-- dump date 20140619_110347 -- class Genbank::misc_feature -- table misc_feature_note -- id note 502025000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 502025000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025000004 Walker A motif; other site 502025000005 ATP binding site [chemical binding]; other site 502025000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 502025000007 Walker B motif; other site 502025000008 arginine finger; other site 502025000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 502025000010 DnaA box-binding interface [nucleotide binding]; other site 502025000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 502025000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 502025000013 putative DNA binding surface [nucleotide binding]; other site 502025000014 dimer interface [polypeptide binding]; other site 502025000015 beta-clamp/clamp loader binding surface; other site 502025000016 beta-clamp/translesion DNA polymerase binding surface; other site 502025000017 recombination protein F; Reviewed; Region: recF; PRK00064 502025000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025000019 Walker A/P-loop; other site 502025000020 ATP binding site [chemical binding]; other site 502025000021 Q-loop/lid; other site 502025000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025000023 ABC transporter signature motif; other site 502025000024 Walker B; other site 502025000025 D-loop; other site 502025000026 H-loop/switch region; other site 502025000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 502025000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025000029 Mg2+ binding site [ion binding]; other site 502025000030 G-X-G motif; other site 502025000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 502025000032 anchoring element; other site 502025000033 dimer interface [polypeptide binding]; other site 502025000034 ATP binding site [chemical binding]; other site 502025000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 502025000036 active site 502025000037 putative metal-binding site [ion binding]; other site 502025000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 502025000039 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 502025000040 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025000041 dimer interface [polypeptide binding]; other site 502025000042 active site 502025000043 CoA binding pocket [chemical binding]; other site 502025000044 multifunctional aminopeptidase A; Provisional; Region: PRK00913 502025000045 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 502025000046 interface (dimer of trimers) [polypeptide binding]; other site 502025000047 Substrate-binding/catalytic site; other site 502025000048 Zn-binding sites [ion binding]; other site 502025000049 Protein of unknown function DUF72; Region: DUF72; cl00777 502025000050 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 502025000051 active site 502025000052 intersubunit interactions; other site 502025000053 catalytic residue [active] 502025000054 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025000055 nudix motif; other site 502025000056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025000057 S-adenosylmethionine binding site [chemical binding]; other site 502025000058 excinuclease ABC subunit B; Provisional; Region: PRK05298 502025000059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025000060 ATP binding site [chemical binding]; other site 502025000061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025000062 nucleotide binding region [chemical binding]; other site 502025000063 ATP-binding site [chemical binding]; other site 502025000064 Ultra-violet resistance protein B; Region: UvrB; pfam12344 502025000065 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 502025000066 active site 502025000067 thiamine phosphate binding site [chemical binding]; other site 502025000068 pyrophosphate binding site [ion binding]; other site 502025000069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000070 binding surface 502025000071 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025000072 TPR motif; other site 502025000073 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025000074 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025000075 ligand binding site [chemical binding]; other site 502025000076 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025000077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000078 active site 502025000079 phosphorylation site [posttranslational modification] 502025000080 intermolecular recognition site; other site 502025000081 dimerization interface [polypeptide binding]; other site 502025000082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000083 Walker A motif; other site 502025000084 ATP binding site [chemical binding]; other site 502025000085 Walker B motif; other site 502025000086 arginine finger; other site 502025000087 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 502025000088 Uncharacterized conserved protein [Function unknown]; Region: COG3268 502025000089 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 502025000090 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025000091 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 502025000092 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 502025000093 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 502025000094 Part of AAA domain; Region: AAA_19; pfam13245 502025000095 Family description; Region: UvrD_C_2; pfam13538 502025000096 arginine decarboxylase; Provisional; Region: PRK05354 502025000097 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 502025000098 dimer interface [polypeptide binding]; other site 502025000099 active site 502025000100 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025000101 catalytic residues [active] 502025000102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025000103 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025000104 phosphopeptide binding site; other site 502025000105 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 502025000106 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 502025000107 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 502025000108 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 502025000109 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 502025000110 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 502025000111 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 502025000112 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025000113 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 502025000114 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 502025000115 CotH protein; Region: CotH; pfam08757 502025000116 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 502025000117 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 502025000118 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 502025000119 CHASE2 domain; Region: CHASE2; pfam05226 502025000120 GAF domain; Region: GAF_3; pfam13492 502025000121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025000122 DNA-directed RNA polymerase subunit D; Provisional; Region: PRK00783 502025000123 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 502025000124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025000125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025000126 DNA binding residues [nucleotide binding] 502025000127 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 502025000128 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 502025000129 active site 502025000130 purine riboside binding site [chemical binding]; other site 502025000131 glutathione synthetase; Provisional; Region: PRK05246 502025000132 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 502025000133 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 502025000134 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025000135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000136 active site 502025000137 phosphorylation site [posttranslational modification] 502025000138 intermolecular recognition site; other site 502025000139 dimerization interface [polypeptide binding]; other site 502025000140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000141 Walker A motif; other site 502025000142 ATP binding site [chemical binding]; other site 502025000143 Walker B motif; other site 502025000144 arginine finger; other site 502025000145 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025000146 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 502025000147 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025000148 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 502025000149 DNA binding residues [nucleotide binding] 502025000150 TPR repeat; Region: TPR_11; pfam13414 502025000151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000152 binding surface 502025000153 TPR motif; other site 502025000154 TPR repeat; Region: TPR_11; pfam13414 502025000155 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025000156 active site 502025000157 substrate binding sites [chemical binding]; other site 502025000158 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 502025000159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025000160 FeS/SAM binding site; other site 502025000161 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 502025000162 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025000163 FeS/SAM binding site; other site 502025000164 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 502025000165 phosphate binding site [ion binding]; other site 502025000166 dimer interface [polypeptide binding]; other site 502025000167 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 502025000168 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 502025000169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025000170 non-specific DNA binding site [nucleotide binding]; other site 502025000171 salt bridge; other site 502025000172 sequence-specific DNA binding site [nucleotide binding]; other site 502025000173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025000174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025000175 Protein of unknown function (DUF615); Region: DUF615; cl01147 502025000176 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 502025000177 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 502025000178 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 502025000179 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 502025000180 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025000181 Cytochrome P450; Region: p450; cl12078 502025000182 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 502025000183 Zn binding site [ion binding]; other site 502025000184 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025000185 tellurium resistance terB-like protein; Region: terB_like; cd07177 502025000186 metal binding site [ion binding]; metal-binding site 502025000187 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025000188 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 502025000189 active site 502025000190 metal binding site [ion binding]; metal-binding site 502025000191 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025000192 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025000193 ligand binding site [chemical binding]; other site 502025000194 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 502025000195 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 502025000196 TPP-binding site [chemical binding]; other site 502025000197 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 502025000198 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 502025000199 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 502025000200 dimer interface [polypeptide binding]; other site 502025000201 PYR/PP interface [polypeptide binding]; other site 502025000202 TPP binding site [chemical binding]; other site 502025000203 substrate binding site [chemical binding]; other site 502025000204 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025000205 Double zinc ribbon; Region: DZR; pfam12773 502025000206 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 502025000207 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000208 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000209 active site 502025000210 ATP binding site [chemical binding]; other site 502025000211 substrate binding site [chemical binding]; other site 502025000212 activation loop (A-loop); other site 502025000213 TPR repeat; Region: TPR_11; pfam13414 502025000214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000215 binding surface 502025000216 TPR motif; other site 502025000217 TPR repeat; Region: TPR_11; pfam13414 502025000218 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 502025000219 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 502025000220 VanZ like family; Region: VanZ; cl01971 502025000221 VanZ like family; Region: VanZ; cl01971 502025000222 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 502025000223 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025000224 acyl-CoA synthetase; Validated; Region: PRK07787 502025000225 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025000226 acyl-activating enzyme (AAE) consensus motif; other site 502025000227 AMP binding site [chemical binding]; other site 502025000228 active site 502025000229 CoA binding site [chemical binding]; other site 502025000230 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000231 active site 502025000232 ATP binding site [chemical binding]; other site 502025000233 substrate binding site [chemical binding]; other site 502025000234 activation loop (A-loop); other site 502025000235 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000236 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000237 Cache domain; Region: Cache_1; pfam02743 502025000238 chain length determinant protein EpsF; Region: EpsF; TIGR03017 502025000239 Chain length determinant protein; Region: Wzz; cl15801 502025000240 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 502025000241 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 502025000242 Nucleotide binding site [chemical binding]; other site 502025000243 P loop; other site 502025000244 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 502025000245 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 502025000246 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 502025000247 NAD(P) binding site [chemical binding]; other site 502025000248 NAD(P) binding pocket [chemical binding]; other site 502025000249 homodimer interface [polypeptide binding]; other site 502025000250 substrate binding site [chemical binding]; other site 502025000251 active site 502025000252 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 502025000253 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 502025000254 putative acyl-acceptor binding pocket; other site 502025000255 4Fe-4S binding domain; Region: Fer4; pfam00037 502025000256 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 502025000257 4Fe-4S binding domain; Region: Fer4; pfam00037 502025000258 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 502025000259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 502025000260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025000261 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000262 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000263 active site 502025000264 ATP binding site [chemical binding]; other site 502025000265 substrate binding site [chemical binding]; other site 502025000266 activation loop (A-loop); other site 502025000267 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000268 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 502025000269 Amidase; Region: Amidase; cl11426 502025000270 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 502025000271 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 502025000272 active site 502025000273 substrate binding site [chemical binding]; other site 502025000274 FMN binding site [chemical binding]; other site 502025000275 putative catalytic residues [active] 502025000276 YceI-like domain; Region: YceI; smart00867 502025000277 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025000278 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025000279 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025000280 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025000281 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025000282 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025000283 Ribosomal protein S21; Region: Ribosomal_S21; pfam01165 502025000284 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025000285 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025000286 P-loop; other site 502025000287 Magnesium ion binding site [ion binding]; other site 502025000288 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025000289 Magnesium ion binding site [ion binding]; other site 502025000290 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 502025000291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025000292 S-adenosylmethionine binding site [chemical binding]; other site 502025000293 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 502025000294 RNA methyltransferase, RsmE family; Region: TIGR00046 502025000295 RDD family; Region: RDD; pfam06271 502025000296 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025000297 HEAT repeats; Region: HEAT_2; pfam13646 502025000298 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 502025000299 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 502025000300 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 502025000301 active site 502025000302 catalytic site [active] 502025000303 Protein kinase domain; Region: Pkinase; pfam00069 502025000304 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000305 active site 502025000306 ATP binding site [chemical binding]; other site 502025000307 substrate binding site [chemical binding]; other site 502025000308 activation loop (A-loop); other site 502025000309 Predicted ATPase [General function prediction only]; Region: COG3899 502025000310 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025000311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000312 binding surface 502025000313 TPR motif; other site 502025000314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000315 binding surface 502025000316 TPR motif; other site 502025000317 PEGA domain; Region: PEGA; pfam08308 502025000318 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 502025000319 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025000320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025000321 homodimer interface [polypeptide binding]; other site 502025000322 catalytic residue [active] 502025000323 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 502025000324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025000325 RNA binding surface [nucleotide binding]; other site 502025000326 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025000327 active site 502025000328 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 502025000329 dimer interface [polypeptide binding]; other site 502025000330 substrate binding site [chemical binding]; other site 502025000331 metal binding sites [ion binding]; metal-binding site 502025000332 glutamate dehydrogenase; Provisional; Region: PRK09414 502025000333 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025000334 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 502025000335 NAD(P) binding site [chemical binding]; other site 502025000336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000337 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 502025000338 NAD(P) binding site [chemical binding]; other site 502025000339 active site 502025000340 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 502025000341 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 502025000342 active site 502025000343 HIGH motif; other site 502025000344 dimer interface [polypeptide binding]; other site 502025000345 KMSKS motif; other site 502025000346 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025000347 RNA binding surface [nucleotide binding]; other site 502025000348 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 502025000349 KH domain; Region: KH_1; pfam00013 502025000350 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 502025000351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025000352 Zn2+ binding site [ion binding]; other site 502025000353 Mg2+ binding site [ion binding]; other site 502025000354 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 502025000355 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 502025000356 Cell division protein ZapA; Region: ZapA; pfam05164 502025000357 Stage II sporulation protein; Region: SpoIID; pfam08486 502025000358 Family description; Region: VCBS; pfam13517 502025000359 Family description; Region: VCBS; pfam13517 502025000360 Family description; Region: VCBS; pfam13517 502025000361 Family description; Region: VCBS; pfam13517 502025000362 Family description; Region: VCBS; pfam13517 502025000363 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 502025000364 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 502025000365 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 502025000366 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 502025000367 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 502025000368 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 502025000369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025000370 catalytic residue [active] 502025000371 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 502025000372 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 502025000373 active site 502025000374 catalytic residues [active] 502025000375 metal binding site [ion binding]; metal-binding site 502025000376 Response regulator receiver domain; Region: Response_reg; pfam00072 502025000377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000378 active site 502025000379 phosphorylation site [posttranslational modification] 502025000380 intermolecular recognition site; other site 502025000381 dimerization interface [polypeptide binding]; other site 502025000382 TPR repeat; Region: TPR_11; pfam13414 502025000383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000384 binding surface 502025000385 TPR motif; other site 502025000386 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 502025000387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 502025000388 Walker A/P-loop; other site 502025000389 ATP binding site [chemical binding]; other site 502025000390 Q-loop/lid; other site 502025000391 ABC transporter signature motif; other site 502025000392 Walker B; other site 502025000393 D-loop; other site 502025000394 H-loop/switch region; other site 502025000395 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 502025000396 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 502025000397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 502025000398 Walker A/P-loop; other site 502025000399 ATP binding site [chemical binding]; other site 502025000400 Q-loop/lid; other site 502025000401 ABC transporter signature motif; other site 502025000402 Walker B; other site 502025000403 D-loop; other site 502025000404 H-loop/switch region; other site 502025000405 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 502025000406 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 502025000407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025000408 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 502025000409 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025000410 dimer interface [polypeptide binding]; other site 502025000411 active site 502025000412 CoA binding pocket [chemical binding]; other site 502025000413 exopolyphosphatase; Region: exo_poly_only; TIGR03706 502025000414 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 502025000415 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025000416 TolB amino-terminal domain; Region: TolB_N; pfam04052 502025000417 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000418 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000419 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000420 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000421 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025000422 TonB C terminal; Region: TonB_2; pfam13103 502025000423 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 502025000424 TolR protein; Region: tolR; TIGR02801 502025000425 TolQ protein; Region: tolQ; TIGR02796 502025000426 Eukaryotic integral membrane protein (DUF1751); Region: DUF1751; pfam08551 502025000427 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025000428 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025000429 phosphopeptide binding site; other site 502025000430 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025000431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000432 Walker A motif; other site 502025000433 ATP binding site [chemical binding]; other site 502025000434 Walker B motif; other site 502025000435 arginine finger; other site 502025000436 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 502025000437 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 502025000438 active site 502025000439 HIGH motif; other site 502025000440 dimer interface [polypeptide binding]; other site 502025000441 KMSKS motif; other site 502025000442 Putative zinc-finger; Region: zf-HC2; pfam13490 502025000443 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 502025000444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025000445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025000446 DNA binding residues [nucleotide binding] 502025000447 hypothetical protein; Reviewed; Region: PRK00024 502025000448 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 502025000449 MPN+ (JAMM) motif; other site 502025000450 Zinc-binding site [ion binding]; other site 502025000451 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 502025000452 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 502025000453 interface (dimer of trimers) [polypeptide binding]; other site 502025000454 Substrate-binding/catalytic site; other site 502025000455 Zn-binding sites [ion binding]; other site 502025000456 hypothetical protein; Provisional; Region: PRK09256 502025000457 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 502025000458 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 502025000459 nucleotide binding site [chemical binding]; other site 502025000460 putative NEF/HSP70 interaction site [polypeptide binding]; other site 502025000461 SBD interface [polypeptide binding]; other site 502025000462 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 502025000463 nucleotide binding site [chemical binding]; other site 502025000464 putative NEF/HSP70 interaction site [polypeptide binding]; other site 502025000465 SBD interface [polypeptide binding]; other site 502025000466 DNA-K related protein; Region: DUF3731; pfam12531 502025000467 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025000468 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025000469 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025000470 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025000471 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 502025000472 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 502025000473 dimerization interface [polypeptide binding]; other site 502025000474 domain crossover interface; other site 502025000475 redox-dependent activation switch; other site 502025000476 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 502025000477 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 502025000478 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 502025000479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025000480 catalytic residue [active] 502025000481 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 502025000482 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 502025000483 putative efflux protein, MATE family; Region: matE; TIGR00797 502025000484 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025000485 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025000486 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025000487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000488 binding surface 502025000489 TPR motif; other site 502025000490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000491 TPR motif; other site 502025000492 binding surface 502025000493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025000494 TPR motif; other site 502025000495 TPR repeat; Region: TPR_11; pfam13414 502025000496 binding surface 502025000497 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 502025000498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000499 TPR motif; other site 502025000500 binding surface 502025000501 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 502025000502 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 502025000503 substrate binding site [chemical binding]; other site 502025000504 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 502025000505 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 502025000506 substrate binding site [chemical binding]; other site 502025000507 ligand binding site [chemical binding]; other site 502025000508 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 502025000509 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 502025000510 Part of AAA domain; Region: AAA_19; pfam13245 502025000511 Family description; Region: UvrD_C_2; pfam13538 502025000512 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000513 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000514 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000515 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000516 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000517 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000518 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000519 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000520 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000521 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000522 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000523 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000524 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000525 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000526 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000527 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025000528 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000529 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025000530 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000531 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000532 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000533 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000534 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000535 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025000536 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025000537 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025000538 active site 502025000539 metal binding site [ion binding]; metal-binding site 502025000540 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025000541 metal ion-dependent adhesion site (MIDAS); other site 502025000542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 502025000543 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 502025000544 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 502025000545 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 502025000546 substrate binding site [chemical binding]; other site 502025000547 active site 502025000548 putative catalytic residue [active] 502025000549 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 502025000550 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025000551 ATP binding site [chemical binding]; other site 502025000552 putative Mg++ binding site [ion binding]; other site 502025000553 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025000554 nucleotide binding region [chemical binding]; other site 502025000555 ATP-binding site [chemical binding]; other site 502025000556 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 502025000557 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 502025000558 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 502025000559 heme-binding site [chemical binding]; other site 502025000560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 502025000561 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 502025000562 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 502025000563 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025000564 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 502025000565 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 502025000566 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 502025000567 Walker A/P-loop; other site 502025000568 ATP binding site [chemical binding]; other site 502025000569 Q-loop/lid; other site 502025000570 ABC transporter signature motif; other site 502025000571 Walker B; other site 502025000572 D-loop; other site 502025000573 H-loop/switch region; other site 502025000574 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025000575 catalytic core [active] 502025000576 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 502025000577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025000578 FeS/SAM binding site; other site 502025000579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000580 Walker A motif; other site 502025000581 ATP binding site [chemical binding]; other site 502025000582 Walker B motif; other site 502025000583 arginine finger; other site 502025000584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000585 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025000586 Walker A motif; other site 502025000587 ATP binding site [chemical binding]; other site 502025000588 Walker B motif; other site 502025000589 arginine finger; other site 502025000590 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025000591 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025000592 structural tetrad; other site 502025000593 Protein of unknown function DUF72; Region: DUF72; pfam01904 502025000594 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000595 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000596 active site 502025000597 ATP binding site [chemical binding]; other site 502025000598 substrate binding site [chemical binding]; other site 502025000599 activation loop (A-loop); other site 502025000600 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 502025000601 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 502025000602 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 502025000603 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 502025000604 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 502025000605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 502025000606 Chain length determinant protein; Region: Wzz; cl15801 502025000607 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 502025000608 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 502025000609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025000610 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 502025000611 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025000612 anti sigma factor interaction site; other site 502025000613 regulatory phosphorylation site [posttranslational modification]; other site 502025000614 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 502025000615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025000616 Bacterial sugar transferase; Region: Bac_transf; pfam02397 502025000617 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 502025000618 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 502025000619 SLBB domain; Region: SLBB; pfam10531 502025000620 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 502025000621 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 502025000622 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 502025000623 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 502025000624 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 502025000625 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 502025000626 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 502025000627 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025000628 dimer interface [polypeptide binding]; other site 502025000629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025000630 catalytic residue [active] 502025000631 Esterase/lipase [General function prediction only]; Region: COG1647 502025000632 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025000633 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025000634 phosphopeptide binding site; other site 502025000635 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025000636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025000637 metal binding site [ion binding]; metal-binding site 502025000638 active site 502025000639 I-site; other site 502025000640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025000641 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 502025000642 putative ADP-binding pocket [chemical binding]; other site 502025000643 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 502025000644 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 502025000645 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025000646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000647 active site 502025000648 phosphorylation site [posttranslational modification] 502025000649 intermolecular recognition site; other site 502025000650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025000651 dimerization interface [polypeptide binding]; other site 502025000652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025000653 dimer interface [polypeptide binding]; other site 502025000654 phosphorylation site [posttranslational modification] 502025000655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025000656 ATP binding site [chemical binding]; other site 502025000657 Mg2+ binding site [ion binding]; other site 502025000658 G-X-G motif; other site 502025000659 Response regulator receiver domain; Region: Response_reg; pfam00072 502025000660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000661 active site 502025000662 phosphorylation site [posttranslational modification] 502025000663 intermolecular recognition site; other site 502025000664 dimerization interface [polypeptide binding]; other site 502025000665 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000666 active site 502025000667 ATP binding site [chemical binding]; other site 502025000668 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000669 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000670 substrate binding site [chemical binding]; other site 502025000671 activation loop (A-loop); other site 502025000672 AAA ATPase domain; Region: AAA_16; pfam13191 502025000673 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 502025000674 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 502025000675 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 502025000676 homodimer interface [polypeptide binding]; other site 502025000677 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 502025000678 active site pocket [active] 502025000679 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025000680 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 502025000681 active site 502025000682 catalytic triad [active] 502025000683 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 502025000684 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 502025000685 PA/protease or protease-like domain interface [polypeptide binding]; other site 502025000686 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 502025000687 catalytic residues [active] 502025000688 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025000689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000690 Walker A motif; other site 502025000691 ATP binding site [chemical binding]; other site 502025000692 Walker B motif; other site 502025000693 arginine finger; other site 502025000694 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025000695 metal ion-dependent adhesion site (MIDAS); other site 502025000696 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 502025000697 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025000698 dimer interface [polypeptide binding]; other site 502025000699 active site 502025000700 CoA binding pocket [chemical binding]; other site 502025000701 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 502025000702 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 502025000703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000704 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025000705 Walker A motif; other site 502025000706 ATP binding site [chemical binding]; other site 502025000707 Walker B motif; other site 502025000708 arginine finger; other site 502025000709 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 502025000710 hypothetical protein; Reviewed; Region: PRK09588 502025000711 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 502025000712 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 502025000713 putative active site [active] 502025000714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000715 binding surface 502025000716 TPR motif; other site 502025000717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000718 TPR motif; other site 502025000719 binding surface 502025000720 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 502025000721 Na binding site [ion binding]; other site 502025000722 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 502025000723 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025000724 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025000725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 502025000726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 502025000727 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 502025000728 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 502025000729 nucleotide binding site [chemical binding]; other site 502025000730 putative NEF/HSP70 interaction site [polypeptide binding]; other site 502025000731 SBD interface [polypeptide binding]; other site 502025000732 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 502025000733 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 502025000734 metal ion-dependent adhesion site (MIDAS); other site 502025000735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 502025000736 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025000737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000738 Walker A motif; other site 502025000739 ATP binding site [chemical binding]; other site 502025000740 Walker B motif; other site 502025000741 arginine finger; other site 502025000742 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025000743 Competence protein A; Region: Competence_A; pfam11104 502025000744 Cell division protein FtsA; Region: FtsA; cl17206 502025000745 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 502025000746 Pilus assembly protein, PilO; Region: PilO; cl01234 502025000747 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 502025000748 Secretin and TonB N terminus short domain; Region: STN; pfam07660 502025000749 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 502025000750 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 502025000751 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 502025000752 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 502025000753 ADP binding site [chemical binding]; other site 502025000754 magnesium binding site [ion binding]; other site 502025000755 putative shikimate binding site; other site 502025000756 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 502025000757 active site 502025000758 dimer interface [polypeptide binding]; other site 502025000759 metal binding site [ion binding]; metal-binding site 502025000760 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 502025000761 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 502025000762 Dehydroquinase class II; Region: DHquinase_II; pfam01220 502025000763 trimer interface [polypeptide binding]; other site 502025000764 active site 502025000765 dimer interface [polypeptide binding]; other site 502025000766 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 502025000767 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025000768 carboxyltransferase (CT) interaction site; other site 502025000769 biotinylation site [posttranslational modification]; other site 502025000770 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 502025000771 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025000772 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 502025000773 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 502025000774 TPR repeat; Region: TPR_11; pfam13414 502025000775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000776 TPR motif; other site 502025000777 binding surface 502025000778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000779 TPR motif; other site 502025000780 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025000781 binding surface 502025000782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025000783 TPR repeat; Region: TPR_11; pfam13414 502025000784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025000785 binding surface 502025000786 TPR motif; other site 502025000787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025000788 dimerization interface [polypeptide binding]; other site 502025000789 DNA binding residues [nucleotide binding] 502025000790 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 502025000791 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025000792 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025000793 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025000794 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025000795 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000796 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000797 active site 502025000798 ATP binding site [chemical binding]; other site 502025000799 substrate binding site [chemical binding]; other site 502025000800 activation loop (A-loop); other site 502025000801 PEGA domain; Region: PEGA; pfam08308 502025000802 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025000803 BolA-like protein; Region: BolA; pfam01722 502025000804 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025000805 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 502025000806 NAD(P) binding site [chemical binding]; other site 502025000807 catalytic residues [active] 502025000808 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 502025000809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025000810 Zn2+ binding site [ion binding]; other site 502025000811 Mg2+ binding site [ion binding]; other site 502025000812 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 502025000813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025000814 dimerization interface [polypeptide binding]; other site 502025000815 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025000816 dimer interface [polypeptide binding]; other site 502025000817 phosphorylation site [posttranslational modification] 502025000818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025000819 ATP binding site [chemical binding]; other site 502025000820 G-X-G motif; other site 502025000821 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025000822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000823 active site 502025000824 phosphorylation site [posttranslational modification] 502025000825 intermolecular recognition site; other site 502025000826 dimerization interface [polypeptide binding]; other site 502025000827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025000828 DNA binding site [nucleotide binding] 502025000829 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 502025000830 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025000831 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025000832 catalytic loop [active] 502025000833 iron binding site [ion binding]; other site 502025000834 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025000835 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025000836 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025000837 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025000838 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025000839 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 502025000840 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 502025000841 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025000842 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000843 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000844 active site 502025000845 ATP binding site [chemical binding]; other site 502025000846 substrate binding site [chemical binding]; other site 502025000847 activation loop (A-loop); other site 502025000848 Response regulator receiver domain; Region: Response_reg; pfam00072 502025000849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000850 active site 502025000851 phosphorylation site [posttranslational modification] 502025000852 intermolecular recognition site; other site 502025000853 dimerization interface [polypeptide binding]; other site 502025000854 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025000855 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025000856 metal binding site [ion binding]; metal-binding site 502025000857 active site 502025000858 I-site; other site 502025000859 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025000860 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025000861 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025000862 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 502025000863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025000864 FeS/SAM binding site; other site 502025000865 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 502025000866 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025000867 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025000868 DNA binding residues [nucleotide binding] 502025000869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 502025000870 active site 502025000871 phosphorylation site [posttranslational modification] 502025000872 intermolecular recognition site; other site 502025000873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025000874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025000875 phosphorylation site [posttranslational modification] 502025000876 dimer interface [polypeptide binding]; other site 502025000877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025000878 ATP binding site [chemical binding]; other site 502025000879 Mg2+ binding site [ion binding]; other site 502025000880 G-X-G motif; other site 502025000881 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025000882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025000883 active site 502025000884 phosphorylation site [posttranslational modification] 502025000885 intermolecular recognition site; other site 502025000886 dimerization interface [polypeptide binding]; other site 502025000887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025000888 Walker A motif; other site 502025000889 ATP binding site [chemical binding]; other site 502025000890 Walker B motif; other site 502025000891 arginine finger; other site 502025000892 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025000893 isocitrate dehydrogenase; Validated; Region: PRK06451 502025000894 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 502025000895 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025000896 Ligand Binding Site [chemical binding]; other site 502025000897 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025000898 Ligand Binding Site [chemical binding]; other site 502025000899 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025000900 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025000901 active site 502025000902 ATP binding site [chemical binding]; other site 502025000903 substrate binding site [chemical binding]; other site 502025000904 activation loop (A-loop); other site 502025000905 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025000906 glycerol kinase; Provisional; Region: glpK; PRK00047 502025000907 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 502025000908 N- and C-terminal domain interface [polypeptide binding]; other site 502025000909 active site 502025000910 MgATP binding site [chemical binding]; other site 502025000911 catalytic site [active] 502025000912 metal binding site [ion binding]; metal-binding site 502025000913 glycerol binding site [chemical binding]; other site 502025000914 homotetramer interface [polypeptide binding]; other site 502025000915 homodimer interface [polypeptide binding]; other site 502025000916 FBP binding site [chemical binding]; other site 502025000917 protein IIAGlc interface [polypeptide binding]; other site 502025000918 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025000919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025000920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025000921 DNA binding residues [nucleotide binding] 502025000922 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 502025000923 Transglycosylase; Region: Transgly; pfam00912 502025000924 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 502025000925 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025000926 phosphopeptide binding site; other site 502025000927 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025000928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000929 NAD(P) binding site [chemical binding]; other site 502025000930 active site 502025000931 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 502025000932 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 502025000933 inhibitor-cofactor binding pocket; inhibition site 502025000934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025000935 catalytic residue [active] 502025000936 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025000937 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 502025000938 Walker A/P-loop; other site 502025000939 ATP binding site [chemical binding]; other site 502025000940 Q-loop/lid; other site 502025000941 ABC transporter signature motif; other site 502025000942 Walker B; other site 502025000943 D-loop; other site 502025000944 H-loop/switch region; other site 502025000945 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 502025000946 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 502025000947 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 502025000948 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 502025000949 Walker A/P-loop; other site 502025000950 ATP binding site [chemical binding]; other site 502025000951 Q-loop/lid; other site 502025000952 ABC transporter signature motif; other site 502025000953 Walker B; other site 502025000954 D-loop; other site 502025000955 H-loop/switch region; other site 502025000956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025000957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025000958 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025000959 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025000960 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025000961 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 502025000962 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 502025000963 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 502025000964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025000965 S-adenosylmethionine binding site [chemical binding]; other site 502025000966 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 502025000967 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 502025000968 ligand binding site [chemical binding]; other site 502025000969 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 502025000970 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 502025000971 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 502025000972 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 502025000973 Septum formation initiator; Region: DivIC; pfam04977 502025000974 GAF domain; Region: GAF; cl17456 502025000975 GAF domain; Region: GAF_2; pfam13185 502025000976 GAF domain; Region: GAF_3; pfam13492 502025000977 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025000978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025000979 metal binding site [ion binding]; metal-binding site 502025000980 active site 502025000981 I-site; other site 502025000982 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 502025000983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025000984 NAD(P) binding site [chemical binding]; other site 502025000985 active site 502025000986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025000987 Coenzyme A binding pocket [chemical binding]; other site 502025000988 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 502025000989 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 502025000990 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025000991 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 502025000992 Walker A/P-loop; other site 502025000993 ATP binding site [chemical binding]; other site 502025000994 Q-loop/lid; other site 502025000995 ABC transporter signature motif; other site 502025000996 Walker B; other site 502025000997 D-loop; other site 502025000998 H-loop/switch region; other site 502025000999 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025001000 FtsX-like permease family; Region: FtsX; pfam02687 502025001001 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 502025001002 FtsX-like permease family; Region: FtsX; pfam02687 502025001003 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025001004 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025001005 Ligand Binding Site [chemical binding]; other site 502025001006 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025001007 Ligand Binding Site [chemical binding]; other site 502025001008 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 502025001009 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025001010 ATP binding site [chemical binding]; other site 502025001011 Mg++ binding site [ion binding]; other site 502025001012 motif III; other site 502025001013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025001014 nucleotide binding region [chemical binding]; other site 502025001015 ATP-binding site [chemical binding]; other site 502025001016 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 502025001017 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00934 502025001018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025001019 active site 502025001020 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 502025001021 YceI-like domain; Region: YceI; pfam04264 502025001022 YceI-like domain; Region: YceI; smart00867 502025001023 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 502025001024 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 502025001025 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 502025001026 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 502025001027 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 502025001028 ligand binding site; other site 502025001029 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 502025001030 TPP-binding site [chemical binding]; other site 502025001031 dimer interface [polypeptide binding]; other site 502025001032 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 502025001033 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 502025001034 PYR/PP interface [polypeptide binding]; other site 502025001035 dimer interface [polypeptide binding]; other site 502025001036 TPP binding site [chemical binding]; other site 502025001037 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025001038 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 502025001039 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025001040 inhibitor-cofactor binding pocket; inhibition site 502025001041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001042 catalytic residue [active] 502025001043 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 502025001044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001045 NAD(P) binding site [chemical binding]; other site 502025001046 active site 502025001047 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 502025001048 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 502025001049 NeuB family; Region: NeuB; pfam03102 502025001050 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 502025001051 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 502025001052 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 502025001053 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025001054 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 502025001055 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 502025001056 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 502025001057 active site 502025001058 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 502025001059 protein binding site [polypeptide binding]; other site 502025001060 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 502025001061 protein binding site [polypeptide binding]; other site 502025001062 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 502025001063 protein binding site [polypeptide binding]; other site 502025001064 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 502025001065 putative substrate binding region [chemical binding]; other site 502025001066 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025001067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025001068 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 502025001069 FecR protein; Region: FecR; pfam04773 502025001070 glucose-1-dehydrogenase; Provisional; Region: PRK08936 502025001071 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 502025001072 NAD binding site [chemical binding]; other site 502025001073 homodimer interface [polypeptide binding]; other site 502025001074 active site 502025001075 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 502025001076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025001077 Coenzyme A binding pocket [chemical binding]; other site 502025001078 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 502025001079 FAD binding domain; Region: FAD_binding_4; pfam01565 502025001080 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 502025001081 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 502025001082 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 502025001083 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025001084 putative pectinesterase; Region: PLN02432; cl01911 502025001085 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 502025001086 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025001087 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001088 active site 502025001089 ATP binding site [chemical binding]; other site 502025001090 substrate binding site [chemical binding]; other site 502025001091 activation loop (A-loop); other site 502025001092 PEGA domain; Region: PEGA; pfam08308 502025001093 TPR repeat; Region: TPR_11; pfam13414 502025001094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001095 TPR motif; other site 502025001096 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 502025001097 putative ligand binding site [chemical binding]; other site 502025001098 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 502025001099 active site 502025001100 HIGH motif; other site 502025001101 nucleotide binding site [chemical binding]; other site 502025001102 active site 502025001103 KMSKS motif; other site 502025001104 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 502025001105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025001106 S-adenosylmethionine binding site [chemical binding]; other site 502025001107 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025001108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025001109 S-adenosylmethionine binding site [chemical binding]; other site 502025001110 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 502025001111 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 502025001112 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025001113 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001114 TPR repeat; Region: TPR_11; pfam13414 502025001115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001116 binding surface 502025001117 TPR motif; other site 502025001118 PEGA domain; Region: PEGA; pfam08308 502025001119 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025001120 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001121 active site 502025001122 ATP binding site [chemical binding]; other site 502025001123 substrate binding site [chemical binding]; other site 502025001124 activation loop (A-loop); other site 502025001125 AAA ATPase domain; Region: AAA_16; pfam13191 502025001126 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 502025001127 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025001128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001129 homodimer interface [polypeptide binding]; other site 502025001130 catalytic residue [active] 502025001131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001133 TPR motif; other site 502025001134 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025001135 binding surface 502025001136 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 502025001137 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 502025001138 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 502025001139 N-acetyl-D-glucosamine binding site [chemical binding]; other site 502025001140 catalytic residue [active] 502025001141 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 502025001142 putative active site pocket [active] 502025001143 4-fold oligomerization interface [polypeptide binding]; other site 502025001144 metal binding residues [ion binding]; metal-binding site 502025001145 3-fold/trimer interface [polypeptide binding]; other site 502025001146 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 502025001147 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 502025001148 putative active site [active] 502025001149 oxyanion strand; other site 502025001150 catalytic triad [active] 502025001151 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 502025001152 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 502025001153 catalytic residues [active] 502025001154 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 502025001155 Part of AAA domain; Region: AAA_19; pfam13245 502025001156 Family description; Region: UvrD_C_2; pfam13538 502025001157 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 502025001158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 502025001159 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 502025001160 PA14 domain; Region: PA14; pfam07691 502025001161 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 502025001162 