGT family; Region: YGGT; pfam02325
656519005230	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
656519005231	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
656519005232	catalytic residue [active]
656519005233	HlyD family secretion protein; Region: HlyD_2; pfam12700
656519005234	putative membrane fusion protein; Region: TIGR02828
656519005235	cell division protein FtsZ; Validated; Region: PRK09330
656519005236	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
656519005237	nucleotide binding site [chemical binding]; other site
656519005238	SulA interaction site; other site
656519005239	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
656519005240	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
656519005241	nucleotide binding site [chemical binding]; other site
656519005242	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
656519005243	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
656519005244	Cell division protein FtsA; Region: FtsA; pfam14450
656519005245	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
656519005246	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
656519005247	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
656519005248	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
656519005249	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
656519005250	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519005251	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
656519005252	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
656519005253	homodimer interface [polypeptide binding]; other site
656519005254	active site
656519005255	cell division protein FtsW; Region: ftsW; TIGR02614
656519005256	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
656519005257	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
656519005258	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519005259	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
656519005260	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
656519005261	Mg++ binding site [ion binding]; other site
656519005262	putative catalytic motif [active]
656519005263	putative substrate binding site [chemical binding]; other site
656519005264	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
656519005265	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
656519005266	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
656519005267	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519005268	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
656519005269	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
656519005270	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
656519005271	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
656519005272	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
656519005273	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
656519005274	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
656519005275	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
656519005276	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
656519005277	MraW methylase family; Region: Methyltransf_5; pfam01795
656519005278	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
656519005279	cell division protein MraZ; Reviewed; Region: PRK00326
656519005280	MraZ protein; Region: MraZ; pfam02381
656519005281	MraZ protein; Region: MraZ; pfam02381
656519005282	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
656519005283	active site
656519005284	DNA polymerase IV; Validated; Region: PRK02406
656519005285	DNA binding site [nucleotide binding]
656519005286	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
656519005287	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
656519005288	ATP-grasp domain; Region: ATP-grasp_4; cl17255
656519005289	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
656519005290	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
656519005291	active site
656519005292	HIGH motif; other site
656519005293	dimer interface [polypeptide binding]; other site
656519005294	KMSKS motif; other site
656519005295	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
656519005296	metal binding site 2 [ion binding]; metal-binding site
656519005297	putative DNA binding helix; other site
656519005298	metal binding site 1 [ion binding]; metal-binding site
656519005299	dimer interface [polypeptide binding]; other site
656519005300	structural Zn2+ binding site [ion binding]; other site
656519005301	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
656519005302	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
656519005303	RNA/DNA hybrid binding site [nucleotide binding]; other site
656519005304	active site
656519005305	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
656519005306	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
656519005307	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
656519005308	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
656519005309	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519005310	dimerization domain swap beta strand [polypeptide binding]; other site
656519005311	regulatory protein interface [polypeptide binding]; other site
656519005312	active site
656519005313	regulatory phosphorylation site [posttranslational modification]; other site
656519005314	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
656519005315	Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862
656519005316	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
656519005317	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
656519005318	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
656519005319	Predicted dehydrogenase [General function prediction only]; Region: COG0579
656519005320	hydroxyglutarate oxidase; Provisional; Region: PRK11728
656519005321	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
656519005322	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
656519005323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005324	dimer interface [polypeptide binding]; other site
656519005325	conserved gate region; other site
656519005326	ABC-ATPase subunit interface; other site
656519005327	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519005328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005329	dimer interface [polypeptide binding]; other site
656519005330	conserved gate region; other site
656519005331	putative PBP binding loops; other site
656519005332	ABC-ATPase subunit interface; other site
656519005333	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519005334	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
656519005335	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
656519005336	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
656519005337	Ligand Binding Site [chemical binding]; other site
656519005338	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
656519005339	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
656519005340	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519005341	catalytic residue [active]
656519005342	Predicted transcriptional regulator [Transcription]; Region: COG1959
656519005343	Transcriptional regulator; Region: Rrf2; cl17282
656519005344	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
656519005345	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
656519005346	recombination factor protein RarA; Reviewed; Region: PRK13342
656519005347	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519005348	Walker A motif; other site
656519005349	ATP binding site [chemical binding]; other site
656519005350	Walker B motif; other site
656519005351	arginine finger; other site
656519005352	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
656519005353	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
656519005354	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
656519005355	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
656519005356	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
656519005357	dimer interface [polypeptide binding]; other site
656519005358	anticodon binding site; other site
656519005359	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
656519005360	homodimer interface [polypeptide binding]; other site
656519005361	motif 1; other site
656519005362	active site
656519005363	motif 2; other site
656519005364	GAD domain; Region: GAD; pfam02938
656519005365	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
656519005366	motif 3; other site
656519005367	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
656519005368	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
656519005369	dimer interface [polypeptide binding]; other site
656519005370	motif 1; other site
656519005371	active site
656519005372	motif 2; other site
656519005373	motif 3; other site
656519005374	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
656519005375	anticodon binding site; other site
656519005376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519005377	TPR motif; other site
656519005378	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519005379	binding surface
656519005380	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519005381	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
656519005382	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
656519005383	putative active site [active]
656519005384	dimerization interface [polypeptide binding]; other site
656519005385	putative tRNAtyr binding site [nucleotide binding]; other site
656519005386	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
656519005387	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519005388	Zn2+ binding site [ion binding]; other site
656519005389	Mg2+ binding site [ion binding]; other site
656519005390	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
656519005391	synthetase active site [active]
656519005392	NTP binding site [chemical binding]; other site
656519005393	metal binding site [ion binding]; metal-binding site
656519005394	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
656519005395	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
656519005396	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519005397	active site
656519005398	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
656519005399	DHH family; Region: DHH; pfam01368
656519005400	DHHA1 domain; Region: DHHA1; pfam02272
656519005401	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
656519005402	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
656519005403	ABC1 family; Region: ABC1; cl17513
656519005404	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
656519005405	Protein export membrane protein; Region: SecD_SecF; pfam02355
656519005406	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
656519005407	protein-export membrane protein SecD; Region: secD; TIGR01129
656519005408	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
656519005409	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
656519005410	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
656519005411	Catalytic site [active]
656519005412	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
656519005413	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
656519005414	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
656519005415	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
656519005416	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
656519005417	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
656519005418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519005419	Walker A motif; other site
656519005420	ATP binding site [chemical binding]; other site
656519005421	Walker B motif; other site
656519005422	arginine finger; other site
656519005423	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
656519005424	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
656519005425	RuvA N terminal domain; Region: RuvA_N; pfam01330
656519005426	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
656519005427	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
656519005428	active site
656519005429	putative DNA-binding cleft [nucleotide binding]; other site
656519005430	dimer interface [polypeptide binding]; other site
656519005431	hypothetical protein; Validated; Region: PRK00110
656519005432	Uncharacterized conserved protein [Function unknown]; Region: COG0327
656519005433	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
656519005434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
656519005435	Uncharacterized conserved protein [Function unknown]; Region: COG0327
656519005436	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
656519005437	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
656519005438	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
656519005439	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
656519005440	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
656519005441	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
656519005442	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
656519005443	DNA binding residues [nucleotide binding]
656519005444	DNA primase, catalytic core; Region: dnaG; TIGR01391
656519005445	CHC2 zinc finger; Region: zf-CHC2; pfam01807
656519005446	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
656519005447	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
656519005448	active site
656519005449	metal binding site [ion binding]; metal-binding site
656519005450	interdomain interaction site; other site
656519005451	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
656519005452	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
656519005453	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519005454	Zn2+ binding site [ion binding]; other site
656519005455	Mg2+ binding site [ion binding]; other site
656519005456	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
656519005457	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
656519005458	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
656519005459	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
656519005460	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
656519005461	dimer interface [polypeptide binding]; other site
656519005462	motif 1; other site
656519005463	active site
656519005464	motif 2; other site
656519005465	motif 3; other site
656519005466	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
656519005467	Recombination protein O N terminal; Region: RecO_N; pfam11967
656519005468	Recombination protein O C terminal; Region: RecO_C; pfam02565
656519005469	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
656519005470	intersubunit interface [polypeptide binding]; other site
656519005471	active site
656519005472	catalytic residue [active]
656519005473	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
656519005474	MgtE intracellular N domain; Region: MgtE_N; pfam03448
656519005475	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
656519005476	Divalent cation transporter; Region: MgtE; pfam01769
656519005477	GTPase Era; Reviewed; Region: era; PRK00089
656519005478	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
656519005479	G1 box; other site
656519005480	GTP/Mg2+ binding site [chemical binding]; other site
656519005481	Switch I region; other site
656519005482	G2 box; other site
656519005483	Switch II region; other site
656519005484	G3 box; other site
656519005485	G4 box; other site
656519005486	G5 box; other site
656519005487	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
656519005488	active site
656519005489	catalytic motif [active]
656519005490	Zn binding site [ion binding]; other site
656519005491	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
656519005492	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
656519005493	Domain of unknown function DUF21; Region: DUF21; pfam01595
656519005494	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
656519005495	Transporter associated domain; Region: CorC_HlyC; smart01091
656519005496	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
656519005497	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
656519005498	active site
656519005499	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
656519005500	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
656519005501	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
656519005502	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519005503	Zn2+ binding site [ion binding]; other site
656519005504	Mg2+ binding site [ion binding]; other site
656519005505	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
656519005506	PhoH-like protein; Region: PhoH; pfam02562
656519005507	hypothetical protein; Provisional; Region: PRK13665
656519005508	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
656519005509	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
656519005510	dimer interface [polypeptide binding]; other site
656519005511	active site residues [active]
656519005512	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
656519005513	Yqey-like protein; Region: YqeY; pfam09424
656519005514	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
656519005515	nucleotide binding site/active site [active]
656519005516	HIT family signature motif; other site
656519005517	catalytic residue [active]
656519005518	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
656519005519	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
656519005520	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519005521	FeS/SAM binding site; other site
656519005522	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
656519005523	chaperone protein DnaJ; Provisional; Region: PRK10767
656519005524	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
656519005525	HSP70 interaction site [polypeptide binding]; other site
656519005526	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
656519005527	substrate binding site [polypeptide binding]; other site
656519005528	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
656519005529	Zn binding sites [ion binding]; other site
656519005530	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
656519005531	dimer interface [polypeptide binding]; other site
656519005532	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
656519005533	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
656519005534	nucleotide binding site [chemical binding]; other site
656519005535	NEF interaction site [polypeptide binding]; other site
656519005536	SBD interface [polypeptide binding]; other site
656519005537	GrpE; Region: GrpE; pfam01025
656519005538	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
656519005539	dimer interface [polypeptide binding]; other site
656519005540	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
656519005541	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
656519005542	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
656519005543	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
656519005544	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519005545	FeS/SAM binding site; other site
656519005546	HemN C-terminal domain; Region: HemN_C; pfam06969
656519005547	GTP-binding protein LepA; Provisional; Region: PRK05433
656519005548	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
656519005549	G1 box; other site
656519005550	putative GEF interaction site [polypeptide binding]; other site
656519005551	GTP/Mg2+ binding site [chemical binding]; other site
656519005552	Switch I region; other site
656519005553	G2 box; other site
656519005554	G3 box; other site
656519005555	Switch II region; other site
656519005556	G4 box; other site
656519005557	G5 box; other site
656519005558	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
656519005559	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
656519005560	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
656519005561	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
656519005562	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
656519005563	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
656519005564	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
656519005565	Competence protein; Region: Competence; pfam03772
656519005566	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
656519005567	SLBB domain; Region: SLBB; pfam10531
656519005568	comEA protein; Region: comE; TIGR01259
656519005569	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
656519005570	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
656519005571	ATP-binding site [chemical binding]; other site
656519005572	Sugar specificity; other site
656519005573	Pyrimidine base specificity; other site
656519005574	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
656519005575	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
656519005576	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
656519005577	active site
656519005578	nucleophile elbow; other site
656519005579	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
656519005580	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519005581	active site
656519005582	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
656519005583	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
656519005584	metal-binding site [ion binding]
656519005585	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
656519005586	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
656519005587	metal-binding site [ion binding]
656519005588	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
656519005589	Soluble P-type ATPase [General function prediction only]; Region: COG4087
656519005590	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
656519005591	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
656519005592	Coenzyme A binding pocket [chemical binding]; other site
656519005593	ornithine carbamoyltransferase; Validated; Region: PRK02102
656519005594	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
656519005595	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
656519005596	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
656519005597	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
656519005598	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
656519005599	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
656519005600	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
656519005601	HIGH motif; other site
656519005602	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
656519005603	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
656519005604	active site
656519005605	KMSKS motif; other site
656519005606	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
656519005607	tRNA binding surface [nucleotide binding]; other site
656519005608	Oligomerisation domain; Region: Oligomerisation; pfam02410
656519005609	Transcriptional regulator [Transcription]; Region: LytR; COG1316
656519005610	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
656519005611	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519005612	Zn2+ binding site [ion binding]; other site
656519005613	Mg2+ binding site [ion binding]; other site
656519005614	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
656519005615	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
656519005616	active site
656519005617	(T/H)XGH motif; other site
656519005618	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
656519005619	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
656519005620	trimer interface [polypeptide binding]; other site
656519005621	putative metal binding site [ion binding]; other site
656519005622	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
656519005623	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
656519005624	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
656519005625	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
656519005626	substrate binding pocket [chemical binding]; other site
656519005627	dimer interface [polypeptide binding]; other site
656519005628	inhibitor binding site; inhibition site
656519005629	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
656519005630	B12 binding site [chemical binding]; other site
656519005631	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
656519005632	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
656519005633	FAD binding site [chemical binding]; other site
656519005634	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
656519005635	metal-binding site [ion binding]
656519005636	Short C-terminal domain; Region: SHOCT; pfam09851
656519005637	Predicted membrane protein [Function unknown]; Region: COG3462
656519005638	Short C-terminal domain; Region: SHOCT; pfam09851
656519005639	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
656519005640	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
656519005641	dimer interface [polypeptide binding]; other site
656519005642	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519005643	catalytic residue [active]
656519005644	Rrf2 family protein; Region: rrf2_super; TIGR00738
656519005645	Transcriptional regulator; Region: Rrf2; pfam02082
656519005646	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
656519005647	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519005648	RNA binding site [nucleotide binding]; other site
656519005649	hypothetical protein; Reviewed; Region: PRK09588
656519005650	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
656519005651	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
656519005652	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
656519005653	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
656519005654	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519005655	putative substrate translocation pore; other site
656519005656	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
656519005657	putative catalytic site [active]
656519005658	putative metal binding site [ion binding]; other site
656519005659	putative phosphate binding site [ion binding]; other site
656519005660	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
656519005661	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
656519005662	Na binding site [ion binding]; other site
656519005663	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
656519005664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519005665	S-adenosylmethionine binding site [chemical binding]; other site
656519005666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
656519005667	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
656519005668	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
656519005669	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
656519005670	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
656519005671	MarR family; Region: MarR; pfam01047
656519005672	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
656519005673	putative FMN binding site [chemical binding]; other site
656519005674	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
656519005675	Na2 binding site [ion binding]; other site
656519005676	putative substrate binding site 1 [chemical binding]; other site
656519005677	Na binding site 1 [ion binding]; other site
656519005678	putative substrate binding site 2 [chemical binding]; other site
656519005679	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
656519005680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519005681	S-adenosylmethionine binding site [chemical binding]; other site
656519005682	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
656519005683	hexamer interface [polypeptide binding]; other site
656519005684	RNA binding site [nucleotide binding]; other site
656519005685	Histidine-zinc binding site [chemical binding]; other site
656519005686	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
656519005687	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
656519005688	zinc binding site [ion binding]; other site
656519005689	putative ligand binding site [chemical binding]; other site
656519005690	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
656519005691	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
656519005692	TM-ABC transporter signature motif; other site
656519005693	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
656519005694	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519005695	Walker A/P-loop; other site
656519005696	ATP binding site [chemical binding]; other site
656519005697	Q-loop/lid; other site
656519005698	ABC transporter signature motif; other site
656519005699	Walker B; other site
656519005700	D-loop; other site
656519005701	H-loop/switch region; other site
656519005702	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
656519005703	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
656519005704	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
656519005705	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
656519005706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005707	dimer interface [polypeptide binding]; other site
656519005708	conserved gate region; other site
656519005709	putative PBP binding loops; other site
656519005710	ABC-ATPase subunit interface; other site
656519005711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005712	dimer interface [polypeptide binding]; other site
656519005713	conserved gate region; other site
656519005714	putative PBP binding loops; other site
656519005715	ABC-ATPase subunit interface; other site
656519005716	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519005717	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
656519005718	Transcriptional regulators [Transcription]; Region: PurR; COG1609
656519005719	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
656519005720	DNA binding site [nucleotide binding]
656519005721	domain linker motif; other site
656519005722	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
656519005723	dimerization interface [polypeptide binding]; other site
656519005724	ligand binding site [chemical binding]; other site
656519005725	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519005726	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
656519005727	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
656519005728	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
656519005729	Walker A/P-loop; other site
656519005730	ATP binding site [chemical binding]; other site
656519005731	Q-loop/lid; other site
656519005732	ABC transporter signature motif; other site
656519005733	Walker B; other site
656519005734	D-loop; other site
656519005735	H-loop/switch region; other site
656519005736	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
656519005737	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
656519005738	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
656519005739	N-acetyl-D-glucosamine binding site [chemical binding]; other site
656519005740	catalytic residue [active]
656519005741	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
656519005742	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
656519005743	CoA-binding site [chemical binding]; other site
656519005744	ATP-binding [chemical binding]; other site
656519005745	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
656519005746	active site
656519005747	dimer interfaces [polypeptide binding]; other site
656519005748	catalytic residues [active]
656519005749	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
656519005750	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
656519005751	DNA binding site [nucleotide binding]
656519005752	catalytic residue [active]
656519005753	H2TH interface [polypeptide binding]; other site
656519005754	putative catalytic residues [active]
656519005755	turnover-facilitating residue; other site
656519005756	intercalation triad [nucleotide binding]; other site
656519005757	8OG recognition residue [nucleotide binding]; other site
656519005758	putative reading head residues; other site
656519005759	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
656519005760	DNA polymerase I; Provisional; Region: PRK05755
656519005761	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
656519005762	active site
656519005763	metal binding site 1 [ion binding]; metal-binding site
656519005764	putative 5' ssDNA interaction site; other site
656519005765	metal binding site 3; metal-binding site
656519005766	metal binding site 2 [ion binding]; metal-binding site
656519005767	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
656519005768	putative DNA binding site [nucleotide binding]; other site
656519005769	putative metal binding site [ion binding]; other site
656519005770	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
656519005771	active site
656519005772	substrate binding site [chemical binding]; other site
656519005773	catalytic site [active]
656519005774	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
656519005775	active site
656519005776	DNA binding site [nucleotide binding]
656519005777	catalytic site [active]
656519005778	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
656519005779	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519005780	dimerization interface [polypeptide binding]; other site
656519005781	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519005782	dimer interface [polypeptide binding]; other site
656519005783	phosphorylation site [posttranslational modification]
656519005784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519005785	ATP binding site [chemical binding]; other site
656519005786	Mg2+ binding site [ion binding]; other site
656519005787	G-X-G motif; other site
656519005788	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
656519005789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519005790	active site
656519005791	phosphorylation site [posttranslational modification]
656519005792	intermolecular recognition site; other site
656519005793	dimerization interface [polypeptide binding]; other site
656519005794	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
656519005795	DNA binding site [nucleotide binding]
656519005796	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
656519005797	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
656519005798	protein binding site [polypeptide binding]; other site
656519005799	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
656519005800	catalytic core [active]
656519005801	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
656519005802	Domain of unknown function (DUF368); Region: DUF368; pfam04018
656519005803	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519005804	active site
656519005805	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
656519005806	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
656519005807	heterodimer interface [polypeptide binding]; other site
656519005808	active site
656519005809	FMN binding site [chemical binding]; other site
656519005810	homodimer interface [polypeptide binding]; other site
656519005811	substrate binding site [chemical binding]; other site
656519005812	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
656519005813	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
656519005814	FAD binding pocket [chemical binding]; other site
656519005815	FAD binding motif [chemical binding]; other site
656519005816	phosphate binding motif [ion binding]; other site
656519005817	beta-alpha-beta structure motif; other site
656519005818	NAD binding pocket [chemical binding]; other site
656519005819	Iron coordination center [ion binding]; other site
656519005820	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
656519005821	active site
656519005822	dimer interface [polypeptide binding]; other site
656519005823	dihydroorotase; Validated; Region: pyrC; PRK09357
656519005824	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519005825	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
656519005826	active site
656519005827	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
656519005828	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
656519005829	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
656519005830	uracil-xanthine permease; Region: ncs2; TIGR00801
656519005831	Sulfate transporter family; Region: Sulfate_transp; pfam00916
656519005832	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
656519005833	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519005834	active site
656519005835	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
656519005836	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519005837	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
656519005838	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
656519005839	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
656519005840	ATP-grasp domain; Region: ATP-grasp_4; cl17255
656519005841	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
656519005842	IMP binding site; other site
656519005843	dimer interface [polypeptide binding]; other site
656519005844	interdomain contacts; other site
656519005845	partial ornithine binding site; other site
656519005846	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
656519005847	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
656519005848	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
656519005849	catalytic site [active]
656519005850	subunit interface [polypeptide binding]; other site
656519005851	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
656519005852	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
656519005853	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
656519005854	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
656519005855	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
656519005856	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
656519005857	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
656519005858	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
656519005859	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
656519005860	putative dimer interface [polypeptide binding]; other site
656519005861	[2Fe-2S] cluster binding site [ion binding]; other site
656519005862	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519005863	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519005864	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
656519005865	Putative Fe-S cluster; Region: FeS; cl17515
656519005866	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519005867	PAS domain; Region: PAS_9; pfam13426
656519005868	putative active site [active]
656519005869	heme pocket [chemical binding]; other site
656519005870	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
656519005871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519005872	Walker A motif; other site
656519005873	ATP binding site [chemical binding]; other site
656519005874	Walker B motif; other site
656519005875	arginine finger; other site
656519005876	Predicted permease; Region: DUF318; cl17795
656519005877	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
656519005878	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519005879	catalytic residue [active]
656519005880	EDD domain protein, DegV family; Region: DegV; TIGR00762
656519005881	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
656519005882	Integrase core domain; Region: rve; pfam00665
656519005883	DDE domain; Region: DDE_Tnp_IS240; pfam13610
656519005884	Integrase core domain; Region: rve_3; cl15866
656519005885	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
656519005886	DNA-binding site [nucleotide binding]; DNA binding site
656519005887	RNA-binding motif; other site
656519005888	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00197
656519005889	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
656519005890	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
656519005891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005892	dimer interface [polypeptide binding]; other site
656519005893	conserved gate region; other site
656519005894	ABC-ATPase subunit interface; other site
656519005895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519005896	dimer interface [polypeptide binding]; other site
656519005897	conserved gate region; other site
656519005898	ABC-ATPase subunit interface; other site
656519005899	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
656519005900	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
656519005901	Walker A/P-loop; other site
656519005902	ATP binding site [chemical binding]; other site
656519005903	Q-loop/lid; other site
656519005904	ABC transporter signature motif; other site
656519005905	Walker B; other site
656519005906	D-loop; other site
656519005907	H-loop/switch region; other site
656519005908	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
656519005909	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
656519005910	tetramer interfaces [polypeptide binding]; other site
656519005911	binuclear metal-binding site [ion binding]; other site
656519005912	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
656519005913	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
656519005914	Coenzyme A binding pocket [chemical binding]; other site
656519005915	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
656519005916	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519005917	catalytic residue [active]
656519005918	Transposase; Region: HTH_Tnp_1; pfam01527