adenosine deaminase; Provisional; Region: PRK09358 502025001163 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 502025001164 active site 502025001165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025001166 S-adenosylmethionine binding site [chemical binding]; other site 502025001167 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 502025001168 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 502025001169 dimer interface [polypeptide binding]; other site 502025001170 decamer (pentamer of dimers) interface [polypeptide binding]; other site 502025001171 catalytic triad [active] 502025001172 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025001173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025001174 S-adenosylmethionine binding site [chemical binding]; other site 502025001175 SEC-C motif; Region: SEC-C; pfam02810 502025001176 argininosuccinate synthase; Provisional; Region: PRK13820 502025001177 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 502025001178 ANP binding site [chemical binding]; other site 502025001179 Substrate Binding Site II [chemical binding]; other site 502025001180 Substrate Binding Site I [chemical binding]; other site 502025001181 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 502025001182 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 502025001183 nucleotide binding site [chemical binding]; other site 502025001184 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025001185 HSP70 interaction site [polypeptide binding]; other site 502025001186 ornithine carbamoyltransferase; Provisional; Region: PRK00779 502025001187 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 502025001188 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 502025001189 acetylornithine aminotransferase; Provisional; Region: PRK02627 502025001190 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025001191 inhibitor-cofactor binding pocket; inhibition site 502025001192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001193 catalytic residue [active] 502025001194 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025001195 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025001196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025001197 Walker A motif; other site 502025001198 ATP binding site [chemical binding]; other site 502025001199 Walker B motif; other site 502025001200 arginine finger; other site 502025001201 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025001202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 502025001203 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 502025001204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 502025001205 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 502025001206 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 502025001207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025001208 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025001209 Walker A/P-loop; other site 502025001210 ATP binding site [chemical binding]; other site 502025001211 Q-loop/lid; other site 502025001212 ABC transporter signature motif; other site 502025001213 Walker B; other site 502025001214 D-loop; other site 502025001215 H-loop/switch region; other site 502025001216 Double zinc ribbon; Region: DZR; pfam12773 502025001217 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 502025001218 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 502025001219 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 502025001220 cyclase homology domain; Region: CHD; cd07302 502025001221 nucleotidyl binding site; other site 502025001222 metal binding site [ion binding]; metal-binding site 502025001223 dimer interface [polypeptide binding]; other site 502025001224 Predicted ATPase [General function prediction only]; Region: COG3899 502025001225 AAA ATPase domain; Region: AAA_16; pfam13191 502025001226 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001229 binding surface 502025001230 TPR motif; other site 502025001231 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001233 binding surface 502025001234 TPR motif; other site 502025001235 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001237 binding surface 502025001238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001239 TPR motif; other site 502025001240 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001241 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 502025001242 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 502025001243 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 502025001244 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 502025001245 Cna protein B-type domain; Region: Cna_B_2; pfam13715 502025001246 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025001247 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025001248 Thioredoxin; Region: Thioredoxin_4; pfam13462 502025001249 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 502025001250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025001251 Walker A/P-loop; other site 502025001252 ATP binding site [chemical binding]; other site 502025001253 Q-loop/lid; other site 502025001254 ABC transporter signature motif; other site 502025001255 Walker B; other site 502025001256 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 502025001257 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 502025001258 ABC-ATPase subunit interface; other site 502025001259 dimer interface [polypeptide binding]; other site 502025001260 putative PBP binding regions; other site 502025001261 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 502025001262 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 502025001263 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 502025001264 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 502025001265 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 502025001266 intersubunit interface [polypeptide binding]; other site 502025001267 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 502025001268 Predicted membrane protein [Function unknown]; Region: COG2246 502025001269 GtrA-like protein; Region: GtrA; pfam04138 502025001270 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 502025001271 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 502025001272 Ligand binding site; other site 502025001273 Putative Catalytic site; other site 502025001274 DXD motif; other site 502025001275 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 502025001276 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 502025001277 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 502025001278 nucleotide binding site [chemical binding]; other site 502025001279 putative NEF/HSP70 interaction site [polypeptide binding]; other site 502025001280 SBD interface [polypeptide binding]; other site 502025001281 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 502025001282 HSP70 interaction site [polypeptide binding]; other site 502025001283 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001284 active site 502025001285 ATP binding site [chemical binding]; other site 502025001286 substrate binding site [chemical binding]; other site 502025001287 activation loop (A-loop); other site 502025001288 PEGA domain; Region: PEGA; pfam08308 502025001289 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 502025001290 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 502025001291 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 502025001292 gamma-glutamyl kinase; Provisional; Region: PRK05429 502025001293 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 502025001294 nucleotide binding site [chemical binding]; other site 502025001295 homotetrameric interface [polypeptide binding]; other site 502025001296 putative phosphate binding site [ion binding]; other site 502025001297 putative allosteric binding site; other site 502025001298 PUA domain; Region: PUA; pfam01472 502025001299 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 502025001300 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 502025001301 putative catalytic cysteine [active] 502025001302 Oligomerisation domain; Region: Oligomerisation; pfam02410 502025001303 Cytochrome c; Region: Cytochrom_C; pfam00034 502025001304 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 502025001305 hydroxyglutarate oxidase; Provisional; Region: PRK11728 502025001306 threonine synthase; Validated; Region: PRK06260 502025001307 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 502025001308 homodimer interface [polypeptide binding]; other site 502025001309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001310 catalytic residue [active] 502025001311 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 502025001312 Na binding site [ion binding]; other site 502025001313 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 502025001314 active site 502025001315 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 502025001316 dimer interface [polypeptide binding]; other site 502025001317 non-prolyl cis peptide bond; other site 502025001318 insertion regions; other site 502025001319 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 502025001320 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 502025001321 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 502025001322 Beta-lactamase; Region: Beta-lactamase; pfam00144 502025001323 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001324 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001325 active site 502025001326 ATP binding site [chemical binding]; other site 502025001327 substrate binding site [chemical binding]; other site 502025001328 activation loop (A-loop); other site 502025001329 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 502025001330 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 502025001331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025001332 FeS/SAM binding site; other site 502025001333 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 502025001334 FG-GAP repeat; Region: FG-GAP; cl15299 502025001335 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 502025001336 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 502025001337 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 502025001338 Ferredoxin [Energy production and conversion]; Region: COG1146 502025001339 4Fe-4S binding domain; Region: Fer4_6; pfam12837 502025001340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025001341 YhhN-like protein; Region: YhhN; pfam07947 502025001342 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 502025001343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 502025001344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025001345 Coenzyme A binding pocket [chemical binding]; other site 502025001346 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 502025001347 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025001348 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 502025001349 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025001350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025001351 active site 502025001352 Methyltransferase domain; Region: Methyltransf_26; pfam13659 502025001353 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 502025001354 FAD binding domain; Region: FAD_binding_4; pfam01565 502025001355 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 502025001356 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 502025001357 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 502025001358 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 502025001359 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 502025001360 active site 502025001361 HEAT repeats; Region: HEAT_2; pfam13646 502025001362 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 502025001363 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025001364 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 502025001365 substrate binding site [chemical binding]; other site 502025001366 oxyanion hole (OAH) forming residues; other site 502025001367 trimer interface [polypeptide binding]; other site 502025001368 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025001369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025001370 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 502025001371 acyl-activating enzyme (AAE) consensus motif; other site 502025001372 putative AMP binding site [chemical binding]; other site 502025001373 putative active site [active] 502025001374 putative CoA binding site [chemical binding]; other site 502025001375 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 502025001376 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 502025001377 Na binding site [ion binding]; other site 502025001378 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 502025001379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001380 NAD(P) binding site [chemical binding]; other site 502025001381 active site 502025001382 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025001383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001384 NAD(P) binding site [chemical binding]; other site 502025001385 active site 502025001386 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025001387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 502025001388 sulfotransferase; Region: PLN02164 502025001389 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 502025001390 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 502025001391 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 502025001392 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 502025001393 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 502025001394 catalytic residue [active] 502025001395 putative FPP diphosphate binding site; other site 502025001396 putative FPP binding hydrophobic cleft; other site 502025001397 dimer interface [polypeptide binding]; other site 502025001398 putative IPP diphosphate binding site; other site 502025001399 phage shock protein A; Region: phageshock_pspA; TIGR02977 502025001400 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 502025001401 protein binding site [polypeptide binding]; other site 502025001402 PilZ domain; Region: PilZ; cl01260 502025001403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 502025001404 active site 502025001405 phosphorylation site [posttranslational modification] 502025001406 intermolecular recognition site; other site 502025001407 dimerization interface [polypeptide binding]; other site 502025001408 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001409 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001410 active site 502025001411 ATP binding site [chemical binding]; other site 502025001412 substrate binding site [chemical binding]; other site 502025001413 activation loop (A-loop); other site 502025001414 AAA ATPase domain; Region: AAA_16; pfam13191 502025001415 14-3-3 domain; Region: 14-3-3; cl02098 502025001416 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 502025001417 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025001418 dimer interface [polypeptide binding]; other site 502025001419 active site 502025001420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025001421 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 502025001422 active site 502025001423 metal binding site [ion binding]; metal-binding site 502025001424 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001425 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001426 active site 502025001427 ATP binding site [chemical binding]; other site 502025001428 substrate binding site [chemical binding]; other site 502025001429 activation loop (A-loop); other site 502025001430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001431 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025001432 binding surface 502025001433 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 502025001434 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 502025001435 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 502025001436 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 502025001437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025001438 active site 502025001439 motif I; other site 502025001440 motif II; other site 502025001441 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 502025001442 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025001443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001444 TPR motif; other site 502025001445 binding surface 502025001446 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025001447 Protein kinase domain; Region: Pkinase; pfam00069 502025001448 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001449 active site 502025001450 ATP binding site [chemical binding]; other site 502025001451 substrate binding site [chemical binding]; other site 502025001452 activation loop (A-loop); other site 502025001453 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 502025001454 UbiA prenyltransferase family; Region: UbiA; pfam01040 502025001455 Protein of unknown function (DUF420); Region: DUF420; pfam04238 502025001456 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 502025001457 biotin synthase; Region: bioB; TIGR00433 502025001458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025001459 FeS/SAM binding site; other site 502025001460 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 502025001461 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 502025001462 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 502025001463 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 502025001464 quinone interaction residues [chemical binding]; other site 502025001465 active site 502025001466 catalytic residues [active] 502025001467 FMN binding site [chemical binding]; other site 502025001468 substrate binding site [chemical binding]; other site 502025001469 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 502025001470 DTAP/Switch II; other site 502025001471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 502025001472 Domain of unknown function (DUF329); Region: DUF329; pfam03884 502025001473 PilZ domain; Region: PilZ; cl01260 502025001474 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 502025001475 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025001476 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 502025001477 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025001478 Ligand binding site; other site 502025001479 Putative Catalytic site; other site 502025001480 DXD motif; other site 502025001481 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 502025001482 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 502025001483 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025001484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025001485 Walker A motif; other site 502025001486 ATP binding site [chemical binding]; other site 502025001487 Walker B motif; other site 502025001488 arginine finger; other site 502025001489 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025001490 Protein of unknown function DUF58; Region: DUF58; pfam01882 502025001491 Aerotolerance regulator N-terminal; Region: BatA; cl06567 502025001492 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025001493 metal ion-dependent adhesion site (MIDAS); other site 502025001494 von Willebrand factor type A domain; Region: VWA_2; pfam13519 502025001495 metal ion-dependent adhesion site (MIDAS); other site 502025001496 Oxygen tolerance; Region: BatD; pfam13584 502025001497 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 502025001498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025001499 S-adenosylmethionine binding site [chemical binding]; other site 502025001500 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 502025001501 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 502025001502 Rdx family; Region: Rdx; pfam10262 502025001503 PEGA domain; Region: PEGA; pfam08308 502025001504 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 502025001505 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 502025001506 RNA binding site [nucleotide binding]; other site 502025001507 domain interface; other site 502025001508 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 502025001509 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 502025001510 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 502025001511 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 502025001512 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001513 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001514 active site 502025001515 ATP binding site [chemical binding]; other site 502025001516 substrate binding site [chemical binding]; other site 502025001517 activation loop (A-loop); other site 502025001518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025001519 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025001520 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 502025001521 Sulfatase; Region: Sulfatase; cl17466 502025001522 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 502025001523 dimerization interface [polypeptide binding]; other site 502025001524 active site 502025001525 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 502025001526 RNA binding site [nucleotide binding]; other site 502025001527 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 502025001528 RNA binding site [nucleotide binding]; other site 502025001529 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025001530 RNA binding site [nucleotide binding]; other site 502025001531 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025001532 RNA binding site [nucleotide binding]; other site 502025001533 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001534 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001535 active site 502025001536 ATP binding site [chemical binding]; other site 502025001537 substrate binding site [chemical binding]; other site 502025001538 activation loop (A-loop); other site 502025001539 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 502025001540 elongation factor G; Reviewed; Region: PRK12740 502025001541 G1 box; other site 502025001542 putative GEF interaction site [polypeptide binding]; other site 502025001543 GTP/Mg2+ binding site [chemical binding]; other site 502025001544 Switch I region; other site 502025001545 G2 box; other site 502025001546 G3 box; other site 502025001547 Switch II region; other site 502025001548 G4 box; other site 502025001549 G5 box; other site 502025001550 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 502025001551 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 502025001552 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 502025001553 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025001554 Walker A motif; other site 502025001555 ATP binding site [chemical binding]; other site 502025001556 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 502025001557 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025001558 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 502025001559 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025001560 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 502025001561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025001562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025001563 active site 502025001564 phosphorylation site [posttranslational modification] 502025001565 intermolecular recognition site; other site 502025001566 dimerization interface [polypeptide binding]; other site 502025001567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025001568 DNA binding site [nucleotide binding] 502025001569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025001570 dimer interface [polypeptide binding]; other site 502025001571 phosphorylation site [posttranslational modification] 502025001572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025001573 ATP binding site [chemical binding]; other site 502025001574 Mg2+ binding site [ion binding]; other site 502025001575 G-X-G motif; other site 502025001576 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025001577 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025001578 active site 502025001579 catalytic tetrad [active] 502025001580 Serine hydrolase; Region: Ser_hydrolase; cl17834 502025001581 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025001582 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 502025001583 cleavage site 502025001584 active site 502025001585 substrate binding sites [chemical binding]; other site 502025001586 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025001587 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025001588 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 502025001589 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 502025001590 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 502025001591 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 502025001592 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 502025001593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025001594 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025001595 active site 502025001596 catalytic tetrad [active] 502025001597 4Fe-4S binding domain; Region: Fer4_5; pfam12801 502025001598 4Fe-4S binding domain; Region: Fer4_5; pfam12801 502025001599 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 502025001600 MauM/NapG family ferredoxin-type protein; Region: mauM_napG; TIGR00397 502025001601 Uncharacterized conserved protein [Function unknown]; Region: COG2006 502025001602 Domain of unknown function (DUF362); Region: DUF362; pfam04015 502025001603 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 502025001604 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025001605 inhibitor-cofactor binding pocket; inhibition site 502025001606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025001607 catalytic residue [active] 502025001608 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 502025001609 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 502025001610 active site 502025001611 metal binding site [ion binding]; metal-binding site 502025001612 ribonuclease PH; Reviewed; Region: rph; PRK00173 502025001613 Ribonuclease PH; Region: RNase_PH_bact; cd11362 502025001614 hexamer interface [polypeptide binding]; other site 502025001615 active site 502025001616 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 502025001617 active site 502025001618 dimerization interface [polypeptide binding]; other site 502025001619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025001620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025001621 non-specific DNA binding site [nucleotide binding]; other site 502025001622 salt bridge; other site 502025001623 sequence-specific DNA binding site [nucleotide binding]; other site 502025001624 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025001625 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001626 active site 502025001627 ATP binding site [chemical binding]; other site 502025001628 substrate binding site [chemical binding]; other site 502025001629 activation loop (A-loop); other site 502025001630 AAA ATPase domain; Region: AAA_16; pfam13191 502025001631 TPR repeat; Region: TPR_11; pfam13414 502025001632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001633 binding surface 502025001634 TPR motif; other site 502025001635 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001636 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001637 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001638 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 502025001639 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025001640 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025001641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025001642 non-specific DNA binding site [nucleotide binding]; other site 502025001643 salt bridge; other site 502025001644 sequence-specific DNA binding site [nucleotide binding]; other site 502025001645 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025001646 putative active site pocket [active] 502025001647 dimerization interface [polypeptide binding]; other site 502025001648 putative catalytic residue [active] 502025001649 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025001650 excinuclease ABC, A subunit; Region: uvra; TIGR00630 502025001651 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025001652 active site 502025001653 catalytic residues [active] 502025001654 DNA binding site [nucleotide binding] 502025001655 Int/Topo IB signature motif; other site 502025001656 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025001657 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025001658 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 502025001659 catalytic residues [active] 502025001660 catalytic nucleophile [active] 502025001661 Presynaptic Site I dimer interface [polypeptide binding]; other site 502025001662 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 502025001663 Synaptic Flat tetramer interface [polypeptide binding]; other site 502025001664 Synaptic Site I dimer interface [polypeptide binding]; other site 502025001665 DNA binding site [nucleotide binding] 502025001666 Recombinase; Region: Recombinase; pfam07508 502025001667 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025001668 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 502025001669 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025001670 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001671 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001672 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001673 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001674 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001675 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001676 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001677 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 502025001678 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 502025001679 PglZ domain; Region: PglZ; pfam08665 502025001680 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 502025001681 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025001682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001683 ATP binding site [chemical binding]; other site 502025001684 putative Mg++ binding site [ion binding]; other site 502025001685 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025001686 nucleotide binding region [chemical binding]; other site 502025001687 ATP-binding site [chemical binding]; other site 502025001688 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 502025001689 catalytic site [active] 502025001690 putative active site [active] 502025001691 putative substrate binding site [chemical binding]; other site 502025001692 Domain of unknown function (DUF955); Region: DUF955; cl01076 502025001693 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 502025001694 ADP-ribose binding site [chemical binding]; other site 502025001695 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 502025001696 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 502025001697 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 502025001698 NB-ARC domain; Region: NB-ARC; pfam00931 502025001699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001701 TPR motif; other site 502025001702 binding surface 502025001703 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001704 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001706 binding surface 502025001707 TPR motif; other site 502025001708 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001709 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001711 TPR motif; other site 502025001712 binding surface 502025001713 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025001714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025001715 sequence-specific DNA binding site [nucleotide binding]; other site 502025001716 salt bridge; other site 502025001717 short chain dehydrogenase; Provisional; Region: PRK06523 502025001718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001719 NAD(P) binding site [chemical binding]; other site 502025001720 active site 502025001721 SnoaL-like domain; Region: SnoaL_2; pfam12680 502025001722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025001723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025001724 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 502025001725 putative effector binding pocket; other site 502025001726 putative dimerization interface [polypeptide binding]; other site 502025001727 Disintegrin; Region: Disintegrin; cl10507 502025001728 Disintegrin; Region: Disintegrin; cl10507 502025001729 Disintegrin; Region: Disintegrin; cl10507 502025001730 Disintegrin; Region: Disintegrin; cl10507 502025001731 Disintegrin; Region: Disintegrin; cl10507 502025001732 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025001733 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025001734 catalytic residues [active] 502025001735 catalytic nucleophile [active] 502025001736 Recombinase; Region: Recombinase; pfam07508 502025001737 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025001738 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025001739 CHC2 zinc finger; Region: zf-CHC2; cl17510 502025001740 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 502025001741 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 502025001742 active site 502025001743 metal binding site [ion binding]; metal-binding site 502025001744 interdomain interaction site; other site 502025001745 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 502025001746 protein-splicing catalytic site; other site 502025001747 thioester formation/cholesterol transfer; other site 502025001748 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 502025001749 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 502025001750 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025001751 active site 502025001752 catalytic site [active] 502025001753 substrate binding site [chemical binding]; other site 502025001754 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 502025001755 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025001756 active site 502025001757 catalytic residues [active] 502025001758 DNA binding site [nucleotide binding] 502025001759 Int/Topo IB signature motif; other site 502025001760 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 502025001761 Terminase-like family; Region: Terminase_6; pfam03237 502025001762 Phage-related protein [Function unknown]; Region: COG4695; cl01923 502025001763 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 502025001764 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 502025001765 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 502025001766 Phage capsid family; Region: Phage_capsid; pfam05065 502025001767 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 502025001768 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025001769 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 502025001770 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 502025001771 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 502025001772 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 502025001773 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 502025001774 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 502025001775 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 502025001776 phage tail protein domain; Region: tail_TIGR02242 502025001777 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 502025001778 substrate binding site [chemical binding]; other site 502025001779 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025001780 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025001781 putative active site pocket [active] 502025001782 dimerization interface [polypeptide binding]; other site 502025001783 putative catalytic residue [active] 502025001784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025001785 salt bridge; other site 502025001786 non-specific DNA binding site [nucleotide binding]; other site 502025001787 sequence-specific DNA binding site [nucleotide binding]; other site 502025001788 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025001789 phosphopeptide binding site; other site 502025001790 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001791 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001792 active site 502025001793 ATP binding site [chemical binding]; other site 502025001794 substrate binding site [chemical binding]; other site 502025001795 activation loop (A-loop); other site 502025001796 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025001797 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001798 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001799 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001800 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001801 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001802 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001803 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025001804 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025001805 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025001806 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025001807 active site 502025001808 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025001809 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025001810 active site 502025001811 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025001812 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025001813 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 502025001814 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025001815 putative NADP binding site [chemical binding]; other site 502025001816 active site 502025001817 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 502025001818 Family description; Region: VCBS; pfam13517 502025001819 Family description; Region: VCBS; pfam13517 502025001820 Family description; Region: VCBS; pfam13517 502025001821 Family description; Region: VCBS; pfam13517 502025001822 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 502025001823 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 502025001824 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025001825 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 502025001826 active site 502025001827 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025001828 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 502025001829 Phage Tail Collar Domain; Region: Collar; pfam07484 502025001830 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025001831 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025001832 catalytic residues [active] 502025001833 catalytic nucleophile [active] 502025001834 Recombinase; Region: Recombinase; pfam07508 502025001835 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025001836 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025001837 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 502025001838 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001839 ATP binding site [chemical binding]; other site 502025001840 putative Mg++ binding site [ion binding]; other site 502025001841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025001842 nucleotide binding region [chemical binding]; other site 502025001843 ATP-binding site [chemical binding]; other site 502025001844 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 502025001845 DEAD/DEAH box helicase; Region: DEAD; pfam00270 502025001846 ATP binding site [chemical binding]; other site 502025001847 DEAD_2; Region: DEAD_2; pfam06733 502025001848 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 502025001849 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 502025001850 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 502025001851 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025001852 active site 502025001853 catalytic site [active] 502025001854 substrate binding site [chemical binding]; other site 502025001855 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025001856 active site 502025001857 catalytic residues [active] 502025001858 DNA binding site [nucleotide binding] 502025001859 Int/Topo IB signature motif; other site 502025001860 Asparaginase [Amino acid transport and metabolism]; Region: COG1446 502025001861 active site 502025001862 dimer interface [polypeptide binding]; other site 502025001863 catalytic nucleophile [active] 502025001864 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025001865 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025001866 putative active site pocket [active] 502025001867 dimerization interface [polypeptide binding]; other site 502025001868 putative catalytic residue [active] 502025001869 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025001870 salt bridge; other site 502025001871 non-specific DNA binding site [nucleotide binding]; other site 502025001872 sequence-specific DNA binding site [nucleotide binding]; other site 502025001873 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025001874 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025001875 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025001876 active site 502025001877 ATP binding site [chemical binding]; other site 502025001878 substrate binding site [chemical binding]; other site 502025001879 activation loop (A-loop); other site 502025001880 AAA ATPase domain; Region: AAA_16; pfam13191 502025001881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025001882 binding surface 502025001883 TPR motif; other site 502025001884 PEGA domain; Region: PEGA; pfam08308 502025001885 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001886 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025001887 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 502025001888 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 502025001889 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001890 ATP binding site [chemical binding]; other site 502025001891 putative Mg++ binding site [ion binding]; other site 502025001892 helicase superfamily c-terminal domain; Region: HELICc; smart00490 502025001893 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 502025001894 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 502025001895 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 502025001896 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 502025001897 Family description; Region: UvrD_C_2; pfam13538 502025001898 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 502025001899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001900 ATP binding site [chemical binding]; other site 502025001901 putative Mg++ binding site [ion binding]; other site 502025001902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 502025001903 nucleotide binding region [chemical binding]; other site 502025001904 ATP-binding site [chemical binding]; other site 502025001905 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 502025001906 Divergent AAA domain; Region: AAA_4; pfam04326 502025001907 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 502025001908 Complement Clr-like EGF-like; Region: cEGF; pfam12662 502025001909 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 502025001910 Ca2+ binding site [ion binding]; other site 502025001911 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 502025001912 Ca2+ binding site [ion binding]; other site 502025001913 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025001914 HNH endonuclease; Region: HNH_2; pfam13391 502025001915 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025001916 active site 502025001917 metal binding site [ion binding]; metal-binding site 502025001918 short chain dehydrogenase; Provisional; Region: PRK06523 502025001919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001920 NAD(P) binding site [chemical binding]; other site 502025001921 active site 502025001922 SnoaL-like domain; Region: SnoaL_2; pfam12680 502025001923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025001924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025001925 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 502025001926 putative effector binding pocket; other site 502025001927 putative dimerization interface [polypeptide binding]; other site 502025001928 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025001929 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025001930 catalytic residues [active] 502025001931 catalytic nucleophile [active] 502025001932 Recombinase; Region: Recombinase; pfam07508 502025001933 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025001934 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025001935 CHC2 zinc finger; Region: zf-CHC2; cl17510 502025001936 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 502025001937 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 502025001938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025001939 ATP binding site [chemical binding]; other site 502025001940 putative Mg++ binding site [ion binding]; other site 502025001941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025001942 nucleotide binding region [chemical binding]; other site 502025001943 ATP-binding site [chemical binding]; other site 502025001944 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 502025001945 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 502025001946 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025001947 active site 502025001948 catalytic site [active] 502025001949 substrate binding site [chemical binding]; other site 502025001950 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025001951 active site 502025001952 catalytic residues [active] 502025001953 DNA binding site [nucleotide binding] 502025001954 Int/Topo IB signature motif; other site 502025001955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025001956 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 502025001957 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025001958 Radical SAM superfamily; Region: Radical_SAM; pfam04055 502025001959 FeS/SAM binding site; other site 502025001960 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 502025001961 O-methyltransferase; Region: Methyltransf_2; pfam00891 502025001962 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 502025001963 catalytic core [active] 502025001964 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025001965 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025001966 putative active site pocket [active] 502025001967 dimerization interface [polypeptide binding]; other site 502025001968 putative catalytic residue [active] 502025001969 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025001970 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 502025001971 Condensation domain; Region: Condensation; pfam00668 502025001972 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025001973 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025001974 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 502025001975 acyl-activating enzyme (AAE) consensus motif; other site 502025001976 AMP binding site [chemical binding]; other site 502025001977 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025001978 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025001979 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025001980 active site 502025001981 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025001982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001983 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025001984 NAD(P) binding site [chemical binding]; other site 502025001985 active site 502025001986 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025001987 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025001988 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025001989 active site 502025001990 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025001991 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025001992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025001993 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025001994 KR domain; Region: KR; pfam08659 502025001995 putative NADP binding site [chemical binding]; other site 502025001996 active site 502025001997 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025001998 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025001999 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002000 active site 502025002001 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025002002 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 502025002003 Enoylreductase; Region: PKS_ER; smart00829 502025002004 NAD(P) binding site [chemical binding]; other site 502025002005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025002006 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025002007 NAD(P) binding site [chemical binding]; other site 502025002008 active site 502025002009 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025002010 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002011 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025002012 active site 502025002013 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025002014 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 502025002015 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 502025002016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025002017 hypothetical protein; Provisional; Region: PRK09956 502025002018 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002019 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 502025002020 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025002021 Cytochrome P450; Region: p450; cl12078 502025002022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025002023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002024 S-adenosylmethionine binding site [chemical binding]; other site 502025002025 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 502025002026 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 502025002027 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025002028 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 502025002029 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 502025002030 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 502025002031 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 502025002032 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 502025002033 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025002034 hydrophobic ligand binding site; other site 502025002035 Cytochrome P450; Region: p450; pfam00067 502025002036 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025002037 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025002038 Cytochrome P450; Region: p450; cl12078 502025002039 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025002040 Cytochrome P450; Region: p450; cl12078 502025002041 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025002042 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025002043 catalytic residues [active] 502025002044 catalytic nucleophile [active] 502025002045 Recombinase; Region: Recombinase; pfam07508 502025002046 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002047 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002048 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 502025002049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002050 ATP binding site [chemical binding]; other site 502025002051 putative Mg++ binding site [ion binding]; other site 502025002052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002053 nucleotide binding region [chemical binding]; other site 502025002054 ATP-binding site [chemical binding]; other site 502025002055 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 502025002056 DEAD/DEAH box helicase; Region: DEAD; pfam00270 502025002057 ATP binding site [chemical binding]; other site 502025002058 DEAD_2; Region: DEAD_2; pfam06733 502025002059 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 502025002060 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 502025002061 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 502025002062 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025002063 active site 502025002064 catalytic site [active] 502025002065 substrate binding site [chemical binding]; other site 502025002066 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025002067 active site 502025002068 catalytic residues [active] 502025002069 DNA binding site [nucleotide binding] 502025002070 Int/Topo IB signature motif; other site 502025002071 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 502025002072 Terminase-like family; Region: Terminase_6; pfam03237 502025002073 Phage-related protein [Function unknown]; Region: COG4695; cl01923 502025002074 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 502025002075 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 502025002076 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 502025002077 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 502025002078 Phage capsid family; Region: Phage_capsid; pfam05065 502025002079 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 502025002080 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025002081 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 502025002082 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 502025002083 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 502025002084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 502025002085 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 502025002086 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 502025002087 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 502025002088 phage tail protein domain; Region: tail_TIGR02242 502025002089 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 502025002090 substrate binding site [chemical binding]; other site 502025002091 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025002092 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025002093 putative active site pocket [active] 502025002094 dimerization interface [polypeptide binding]; other site 502025002095 putative catalytic residue [active] 502025002096 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025002097 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002098 Bacterial SH3 domain; Region: SH3_3; pfam08239 502025002099 PGAP1-like protein; Region: PGAP1; pfam07819 502025002100 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 502025002101 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025002102 protein-splicing catalytic site; other site 502025002103 thioester formation/cholesterol transfer; other site 502025002104 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025002105 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025002106 calcium binding site 2 [ion binding]; other site 502025002107 active site 502025002108 catalytic triad [active] 502025002109 calcium binding site 1 [ion binding]; other site 502025002110 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025002111 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025002112 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025002113 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002114 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025002115 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002116 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002117 Protein kinase domain; Region: Pkinase; pfam00069 502025002118 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002119 active site 502025002120 ATP binding site [chemical binding]; other site 502025002121 substrate binding site [chemical binding]; other site 502025002122 activation loop (A-loop); other site 502025002123 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025002124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025002125 sequence-specific DNA binding site [nucleotide binding]; other site 502025002126 salt bridge; other site 502025002127 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025002128 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002129 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002130 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002131 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002132 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002133 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002134 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025002135 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025002136 catalytic residues [active] 502025002137 catalytic nucleophile [active] 502025002138 Recombinase; Region: Recombinase; pfam07508 502025002139 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002140 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002141 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 502025002142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002143 ATP binding site [chemical binding]; other site 502025002144 putative Mg++ binding site [ion binding]; other site 502025002145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002146 nucleotide binding region [chemical binding]; other site 502025002147 ATP-binding site [chemical binding]; other site 502025002148 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 502025002149 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 502025002150 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 502025002151 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 502025002152 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025002153 active site 502025002154 catalytic site [active] 502025002155 substrate binding site [chemical binding]; other site 502025002156 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025002157 metal binding site [ion binding]; metal-binding site 502025002158 N-acetyltransferase; Region: Acetyltransf_2; cl00949 502025002159 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 502025002160 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 502025002161 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 502025002162 active site 502025002163 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025002164 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025002165 putative active site pocket [active] 502025002166 dimerization interface [polypeptide binding]; other site 502025002167 putative catalytic residue [active] 502025002168 Bacterial SH3 domain; Region: SH3_3; cl17532 502025002169 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002170 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002171 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002172 active site 502025002173 ATP binding site [chemical binding]; other site 502025002174 substrate binding site [chemical binding]; other site 502025002175 activation loop (A-loop); other site 502025002176 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025002178 Walker A/P-loop; other site 502025002179 ATP binding site [chemical binding]; other site 502025002180 Q-loop/lid; other site 502025002181 ABC transporter signature motif; other site 502025002182 Walker B; other site 502025002183 H-loop/switch region; other site 502025002184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002185 binding surface 502025002186 TPR motif; other site 502025002187 PEGA domain; Region: PEGA; pfam08308 502025002188 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002189 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002190 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025002191 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 502025002192 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 502025002193 putative active site [active] 502025002194 putative NTP binding site [chemical binding]; other site 502025002195 putative nucleic acid binding site [nucleotide binding]; other site 502025002196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025002197 Integrase core domain; Region: rve; pfam00665 502025002198 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025002199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002200 Walker A motif; other site 502025002201 ATP binding site [chemical binding]; other site 502025002202 Walker B motif; other site 502025002203 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 502025002204 Uncharacterized conserved protein [Function unknown]; Region: COG4933 502025002205 Restriction endonuclease; Region: Mrr_cat; pfam04471 502025002206 Predicted ATPase [General function prediction only]; Region: COG5293 502025002207 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 502025002208 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025002209 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025002210 catalytic residues [active] 502025002211 catalytic nucleophile [active] 502025002212 Recombinase; Region: Recombinase; pfam07508 502025002213 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002214 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002215 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 502025002216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002217 ATP binding site [chemical binding]; other site 502025002218 putative Mg++ binding site [ion binding]; other site 502025002219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002220 nucleotide binding region [chemical binding]; other site 502025002221 ATP-binding site [chemical binding]; other site 502025002222 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 502025002223 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 502025002224 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 502025002225 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025002226 active site 502025002227 catalytic site [active] 502025002228 substrate binding site [chemical binding]; other site 502025002229 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025002230 active site 502025002231 catalytic residues [active] 502025002232 DNA binding site [nucleotide binding] 502025002233 Int/Topo IB signature motif; other site 502025002234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002235 S-adenosylmethionine binding site [chemical binding]; other site 502025002236 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025002237 putative active site pocket [active] 502025002238 dimerization interface [polypeptide binding]; other site 502025002239 putative catalytic residue [active] 502025002240 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002241 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 502025002242 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025002243 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025002244 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002245 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002246 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002247 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002248 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002249 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002250 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002251 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002252 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002253 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025002254 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002255 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025002256 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002257 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002258 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002259 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025002260 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025002261 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002262 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002263 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002264 active site 502025002265 ATP binding site [chemical binding]; other site 502025002266 substrate binding site [chemical binding]; other site 502025002267 activation loop (A-loop); other site 502025002268 PEGA domain; Region: PEGA; pfam08308 502025002269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002270 TPR motif; other site 502025002271 TPR repeat; Region: TPR_11; pfam13414 502025002272 binding surface 502025002273 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025002274 Uncharacterized protein family UPF0560; Region: UPF0560; pfam10577 502025002275 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025002276 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025002277 Transposase; Region: DEDD_Tnp_IS110; pfam01548 502025002278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 502025002279 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 502025002280 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002281 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002282 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025002283 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 502025002284 Integrase core domain; Region: rve; pfam00665 502025002285 Integrase core domain; Region: rve_3; pfam13683 502025002286 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002287 active site 502025002288 ATP binding site [chemical binding]; other site 502025002289 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002290 substrate binding site [chemical binding]; other site 502025002291 activation loop (A-loop); other site 502025002292 PEGA domain; Region: PEGA; pfam08308 502025002293 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025002294 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025002295 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025002296 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 502025002297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025002298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025002299 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 502025002300 substrate binding pocket [chemical binding]; other site 502025002301 dimerization interface [polypeptide binding]; other site 502025002302 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002303 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 502025002304 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025002305 putative active site pocket [active] 502025002306 dimerization interface [polypeptide binding]; other site 502025002307 putative catalytic residue [active] 502025002308 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025002309 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 502025002310 Terminase-like family; Region: Terminase_6; pfam03237 502025002311 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025002312 active site 502025002313 catalytic residues [active] 502025002314 DNA binding site [nucleotide binding] 502025002315 Int/Topo IB signature motif; other site 502025002316 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025002317 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 502025002318 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025002319 active site 502025002320 catalytic site [active] 502025002321 substrate binding site [chemical binding]; other site 502025002322 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 502025002323 DNA primase domain-containing protein; Region: PHA02415 502025002324 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 502025002325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002326 ATP binding site [chemical binding]; other