656519005919	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519005920	putative transposase OrfB; Reviewed; Region: PHA02517
656519005921	HTH-like domain; Region: HTH_21; pfam13276
656519005922	Integrase core domain; Region: rve; pfam00665
656519005923	Integrase core domain; Region: rve_3; pfam13683
656519005924	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519005925	PAS domain; Region: PAS_9; pfam13426
656519005926	putative active site [active]
656519005927	heme pocket [chemical binding]; other site
656519005928	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519005929	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519005930	metal binding site [ion binding]; metal-binding site
656519005931	active site
656519005932	I-site; other site
656519005933	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519005934	Zn2+ binding site [ion binding]; other site
656519005935	Mg2+ binding site [ion binding]; other site
656519005936	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519005937	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519005938	Integrase core domain; Region: rve; pfam00665
656519005939	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519005940	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519005941	Integrase core domain; Region: rve; pfam00665
656519005942	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
656519005943	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519005944	DNA-binding site [nucleotide binding]; DNA binding site
656519005945	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
656519005946	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519005947	MULE transposase domain; Region: MULE; pfam10551
656519005948	Transposase; Region: DDE_Tnp_ISL3; pfam01610
656519005949	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
656519005950	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
656519005951	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
656519005952	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
656519005953	homodimer interface [polypeptide binding]; other site
656519005954	NADP binding site [chemical binding]; other site
656519005955	substrate binding site [chemical binding]; other site
656519005956	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
656519005957	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
656519005958	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
656519005959	Curlin associated repeat; Region: Curlin_rpt; pfam07012
656519005960	Curlin associated repeat; Region: Curlin_rpt; pfam07012
656519005961	Curlin associated repeat; Region: Curlin_rpt; pfam07012
656519005962	Curlin associated repeat; Region: Curlin_rpt; pfam07012
656519005963	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
656519005964	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
656519005965	Bacterial transcriptional activator domain; Region: BTAD; smart01043
656519005966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
656519005967	TPR motif; other site
656519005968	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519005969	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
656519005970	active site
656519005971	NAD binding site [chemical binding]; other site
656519005972	metal binding site [ion binding]; metal-binding site
656519005973	hypothetical protein; Provisional; Region: PRK13690
656519005974	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
656519005975	putative hydrolase; Validated; Region: PRK09248
656519005976	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
656519005977	active site
656519005978	pyruvate kinase; Provisional; Region: PRK06354
656519005979	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
656519005980	domain interfaces; other site
656519005981	active site
656519005982	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
656519005983	6-phosphofructokinase; Provisional; Region: PRK03202
656519005984	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
656519005985	active site
656519005986	ADP/pyrophosphate binding site [chemical binding]; other site
656519005987	dimerization interface [polypeptide binding]; other site
656519005988	allosteric effector site; other site
656519005989	fructose-1,6-bisphosphate binding site; other site
656519005990	transcription attenuation protein MtrB; Provisional; Region: PRK13251
656519005991	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
656519005992	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
656519005993	active site
656519005994	PHP Thumb interface [polypeptide binding]; other site
656519005995	metal binding site [ion binding]; metal-binding site
656519005996	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
656519005997	generic binding surface I; other site
656519005998	generic binding surface II; other site
656519005999	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
656519006000	Protein of unknown function (DUF964); Region: DUF964; cl01483
656519006001	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
656519006002	active site
656519006003	metal binding site [ion binding]; metal-binding site
656519006004	homotetramer interface [polypeptide binding]; other site
656519006005	Uncharacterized conserved protein [Function unknown]; Region: COG2006
656519006006	Domain of unknown function (DUF362); Region: DUF362; pfam04015
656519006007	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
656519006008	TRAM domain; Region: TRAM; pfam01938
656519006009	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
656519006010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519006011	S-adenosylmethionine binding site [chemical binding]; other site
656519006012	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
656519006013	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
656519006014	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
656519006015	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519006016	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519006017	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
656519006018	active site residue [active]
656519006019	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519006020	dimerization interface [polypeptide binding]; other site
656519006021	putative DNA binding site [nucleotide binding]; other site
656519006022	putative Zn2+ binding site [ion binding]; other site
656519006023	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
656519006024	putative active site [active]
656519006025	putative CoA binding site [chemical binding]; other site
656519006026	nudix motif; other site
656519006027	metal binding site [ion binding]; metal-binding site
656519006028	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
656519006029	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
656519006030	GatB domain; Region: GatB_Yqey; smart00845
656519006031	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
656519006032	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
656519006033	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
656519006034	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
656519006035	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
656519006036	nucleotide binding pocket [chemical binding]; other site
656519006037	K-X-D-G motif; other site
656519006038	catalytic site [active]
656519006039	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
656519006040	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
656519006041	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
656519006042	Dimer interface [polypeptide binding]; other site
656519006043	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
656519006044	Part of AAA domain; Region: AAA_19; pfam13245
656519006045	Family description; Region: UvrD_C_2; pfam13538
656519006046	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
656519006047	GIY-YIG motif/motif A; other site
656519006048	putative active site [active]
656519006049	putative metal binding site [ion binding]; other site
656519006050	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
656519006051	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
656519006052	HflX GTPase family; Region: HflX; cd01878
656519006053	G1 box; other site
656519006054	GTP/Mg2+ binding site [chemical binding]; other site
656519006055	Switch I region; other site
656519006056	G2 box; other site
656519006057	G3 box; other site
656519006058	Switch II region; other site
656519006059	G4 box; other site
656519006060	G5 box; other site
656519006061	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
656519006062	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
656519006063	dimerization interface [polypeptide binding]; other site
656519006064	domain crossover interface; other site
656519006065	redox-dependent activation switch; other site
656519006066	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
656519006067	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
656519006068	DHH family; Region: DHH; pfam01368
656519006069	DHHA1 domain; Region: DHHA1; pfam02272
656519006070	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
656519006071	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
656519006072	Part of AAA domain; Region: AAA_19; pfam13245
656519006073	Family description; Region: UvrD_C_2; pfam13538
656519006074	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
656519006075	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
656519006076	Protein of unknown function (DUF456); Region: DUF456; pfam04306
656519006077	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
656519006078	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
656519006079	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
656519006080	hydroxyglutarate oxidase; Provisional; Region: PRK11728
656519006081	Trp repressor protein; Region: Trp_repressor; cl17266
656519006082	GMP synthase; Reviewed; Region: guaA; PRK00074
656519006083	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
656519006084	AMP/PPi binding site [chemical binding]; other site
656519006085	candidate oxyanion hole; other site
656519006086	catalytic triad [active]
656519006087	potential glutamine specificity residues [chemical binding]; other site
656519006088	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
656519006089	ATP Binding subdomain [chemical binding]; other site
656519006090	Ligand Binding sites [chemical binding]; other site
656519006091	Dimerization subdomain; other site
656519006092	pyruvate phosphate dikinase; Provisional; Region: PRK09279
656519006093	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
656519006094	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
656519006095	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
656519006096	PEP synthetase regulatory protein; Provisional; Region: PRK05339
656519006097	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
656519006098	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
656519006099	ring oligomerisation interface [polypeptide binding]; other site
656519006100	ATP/Mg binding site [chemical binding]; other site
656519006101	stacking interactions; other site
656519006102	hinge regions; other site
656519006103	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
656519006104	oligomerisation interface [polypeptide binding]; other site
656519006105	mobile loop; other site
656519006106	roof hairpin; other site
656519006107	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519006108	Radical SAM superfamily; Region: Radical_SAM; pfam04055
656519006109	FeS/SAM binding site; other site
656519006110	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
656519006111	Protein of unknown function (DUF512); Region: DUF512; pfam04459
656519006112	UGMP family protein; Validated; Region: PRK09604
656519006113	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
656519006114	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
656519006115	Glycoprotease family; Region: Peptidase_M22; pfam00814
656519006116	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
656519006117	pyrroline-5-carboxylate reductase; Region: PLN02688
656519006118	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
656519006119	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
656519006120	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
656519006121	putative catalytic cysteine [active]
656519006122	gamma-glutamyl kinase; Provisional; Region: PRK05429
656519006123	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
656519006124	nucleotide binding site [chemical binding]; other site
656519006125	homotetrameric interface [polypeptide binding]; other site
656519006126	putative phosphate binding site [ion binding]; other site
656519006127	putative allosteric binding site; other site
656519006128	PUA domain; Region: PUA; pfam01472
656519006129	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
656519006130	HPr interaction site; other site
656519006131	glycerol kinase (GK) interaction site [polypeptide binding]; other site
656519006132	active site
656519006133	phosphorylation site [posttranslational modification]
656519006134	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
656519006135	catalytic loop [active]
656519006136	iron binding site [ion binding]; other site
656519006137	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
656519006138	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
656519006139	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
656519006140	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
656519006141	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
656519006142	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
656519006143	dimer interface [polypeptide binding]; other site
656519006144	[2Fe-2S] cluster binding site [ion binding]; other site
656519006145	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
656519006146	SLBB domain; Region: SLBB; pfam10531
656519006147	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
656519006148	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
656519006149	4Fe-4S binding domain; Region: Fer4; pfam00037
656519006150	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519006151	4Fe-4S binding domain; Region: Fer4; pfam00037
656519006152	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
656519006153	dimer interface [polypeptide binding]; other site
656519006154	[2Fe-2S] cluster binding site [ion binding]; other site
656519006155	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
656519006156	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519006157	ATP binding site [chemical binding]; other site
656519006158	Mg2+ binding site [ion binding]; other site
656519006159	G-X-G motif; other site
656519006160	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
656519006161	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
656519006162	putative dimer interface [polypeptide binding]; other site
656519006163	[2Fe-2S] cluster binding site [ion binding]; other site
656519006164	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
656519006165	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
656519006166	active site
656519006167	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
656519006168	PHP-associated; Region: PHP_C; pfam13263
656519006169	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
656519006170	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519006171	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
656519006172	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
656519006173	Putative Fe-S cluster; Region: FeS; cl17515
656519006174	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
656519006175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519006176	ATP binding site [chemical binding]; other site
656519006177	G-X-G motif; other site
656519006178	PemK-like protein; Region: PemK; pfam02452
656519006179	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
656519006180	RNA binding site [nucleotide binding]; other site
656519006181	DNA helicase, putative; Region: TIGR00376
656519006182	Part of AAA domain; Region: AAA_19; pfam13245
656519006183	AAA domain; Region: AAA_12; pfam13087
656519006184	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
656519006185	trimer interface [polypeptide binding]; other site
656519006186	active site
656519006187	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
656519006188	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
656519006189	putative substrate binding site [chemical binding]; other site
656519006190	putative ATP binding site [chemical binding]; other site
656519006191	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
656519006192	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
656519006193	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
656519006194	glutaminase active site [active]
656519006195	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
656519006196	dimer interface [polypeptide binding]; other site
656519006197	active site
656519006198	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
656519006199	dimer interface [polypeptide binding]; other site
656519006200	active site
656519006201	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
656519006202	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
656519006203	active site
656519006204	substrate binding site [chemical binding]; other site
656519006205	metal binding site [ion binding]; metal-binding site
656519006206	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
656519006207	TIGR00159 family protein; Region: TIGR00159
656519006208	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
656519006209	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
656519006210	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519006211	FeS/SAM binding site; other site
656519006212	AMMECR1; Region: AMMECR1; pfam01871
656519006213	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
656519006214	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
656519006215	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
656519006216	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
656519006217	23S rRNA interface [nucleotide binding]; other site
656519006218	L3 interface [polypeptide binding]; other site
656519006219	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
656519006220	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
656519006221	dimerization interface 3.5A [polypeptide binding]; other site
656519006222	active site
656519006223	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
656519006224	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
656519006225	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
656519006226	Walker A/P-loop; other site
656519006227	ATP binding site [chemical binding]; other site
656519006228	Q-loop/lid; other site
656519006229	ABC transporter signature motif; other site
656519006230	Walker B; other site
656519006231	D-loop; other site
656519006232	H-loop/switch region; other site
656519006233	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
656519006234	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
656519006235	Walker A/P-loop; other site
656519006236	ATP binding site [chemical binding]; other site
656519006237	Q-loop/lid; other site
656519006238	ABC transporter signature motif; other site
656519006239	Walker B; other site
656519006240	D-loop; other site
656519006241	H-loop/switch region; other site
656519006242	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
656519006243	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
656519006244	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
656519006245	alphaNTD homodimer interface [polypeptide binding]; other site
656519006246	alphaNTD - beta interaction site [polypeptide binding]; other site
656519006247	alphaNTD - beta' interaction site [polypeptide binding]; other site
656519006248	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
656519006249	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
656519006250	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
656519006251	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
656519006252	RNA binding surface [nucleotide binding]; other site
656519006253	30S ribosomal protein S11; Validated; Region: PRK05309
656519006254	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
656519006255	30S ribosomal protein S13; Region: bact_S13; TIGR03631
656519006256	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
656519006257	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
656519006258	rRNA binding site [nucleotide binding]; other site
656519006259	predicted 30S ribosome binding site; other site
656519006260	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