site 502025002327 putative Mg++ binding site [ion binding]; other site 502025002328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002329 nucleotide binding region [chemical binding]; other site 502025002330 ATP-binding site [chemical binding]; other site 502025002331 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002332 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025002333 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025002334 catalytic residues [active] 502025002335 catalytic nucleophile [active] 502025002336 Recombinase; Region: Recombinase; pfam07508 502025002337 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002338 SEFIR domain; Region: SEFIR; pfam08357 502025002339 AAA ATPase domain; Region: AAA_16; pfam13191 502025002340 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025002341 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 502025002342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002343 Walker A motif; other site 502025002344 ATP binding site [chemical binding]; other site 502025002345 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002346 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025002347 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002348 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002349 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002350 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002351 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 502025002352 Transposase; Region: DEDD_Tnp_IS110; pfam01548 502025002353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 502025002354 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 502025002355 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002356 Transposase; Region: DEDD_Tnp_IS110; pfam01548 502025002357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 502025002358 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 502025002359 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002360 Transposase; Region: DEDD_Tnp_IS110; pfam01548 502025002361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 502025002362 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 502025002363 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002365 Walker A motif; other site 502025002366 ATP binding site [chemical binding]; other site 502025002367 Walker B motif; other site 502025002368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025002369 Integrase core domain; Region: rve; pfam00665 502025002370 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002371 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002372 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002373 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002374 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002375 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025002376 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025002377 ligand binding site [chemical binding]; other site 502025002378 flexible hinge region; other site 502025002379 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025002380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002381 S-adenosylmethionine binding site [chemical binding]; other site 502025002382 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002383 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002384 Tetratricopeptide repeat; Region: TPR_10; cl17452 502025002385 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002386 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025002388 binding surface 502025002389 TPR motif; other site 502025002390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025002391 Integrase core domain; Region: rve; pfam00665 502025002392 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025002393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002394 Walker A motif; other site 502025002395 ATP binding site [chemical binding]; other site 502025002396 Walker B motif; other site 502025002397 Bacterial Ig-like domain; Region: Big_5; pfam13205 502025002398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002399 Walker A motif; other site 502025002400 ATP binding site [chemical binding]; other site 502025002401 Walker B motif; other site 502025002402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025002403 Integrase core domain; Region: rve; pfam00665 502025002404 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025002405 Condensation domain; Region: Condensation; pfam00668 502025002406 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025002407 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002408 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025002409 Condensation domain; Region: Condensation; pfam00668 502025002410 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025002411 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002412 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025002413 acyl-activating enzyme (AAE) consensus motif; other site 502025002414 AMP binding site [chemical binding]; other site 502025002415 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025002416 Condensation domain; Region: Condensation; pfam00668 502025002417 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025002418 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002419 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025002420 acyl-activating enzyme (AAE) consensus motif; other site 502025002421 AMP binding site [chemical binding]; other site 502025002422 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025002423 Condensation domain; Region: Condensation; pfam00668 502025002424 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025002425 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025002426 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 502025002427 acyl-activating enzyme (AAE) consensus motif; other site 502025002428 AMP binding site [chemical binding]; other site 502025002429 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025002430 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 502025002431 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 502025002432 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 502025002433 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 502025002434 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 502025002435 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; cl17241 502025002436 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 502025002437 active site 502025002438 catalytic residues [active] 502025002439 metal binding site [ion binding]; metal-binding site 502025002440 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 502025002441 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 502025002442 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 502025002443 homodimer interface [polypeptide binding]; other site 502025002444 substrate-cofactor binding pocket; other site 502025002445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025002446 catalytic residue [active] 502025002447 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 502025002448 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025002449 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 502025002450 acyl-activating enzyme (AAE) consensus motif; other site 502025002451 active site 502025002452 AMP binding site [chemical binding]; other site 502025002453 CoA binding site [chemical binding]; other site 502025002454 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002455 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025002456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025002457 non-specific DNA binding site [nucleotide binding]; other site 502025002458 salt bridge; other site 502025002459 sequence-specific DNA binding site [nucleotide binding]; other site 502025002460 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002461 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002462 active site 502025002463 ATP binding site [chemical binding]; other site 502025002464 substrate binding site [chemical binding]; other site 502025002465 activation loop (A-loop); other site 502025002466 AAA ATPase domain; Region: AAA_16; pfam13191 502025002467 TPR repeat; Region: TPR_11; pfam13414 502025002468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025002469 binding surface 502025002470 TPR motif; other site 502025002471 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002472 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002474 Walker A motif; other site 502025002475 ATP binding site [chemical binding]; other site 502025002476 Walker B motif; other site 502025002477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025002478 Integrase core domain; Region: rve; pfam00665 502025002479 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002480 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002481 active site 502025002482 ATP binding site [chemical binding]; other site 502025002483 substrate binding site [chemical binding]; other site 502025002484 activation loop (A-loop); other site 502025002485 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002486 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002487 active site 502025002488 ATP binding site [chemical binding]; other site 502025002489 substrate binding site [chemical binding]; other site 502025002490 activation loop (A-loop); other site 502025002491 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002493 TPR motif; other site 502025002494 binding surface 502025002495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002496 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002497 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002499 binding surface 502025002500 TPR motif; other site 502025002501 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002502 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002503 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002504 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002505 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002506 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002507 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002508 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002509 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002510 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002511 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002512 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002513 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002514 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002515 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002516 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002517 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002518 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002519 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002520 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002521 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002522 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002523 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002524 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002525 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002526 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025002527 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025002528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002529 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025002530 Walker A motif; other site 502025002531 ATP binding site [chemical binding]; other site 502025002532 Walker B motif; other site 502025002533 arginine finger; other site 502025002534 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025002535 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025002536 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 502025002537 PEGA domain; Region: PEGA; pfam08308 502025002538 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 502025002539 Sel1-like repeats; Region: SEL1; smart00671 502025002540 Sel1-like repeats; Region: SEL1; smart00671 502025002541 Sel1-like repeats; Region: SEL1; smart00671 502025002542 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 502025002543 Sel1-like repeats; Region: SEL1; smart00671 502025002544 Sel1-like repeats; Region: SEL1; smart00671 502025002545 Sel1-like repeats; Region: SEL1; smart00671 502025002546 Sel1-like repeats; Region: SEL1; smart00671 502025002547 Sel1 repeat; Region: Sel1; cl02723 502025002548 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 502025002549 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 502025002550 putative active site [active] 502025002551 putative NTP binding site [chemical binding]; other site 502025002552 putative nucleic acid binding site [nucleotide binding]; other site 502025002553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002554 Walker A motif; other site 502025002555 ATP binding site [chemical binding]; other site 502025002556 Walker B motif; other site 502025002557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025002558 Integrase core domain; Region: rve; pfam00665 502025002559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025002560 Walker A motif; other site 502025002561 ATP binding site [chemical binding]; other site 502025002562 Walker B motif; other site 502025002563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 502025002564 Transposase; Region: HTH_Tnp_1; pfam01527 502025002565 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002566 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002569 binding surface 502025002570 TPR motif; other site 502025002571 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025002572 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025002573 Transposase; Region: HTH_Tnp_1; pfam01527 502025002574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 502025002575 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025002576 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025002577 Caspase domain; Region: Peptidase_C14; pfam00656 502025002578 CHAT domain; Region: CHAT; cl17868 502025002579 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002580 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002581 active site 502025002582 ATP binding site [chemical binding]; other site 502025002583 substrate binding site [chemical binding]; other site 502025002584 activation loop (A-loop); other site 502025002585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002587 binding surface 502025002588 TPR motif; other site 502025002589 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002590 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002591 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 502025002592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025002593 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 502025002594 ABC1 family; Region: ABC1; cl17513 502025002595 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 502025002596 ABC1 family; Region: ABC1; cl17513 502025002597 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025002598 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 502025002599 substrate binding site [chemical binding]; other site 502025002600 oxyanion hole (OAH) forming residues; other site 502025002601 trimer interface [polypeptide binding]; other site 502025002602 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025002603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002604 S-adenosylmethionine binding site [chemical binding]; other site 502025002605 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 502025002606 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002607 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025002608 active site 502025002609 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002610 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025002611 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 502025002612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002613 S-adenosylmethionine binding site [chemical binding]; other site 502025002614 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025002615 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002616 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025002617 active site 502025002618 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002619 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025002620 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025002621 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025002622 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025002623 putative NADP binding site [chemical binding]; other site 502025002624 active site 502025002625 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025002626 FkbH-like domain; Region: FkbH; TIGR01686 502025002627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025002628 active site 502025002629 motif I; other site 502025002630 motif II; other site 502025002631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025002632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025002633 active site 502025002634 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 502025002635 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 502025002636 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025002637 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025002638 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002639 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025002640 active site 502025002641 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002642 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025002643 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 502025002644 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 502025002645 dimer interface [polypeptide binding]; other site 502025002646 active site 502025002647 acyl carrier protein; Validated; Region: PRK07117 502025002648 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 502025002649 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025002650 substrate binding site [chemical binding]; other site 502025002651 oxyanion hole (OAH) forming residues; other site 502025002652 trimer interface [polypeptide binding]; other site 502025002653 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 502025002654 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002655 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 502025002656 active site 502025002657 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025002658 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025002659 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002660 active site 502025002661 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025002662 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025002663 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025002664 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025002665 putative NADP binding site [chemical binding]; other site 502025002666 active site 502025002667 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025002668 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002669 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025002670 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025002671 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 502025002672 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025002673 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 502025002674 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 502025002675 active site 502025002676 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025002677 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025002678 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025002679 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025002680 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025002681 active site 502025002682 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025002683 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025002684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025002685 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 502025002686 Enoylreductase; Region: PKS_ER; smart00829 502025002687 NAD(P) binding site [chemical binding]; other site 502025002688 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025002689 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025002690 putative NADP binding site [chemical binding]; other site 502025002691 active site 502025002692 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025002693 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 502025002694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 502025002695 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 502025002696 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025002697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025002698 non-specific DNA binding site [nucleotide binding]; other site 502025002699 salt bridge; other site 502025002700 sequence-specific DNA binding site [nucleotide binding]; other site 502025002701 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002702 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002703 active site 502025002704 ATP binding site [chemical binding]; other site 502025002705 substrate binding site [chemical binding]; other site 502025002706 activation loop (A-loop); other site 502025002707 AAA ATPase domain; Region: AAA_16; pfam13191 502025002708 TPR repeat; Region: TPR_11; pfam13414 502025002709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025002710 binding surface 502025002711 TPR motif; other site 502025002712 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025002713 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 502025002714 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002715 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025002716 Nuclease-related domain; Region: NERD; pfam08378 502025002717 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 502025002718 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002719 active site 502025002720 ATP binding site [chemical binding]; other site 502025002721 substrate binding site [chemical binding]; other site 502025002722 activation loop (A-loop); other site 502025002723 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002724 active site 502025002725 ATP binding site [chemical binding]; other site 502025002726 substrate binding site [chemical binding]; other site 502025002727 activation loop (A-loop); other site 502025002728 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 502025002729 Methyltransferase domain; Region: Methyltransf_26; pfam13659 502025002730 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 502025002731 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025002732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002733 ATP binding site [chemical binding]; other site 502025002734 putative Mg++ binding site [ion binding]; other site 502025002735 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002736 nucleotide binding region [chemical binding]; other site 502025002737 ATP-binding site [chemical binding]; other site 502025002738 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002739 Annexin; Region: Annexin; cl02574 502025002740 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002741 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002742 active site 502025002743 ATP binding site [chemical binding]; other site 502025002744 substrate binding site [chemical binding]; other site 502025002745 activation loop (A-loop); other site 502025002746 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025002747 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 502025002748 catalytic residues [active] 502025002749 catalytic nucleophile [active] 502025002750 Recombinase; Region: Recombinase; pfam07508 502025002751 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025002752 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025002753 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 502025002754 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002755 ATP binding site [chemical binding]; other site 502025002756 putative Mg++ binding site [ion binding]; other site 502025002757 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002758 nucleotide binding region [chemical binding]; other site 502025002759 ATP-binding site [chemical binding]; other site 502025002760 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025002761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025002762 non-specific DNA binding site [nucleotide binding]; other site 502025002763 salt bridge; other site 502025002764 sequence-specific DNA binding site [nucleotide binding]; other site 502025002765 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025002766 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002767 active site 502025002768 ATP binding site [chemical binding]; other site 502025002769 substrate binding site [chemical binding]; other site 502025002770 activation loop (A-loop); other site 502025002771 AAA ATPase domain; Region: AAA_16; pfam13191 502025002772 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025002773 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002774 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002775 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002776 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002777 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002778 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002779 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025002780 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 502025002781 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 502025002782 PglZ domain; Region: PglZ; pfam08665 502025002783 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 502025002784 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025002785 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025002786 ATP binding site [chemical binding]; other site 502025002787 putative Mg++ binding site [ion binding]; other site 502025002788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025002789 nucleotide binding region [chemical binding]; other site 502025002790 ATP-binding site [chemical binding]; other site 502025002791 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 502025002792 catalytic site [active] 502025002793 putative active site [active] 502025002794 putative substrate binding site [chemical binding]; other site 502025002795 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025002796 PhoD-like phosphatase; Region: PhoD; pfam09423 502025002797 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025002798 putative active site [active] 502025002799 putative metal binding site [ion binding]; other site 502025002800 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025002801 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 502025002802 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 502025002803 CoenzymeA binding site [chemical binding]; other site 502025002804 subunit interaction site [polypeptide binding]; other site 502025002805 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 502025002806 MgtC family; Region: MgtC; pfam02308 502025002807 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 502025002808 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 502025002809 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 502025002810 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 502025002811 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 502025002812 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025002813 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025002814 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025002815 ligand binding site [chemical binding]; other site 502025002816 flexible hinge region; other site 502025002817 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025002818 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025002819 ligand binding site [chemical binding]; other site 502025002820 flexible hinge region; other site 502025002821 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 502025002822 substrate binding pocket [chemical binding]; other site 502025002823 substrate-Mg2+ binding site; other site 502025002824 aspartate-rich region 1; other site 502025002825 active site lid residues [active] 502025002826 aspartate-rich region 2; other site 502025002827 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 502025002828 substrate binding pocket [chemical binding]; other site 502025002829 substrate-Mg2+ binding site; other site 502025002830 aspartate-rich region 1; other site 502025002831 aspartate-rich region 2; other site 502025002832 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025002833 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025002834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025002835 DNA binding residues [nucleotide binding] 502025002836 Protein kinase; unclassified specificity; Region: STYKc; smart00221 502025002837 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002838 active site 502025002839 ATP binding site [chemical binding]; other site 502025002840 substrate binding site [chemical binding]; other site 502025002841 activation loop (A-loop); other site 502025002842 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002843 CHAT domain; Region: CHAT; pfam12770 502025002844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002845 binding surface 502025002846 TPR motif; other site 502025002847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002848 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002850 binding surface 502025002851 TPR motif; other site 502025002852 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025002854 binding surface 502025002855 TPR motif; other site 502025002856 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002857 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002858 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025002859 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 502025002860 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025002861 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 502025002862 putative hydrophobic ligand binding site [chemical binding]; other site 502025002863 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025002864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025002865 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025002866 DNA binding residues [nucleotide binding] 502025002867 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 502025002868 Transcriptional regulators [Transcription]; Region: MarR; COG1846 502025002869 MarR family; Region: MarR; pfam01047 502025002870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 502025002871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025002872 Coenzyme A binding pocket [chemical binding]; other site 502025002873 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002874 active site 502025002875 ATP binding site [chemical binding]; other site 502025002876 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025002877 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025002878 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025002879 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025002880 active site 502025002881 ATP binding site [chemical binding]; other site 502025002882 substrate binding site [chemical binding]; other site 502025002883 activation loop (A-loop); other site 502025002884 AAA ATPase domain; Region: AAA_16; pfam13191 502025002885 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025002886 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025002887 structural tetrad; other site 502025002888 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025002889 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025002890 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 502025002891 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025002892 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 502025002893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025002894 FeS/SAM binding site; other site 502025002895 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 502025002896 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 502025002897 active site 502025002898 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 502025002899 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025002900 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025002901 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025002902 hypothetical protein; Provisional; Region: PRK07588 502025002903 hypothetical protein; Provisional; Region: PRK07236 502025002904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025002905 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025002906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025002907 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 502025002908 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025002909 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 502025002910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025002911 Walker A/P-loop; other site 502025002912 ATP binding site [chemical binding]; other site 502025002913 Q-loop/lid; other site 502025002914 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 502025002915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025002916 Walker A/P-loop; other site 502025002917 ATP binding site [chemical binding]; other site 502025002918 Q-loop/lid; other site 502025002919 ABC transporter signature motif; other site 502025002920 Walker B; other site 502025002921 D-loop; other site 502025002922 H-loop/switch region; other site 502025002923 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 502025002924 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 502025002925 Peptidase M15; Region: Peptidase_M15_3; cl01194 502025002926 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025002927 Methyltransferase domain; Region: Methyltransf_12; pfam08242 502025002928 S-adenosylmethionine binding site [chemical binding]; other site 502025002929 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 502025002930 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 502025002931 glycosyltransferase, MGT family; Region: MGT; TIGR01426 502025002932 active site 502025002933 TDP-binding site; other site 502025002934 acceptor substrate-binding pocket; other site 502025002935 homodimer interface [polypeptide binding]; other site 502025002936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025002937 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025002938 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 502025002939 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025002940 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 502025002941 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025002942 catalytic residue [active] 502025002943 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 502025002944 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 502025002945 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 502025002946 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 502025002947 catalytic triad [active] 502025002948 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025002949 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025002950 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025002951 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025002952 N-terminal domain interface [polypeptide binding]; other site 502025002953 dimer interface [polypeptide binding]; other site 502025002954 substrate binding pocket (H-site) [chemical binding]; other site 502025002955 Radical SAM superfamily; Region: Radical_SAM; pfam04055 502025002956 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025002957 FeS/SAM binding site; other site 502025002958 SCP-2 sterol transfer family; Region: SCP2; pfam02036 502025002959 Cupin-like domain; Region: Cupin_8; pfam13621 502025002960 B12 binding domain; Region: B12-binding; pfam02310 502025002961 B12 binding site [chemical binding]; other site 502025002962 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 502025002963 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025002964 FeS/SAM binding site; other site 502025002965 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025002966 Cytochrome P450; Region: p450; cl12078 502025002967 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 502025002968 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 502025002969 tyrosine decarboxylase; Region: PLN02880 502025002970 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025002971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025002972 catalytic residue [active] 502025002973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025002974 S-adenosylmethionine binding site [chemical binding]; other site 502025002975 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025002976 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025002977 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025002978 catalytic residue [active] 502025002979 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 502025002980 RHS Repeat; Region: RHS_repeat; cl11982 502025002981 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025002982 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025002983 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025002984 protein-splicing catalytic site; other site 502025002985 thioester formation/cholesterol transfer; other site 502025002986 Pretoxin HINT domain; Region: PT-HINT; pfam07591 502025002987 SET domain; Region: SET; pfam00856 502025002988 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025002989 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 502025002990 acyl-activating enzyme (AAE) consensus motif; other site 502025002991 AMP binding site [chemical binding]; other site 502025002992 active site 502025002993 CoA binding site [chemical binding]; other site 502025002994 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025002995 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 502025002996 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025002997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025002998 catalytic residue [active] 502025002999 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 502025003000 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 502025003001 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 502025003002 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 502025003003 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 502025003004 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 502025003005 CRISPR-associated protein; Region: DUF3692; pfam12469 502025003006 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 502025003007 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 502025003008 CHAT domain; Region: CHAT; cl17868 502025003009 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025003010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025003011 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025003012 DNA binding residues [nucleotide binding] 502025003013 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003014 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003015 active site 502025003016 ATP binding site [chemical binding]; other site 502025003017 substrate binding site [chemical binding]; other site 502025003018 activation loop (A-loop); other site 502025003019 Caspase domain; Region: Peptidase_C14; pfam00656 502025003020 Restriction endonuclease; Region: Mrr_cat; pfam04471 502025003021 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025003022 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 502025003023 putative active site [active] 502025003024 putative metal binding site [ion binding]; other site 502025003025 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025003026 NB-ARC domain; Region: NB-ARC; pfam00931 502025003027 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003028 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003029 structural tetrad; other site 502025003030 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003031 structural tetrad; other site 502025003032 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 502025003033 Protein of unknown function (DUF524); Region: DUF524; pfam04411 502025003034 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 502025003035 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 502025003036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025003037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025003038 WHG domain; Region: WHG; pfam13305 502025003039 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003040 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025003041 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003042 short chain dehydrogenase; Provisional; Region: PRK06172 502025003043 classical (c) SDRs; Region: SDR_c; cd05233 502025003044 NAD(P) binding site [chemical binding]; other site 502025003045 active site 502025003046 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003047 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025003048 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003049 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025003050 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025003051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025003052 catalytic residue [active] 502025003053 hypothetical protein; Provisional; Region: PRK06834 502025003054 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 502025003055 NB-ARC domain; Region: NB-ARC; pfam00931 502025003056 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003057 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003058 structural tetrad; other site 502025003059 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003060 structural tetrad; other site 502025003061 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025003063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025003064 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025003065 putative effector binding pocket; other site 502025003066 dimerization interface [polypeptide binding]; other site 502025003067 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 502025003068 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025003069 active site 502025003070 metal binding site [ion binding]; metal-binding site 502025003071 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 502025003072 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 502025003073 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 502025003074 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 502025003075 putative sugar binding site [chemical binding]; other site 502025003076 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 502025003077 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 502025003078 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 502025003079 active site 502025003080 TDP-binding site; other site 502025003081 acceptor substrate-binding pocket; other site 502025003082 homodimer interface [polypeptide binding]; other site 502025003083 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 502025003084 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 502025003085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025003086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025003087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025003088 active site 502025003089 catalytic tetrad [active] 502025003090 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 502025003091 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025003092 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025003093 Response regulator receiver domain; Region: Response_reg; pfam00072 502025003094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025003095 active site 502025003096 phosphorylation site [posttranslational modification] 502025003097 intermolecular recognition site; other site 502025003098 dimerization interface [polypeptide binding]; other site 502025003099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 502025003100 NMT1/THI5 like; Region: NMT1; pfam09084 502025003101 substrate binding pocket [chemical binding]; other site 502025003102 membrane-bound complex binding site; other site 502025003103 hinge residues; other site 502025003104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025003105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025003106 dimerization interface [polypeptide binding]; other site 502025003107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025003108 dimer interface [polypeptide binding]; other site 502025003109 phosphorylation site [posttranslational modification] 502025003110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025003111 ATP binding site [chemical binding]; other site 502025003112 Mg2+ binding site [ion binding]; other site 502025003113 G-X-G motif; other site 502025003114 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 502025003115 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 502025003116 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025003117 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025003118 catalytic loop [active] 502025003119 iron binding site [ion binding]; other site 502025003120 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025003121 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025003122 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025003123 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025003124 H+ Antiporter protein; Region: 2A0121; TIGR00900 502025003125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025003126 putative substrate translocation pore; other site 502025003127 MbtH-like protein; Region: MbtH; cl01279 502025003128 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 502025003129 Glutamine amidotransferase class-I; Region: GATase; pfam00117 502025003130 glutamine binding [chemical binding]; other site 502025003131 catalytic triad [active] 502025003132 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 502025003133 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 502025003134 chorismate binding enzyme; Region: Chorismate_bind; cl10555 502025003135 acyl-CoA synthetase; Validated; Region: PRK05850 502025003136 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 502025003137 acyl-activating enzyme (AAE) consensus motif; other site 502025003138 active site 502025003139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025003140 Condensation domain; Region: Condensation; pfam00668 502025003141 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025003142 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003143 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025003144 acyl-activating enzyme (AAE) consensus motif; other site 502025003145 AMP binding site [chemical binding]; other site 502025003146 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025003147 Condensation domain; Region: Condensation; pfam00668 502025003148 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025003149 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003150 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025003151 acyl-activating enzyme (AAE) consensus motif; other site 502025003152 AMP binding site [chemical binding]; other site 502025003153 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025003154 Condensation domain; Region: Condensation; pfam00668 502025003155 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025003156 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003157 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025003158 acyl-activating enzyme (AAE) consensus motif; other site 502025003159 AMP binding site [chemical binding]; other site 502025003160 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025003161 Condensation domain; Region: Condensation; pfam00668 502025003162 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025003163 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003164 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025003165 acyl-activating enzyme (AAE) consensus motif; other site 502025003166 AMP binding site [chemical binding]; other site 502025003167 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025003168 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 502025003169 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025003170 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025003171 acyl-activating enzyme (AAE) consensus motif; other site 502025003172 AMP binding site [chemical binding]; other site 502025003173 active site 502025003174 CoA binding site [chemical binding]; other site 502025003175 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025003176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003177 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 502025003178 NAD(P) binding site [chemical binding]; other site 502025003179 Trm112p-like protein; Region: Trm112p; cl01066 502025003180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025003181 S-adenosylmethionine binding site [chemical binding]; other site 502025003182 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 502025003183 hydroxyglutarate oxidase; Provisional; Region: PRK11728 502025003184 Chorismate mutase type II; Region: CM_2; cl00693 502025003185 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 502025003186 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 502025003187 putative ligand binding site [chemical binding]; other site 502025003188 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 502025003189 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 502025003190 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003191 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003192 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003193 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003194 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003195 PLD-like domain; Region: PLDc_2; pfam13091 502025003196 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025003197 putative active site [active] 502025003198 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025003199 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025003200 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025003201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025003202 Walker A motif; other site 502025003203 ATP binding site [chemical binding]; other site 502025003204 Walker B motif; other site 502025003205 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025003206 metal ion-dependent adhesion site (MIDAS); other site 502025003207 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 502025003208 putative hydrophobic ligand binding site [chemical binding]; other site 502025003209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025003210 dimerization interface [polypeptide binding]; other site 502025003211 putative DNA binding site [nucleotide binding]; other site 502025003212 putative Zn2+ binding site [ion binding]; other site 502025003213 EGF domain; Region: EGF_3; pfam12947 502025003214 EGF domain; Region: EGF_3; pfam12947 502025003215 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025003216 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025003217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025003218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025003219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025003220 S-adenosylmethionine binding site [chemical binding]; other site 502025003221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025003222 Coenzyme A binding pocket [chemical binding]; other site 502025003223 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 502025003224 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 502025003225 Ca2+ binding site [ion binding]; other site 502025003226 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025003227 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003228 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003229 active site 502025003230 ATP binding site [chemical binding]; other site 502025003231 substrate binding site [chemical binding]; other site 502025003232 activation loop (A-loop); other site 502025003233 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003234 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003235 active site 502025003236 ATP binding site [chemical binding]; other site 502025003237 substrate binding site [chemical binding]; other site 502025003238 activation loop (A-loop); other site 502025003239 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025003240 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025003241 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025003242 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025003243 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025003244 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025003245 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025003246 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025003247 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025003248 phosphopeptide binding site; other site 502025003249 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025003250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025003251 Walker A motif; other site 502025003252 ATP binding site [chemical binding]; other site 502025003253 Walker B motif; other site 502025003254 arginine finger; other site 502025003255 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025003256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025003257 S-adenosylmethionine binding site [chemical binding]; other site 502025003258 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003259 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003260 active site 502025003261 ATP binding site [chemical binding]; other site 502025003262 substrate binding site [chemical binding]; other site 502025003263 activation loop (A-loop); other site 502025003264 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 502025003265 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025003266 DNA binding residues [nucleotide binding] 502025003267 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 502025003268 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 502025003269 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 502025003270 CheB methylesterase; Region: CheB_methylest; pfam01339 502025003271 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025003272 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025003273 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 502025003274 PAS domain; Region: PAS_10; pfam13596 502025003275 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 502025003276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025003277 putative active site [active] 502025003278 heme pocket [chemical binding]; other site 502025003279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025003280 putative active site [active] 502025003281 heme pocket [chemical binding]; other site 502025003282 PAS fold; Region: PAS_4; pfam08448 502025003283 PAS fold; Region: PAS_3; pfam08447 502025003284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025003285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025003286 dimer interface [polypeptide binding]; other site 502025003287 phosphorylation site [posttranslational modification] 502025003288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025003289 ATP binding site [chemical binding]; other site 502025003290 Mg2+ binding site [ion binding]; other site 502025003291 G-X-G motif; other site 502025003292 Response regulator receiver domain; Region: Response_reg; pfam00072 502025003293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025003294 active site 502025003295 phosphorylation site [posttranslational modification] 502025003296 intermolecular recognition site; other site 502025003297 dimerization interface [polypeptide binding]; other site 502025003298 Amidohydrolase; Region: Amidohydro_2; pfam04909 502025003299 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 502025003300 putative C-terminal domain interface [polypeptide binding]; other site 502025003301 putative GSH binding site (G-site) [chemical binding]; other site 502025003302 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025003303 putative dimer interface [polypeptide binding]; other site 502025003304 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 502025003305 dimer interface [polypeptide binding]; other site 502025003306 N-terminal domain interface [polypeptide binding]; other site 502025003307 putative substrate binding pocket (H-site) [chemical binding]; other site 502025003308 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 502025003309 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 502025003310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025003311 FeS/SAM binding site; other site 502025003312 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 502025003313 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 502025003314 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 502025003315 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 502025003316 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003317 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003318 active site 502025003319 ATP binding site [chemical binding]; other site 502025003320 substrate binding site [chemical binding]; other site 502025003321 activation loop (A-loop); other site 502025003322 AAA ATPase domain; Region: AAA_16; pfam13191 502025003323 WD40 repeats; Region: WD40; smart00320 502025003324 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003325 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003326 structural tetrad; other site 502025003327 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003328 structural tetrad; other site 502025003329 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003330 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003331 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003332 active site 502025003333 ATP binding site [chemical binding]; other site 502025003334 substrate binding site [chemical binding]; other site 502025003335 activation loop (A-loop); other site 502025003336 AAA ATPase domain; Region: AAA_16; pfam13191 502025003337 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003338 structural tetrad; other site 502025003339 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003340 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003341 structural tetrad; other site 502025003342 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 502025003343 ABC1 family; Region: ABC1; cl17513 502025003344 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025003345 AMP binding site [chemical binding]; other site 502025003346 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003347 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003348 active site 502025003349 ATP binding site [chemical binding]; other site 502025003350 substrate binding site [chemical binding]; other site 502025003351 activation loop (A-loop); other site 502025003352 AAA ATPase domain; Region: AAA_16; pfam13191 502025003353 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 502025003354 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 502025003355 ligand binding site [chemical binding]; other site 502025003356 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 502025003357 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 502025003358 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 502025003359 Ligand Binding Site [chemical binding]; other site 502025003360 Molecular Tunnel; other site 502025003361 short chain dehydrogenase; Provisional; Region: PRK06914 502025003362 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 502025003363 NADP binding site [chemical binding]; other site 502025003364 active site 502025003365 steroid binding site; other site 502025003366 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025003367 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 502025003368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025003369 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003370 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003371 active site 502025003372 ATP binding site [chemical binding]; other site 502025003373 substrate binding site [chemical binding]; other site 502025003374 activation loop (A-loop); other site 502025003375 AAA ATPase domain; Region: AAA_16; pfam13191 502025003376 WD domain, G-beta repeat; Region: WD40; pfam00400 502025003377 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003378 structural tetrad; other site 502025003379 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003380 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003381 structural tetrad; other site 502025003382 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003383 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003384 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003385 active site 502025003386 ATP binding site [chemical binding]; other site 502025003387 substrate binding site [chemical binding]; other site 502025003388 activation loop (A-loop); other site 502025003389 AAA ATPase domain; Region: AAA_16; pfam13191 502025003390 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003391 structural tetrad; other site 502025003392 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003393 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003394 structural tetrad; other site 502025003395 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003396 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003397 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003398 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003399 active site 502025003400 ATP binding site [chemical binding]; other site 502025003401 substrate binding site [chemical binding]; other site 502025003402 activation loop (A-loop); other site 502025003403 AAA ATPase domain; Region: AAA_16; pfam13191 502025003404 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003405 structural tetrad; other site 502025003406 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003407 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025003408 structural tetrad; other site 502025003409 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003410 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 502025003411 oxyanion hole [active] 502025003412 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 502025003413 catalytic triad [active] 502025003414 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 502025003415 dinuclear metal binding motif [ion binding]; other site 502025003416 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025003417 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025003418 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 502025003419 MarR family; Region: MarR; pfam01047 502025003420 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 502025003421 homotrimer interaction site [polypeptide binding]; other site 502025003422 putative active site [active] 502025003423 Protein of unknown function (DUF808); Region: DUF808; pfam05661 502025003424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025003425 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 502025003426 RibD C-terminal domain; Region: RibD_C; cl17279 502025003427 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 502025003428 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 502025003429 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025003430 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025003431 active site 502025003432 catalytic tetrad [active] 502025003433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003434 NADH(P)-binding; Region: NAD_binding_10; pfam13460 502025003435 NAD(P) binding site [chemical binding]; other site 502025003436 active site 502025003437 YhhN-like protein; Region: YhhN; pfam07947 502025003438 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025003439 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 502025003440 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025003441 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 502025003442 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025003443 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003444 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003445 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025003446 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003447 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025003448 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 502025003449 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 502025003450 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025003451 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025003452 ligand binding site [chemical binding]; other site 502025003453 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025003454 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025003455 ligand binding site [chemical binding]; other site 502025003456 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025003457 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025003458 phosphopeptide binding site; other site 502025003459 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025003460 metal binding site [ion binding]; metal-binding site 502025003461 active site 502025003462 I-site; other site 502025003463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025003464 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025003465 Walker A motif; other site 502025003466 ATP binding site [chemical binding]; other site 502025003467 Walker B motif; other site 502025003468 arginine finger; other site 502025003469 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025003470 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003471 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003472 active site 502025003473 ATP binding site [chemical binding]; other site 502025003474 substrate binding site [chemical binding]; other site 502025003475 activation loop (A-loop); other site 502025003476 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025003477 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025003478 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025003479 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025003480 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025003481 DTW domain; Region: DTW; cl01221 502025003482 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025003483 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 502025003484 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025003485 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025003486 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025003487 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025003488 catalytic residues [active] 502025003489 EamA-like transporter family; Region: EamA; pfam00892 502025003490 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 502025003491 EamA-like transporter family; Region: EamA; pfam00892 502025003492 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003493 