656519006261	active site
656519006262	adenylate kinase; Reviewed; Region: adk; PRK00279
656519006263	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
656519006264	AMP-binding site [chemical binding]; other site
656519006265	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
656519006266	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
656519006267	SecY translocase; Region: SecY; pfam00344
656519006268	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
656519006269	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
656519006270	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
656519006271	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
656519006272	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
656519006273	23S rRNA interface [nucleotide binding]; other site
656519006274	L21e interface [polypeptide binding]; other site
656519006275	5S rRNA interface [nucleotide binding]; other site
656519006276	L27 interface [polypeptide binding]; other site
656519006277	L5 interface [polypeptide binding]; other site
656519006278	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
656519006279	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
656519006280	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
656519006281	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
656519006282	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
656519006283	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
656519006284	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
656519006285	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
656519006286	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
656519006287	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
656519006288	RNA binding site [nucleotide binding]; other site
656519006289	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
656519006290	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
656519006291	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
656519006292	putative translocon interaction site; other site
656519006293	23S rRNA interface [nucleotide binding]; other site
656519006294	signal recognition particle (SRP54) interaction site; other site
656519006295	L23 interface [polypeptide binding]; other site
656519006296	trigger factor interaction site; other site
656519006297	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
656519006298	23S rRNA interface [nucleotide binding]; other site
656519006299	5S rRNA interface [nucleotide binding]; other site
656519006300	putative antibiotic binding site [chemical binding]; other site
656519006301	L25 interface [polypeptide binding]; other site
656519006302	L27 interface [polypeptide binding]; other site
656519006303	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
656519006304	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
656519006305	G-X-X-G motif; other site
656519006306	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
656519006307	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
656519006308	putative translocon binding site; other site
656519006309	protein-rRNA interface [nucleotide binding]; other site
656519006310	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
656519006311	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
656519006312	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
656519006313	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
656519006314	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
656519006315	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
656519006316	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
656519006317	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
656519006318	elongation factor Tu; Reviewed; Region: PRK00049
656519006319	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
656519006320	G1 box; other site
656519006321	GEF interaction site [polypeptide binding]; other site
656519006322	GTP/Mg2+ binding site [chemical binding]; other site
656519006323	Switch I region; other site
656519006324	G2 box; other site
656519006325	G3 box; other site
656519006326	Switch II region; other site
656519006327	G4 box; other site
656519006328	G5 box; other site
656519006329	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
656519006330	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
656519006331	Antibiotic Binding Site [chemical binding]; other site
656519006332	elongation factor G; Reviewed; Region: PRK00007
656519006333	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
656519006334	G1 box; other site
656519006335	putative GEF interaction site [polypeptide binding]; other site
656519006336	GTP/Mg2+ binding site [chemical binding]; other site
656519006337	Switch I region; other site
656519006338	G2 box; other site
656519006339	G3 box; other site
656519006340	Switch II region; other site
656519006341	G4 box; other site
656519006342	G5 box; other site
656519006343	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
656519006344	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
656519006345	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
656519006346	30S ribosomal protein S7; Validated; Region: PRK05302
656519006347	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
656519006348	S17 interaction site [polypeptide binding]; other site
656519006349	S8 interaction site; other site
656519006350	16S rRNA interaction site [nucleotide binding]; other site
656519006351	streptomycin interaction site [chemical binding]; other site
656519006352	23S rRNA interaction site [nucleotide binding]; other site
656519006353	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
656519006354	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
656519006355	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
656519006356	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
656519006357	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
656519006358	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
656519006359	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
656519006360	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
656519006361	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
656519006362	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
656519006363	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
656519006364	DNA binding site [nucleotide binding]
656519006365	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
656519006366	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
656519006367	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
656519006368	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
656519006369	RPB1 interaction site [polypeptide binding]; other site
656519006370	RPB10 interaction site [polypeptide binding]; other site
656519006371	RPB11 interaction site [polypeptide binding]; other site
656519006372	RPB3 interaction site [polypeptide binding]; other site
656519006373	RPB12 interaction site [polypeptide binding]; other site
656519006374	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
656519006375	L11 interface [polypeptide binding]; other site
656519006376	putative EF-Tu interaction site [polypeptide binding]; other site
656519006377	putative EF-G interaction site [polypeptide binding]; other site
656519006378	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
656519006379	23S rRNA interface [nucleotide binding]; other site
656519006380	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
656519006381	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
656519006382	mRNA/rRNA interface [nucleotide binding]; other site
656519006383	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
656519006384	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
656519006385	23S rRNA interface [nucleotide binding]; other site
656519006386	L7/L12 interface [polypeptide binding]; other site
656519006387	putative thiostrepton binding site; other site
656519006388	L25 interface [polypeptide binding]; other site
656519006389	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
656519006390	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
656519006391	putative homodimer interface [polypeptide binding]; other site
656519006392	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
656519006393	heterodimer interface [polypeptide binding]; other site
656519006394	homodimer interface [polypeptide binding]; other site
656519006395	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
656519006396	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
656519006397	elongation factor Tu; Reviewed; Region: PRK00049
656519006398	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
656519006399	G1 box; other site
656519006400	GEF interaction site [polypeptide binding]; other site
656519006401	GTP/Mg2+ binding site [chemical binding]; other site
656519006402	Switch I region; other site
656519006403	G2 box; other site
656519006404	G3 box; other site
656519006405	Switch II region; other site
656519006406	G4 box; other site
656519006407	G5 box; other site
656519006408	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
656519006409	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
656519006410	Antibiotic Binding Site [chemical binding]; other site
656519006411	RNA polymerase factor sigma-70; Validated; Region: PRK08295
656519006412	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
656519006413	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
656519006414	DNA binding residues [nucleotide binding]
656519006415	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
656519006416	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
656519006417	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
656519006418	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
656519006419	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
656519006420	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
656519006421	active site
656519006422	HIGH motif; other site
656519006423	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
656519006424	KMSKS motif; other site
656519006425	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
656519006426	tRNA binding surface [nucleotide binding]; other site
656519006427	anticodon binding site; other site
656519006428	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
656519006429	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
656519006430	active site
656519006431	HIGH motif; other site
656519006432	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
656519006433	active site
656519006434	KMSKS motif; other site
656519006435	FOG: CBS domain [General function prediction only]; Region: COG0517
656519006436	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
656519006437	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
656519006438	hexamer interface [polypeptide binding]; other site
656519006439	RNA binding site [nucleotide binding]; other site
656519006440	Histidine-zinc binding site [chemical binding]; other site
656519006441	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
656519006442	homotrimer interaction site [polypeptide binding]; other site
656519006443	zinc binding site [ion binding]; other site
656519006444	CDP-binding sites; other site
656519006445	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
656519006446	substrate binding site; other site
656519006447	dimer interface; other site
656519006448	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
656519006449	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
656519006450	putative active site [active]
656519006451	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
656519006452	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
656519006453	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
656519006454	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
656519006455	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
656519006456	Clp amino terminal domain; Region: Clp_N; pfam02861
656519006457	Clp amino terminal domain; Region: Clp_N; pfam02861
656519006458	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519006459	Walker A motif; other site
656519006460	ATP binding site [chemical binding]; other site
656519006461	Walker B motif; other site
656519006462	arginine finger; other site
656519006463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519006464	Walker A motif; other site
656519006465	ATP binding site [chemical binding]; other site
656519006466	Walker B motif; other site
656519006467	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
656519006468	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
656519006469	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
656519006470	ADP binding site [chemical binding]; other site
656519006471	phosphagen binding site; other site
656519006472	substrate specificity loop; other site
656519006473	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
656519006474	UvrB/uvrC motif; Region: UVR; pfam02151
656519006475	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
656519006476	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
656519006477	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
656519006478	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
656519006479	dimer interface [polypeptide binding]; other site
656519006480	putative anticodon binding site; other site
656519006481	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
656519006482	motif 1; other site
656519006483	active site
656519006484	motif 2; other site
656519006485	motif 3; other site
656519006486	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
656519006487	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
656519006488	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
656519006489	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
656519006490	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
656519006491	FMN binding site [chemical binding]; other site
656519006492	active site
656519006493	catalytic residues [active]
656519006494	substrate binding site [chemical binding]; other site
656519006495	pantothenate kinase; Reviewed; Region: PRK13318
656519006496	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
656519006497	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
656519006498	FMN binding site [chemical binding]; other site
656519006499	substrate binding site [chemical binding]; other site
656519006500	putative catalytic residue [active]
656519006501	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
656519006502	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
656519006503	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
656519006504	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
656519006505	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
656519006506	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
656519006507	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
656519006508	Potassium binding sites [ion binding]; other site
656519006509	Cesium cation binding sites [ion binding]; other site
656519006510	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
656519006511	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
656519006512	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
656519006513	Walker A/P-loop; other site
656519006514	ATP binding site [chemical binding]; other site
656519006515	Q-loop/lid; other site
656519006516	ABC transporter signature motif; other site
656519006517	Walker B; other site
656519006518	D-loop; other site
656519006519	H-loop/switch region; other site
656519006520	FtsH Extracellular; Region: FtsH_ext; pfam06480
656519006521	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
656519006522	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519006523	Walker A motif; other site
656519006524	ATP binding site [chemical binding]; other site
656519006525	Walker B motif; other site
656519006526	arginine finger; other site
656519006527	Peptidase family M41; Region: Peptidase_M41; pfam01434
656519006528	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519006529	active site
656519006530	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
656519006531	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
656519006532	Ligand Binding Site [chemical binding]; other site
656519006533	TilS substrate C-terminal domain; Region: TilS_C; smart00977
656519006534	exopolyphosphatase; Region: exo_poly_only; TIGR03706
656519006535	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
656519006536	Protein of unknown function (DUF501); Region: DUF501; pfam04417
656519006537	hypothetical protein; Provisional; Region: PRK08582
656519006538	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
656519006539	RNA binding site [nucleotide binding]; other site
656519006540	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519006541	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519006542	Integrase core domain; Region: rve; pfam00665
656519006543	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
656519006544	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
656519006545	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
656519006546	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
656519006547	RNA binding site [nucleotide binding]; other site
656519006548	Septum formation initiator; Region: DivIC; pfam04977
656519006549	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
656519006550	Protein of unknown function (DUF964); Region: DUF964; pfam06133
656519006551	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
656519006552	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
656519006553	P loop; other site
656519006554	Nucleotide binding site [chemical binding]; other site
656519006555	DTAP/Switch II; other site
656519006556	Switch I; other site
656519006557	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
656519006558	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
656519006559	P loop; other site
656519006560	Nucleotide binding site [chemical binding]; other site
656519006561	DTAP/Switch II; other site
656519006562	Switch I; other site
656519006563	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
656519006564	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519006565	dimerization interface [polypeptide binding]; other site
656519006566	putative DNA binding site [nucleotide binding]; other site
656519006567	putative Zn2+ binding site [ion binding]; other site
656519006568	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
656519006569	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
656519006570	catalytic triad [active]
656519006571	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
656519006572	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
656519006573	Walker A/P-loop; other site
656519006574	ATP binding site [chemical binding]; other site
656519006575	Q-loop/lid; other site
656519006576	ABC transporter signature motif; other site
656519006577	Walker B; other site
656519006578	D-loop; other site
656519006579	H-loop/switch region; other site
656519006580	TOBE domain; Region: TOBE; pfam03459
656519006581	Transcriptional regulators [Transcription]; Region: PurR; COG1609
656519006582	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
656519006583	DNA binding site [nucleotide binding]
656519006584	domain linker motif; other site
656519006585	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
656519006586	dimerization interface [polypeptide binding]; other site
656519006587	ligand binding site [chemical binding]; other site
656519006588	beta-phosphoglucomutase; Region: bPGM; TIGR01990
656519006589	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519006590	motif II; other site
656519006591	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
656519006592	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
656519006593	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
656519006594	Walker A/P-loop; other site
656519006595	ATP binding site [chemical binding]; other site
656519006596	Q-loop/lid; other site
656519006597	ABC transporter signature motif; other site
656519006598	Walker B; other site
656519006599	D-loop; other site
656519006600	H-loop/switch region; other site
656519006601	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
656519006602	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519006603	ABC-ATPase subunit  interface; other site
656519006604	dimer interface [polypeptide binding]; other site
656519006605	putative PBP binding regions; other site
656519006606	Uncharacterized conserved protein [Function unknown]; Region: COG4198
656519006607	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
656519006608	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
656519006609	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
656519006610	ligand binding site [chemical binding]; other site
656519006611	NAD binding site [chemical binding]; other site
656519006612	dimerization interface [polypeptide binding]; other site
656519006613	catalytic site [active]
656519006614	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
656519006615	putative L-serine binding site [chemical binding]; other site
656519006616	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
656519006617	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519006618	catalytic residue [active]
656519006619	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
656519006620	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
656519006621	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
656519006622	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
656519006623	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
656519006624	homodimer interface [polypeptide binding]; other site
656519006625	metal binding site [ion binding]; metal-binding site
656519006626	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
656519006627	homodimer interface [polypeptide binding]; other site
656519006628	active site
656519006629	putative chemical substrate binding site [chemical binding]; other site
656519006630	metal binding site [ion binding]; metal-binding site
656519006631	stage V sporulation protein B; Region: spore_V_B; TIGR02900
656519006632	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
656519006633	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
656519006634	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
656519006635	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
656519006636	ATP binding site [chemical binding]; other site
656519006637	putative Mg++ binding site [ion binding]; other site
656519006638	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
656519006639	nucleotide binding region [chemical binding]; other site
656519006640	ATP-binding site [chemical binding]; other site
656519006641	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
656519006642	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
656519006643	putative active site [active]
656519006644	catalytic residue [active]
656519006645	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
656519006646	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
656519006647	5S rRNA interface [nucleotide binding]; other site
656519006648	CTC domain interface [polypeptide binding]; other site
656519006649	L16 interface [polypeptide binding]; other site
656519006650	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
656519006651	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
656519006652	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519006653	active site
656519006654	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
656519006655	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
656519006656	Substrate binding site; other site
656519006657	Mg++ binding site; other site
656519006658	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
656519006659	active site
656519006660	substrate binding site [chemical binding]; other site
656519006661	CoA binding site [chemical binding]; other site
656519006662	SpoVG; Region: SpoVG; pfam04026
656519006663	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
656519006664	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
656519006665	dimerization interface [polypeptide binding]; other site
656519006666	putative ATP binding site [chemical binding]; other site
656519006667	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
656519006668	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
656519006669	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
656519006670	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
656519006671	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
656519006672	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
656519006673	DNA binding residues [nucleotide binding]
656519006674	putative dimer interface [polypeptide binding]; other site
656519006675	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
656519006676	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
656519006677	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
656519006678	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
656519006679	PspC domain; Region: PspC; pfam04024
656519006680	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519006681	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
656519006682	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
656519006683	Walker A/P-loop; other site
656519006684	ATP binding site [chemical binding]; other site
656519006685	Q-loop/lid; other site
656519006686	ABC transporter signature motif; other site
656519006687	Walker B; other site
656519006688	D-loop; other site
656519006689	H-loop/switch region; other site
656519006690	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
656519006691	PhoU domain; Region: PhoU; pfam01895
656519006692	PhoU domain; Region: PhoU; pfam01895
656519006693	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
656519006694	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
656519006695	Walker A/P-loop; other site
656519006696	ATP binding site [chemical binding]; other site
656519006697	Q-loop/lid; other site
656519006698	ABC transporter signature motif; other site
656519006699	Walker B; other site
656519006700	D-loop; other site
656519006701	H-loop/switch region; other site
656519006702	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
656519006703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006704	dimer interface [polypeptide binding]; other site
656519006705	conserved gate region; other site
656519006706	putative PBP binding loops; other site
656519006707	ABC-ATPase subunit interface; other site
656519006708	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
656519006709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006710	dimer interface [polypeptide binding]; other site
656519006711	conserved gate region; other site
656519006712	putative PBP binding loops; other site
656519006713	ABC-ATPase subunit interface; other site
656519006714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
656519006715	PBP superfamily domain; Region: PBP_like_2; cl17296
656519006716	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
656519006717	dimerization interface [polypeptide binding]; other site
656519006718	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
656519006719	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519006720	putative active site [active]
656519006721	heme pocket [chemical binding]; other site
656519006722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519006723	dimer interface [polypeptide binding]; other site
656519006724	phosphorylation site [posttranslational modification]
656519006725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519006726	ATP binding site [chemical binding]; other site
656519006727	Mg2+ binding site [ion binding]; other site
656519006728	G-X-G motif; other site
656519006729	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
656519006730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519006731	active site
656519006732	phosphorylation site [posttranslational modification]
656519006733	intermolecular recognition site; other site
656519006734	dimerization interface [polypeptide binding]; other site
656519006735	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
656519006736	DNA binding site [nucleotide binding]
656519006737	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
656519006738	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
656519006739	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
656519006740	PhoU domain; Region: PhoU; pfam01895
656519006741	PhoU domain; Region: PhoU; pfam01895
656519006742	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
656519006743	Protein of unknown function (DUF458); Region: DUF458; pfam04308
656519006744	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
656519006745	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
656519006746	S-adenosylmethionine binding site [chemical binding]; other site
656519006747	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
656519006748	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
656519006749	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
656519006750	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
656519006751	active site
656519006752	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
656519006753	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
656519006754	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519006755	catalytic residue [active]
656519006756	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
656519006757	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
656519006758	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
656519006759	Ligand Binding Site [chemical binding]; other site
656519006760	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
656519006761	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
656519006762	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
656519006763	dimerization interface [polypeptide binding]; other site
656519006764	ATP binding site [chemical binding]; other site
656519006765	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
656519006766	dimerization interface [polypeptide binding]; other site
656519006767	ATP binding site [chemical binding]; other site
656519006768	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
656519006769	putative active site [active]
656519006770	catalytic triad [active]
656519006771	Transcriptional regulator [Transcription]; Region: LysR; COG0583
656519006772	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
656519006773	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
656519006774	dimerization interface [polypeptide binding]; other site
656519006775	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
656519006776	ParB-like nuclease domain; Region: ParB; smart00470
656519006777	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
656519006778	FAD binding domain; Region: FAD_binding_4; pfam01565
656519006779	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
656519006780	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
656519006781	GIY-YIG motif/motif A; other site
656519006782	putative active site [active]
656519006783	putative metal binding site [ion binding]; other site
656519006784	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
656519006785	diiron binding motif [ion binding]; other site
656519006786	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519006787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
656519006788	S-layer homology domain; Region: SLH; pfam00395
656519006789	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
656519006790	Uncharacterized conserved protein [Function unknown]; Region: COG3339
656519006791	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
656519006792	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
656519006793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006794	dimer interface [polypeptide binding]; other site
656519006795	conserved gate region; other site
656519006796	ABC-ATPase subunit interface; other site
656519006797	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
656519006798	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
656519006799	Walker A/P-loop; other site
656519006800	ATP binding site [chemical binding]; other site
656519006801	Q-loop/lid; other site
656519006802	ABC transporter signature motif; other site
656519006803	Walker B; other site
656519006804	D-loop; other site
656519006805	H-loop/switch region; other site
656519006806	NIL domain; Region: NIL; pfam09383
656519006807	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
656519006808	dimerization interface [polypeptide binding]; other site
656519006809	putative DNA binding site [nucleotide binding]; other site
656519006810	putative Zn2+ binding site [ion binding]; other site
656519006811	Predicted permeases [General function prediction only]; Region: COG0701
656519006812	Predicted permease; Region: DUF318; cl17795
656519006813	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
656519006814	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
656519006815	G1 box; other site
656519006816	GTP/Mg2+ binding site [chemical binding]; other site
656519006817	G2 box; other site
656519006818	Switch I region; other site
656519006819	G3 box; other site
656519006820	Switch II region; other site
656519006821	G4 box; other site
656519006822	G5 box; other site
656519006823	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
656519006824	Nucleoside recognition; Region: Gate; pfam07670
656519006825	Nucleoside recognition; Region: Gate; pfam07670
656519006826	FeoA domain; Region: FeoA; pfam04023
656519006827	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
656519006828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
656519006829	S-adenosylmethionine binding site [chemical binding]; other site
656519006830	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519006831	S-adenosylmethionine binding site [chemical binding]; other site
656519006832	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
656519006833	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
656519006834	substrate binding site [chemical binding]; other site
656519006835	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
656519006836	substrate binding site [chemical binding]; other site
656519006837	ligand binding site [chemical binding]; other site
656519006838	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
656519006839	tartrate dehydrogenase; Region: TTC; TIGR02089
656519006840	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
656519006841	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
656519006842	active site
656519006843	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
656519006844	Uncharacterized conserved protein [Function unknown]; Region: COG1434
656519006845	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
656519006846	putative active site [active]
656519006847	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
656519006848	putative homotetramer interface [polypeptide binding]; other site
656519006849	putative homodimer interface [polypeptide binding]; other site
656519006850	putative allosteric switch controlling residues; other site
656519006851	putative metal binding site [ion binding]; other site
656519006852	putative homodimer-homodimer interface [polypeptide binding]; other site
656519006853	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
656519006854	Phosphotransferase enzyme family; Region: APH; pfam01636
656519006855	active site
656519006856	substrate binding site [chemical binding]; other site
656519006857	ATP binding site [chemical binding]; other site
656519006858	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
656519006859	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
656519006860	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
656519006861	Probable Catalytic site; other site
656519006862	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519006863	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
656519006864	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
656519006865	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
656519006866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006867	dimer interface [polypeptide binding]; other site
656519006868	conserved gate region; other site
656519006869	putative PBP binding loops; other site
656519006870	ABC-ATPase subunit interface; other site
656519006871	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519006872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006873	dimer interface [polypeptide binding]; other site
656519006874	conserved gate region; other site
656519006875	putative PBP binding loops; other site
656519006876	ABC-ATPase subunit interface; other site
656519006877	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
656519006878	active site
656519006879	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
656519006880	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
656519006881	active site residue [active]
656519006882	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
656519006883	active site residue [active]
656519006884	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
656519006885	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
656519006886	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
656519006887	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
656519006888	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
656519006889	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
656519006890	trimerization site [polypeptide binding]; other site
656519006891	active site
656519006892	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
656519006893	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
656519006894	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519006895	catalytic residue [active]
656519006896	FeS assembly protein SufD; Region: sufD; TIGR01981
656519006897	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
656519006898	FeS assembly protein SufB; Region: sufB; TIGR01980
656519006899	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
656519006900	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
656519006901	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
656519006902	Walker A/P-loop; other site
656519006903	ATP binding site [chemical binding]; other site
656519006904	Q-loop/lid; other site
656519006905	ABC transporter signature motif; other site
656519006906	Walker B; other site
656519006907	D-loop; other site
656519006908	H-loop/switch region; other site
656519006909	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
656519006910	Domain of unknown function DUF20; Region: UPF0118; pfam01594
656519006911	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
656519006912	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
656519006913	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
656519006914	carboxyltransferase (CT) interaction site; other site
656519006915	biotinylation site [posttranslational modification]; other site
656519006916	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
656519006917	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
656519006918	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
656519006919	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
656519006920	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
656519006921	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
656519006922	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
656519006923	Walker A/P-loop; other site
656519006924	ATP binding site [chemical binding]; other site
656519006925	Q-loop/lid; other site
656519006926	ABC transporter signature motif; other site
656519006927	Walker B; other site
656519006928	D-loop; other site
656519006929	H-loop/switch region; other site
656519006930	TOBE domain; Region: TOBE_2; pfam08402
656519006931	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
656519006932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006933	dimer interface [polypeptide binding]; other site
656519006934	conserved gate region; other site
656519006935	putative PBP binding loops; other site
656519006936	ABC-ATPase subunit interface; other site
656519006937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519006938	dimer interface [polypeptide binding]; other site
656519006939	conserved gate region; other site
656519006940	putative PBP binding loops; other site
656519006941	ABC-ATPase subunit interface; other site
656519006942	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
656519006943	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
656519006944	EDD domain protein, DegV family; Region: DegV; TIGR00762
656519006945	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
656519006946	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
656519006947	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
656519006948	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
656519006949	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
656519006950	Hexamer interface [polypeptide binding]; other site
656519006951	Hexagonal pore residue; other site
656519006952	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
656519006953	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