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025003494 structural tetrad; other site 502025003495 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025003496 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 502025003497 aromatic chitin/cellulose binding site residues [chemical binding]; other site 502025003498 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 502025003499 Glyco_18 domain; Region: Glyco_18; smart00636 502025003500 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 502025003501 active site 502025003502 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 502025003503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 502025003504 DNA-binding site [nucleotide binding]; DNA binding site 502025003505 UTRA domain; Region: UTRA; pfam07702 502025003506 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 502025003507 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 502025003508 putative active site [active] 502025003509 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 502025003510 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 502025003511 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 502025003512 active site 502025003513 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 502025003514 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 502025003515 HPr interaction site; other site 502025003516 glycerol kinase (GK) interaction site [polypeptide binding]; other site 502025003517 active site 502025003518 phosphorylation site [posttranslational modification] 502025003519 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 502025003520 dimerization domain swap beta strand [polypeptide binding]; other site 502025003521 regulatory protein interface [polypeptide binding]; other site 502025003522 active site 502025003523 regulatory phosphorylation site [posttranslational modification]; other site 502025003524 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 502025003525 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 502025003526 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 502025003527 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 502025003528 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 502025003529 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 502025003530 active site 502025003531 dimer interface [polypeptide binding]; other site 502025003532 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 502025003533 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 502025003534 dimer interface [polypeptide binding]; other site 502025003535 active site 502025003536 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 502025003537 dimer interface [polypeptide binding]; other site 502025003538 active site 502025003539 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 502025003540 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 502025003541 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 502025003542 active site turn [active] 502025003543 phosphorylation site [posttranslational modification] 502025003544 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 502025003545 sugar binding site [chemical binding]; other site 502025003546 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 502025003547 beta-galactosidase; Region: BGL; TIGR03356 502025003548 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 502025003549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025003550 dimer interface [polypeptide binding]; other site 502025003551 conserved gate region; other site 502025003552 putative PBP binding loops; other site 502025003553 ABC-ATPase subunit interface; other site 502025003554 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 502025003555 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 502025003556 Walker A/P-loop; other site 502025003557 ATP binding site [chemical binding]; other site 502025003558 Q-loop/lid; other site 502025003559 ABC transporter signature motif; other site 502025003560 Walker B; other site 502025003561 D-loop; other site 502025003562 H-loop/switch region; other site 502025003563 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 502025003564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 502025003565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025003566 dimer interface [polypeptide binding]; other site 502025003567 conserved gate region; other site 502025003568 putative PBP binding loops; other site 502025003569 ABC-ATPase subunit interface; other site 502025003570 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 502025003571 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 502025003572 Walker A/P-loop; other site 502025003573 ATP binding site [chemical binding]; other site 502025003574 Q-loop/lid; other site 502025003575 ABC transporter signature motif; other site 502025003576 Walker B; other site 502025003577 D-loop; other site 502025003578 H-loop/switch region; other site 502025003579 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 502025003580 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 502025003581 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 502025003582 substrate binding site [chemical binding]; other site 502025003583 Transcriptional regulators [Transcription]; Region: PurR; COG1609 502025003584 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 502025003585 DNA binding site [nucleotide binding] 502025003586 domain linker motif; other site 502025003587 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 502025003588 dimerization interface [polypeptide binding]; other site 502025003589 ligand binding site [chemical binding]; other site 502025003590 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 502025003591 SpaB C-terminal domain; Region: SpaB_C; pfam14028 502025003592 SpaB C-terminal domain; Region: SpaB_C; pfam14028 502025003593 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 502025003594 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 502025003595 active site 502025003596 zinc binding site [ion binding]; other site 502025003597 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 502025003598 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 502025003599 metal binding triad [ion binding]; metal-binding site 502025003600 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 502025003601 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 502025003602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025003603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025003604 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025003605 putative effector binding pocket; other site 502025003606 dimerization interface [polypeptide binding]; other site 502025003607 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 502025003608 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025003609 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025003610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025003611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025003612 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003613 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003614 active site 502025003615 ATP binding site [chemical binding]; other site 502025003616 substrate binding site [chemical binding]; other site 502025003617 activation loop (A-loop); other site 502025003618 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003619 TPR repeat; Region: TPR_11; pfam13414 502025003620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025003621 TPR motif; other site 502025003622 binding surface 502025003623 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025003626 TPR motif; other site 502025003627 binding surface 502025003628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025003630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025003631 non-specific DNA binding site [nucleotide binding]; other site 502025003632 salt bridge; other site 502025003633 sequence-specific DNA binding site [nucleotide binding]; other site 502025003634 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003635 Protein kinase domain; Region: Pkinase; pfam00069 502025003636 active site 502025003637 ATP binding site [chemical binding]; other site 502025003638 substrate binding site [chemical binding]; other site 502025003639 activation loop (A-loop); other site 502025003640 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 502025003641 Family description; Region: VCBS; pfam13517 502025003642 Family description; Region: VCBS; pfam13517 502025003643 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 502025003644 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025003645 RHS Repeat; Region: RHS_repeat; pfam05593 502025003646 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025003647 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 502025003648 Beta-lactamase; Region: Beta-lactamase; pfam00144 502025003649 hypothetical protein; Provisional; Region: PRK00967 502025003650 FIST N domain; Region: FIST; pfam08495 502025003651 Uncharacterized conserved protein [Function unknown]; Region: COG3287 502025003652 FIST C domain; Region: FIST_C; pfam10442 502025003653 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025003654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025003655 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 502025003656 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025003657 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025003658 DNA binding residues [nucleotide binding] 502025003659 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 502025003661 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 502025003662 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003663 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003664 active site 502025003665 ATP binding site [chemical binding]; other site 502025003666 substrate binding site [chemical binding]; other site 502025003667 activation loop (A-loop); other site 502025003668 PEGA domain; Region: PEGA; pfam08308 502025003669 PEGA domain; Region: PEGA; pfam08308 502025003670 PEGA domain; Region: PEGA; pfam08308 502025003671 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003672 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003673 active site 502025003674 ATP binding site [chemical binding]; other site 502025003675 substrate binding site [chemical binding]; other site 502025003676 activation loop (A-loop); other site 502025003677 PEGA domain; Region: PEGA; pfam08308 502025003678 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003679 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003680 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025003681 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025003682 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003683 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003684 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003685 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003686 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003687 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003688 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025003689 Cupin; Region: Cupin_6; pfam12852 502025003690 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025003691 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025003692 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025003693 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 502025003694 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 502025003695 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 502025003696 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 502025003697 Baseplate J-like protein; Region: Baseplate_J; cl01294 502025003698 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 502025003699 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 502025003700 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 502025003701 amidase catalytic site [active] 502025003702 Zn binding residues [ion binding]; other site 502025003703 substrate binding site [chemical binding]; other site 502025003704 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 502025003705 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 502025003706 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 502025003707 classical (c) SDRs; Region: SDR_c; cd05233 502025003708 NAD(P) binding site [chemical binding]; other site 502025003709 active site 502025003710 acyl transferase; Provisional; Region: luxD; PRK13604 502025003711 transcriptional regulator; Provisional; Region: PRK10632 502025003712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025003713 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025003714 putative effector binding pocket; other site 502025003715 dimerization interface [polypeptide binding]; other site 502025003716 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 502025003717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025003718 Stage II sporulation protein; Region: SpoIID; pfam08486 502025003719 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025003720 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 502025003721 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025003722 HEAT repeats; Region: HEAT_2; pfam13646 502025003723 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 502025003724 HEAT repeats; Region: HEAT_2; pfam13646 502025003725 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 502025003726 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 502025003727 putative active site [active] 502025003728 putative NTP binding site [chemical binding]; other site 502025003729 putative nucleic acid binding site [nucleotide binding]; other site 502025003730 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 502025003731 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025003732 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 502025003733 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 502025003734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025003735 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003736 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003737 active site 502025003738 ATP binding site [chemical binding]; other site 502025003739 substrate binding site [chemical binding]; other site 502025003740 activation loop (A-loop); other site 502025003741 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 502025003742 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025003743 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025003744 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025003745 phosphopeptide binding site; other site 502025003746 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025003747 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003748 active site 502025003749 ATP binding site [chemical binding]; other site 502025003750 substrate binding site [chemical binding]; other site 502025003751 activation loop (A-loop); other site 502025003752 Protein of unknown function (DUF692); Region: DUF692; cl01263 502025003753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025003754 Walker A motif; other site 502025003755 ATP binding site [chemical binding]; other site 502025003756 Walker B motif; other site 502025003757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025003758 Integrase core domain; Region: rve; pfam00665 502025003759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 502025003760 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 502025003761 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 502025003762 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003763 active site 502025003764 ATP binding site [chemical binding]; other site 502025003765 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025003766 substrate binding site [chemical binding]; other site 502025003767 activation loop (A-loop); other site 502025003768 AAA ATPase domain; Region: AAA_16; pfam13191 502025003769 Ferritin-like; Region: Ferritin-like; pfam12902 502025003770 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 502025003771 putative cation:proton antiport protein; Provisional; Region: PRK10669 502025003772 AAA domain; Region: AAA_33; pfam13671 502025003773 RNA ligase; Region: RNA_ligase; pfam09414 502025003774 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025003775 Methyltransferase domain; Region: Methyltransf_11; pfam08241 502025003776 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 502025003777 Protein kinase domain; Region: Pkinase; pfam00069 502025003778 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025003779 active site 502025003780 substrate binding site [chemical binding]; other site 502025003781 ATP binding site [chemical binding]; other site 502025003782 activation loop (A-loop); other site 502025003783 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025003784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025003785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 502025003786 DNA binding residues [nucleotide binding] 502025003787 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 502025003788 Caspase domain; Region: Peptidase_C14; pfam00656 502025003789 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025003790 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025003791 Isochorismatase family; Region: Isochorismatase; pfam00857 502025003792 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 502025003793 catalytic triad [active] 502025003794 conserved cis-peptide bond; other site 502025003795 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 502025003796 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 502025003797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 502025003798 Integrase core domain; Region: rve; pfam00665 502025003799 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 502025003800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025003801 FeS/SAM binding site; other site 502025003802 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 502025003803 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 502025003804 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 502025003805 putative sugar binding sites [chemical binding]; other site 502025003806 Q-X-W motif; other site 502025003807 Beta/Gamma crystallin; Region: Crystall; cl02528 502025003808 Beta/Gamma crystallin; Region: Crystall; cl02528 502025003809 Inositol 1,4,5-trisphosphate/ryanodine receptor; Region: Ins145_P3_rec; pfam08709 502025003810 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 502025003811 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025003812 B12 binding site [chemical binding]; other site 502025003813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025003814 ABC transporter signature motif; other site 502025003815 D-loop; other site 502025003816 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 502025003817 SnoaL-like domain; Region: SnoaL_2; pfam12680 502025003818 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 502025003819 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 502025003820 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 502025003821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025003822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025003823 Cytochrome c; Region: Cytochrom_C; cl11414 502025003824 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 502025003825 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 502025003826 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 502025003827 GXWXG protein; Region: GXWXG; pfam14231 502025003828 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 502025003829 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 502025003830 MarR family; Region: MarR; pfam01047 502025003831 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 502025003832 Flagellin N-methylase; Region: FliB; pfam03692 502025003833 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 502025003834 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 502025003835 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 502025003836 active site 502025003837 nucleophile elbow; other site 502025003838 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025003839 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025003840 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 502025003841 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 502025003842 FMN binding site [chemical binding]; other site 502025003843 active site 502025003844 substrate binding site [chemical binding]; other site 502025003845 catalytic residue [active] 502025003846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025003847 LysR family transcriptional regulator; Provisional; Region: PRK14997 502025003848 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025003849 putative effector binding pocket; other site 502025003850 dimerization interface [polypeptide binding]; other site 502025003851 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 502025003852 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025003853 NAD binding site [chemical binding]; other site 502025003854 homodimer interface [polypeptide binding]; other site 502025003855 homotetramer interface [polypeptide binding]; other site 502025003856 active site 502025003857 Phosphotransferase enzyme family; Region: APH; pfam01636 502025003858 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 502025003859 putative active site [active] 502025003860 putative substrate binding site [chemical binding]; other site 502025003861 ATP binding site [chemical binding]; other site 502025003862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025003863 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025003864 active site 502025003865 enoyl-CoA hydratase; Provisional; Region: PRK06688 502025003866 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025003867 substrate binding site [chemical binding]; other site 502025003868 oxyanion hole (OAH) forming residues; other site 502025003869 trimer interface [polypeptide binding]; other site 502025003870 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025003871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025003872 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 502025003873 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025003874 dimer interface [polypeptide binding]; other site 502025003875 active site 502025003876 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 502025003877 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025003878 substrate binding site [chemical binding]; other site 502025003879 oxyanion hole (OAH) forming residues; other site 502025003880 trimer interface [polypeptide binding]; other site 502025003881 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025003882 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025003883 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025003884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025003885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025003886 active site 502025003887 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 502025003888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025003889 substrate binding site [chemical binding]; other site 502025003890 oxyanion hole (OAH) forming residues; other site 502025003891 trimer interface [polypeptide binding]; other site 502025003892 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025003893 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025003894 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025003895 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025003896 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025003897 active site 502025003898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025003899 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 502025003900 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 502025003901 active site 502025003902 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 502025003903 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 502025003904 catalytic Zn binding site [ion binding]; other site 502025003905 NAD binding site [chemical binding]; other site 502025003906 structural Zn binding site [ion binding]; other site 502025003907 GXWXG protein; Region: GXWXG; pfam14231 502025003908 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 502025003909 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 502025003910 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025003911 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 502025003912 acyl-activating enzyme (AAE) consensus motif; other site 502025003913 acyl-activating enzyme (AAE) consensus motif; other site 502025003914 putative AMP binding site [chemical binding]; other site 502025003915 putative active site [active] 502025003916 CoA binding site [chemical binding]; other site 502025003917 putative CoA binding site [chemical binding]; other site 502025003918 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 502025003919 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 502025003920 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 502025003921 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 502025003922 active site 502025003923 Zn binding site [ion binding]; other site 502025003924 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025003925 Actin; Region: ACTIN; smart00268 502025003926 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 502025003927 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 502025003928 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 502025003929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025003930 motif II; other site 502025003931 oxidase reductase; Provisional; Region: PTZ00273 502025003932 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 502025003933 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 502025003934 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 502025003935 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 502025003936 metal binding site [ion binding]; metal-binding site 502025003937 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025003938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025003939 S-adenosylmethionine binding site [chemical binding]; other site 502025003940 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 502025003941 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 502025003942 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 502025003943 [2Fe-2S] cluster binding site [ion binding]; other site 502025003944 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025003945 hydrophobic ligand binding site; other site 502025003946 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025003947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003948 NAD(P) binding site [chemical binding]; other site 502025003949 active site 502025003950 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 502025003951 IPT/TIG domain; Region: TIG; pfam01833 502025003952 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 502025003953 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 502025003954 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025003955 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 502025003956 rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150 502025003957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025003958 NADH(P)-binding; Region: NAD_binding_10; pfam13460 502025003959 NAD(P) binding site [chemical binding]; other site 502025003960 active site 502025003961 tetracycline repressor protein TetR; Provisional; Region: PRK13756 502025003962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025003963 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 502025003964 Predicted ATPase [General function prediction only]; Region: COG4637 502025003965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025003966 Walker A/P-loop; other site 502025003967 ATP binding site [chemical binding]; other site 502025003968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025003969 ABC transporter signature motif; other site 502025003970 Walker B; other site 502025003971 D-loop; other site 502025003972 H-loop/switch region; other site 502025003973 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 502025003974 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 502025003975 putative ligand binding site [chemical binding]; other site 502025003976 putative NAD binding site [chemical binding]; other site 502025003977 catalytic site [active] 502025003978 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 502025003979 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 502025003980 putative NAD(P) binding site [chemical binding]; other site 502025003981 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025003982 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 502025003983 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025003984 active site 502025003985 CoA binding site [chemical binding]; other site 502025003986 AMP binding site [chemical binding]; other site 502025003987 Thioesterase domain; Region: Thioesterase; pfam00975 502025003988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025003989 NRDE protein; Region: NRDE; cl01315 502025003990 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025003991 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025003992 ligand binding site [chemical binding]; other site 502025003993 flexible hinge region; other site 502025003994 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 502025003995 putative switch regulator; other site 502025003996 non-specific DNA interactions [nucleotide binding]; other site 502025003997 DNA binding site [nucleotide binding] 502025003998 sequence specific DNA binding site [nucleotide binding]; other site 502025003999 putative cAMP binding site [chemical binding]; other site 502025004000 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 502025004001 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 502025004002 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 502025004003 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 502025004004 UreF; Region: UreF; pfam01730 502025004005 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 502025004006 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 502025004007 dimer interface [polypeptide binding]; other site 502025004008 catalytic residues [active] 502025004009 urease subunit alpha; Reviewed; Region: ureC; PRK13207 502025004010 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 502025004011 subunit interactions [polypeptide binding]; other site 502025004012 active site 502025004013 flap region; other site 502025004014 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 502025004015 gamma-beta subunit interface [polypeptide binding]; other site 502025004016 alpha-beta subunit interface [polypeptide binding]; other site 502025004017 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 502025004018 alpha-gamma subunit interface [polypeptide binding]; other site 502025004019 beta-gamma subunit interface [polypeptide binding]; other site 502025004020 UreD urease accessory protein; Region: UreD; pfam01774 502025004021 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025004022 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004023 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004024 active site 502025004025 ATP binding site [chemical binding]; other site 502025004026 substrate binding site [chemical binding]; other site 502025004027 activation loop (A-loop); other site 502025004028 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025004029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004030 active site 502025004031 phosphorylation site [posttranslational modification] 502025004032 intermolecular recognition site; other site 502025004033 dimerization interface [polypeptide binding]; other site 502025004034 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 502025004035 CPxP motif; other site 502025004036 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 502025004037 CPxP motif; other site 502025004038 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 502025004039 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004040 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004041 active site 502025004042 ATP binding site [chemical binding]; other site 502025004043 substrate binding site [chemical binding]; other site 502025004044 activation loop (A-loop); other site 502025004045 Uncharacterized conserved protein [Function unknown]; Region: COG1262 502025004046 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025004047 Erythromycin esterase; Region: Erythro_esteras; cl17110 502025004048 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 502025004049 putative active site [active] 502025004050 putative CoA binding site [chemical binding]; other site 502025004051 nudix motif; other site 502025004052 metal binding site [ion binding]; metal-binding site 502025004053 Disintegrin; Region: Disintegrin; cl10507 502025004054 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025004055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025004056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025004057 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025004058 putative effector binding pocket; other site 502025004059 dimerization interface [polypeptide binding]; other site 502025004060 SnoaL-like domain; Region: SnoaL_4; pfam13577 502025004061 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 502025004062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004063 NAD(P) binding site [chemical binding]; other site 502025004064 active site 502025004065 CHAT domain; Region: CHAT; cl17868 502025004066 cyclase homology domain; Region: CHD; cd07302 502025004067 metal binding site [ion binding]; metal-binding site 502025004068 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025004069 phosphopeptide binding site; other site 502025004070 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025004071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025004072 Walker A motif; other site 502025004073 ATP binding site [chemical binding]; other site 502025004074 Walker B motif; other site 502025004075 arginine finger; other site 502025004076 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025004077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004079 active site 502025004080 ATP binding site [chemical binding]; other site 502025004081 substrate binding site [chemical binding]; other site 502025004082 activation loop (A-loop); other site 502025004083 Thrombospondin C-terminal region; Region: TSP_C; pfam05735 502025004084 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025004085 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025004086 ligand binding site [chemical binding]; other site 502025004087 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004088 active site 502025004089 ATP binding site [chemical binding]; other site 502025004090 substrate binding site [chemical binding]; other site 502025004091 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004092 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 502025004093 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025004094 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 502025004095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025004096 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025004097 DNA binding residues [nucleotide binding] 502025004098 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025004099 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025004100 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 502025004101 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025004102 Annexin; Region: Annexin; pfam00191 502025004103 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 502025004104 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 502025004105 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 502025004106 putative active site [active] 502025004107 putative FMN binding site [chemical binding]; other site 502025004108 putative substrate binding site [chemical binding]; other site 502025004109 putative catalytic residue [active] 502025004110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025004111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025004112 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 502025004113 putative homodimer interface [polypeptide binding]; other site 502025004114 putative homotetramer interface [polypeptide binding]; other site 502025004115 putative allosteric switch controlling residues; other site 502025004116 putative metal binding site [ion binding]; other site 502025004117 putative homodimer-homodimer interface [polypeptide binding]; other site 502025004118 YHS domain; Region: YHS; pfam04945 502025004119 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 502025004120 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 502025004121 Soluble P-type ATPase [General function prediction only]; Region: COG4087 502025004122 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025004123 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 502025004124 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025004125 HEAT repeats; Region: HEAT_2; pfam13646 502025004126 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 502025004127 acyl-CoA synthetase; Validated; Region: PRK05850 502025004128 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 502025004129 acyl-activating enzyme (AAE) consensus motif; other site 502025004130 active site 502025004131 H+ Antiporter protein; Region: 2A0121; TIGR00900 502025004132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025004133 putative substrate translocation pore; other site 502025004134 Condensation domain; Region: Condensation; pfam00668 502025004135 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025004136 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025004137 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025004138 acyl-activating enzyme (AAE) consensus motif; other site 502025004139 AMP binding site [chemical binding]; other site 502025004140 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004141 peptide synthase; Provisional; Region: PRK12316 502025004142 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025004143 acyl-activating enzyme (AAE) consensus motif; other site 502025004144 AMP binding site [chemical binding]; other site 502025004145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004146 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 502025004147 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025004148 acyl-activating enzyme (AAE) consensus motif; other site 502025004149 AMP binding site [chemical binding]; other site 502025004150 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004151 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025004152 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025004153 acyl-activating enzyme (AAE) consensus motif; other site 502025004154 AMP binding site [chemical binding]; other site 502025004155 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004156 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 502025004157 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025004158 acyl-activating enzyme (AAE) consensus motif; other site 502025004159 AMP binding site [chemical binding]; other site 502025004160 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004161 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 502025004162 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025004163 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025004164 acyl-activating enzyme (AAE) consensus motif; other site 502025004165 AMP binding site [chemical binding]; other site 502025004166 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004167 Condensation domain; Region: Condensation; pfam00668 502025004168 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025004169 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025004170 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025004171 acyl-activating enzyme (AAE) consensus motif; other site 502025004172 AMP binding site [chemical binding]; other site 502025004173 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004174 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025004175 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025004176 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025004177 active site 502025004178 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025004179 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025004180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004181 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025004182 inhibitor-cofactor binding pocket; inhibition site 502025004183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025004184 catalytic residue [active] 502025004185 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 502025004186 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 502025004187 Condensation domain; Region: Condensation; pfam00668 502025004188 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025004189 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025004190 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025004191 acyl-activating enzyme (AAE) consensus motif; other site 502025004192 AMP binding site [chemical binding]; other site 502025004193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004194 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 502025004195 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 502025004196 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025004197 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025004198 phosphopeptide binding site; other site 502025004199 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025004200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025004201 Walker A motif; other site 502025004202 ATP binding site [chemical binding]; other site 502025004203 Walker B motif; other site 502025004204 arginine finger; other site 502025004205 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004206 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004207 active site 502025004208 ATP binding site [chemical binding]; other site 502025004209 substrate binding site [chemical binding]; other site 502025004210 activation loop (A-loop); other site 502025004211 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004212 active site 502025004213 ATP binding site [chemical binding]; other site 502025004214 substrate binding site [chemical binding]; other site 502025004215 activation loop (A-loop); other site 502025004216 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025004217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025004218 binding surface 502025004219 TPR motif; other site 502025004220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 502025004221 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025004222 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 502025004223 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 502025004224 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 502025004225 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 502025004226 PYR/PP interface [polypeptide binding]; other site 502025004227 dimer interface [polypeptide binding]; other site 502025004228 TPP binding site [chemical binding]; other site 502025004229 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 502025004230 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 502025004231 TPP-binding site [chemical binding]; other site 502025004232 dimer interface [polypeptide binding]; other site 502025004233 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 502025004234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025004235 catalytic residue [active] 502025004236 Protein of unknown function (DUF692); Region: DUF692; cl01263 502025004237 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025004238 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025004239 acyl-activating enzyme (AAE) consensus motif; other site 502025004240 AMP binding site [chemical binding]; other site 502025004241 active site 502025004242 CoA binding site [chemical binding]; other site 502025004243 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 502025004244 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025004245 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025004246 catalytic residue [active] 502025004247 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 502025004248 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 502025004249 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 502025004250 active site 502025004251 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 502025004252 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025004253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025004254 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 502025004255 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 502025004256 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 502025004257 active site 502025004258 Ubiquitin-like proteins; Region: UBQ; cl00155 502025004259 charged pocket; other site 502025004260 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 502025004261 intermolecular salt bridges; other site 502025004262 calcium mediated ligand binding site; other site 502025004263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 502025004264 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025004265 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025004266 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025004267 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 502025004268 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 502025004269 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 502025004270 active site 502025004271 homodimer interface [polypeptide binding]; other site 502025004272 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 502025004273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025004274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025004275 homodimer interface [polypeptide binding]; other site 502025004276 catalytic residue [active] 502025004277 polyphosphate kinase; Provisional; Region: PRK05443 502025004278 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 502025004279 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 502025004280 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 502025004281 putative domain interface [polypeptide binding]; other site 502025004282 putative active site [active] 502025004283 catalytic site [active] 502025004284 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025004285 putative active site [active] 502025004286 catalytic site [active] 502025004287 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025004288 TIGR02646 family protein; Region: TIGR02646 502025004289 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 502025004290 AAA domain; Region: AAA_23; pfam13476 502025004291 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 502025004292 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 502025004293 aspartate kinase; Reviewed; Region: PRK06635 502025004294 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 502025004295 putative catalytic residues [active] 502025004296 putative nucleotide binding site [chemical binding]; other site 502025004297 putative aspartate binding site [chemical binding]; other site 502025004298 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 502025004299 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 502025004300 active site 502025004301 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 502025004302 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 502025004303 homodimer interface [polypeptide binding]; other site 502025004304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025004305 catalytic residue [active] 502025004306 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025004307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025004308 ATP binding site [chemical binding]; other site 502025004309 putative Mg++ binding site [ion binding]; other site 502025004310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025004311 nucleotide binding region [chemical binding]; other site 502025004312 ATP-binding site [chemical binding]; other site 502025004313 PAS fold; Region: PAS_4; pfam08448 502025004314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025004315 putative active site [active] 502025004316 heme pocket [chemical binding]; other site 502025004317 PAS domain S-box; Region: sensory_box; TIGR00229 502025004318 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025004319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025004320 putative active site [active] 502025004321 heme pocket [chemical binding]; other site 502025004322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025004323 dimer interface [polypeptide binding]; other site 502025004324 phosphorylation site [posttranslational modification] 502025004325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004326 ATP binding site [chemical binding]; other site 502025004327 Mg2+ binding site [ion binding]; other site 502025004328 G-X-G motif; other site 502025004329 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004331 active site 502025004332 phosphorylation site [posttranslational modification] 502025004333 intermolecular recognition site; other site 502025004334 dimerization interface [polypeptide binding]; other site 502025004335 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 502025004336 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 502025004337 Amidohydrolase; Region: Amidohydro_2; pfam04909 502025004338 active site 502025004339 DNA helicase II; Region: uvrD; TIGR01075 502025004340 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 502025004341 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025004342 active site 502025004343 Zn binding site [ion binding]; other site 502025004344 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 502025004345 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 502025004346 nudix motif; other site 502025004347 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 502025004348 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 502025004349 putative ligand binding site [chemical binding]; other site 502025004350 putative NAD binding site [chemical binding]; other site 502025004351 catalytic site [active] 502025004352 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 502025004353 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025004354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004355 active site 502025004356 phosphorylation site [posttranslational modification] 502025004357 intermolecular recognition site; other site 502025004358 dimerization interface [polypeptide binding]; other site 502025004359 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025004360 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025004361 ligand binding site [chemical binding]; other site 502025004362 Trehalose utilisation; Region: ThuA; pfam06283 502025004363 Pirin-related protein [General function prediction only]; Region: COG1741 502025004364 Pirin; Region: Pirin; pfam02678 502025004365 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 502025004366 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 502025004367 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 502025004368 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 502025004369 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 502025004370 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 502025004371 hexamer interface [polypeptide binding]; other site 502025004372 Walker A motif; other site 502025004373 ATP binding site [chemical binding]; other site 502025004374 Walker B motif; other site 502025004375 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004376 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004377 active site 502025004378 ATP binding site [chemical binding]; other site 502025004379 substrate binding site [chemical binding]; other site 502025004380 activation loop (A-loop); other site 502025004381 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004382 PEGA domain; Region: PEGA; pfam08308 502025004383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025004384 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025004385 binding surface 502025004386 TPR motif; other site 502025004387 PEGA domain; Region: PEGA; pfam08308 502025004388 PEGA domain; Region: PEGA; pfam08308 502025004389 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 502025004390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025004391 AAA domain; Region: AAA_23; pfam13476 502025004392 Walker A/P-loop; other site 502025004393 ATP binding site [chemical binding]; other site 502025004394 Q-loop/lid; other site 502025004395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025004396 Walker B; other site 502025004397 D-loop; other site 502025004398 H-loop/switch region; other site 502025004399 exonuclease subunit SbcD; Provisional; Region: PRK10966 502025004400 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 502025004401 active site 502025004402 metal binding site [ion binding]; metal-binding site 502025004403 DNA binding site [nucleotide binding] 502025004404 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 502025004405 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025004406 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 502025004407 catalytic site [active] 502025004408 Thioredoxin; Region: Thioredoxin_4; cl17273 502025004409 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025004410 HipA N-terminal domain; Region: Couple_hipA; pfam13657 502025004411 HipA-like N-terminal domain; Region: HipA_N; pfam07805 502025004412 HipA-like C-terminal domain; Region: HipA_C; pfam07804 502025004413 Uncharacterized conserved protein [Function unknown]; Region: COG1479 502025004414 Protein of unknown function DUF262; Region: DUF262; pfam03235 502025004415 Uncharacterized conserved protein [Function unknown]; Region: COG3472 502025004416 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 502025004417 active site 502025004418 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 502025004419 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025004420 active site 502025004421 substrate binding sites [chemical binding]; other site 502025004422 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 502025004423 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 502025004424 FMN binding site [chemical binding]; other site 502025004425 active site 502025004426 catalytic residues [active] 502025004427 substrate binding site [chemical binding]; other site 502025004428 putative glutathione S-transferase; Provisional; Region: PRK10357 502025004429 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 502025004430 putative C-terminal domain interface [polypeptide binding]; other site 502025004431 putative GSH binding site (G-site) [chemical binding]; other site 502025004432 putative dimer interface [polypeptide binding]; other site 502025004433 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 502025004434 dimer interface [polypeptide binding]; other site 502025004435 N-terminal domain interface [polypeptide binding]; other site 502025004436 putative substrate binding pocket (H-site) [chemical binding]; other site 502025004437 AAA domain; Region: AAA_23; pfam13476 502025004438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025004439 Walker A/P-loop; other site 502025004440 ATP binding site [chemical binding]; other site 502025004441 AAA domain; Region: AAA_21; pfam13304 502025004442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025004443 ABC transporter signature motif; other site 502025004444 Walker B; other site 502025004445 D-loop; other site 502025004446 H-loop/switch region; other site 502025004447 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 502025004448 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 502025004449 active site 502025004450 HIGH motif; other site 502025004451 KMSKS motif; other site 502025004452 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 502025004453 tRNA binding surface [nucleotide binding]; other site 502025004454 anticodon binding site; other site 502025004455 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 502025004456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025004457 binding surface 502025004458 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025004459 TPR motif; other site 502025004460 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025004461 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 502025004462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025004463 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 502025004464 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 502025004465 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 502025004466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025004467 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025004468 Sulfatase; Region: Sulfatase; cl17466 502025004469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025004470 dimerization interface [polypeptide binding]; other site 502025004471 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 502025004472 cyclase homology domain; Region: CHD; cd07302 502025004473 nucleotidyl binding site; other site 502025004474 metal binding site [ion binding]; metal-binding site 502025004475 dimer interface [polypeptide binding]; other site 502025004476 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 502025004477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025004478 putative substrate translocation pore; other site 502025004479 POT family; Region: PTR2; cl17359 502025004480 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 502025004481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004482 active site 502025004483 phosphorylation site [posttranslational modification] 502025004484 intermolecular recognition site; other site 502025004485 dimerization interface [polypeptide binding]; other site 502025004486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025004487 DNA binding residues [nucleotide binding] 502025004488 dimerization interface [polypeptide binding]; other site 502025004489 PAS fold; Region: PAS_4; pfam08448 502025004490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 502025004491 Histidine kinase; Region: HisKA_3; pfam07730 502025004492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004493 ATP binding site [chemical binding]; other site 502025004494 Mg2+ binding site [ion binding]; other site 502025004495 G-X-G motif; other site 502025004496 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 502025004497 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 502025004498 ATP-binding site [chemical binding]; other site 502025004499 Sugar specificity; other site 502025004500 Pyrimidine base specificity; other site 502025004501 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025004502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004503 NAD(P) binding site [chemical binding]; other site 502025004504 active site 502025004505 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 502025004506 RNA methyltransferase, RsmE family; Region: TIGR00046 502025004507 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025004508 active site 502025004509 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 502025004510 ATP-binding site [chemical binding]; other site 502025004511 Gluconate-6-phosphate binding site [chemical binding]; other site 502025004512 Shikimate kinase; Region: SKI; pfam01202 502025004513 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 502025004514 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025004515 active site 502025004516 N-formylglutamate amidohydrolase; Region: FGase; cl01522 502025004517 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025004518 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 502025004519 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025004520 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 502025004521 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025004522 carboxyltransferase (CT) interaction site; other site 502025004523 biotinylation site [posttranslational modification]; other site 502025004524 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 502025004525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025004526 ATP binding site [chemical binding]; other site 502025004527 putative Mg++ binding site [ion binding]; other site 502025004528 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 502025004529 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 502025004530 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 502025004531 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 502025004532 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 502025004533 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 502025004534 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 502025004535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004536 NAD(P) binding site [chemical binding]; other site 502025004537 active site 502025004538 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004539 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004540 active site 502025004541 ATP binding site [chemical binding]; other site 502025004542 substrate binding site [chemical binding]; other site 502025004543 activation loop (A-loop); other site 502025004544 Predicted ATPase [General function prediction only]; Region: COG3899 502025004545 AAA ATPase domain; Region: AAA_16; pfam13191 502025004546 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 502025004547 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025004548 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 502025004549 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 502025004550 iron-sulfur cluster [ion binding]; other site 502025004551 [2Fe-2S] cluster binding site [ion binding]; other site 502025004552 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025004553 hydrophobic ligand binding site; other site 502025004554 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025004555 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025004556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025004557 Carboxylesterase family; Region: COesterase; pfam00135 502025004558 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 502025004559 substrate binding pocket [chemical binding]; other site 502025004560 catalytic triad [active] 502025004561 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025004562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004563 active site 502025004564 phosphorylation site [posttranslational modification] 502025004565 intermolecular recognition site; other site 502025004566 dimerization interface [polypeptide binding]; other site 502025004567 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025004568 DNA binding site [nucleotide binding] 502025004569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025004570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004571 ATP binding site [chemical binding]; other site 502025004572 Mg2+ binding site [ion binding]; other site 502025004573 G-X-G motif; other site 502025004574 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004575 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004576 active site 502025004577 ATP binding site [chemical binding]; other site 502025004578 substrate binding site [chemical binding]; other site 502025004579 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004580 substrate binding site [chemical binding]; other site 502025004581 activation loop (A-loop); other site 502025004582 activation loop (A-loop); other site 502025004583 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 502025004584 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025004585 catalytic triad [active] 502025004586 alanine racemase; Reviewed; Region: alr; PRK00053 502025004587 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 502025004588 active site 502025004589 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025004590 dimer interface [polypeptide binding]; other site 502025004591 substrate binding site [chemical binding]; other site 502025004592 catalytic residues [active] 502025004593 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 502025004594 Permease; Region: Permease; pfam02405 502025004595 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 502025004596 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 502025004597 Walker A/P-loop; other site 502025004598 ATP binding site [chemical binding]; other site 502025004599 Q-loop/lid; other site 502025004600 ABC transporter signature motif; other site 502025004601 Walker B; other site 502025004602 D-loop; other site 502025004603 H-loop/switch region; other site 502025004604 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 502025004605 mce related protein; Region: MCE; pfam02470 502025004606 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 502025004607 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 502025004608 putative phosphate acyltransferase; Provisional; Region: PRK05331 502025004609 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 502025004610 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025004611 RNA binding surface [nucleotide binding]; other site 502025004612 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025004613 active site 502025004614 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 502025004615 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 502025004616 dimer interface [polypeptide binding]; other site 502025004617 putative functional site; other site 502025004618 putative MPT binding site; other site 502025004619 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 502025004620 N-acetyl-D-glucosamine binding site [chemical binding]; other site 502025004621 catalytic residue [active] 502025004622 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025004623 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025004624 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 502025004625 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 502025004626 FOG: CBS domain [General function prediction only]; Region: COG0517 502025004627 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 502025004628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004629 active site 502025004630 phosphorylation site [posttranslational modification] 502025004631 intermolecular recognition site; other site 502025004632 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 502025004633 cyclase homology domain; Region: CHD; cd07302 502025004634 nucleotidyl binding site; other site 502025004635 metal binding site [ion binding]; metal-binding site 502025004636 dimer interface [polypeptide binding]; other site 502025004637 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 502025004638 Competence protein; Region: Competence; pfam03772 502025004639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 502025004640 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025004641 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025004642 