656519006954	putative hexamer interface [polypeptide binding]; other site
656519006955	putative hexagonal pore; other site
656519006956	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
656519006957	Hexamer interface [polypeptide binding]; other site
656519006958	Hexagonal pore residue; other site
656519006959	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
656519006960	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
656519006961	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
656519006962	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
656519006963	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
656519006964	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
656519006965	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
656519006966	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
656519006967	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
656519006968	putative hexamer interface [polypeptide binding]; other site
656519006969	putative hexagonal pore; other site
656519006970	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
656519006971	putative hexamer interface [polypeptide binding]; other site
656519006972	putative hexagonal pore; other site
656519006973	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
656519006974	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519006975	motif II; other site
656519006976	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
656519006977	Major Facilitator Superfamily; Region: MFS_1; pfam07690
656519006978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519006979	glycerate dehydrogenase; Provisional; Region: PRK06487
656519006980	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
656519006981	putative ligand binding site [chemical binding]; other site
656519006982	putative NAD binding site [chemical binding]; other site
656519006983	catalytic site [active]
656519006984	lipoyl synthase; Provisional; Region: PRK05481
656519006985	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519006986	FeS/SAM binding site; other site
656519006987	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
656519006988	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
656519006989	dimer interface [polypeptide binding]; other site
656519006990	FMN binding site [chemical binding]; other site
656519006991	Uncharacterized conserved protein [Function unknown]; Region: COG2006
656519006992	Domain of unknown function (DUF362); Region: DUF362; pfam04015
656519006993	transaminase; Validated; Region: PRK07324
656519006994	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519006995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519006996	homodimer interface [polypeptide binding]; other site
656519006997	catalytic residue [active]
656519006998	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
656519006999	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
656519007000	homotetramer interface [polypeptide binding]; other site
656519007001	ligand binding site [chemical binding]; other site
656519007002	catalytic site [active]
656519007003	NAD binding site [chemical binding]; other site
656519007004	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
656519007005	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
656519007006	catalytic residues [active]
656519007007	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
656519007008	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
656519007009	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519007010	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
656519007011	active site
656519007012	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
656519007013	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
656519007014	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
656519007015	phosphate binding site [ion binding]; other site
656519007016	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
656519007017	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
656519007018	NTPase; Region: NTPase_1; cl17478
656519007019	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
656519007020	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
656519007021	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
656519007022	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
656519007023	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
656519007024	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
656519007025	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
656519007026	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
656519007027	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
656519007028	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519007029	active site
656519007030	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
656519007031	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
656519007032	active site
656519007033	putative substrate binding pocket [chemical binding]; other site
656519007034	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
656519007035	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
656519007036	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
656519007037	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
656519007038	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
656519007039	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
656519007040	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
656519007041	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
656519007042	probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316
656519007043	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
656519007044	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
656519007045	peptidase; Reviewed; Region: PRK13004
656519007046	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
656519007047	putative metal binding site [ion binding]; other site
656519007048	putative dimer interface [polypeptide binding]; other site
656519007049	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
656519007050	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
656519007051	non-specific DNA binding site [nucleotide binding]; other site
656519007052	salt bridge; other site
656519007053	sequence-specific DNA binding site [nucleotide binding]; other site
656519007054	Cupin domain; Region: Cupin_2; pfam07883
656519007055	threonine synthase; Validated; Region: PRK06260
656519007056	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
656519007057	homodimer interface [polypeptide binding]; other site
656519007058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007059	catalytic residue [active]
656519007060	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
656519007061	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519007062	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
656519007063	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
656519007064	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
656519007065	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
656519007066	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
656519007067	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
656519007068	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
656519007069	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
656519007070	intersubunit interface [polypeptide binding]; other site
656519007071	active site
656519007072	Zn2+ binding site [ion binding]; other site
656519007073	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
656519007074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519007075	Major Facilitator Superfamily; Region: MFS_1; pfam07690
656519007076	putative substrate translocation pore; other site
656519007077	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
656519007078	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
656519007079	O-Antigen ligase; Region: Wzy_C; pfam04932
656519007080	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
656519007081	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
656519007082	putative ADP-binding pocket [chemical binding]; other site
656519007083	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
656519007084	putative metal binding site; other site
656519007085	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
656519007086	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
656519007087	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
656519007088	putative active site [active]
656519007089	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
656519007090	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
656519007091	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
656519007092	putative active site [active]
656519007093	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
656519007094	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
656519007095	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
656519007096	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
656519007097	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
656519007098	putative acyl-acceptor binding pocket; other site
656519007099	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
656519007100	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
656519007101	putative active site [active]
656519007102	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
656519007103	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
656519007104	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
656519007105	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
656519007106	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
656519007107	Ligand binding site; other site
656519007108	oligomer interface; other site
656519007109	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
656519007110	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
656519007111	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
656519007112	putative acyl-acceptor binding pocket; other site
656519007113	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
656519007114	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
656519007115	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
656519007116	Walker A/P-loop; other site
656519007117	ATP binding site [chemical binding]; other site
656519007118	Q-loop/lid; other site
656519007119	ABC transporter signature motif; other site
656519007120	Walker B; other site
656519007121	D-loop; other site
656519007122	H-loop/switch region; other site
656519007123	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cl07944
656519007124	hexamer interface [polypeptide binding]; other site
656519007125	RNA binding site [nucleotide binding]; other site
656519007126	Histidine-zinc binding site [chemical binding]; other site
656519007127	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
656519007128	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
656519007129	cobalamin binding residues [chemical binding]; other site
656519007130	putative BtuC binding residues; other site
656519007131	dimer interface [polypeptide binding]; other site
656519007132	NAD synthetase; Provisional; Region: PRK13980
656519007133	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
656519007134	homodimer interface [polypeptide binding]; other site
656519007135	NAD binding pocket [chemical binding]; other site
656519007136	ATP binding pocket [chemical binding]; other site
656519007137	Mg binding site [ion binding]; other site
656519007138	active-site loop [active]
656519007139	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
656519007140	substrate binding site [chemical binding]; other site
656519007141	activation loop (A-loop); other site
656519007142	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
656519007143	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
656519007144	active site
656519007145	dimer interface [polypeptide binding]; other site
656519007146	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
656519007147	dimer interface [polypeptide binding]; other site
656519007148	active site
656519007149	Predicted permease; Region: DUF318; cl17795
656519007150	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519007151	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
656519007152	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
656519007153	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007154	dimer interface [polypeptide binding]; other site
656519007155	conserved gate region; other site
656519007156	putative PBP binding loops; other site
656519007157	ABC-ATPase subunit interface; other site
656519007158	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519007159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007160	dimer interface [polypeptide binding]; other site
656519007161	conserved gate region; other site
656519007162	putative PBP binding loops; other site
656519007163	ABC-ATPase subunit interface; other site
656519007164	Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880
656519007165	non-heme iron binding site [ion binding]; other site
656519007166	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
656519007167	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
656519007168	G1 box; other site
656519007169	putative GEF interaction site [polypeptide binding]; other site
656519007170	GTP/Mg2+ binding site [chemical binding]; other site
656519007171	Switch I region; other site
656519007172	G2 box; other site
656519007173	G3 box; other site
656519007174	Switch II region; other site
656519007175	G4 box; other site
656519007176	G5 box; other site
656519007177	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
656519007178	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
656519007179	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
656519007180	DNA-binding site [nucleotide binding]; DNA binding site
656519007181	RNA-binding motif; other site
656519007182	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
656519007183	DNA-binding site [nucleotide binding]; DNA binding site
656519007184	RNA-binding motif; other site
656519007185	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
656519007186	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
656519007187	substrate binding site [chemical binding]; other site
656519007188	active site
656519007189	catalytic residues [active]
656519007190	heterodimer interface [polypeptide binding]; other site
656519007191	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
656519007192	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
656519007193	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007194	catalytic residue [active]
656519007195	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
656519007196	active site
656519007197	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
656519007198	active site
656519007199	ribulose/triose binding site [chemical binding]; other site
656519007200	phosphate binding site [ion binding]; other site
656519007201	substrate (anthranilate) binding pocket [chemical binding]; other site
656519007202	product (indole) binding pocket [chemical binding]; other site
656519007203	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
656519007204	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
656519007205	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
656519007206	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
656519007207	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
656519007208	glutamine binding [chemical binding]; other site
656519007209	catalytic triad [active]
656519007210	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
656519007211	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
656519007212	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
656519007213	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
656519007214	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
656519007215	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
656519007216	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
656519007217	dimer interface [polypeptide binding]; other site
656519007218	active site
656519007219	metal binding site [ion binding]; metal-binding site
656519007220	maltose phosphorylase; Provisional; Region: PRK13807
656519007221	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
656519007222	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
656519007223	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
656519007224	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
656519007225	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
656519007226	motif II; other site
656519007227	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
656519007228	GAF domain; Region: GAF_2; pfam13185
656519007229	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
656519007230	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
656519007231	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
656519007232	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
656519007233	catalytic residue [active]
656519007234	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
656519007235	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
656519007236	putative dimer interface [polypeptide binding]; other site
656519007237	AAA domain; Region: AAA_32; pfam13654
656519007238	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
656519007239	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
656519007240	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
656519007241	CoA binding domain; Region: CoA_binding; pfam02629
656519007242	phenylhydantoinase; Validated; Region: PRK08323
656519007243	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
656519007244	active site
656519007245	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
656519007246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
656519007247	Walker A/P-loop; other site
656519007248	ATP binding site [chemical binding]; other site
656519007249	Q-loop/lid; other site
656519007250	ABC transporter signature motif; other site
656519007251	Walker B; other site
656519007252	D-loop; other site
656519007253	H-loop/switch region; other site
656519007254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007255	dimer interface [polypeptide binding]; other site
656519007256	conserved gate region; other site
656519007257	putative PBP binding loops; other site
656519007258	ABC-ATPase subunit interface; other site
656519007259	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
656519007260	PBP superfamily domain; Region: PBP_like_2; pfam12849
656519007261	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
656519007262	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
656519007263	Ca binding site [ion binding]; other site
656519007264	active site
656519007265	catalytic site [active]
656519007266	Transcriptional regulators [Transcription]; Region: PurR; COG1609
656519007267	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
656519007268	DNA binding site [nucleotide binding]
656519007269	domain linker motif; other site
656519007270	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
656519007271	ligand binding site [chemical binding]; other site
656519007272	dimerization interface [polypeptide binding]; other site
656519007273	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
656519007274	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
656519007275	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519007276	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519007277	Integrase core domain; Region: rve; pfam00665
656519007278	Predicted amidohydrolase [General function prediction only]; Region: COG0388
656519007279	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
656519007280	active site
656519007281	catalytic triad [active]
656519007282	dimer interface [polypeptide binding]; other site
656519007283	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
656519007284	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
656519007285	N-terminal plug; other site
656519007286	ligand-binding site [chemical binding]; other site
656519007287	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
656519007288	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
656519007289	Walker A/P-loop; other site
656519007290	ATP binding site [chemical binding]; other site
656519007291	Q-loop/lid; other site
656519007292	ABC transporter signature motif; other site
656519007293	Walker B; other site
656519007294	D-loop; other site
656519007295	H-loop/switch region; other site
656519007296	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
656519007297	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519007298	ABC-ATPase subunit  interface; other site