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 502025004643 dinuclear metal binding motif [ion binding]; other site 502025004644 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 502025004645 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 502025004646 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 502025004647 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 502025004648 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 502025004649 ligand binding site [chemical binding]; other site 502025004650 homodimer interface [polypeptide binding]; other site 502025004651 NAD(P) binding site [chemical binding]; other site 502025004652 trimer interface B [polypeptide binding]; other site 502025004653 trimer interface A [polypeptide binding]; other site 502025004654 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025004655 Bacterial SH3 domain; Region: SH3_4; pfam06347 502025004656 Src Homology 3 domain superfamily; Region: SH3; cl17036 502025004657 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004659 active site 502025004660 phosphorylation site [posttranslational modification] 502025004661 intermolecular recognition site; other site 502025004662 dimerization interface [polypeptide binding]; other site 502025004663 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 502025004664 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025004665 metal ion-dependent adhesion site (MIDAS); other site 502025004666 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 502025004667 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 502025004668 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 502025004669 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025004670 FtsX-like permease family; Region: FtsX; pfam02687 502025004671 eight-cysteine-cluster domain; Region: heavy_Cys; TIGR04289 502025004672 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 502025004673 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 502025004674 putative acyl-acceptor binding pocket; other site 502025004675 NADH dehydrogenase subunit E; Validated; Region: PRK07539 502025004676 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 502025004677 putative dimer interface [polypeptide binding]; other site 502025004678 [2Fe-2S] cluster binding site [ion binding]; other site 502025004679 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 502025004680 SLBB domain; Region: SLBB; pfam10531 502025004681 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 502025004682 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 502025004683 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 502025004684 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 502025004685 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 502025004686 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 502025004687 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 502025004688 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 502025004689 NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00150 502025004690 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 502025004691 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 502025004692 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 502025004693 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 502025004694 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 502025004695 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 502025004696 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025004697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025004698 dimer interface [polypeptide binding]; other site 502025004699 phosphorylation site [posttranslational modification] 502025004700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004701 ATP binding site [chemical binding]; other site 502025004702 Mg2+ binding site [ion binding]; other site 502025004703 G-X-G motif; other site 502025004704 Response regulator receiver domain; Region: Response_reg; pfam00072 502025004705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004706 active site 502025004707 phosphorylation site [posttranslational modification] 502025004708 intermolecular recognition site; other site 502025004709 dimerization interface [polypeptide binding]; other site 502025004710 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 502025004711 dimer interface [polypeptide binding]; other site 502025004712 CARDB; Region: CARDB; pfam07705 502025004713 CARDB; Region: CARDB; pfam07705 502025004714 CARDB; Region: CARDB; pfam07705 502025004715 CARDB; Region: CARDB; pfam07705 502025004716 CARDB; Region: CARDB; pfam07705 502025004717 CARDB; Region: CARDB; pfam07705 502025004718 CARDB; Region: CARDB; pfam07705 502025004719 CARDB; Region: CARDB; pfam07705 502025004720 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 502025004721 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004722 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004723 active site 502025004724 ATP binding site [chemical binding]; other site 502025004725 substrate binding site [chemical binding]; other site 502025004726 activation loop (A-loop); other site 502025004727 AAA ATPase domain; Region: AAA_16; pfam13191 502025004728 Predicted ATPase [General function prediction only]; Region: COG3899 502025004729 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025004730 dimerization interface [polypeptide binding]; other site 502025004731 putative DNA binding site [nucleotide binding]; other site 502025004732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025004733 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 502025004734 amidase; Provisional; Region: PRK08137 502025004735 Amidase; Region: Amidase; cl11426 502025004736 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 502025004737 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 502025004738 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004739 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004740 active site 502025004741 ATP binding site [chemical binding]; other site 502025004742 substrate binding site [chemical binding]; other site 502025004743 activation loop (A-loop); other site 502025004744 Predicted ATPase [General function prediction only]; Region: COG3899 502025004745 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025004746 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025004747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004748 ATP binding site [chemical binding]; other site 502025004749 Mg2+ binding site [ion binding]; other site 502025004750 G-X-G motif; other site 502025004751 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 502025004752 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 502025004753 motif 1; other site 502025004754 active site 502025004755 motif 2; other site 502025004756 motif 3; other site 502025004757 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 502025004758 DHHA1 domain; Region: DHHA1; pfam02272 502025004759 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025004760 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025004761 ligand binding site [chemical binding]; other site 502025004762 Protein of unknown function, DUF481; Region: DUF481; pfam04338 502025004763 FecR protein; Region: FecR; pfam04773 502025004764 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 502025004765 MraW methylase family; Region: Methyltransf_5; cl17771 502025004766 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 502025004767 Cell division protein FtsL; Region: FtsL; cl11433 502025004768 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 502025004769 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 502025004770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 502025004771 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 502025004772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 502025004773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 502025004774 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 502025004775 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 502025004776 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025004777 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 502025004778 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 502025004779 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025004780 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 502025004781 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 502025004782 Mg++ binding site [ion binding]; other site 502025004783 putative catalytic motif [active] 502025004784 putative substrate binding site [chemical binding]; other site 502025004785 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 502025004786 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025004787 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 502025004788 cell division protein FtsW; Region: ftsW; TIGR02614 502025004789 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 502025004790 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 502025004791 active site 502025004792 metal binding site [ion binding]; metal-binding site 502025004793 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 502025004794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025004795 RNA binding surface [nucleotide binding]; other site 502025004796 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 502025004797 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004798 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004799 active site 502025004800 ATP binding site [chemical binding]; other site 502025004801 substrate binding site [chemical binding]; other site 502025004802 activation loop (A-loop); other site 502025004803 PEGA domain; Region: PEGA; pfam08308 502025004804 ABC1 family; Region: ABC1; cl17513 502025004805 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 502025004806 Conserved TM helix; Region: TM_helix; pfam05552 502025004807 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025004808 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 502025004809 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 502025004810 inhibitor-cofactor binding pocket; inhibition site 502025004811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025004812 catalytic residue [active] 502025004813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025004814 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025004815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025004816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025004817 dimer interface [polypeptide binding]; other site 502025004818 phosphorylation site [posttranslational modification] 502025004819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025004820 ATP binding site [chemical binding]; other site 502025004821 G-X-G motif; other site 502025004822 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025004823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004824 active site 502025004825 phosphorylation site [posttranslational modification] 502025004826 intermolecular recognition site; other site 502025004827 dimerization interface [polypeptide binding]; other site 502025004828 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025004829 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025004830 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 502025004831 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 502025004832 conserved hypothetical protein; Region: TIGR02231 502025004833 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 502025004834 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 502025004835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004836 active site 502025004837 phosphorylation site [posttranslational modification] 502025004838 intermolecular recognition site; other site 502025004839 dimerization interface [polypeptide binding]; other site 502025004840 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025004841 Methylmalonic aciduria and homocystinuria type C protein and similar proteins; Region: MMACHC-like; cd12959 502025004842 dimer interface [polypeptide binding]; other site 502025004843 cobalamin binding site [chemical binding]; other site 502025004844 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 502025004845 Protein of unknown function DUF72; Region: DUF72; cl00777 502025004846 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004847 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004848 active site 502025004849 ATP binding site [chemical binding]; other site 502025004850 substrate binding site [chemical binding]; other site 502025004851 activation loop (A-loop); other site 502025004852 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025004853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025004854 active site 502025004855 phosphorylation site [posttranslational modification] 502025004856 intermolecular recognition site; other site 502025004857 dimerization interface [polypeptide binding]; other site 502025004858 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025004859 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025004860 metal binding site [ion binding]; metal-binding site 502025004861 active site 502025004862 I-site; other site 502025004863 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 502025004864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025004865 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 502025004866 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004867 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025004868 active site 502025004869 ATP binding site [chemical binding]; other site 502025004870 substrate binding site [chemical binding]; other site 502025004871 activation loop (A-loop); other site 502025004872 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 502025004873 Melibiase; Region: Melibiase; pfam02065 502025004874 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025004875 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025004876 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025004877 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025004878 Predicted permease [General function prediction only]; Region: COG2985 502025004879 Predicted transcriptional regulators [Transcription]; Region: COG1695 502025004880 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 502025004881 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 502025004882 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 502025004883 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025004884 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 502025004885 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 502025004886 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025004887 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025004888 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025004889 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 502025004890 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 502025004891 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025004892 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025004893 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025004894 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025004895 catalytic loop [active] 502025004896 iron binding site [ion binding]; other site 502025004897 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025004898 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 502025004899 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 502025004900 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 502025004901 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 502025004902 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 502025004903 active site 502025004904 substrate-binding site [chemical binding]; other site 502025004905 metal-binding site [ion binding] 502025004906 ATP binding site [chemical binding]; other site 502025004907 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 502025004908 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 502025004909 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 502025004910 putative deacylase active site [active] 502025004911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025004912 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025004913 Walker A motif; other site 502025004914 ATP binding site [chemical binding]; other site 502025004915 Walker B motif; other site 502025004916 arginine finger; other site 502025004917 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 502025004918 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 502025004919 active site 502025004920 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 502025004921 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 502025004922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025004923 Predicted membrane protein [Function unknown]; Region: COG2259 502025004924 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025004925 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025004926 calcium binding site 2 [ion binding]; other site 502025004927 active site 502025004928 catalytic triad [active] 502025004929 calcium binding site 1 [ion binding]; other site 502025004930 hypothetical protein; Provisional; Region: PRK08317 502025004931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025004932 S-adenosylmethionine binding site [chemical binding]; other site 502025004933 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 502025004934 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025004935 acyl-activating enzyme (AAE) consensus motif; other site 502025004936 AMP binding site [chemical binding]; other site 502025004937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025004938 isochorismate synthase DhbC; Validated; Region: PRK06923 502025004939 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 502025004940 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 502025004941 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 502025004942 acyl-activating enzyme (AAE) consensus motif; other site 502025004943 active site 502025004944 AMP binding site [chemical binding]; other site 502025004945 substrate binding site [chemical binding]; other site 502025004946 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 502025004947 Isochorismatase family; Region: Isochorismatase; pfam00857 502025004948 catalytic triad [active] 502025004949 conserved cis-peptide bond; other site 502025004950 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 502025004951 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 502025004952 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 502025004953 FAD binding pocket [chemical binding]; other site 502025004954 FAD binding motif [chemical binding]; other site 502025004955 phosphate binding motif [ion binding]; other site 502025004956 NAD binding pocket [chemical binding]; other site 502025004957 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 502025004958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025004959 NAD(P) binding site [chemical binding]; other site 502025004960 active site 502025004961 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025004962 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 502025004963 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 502025004964 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 502025004965 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 502025004966 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 502025004967 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025004968 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025004969 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025004970 N-terminal plug; other site 502025004971 ligand-binding site [chemical binding]; other site 502025004972 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 502025004973 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 502025004974 Protein of unknown function (DUF962); Region: DUF962; pfam06127 502025004975 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 502025004976 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 502025004977 Walker A/P-loop; other site 502025004978 ATP binding site [chemical binding]; other site 502025004979 Q-loop/lid; other site 502025004980 ABC transporter signature motif; other site 502025004981 Walker B; other site 502025004982 D-loop; other site 502025004983 H-loop/switch region; other site 502025004984 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 502025004985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025004986 dimer interface [polypeptide binding]; other site 502025004987 conserved gate region; other site 502025004988 putative PBP binding loops; other site 502025004989 ABC-ATPase subunit interface; other site 502025004990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 502025004991 NMT1/THI5 like; Region: NMT1; pfam09084 502025004992 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025004993 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025004994 active site 502025004995 ATP binding site [chemical binding]; other site 502025004996 substrate binding site [chemical binding]; other site 502025004997 activation loop (A-loop); other site 502025004998 Predicted ATPase [General function prediction only]; Region: COG3899 502025004999 AAA ATPase domain; Region: AAA_16; pfam13191 502025005000 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005001 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 502025005002 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 502025005003 Walker A/P-loop; other site 502025005004 ATP binding site [chemical binding]; other site 502025005005 Q-loop/lid; other site 502025005006 ABC transporter signature motif; other site 502025005007 Walker B; other site 502025005008 D-loop; other site 502025005009 H-loop/switch region; other site 502025005010 CheB methylesterase; Region: CheB_methylest; pfam01339 502025005011 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005012 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005013 active site 502025005014 ATP binding site [chemical binding]; other site 502025005015 substrate binding site [chemical binding]; other site 502025005016 activation loop (A-loop); other site 502025005017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005018 binding surface 502025005019 TPR motif; other site 502025005020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025005021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005022 TPR motif; other site 502025005023 TPR repeat; Region: TPR_11; pfam13414 502025005024 binding surface 502025005025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005026 binding surface 502025005027 TPR motif; other site 502025005028 TPR repeat; Region: TPR_11; pfam13414 502025005029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025005030 binding surface 502025005031 TPR motif; other site 502025005032 TPR repeat; Region: TPR_11; pfam13414 502025005033 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 502025005034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005035 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025005036 Walker A motif; other site 502025005037 ATP binding site [chemical binding]; other site 502025005038 Walker B motif; other site 502025005039 arginine finger; other site 502025005040 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 502025005041 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 502025005042 putative active site [active] 502025005043 catalytic site [active] 502025005044 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 502025005045 putative active site [active] 502025005046 catalytic site [active] 502025005047 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025005048 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025005049 phosphopeptide binding site; other site 502025005050 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 502025005051 putative dimer interface [polypeptide binding]; other site 502025005052 putative active site [active] 502025005053 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 502025005054 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 502025005055 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 502025005056 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 502025005057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 502025005058 Uncharacterized conserved protein [Function unknown]; Region: COG2308 502025005059 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 502025005060 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 502025005061 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 502025005062 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 502025005063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 502025005064 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 502025005065 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 502025005066 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025005067 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025005068 calcium binding site 2 [ion binding]; other site 502025005069 active site 502025005070 catalytic triad [active] 502025005071 calcium binding site 1 [ion binding]; other site 502025005072 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 502025005073 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 502025005074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025005075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025005076 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025005077 dimerization interface [polypeptide binding]; other site 502025005078 putative effector binding pocket; other site 502025005079 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 502025005080 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025005081 Sulfatase; Region: Sulfatase; pfam00884 502025005082 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 502025005083 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025005084 active site 502025005085 ATP binding site [chemical binding]; other site 502025005086 substrate binding site [chemical binding]; other site 502025005087 activation loop (A-loop); other site 502025005088 hypothetical protein; Provisional; Region: PRK11380 502025005089 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 502025005090 Phosphotransferase enzyme family; Region: APH; pfam01636 502025005091 putative active site [active] 502025005092 putative substrate binding site [chemical binding]; other site 502025005093 ATP binding site [chemical binding]; other site 502025005094 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 502025005095 Domain of unknown function DUF20; Region: UPF0118; pfam01594 502025005096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005097 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025005098 Walker A motif; other site 502025005099 ATP binding site [chemical binding]; other site 502025005100 Walker B motif; other site 502025005101 arginine finger; other site 502025005102 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 502025005103 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 502025005104 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 502025005105 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 502025005106 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 502025005107 putative NAD(P) binding site [chemical binding]; other site 502025005108 active site 502025005109 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 502025005110 NmrA-like family; Region: NmrA; pfam05368 502025005111 NADP binding site [chemical binding]; other site 502025005112 active site 502025005113 regulatory binding site [polypeptide binding]; other site 502025005114 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005116 active site 502025005117 phosphorylation site [posttranslational modification] 502025005118 intermolecular recognition site; other site 502025005119 dimerization interface [polypeptide binding]; other site 502025005120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025005121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005122 dimer interface [polypeptide binding]; other site 502025005123 phosphorylation site [posttranslational modification] 502025005124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005125 ATP binding site [chemical binding]; other site 502025005126 Mg2+ binding site [ion binding]; other site 502025005127 G-X-G motif; other site 502025005128 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005130 active site 502025005131 phosphorylation site [posttranslational modification] 502025005132 intermolecular recognition site; other site 502025005133 dimerization interface [polypeptide binding]; other site 502025005134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005135 dimerization interface [polypeptide binding]; other site 502025005136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005137 dimerization interface [polypeptide binding]; other site 502025005138 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 502025005139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005140 dimerization interface [polypeptide binding]; other site 502025005141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005142 dimerization interface [polypeptide binding]; other site 502025005143 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005144 dimerization interface [polypeptide binding]; other site 502025005145 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 502025005146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005147 dimerization interface [polypeptide binding]; other site 502025005148 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005149 dimerization interface [polypeptide binding]; other site 502025005150 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 502025005151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005152 dimerization interface [polypeptide binding]; other site 502025005153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005154 dimerization interface [polypeptide binding]; other site 502025005155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005156 dimerization interface [polypeptide binding]; other site 502025005157 HAMP domain; Region: HAMP; pfam00672 502025005158 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005159 dimerization interface [polypeptide binding]; other site 502025005160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005161 dimer interface [polypeptide binding]; other site 502025005162 phosphorylation site [posttranslational modification] 502025005163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005164 ATP binding site [chemical binding]; other site 502025005165 Mg2+ binding site [ion binding]; other site 502025005166 G-X-G motif; other site 502025005167 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005169 active site 502025005170 phosphorylation site [posttranslational modification] 502025005171 intermolecular recognition site; other site 502025005172 dimerization interface [polypeptide binding]; other site 502025005173 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005175 active site 502025005176 phosphorylation site [posttranslational modification] 502025005177 intermolecular recognition site; other site 502025005178 dimerization interface [polypeptide binding]; other site 502025005179 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005181 active site 502025005182 phosphorylation site [posttranslational modification] 502025005183 intermolecular recognition site; other site 502025005184 dimerization interface [polypeptide binding]; other site 502025005185 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025005186 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 502025005187 CheB methylesterase; Region: CheB_methylest; pfam01339 502025005188 Cache domain; Region: Cache_1; pfam02743 502025005189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025005190 dimerization interface [polypeptide binding]; other site 502025005191 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025005192 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025005193 ligand binding site [chemical binding]; other site 502025005194 flexible hinge region; other site 502025005195 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 502025005196 putative switch regulator; other site 502025005197 non-specific DNA interactions [nucleotide binding]; other site 502025005198 DNA binding site [nucleotide binding] 502025005199 sequence specific DNA binding site [nucleotide binding]; other site 502025005200 putative cAMP binding site [chemical binding]; other site 502025005201 CAAX protease self-immunity; Region: Abi; pfam02517 502025005202 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 502025005203 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 502025005204 trimer interface [polypeptide binding]; other site 502025005205 putative metal binding site [ion binding]; other site 502025005206 HEAT repeats; Region: HEAT_2; pfam13646 502025005207 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025005208 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025005209 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025005210 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025005211 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025005212 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025005213 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025005214 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 502025005215 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025005216 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025005217 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 502025005218 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 502025005219 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025005220 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025005221 Ycf48-like protein; Provisional; Region: PRK13684 502025005222 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 502025005223 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 502025005224 G1 box; other site 502025005225 putative GEF interaction site [polypeptide binding]; other site 502025005226 GTP/Mg2+ binding site [chemical binding]; other site 502025005227 Switch I region; other site 502025005228 G2 box; other site 502025005229 G3 box; other site 502025005230 Switch II region; other site 502025005231 G4 box; other site 502025005232 G5 box; other site 502025005233 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 502025005234 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 502025005235 LysM domain; Region: LysM; pfam01476 502025005236 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005237 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025005238 active site 502025005239 ATP binding site [chemical binding]; other site 502025005240 substrate binding site [chemical binding]; other site 502025005241 activation loop (A-loop); other site 502025005242 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 502025005243 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 502025005244 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025005245 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 502025005246 active site 502025005247 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 502025005248 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025005249 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025005250 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 502025005251 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025005252 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 502025005253 carboxyltransferase (CT) interaction site; other site 502025005254 biotinylation site [posttranslational modification]; other site 502025005255 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 502025005256 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 502025005257 Domain of unknown function DUF21; Region: DUF21; pfam01595 502025005258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 502025005259 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 502025005260 Domain of unknown function DUF21; Region: DUF21; pfam01595 502025005261 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 502025005262 Transporter associated domain; Region: CorC_HlyC; smart01091 502025005263 CHAD domain; Region: CHAD; pfam05235 502025005264 hypothetical protein; Provisional; Region: PRK05858 502025005265 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 502025005266 PYR/PP interface [polypeptide binding]; other site 502025005267 dimer interface [polypeptide binding]; other site 502025005268 TPP binding site [chemical binding]; other site 502025005269 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 502025005270 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 502025005271 TPP-binding site; other site 502025005272 dimer interface [polypeptide binding]; other site 502025005273 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 502025005274 putative ligand binding site [chemical binding]; other site 502025005275 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 502025005276 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 502025005277 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 502025005278 oligomer interface [polypeptide binding]; other site 502025005279 metal binding site [ion binding]; metal-binding site 502025005280 metal binding site [ion binding]; metal-binding site 502025005281 Cl binding site [ion binding]; other site 502025005282 aspartate ring; other site 502025005283 basic sphincter; other site 502025005284 putative hydrophobic gate; other site 502025005285 periplasmic entrance; other site 502025005286 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 502025005287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025005288 Coenzyme A binding pocket [chemical binding]; other site 502025005289 Predicted amidohydrolase [General function prediction only]; Region: COG0388 502025005290 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 502025005291 putative active site [active] 502025005292 catalytic triad [active] 502025005293 putative dimer interface [polypeptide binding]; other site 502025005294 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 502025005295 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025005296 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 502025005297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025005298 FeS/SAM binding site; other site 502025005299 ATP cone domain; Region: ATP-cone; pfam03477 502025005300 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005301 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025005302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005303 NAD(P) binding site [chemical binding]; other site 502025005304 active site 502025005305 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025005306 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025005307 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025005308 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025005309 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025005310 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025005311 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025005312 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025005313 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025005314 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025005315 Phage Tail Collar Domain; Region: Collar; pfam07484 502025005316 feruloyl-CoA synthase; Reviewed; Region: PRK08180 502025005317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025005318 acyl-activating enzyme (AAE) consensus motif; other site 502025005319 active site 502025005320 AMP binding site [chemical binding]; other site 502025005321 CoA binding site [chemical binding]; other site 502025005322 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025005323 active site 502025005324 Zn binding site [ion binding]; other site 502025005325 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 502025005326 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 502025005327 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025005328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025005329 homodimer interface [polypeptide binding]; other site 502025005330 catalytic residue [active] 502025005331 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025005332 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025005333 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 502025005334 Peptidase family M28; Region: Peptidase_M28; pfam04389 502025005335 active site 502025005336 metal binding site [ion binding]; metal-binding site 502025005337 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025005338 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025005339 Cytochrome P450; Region: p450; cl12078 502025005340 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 502025005341 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 502025005342 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 502025005343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005344 ATP binding site [chemical binding]; other site 502025005345 Mg2+ binding site [ion binding]; other site 502025005346 G-X-G motif; other site 502025005347 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 502025005348 anchoring element; other site 502025005349 dimer interface [polypeptide binding]; other site 502025005350 ATP binding site [chemical binding]; other site 502025005351 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 502025005352 active site 502025005353 putative metal-binding site [ion binding]; other site 502025005354 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 502025005355 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 502025005356 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 502025005357 CAP-like domain; other site 502025005358 active site 502025005359 primary dimer interface [polypeptide binding]; other site 502025005360 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025005361 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 502025005362 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025005363 Bacterial Ig-like domain; Region: Big_5; pfam13205 502025005364 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 502025005365 MG2 domain; Region: A2M_N; pfam01835 502025005366 Alpha-2-macroglobulin family; Region: A2M; pfam00207 502025005367 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 502025005368 surface patch; other site 502025005369 thioester region; other site 502025005370 specificity defining residues; other site 502025005371 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 502025005372 Transglycosylase; Region: Transgly; pfam00912 502025005373 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 502025005374 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 502025005375 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025005376 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 502025005377 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 502025005378 putative active site [active] 502025005379 catalytic triad [active] 502025005380 putative dimer interface [polypeptide binding]; other site 502025005381 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 502025005382 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 502025005383 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 502025005384 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 502025005385 PEGA domain; Region: PEGA; pfam08308 502025005386 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005387 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005388 active site 502025005389 ATP binding site [chemical binding]; other site 502025005390 substrate binding site [chemical binding]; other site 502025005391 activation loop (A-loop); other site 502025005392 HEAT repeats; Region: HEAT_2; pfam13646 502025005393 HEAT repeats; Region: HEAT_2; pfam13646 502025005394 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 502025005395 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 502025005396 DNA binding residues [nucleotide binding] 502025005397 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025005398 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025005399 phosphopeptide binding site; other site 502025005400 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005401 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005402 active site 502025005403 ATP binding site [chemical binding]; other site 502025005404 substrate binding site [chemical binding]; other site 502025005405 activation loop (A-loop); other site 502025005406 Uncharacterized conserved protein [Function unknown]; Region: COG1262 502025005407 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025005408 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 502025005409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025005410 S-adenosylmethionine binding site [chemical binding]; other site 502025005411 Uncharacterized conserved protein [Function unknown]; Region: COG3349 502025005412 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 502025005413 [2Fe-2S] cluster binding site [ion binding]; other site 502025005414 iron-sulfur cluster [ion binding]; other site 502025005415 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025005416 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 502025005417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 502025005418 Predicted kinase [General function prediction only]; Region: COG0645 502025005419 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005420 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 502025005421 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025005422 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025005423 TIGR02594 family protein; Region: TIGR02594 502025005424 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025005425 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005426 active site 502025005427 ATP binding site [chemical binding]; other site 502025005428 substrate binding site [chemical binding]; other site 502025005429 activation loop (A-loop); other site 502025005430 TPR repeat; Region: TPR_11; pfam13414 502025005431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025005432 binding surface 502025005433 TPR motif; other site 502025005434 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 502025005435 active site clefts [active] 502025005436 zinc binding site [ion binding]; other site 502025005437 dimer interface [polypeptide binding]; other site 502025005438 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005439 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005440 active site 502025005441 ATP binding site [chemical binding]; other site 502025005442 substrate binding site [chemical binding]; other site 502025005443 activation loop (A-loop); other site 502025005444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025005445 PAS domain; Region: PAS_9; pfam13426 502025005446 putative active site [active] 502025005447 heme pocket [chemical binding]; other site 502025005448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005449 dimer interface [polypeptide binding]; other site 502025005450 phosphorylation site [posttranslational modification] 502025005451 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025005452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005453 active site 502025005454 phosphorylation site [posttranslational modification] 502025005455 intermolecular recognition site; other site 502025005456 dimerization interface [polypeptide binding]; other site 502025005457 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005459 active site 502025005460 phosphorylation site [posttranslational modification] 502025005461 intermolecular recognition site; other site 502025005462 dimerization interface [polypeptide binding]; other site 502025005463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025005465 dimer interface [polypeptide binding]; other site 502025005466 phosphorylation site [posttranslational modification] 502025005467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005468 ATP binding site [chemical binding]; other site 502025005469 Mg2+ binding site [ion binding]; other site 502025005470 G-X-G motif; other site 502025005471 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 502025005472 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025005473 Protein kinase domain; Region: Pkinase; pfam00069 502025005474 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005475 active site 502025005476 ATP binding site [chemical binding]; other site 502025005477 substrate binding site [chemical binding]; other site 502025005478 activation loop (A-loop); other site 502025005479 AAA ATPase domain; Region: AAA_16; pfam13191 502025005480 Predicted ATPase [General function prediction only]; Region: COG3899 502025005481 Walker A motif; other site 502025005482 ATP binding site [chemical binding]; other site 502025005483 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025005484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025005485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005486 dimer interface [polypeptide binding]; other site 502025005487 phosphorylation site [posttranslational modification] 502025005488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005489 ATP binding site [chemical binding]; other site 502025005490 G-X-G motif; other site 502025005491 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025005492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005493 active site 502025005494 phosphorylation site [posttranslational modification] 502025005495 intermolecular recognition site; other site 502025005496 dimerization interface [polypeptide binding]; other site 502025005497 phenylhydantoinase; Validated; Region: PRK08323 502025005498 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 502025005499 tetramer interface [polypeptide binding]; other site 502025005500 active site 502025005501 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025005502 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025005503 structural tetrad; other site 502025005504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005505 Walker A motif; other site 502025005506 ATP binding site [chemical binding]; other site 502025005507 Walker B motif; other site 502025005508 FAD binding domain; Region: FAD_binding_4; pfam01565 502025005509 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 502025005510 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 502025005511 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 502025005512 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025005513 active site residue [active] 502025005514 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 502025005515 ATP binding site [chemical binding]; other site 502025005516 substrate interface [chemical binding]; other site 502025005517 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005518 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005519 active site 502025005520 ATP binding site [chemical binding]; other site 502025005521 substrate binding site [chemical binding]; other site 502025005522 activation loop (A-loop); other site 502025005523 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 502025005524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025005525 Zn2+ binding site [ion binding]; other site 502025005526 Mg2+ binding site [ion binding]; other site 502025005527 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 502025005528 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025005529 DNA binding residues [nucleotide binding] 502025005530 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025005531 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 502025005532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025005533 catalytic residue [active] 502025005534 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 502025005535 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025005536 active site 502025005537 Stringent starvation protein B; Region: SspB; cl01120 502025005538 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 502025005539 active site 502025005540 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 502025005541 active site 502025005542 catalytic residues [active] 502025005543 metal binding site [ion binding]; metal-binding site 502025005544 Domain of unknown function DUF59; Region: DUF59; pfam01883 502025005545 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 502025005546 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 502025005547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025005548 active site 502025005549 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 502025005550 Rubrerythrin [Energy production and conversion]; Region: COG1592 502025005551 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 502025005552 binuclear metal center [ion binding]; other site 502025005553 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 502025005554 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 502025005555 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 502025005556 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 502025005557 Acyltransferase family; Region: Acyl_transf_3; pfam01757 502025005558 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 502025005559 active site 502025005560 catalytic triad [active] 502025005561 oxyanion hole [active] 502025005562 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 502025005563 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 502025005564 active site 502025005565 putative substrate binding pocket [chemical binding]; other site 502025005566 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025005567 bile acid transporter; Region: bass; TIGR00841 502025005568 Sodium Bile acid symporter family; Region: SBF; cl17470 502025005569 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 502025005570 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 502025005571 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025005572 catalytic residue [active] 502025005573 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 502025005574 lycopene cyclase; Region: lycopene_cycl; TIGR01789 502025005575 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 502025005576 substrate binding pocket [chemical binding]; other site 502025005577 substrate-Mg2+ binding site; other site 502025005578 aspartate-rich region 1; other site 502025005579 aspartate-rich region 2; other site 502025005580 phytoene desaturase; Region: crtI_fam; TIGR02734 502025005581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 502025005582 hydroxyglutarate oxidase; Provisional; Region: PRK11728 502025005583 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 502025005584 active site lid residues [active] 502025005585 substrate binding pocket [chemical binding]; other site 502025005586 catalytic residues [active] 502025005587 substrate-Mg2+ binding site; other site 502025005588 aspartate-rich region 1; other site 502025005589 aspartate-rich region 2; other site 502025005590 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 502025005591 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 502025005592 DNA binding residues [nucleotide binding] 502025005593 B12 binding domain; Region: B12-binding_2; pfam02607 502025005594 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 502025005595 B12 binding site [chemical binding]; other site 502025005596 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 502025005597 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025005598 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005599 active site 502025005600 ATP binding site [chemical binding]; other site 502025005601 substrate binding site [chemical binding]; other site 502025005602 activation loop (A-loop); other site 502025005603 AAA ATPase domain; Region: AAA_16; pfam13191 502025005604 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 502025005605 active site 502025005606 NTP binding site [chemical binding]; other site 502025005607 metal binding triad [ion binding]; metal-binding site 502025005608 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 502025005609 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005610 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005611 active site 502025005612 ATP binding site [chemical binding]; other site 502025005613 substrate binding site [chemical binding]; other site 502025005614 activation loop (A-loop); other site 502025005615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025005616 PAS fold; Region: PAS_3; pfam08447 502025005617 putative active site [active] 502025005618 heme pocket [chemical binding]; other site 502025005619 PAS domain S-box; Region: sensory_box; TIGR00229 502025005620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025005621 putative active site [active] 502025005622 heme pocket [chemical binding]; other site 502025005623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005624 dimer interface [polypeptide binding]; other site 502025005625 phosphorylation site [posttranslational modification] 502025005626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005627 ATP binding site [chemical binding]; other site 502025005628 Mg2+ binding site [ion binding]; other site 502025005629 G-X-G motif; other site 502025005630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005631 active site 502025005632 phosphorylation site [posttranslational modification] 502025005633 intermolecular recognition site; other site 502025005634 dimerization interface [polypeptide binding]; other site 502025005635 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 502025005636 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005637 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005638 active site 502025005639 ATP binding site [chemical binding]; other site 502025005640 substrate binding site [chemical binding]; other site 502025005641 activation loop (A-loop); other site 502025005642 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025005643 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025005644 putative active site [active] 502025005645 putative metal binding site [ion binding]; other site 502025005646 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025005647 NACHT domain; Region: NACHT; pfam05729 502025005648 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 502025005649 TIR domain; Region: TIR_2; pfam13676 502025005650 Uncharacterized conserved protein [Function unknown]; Region: COG1262 502025005651 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025005652 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 502025005653 putative lipid kinase; Reviewed; Region: PRK13057 502025005654 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 502025005655 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 502025005656 putative RNA binding site [nucleotide binding]; other site 502025005657 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 502025005658 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025005659 GAF domain; Region: GAF; pfam01590 502025005660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025005661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005662 dimer interface [polypeptide binding]; other site 502025005663 phosphorylation site [posttranslational modification] 502025005664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005665 ATP binding site [chemical binding]; other site 502025005666 Mg2+ binding site [ion binding]; other site 502025005667 G-X-G motif; other site 502025005668 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025005669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005670 active site 502025005671 phosphorylation site [posttranslational modification] 502025005672 intermolecular recognition site; other site 502025005673 dimerization interface [polypeptide binding]; other site 502025005674 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025005675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025005676 NAD(P) binding site [chemical binding]; other site 502025005677 active site 502025005678 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025005679 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005680 active site 502025005681 ATP binding site [chemical binding]; other site 502025005682 substrate binding site [chemical binding]; other site 502025005683 activation loop (A-loop); other site 502025005684 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025005685 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 502025005686 Walker A/P-loop; other site 502025005687 ATP binding site [chemical binding]; other site 502025005688 Q-loop/lid; other site 502025005689 ABC transporter signature motif; other site 502025005690 Walker B; other site 502025005691 D-loop; other site 502025005692 H-loop/switch region; other site 502025005693 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025005694 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 502025005695 Walker A/P-loop; other site 502025005696 ATP binding site [chemical binding]; other site 502025005697 Q-loop/lid; other site 502025005698 ABC transporter signature motif; other site 502025005699 Walker B; other site 502025005700 D-loop; other site 502025005701 H-loop/switch region; other site 502025005702 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 502025005703 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 502025005704 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 502025005705 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005706 enolase; Provisional; Region: eno; PRK00077 502025005707 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 502025005708 dimer interface [polypeptide binding]; other site 502025005709 metal binding site [ion binding]; metal-binding site 502025005710 substrate binding pocket [chemical binding]; other site 502025005711 SnoaL-like domain; Region: SnoaL_3; pfam13474 502025005712 homoserine dehydrogenase; Provisional; Region: PRK06349 502025005713 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 502025005714 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 502025005715 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 502025005716 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 502025005717 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 502025005718 putative active site [active] 502025005719 Right handed beta helix region; Region: Beta_helix; pfam13229 502025005720 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 502025005721 catalytic triad [active] 502025005722 conserved cis-peptide bond; other site 502025005723 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 502025005724 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025005725 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 502025005726 NAD(P) binding site [chemical binding]; other site 502025005727 16S rRNA methyltransferase B; Provisional; Region: PRK14901 502025005728 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 502025005729 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 502025005730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005731 Walker A motif; other site 502025005732 ATP binding site [chemical binding]; other site 502025005733 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 502025005734 Walker B motif; other site 502025005735 arginine finger; other site 502025005736 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 502025005737 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 502025005738 active site 502025005739 HslU subunit interaction site [polypeptide binding]; other site 502025005740 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 502025005741 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025005742 active site 502025005743 DNA binding site [nucleotide binding] 502025005744 Int/Topo IB signature motif; other site 502025005745 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 502025005746 putative FMN binding site [chemical binding]; other site 502025005747 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005749 active site 502025005750 phosphorylation site [posttranslational modification] 502025005751 intermolecular recognition site; other site 502025005752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025005753 dimerization interface [polypeptide binding]; other site 502025005754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005755 dimer interface [polypeptide binding]; other site 502025005756 phosphorylation site [posttranslational modification] 502025005757 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 502025005758 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 502025005759 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 502025005760 Probable Catalytic site; other site 502025005761 metal-binding site 502025005762 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025005763 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025005764 calcium binding site 2 [ion binding]; other site 502025005765 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 502025005766 active site 502025005767 catalytic triad [active] 502025005768 calcium binding site 1 [ion binding]; other site 502025005769 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025005770 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025005771 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025005772 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 502025005773 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025005774 calcium binding site 2 [ion binding]; other site 502025005775 active site 502025005776 catalytic triad [active] 502025005777 calcium binding site 1 [ion binding]; other site 502025005778 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025005779 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025005780 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025005781 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 502025005782 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025005783 calcium binding site 2 [ion binding]; other site 502025005784 active site 502025005785 catalytic triad [active] 502025005786 calcium binding site 1 [ion binding]; other site 502025005787 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025005788 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 502025005789 Zn binding site [ion binding]; other site 502025005790 tellurite resistance protein terB; Region: terB; cd07176 502025005791 putative metal binding site [ion binding]; other site 502025005792 OPT oligopeptide transporter protein; Region: OPT; cl14607 502025005793 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 502025005794 active site 502025005795 ADP/pyrophosphate binding site [chemical binding]; other site 502025005796 dimerization interface [polypeptide binding]; other site 502025005797 allosteric effector site; other site 502025005798 fructose-1,6-bisphosphate binding site; other site 502025005799 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025005800 Protein kinase domain; Region: Pkinase; pfam00069 502025005801 active site 502025005802 ATP binding site [chemical binding]; other site 502025005803 substrate binding site [chemical binding]; other site 502025005804 activation loop (A-loop); other site 502025005805 Predicted