656519007299	dimer interface [polypeptide binding]; other site
656519007300	putative PBP binding regions; other site
656519007301	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
656519007302	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519007303	intersubunit interface [polypeptide binding]; other site
656519007304	cobalamin synthase; Reviewed; Region: cobS; PRK00235
656519007305	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
656519007306	homotrimer interface [polypeptide binding]; other site
656519007307	Walker A motif; other site
656519007308	GTP binding site [chemical binding]; other site
656519007309	Walker B motif; other site
656519007310	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
656519007311	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
656519007312	putative dimer interface [polypeptide binding]; other site
656519007313	active site pocket [active]
656519007314	putative cataytic base [active]
656519007315	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
656519007316	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519007317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007318	homodimer interface [polypeptide binding]; other site
656519007319	catalytic residue [active]
656519007320	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
656519007321	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
656519007322	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
656519007323	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
656519007324	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
656519007325	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
656519007326	catalytic triad [active]
656519007327	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
656519007328	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
656519007329	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
656519007330	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
656519007331	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
656519007332	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
656519007333	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
656519007334	active site
656519007335	SAM binding site [chemical binding]; other site
656519007336	homodimer interface [polypeptide binding]; other site
656519007337	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
656519007338	active site
656519007339	SAM binding site [chemical binding]; other site
656519007340	homodimer interface [polypeptide binding]; other site
656519007341	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
656519007342	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
656519007343	active site
656519007344	C-terminal domain interface [polypeptide binding]; other site
656519007345	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
656519007346	active site
656519007347	N-terminal domain interface [polypeptide binding]; other site
656519007348	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
656519007349	active site
656519007350	SAM binding site [chemical binding]; other site
656519007351	homodimer interface [polypeptide binding]; other site
656519007352	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
656519007353	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519007354	S-adenosylmethionine binding site [chemical binding]; other site
656519007355	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
656519007356	active site
656519007357	putative homodimer interface [polypeptide binding]; other site
656519007358	SAM binding site [chemical binding]; other site
656519007359	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
656519007360	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
656519007361	Precorrin-8X methylmutase; Region: CbiC; pfam02570
656519007362	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
656519007363	cobyric acid synthase; Provisional; Region: PRK00784
656519007364	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
656519007365	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
656519007366	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
656519007367	catalytic triad [active]
656519007368	cobyric acid synthase; Provisional; Region: PRK00784
656519007369	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
656519007370	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
656519007371	catalytic triad [active]
656519007372	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
656519007373	catalytic core [active]
656519007374	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
656519007375	homodimer interaction site [polypeptide binding]; other site
656519007376	cofactor binding site; other site
656519007377	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
656519007378	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
656519007379	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
656519007380	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
656519007381	Walker A/P-loop; other site
656519007382	ATP binding site [chemical binding]; other site
656519007383	Q-loop/lid; other site
656519007384	ABC transporter signature motif; other site
656519007385	Walker B; other site
656519007386	D-loop; other site
656519007387	H-loop/switch region; other site
656519007388	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
656519007389	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519007390	ABC-ATPase subunit  interface; other site
656519007391	dimer interface [polypeptide binding]; other site
656519007392	putative PBP binding regions; other site
656519007393	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
656519007394	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
656519007395	putative metal binding site [ion binding]; other site
656519007396	nickel responsive regulator; Provisional; Region: PRK04460
656519007397	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
656519007398	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
656519007399	AIR carboxylase; Region: AIRC; smart01001
656519007400	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
656519007401	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
656519007402	Ligand Binding Site [chemical binding]; other site
656519007403	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
656519007404	hypothetical protein; Provisional; Region: PRK00955
656519007405	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
656519007406	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
656519007407	putative active site pocket [active]
656519007408	cleavage site
656519007409	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
656519007410	PhoU domain; Region: PhoU; pfam01895
656519007411	PhoU domain; Region: PhoU; pfam01895
656519007412	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
656519007413	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
656519007414	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
656519007415	catalytic residue [active]
656519007416	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
656519007417	AzlC protein; Region: AzlC; cl00570
656519007418	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
656519007419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007420	dimer interface [polypeptide binding]; other site
656519007421	conserved gate region; other site
656519007422	putative PBP binding loops; other site
656519007423	ABC-ATPase subunit interface; other site
656519007424	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
656519007425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007426	dimer interface [polypeptide binding]; other site
656519007427	conserved gate region; other site
656519007428	putative PBP binding loops; other site
656519007429	ABC-ATPase subunit interface; other site
656519007430	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
656519007431	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
656519007432	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
656519007433	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
656519007434	catalytic triad [active]
656519007435	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
656519007436	XdhC Rossmann domain; Region: XdhC_C; pfam13478
656519007437	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
656519007438	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
656519007439	Walker A/P-loop; other site
656519007440	ATP binding site [chemical binding]; other site
656519007441	Q-loop/lid; other site
656519007442	ABC transporter signature motif; other site
656519007443	Walker B; other site
656519007444	D-loop; other site
656519007445	H-loop/switch region; other site
656519007446	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
656519007447	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
656519007448	ABC-ATPase subunit  interface; other site
656519007449	dimer interface [polypeptide binding]; other site
656519007450	putative PBP binding regions; other site
656519007451	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
656519007452	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
656519007453	intersubunit interface [polypeptide binding]; other site
656519007454	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
656519007455	Transcriptional regulator [Transcription]; Region: LysR; COG0583
656519007456	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
656519007457	Ligand binding site; other site
656519007458	metal-binding site
656519007459	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
656519007460	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
656519007461	active site
656519007462	Na/Ca binding site [ion binding]; other site
656519007463	catalytic site [active]
656519007464	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
656519007465	DNA-binding site [nucleotide binding]; DNA binding site
656519007466	RNA-binding motif; other site
656519007467	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
656519007468	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
656519007469	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
656519007470	FeS/SAM binding site; other site
656519007471	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
656519007472	ATP cone domain; Region: ATP-cone; pfam03477
656519007473	Class III ribonucleotide reductase; Region: RNR_III; cd01675
656519007474	effector binding site; other site
656519007475	active site
656519007476	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
656519007477	protein-splicing catalytic site; other site
656519007478	thioester formation/cholesterol transfer; other site
656519007479	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
656519007480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
656519007481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
656519007482	Protein of unknown function (DUF541); Region: SIMPL; cl01077
656519007483	PAS domain S-box; Region: sensory_box; TIGR00229
656519007484	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519007485	putative active site [active]
656519007486	heme pocket [chemical binding]; other site
656519007487	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519007488	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519007489	metal binding site [ion binding]; metal-binding site
656519007490	I-site; other site
656519007491	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519007492	Zn2+ binding site [ion binding]; other site
656519007493	Mg2+ binding site [ion binding]; other site
656519007494	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
656519007495	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
656519007496	Transposase, Mutator family; Region: Transposase_mut; pfam00872
656519007497	MULE transposase domain; Region: MULE; pfam10551
656519007498	Transposase; Region: DDE_Tnp_ISL3; pfam01610
656519007499	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
656519007500	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
656519007501	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
656519007502	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
656519007503	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
656519007504	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
656519007505	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
656519007506	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
656519007507	purine monophosphate binding site [chemical binding]; other site
656519007508	dimer interface [polypeptide binding]; other site
656519007509	putative catalytic residues [active]
656519007510	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
656519007511	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
656519007512	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
656519007513	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
656519007514	active site
656519007515	substrate binding site [chemical binding]; other site
656519007516	cosubstrate binding site; other site
656519007517	catalytic site [active]
656519007518	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
656519007519	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
656519007520	dimerization interface [polypeptide binding]; other site
656519007521	putative ATP binding site [chemical binding]; other site
656519007522	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
656519007523	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
656519007524	active site
656519007525	tetramer interface [polypeptide binding]; other site
656519007526	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
656519007527	active site
656519007528	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
656519007529	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
656519007530	ATP binding site [chemical binding]; other site
656519007531	active site
656519007532	substrate binding site [chemical binding]; other site
656519007533	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
656519007534	Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595
656519007535	active site
656519007536	tetramer interface [polypeptide binding]; other site
656519007537	Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397
656519007538	AIR carboxylase; Region: AIRC; pfam00731
656519007539	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
656519007540	ATP-grasp domain; Region: ATP-grasp; pfam02222
656519007541	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
656519007542	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
656519007543	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
656519007544	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
656519007545	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
656519007546	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
656519007547	YibE/F-like protein; Region: YibE_F; pfam07907
656519007548	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
656519007549	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
656519007550	dimer interface [polypeptide binding]; other site
656519007551	active site
656519007552	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
656519007553	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
656519007554	putative active site [active]
656519007555	putative NTP binding site [chemical binding]; other site
656519007556	putative nucleic acid binding site [nucleotide binding]; other site
656519007557	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
656519007558	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
656519007559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
656519007560	active site
656519007561	phosphorylation site [posttranslational modification]
656519007562	intermolecular recognition site; other site
656519007563	dimerization interface [polypeptide binding]; other site
656519007564	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519007565	Walker A motif; other site
656519007566	ATP binding site [chemical binding]; other site
656519007567	Walker B motif; other site
656519007568	arginine finger; other site
656519007569	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
656519007570	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
656519007571	dimer interface [polypeptide binding]; other site
656519007572	phosphorylation site [posttranslational modification]
656519007573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
656519007574	ATP binding site [chemical binding]; other site
656519007575	Mg2+ binding site [ion binding]; other site
656519007576	G-X-G motif; other site
656519007577	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
656519007578	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
656519007579	substrate binding pocket [chemical binding]; other site
656519007580	membrane-bound complex binding site; other site
656519007581	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
656519007582	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
656519007583	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
656519007584	metal binding site [ion binding]; metal-binding site
656519007585	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
656519007586	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
656519007587	substrate binding site [chemical binding]; other site
656519007588	glutamase interaction surface [polypeptide binding]; other site
656519007589	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
656519007590	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
656519007591	catalytic residues [active]
656519007592	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
656519007593	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
656519007594	putative active site [active]
656519007595	oxyanion strand; other site
656519007596	catalytic triad [active]
656519007597	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
656519007598	putative active site pocket [active]
656519007599	4-fold oligomerization interface [polypeptide binding]; other site
656519007600	metal binding residues [ion binding]; metal-binding site
656519007601	3-fold/trimer interface [polypeptide binding]; other site
656519007602	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
656519007603	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519007604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007605	homodimer interface [polypeptide binding]; other site
656519007606	catalytic residue [active]
656519007607	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
656519007608	histidinol dehydrogenase; Region: hisD; TIGR00069
656519007609	NAD binding site [chemical binding]; other site
656519007610	dimerization interface [polypeptide binding]; other site
656519007611	product binding site; other site
656519007612	substrate binding site [chemical binding]; other site
656519007613	zinc binding site [ion binding]; other site
656519007614	catalytic residues [active]
656519007615	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
656519007616	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
656519007617	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
656519007618	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
656519007619	dimer interface [polypeptide binding]; other site
656519007620	motif 1; other site
656519007621	active site
656519007622	motif 2; other site
656519007623	motif 3; other site
656519007624	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
656519007625	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
656519007626	active site
656519007627	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
656519007628	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
656519007629	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
656519007630	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
656519007631	active site
656519007632	homotetramer interface [polypeptide binding]; other site
656519007633	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
656519007634	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
656519007635	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
656519007636	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007637	dimer interface [polypeptide binding]; other site
656519007638	conserved gate region; other site
656519007639	putative PBP binding loops; other site
656519007640	ABC-ATPase subunit interface; other site
656519007641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
656519007642	dimer interface [polypeptide binding]; other site
656519007643	conserved gate region; other site
656519007644	putative PBP binding loops; other site
656519007645	ABC-ATPase subunit interface; other site
656519007646	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