ATPase [General function prediction only]; Region: COG3899 502025005806 AAA ATPase domain; Region: AAA_16; pfam13191 502025005807 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025005808 GAF domain; Region: GAF; pfam01590 502025005809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025005810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005811 ATP binding site [chemical binding]; other site 502025005812 Mg2+ binding site [ion binding]; other site 502025005813 G-X-G motif; other site 502025005814 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025005815 active site 502025005816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025005817 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 502025005818 dimerization interface [polypeptide binding]; other site 502025005819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025005820 dimer interface [polypeptide binding]; other site 502025005821 phosphorylation site [posttranslational modification] 502025005822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025005823 ATP binding site [chemical binding]; other site 502025005824 Mg2+ binding site [ion binding]; other site 502025005825 G-X-G motif; other site 502025005826 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025005827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005828 active site 502025005829 phosphorylation site [posttranslational modification] 502025005830 intermolecular recognition site; other site 502025005831 dimerization interface [polypeptide binding]; other site 502025005832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005833 Walker A motif; other site 502025005834 ATP binding site [chemical binding]; other site 502025005835 Walker B motif; other site 502025005836 arginine finger; other site 502025005837 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025005838 Response regulator receiver domain; Region: Response_reg; pfam00072 502025005839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025005840 active site 502025005841 phosphorylation site [posttranslational modification] 502025005842 intermolecular recognition site; other site 502025005843 dimerization interface [polypeptide binding]; other site 502025005844 probable polyamine oxidase; Region: PLN02268 502025005845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 502025005846 Sulfatase; Region: Sulfatase; pfam00884 502025005847 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025005848 Uncharacterized conserved protein [Function unknown]; Region: COG3379 502025005849 Uncharacterized conserved protein [Function unknown]; Region: COG3379 502025005850 Uncharacterized conserved protein [Function unknown]; Region: COG3379 502025005851 Uncharacterized conserved protein [Function unknown]; Region: COG3379 502025005852 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 502025005853 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 502025005854 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005855 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025005856 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 502025005857 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 502025005858 TM-ABC transporter signature motif; other site 502025005859 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603 502025005860 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 502025005861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025005862 Walker A/P-loop; other site 502025005863 ATP binding site [chemical binding]; other site 502025005864 Q-loop/lid; other site 502025005865 ABC transporter signature motif; other site 502025005866 Walker B; other site 502025005867 D-loop; other site 502025005868 H-loop/switch region; other site 502025005869 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 502025005870 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 502025005871 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 502025005872 putative ligand binding site [chemical binding]; other site 502025005873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025005874 S-adenosylmethionine binding site [chemical binding]; other site 502025005875 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 502025005876 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 502025005877 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 502025005878 homodimer interface [polypeptide binding]; other site 502025005879 metal binding site [ion binding]; metal-binding site 502025005880 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 502025005881 homodimer interface [polypeptide binding]; other site 502025005882 active site 502025005883 putative chemical substrate binding site [chemical binding]; other site 502025005884 metal binding site [ion binding]; metal-binding site 502025005885 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 502025005886 PhoH-like protein; Region: PhoH; pfam02562 502025005887 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025005888 GAF domain; Region: GAF_2; pfam13185 502025005889 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025005890 Zn2+ binding site [ion binding]; other site 502025005891 Mg2+ binding site [ion binding]; other site 502025005892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025005893 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 502025005894 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 502025005895 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 502025005896 potential frameshift: common BLAST hit: gi|197121788|ref|YP_002133739.1| FAD dependent oxidoreductase 502025005897 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 502025005898 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 502025005899 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 502025005900 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 502025005901 PQQ-like domain; Region: PQQ_2; pfam13360 502025005902 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025005903 putative catalytic site [active] 502025005904 putative metal binding site [ion binding]; other site 502025005905 putative phosphate binding site [ion binding]; other site 502025005906 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025005907 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025005908 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025005909 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025005910 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025005911 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025005912 Uncharacterized conserved protein [Function unknown]; Region: COG3268 502025005913 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 502025005914 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025005915 phosphopeptide binding site; other site 502025005916 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 502025005917 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025005918 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 502025005919 interface (dimer of trimers) [polypeptide binding]; other site 502025005920 Substrate-binding/catalytic site; other site 502025005921 Zn-binding sites [ion binding]; other site 502025005922 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 502025005923 Y-family of DNA polymerases; Region: PolY; cl12025 502025005924 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 502025005925 generic binding surface II; other site 502025005926 ssDNA binding site; other site 502025005927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025005928 putative Mg++ binding site [ion binding]; other site 502025005929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025005930 nucleotide binding region [chemical binding]; other site 502025005931 ATP-binding site [chemical binding]; other site 502025005932 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 502025005933 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 502025005934 NHL repeat; Region: NHL; pfam01436 502025005935 NHL repeat; Region: NHL; pfam01436 502025005936 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025005937 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025005938 active site 502025005939 catalytic tetrad [active] 502025005940 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 502025005941 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 502025005942 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025005943 metal ion-dependent adhesion site (MIDAS); other site 502025005944 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025005945 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 502025005946 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 502025005947 active site 502025005948 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 502025005949 classical (c) SDRs; Region: SDR_c; cd05233 502025005950 NAD(P) binding site [chemical binding]; other site 502025005951 active site 502025005952 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 502025005953 Beta-lactamase; Region: Beta-lactamase; pfam00144 502025005954 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 502025005955 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025005956 substrate binding site [chemical binding]; other site 502025005957 oxyanion hole (OAH) forming residues; other site 502025005958 trimer interface [polypeptide binding]; other site 502025005959 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025005960 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025005961 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025005962 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025005963 active site 502025005964 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 502025005965 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 502025005966 catalytic residues [active] 502025005967 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 502025005968 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 502025005969 active site 502025005970 NAD binding site [chemical binding]; other site 502025005971 metal binding site [ion binding]; metal-binding site 502025005972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025005973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025005974 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 502025005975 substrate binding pocket [chemical binding]; other site 502025005976 dimerization interface [polypeptide binding]; other site 502025005977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025005978 S-adenosylmethionine binding site [chemical binding]; other site 502025005979 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 502025005980 high affinity sulphate transporter 1; Region: sulP; TIGR00815 502025005981 Sulfate transporter family; Region: Sulfate_transp; pfam00916 502025005982 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 502025005983 Sulphur transport; Region: Sulf_transp; pfam04143 502025005984 Predicted transporter component [General function prediction only]; Region: COG2391 502025005985 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 502025005986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 502025005987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025005988 Uncharacterized conserved protein [Function unknown]; Region: COG2427 502025005989 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 502025005990 active site 502025005991 NTP binding site [chemical binding]; other site 502025005992 metal binding triad [ion binding]; metal-binding site 502025005993 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 502025005994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025005995 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025005996 Walker A motif; other site 502025005997 ATP binding site [chemical binding]; other site 502025005998 Walker B motif; other site 502025005999 arginine finger; other site 502025006000 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025006001 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 502025006002 putative FMN binding site [chemical binding]; other site 502025006003 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025006004 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 502025006005 putative C-terminal domain interface [polypeptide binding]; other site 502025006006 putative GSH binding site (G-site) [chemical binding]; other site 502025006007 putative dimer interface [polypeptide binding]; other site 502025006008 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025006009 N-terminal domain interface [polypeptide binding]; other site 502025006010 dimer interface [polypeptide binding]; other site 502025006011 substrate binding pocket (H-site) [chemical binding]; other site 502025006012 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025006013 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025006014 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 502025006015 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025006016 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006017 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006018 active site 502025006019 ATP binding site [chemical binding]; other site 502025006020 substrate binding site [chemical binding]; other site 502025006021 activation loop (A-loop); other site 502025006022 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 502025006023 metal binding site [ion binding]; metal-binding site 502025006024 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006025 active site 502025006026 ATP binding site [chemical binding]; other site 502025006027 substrate binding site [chemical binding]; other site 502025006028 activation loop (A-loop); other site 502025006029 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006030 Tetratricopeptide repeat; Region: TPR_10; pfam13374 502025006031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006032 Tetratricopeptide repeat; Region: TPR_10; pfam13374 502025006033 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006034 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006035 TPR motif; other site 502025006036 binding surface 502025006037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006038 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006039 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006041 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 502025006042 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025006043 acyl-activating enzyme (AAE) consensus motif; other site 502025006044 active site 502025006045 AMP binding site [chemical binding]; other site 502025006046 CoA binding site [chemical binding]; other site 502025006047 TPR repeat; Region: TPR_11; pfam13414 502025006048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006049 TPR motif; other site 502025006050 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 502025006051 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 502025006052 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 502025006053 active site 502025006054 dimer interface [polypeptide binding]; other site 502025006055 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 502025006056 dimer interface [polypeptide binding]; other site 502025006057 active site 502025006058 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025006059 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025006060 phosphopeptide binding site; other site 502025006061 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025006062 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025006063 metal binding site [ion binding]; metal-binding site 502025006064 active site 502025006065 I-site; other site 502025006066 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025006067 Protein of unknown function DUF58; Region: DUF58; pfam01882 502025006068 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025006069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006070 Walker A motif; other site 502025006071 ATP binding site [chemical binding]; other site 502025006072 Walker B motif; other site 502025006073 arginine finger; other site 502025006074 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 502025006075 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 502025006076 cytidylate kinase; Provisional; Region: cmk; PRK00023 502025006077 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 502025006078 CMP-binding site; other site 502025006079 The sites determining sugar specificity; other site 502025006080 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 502025006081 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 502025006082 RNA binding site [nucleotide binding]; other site 502025006083 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 502025006084 RNA binding site [nucleotide binding]; other site 502025006085 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 502025006086 RNA binding site [nucleotide binding]; other site 502025006087 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025006088 RNA binding site [nucleotide binding]; other site 502025006089 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 502025006090 RNA binding site [nucleotide binding]; other site 502025006091 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 502025006092 RNA binding site [nucleotide binding]; other site 502025006093 tetratricopeptide repeat protein; Provisional; Region: PRK11788 502025006094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006095 binding surface 502025006096 TPR motif; other site 502025006097 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025006098 Domain of unknown function DUF20; Region: UPF0118; pfam01594 502025006099 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 502025006100 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006101 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006102 active site 502025006103 ATP binding site [chemical binding]; other site 502025006104 substrate binding site [chemical binding]; other site 502025006105 activation loop (A-loop); other site 502025006106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025006107 binding surface 502025006108 TPR motif; other site 502025006109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 502025006110 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025006111 dimerization interface [polypeptide binding]; other site 502025006112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006113 dimer interface [polypeptide binding]; other site 502025006114 phosphorylation site [posttranslational modification] 502025006115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006116 ATP binding site [chemical binding]; other site 502025006117 Mg2+ binding site [ion binding]; other site 502025006118 G-X-G motif; other site 502025006119 homoserine kinase; Provisional; Region: PRK01212 502025006120 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 502025006121 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 502025006122 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 502025006123 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 502025006124 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 502025006125 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 502025006126 Protein export membrane protein; Region: SecD_SecF; cl14618 502025006127 Protein export membrane protein; Region: SecD_SecF; pfam02355 502025006128 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 502025006129 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 502025006130 DHH family; Region: DHH; pfam01368 502025006131 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 502025006132 Isochorismatase family; Region: Isochorismatase; pfam00857 502025006133 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 502025006134 catalytic triad [active] 502025006135 conserved cis-peptide bond; other site 502025006136 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 502025006137 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 502025006138 Bacterial SH3 domain; Region: SH3_3; cl17532 502025006139 AAA ATPase domain; Region: AAA_16; pfam13191 502025006140 Predicted ATPase [General function prediction only]; Region: COG3899 502025006141 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006142 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006144 TPR motif; other site 502025006145 binding surface 502025006146 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006147 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 502025006148 active site 502025006149 NTP binding site [chemical binding]; other site 502025006150 metal binding triad [ion binding]; metal-binding site 502025006151 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 502025006152 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025006153 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 502025006154 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025006155 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 502025006156 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 502025006157 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 502025006158 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 502025006159 heme-binding residues [chemical binding]; other site 502025006160 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025006161 molybdopterin cofactor binding site; other site 502025006162 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 502025006163 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 502025006164 4Fe-4S binding domain; Region: Fer4_2; pfam12797 502025006165 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 502025006166 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 502025006167 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 502025006168 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 502025006169 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 502025006170 Cu(I) binding site [ion binding]; other site 502025006171 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 502025006172 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 502025006173 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 502025006174 Cytochrome c; Region: Cytochrom_C; pfam00034 502025006175 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 502025006176 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 502025006177 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 502025006178 Subunit I/III interface [polypeptide binding]; other site 502025006179 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 502025006180 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 502025006181 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 502025006182 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 502025006183 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 502025006184 dimer interface [polypeptide binding]; other site 502025006185 substrate binding site [chemical binding]; other site 502025006186 ATP binding site [chemical binding]; other site 502025006187 Pantoate-beta-alanine ligase; Region: PanC; cd00560 502025006188 pantoate--beta-alanine ligase; Region: panC; TIGR00018 502025006189 active site 502025006190 ATP-binding site [chemical binding]; other site 502025006191 pantoate-binding site; other site 502025006192 HXXH motif; other site 502025006193 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 502025006194 oligomerization interface [polypeptide binding]; other site 502025006195 active site 502025006196 metal binding site [ion binding]; metal-binding site 502025006197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006198 TPR motif; other site 502025006199 binding surface 502025006200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025006201 binding surface 502025006202 TPR motif; other site 502025006203 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 502025006204 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025006205 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025006206 ligand binding site [chemical binding]; other site 502025006207 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 502025006208 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 502025006209 active site 502025006210 Riboflavin kinase; Region: Flavokinase; smart00904 502025006211 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 502025006212 dihydrodipicolinate synthase; Region: dapA; TIGR00674 502025006213 dimer interface [polypeptide binding]; other site 502025006214 active site 502025006215 catalytic residue [active] 502025006216 dihydrodipicolinate reductase; Provisional; Region: PRK00048 502025006217 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 502025006218 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 502025006219 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 502025006220 Putative zinc ribbon domain; Region: DUF164; pfam02591 502025006221 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 502025006222 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 502025006223 LexA repressor; Validated; Region: PRK00215 502025006224 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 502025006225 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 502025006226 Catalytic site [active] 502025006227 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025006228 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 502025006229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025006230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006231 dimer interface [polypeptide binding]; other site 502025006232 phosphorylation site [posttranslational modification] 502025006233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006234 ATP binding site [chemical binding]; other site 502025006235 Mg2+ binding site [ion binding]; other site 502025006236 G-X-G motif; other site 502025006237 circadian clock protein KaiC; Reviewed; Region: PRK09302 502025006238 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025006239 Walker A motif; other site 502025006240 ATP binding site [chemical binding]; other site 502025006241 Walker B motif; other site 502025006242 recA bacterial DNA recombination protein; Region: RecA; cl17211 502025006243 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025006244 Walker A motif; other site 502025006245 ATP binding site [chemical binding]; other site 502025006246 Walker B motif; other site 502025006247 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 502025006248 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 502025006249 Predicted flavoprotein [General function prediction only]; Region: COG0431 502025006250 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 502025006251 putative active site [active] 502025006252 putative CoA binding site [chemical binding]; other site 502025006253 nudix motif; other site 502025006254 metal binding site [ion binding]; metal-binding site 502025006255 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025006256 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 502025006257 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 502025006258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025006259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025006260 Predicted acyl esterases [General function prediction only]; Region: COG2936 502025006261 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 502025006262 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 502025006263 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 502025006264 minor groove reading motif; other site 502025006265 helix-hairpin-helix signature motif; other site 502025006266 substrate binding pocket [chemical binding]; other site 502025006267 active site 502025006268 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 502025006269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025006270 RNA binding surface [nucleotide binding]; other site 502025006271 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025006272 active site 502025006273 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 502025006274 NAD-dependent deacetylase; Provisional; Region: PRK00481 502025006275 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 502025006276 putative active site [active] 502025006277 putative cosubstrate binding site; other site 502025006278 putative substrate binding site [chemical binding]; other site 502025006279 catalytic site [active] 502025006280 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 502025006281 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 502025006282 putative active site [active] 502025006283 metal binding site [ion binding]; metal-binding site 502025006284 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 502025006285 ATP-NAD kinase; Region: NAD_kinase; pfam01513 502025006286 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 502025006287 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 502025006288 Walker A/P-loop; other site 502025006289 ATP binding site [chemical binding]; other site 502025006290 Q-loop/lid; other site 502025006291 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 502025006292 ABC transporter signature motif; other site 502025006293 Walker B; other site 502025006294 D-loop; other site 502025006295 H-loop/switch region; other site 502025006296 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 502025006297 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 502025006298 Protein of unknown function (DUF3103); Region: DUF3103; pfam11301 502025006299 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 502025006300 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 502025006301 active site 502025006302 Ca binding site [ion binding]; other site 502025006303 catalytic site [active] 502025006304 Aamy_C domain; Region: Aamy_C; smart00632 502025006305 Glucan 1,4-alpha-maltotetraohydrolase (alpha-MTH), C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Alpha-MTH, also known as maltotetraose-forming exo-amylase or G4-amylase, is an exo-amylase found in bacteria that degrades starch from...; Region: CBM20_alpha_MTH; cd05810 502025006306 starch-binding site 2 [chemical binding]; other site 502025006307 starch-binding site 1 [chemical binding]; other site 502025006308 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 502025006309 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 502025006310 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 502025006311 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 502025006312 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025006313 active site 502025006314 metal binding site [ion binding]; metal-binding site 502025006315 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025006316 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 502025006317 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 502025006318 KH domain; Region: KH_4; pfam13083 502025006319 G-X-X-G motif; other site 502025006320 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 502025006321 RimM N-terminal domain; Region: RimM; pfam01782 502025006322 PRC-barrel domain; Region: PRC; pfam05239 502025006323 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 502025006324 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853 502025006325 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 502025006326 hypothetical protein; Reviewed; Region: PRK12497 502025006327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006328 binding surface 502025006329 TPR motif; other site 502025006330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006331 TPR motif; other site 502025006332 binding surface 502025006333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006334 binding surface 502025006335 TPR motif; other site 502025006336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006337 binding surface 502025006338 TPR repeat; Region: TPR_11; pfam13414 502025006339 TPR motif; other site 502025006340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025006341 binding surface 502025006342 TPR motif; other site 502025006343 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 502025006344 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 502025006345 Cl- selectivity filter; other site 502025006346 Cl- binding residues [ion binding]; other site 502025006347 pore gating glutamate residue; other site 502025006348 dimer interface [polypeptide binding]; other site 502025006349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 502025006350 FOG: CBS domain [General function prediction only]; Region: COG0517 502025006351 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 502025006352 MOFRL family; Region: MOFRL; pfam05161 502025006353 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 502025006354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025006355 S-adenosylmethionine binding site [chemical binding]; other site 502025006356 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 502025006357 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 502025006358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025006359 FeS/SAM binding site; other site 502025006360 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 502025006361 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 502025006362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025006363 catalytic residue [active] 502025006364 Protein kinase domain; Region: Pkinase; pfam00069 502025006365 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006366 active site 502025006367 ATP binding site [chemical binding]; other site 502025006368 substrate binding site [chemical binding]; other site 502025006369 activation loop (A-loop); other site 502025006370 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006371 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006372 active site 502025006373 ATP binding site [chemical binding]; other site 502025006374 substrate binding site [chemical binding]; other site 502025006375 activation loop (A-loop); other site 502025006376 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006378 TPR motif; other site 502025006379 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006380 binding surface 502025006381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025006382 TPR repeat; Region: TPR_11; pfam13414 502025006383 binding surface 502025006384 Nudix hydrolase homolog; Region: PLN02791 502025006385 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 502025006386 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025006387 Sulfatase; Region: Sulfatase; pfam00884 502025006388 PA14 domain; Region: PA14; cl08459 502025006389 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025006390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006391 active site 502025006392 phosphorylation site [posttranslational modification] 502025006393 intermolecular recognition site; other site 502025006394 dimerization interface [polypeptide binding]; other site 502025006395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006396 Walker A motif; other site 502025006397 ATP binding site [chemical binding]; other site 502025006398 Walker B motif; other site 502025006399 arginine finger; other site 502025006400 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025006401 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025006402 Cytochrome P450; Region: p450; cl12078 502025006403 Predicted methyltransferases [General function prediction only]; Region: COG0313 502025006404 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 502025006405 putative SAM binding site [chemical binding]; other site 502025006406 putative homodimer interface [polypeptide binding]; other site 502025006407 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 502025006408 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 502025006409 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025006410 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 502025006411 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025006412 DNA binding residues [nucleotide binding] 502025006413 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 502025006414 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 502025006415 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 502025006416 protein binding site [polypeptide binding]; other site 502025006417 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 502025006418 Catalytic dyad [active] 502025006419 Bacterial SH3 domain; Region: SH3_3; pfam08239 502025006420 Predicted amidohydrolase [General function prediction only]; Region: COG0388 502025006421 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 502025006422 putative active site [active] 502025006423 catalytic triad [active] 502025006424 putative dimer interface [polypeptide binding]; other site 502025006425 aminotransferase; Validated; Region: PRK07777 502025006426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025006427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025006428 homodimer interface [polypeptide binding]; other site 502025006429 catalytic residue [active] 502025006430 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 502025006431 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006432 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006433 active site 502025006434 ATP binding site [chemical binding]; other site 502025006435 substrate binding site [chemical binding]; other site 502025006436 activation loop (A-loop); other site 502025006437 PEGA domain; Region: PEGA; pfam08308 502025006438 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006439 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006440 active site 502025006441 ATP binding site [chemical binding]; other site 502025006442 substrate binding site [chemical binding]; other site 502025006443 activation loop (A-loop); other site 502025006444 TPR repeat; Region: TPR_11; pfam13414 502025006445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006446 binding surface 502025006447 TPR motif; other site 502025006448 PEGA domain; Region: PEGA; pfam08308 502025006449 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025006450 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025006451 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025006452 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025006453 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025006454 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025006455 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025006456 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025006457 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 502025006458 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025006459 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 502025006460 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 502025006461 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 502025006462 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 502025006463 Domain of unknown function (DUF427); Region: DUF427; pfam04248 502025006464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025006465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025006466 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 502025006467 substrate binding pocket [chemical binding]; other site 502025006468 dimerization interface [polypeptide binding]; other site 502025006469 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 502025006470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006471 NAD(P) binding site [chemical binding]; other site 502025006472 active site 502025006473 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 502025006474 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 502025006475 metal binding site [ion binding]; metal-binding site 502025006476 dimer interface [polypeptide binding]; other site 502025006477 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 502025006478 ligand binding site [chemical binding]; other site 502025006479 active site 502025006480 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 502025006481 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025006482 ATP binding site [chemical binding]; other site 502025006483 putative Mg++ binding site [ion binding]; other site 502025006484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025006485 nucleotide binding region [chemical binding]; other site 502025006486 ATP-binding site [chemical binding]; other site 502025006487 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 502025006488 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 502025006489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006490 active site 502025006491 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 502025006492 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 502025006493 Ligand Binding Site [chemical binding]; other site 502025006494 TIGR00269 family protein; Region: TIGR00269 502025006495 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 502025006496 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 502025006497 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 502025006498 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 502025006499 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 502025006500 Ligand Binding Site [chemical binding]; other site 502025006501 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 502025006502 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 502025006503 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025006504 catalytic residue [active] 502025006505 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 502025006506 HemN C-terminal domain; Region: HemN_C; pfam06969 502025006507 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 502025006508 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 502025006509 EamA-like transporter family; Region: EamA; pfam00892 502025006510 GrpE; Region: GrpE; pfam01025 502025006511 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 502025006512 dimer interface [polypeptide binding]; other site 502025006513 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 502025006514 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 502025006515 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 502025006516 nucleotide binding site [chemical binding]; other site 502025006517 NEF interaction site [polypeptide binding]; other site 502025006518 SBD interface [polypeptide binding]; other site 502025006519 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025006520 HSP70 interaction site [polypeptide binding]; other site 502025006521 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 502025006522 substrate binding site [polypeptide binding]; other site 502025006523 dimer interface [polypeptide binding]; other site 502025006524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025006525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006526 dimer interface [polypeptide binding]; other site 502025006527 phosphorylation site [posttranslational modification] 502025006528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006529 ATP binding site [chemical binding]; other site 502025006530 Mg2+ binding site [ion binding]; other site 502025006531 G-X-G motif; other site 502025006532 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025006533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006534 active site 502025006535 phosphorylation site [posttranslational modification] 502025006536 intermolecular recognition site; other site 502025006537 dimerization interface [polypeptide binding]; other site 502025006538 Response regulator receiver domain; Region: Response_reg; pfam00072 502025006539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006540 active site 502025006541 phosphorylation site [posttranslational modification] 502025006542 intermolecular recognition site; other site 502025006543 dimerization interface [polypeptide binding]; other site 502025006544 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 502025006545 putative binding surface; other site 502025006546 active site 502025006547 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 502025006548 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 502025006549 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 502025006550 G1 box; other site 502025006551 GTP/Mg2+ binding site [chemical binding]; other site 502025006552 G2 box; other site 502025006553 Switch I region; other site 502025006554 G3 box; other site 502025006555 Switch II region; other site 502025006556 G4 box; other site 502025006557 G5 box; other site 502025006558 large tegument protein UL36; Provisional; Region: PHA03247 502025006559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025006560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006561 dimer interface [polypeptide binding]; other site 502025006562 phosphorylation site [posttranslational modification] 502025006563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006564 ATP binding site [chemical binding]; other site 502025006565 Mg2+ binding site [ion binding]; other site 502025006566 G-X-G motif; other site 502025006567 Domain of unknown function DUF21; Region: DUF21; pfam01595 502025006568 FOG: CBS domain [General function prediction only]; Region: COG0517 502025006569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 502025006570 Domain of unknown function DUF21; Region: DUF21; pfam01595 502025006571 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 502025006572 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 502025006573 Transporter associated domain; Region: CorC_HlyC; smart01091 502025006574 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 502025006575 AIR carboxylase; Region: AIRC; smart01001 502025006576 Protein of unknown function DUF111; Region: DUF111; pfam01969 502025006577 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025006578 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025006579 PAS domain S-box; Region: sensory_box; TIGR00229 502025006580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025006581 putative active site [active] 502025006582 heme pocket [chemical binding]; other site 502025006583 PAS domain S-box; Region: sensory_box; TIGR00229 502025006584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025006585 putative active site [active] 502025006586 heme pocket [chemical binding]; other site 502025006587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006588 phosphorylation site [posttranslational modification] 502025006589 dimer interface [polypeptide binding]; other site 502025006590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025006591 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025006592 putative active site [active] 502025006593 heme pocket [chemical binding]; other site 502025006594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006595 dimer interface [polypeptide binding]; other site 502025006596 phosphorylation site [posttranslational modification] 502025006597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006598 ATP binding site [chemical binding]; other site 502025006599 Mg2+ binding site [ion binding]; other site 502025006600 G-X-G motif; other site 502025006601 putative pectinesterase; Region: PLN02432; cl01911 502025006602 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 502025006603 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 502025006604 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 502025006605 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025006606 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025006607 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025006608 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025006609 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025006610 catalytic loop [active] 502025006611 iron binding site [ion binding]; other site 502025006612 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025006613 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025006614 MAPEG family; Region: MAPEG; pfam01124 502025006615 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025006616 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025006617 PEGA domain; Region: PEGA; pfam08308 502025006618 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025006619 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 502025006620 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025006621 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 502025006622 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 502025006623 ligand binding site [chemical binding]; other site 502025006624 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006625 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006626 active site 502025006627 ATP binding site [chemical binding]; other site 502025006628 substrate binding site [chemical binding]; other site 502025006629 activation loop (A-loop); other site 502025006630 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 502025006631 putative dimer interface [polypeptide binding]; other site 502025006632 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025006633 Helix-turn-helix domain; Region: HTH_18; pfam12833 502025006634 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 502025006635 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 502025006636 putative active site [active] 502025006637 substrate binding site [chemical binding]; other site 502025006638 putative cosubstrate binding site; other site 502025006639 catalytic site [active] 502025006640 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 502025006641 substrate binding site [chemical binding]; other site 502025006642 16S rRNA methyltransferase B; Provisional; Region: PRK14902 502025006643 putative RNA binding site [nucleotide binding]; other site 502025006644 NusB family; Region: NusB; pfam01029 502025006645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025006646 S-adenosylmethionine binding site [chemical binding]; other site 502025006647 Flavodoxin; Region: Flavodoxin_1; pfam00258 502025006648 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 502025006649 FAD binding domain; Region: FAD_binding_1; pfam00667 502025006650 FAD binding pocket [chemical binding]; other site 502025006651 FAD binding motif [chemical binding]; other site 502025006652 catalytic residues [active] 502025006653 NAD binding pocket [chemical binding]; other site 502025006654 phosphate binding motif [ion binding]; other site 502025006655 beta-alpha-beta structure motif; other site 502025006656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025006657 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 502025006658 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025006659 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025006660 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 502025006661 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 502025006662 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 502025006663 substrate binding site [chemical binding]; other site 502025006664 hexamer interface [polypeptide binding]; other site 502025006665 metal binding site [ion binding]; metal-binding site 502025006666 PLD-like domain; Region: PLDc_2; pfam13091 502025006667 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025006668 putative active site [active] 502025006669 catalytic site [active] 502025006670 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025006671 PLD-like domain; Region: PLDc_2; pfam13091 502025006672 putative active site [active] 502025006673 catalytic site [active] 502025006674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025006675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025006676 AAA domain; Region: AAA_21; pfam13304 502025006677 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 502025006678 nucleotide binding site [chemical binding]; other site 502025006679 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 502025006680 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 502025006681 nucleotide binding site [chemical binding]; other site 502025006682 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 502025006683 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 502025006684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 502025006685 Uncharacterized conserved protein [Function unknown]; Region: COG2135 502025006686 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 502025006687 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 502025006688 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 502025006689 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 502025006690 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025006691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006692 active site 502025006693 phosphorylation site [posttranslational modification] 502025006694 intermolecular recognition site; other site 502025006695 dimerization interface [polypeptide binding]; other site 502025006696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006697 Walker A motif; other site 502025006698 ATP binding site [chemical binding]; other site 502025006699 Walker B motif; other site 502025006700 arginine finger; other site 502025006701 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025006702 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 502025006703 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 502025006704 type II secretion system protein D; Region: type_II_gspD; TIGR02517 502025006705 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 502025006706 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 502025006707 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 502025006708 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 502025006709 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025006710 type II secretion system protein E; Region: type_II_gspE; TIGR02533 502025006711 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 502025006712 Walker A motif; other site 502025006713 ATP binding site [chemical binding]; other site 502025006714 Walker B motif; other site 502025006715 type II secretion system protein F; Region: GspF; TIGR02120 502025006716 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 502025006717 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 502025006718 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 502025006719 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 502025006720 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 502025006721 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 502025006722 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 502025006723 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 502025006724 Cell division protein FtsA; Region: FtsA; pfam14450 502025006725 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 502025006726 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 502025006727 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 502025006728 active site 502025006729 catalytic site [active] 502025006730 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 502025006731 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 502025006732 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 502025006733 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025006734 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025006735 active site 502025006736 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 502025006737 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 502025006738 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 502025006739 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 502025006740 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 502025006741 RNA binding site [nucleotide binding]; other site 502025006742 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 502025006743 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 502025006744 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 502025006745 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 502025006746 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 502025006747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025006748 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 502025006749 FeS/SAM binding site; other site 502025006750 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 502025006751 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 502025006752 FMN binding site [chemical binding]; other site 502025006753 dimer interface [polypeptide binding]; other site 502025006754 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025006755 alanine dehydrogenase; Validated; Region: PRK06046 502025006756 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 502025006757 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 502025006758 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 502025006759 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006760 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006761 active site 502025006762 ATP binding site [chemical binding]; other site 502025006763 substrate binding site [chemical binding]; other site 502025006764 activation loop (A-loop); other site 502025006765 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006766 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006767 active site 502025006768 ATP binding site [chemical binding]; other site 502025006769 substrate binding site [chemical binding]; other site 502025006770 activation loop (A-loop); other site 502025006771 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 502025006772 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 502025006773 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025006774 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025006775 phosphopeptide binding site; other site 502025006776 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025006777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025006778 Walker A motif; other site 502025006779 ATP binding site [chemical binding]; other site 502025006780 Walker B motif; other site 502025006781 arginine finger; other site 502025006782 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006783 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006784 active site 502025006785 ATP binding site [chemical binding]; other site 502025006786 substrate binding site [chemical binding]; other site 502025006787 activation loop (A-loop); other site 502025006788 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025006789 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025006790 catalytic residues [active] 502025006791 integral membrane protein; Region: integ_memb_HG; TIGR03954 502025006792 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 502025006793 TPP-binding site [chemical binding]; other site 502025006794 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 502025006795 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 502025006796 PYR/PP interface [polypeptide binding]; other site 502025006797 dimer interface [polypeptide binding]; other site 502025006798 TPP binding site [chemical binding]; other site 502025006799 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025006800 Uncharacterized conserved protein [Function unknown]; Region: COG1434 502025006801 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 502025006802 putative active site [active] 502025006803 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025006804 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 502025006805 PA/protease or protease-like domain interface [polypeptide binding]; other site 502025006806 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 502025006807 Peptidase family M28; Region: Peptidase_M28; pfam04389 502025006808 metal binding site [ion binding]; metal-binding site 502025006809 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025006810 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 502025006811 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 502025006812 active site 502025006813 catalytic site [active] 502025006814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006815 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006816 active site 502025006817 ATP binding site [chemical binding]; other site 502025006818 substrate binding site [chemical binding]; other site 502025006819 activation loop (A-loop); other site 502025006820 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 502025006821 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 502025006822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025006823 putative metal binding site [ion binding]; other site 502025006824 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 502025006825 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 502025006826 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025006827 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006828 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006829 active site 502025006830 ATP binding site [chemical binding]; other site 502025006831 substrate binding site [chemical binding]; other site 502025006832 activation loop (A-loop); other site 502025006833 PEGA domain; Region: PEGA; pfam08308 502025006834 PEGA domain; Region: PEGA; pfam08308 502025006835 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025006836 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006837 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025006838 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006839 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006840 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025006841 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 502025006842 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025006843 catalytic loop [active] 502025006844 iron binding site [ion binding]; other site 502025006845 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 502025006846 active site 502025006847 DNA binding site [nucleotide binding] 502025006848 Protein kinase domain; Region: Pkinase; pfam00069 502025006849 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025006850 active site 502025006851 ATP binding site [chemical binding]; other site 502025006852 substrate binding site [chemical binding]; other site 502025006853 activation loop (A-loop); other site 502025006854 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006855 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006856 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006857 active site 502025006858 ATP binding site [chemical binding]; other site 502025006859 substrate binding site [chemical binding]; other site 502025006860 activation loop (A-loop); other site 502025006861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025006862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006863 dimer interface [polypeptide binding]; other site 502025006864 phosphorylation site [posttranslational modification] 502025006865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006866 ATP binding site [chemical binding]; other site 502025006867 Mg2+ binding site [ion binding]; other site 502025006868 G-X-G motif; other site 502025006869 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 502025006870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025006871 putative active site [active] 502025006872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025006873 heme pocket [chemical binding]; other site 502025006874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025006875 dimer interface [polypeptide binding]; other site 502025006876 phosphorylation site [posttranslational modification] 502025006877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025006878 ATP binding site [chemical binding]; other site 502025006879 Mg2+ binding site [ion binding]; other site 502025006880 G-X-G motif; other site 502025006881 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025006882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025006883 active site 502025006884 phosphorylation site [posttranslational modification] 502025006885 intermolecular recognition site; other site 502025006886 dimerization interface [polypeptide binding]; other site 502025006887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 502025006888 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025006889 hydrophobic ligand binding site; other site 502025006890 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 502025006891 putative active site [active] 502025006892 nucleotide binding site [chemical binding]; other site 502025006893 nudix motif; other site 502025006894 putative metal binding site [ion binding]; other site 502025006895 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 502025006896 galactokinase; Provisional; Region: PRK05101 502025006897 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 502025006898 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 502025006899 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 502025006900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006901 NAD(P) binding site [chemical binding]; other site 502025006902 active site 502025006903 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025006904 active site 502025006905 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025006906 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025006907 NAD(P) binding site [chemical binding]; other site 502025006908 catalytic residues [active] 502025006909 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025006910 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025006911 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025006912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 502025006913 DDE superfamily endonuclease; Region: DDE_3; pfam13358 502025006914 AIPR protein; Region: AIPR; pfam10592 502025006915 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 502025006916 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 502025006917 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 502025006918 active site 502025006919 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 502025006920 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 502025006921 FAD binding site [chemical binding]; other site 502025006922 substrate binding site [chemical binding]; other site 502025006923 catalytic base [active] 502025006924 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 502025006925 Subunit I/III interface [polypeptide binding]; other site 502025006926 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 502025006927 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 502025006928 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 502025006929 Cytochrome c; Region: Cytochrom_C; pfam00034 502025006930 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 502025006931 Cu(I) binding site [ion binding]; other site 502025006932 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 502025006933 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 502025006934 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 502025006935 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025006936 molybdopterin cofactor binding site; other site 502025006937 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 502025006938 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 502025006939 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 502025006940 heme-binding residues [chemical binding]; other site 502025006941 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 502025006942 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 502025006943 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 502025006944 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006945 active site 502025006946 ATP binding site [chemical binding]; other site 502025006947 substrate binding site [chemical binding]; other site 502025006948 activation loop (A-loop); other site 502025006949 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006950 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 502025006951 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 502025006952 Protein of unknown function, DUF481; Region: DUF481; cl01213 502025006953 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 502025006954 ABC1 family; Region: ABC1; cl17513 502025006955 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025006956 Protein of unknown function (DUF938); Region: DUF938; pfam06080 502025006957 Smr domain; Region: Smr; pfam01713 502025006958 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 502025006959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025006960 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 502025006961 hypothetical protein; Provisional; Region: PRK07338 502025006962 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 502025006963 metal binding site [ion binding]; metal-binding site 502025006964 dimer interface [polypeptide binding]; other site 502025006965 thioester reductase domain; Region: Thioester-redct; TIGR01746 502025006966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025006967 NAD(P) binding site [chemical binding]; other site 502025006968 active site 502025006969 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 502025006970 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 502025006971 CoA-binding site [chemical binding]; other site 502025006972 ATP-binding [chemical binding]; other site 502025006973 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 502025006974 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025006975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025006976 binding surface 502025006977 TPR motif; other site 502025006978 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 502025006979 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 502025006980 active site 502025006981 catalytic site [active] 502025006982 metal binding site [ion binding]; metal-binding site 502025006983 spermidine synthase; Provisional; Region: PRK03612 502025006984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025006985 Ion channel; Region: Ion_trans_2; pfam07885 502025006986 sulfotransferase; Region: PLN02164 502025006987 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 502025006988 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 502025006989 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 502025006990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 502025006991 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 502025006992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025006993 motif II; other site 502025006994 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 502025006995 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025006996 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025006997 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025006998 active site 502025006999 ATP binding site [chemical binding]; other site 502025007000 substrate binding site [chemical binding]; other site 502025007001 activation loop (A-loop); other site 502025007002 AAA ATPase domain; Region: AAA_16; pfam13191 502025007003 Predicted ATPase [General function prediction only]; Region: COG3899 502025007004 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 502025007005 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025007006 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025007007 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 502025007008 CTP synthetase; Validated; Region: pyrG; PRK05380 502025007009 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 502025007010 Catalytic site [active] 502025007011 active site 502025007012 UTP binding site [chemical binding]; other site 502025007013 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 502025007014 active site 502025007015 putative oxyanion hole; other site 502025007016 catalytic triad [active] 502025007017 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025007018 HEAT repeats; Region: HEAT_2; pfam13646 502025007019 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 502025007020 protein binding surface [polypeptide binding]; other site 502025007021 HEAT repeats; Region: HEAT_2; pfam13646 502025007022 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 502025007023 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 502025007024 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 502025007025 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 502025007026 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 502025007027 30S subunit binding site; other site 502025007028 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 502025007029 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 502025007030 active site 502025007031 phosphorylation site [posttranslational modification] 502025007032 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 502025007033 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 502025007034 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 502025007035 Hpr binding site; other site 502025007036 active site 502025007037 homohexamer subunit interaction site [polypeptide binding]; other site 502025007038 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 502025007039 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 502025007040 dimerization domain swap beta strand [polypeptide binding]; other site 502025007041 regulatory protein interface [polypeptide binding]; other site 502025007042 active site 502025007043 regulatory phosphorylation site [posttranslational modification]; other site 502025007044 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 502025007045 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 502025007046 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 502025007047 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 502025007048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025007049 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 502025007050 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 502025007051 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007052 active site 502025007053 ATP binding site [chemical binding]; other site 502025007054 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007055 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007056 substrate binding site [chemical binding]; other site 502025007057 activation loop (A-loop); other site 502025007058 AAA ATPase domain; Region: AAA_16; pfam13191 502025007059 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007060 active site 502025007061 ATP binding site [chemical binding]; other site 502025007062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007064 substrate binding site [chemical binding]; other site 502025007065 activation loop (A-loop); other site 502025007066 AAA ATPase domain; Region: AAA_16; pfam13191 502025007067 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025007068 active site 502025007069 DNA binding site [nucleotide binding] 502025007070 Int/Topo IB signature motif; other site 502025007071 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 502025007072 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025007073 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025007074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025007075 non-specific DNA binding site [nucleotide binding]; other site 502025007076 salt bridge; other site 502025007077 sequence-specific DNA binding site [nucleotide binding]; other site 502025007078 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025007079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025007080 sequence-specific DNA binding site [nucleotide binding]; other site 502025007081 salt bridge; other site 502025007082 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025007083 phosphopeptide binding site; other site 502025007084 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007085 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025007086 active site 502025007087 ATP binding site [chemical binding]; other site 502025007088 substrate binding site [chemical binding]; other site 502025007089 activation loop (A-loop); other site 502025007090 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 502025007091 SEFIR domain; Region: SEFIR; pfam08357 502025007092 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007093 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007094 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 502025007095 HsdM N-terminal domain; Region: HsdM_N; pfam12161 502025007096 Methyltransferase domain; Region: Methyltransf_26; pfam13659 502025007097 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 502025007098 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 502025007099 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 502025007100 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 502025007101 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 502025007102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025007103 ATP binding site [chemical binding]; other site 502025007104 putative Mg++ binding site [ion binding]; other site 502025007105 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 502025007106 Protein of unknown function DUF45; Region: DUF45; pfam01863 502025007107 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 502025007108 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025007109 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 502025007110 catalytic residues [active] 502025007111 catalytic nucleophile [active] 502025007112 Presynaptic Site I dimer interface [polypeptide binding]; other site 502025007113 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 502025007114 Synaptic Flat tetramer interface [polypeptide binding]; other site 502025007115 Synaptic Site I dimer interface [polypeptide binding]; other site 502025007116 DNA binding site [nucleotide binding] 502025007117 Recombinase; Region: Recombinase; pfam07508 502025007118 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025007119 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 502025007120 TIGR02677 family protein; Region: TIGR02677 502025007121 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 502025007122 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 502025007123 TIGR02680 family protein; Region: TIGR02680 502025007124 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 502025007125 TIGR02679 family protein; Region: TIGR02679 502025007126 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 502025007127 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025007128 active site 502025007129 catalytic residues [active] 502025007130 DNA binding site [nucleotide binding] 502025007131 Int/Topo IB signature motif; other site 502025007132 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 502025007133 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025007134 metal binding site [ion binding]; metal-binding site 502025007135 N-acetyltransferase; Region: Acetyltransf_2; cl00949 502025007136 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 502025007137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025007138 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 502025007139 substrate binding site [chemical binding]; other site 502025007140 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025007141 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025007142 putative active site pocket [active] 502025007143 dimerization interface [polypeptide binding]; other site 502025007144 putative catalytic residue [active] 502025007145 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025007146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025007147 salt bridge; other site 502025007148 non-specific DNA binding site [nucleotide binding]; other site 502025007149 sequence-specific DNA binding site [nucleotide binding]; other site 502025007150 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007151 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025007152 active site 502025007153 ATP binding site [chemical binding]; other site 502025007154 substrate binding site [chemical binding]; other site 502025007155 activation loop (A-loop); other site 502025007156 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007157 AAA ATPase domain; Region: AAA_16; pfam13191 502025007158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025007159 TPR repeat; Region: TPR_11; pfam13414 502025007160 TPR motif; other site 502025007161 binding surface 502025007162 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025007163 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 502025007164 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025007165 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025007166 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025007167 Annexin; Region: Annexin; pfam00191 502025007168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025007169 dimerization interface [polypeptide binding]; other site 502025007170 putative DNA binding site [nucleotide binding]; other site 502025007171 putative Zn2+ binding site [ion binding]; other site 502025007172 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 502025007173 Sodium Bile acid symporter family; Region: SBF; cl17470 502025007174 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 502025007175 Low molecular weight phosphatase family; Region: LMWPc; cd00115 502025007176 active site 502025007177 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 502025007178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025007179 putative metal binding site [ion binding]; other site 502025007180 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 502025007181 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 502025007182 DNA binding residues [nucleotide binding] 502025007183 dimer interface [polypeptide binding]; other site 502025007184 mercury binding site [ion binding]; other site 502025007185 MerT mercuric transport protein; Region: MerT; cl03578 502025007186 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 502025007187 metal-binding site [ion binding] 502025007188 Heavy-metal-associated domain; Region: HMA; pfam00403 502025007189 metal-binding site [ion binding] 502025007190 Cation efflux family; Region: Cation_efflux; cl00316 502025007191 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 502025007192 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025007193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025007194 S-adenosylmethionine binding site [chemical binding]; other site 502025007195 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025007196 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 502025007197 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 502025007198 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025007199 Outer membrane efflux protein; Region: OEP; pfam02321 502025007200 Outer membrane efflux protein; Region: OEP; pfam02321 502025007201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025007202 dimerization interface [polypeptide binding]; other site 502025007203 putative DNA binding site [nucleotide binding]; other site 502025007204 putative Zn2+ binding site [ion binding]; other site 502025007205 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025007206 putative active site pocket [active] 502025007207 dimerization interface [polypeptide binding]; other site 502025007208 putative catalytic residue [active] 502025007209 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025007210 putative active site pocket [active] 502025007211 dimerization interface [polypeptide binding]; other site 502025007212 putative catalytic residue [active] 502025007213 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025007214 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007215 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025007216 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007217 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007218 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007219 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 502025007220 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 502025007221 Protein of unknown function (DUF1399); Region: DUF1399; pfam07173 502025007222 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 502025007223 Mrr N-terminal domain; Region: Mrr_N; pfam14338 502025007224 Mrr N-terminal domain; Region: Mrr_N; pfam14338 502025007225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007226 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025007227 Walker A motif; other site 502025007228 ATP binding site [chemical binding]; other site 502025007229 Walker B motif; other site 502025007230 arginine finger; other site 502025007231 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 502025007232 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 502025007233 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 502025007234 catalytic residues [active] 502025007235 catalytic nucleophile [active] 502025007236 Presynaptic Site I dimer interface [polypeptide binding]; other site 502025007237 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 502025007238 Synaptic Flat tetramer interface [polypeptide binding]; other site 502025007239 Synaptic Site I dimer interface [polypeptide binding]; other site 502025007240 DNA binding site [nucleotide binding] 502025007241 Recombinase; Region: Recombinase; pfam07508 502025007242 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 502025007243 TIGR02677 family protein; Region: TIGR02677 502025007244 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 502025007245 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 502025007246 TIGR02680 family protein; Region: TIGR02680 502025007247 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 502025007248 TIGR02679 family protein; Region: TIGR02679 502025007249 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 502025007250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007251 Walker A motif; other site 502025007252 ATP binding site [chemical binding]; other site 502025007253 Walker B motif; other site 502025007254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025007255 Integrase core domain; Region: rve; pfam00665 502025007256 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025007257 active site 502025007258 catalytic residues [active] 502025007259 DNA binding site [nucleotide binding] 502025007260 Int/Topo IB signature motif; other site 502025007261 phage tail protein domain; Region: tail_TIGR02242 502025007262 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 502025007263 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025007264 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025007265 putative active site pocket [active] 502025007266 dimerization interface [polypeptide binding]; other site 502025007267 putative catalytic residue [active] 502025007268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025007269 salt bridge; other site 502025007270 non-specific DNA binding site [nucleotide binding]; other site 502025007271 sequence-specific DNA binding site [nucleotide binding]; other site 502025007272 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025007273 phosphopeptide binding site; other site 502025007274 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007275 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025007276 active site 502025007277 ATP binding site [chemical binding]; other site 502025007278 substrate binding site [chemical binding]; other site 502025007279 activation loop (A-loop); other site 502025007280 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 502025007281 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025007282 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025007283 Uncharacterized conserved protein [Function unknown]; Region: COG1262 502025007284 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025007285 Transposase, Mutator family; Region: Transposase_mut; pfam00872 502025007286 MULE transposase domain; Region: MULE; pfam10551 502025007287 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 502025007288 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025007289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007290 Walker A motif; other site 502025007291 ATP binding site [chemical binding]; other site 502025007292 Walker B motif; other site 502025007293 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 502025007294 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025007295 putative active site pocket [active] 502025007296 dimerization interface [polypeptide binding]; other site 502025007297 putative catalytic residue [active] 502025007298 MAEBL; Provisional; Region: PTZ00121 502025007299 Transposase IS200 like; Region: Y1_Tnp; cl00848 502025007300 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 502025007301 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 502025007302 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025007303 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025007304 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 502025007305 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 502025007306 putative active site [active] 502025007307 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025007308 metal binding site [ion binding]; metal-binding site 502025007309 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025007310 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 502025007311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 502025007312 active site 502025007313 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025007314 Annexin; Region: Annexin; pfam00191 502025007315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007316 Walker A motif; other site 502025007317 ATP binding site [chemical binding]; other site 502025007318 Walker B motif; other site 502025007319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025007320 Integrase core domain; Region: rve; pfam00665 502025007321 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025007322 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025007323 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 502025007324 NAD(P) binding site [chemical binding]; other site 502025007325 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 502025007326 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 502025007327 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025007328 dimer interface [polypeptide binding]; other site 502025007329 active site 502025007330 CoA binding pocket [chemical binding]; other site 502025007331 FkbH-like domain; Region: FkbH; TIGR01686 502025007332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025007333 active site 502025007334 motif I; other site 502025007335 motif II; other site 502025007336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025007337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025007338 active site 502025007339 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025007340 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 502025007341 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025007342 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025007343 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007344 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007345 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025007346 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 502025007347 Condensation domain; Region: Condensation; pfam00668 502025007348 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025007349 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025007350 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025007351 acyl-activating enzyme (AAE) consensus motif; other site 502025007352 AMP binding site [chemical binding]; other site 502025007353 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025007354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025007355 S-adenosylmethionine binding site [chemical binding]; other site 502025007356 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025007357 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025007358 Condensation domain; Region: Condensation; pfam00668 502025007359 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007360 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007361 active site 502025007362 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007363 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007364 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025007365 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007366 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007367 active site 502025007368 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007369 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007370 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 502025007371 NADP binding site [chemical binding]; other site 502025007372 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007373 active site 502025007374 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007375 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025007376 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007377 active site 502025007378 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007379 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007380 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007381 putative NADP binding site [chemical binding]; other site 502025007382 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007383 active site 502025007384 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007385 Erythronolide synthase docking; Region: Docking; pfam08990 502025007386 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025007387 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007388 active site 502025007389 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007390 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007391 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007392 putative NADP binding site [chemical binding]; other site 502025007393 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007394 active site 502025007395 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007396 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025007397 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007398 active site 502025007399 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007400 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007401 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007402 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 502025007403 Enoylreductase; Region: PKS_ER; smart00829 502025007404 NAD(P) binding site [chemical binding]; other site 502025007405 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007406 putative NADP binding site [chemical binding]; other site 502025007407 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007408 active site 502025007409 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007410 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007411 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025007412 active site 502025007413 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007414 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007415 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007416 putative NADP binding site [chemical binding]; other site 502025007417 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007418 active site 502025007419 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007420 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007421 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007422 active site 502025007423 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007424 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007425 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007426 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007427 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007428 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007429 putative NADP binding site [chemical binding]; other site 502025007430 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007431 active site 502025007432 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007433 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 502025007434 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007435 active site 502025007436 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007437 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007438 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 502025007439 putative NADP binding site [chemical binding]; other site 502025007440 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007441 active site 502025007442 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007443 Condensation domain; Region: Condensation; pfam00668 502025007444 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 502025007445 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 502025007446 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 502025007447 acyl-activating enzyme (AAE) consensus motif; other site 502025007448 AMP binding site [chemical binding]; other site 502025007449 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025007450 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 502025007451 Integrase core domain; Region: rve; pfam00665 502025007452 Integrase core domain; Region: rve_3; cl15866 502025007453 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025007454 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025007455 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007456 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007457 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007458 Transposase; Region: HTH_Tnp_1; pfam01527 502025007459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 502025007460 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025007461 Cytochrome P450; Region: p450; cl12078 502025007462 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025007463 Cytochrome P450; Region: p450; cl12078 502025007464 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007465 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007466 active site 502025007467 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007468 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007469 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007471 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007472 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007473 putative NADP binding site [chemical binding]; other site 502025007474 active site 502025007475 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007476 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007477 active site 502025007478 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007479 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007480 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007481 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007482 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007483 putative NADP binding site [chemical binding]; other site 502025007484 active site 502025007485 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007486 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007487 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007488 active site 502025007489 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007490 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007491 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007492 putative NADP binding site [chemical binding]; other site 502025007493 KR domain; Region: KR; pfam08659 502025007494 active site 502025007495 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007496 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007497 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007498 active site 502025007499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007500 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 502025007501 Enoylreductase; Region: PKS_ER; smart00829 502025007502 NAD(P) binding site [chemical binding]; other site 502025007503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007504 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 502025007505 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007506 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007507 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007508 active site 502025007509 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007510 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007511 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007512 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007513 putative NADP binding site [chemical binding]; other site 502025007514 KR domain; Region: KR; pfam08659 502025007515 active site 502025007516 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007517 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007518 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007519 active site 502025007520 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007521 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007523 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007524 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007525 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007526 active site 502025007527 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007528 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007529 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007530 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025007531 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007532 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025007533 Cytochrome P450; Region: p450; cl12078 502025007534 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007535 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 502025007536 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 502025007537 active site 502025007538 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007539 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007540 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025007541 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 502025007542 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 502025007543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007544 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025007545 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025007546 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 502025007547 putative NADP binding site [chemical binding]; other site 502025007548 KR domain; Region: KR; pfam08659 502025007549 active site 502025007550 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 502025007551 FAD binding domain; Region: FAD_binding_3; pfam01494 502025007552 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 502025007553 Fatty acid desaturase; Region: FA_desaturase; pfam00487 502025007554 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 502025007555 putative di-iron ligands [ion binding]; other site 502025007556 Cupin; Region: Cupin_6; pfam12852 502025007557 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 502025007558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025007559 SnoaL-like domain; Region: SnoaL_3; pfam13474 502025007560 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 502025007561 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 502025007562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007563 NAD(P) binding site [chemical binding]; other site 502025007564 active site 502025007565 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 502025007566 active site 502025007567 zinc binding site [ion binding]; other site 502025007568 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 502025007569 30S subunit binding site; other site 502025007570 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 502025007571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025007572 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 502025007573 putative dimerization interface [polypeptide binding]; other site 502025007574 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 502025007575 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025007576 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025007577 NADH(P)-binding; Region: NAD_binding_10; pfam13460 502025007578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025007579 NAD(P) binding site [chemical binding]; other site 502025007580 active site 502025007581 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 502025007582 L-lactate permease; Region: Lactate_perm; cl00701 502025007583 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 502025007584 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025007585 molybdopterin cofactor binding site; other site 502025007586 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025007587 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 502025007588 molybdopterin cofactor binding site; other site 502025007589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025007590 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 502025007591 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 502025007592 putative active site [active] 502025007593 putative FMN binding site [chemical binding]; other site 502025007594 putative substrate binding site [chemical binding]; other site 502025007595 putative catalytic residue [active] 502025007596 PAS fold; Region: PAS_4; pfam08448 502025007597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025007598 putative active site [active] 502025007599 heme pocket [chemical binding]; other site 502025007600 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025007601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007602 dimer interface [polypeptide binding]; other site 502025007603 phosphorylation site [posttranslational modification] 502025007604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007605 ATP binding site [chemical binding]; other site 502025007606 Mg2+ binding site [ion binding]; other site 502025007607 G-X-G motif; other site 502025007608 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007610 active site 502025007611 phosphorylation site [posttranslational modification] 502025007612 intermolecular recognition site; other site 502025007613 dimerization interface [polypeptide binding]; other site 502025007614 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 502025007615 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 502025007616 putative active site [active] 502025007617 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 502025007618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025007619 Walker A/P-loop; other site 502025007620 ATP binding site [chemical binding]; other site 502025007621 Q-loop/lid; other site 502025007622 ABC transporter signature motif; other site 502025007623 Walker B; other site 502025007624 D-loop; other site 502025007625 H-loop/switch region; other site 502025007626 HEXXH motif domain; Region: mod_HExxH; TIGR04267 502025007627 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 502025007628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025007629 FeS/SAM binding site; other site 502025007630 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 502025007631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025007632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025007633 WHG domain; Region: WHG; pfam13305 502025007634 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 502025007635 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025007636 Cytochrome P450; Region: p450; pfam00067 502025007637 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 502025007638 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 502025007639 RNA binding site [nucleotide binding]; other site 502025007640 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 502025007641 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 502025007642 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 502025007643 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 502025007644 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 502025007645 metal binding site 2 [ion binding]; metal-binding site 502025007646 putative DNA binding helix; other site 502025007647 metal binding site 1 [ion binding]; metal-binding site 502025007648 dimer interface [polypeptide binding]; other site 502025007649 structural Zn2+ binding site [ion binding]; other site 502025007650 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 502025007651 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 502025007652 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 502025007653 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007654 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007655 active site 502025007656 ATP binding site [chemical binding]; other site 502025007657 substrate binding site [chemical binding]; other site 502025007658 activation loop (A-loop); other site 502025007659 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025007660 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025007661 structural tetrad; other site 502025007662 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025007663 structural tetrad; other site 502025007664 Predicted transcriptional regulators [Transcription]; Region: COG1695 502025007665 Transcriptional regulator PadR-like family; Region: PadR; cl17335 502025007666 DinB family; Region: DinB; cl17821 502025007667 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 502025007668 Helix-turn-helix domain; Region: HTH_17; pfam12728 502025007669 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 502025007670 A new structural DNA glycosylase; Region: AlkD_like; cd06561 502025007671 active site 502025007672 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 502025007673 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 502025007674 homodimer interface [polypeptide binding]; other site 502025007675 substrate-cofactor binding pocket; other site 502025007676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025007677 catalytic residue [active] 502025007678 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 502025007679 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 502025007680 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 502025007681 NADP binding site [chemical binding]; other site 502025007682 Predicted transcriptional regulator [Transcription]; Region: COG1959 502025007683 Transcriptional regulator; Region: Rrf2; pfam02082 502025007684 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 502025007685 acetyl-CoA synthetase; Provisional; Region: PRK04319 502025007686 Protein of unknown function (DUF770); Region: DUF770; cl01402 502025007687 Protein of unknown function (DUF770); Region: DUF770; cl01402 502025007688 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 502025007689 Protein of unknown function (DUF877); Region: DUF877; pfam05943 502025007690 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 502025007691 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 502025007692 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 502025007693 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 502025007694 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 502025007695 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025007696 CotH protein; Region: CotH; pfam08757 502025007697 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 502025007698 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025007699 calcium binding site 2 [ion binding]; other site 502025007700 active site 502025007701 catalytic triad [active] 502025007702 calcium binding site 1 [ion binding]; other site 502025007703 GON domain; Region: GON; pfam08685 502025007704 GON domain; Region: GON; pfam08685 502025007705 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 502025007706 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 502025007707 active site 502025007708 metal binding site [ion binding]; metal-binding site 502025007709 homotetramer interface [polypeptide binding]; other site 502025007710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025007711 S-adenosylmethionine binding site [chemical binding]; other site 502025007712 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 502025007713 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 502025007714 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025007715 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 502025007716 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 502025007717 N- and C-terminal domain interface [polypeptide binding]; other site 502025007718 active site 502025007719 MgATP binding site [chemical binding]; other site 502025007720 catalytic site [active] 502025007721 metal binding site [ion binding]; metal-binding site 502025007722 xylulose binding site [chemical binding]; other site 502025007723 putative homodimer interface [polypeptide binding]; other site 502025007724 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025007725 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025007726 catalytic residue [active] 502025007727 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 502025007728 EamA-like transporter family; Region: EamA; cl17759 502025007729 EamA-like transporter family; Region: EamA; pfam00892 502025007730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 502025007731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025007732 TPR repeat; Region: TPR_11; pfam13414 502025007733 TPR motif; other site 502025007734 binding surface 502025007735 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007736 metal ion-dependent adhesion site (MIDAS); other site 502025007737 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007738 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025007739 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007740 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025007741 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007742 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025007743 hypothetical protein; Provisional; Region: PRK08244 502025007744 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 502025007745 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 502025007746 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 502025007747 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025007748 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025007749 active site 502025007750 catalytic tetrad [active] 502025007751 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 502025007752 SCP-2 sterol transfer family; Region: SCP2; pfam02036 502025007753 Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; Region: PurD; COG0151 502025007754 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 502025007755 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025007756 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 502025007757 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025007758 Beta/Gamma crystallin; Region: Crystall; cl02528 502025007759 Activator of aromatic catabolism; Region: XylR_N; pfam06505 502025007760 V4R domain; Region: V4R; pfam02830 502025007761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007762 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025007763 Walker A motif; other site 502025007764 ATP binding site [chemical binding]; other site 502025007765 Walker B motif; other site 502025007766 arginine finger; other site 502025007767 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025007768 Pirin-related protein [General function prediction only]; Region: COG1741 502025007769 Pirin; Region: Pirin; pfam02678 502025007770 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 502025007771 Isochorismatase family; Region: Isochorismatase; pfam00857 502025007772 catalytic triad [active] 502025007773 dimer interface [polypeptide binding]; other site 502025007774 conserved cis-peptide bond; other site 502025007775 transcriptional regulator TraR; Provisional; Region: PRK13870 502025007776 Autoinducer binding domain; Region: Autoind_bind; pfam03472 502025007777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025007778 DNA binding residues [nucleotide binding] 502025007779 dimerization interface [polypeptide binding]; other site 502025007780 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007781 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025007782 active site 502025007783 ATP binding site [chemical binding]; other site 502025007784 substrate binding site [chemical binding]; other site 502025007785 activation loop (A-loop); other site 502025007786 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007787 AAA ATPase domain; Region: AAA_16; pfam13191 502025007788 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025007789 WD domain, G-beta repeat; Region: WD40; pfam00400 502025007790 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025007791 structural tetrad; other site 502025007792 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025007793 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025007794 structural tetrad; other site 502025007795 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 502025007796 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 502025007797 active site 502025007798 catalytic residues [active] 502025007799 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 502025007800 active site 502025007801 zinc binding site [ion binding]; other site 502025007802 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 502025007803 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 502025007804 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; pfam00339 502025007805 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 502025007806 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 502025007807 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 502025007808 active site 502025007809 Zn binding site [ion binding]; other site 502025007810 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025007811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025007812 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025007813 DNA binding residues [nucleotide binding] 502025007814 Putative zinc-finger; Region: zf-HC2; pfam13490 502025007815 Caspase domain; Region: Peptidase_C14; pfam00656 502025007816 circadian clock protein KaiC; Reviewed; Region: PRK09302 502025007817 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025007818 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025007819 Walker A motif; other site 502025007820 Walker A motif; other site 502025007821 ATP binding site [chemical binding]; other site 502025007822 Walker B motif; other site 502025007823 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025007824 Walker A motif; other site 502025007825 ATP binding site [chemical binding]; other site 502025007826 Walker B motif; other site 502025007827 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 502025007828 tetramer interface [polypeptide binding]; other site 502025007829 dimer interface [polypeptide binding]; other site 502025007830 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025007831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025007832 putative active site [active] 502025007833 heme pocket [chemical binding]; other site 502025007834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007835 dimer interface [polypeptide binding]; other site 502025007836 phosphorylation site [posttranslational modification] 502025007837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007838 ATP binding site [chemical binding]; other site 502025007839 Mg2+ binding site [ion binding]; other site 502025007840 G-X-G motif; other site 502025007841 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007843 active site 502025007844 phosphorylation site [posttranslational modification] 502025007845 intermolecular recognition site; other site 502025007846 dimerization interface [polypeptide binding]; other site 502025007847 Protein of unknown function (DUF805); Region: DUF805; pfam05656 502025007848 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025007849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025007850 Walker A motif; other site 502025007851 ATP binding site [chemical binding]; other site 502025007852 Walker B motif; other site 502025007853 arginine finger; other site 502025007854 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025007855 Protein of unknown function DUF58; Region: DUF58; pfam01882 502025007856 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 502025007857 RDD family; Region: RDD; pfam06271 502025007858 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025007859 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 502025007860 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 502025007861 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025007862 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 502025007863 Walker A/P-loop; other site 502025007864 ATP binding site [chemical binding]; other site 502025007865 Q-loop/lid; other site 502025007866 ABC transporter signature motif; other site 502025007867 Walker B; other site 502025007868 D-loop; other site 502025007869 H-loop/switch region; other site 502025007870 ABC-2 type transporter; Region: ABC2_membrane; cl17235 502025007871 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 502025007872 MarR family; Region: MarR_2; pfam12802 502025007873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025007874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007875 dimer interface [polypeptide binding]; other site 502025007876 phosphorylation site [posttranslational modification] 502025007877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007878 ATP binding site [chemical binding]; other site 502025007879 Mg2+ binding site [ion binding]; other site 502025007880 G-X-G motif; other site 502025007881 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007883 active site 502025007884 phosphorylation site [posttranslational modification] 502025007885 intermolecular recognition site; other site 502025007886 dimerization interface [polypeptide binding]; other site 502025007887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025007888 PAS fold; Region: PAS_3; pfam08447 502025007889 putative active site [active] 502025007890 heme pocket [chemical binding]; other site 502025007891 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025007892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025007893 putative active site [active] 502025007894 heme pocket [chemical binding]; other site 502025007895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007896 dimer interface [polypeptide binding]; other site 502025007897 phosphorylation site [posttranslational modification] 502025007898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007899 ATP binding site [chemical binding]; other site 502025007900 Mg2+ binding site [ion binding]; other site 502025007901 G-X-G motif; other site 502025007902 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007904 active site 502025007905 phosphorylation site [posttranslational modification] 502025007906 intermolecular recognition site; other site 502025007907 dimerization interface [polypeptide binding]; other site 502025007908 Uncharacterized conserved protein [Function unknown]; Region: COG3603 502025007909 Family description; Region: ACT_7; pfam13840 502025007910 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 502025007911 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 502025007912 Walker A/P-loop; other site 502025007913 ATP binding site [chemical binding]; other site 502025007914 Q-loop/lid; other site 502025007915 ABC transporter signature motif; other site 502025007916 Walker B; other site 502025007917 D-loop; other site 502025007918 H-loop/switch region; other site 502025007919 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 502025007920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025007921 dimer interface [polypeptide binding]; other site 502025007922 conserved gate region; other site 502025007923 putative PBP binding loops; other site 502025007924 ABC-ATPase subunit interface; other site 502025007925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025007926 dimer interface [polypeptide binding]; other site 502025007927 conserved gate region; other site 502025007928 putative PBP binding loops; other site 502025007929 ABC-ATPase subunit interface; other site 502025007930 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 502025007931 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 502025007932 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025007933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025007934 ATP binding site [chemical binding]; other site 502025007935 putative Mg++ binding site [ion binding]; other site 502025007936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025007937 nucleotide binding region [chemical binding]; other site 502025007938 ATP-binding site [chemical binding]; other site 502025007939 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 502025007940 putative acyl-acceptor binding pocket; other site 502025007941 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 502025007942 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 502025007943 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 502025007944 TPR repeat; Region: TPR_11; pfam13414 502025007945 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025007946 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025007947 ligand binding site [chemical binding]; other site 502025007948 flexible hinge region; other site 502025007949 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025007950 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025007951 ligand binding site [chemical binding]; other site 502025007952 flexible hinge region; other site 502025007953 Predicted kinase [General function prediction only]; Region: COG0645 502025007954 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 502025007955 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 502025007956 metal binding triad [ion binding]; metal-binding site 502025007957 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 502025007958 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 502025007959 tellurium resistance terB-like protein; Region: terB_like; cd07177 502025007960 metal binding site [ion binding]; metal-binding site 502025007961 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025007962 PAS domain; Region: PAS_8; pfam13188 502025007963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025007964 dimer interface [polypeptide binding]; other site 502025007965 phosphorylation site [posttranslational modification] 502025007966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025007967 ATP binding site [chemical binding]; other site 502025007968 Mg2+ binding site [ion binding]; other site 502025007969 G-X-G motif; other site 502025007970 Response regulator receiver domain; Region: Response_reg; pfam00072 502025007971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025007972 active site 502025007973 phosphorylation site [posttranslational modification] 502025007974 intermolecular recognition site; other site 502025007975 dimerization interface [polypeptide binding]; other site 502025007976 Protein of unknown function (DUF819); Region: DUF819; cl02317 502025007977 FOG: CBS domain [General function prediction only]; Region: COG0517 502025007978 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025007979 FOG: CBS domain [General function prediction only]; Region: COG0517 502025007980 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025007981 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025007982 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 502025007983 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 502025007984 PA/protease or protease-like domain interface [polypeptide binding]; other site 502025007985 Subtilase family; Region: Peptidase_S8; pfam00082 502025007986 catalytic residues [active] 502025007987 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025007988 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025007989 active site 502025007990 ATP binding site [chemical binding]; other site 502025007991 substrate binding site [chemical binding]; other site 502025007992 activation loop (A-loop); other site 502025007993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025007994 TPR motif; other site 502025007995 binding surface 502025007996 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 502025007997 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 502025007998 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025007999 metal ion-dependent adhesion site (MIDAS); other site 502025008000 MG2 domain; Region: A2M_N; pfam01835 502025008001 Alpha-2-macroglobulin family; Region: A2M; pfam00207 502025008002 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 502025008003 surface patch; other site 502025008004 thioester region; other site 502025008005 A-macroglobulin complement component; Region: A2M_comp; pfam07678 502025008006 specificity defining residues; other site 502025008007 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025008008 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 502025008009 NADP+ binding site [chemical binding]; other site 502025008010 folate binding site [chemical binding]; other site 502025008011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025008012 ATP binding site [chemical binding]; other site 502025008013 putative Mg++ binding site [ion binding]; other site 502025008014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025008015 nucleotide binding region [chemical binding]; other site 502025008016 ATP-binding site [chemical binding]; other site 502025008017 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025008018 Ligand Binding Site [chemical binding]; other site 502025008019 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025008020 Ligand Binding Site [chemical binding]; other site 502025008021 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 502025008022 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025008023 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025008024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025008025 Walker A motif; other site 502025008026 ATP binding site [chemical binding]; other site 502025008027 Walker B motif; other site 502025008028 arginine finger; other site 502025008029 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025008030 Protein of unknown function DUF58; Region: DUF58; pfam01882 502025008031 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 502025008032 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 502025008033 von Willebrand factor type A domain; Region: VWA_2; pfam13519 502025008034 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 502025008035 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 502025008036 DNA repair protein RadA; Provisional; Region: PRK11823 502025008037 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025008038 Walker A motif; other site 502025008039 ATP binding site [chemical binding]; other site 502025008040 Walker B motif; other site 502025008041 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 502025008042 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025008043 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025008044 phosphopeptide binding site; other site 502025008045 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 502025008046 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 502025008047 substrate binding pocket [chemical binding]; other site 502025008048 Ion channel; Region: Ion_trans_2; pfam07885 502025008049 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 502025008050 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 502025008051 membrane-bound complex binding site; other site 502025008052 hinge residues; other site 502025008053 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 502025008054 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 502025008055 dimer interface [polypeptide binding]; other site 502025008056 anticodon binding site; other site 502025008057 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 502025008058 homodimer interface [polypeptide binding]; other site 502025008059 motif 1; other site 502025008060 active site 502025008061 motif 2; other site 502025008062 GAD domain; Region: GAD; pfam02938 502025008063 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 502025008064 motif 3; other site 502025008065 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 502025008066 ligand-binding site [chemical binding]; other site 502025008067 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 502025008068 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 502025008069 Active Sites [active] 502025008070 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 502025008071 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 502025008072 active site 502025008073 HIGH motif; other site 502025008074 nucleotide binding site [chemical binding]; other site 502025008075 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 502025008076 active site 502025008077 KMSKS motif; other site 502025008078 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 502025008079 tRNA binding surface [nucleotide binding]; other site 502025008080 anticodon binding site; other site 502025008081 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 502025008082 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 502025008083 Sel1-like repeats; Region: SEL1; smart00671 502025008084 Sel1-like repeats; Region: SEL1; smart00671 502025008085 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 502025008086 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025008087 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025008088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025008089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 502025008090 Peptidase M15; Region: Peptidase_M15_3; cl01194 502025008091 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025008092 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 502025008093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025008094 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 502025008095 Walker A/P-loop; other site 502025008096 ATP binding site [chemical binding]; other site 502025008097 Q-loop/lid; other site 502025008098 ABC transporter signature motif; other site 502025008099 Walker B; other site 502025008100 D-loop; other site 502025008101 H-loop/switch region; other site 502025008102 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 502025008103 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 502025008104 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 502025008105 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 502025008106 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025008107 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 