656519007647	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
656519007648	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
656519007649	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
656519007650	ligand binding site; other site
656519007651	oligomer interface; other site
656519007652	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
656519007653	dimer interface [polypeptide binding]; other site
656519007654	N-terminal domain interface [polypeptide binding]; other site
656519007655	sulfate 1 binding site; other site
656519007656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
656519007657	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
656519007658	putative substrate translocation pore; other site
656519007659	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
656519007660	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
656519007661	active site
656519007662	nucleophile elbow; other site
656519007663	NAD-dependent deacetylase; Provisional; Region: PRK00481
656519007664	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
656519007665	NAD+ binding site [chemical binding]; other site
656519007666	substrate binding site [chemical binding]; other site
656519007667	Zn binding site [ion binding]; other site
656519007668	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
656519007669	active site
656519007670	phosphorylation site [posttranslational modification]
656519007671	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
656519007672	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
656519007673	dimer interface [polypeptide binding]; other site
656519007674	active site
656519007675	metal binding site [ion binding]; metal-binding site
656519007676	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
656519007677	MgtE intracellular N domain; Region: MgtE_N; pfam03448
656519007678	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
656519007679	Divalent cation transporter; Region: MgtE; pfam01769
656519007680	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
656519007681	dimerization domain swap beta strand [polypeptide binding]; other site
656519007682	regulatory protein interface [polypeptide binding]; other site
656519007683	active site
656519007684	regulatory phosphorylation site [posttranslational modification]; other site
656519007685	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
656519007686	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
656519007687	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
656519007688	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
656519007689	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
656519007690	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
656519007691	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
656519007692	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
656519007693	Glucitol operon activator protein (GutM); Region: GutM; cl01890
656519007694	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
656519007695	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
656519007696	non-specific DNA interactions [nucleotide binding]; other site
656519007697	DNA binding site [nucleotide binding]
656519007698	sequence specific DNA binding site [nucleotide binding]; other site
656519007699	putative cAMP binding site [chemical binding]; other site
656519007700	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
656519007701	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
656519007702	E3 interaction surface; other site
656519007703	lipoyl attachment site [posttranslational modification]; other site
656519007704	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
656519007705	e3 binding domain; Region: E3_binding; pfam02817
656519007706	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
656519007707	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
656519007708	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
656519007709	alpha subunit interface [polypeptide binding]; other site
656519007710	TPP binding site [chemical binding]; other site
656519007711	heterodimer interface [polypeptide binding]; other site
656519007712	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
656519007713	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
656519007714	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
656519007715	tetramer interface [polypeptide binding]; other site
656519007716	TPP-binding site [chemical binding]; other site
656519007717	heterodimer interface [polypeptide binding]; other site
656519007718	phosphorylation loop region [posttranslational modification]
656519007719	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
656519007720	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
656519007721	NAD(P) binding site [chemical binding]; other site
656519007722	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
656519007723	PAS domain S-box; Region: sensory_box; TIGR00229
656519007724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519007725	putative active site [active]
656519007726	heme pocket [chemical binding]; other site
656519007727	PAS fold; Region: PAS_4; pfam08448
656519007728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
656519007729	PAS domain; Region: PAS_9; pfam13426
656519007730	putative active site [active]
656519007731	heme pocket [chemical binding]; other site
656519007732	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519007733	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519007734	metal binding site [ion binding]; metal-binding site
656519007735	active site
656519007736	I-site; other site
656519007737	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
656519007738	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
656519007739	Zn2+ binding site [ion binding]; other site
656519007740	Mg2+ binding site [ion binding]; other site
656519007741	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
656519007742	active site
656519007743	metal binding site [ion binding]; metal-binding site
656519007744	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
656519007745	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
656519007746	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
656519007747	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
656519007748	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
656519007749	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
656519007750	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
656519007751	DNA-binding site [nucleotide binding]; DNA binding site
656519007752	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
656519007753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007754	homodimer interface [polypeptide binding]; other site
656519007755	catalytic residue [active]
656519007756	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
656519007757	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
656519007758	active site
656519007759	multimer interface [polypeptide binding]; other site
656519007760	Methyltransferase domain; Region: Methyltransf_23; pfam13489
656519007761	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519007762	S-adenosylmethionine binding site [chemical binding]; other site
656519007763	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
656519007764	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
656519007765	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
656519007766	Cysteine-rich domain; Region: CCG; pfam02754
656519007767	Cysteine-rich domain; Region: CCG; pfam02754
656519007768	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
656519007769	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
656519007770	putative inner membrane protein; Provisional; Region: PRK11099
656519007771	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
656519007772	CPxP  motif; other site
656519007773	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
656519007774	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
656519007775	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
656519007776	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
656519007777	active site residue [active]
656519007778	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
656519007779	active site residue [active]
656519007780	Winged helix-turn helix; Region: HTH_29; pfam13551
656519007781	Helix-turn-helix domain; Region: HTH_28; pfam13518
656519007782	Integrase core domain; Region: rve; pfam00665
656519007783	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
656519007784	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
656519007785	dimerization interface [polypeptide binding]; other site
656519007786	DPS ferroxidase diiron center [ion binding]; other site
656519007787	ion pore; other site
656519007788	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
656519007789	Helix-turn-helix domain; Region: HTH_38; pfam13936
656519007790	Integrase core domain; Region: rve; pfam00665
656519007791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519007792	Transposase; Region: HTH_Tnp_1; pfam01527
656519007793	HTH-like domain; Region: HTH_21; pfam13276
656519007794	Integrase core domain; Region: rve; pfam00665
656519007795	Integrase core domain; Region: rve_3; pfam13683
656519007796	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
656519007797	Transposase; Region: HTH_Tnp_1; pfam01527
656519007798	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
656519007799	putative transposase OrfB; Reviewed; Region: PHA02517
656519007800	HTH-like domain; Region: HTH_21; pfam13276
656519007801	Integrase core domain; Region: rve; pfam00665
656519007802	Integrase core domain; Region: rve_3; pfam13683
656519007803	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
656519007804	Uncharacterized conserved protein [Function unknown]; Region: COG0432
656519007805	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
656519007806	MgtC family; Region: MgtC; pfam02308
656519007807	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
656519007808	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
656519007809	metal binding site [ion binding]; metal-binding site
656519007810	active site
656519007811	I-site; other site
656519007812	Putative serine esterase (DUF676); Region: DUF676; pfam05057
656519007813	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
656519007814	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
656519007815	dimer interface [polypeptide binding]; other site
656519007816	PYR/PP interface [polypeptide binding]; other site
656519007817	TPP binding site [chemical binding]; other site
656519007818	substrate binding site [chemical binding]; other site
656519007819	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
656519007820	Domain of unknown function; Region: EKR; smart00890
656519007821	4Fe-4S binding domain; Region: Fer4_6; pfam12837
656519007822	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
656519007823	TPP-binding site [chemical binding]; other site
656519007824	dimer interface [polypeptide binding]; other site
656519007825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519007826	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
656519007827	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
656519007828	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
656519007829	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
656519007830	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
656519007831	Membrane protein of unknown function; Region: DUF360; pfam04020
656519007832	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
656519007833	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
656519007834	dimer interface [polypeptide binding]; other site
656519007835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007836	catalytic residue [active]
656519007837	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
656519007838	serine O-acetyltransferase; Region: cysE; TIGR01172
656519007839	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
656519007840	trimer interface [polypeptide binding]; other site
656519007841	active site
656519007842	substrate binding site [chemical binding]; other site
656519007843	CoA binding site [chemical binding]; other site
656519007844	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
656519007845	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
656519007846	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
656519007847	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
656519007848	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
656519007849	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
656519007850	GDP-binding site [chemical binding]; other site
656519007851	ACT binding site; other site
656519007852	IMP binding site; other site
656519007853	adenylosuccinate lyase; Provisional; Region: PRK07380
656519007854	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
656519007855	tetramer interface [polypeptide binding]; other site
656519007856	active site
656519007857	DNA replication protein DnaC; Validated; Region: PRK06835
656519007858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
656519007859	Walker A motif; other site
656519007860	ATP binding site [chemical binding]; other site
656519007861	Walker B motif; other site
656519007862	arginine finger; other site
656519007863	replicative DNA helicase; Region: DnaB; TIGR00665
656519007864	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
656519007865	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
656519007866	Walker A motif; other site
656519007867	ATP binding site [chemical binding]; other site
656519007868	Walker B motif; other site
656519007869	DNA binding loops [nucleotide binding]
656519007870	PspC domain; Region: PspC; pfam04024
656519007871	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
656519007872	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
656519007873	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
656519007874	FtsX-like permease family; Region: FtsX; pfam02687
656519007875	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
656519007876	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
656519007877	FtsX-like permease family; Region: FtsX; pfam02687
656519007878	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
656519007879	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
656519007880	Walker A/P-loop; other site
656519007881	ATP binding site [chemical binding]; other site
656519007882	Q-loop/lid; other site
656519007883	ABC transporter signature motif; other site
656519007884	Walker B; other site
656519007885	D-loop; other site
656519007886	H-loop/switch region; other site
656519007887	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
656519007888	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
656519007889	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
656519007890	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
656519007891	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
656519007892	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
656519007893	Ligand Binding Site [chemical binding]; other site
656519007894	Transcriptional regulators [Transcription]; Region: PurR; COG1609
656519007895	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
656519007896	DNA binding site [nucleotide binding]
656519007897	domain linker motif; other site
656519007898	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
656519007899	ligand binding site [chemical binding]; other site
656519007900	dimerization interface [polypeptide binding]; other site
656519007901	Predicted permeases [General function prediction only]; Region: COG0679
656519007902	D-mannonate oxidoreductase; Provisional; Region: PRK08277
656519007903	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
656519007904	putative NAD(P) binding site [chemical binding]; other site
656519007905	active site
656519007906	mannonate dehydratase; Provisional; Region: PRK03906
656519007907	mannonate dehydratase; Region: uxuA; TIGR00695
656519007908	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
656519007909	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
656519007910	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
656519007911	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
656519007912	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
656519007913	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
656519007914	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
656519007915	dimer interface [polypeptide binding]; other site
656519007916	ssDNA binding site [nucleotide binding]; other site
656519007917	tetramer (dimer of dimers) interface [polypeptide binding]; other site
656519007918	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
656519007919	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
656519007920	active site
656519007921	GTP-binding protein YchF; Reviewed; Region: PRK09601
656519007922	YchF GTPase; Region: YchF; cd01900
656519007923	G1 box; other site
656519007924	GTP/Mg2+ binding site [chemical binding]; other site
656519007925	Switch I region; other site
656519007926	G2 box; other site
656519007927	Switch II region; other site
656519007928	G3 box; other site
656519007929	G4 box; other site
656519007930	G5 box; other site
656519007931	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
656519007932	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
656519007933	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
656519007934	binding surface
656519007935	TPR motif; other site
656519007936	TPR repeat; Region: TPR_11; pfam13414
656519007937	Tetratricopeptide repeat; Region: TPR_16; pfam13432
656519007938	Tetratricopeptide repeat; Region: TPR_17; pfam13431
656519007939	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
656519007940	tetramer interface [polypeptide binding]; other site
656519007941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007942	catalytic residue [active]
656519007943	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
656519007944	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
656519007945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
656519007946	tetramer interface [polypeptide binding]; other site
656519007947	catalytic residue [active]
656519007948	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
656519007949	lipoyl attachment site [posttranslational modification]; other site
656519007950	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
656519007951	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
656519007952	Protein of unknown function (DUF554); Region: DUF554; pfam04474
656519007953	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
656519007954	ParB-like nuclease domain; Region: ParB; smart00470
656519007955	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
656519007956	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
656519007957	P-loop; other site
656519007958	Magnesium ion binding site [ion binding]; other site
656519007959	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
656519007960	Magnesium ion binding site [ion binding]; other site
656519007961	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
656519007962	ParB-like nuclease domain; Region: ParB; smart00470
656519007963	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
656519007964	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
656519007965	S-adenosylmethionine binding site [chemical binding]; other site
656519007966	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
656519007967	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
656519007968	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
656519007969	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
656519007970	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
656519007971	trmE is a tRNA modification GTPase; Region: trmE; cd04164
656519007972	G1 box; other site
656519007973	GTP/Mg2+ binding site [chemical binding]; other site
656519007974	Switch I region; other site
656519007975	G2 box; other site
656519007976	Switch II region; other site
656519007977	G3 box; other site
656519007978	G4 box; other site
656519007979	G5 box; other site
656519007980	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
656519007981	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
656519007982	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
656519007983	G-X-X-G motif; other site
656519007984	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
656519007985	RxxxH motif; other site
656519007986	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
656519007987	Haemolytic domain; Region: Haemolytic; pfam01809
656519007988	ribonuclease P; Reviewed; Region: rnpA; PRK00499