502025008108 acyl-activating enzyme (AAE) consensus motif; other site 502025008109 putative AMP binding site [chemical binding]; other site 502025008110 putative active site [active] 502025008111 putative CoA binding site [chemical binding]; other site 502025008112 Conserved TM helix; Region: TM_helix; pfam05552 502025008113 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025008114 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025008115 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025008116 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 502025008117 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 502025008118 NMT1/THI5 like; Region: NMT1; pfam09084 502025008119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008120 PAS fold; Region: PAS_3; pfam08447 502025008121 putative active site [active] 502025008122 heme pocket [chemical binding]; other site 502025008123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008124 dimer interface [polypeptide binding]; other site 502025008125 phosphorylation site [posttranslational modification] 502025008126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008127 ATP binding site [chemical binding]; other site 502025008128 Mg2+ binding site [ion binding]; other site 502025008129 G-X-G motif; other site 502025008130 Response regulator receiver domain; Region: Response_reg; pfam00072 502025008131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008132 active site 502025008133 phosphorylation site [posttranslational modification] 502025008134 intermolecular recognition site; other site 502025008135 dimerization interface [polypeptide binding]; other site 502025008136 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 502025008137 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 502025008138 putative active site [active] 502025008139 putative PHP Thumb interface [polypeptide binding]; other site 502025008140 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 502025008141 generic binding surface II; other site 502025008142 generic binding surface I; other site 502025008143 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 502025008144 DNA Polymerase Y-family; Region: PolY_like; cd03468 502025008145 active site 502025008146 DNA binding site [nucleotide binding] 502025008147 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025008148 Walker A motif; other site 502025008149 ATP binding site [chemical binding]; other site 502025008150 Walker B motif; other site 502025008151 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 502025008152 serine O-acetyltransferase; Region: cysE; TIGR01172 502025008153 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 502025008154 trimer interface [polypeptide binding]; other site 502025008155 active site 502025008156 substrate binding site [chemical binding]; other site 502025008157 CoA binding site [chemical binding]; other site 502025008158 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008159 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008160 active site 502025008161 ATP binding site [chemical binding]; other site 502025008162 substrate binding site [chemical binding]; other site 502025008163 activation loop (A-loop); other site 502025008164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008165 TPR motif; other site 502025008166 binding surface 502025008167 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 502025008168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 502025008169 putative acyl-acceptor binding pocket; other site 502025008170 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 502025008171 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025008172 putative NAD(P) binding site [chemical binding]; other site 502025008173 active site 502025008174 putative substrate binding site [chemical binding]; other site 502025008175 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 502025008176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008177 ATP binding site [chemical binding]; other site 502025008178 Mg2+ binding site [ion binding]; other site 502025008179 G-X-G motif; other site 502025008180 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 502025008181 ATP binding site [chemical binding]; other site 502025008182 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 502025008183 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 502025008184 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 502025008185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025008186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 502025008187 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 502025008188 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 502025008189 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 502025008190 homodimer interface [polypeptide binding]; other site 502025008191 NADP binding site [chemical binding]; other site 502025008192 substrate binding site [chemical binding]; other site 502025008193 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025008194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008195 active site 502025008196 phosphorylation site [posttranslational modification] 502025008197 intermolecular recognition site; other site 502025008198 dimerization interface [polypeptide binding]; other site 502025008199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025008200 Walker A motif; other site 502025008201 ATP binding site [chemical binding]; other site 502025008202 Walker B motif; other site 502025008203 arginine finger; other site 502025008204 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 502025008205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008206 dimer interface [polypeptide binding]; other site 502025008207 phosphorylation site [posttranslational modification] 502025008208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008209 ATP binding site [chemical binding]; other site 502025008210 Mg2+ binding site [ion binding]; other site 502025008211 G-X-G motif; other site 502025008212 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 502025008213 Ca2+ binding site [ion binding]; other site 502025008214 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 502025008215 EF-hand domain pair; Region: EF_hand_5; pfam13499 502025008216 Ca2+ binding site [ion binding]; other site 502025008217 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025008218 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025008219 active site 502025008220 catalytic tetrad [active] 502025008221 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 502025008222 Family description; Region: VCBS; pfam13517 502025008223 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 502025008224 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 502025008225 dinuclear metal binding motif [ion binding]; other site 502025008226 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025008227 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 502025008228 DNA binding residues [nucleotide binding] 502025008229 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 502025008230 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 502025008231 FAD binding pocket [chemical binding]; other site 502025008232 FAD binding motif [chemical binding]; other site 502025008233 phosphate binding motif [ion binding]; other site 502025008234 beta-alpha-beta structure motif; other site 502025008235 NAD(p) ribose binding residues [chemical binding]; other site 502025008236 NAD binding pocket [chemical binding]; other site 502025008237 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 502025008238 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025008239 catalytic loop [active] 502025008240 iron binding site [ion binding]; other site 502025008241 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025008242 putative active site [active] 502025008243 putative metal binding site [ion binding]; other site 502025008244 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 502025008245 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008246 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008247 active site 502025008248 ATP binding site [chemical binding]; other site 502025008249 substrate binding site [chemical binding]; other site 502025008250 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008251 substrate binding site [chemical binding]; other site 502025008252 activation loop (A-loop); other site 502025008253 activation loop (A-loop); other site 502025008254 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008256 TPR motif; other site 502025008257 binding surface 502025008258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008259 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008261 binding surface 502025008262 TPR motif; other site 502025008263 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008264 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008266 binding surface 502025008267 TPR motif; other site 502025008268 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008269 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008270 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025008271 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 502025008272 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 502025008273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025008274 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025008275 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 502025008276 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 502025008277 E3 interaction surface; other site 502025008278 lipoyl attachment site [posttranslational modification]; other site 502025008279 e3 binding domain; Region: E3_binding; pfam02817 502025008280 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 502025008281 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 502025008282 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 502025008283 alpha subunit interface [polypeptide binding]; other site 502025008284 TPP binding site [chemical binding]; other site 502025008285 heterodimer interface [polypeptide binding]; other site 502025008286 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025008287 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 502025008288 TPP-binding site [chemical binding]; other site 502025008289 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 502025008290 SnoaL-like domain; Region: SnoaL_3; pfam13474 502025008291 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 502025008292 IHF dimer interface [polypeptide binding]; other site 502025008293 IHF - DNA interface [nucleotide binding]; other site 502025008294 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 502025008295 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 502025008296 3D domain; Region: 3D; cl01439 502025008297 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 502025008298 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 502025008299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025008300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 502025008301 FIST N domain; Region: FIST; pfam08495 502025008302 FIST C domain; Region: FIST_C; pfam10442 502025008303 TPR repeat; Region: TPR_11; pfam13414 502025008304 TPR repeat; Region: TPR_11; pfam13414 502025008305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008306 binding surface 502025008307 TPR motif; other site 502025008308 fatty acyl-CoA reductase; Region: PLN02996 502025008309 Male sterility protein; Region: NAD_binding_4; pfam07993 502025008310 NAD(P) binding site [chemical binding]; other site 502025008311 active site 502025008312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025008313 active site 502025008314 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 502025008315 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025008316 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025008317 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 502025008318 acyl-activating enzyme (AAE) consensus motif; other site 502025008319 putative AMP binding site [chemical binding]; other site 502025008320 putative active site [active] 502025008321 putative CoA binding site [chemical binding]; other site 502025008322 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025008323 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 502025008324 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 502025008325 putative acyl-acceptor binding pocket; other site 502025008326 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 502025008327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025008328 NAD(P) binding site [chemical binding]; other site 502025008329 active site 502025008330 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 502025008331 CheB methylesterase; Region: CheB_methylest; pfam01339 502025008332 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025008333 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025008334 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 502025008335 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 502025008336 PAS domain; Region: PAS_10; pfam13596 502025008337 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025008338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008339 putative active site [active] 502025008340 heme pocket [chemical binding]; other site 502025008341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008342 dimer interface [polypeptide binding]; other site 502025008343 phosphorylation site [posttranslational modification] 502025008344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008345 ATP binding site [chemical binding]; other site 502025008346 Mg2+ binding site [ion binding]; other site 502025008347 G-X-G motif; other site 502025008348 Response regulator receiver domain; Region: Response_reg; pfam00072 502025008349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008350 active site 502025008351 phosphorylation site [posttranslational modification] 502025008352 intermolecular recognition site; other site 502025008353 dimerization interface [polypeptide binding]; other site 502025008354 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025008355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008356 active site 502025008357 phosphorylation site [posttranslational modification] 502025008358 intermolecular recognition site; other site 502025008359 dimerization interface [polypeptide binding]; other site 502025008360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 502025008361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008362 dimer interface [polypeptide binding]; other site 502025008363 phosphorylation site [posttranslational modification] 502025008364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008365 ATP binding site [chemical binding]; other site 502025008366 Mg2+ binding site [ion binding]; other site 502025008367 G-X-G motif; other site 502025008368 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 502025008369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008370 phosphorylation site [posttranslational modification] 502025008371 intermolecular recognition site; other site 502025008372 CheB methylesterase; Region: CheB_methylest; pfam01339 502025008373 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 502025008374 putative binding surface; other site 502025008375 active site 502025008376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008377 ATP binding site [chemical binding]; other site 502025008378 Mg2+ binding site [ion binding]; other site 502025008379 G-X-G motif; other site 502025008380 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 502025008381 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025008382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008383 active site 502025008384 phosphorylation site [posttranslational modification] 502025008385 intermolecular recognition site; other site 502025008386 dimerization interface [polypeptide binding]; other site 502025008387 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 502025008388 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 502025008389 dimer interface [polypeptide binding]; other site 502025008390 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 502025008391 putative CheW interface [polypeptide binding]; other site 502025008392 CheW-like domain; Region: CheW; pfam01584 502025008393 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 502025008394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025008395 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 502025008396 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 502025008397 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 502025008398 nucleotide binding site [chemical binding]; other site 502025008399 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 502025008400 active site 502025008401 hydrophilic channel; other site 502025008402 dimerization interface [polypeptide binding]; other site 502025008403 catalytic residues [active] 502025008404 active site lid [active] 502025008405 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 502025008406 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025008407 metal ion-dependent adhesion site (MIDAS); other site 502025008408 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 502025008409 Protein of unknown function DUF58; Region: DUF58; pfam01882 502025008410 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025008411 metal ion-dependent adhesion site (MIDAS); other site 502025008412 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025008413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025008414 Walker A motif; other site 502025008415 ATP binding site [chemical binding]; other site 502025008416 Walker B motif; other site 502025008417 arginine finger; other site 502025008418 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 502025008419 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 502025008420 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 502025008421 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 502025008422 Preprotein translocase SecG subunit; Region: SecG; pfam03840 502025008423 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 502025008424 triosephosphate isomerase; Provisional; Region: PRK14567 502025008425 substrate binding site [chemical binding]; other site 502025008426 dimer interface [polypeptide binding]; other site 502025008427 catalytic triad [active] 502025008428 Phosphoglycerate kinase; Region: PGK; pfam00162 502025008429 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 502025008430 substrate binding site [chemical binding]; other site 502025008431 hinge regions; other site 502025008432 ADP binding site [chemical binding]; other site 502025008433 catalytic site [active] 502025008434 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 502025008435 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 502025008436 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 502025008437 PilZ domain; Region: PilZ; pfam07238 502025008438 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 502025008439 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 502025008440 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025008441 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025008442 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 502025008443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025008444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025008445 homodimer interface [polypeptide binding]; other site 502025008446 catalytic residue [active] 502025008447 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 502025008448 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 502025008449 catalytic motif [active] 502025008450 Zn binding site [ion binding]; other site 502025008451 RibD C-terminal domain; Region: RibD_C; cl17279 502025008452 CheB methylesterase; Region: CheB_methylest; pfam01339 502025008453 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025008454 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025008455 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 502025008456 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 502025008457 PAS domain; Region: PAS_10; pfam13596 502025008458 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025008459 GAF domain; Region: GAF; pfam01590 502025008460 PAS fold; Region: PAS_3; pfam08447 502025008461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008462 heme pocket [chemical binding]; other site 502025008463 putative active site [active] 502025008464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008465 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 502025008466 putative active site [active] 502025008467 heme pocket [chemical binding]; other site 502025008468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008469 putative active site [active] 502025008470 heme pocket [chemical binding]; other site 502025008471 PAS domain S-box; Region: sensory_box; TIGR00229 502025008472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008473 putative active site [active] 502025008474 heme pocket [chemical binding]; other site 502025008475 PAS domain S-box; Region: sensory_box; TIGR00229 502025008476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025008477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008478 dimer interface [polypeptide binding]; other site 502025008479 phosphorylation site [posttranslational modification] 502025008480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008481 ATP binding site [chemical binding]; other site 502025008482 Mg2+ binding site [ion binding]; other site 502025008483 G-X-G motif; other site 502025008484 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025008485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008486 active site 502025008487 phosphorylation site [posttranslational modification] 502025008488 intermolecular recognition site; other site 502025008489 dimerization interface [polypeptide binding]; other site 502025008490 Domain of unknown function DUF59; Region: DUF59; cl00941 502025008491 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 502025008492 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 502025008493 trimerization site [polypeptide binding]; other site 502025008494 active site 502025008495 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025008496 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 502025008497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025008498 catalytic residue [active] 502025008499 FeS assembly protein SufD; Region: sufD; TIGR01981 502025008500 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 502025008501 FeS assembly ATPase SufC; Region: sufC; TIGR01978 502025008502 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 502025008503 Walker A/P-loop; other site 502025008504 ATP binding site [chemical binding]; other site 502025008505 Q-loop/lid; other site 502025008506 ABC transporter signature motif; other site 502025008507 Walker B; other site 502025008508 D-loop; other site 502025008509 H-loop/switch region; other site 502025008510 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 502025008511 putative ABC transporter; Region: ycf24; CHL00085 502025008512 Rrf2 family protein; Region: rrf2_super; TIGR00738 502025008513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025008514 putative Zn2+ binding site [ion binding]; other site 502025008515 putative DNA binding site [nucleotide binding]; other site 502025008516 Transcriptional regulator; Region: Rrf2; cl17282 502025008517 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 502025008518 rRNA binding site [nucleotide binding]; other site 502025008519 predicted 30S ribosome binding site; other site 502025008520 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 502025008521 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 502025008522 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 502025008523 23S rRNA interface [nucleotide binding]; other site 502025008524 L7/L12 interface [polypeptide binding]; other site 502025008525 putative thiostrepton binding site; other site 502025008526 L25 interface [polypeptide binding]; other site 502025008527 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 502025008528 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 502025008529 FMN binding site [chemical binding]; other site 502025008530 active site 502025008531 substrate binding site [chemical binding]; other site 502025008532 catalytic residue [active] 502025008533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025008534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025008535 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025008536 putative effector binding pocket; other site 502025008537 dimerization interface [polypeptide binding]; other site 502025008538 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 502025008539 putative active site [active] 502025008540 metal binding site [ion binding]; metal-binding site 502025008541 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 502025008542 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 502025008543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025008544 motif II; other site 502025008545 RF-1 domain; Region: RF-1; cl17422 502025008546 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 502025008547 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008548 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008549 active site 502025008550 ATP binding site [chemical binding]; other site 502025008551 substrate binding site [chemical binding]; other site 502025008552 activation loop (A-loop); other site 502025008553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025008554 Walker A/P-loop; other site 502025008555 ATP binding site [chemical binding]; other site 502025008556 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025008557 WD domain, G-beta repeat; Region: WD40; pfam00400 502025008558 WD domain, G-beta repeat; Region: WD40; pfam00400 502025008559 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025008560 structural tetrad; other site 502025008561 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008562 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008563 active site 502025008564 ATP binding site [chemical binding]; other site 502025008565 substrate binding site [chemical binding]; other site 502025008566 activation loop (A-loop); other site 502025008567 AAA ATPase domain; Region: AAA_16; pfam13191 502025008568 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025008569 structural tetrad; other site 502025008570 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025008571 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025008572 structural tetrad; other site 502025008573 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025008574 structural tetrad; other site 502025008575 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 502025008576 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 502025008577 lipoyl attachment site [posttranslational modification]; other site 502025008578 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 502025008579 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 502025008580 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 502025008581 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 502025008582 classical (c) SDRs; Region: SDR_c; cd05233 502025008583 NAD(P) binding site [chemical binding]; other site 502025008584 active site 502025008585 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025008586 nudix motif; other site 502025008587 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025008588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008589 active site 502025008590 phosphorylation site [posttranslational modification] 502025008591 intermolecular recognition site; other site 502025008592 dimerization interface [polypeptide binding]; other site 502025008593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025008594 Walker A motif; other site 502025008595 ATP binding site [chemical binding]; other site 502025008596 Walker B motif; other site 502025008597 arginine finger; other site 502025008598 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025008599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025008600 dimerization interface [polypeptide binding]; other site 502025008601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008602 dimer interface [polypeptide binding]; other site 502025008603 phosphorylation site [posttranslational modification] 502025008604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008605 ATP binding site [chemical binding]; other site 502025008606 Mg2+ binding site [ion binding]; other site 502025008607 G-X-G motif; other site 502025008608 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025008609 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 502025008610 mce related protein; Region: MCE; pfam02470 502025008611 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 502025008612 mce related protein; Region: MCE; pfam02470 502025008613 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 502025008614 Domain of unknown function DUF20; Region: UPF0118; pfam01594 502025008615 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 502025008616 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025008617 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025008618 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025008619 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025008620 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025008621 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025008622 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025008623 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025008624 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025008625 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025008626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025008627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025008628 DNA binding residues [nucleotide binding] 502025008629 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 502025008630 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 502025008631 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 502025008632 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 502025008633 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025008634 CBD_II domain; Region: CBD_II; smart00637 502025008635 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008636 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008637 active site 502025008638 ATP binding site [chemical binding]; other site 502025008639 substrate binding site [chemical binding]; other site 502025008640 activation loop (A-loop); other site 502025008641 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 502025008642 cyclase homology domain; Region: CHD; cd07302 502025008643 dimer interface [polypeptide binding]; other site 502025008644 nucleotidyl binding site; other site 502025008645 metal binding site [ion binding]; metal-binding site 502025008646 AAA ATPase domain; Region: AAA_16; pfam13191 502025008647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 502025008648 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 502025008649 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025008650 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025008651 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 502025008652 FAD binding domain; Region: FAD_binding_4; pfam01565 502025008653 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 502025008654 FAD binding domain; Region: FAD_binding_4; pfam01565 502025008655 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 502025008656 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 502025008657 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 502025008658 protein binding site [polypeptide binding]; other site 502025008659 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 502025008660 Biofilm formation and stress response factor; Region: BsmA; pfam10014 502025008661 Family description; Region: VCBS; pfam13517 502025008662 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 502025008663 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 502025008664 putative DNA binding site [nucleotide binding]; other site 502025008665 putative homodimer interface [polypeptide binding]; other site 502025008666 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 502025008667 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 502025008668 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 502025008669 active site 502025008670 DNA binding site [nucleotide binding] 502025008671 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 502025008672 DNA binding site [nucleotide binding] 502025008673 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 502025008674 nucleotide binding site [chemical binding]; other site 502025008675 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008676 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025008677 active site 502025008678 ATP binding site [chemical binding]; other site 502025008679 substrate binding site [chemical binding]; other site 502025008680 activation loop (A-loop); other site 502025008681 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 502025008682 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 502025008683 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025008684 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025008685 active site 502025008686 metal binding site [ion binding]; metal-binding site 502025008687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025008688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025008689 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 502025008690 substrate binding pocket [chemical binding]; other site 502025008691 dimerization interface [polypeptide binding]; other site 502025008692 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 502025008693 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 502025008694 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 502025008695 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 502025008696 cheY-homologous receiver domain; Region: REC; smart00448 502025008697 phosphorylation site [posttranslational modification] 502025008698 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025008699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008700 ATP binding site [chemical binding]; other site 502025008701 Mg2+ binding site [ion binding]; other site 502025008702 G-X-G motif; other site 502025008703 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 502025008704 putative hexamer interface [polypeptide binding]; other site 502025008705 putative hexagonal pore; other site 502025008706 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 502025008707 Hexamer interface [polypeptide binding]; other site 502025008708 Hexagonal pore residue; other site 502025008709 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 502025008710 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 502025008711 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025008712 Ligand Binding Site [chemical binding]; other site 502025008713 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025008714 Protein phosphatase 2C; Region: PP2C; pfam00481 502025008715 active site 502025008716 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025008717 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025008718 ligand binding site [chemical binding]; other site 502025008719 flexible hinge region; other site 502025008720 cyclase homology domain; Region: CHD; cd07302 502025008721 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 502025008722 nucleotidyl binding site; other site 502025008723 metal binding site [ion binding]; metal-binding site 502025008724 dimer interface [polypeptide binding]; other site 502025008725 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 502025008726 cyclase homology domain; Region: CHD; cd07302 502025008727 nucleotidyl binding site; other site 502025008728 metal binding site [ion binding]; metal-binding site 502025008729 dimer interface [polypeptide binding]; other site 502025008730 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025008731 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025008732 DNA adenine methylase (dam); Region: dam; TIGR00571 502025008733 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 502025008734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025008735 FeS/SAM binding site; other site 502025008736 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 502025008737 CcmE; Region: CcmE; cl00994 502025008738 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 502025008739 Cytochrome C biogenesis protein; Region: CcmH; cl01179 502025008740 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025008741 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 502025008742 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025008743 Walker A/P-loop; other site 502025008744 ATP binding site [chemical binding]; other site 502025008745 Q-loop/lid; other site 502025008746 ABC transporter signature motif; other site 502025008747 Walker B; other site 502025008748 D-loop; other site 502025008749 H-loop/switch region; other site 502025008750 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008751 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008752 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008753 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008754 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008755 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 502025008756 CcmB protein; Region: CcmB; cl17444 502025008757 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 502025008758 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008759 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008760 active site 502025008761 ATP binding site [chemical binding]; other site 502025008762 substrate binding site [chemical binding]; other site 502025008763 activation loop (A-loop); other site 502025008764 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025008765 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025008766 active site 502025008767 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 502025008768 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 502025008769 homodimer interface [polypeptide binding]; other site 502025008770 substrate-cofactor binding pocket; other site 502025008771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025008772 catalytic residue [active] 502025008773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008774 binding surface 502025008775 TPR motif; other site 502025008776 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025008777 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025008778 ligand binding site [chemical binding]; other site 502025008779 flexible hinge region; other site 502025008780 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025008781 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025008782 ligand binding site [chemical binding]; other site 502025008783 flexible hinge region; other site 502025008784 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 502025008785 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 502025008786 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 502025008787 motif 1; other site 502025008788 dimer interface [polypeptide binding]; other site 502025008789 active site 502025008790 motif 2; other site 502025008791 motif 3; other site 502025008792 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 502025008793 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 502025008794 pyruvate phosphate dikinase; Provisional; Region: PRK09279 502025008795 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 502025008796 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 502025008797 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 502025008798 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025008799 Sporulation related domain; Region: SPOR; pfam05036 502025008800 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 502025008801 ABC-2 type transporter; Region: ABC2_membrane; cl17235 502025008802 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025008803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025008804 Walker A/P-loop; other site 502025008805 ATP binding site [chemical binding]; other site 502025008806 Q-loop/lid; other site 502025008807 ABC transporter signature motif; other site 502025008808 Walker B; other site 502025008809 D-loop; other site 502025008810 H-loop/switch region; other site 502025008811 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 502025008812 amidase catalytic site [active] 502025008813 Zn binding residues [ion binding]; other site 502025008814 substrate binding site [chemical binding]; other site 502025008815 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025008816 metal ion-dependent adhesion site (MIDAS); other site 502025008817 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025008818 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025008819 phosphopeptide binding site; other site 502025008820 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025008821 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025008822 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025008823 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 502025008824 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 502025008825 putative RNA binding site [nucleotide binding]; other site 502025008826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025008827 S-adenosylmethionine binding site [chemical binding]; other site 502025008828 Protein of unknown function (DUF620); Region: DUF620; pfam04788 502025008829 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 502025008830 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 502025008831 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 502025008832 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025008833 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 502025008834 Transglycosylase; Region: Transgly; pfam00912 502025008835 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 502025008836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008837 binding surface 502025008838 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025008839 TPR motif; other site 502025008840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025008841 TPR motif; other site 502025008842 binding surface 502025008843 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025008844 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025008845 active site 502025008846 ATP binding site [chemical binding]; other site 502025008847 substrate binding site [chemical binding]; other site 502025008848 activation loop (A-loop); other site 502025008849 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 502025008850 recombination factor protein RarA; Reviewed; Region: PRK13342 502025008851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025008852 Walker A motif; other site 502025008853 ATP binding site [chemical binding]; other site 502025008854 Walker B motif; other site 502025008855 arginine finger; other site 502025008856 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 502025008857 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 502025008858 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025008859 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 502025008860 substrate binding pocket [chemical binding]; other site 502025008861 substrate-Mg2+ binding site; other site 502025008862 aspartate-rich region 1; other site 502025008863 aspartate-rich region 2; other site 502025008864 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 502025008865 active site lid residues [active] 502025008866 substrate binding pocket [chemical binding]; other site 502025008867 catalytic residues [active] 502025008868 substrate-Mg2+ binding site; other site 502025008869 aspartate-rich region 1; other site 502025008870 aspartate-rich region 2; other site 502025008871 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 502025008872 homodimer interface [polypeptide binding]; other site 502025008873 catalytic residues [active] 502025008874 NAD binding site [chemical binding]; other site 502025008875 substrate binding pocket [chemical binding]; other site 502025008876 flexible flap; other site 502025008877 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 502025008878 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 502025008879 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 502025008880 diphosphomevalonate decarboxylase; Region: PLN02407 502025008881 mevalonate kinase; Region: mevalon_kin; TIGR00549 502025008882 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 502025008883 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 502025008884 homotetramer interface [polypeptide binding]; other site 502025008885 FMN binding site [chemical binding]; other site 502025008886 homodimer contacts [polypeptide binding]; other site 502025008887 putative active site [active] 502025008888 putative substrate binding site [chemical binding]; other site 502025008889 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 502025008890 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 502025008891 homodimer interface [polypeptide binding]; other site 502025008892 substrate-cofactor binding pocket; other site 502025008893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025008894 catalytic residue [active] 502025008895 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 502025008896 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 502025008897 active site 502025008898 catalytic triad [active] 502025008899 dimer interface [polypeptide binding]; other site 502025008900 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 502025008901 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025008902 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025008903 active site 502025008904 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 502025008905 Inward rectifier potassium channel; Region: IRK; pfam01007 502025008906 PEGA domain; Region: PEGA; pfam08308 502025008907 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 502025008908 MutS domain I; Region: MutS_I; pfam01624 502025008909 MutS domain II; Region: MutS_II; pfam05188 502025008910 MutS domain III; Region: MutS_III; pfam05192 502025008911 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 502025008912 Walker A/P-loop; other site 502025008913 ATP binding site [chemical binding]; other site 502025008914 Q-loop/lid; other site 502025008915 ABC transporter signature motif; other site 502025008916 Walker B; other site 502025008917 D-loop; other site 502025008918 H-loop/switch region; other site 502025008919 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 502025008920 CheB methylesterase; Region: CheB_methylest; pfam01339 502025008921 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025008922 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 502025008923 PAS domain; Region: PAS_10; pfam13596 502025008924 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 502025008925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008926 putative active site [active] 502025008927 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 502025008928 heme pocket [chemical binding]; other site 502025008929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025008930 putative active site [active] 502025008931 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 502025008932 heme pocket [chemical binding]; other site 502025008933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025008934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025008935 dimer interface [polypeptide binding]; other site 502025008936 phosphorylation site [posttranslational modification] 502025008937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025008938 ATP binding site [chemical binding]; other site 502025008939 Mg2+ binding site [ion binding]; other site 502025008940 G-X-G motif; other site 502025008941 Response regulator receiver domain; Region: Response_reg; pfam00072 502025008942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008943 active site 502025008944 phosphorylation site [posttranslational modification] 502025008945 intermolecular recognition site; other site 502025008946 dimerization interface [polypeptide binding]; other site 502025008947 methionine sulfoxide reductase A; Provisional; Region: PRK14054 502025008948 Response regulator receiver domain; Region: Response_reg; pfam00072 502025008949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025008950 active site 502025008951 phosphorylation site [posttranslational modification] 502025008952 intermolecular recognition site; other site 502025008953 dimerization interface [polypeptide binding]; other site 502025008954 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 502025008955 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 502025008956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025008957 active site 502025008958 5' nucleotidase family; Region: 5_nucleotid; cl17687 502025008959 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 502025008960 Peptidase family M23; Region: Peptidase_M23; pfam01551 502025008961 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 502025008962 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 502025008963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025008964 Walker A/P-loop; other site 502025008965 ATP binding site [chemical binding]; other site 502025008966 Q-loop/lid; other site 502025008967 ABC transporter signature motif; other site 502025008968 Walker B; other site 502025008969 D-loop; other site 502025008970 H-loop/switch region; other site 502025008971 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 502025008972 Permease; Region: Permease; pfam02405 502025008973 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 502025008974 Permease; Region: Permease; pfam02405 502025008975 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 502025008976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025008977 Walker A/P-loop; other site 502025008978 ATP binding site [chemical binding]; other site 502025008979 Q-loop/lid; other site 502025008980 ABC transporter signature motif; other site 502025008981 Walker B; other site 502025008982 D-loop; other site 502025008983 H-loop/switch region; other site 502025008984 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 502025008985 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 502025008986 tetramer interface [polypeptide binding]; other site 502025008987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025008988 catalytic residue [active] 502025008989 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 502025008990 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 502025008991 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 502025008992 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 502025008993 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 502025008994 signal recognition particle protein; Provisional; Region: PRK10867 502025008995 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 502025008996 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 502025008997 P loop; other site 502025008998 GTP binding site [chemical binding]; other site 502025008999 Signal peptide binding domain; Region: SRP_SPB; pfam02978 502025009000 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 502025009001 active site 502025009002 SAM binding site [chemical binding]; other site 502025009003 homodimer interface [polypeptide binding]; other site 502025009004 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 502025009005 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 502025009006 active site 502025009007 Lamin Tail Domain; Region: LTD; pfam00932 502025009008 CotH protein; Region: CotH; pfam08757 502025009009 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 502025009010 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 502025009011 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025009012 dimer interface [polypeptide binding]; other site 502025009013 active site 502025009014 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 502025009015 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025009016 substrate binding site [chemical binding]; other site 502025009017 oxyanion hole (OAH) forming residues; other site 502025009018 trimer interface [polypeptide binding]; other site 502025009019 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025009020 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025009021 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; pfam00058 502025009022 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 502025009023 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 502025009024 GMP synthase; Reviewed; Region: guaA; PRK00074 502025009025 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 502025009026 AMP/PPi binding site [chemical binding]; other site 502025009027 candidate oxyanion hole; other site 502025009028 catalytic triad [active] 502025009029 potential glutamine specificity residues [chemical binding]; other site 502025009030 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 502025009031 ATP Binding subdomain [chemical binding]; other site 502025009032 Ligand Binding sites [chemical binding]; other site 502025009033 Dimerization subdomain; other site 502025009034 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025009035 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 502025009036 Walker A/P-loop; other site 502025009037 ATP binding site [chemical binding]; other site 502025009038 Q-loop/lid; other site 502025009039 ABC transporter signature motif; other site 502025009040 Walker B; other site 502025009041 D-loop; other site 502025009042 H-loop/switch region; other site 502025009043 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025009044 FtsX-like permease family; Region: FtsX; pfam02687 502025009045 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009046 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009047 active site 502025009048 ATP binding site [chemical binding]; other site 502025009049 substrate binding site [chemical binding]; other site 502025009050 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009051 substrate binding site [chemical binding]; other site 502025009052 activation loop (A-loop); other site 502025009053 activation loop (A-loop); other site 502025009054 PEGA domain; Region: PEGA; pfam08308 502025009055 PEGA domain; Region: PEGA; pfam08308 502025009056 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 502025009057 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025009058 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025009059 phosphopeptide binding site; other site 502025009060 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025009061 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 502025009062 Walker A motif; other site 502025009063 ATP binding site [chemical binding]; other site 502025009064 Walker B motif; other site 502025009065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009066 TPR motif; other site 502025009067 binding surface 502025009068 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025009069 Double zinc ribbon; Region: DZR; pfam12773 502025009070 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 502025009071 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025009072 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025009073 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025009074 phosphopeptide binding site; other site 502025009075 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025009076 active site 502025009077 Double zinc ribbon; Region: DZR; pfam12773 502025009078 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 502025009079 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009080 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009081 active site 502025009082 ATP binding site [chemical binding]; other site 502025009083 substrate binding site [chemical binding]; other site 502025009084 activation loop (A-loop); other site 502025009085 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 502025009086 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 502025009087 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 502025009088 active site 502025009089 HIGH motif; other site 502025009090 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 502025009091 tRNA binding surface [nucleotide binding]; other site 502025009092 anticodon binding site; other site 502025009093 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009094 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009095 active site 502025009096 ATP binding site [chemical binding]; other site 502025009097 substrate binding site [chemical binding]; other site 502025009098 activation loop (A-loop); other site 502025009099 Response regulator receiver domain; Region: Response_reg; pfam00072 502025009100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025009101 active site 502025009102 phosphorylation site [posttranslational modification] 502025009103 intermolecular recognition site; other site 502025009104 dimerization interface [polypeptide binding]; other site 502025009105 Isochorismatase family; Region: Isochorismatase; pfam00857 502025009106 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 502025009107 catalytic triad [active] 502025009108 dimer interface [polypeptide binding]; other site 502025009109 conserved cis-peptide bond; other site 502025009110 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 502025009111 Lumazine binding domain; Region: Lum_binding; pfam00677 502025009112 Lumazine binding domain; Region: Lum_binding; pfam00677 502025009113 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 502025009114 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 502025009115 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 502025009116 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 502025009117 homopentamer interface [polypeptide binding]; other site 502025009118 active site 502025009119 transcription antitermination factor NusB; Region: nusB; TIGR01951 502025009120 putative RNA binding site [nucleotide binding]; other site 502025009121 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 502025009122 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 502025009123 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 502025009124 substrate-cofactor binding pocket; other site 502025009125 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 502025009126 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 502025009127 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025009128 catalytic residues [active] 502025009129 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009131 active site 502025009132 ATP binding site [chemical binding]; other site 502025009133 substrate binding site [chemical binding]; other site 502025009134 activation loop (A-loop); other site 502025009135 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009137 binding surface 502025009138 TPR motif; other site 502025009139 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009140 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009141 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009142 active site 502025009143 ATP binding site [chemical binding]; other site 502025009144 substrate binding site [chemical binding]; other site 502025009145 activation loop (A-loop); other site 502025009146 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 502025009147 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 502025009148 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 502025009149 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025009150 catalytic core [active] 502025009151 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 502025009152 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 502025009153 tetramer interface [polypeptide binding]; other site 502025009154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025009155 catalytic residue [active] 502025009156 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009157 active site 502025009158 ATP binding site [chemical binding]; other site 502025009159 activation loop (A-loop); other site 502025009160 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 502025009161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025009162 active site 502025009163 phosphorylation site [posttranslational modification] 502025009164 intermolecular recognition site; other site 502025009165 dimerization interface [polypeptide binding]; other site 502025009166 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 502025009167 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 502025009168 helix-hairpin-helix signature motif; other site 502025009169 substrate binding pocket [chemical binding]; other site 502025009170 active site 502025009171 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 502025009172 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 502025009173 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 502025009174 putative NAD(P) binding site [chemical binding]; other site 502025009175 short chain dehydrogenase; Provisional; Region: PRK06500 502025009176 classical (c) SDRs; Region: SDR_c; cd05233 502025009177 NAD(P) binding site [chemical binding]; other site 502025009178 active site 502025009179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025009180 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025009181 PilZ domain; Region: PilZ; cl01260 502025009182 PilZ domain; Region: PilZ; pfam07238 502025009183 Protein of unknown function (DUF721); Region: DUF721; pfam05258 502025009184 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 502025009185 active site 502025009186 putative catalytic site [active] 502025009187 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025009188 putative metal binding site [ion binding]; other site 502025009189 putative phosphate binding site [ion binding]; other site 502025009190 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025009191 catalytic core [active] 502025009192 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 502025009193 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025009194 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025009195 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025009196 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025009197 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025009198 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025009199 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025009200 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025009201 Uncharacterized conserved protein [Function unknown]; Region: COG2006 502025009202 Domain of unknown function (DUF362); Region: DUF362; pfam04015 502025009203 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025009204 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 502025009205 acyl-activating enzyme (AAE) consensus motif; other site 502025009206 putative AMP binding site [chemical binding]; other site 502025009207 putative active site [active] 502025009208 putative CoA binding site [chemical binding]; other site 502025009209 threonine dehydratase; Validated; Region: PRK08639 502025009210 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025009211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025009212 putative active site [active] 502025009213 heme pocket [chemical binding]; other site 502025009214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025009215 dimer interface [polypeptide binding]; other site 502025009216 phosphorylation site [posttranslational modification] 502025009217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025009218 ATP binding site [chemical binding]; other site 502025009219 Mg2+ binding site [ion binding]; other site 502025009220 G-X-G motif; other site 502025009221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025009222 active site 502025009223 phosphorylation site [posttranslational modification] 502025009224 intermolecular recognition site; other site 502025009225 dimerization interface [polypeptide binding]; other site 502025009226 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 502025009227 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 502025009228 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025009229 Zn2+ binding site [ion binding]; other site 502025009230 Mg2+ binding site [ion binding]; other site 502025009231 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025009232 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025009233 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025009234 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 502025009235 FtsX-like permease family; Region: FtsX; pfam02687 502025009236 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025009237 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 502025009238 FtsX-like permease family; Region: FtsX; pfam02687 502025009239 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025009240 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 502025009241 Walker A/P-loop; other site 502025009242 ATP binding site [chemical binding]; other site 502025009243 Q-loop/lid; other site 502025009244 ABC transporter signature motif; other site 502025009245 Walker B; other site 502025009246 D-loop; other site 502025009247 H-loop/switch region; other site 502025009248 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 502025009249 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 502025009250 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 502025009251 putative catalytic residue [active] 502025009252 OsmC-like protein; Region: OsmC; pfam02566 502025009253 Protein of unknown function (DUF507); Region: DUF507; cl01112 502025009254 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 502025009255 active site 502025009256 8-oxo-dGMP binding site [chemical binding]; other site 502025009257 nudix motif; other site 502025009258 metal binding site [ion binding]; metal-binding site 502025009259 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 502025009260 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 502025009261 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 502025009262 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 502025009263 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 502025009264 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 502025009265 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 502025009266 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 502025009267 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 502025009268 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 502025009269 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 502025009270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025009271 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009273 active site 502025009274 ATP binding site [chemical binding]; other site 502025009275 substrate binding site [chemical binding]; other site 502025009276 activation loop (A-loop); other site 502025009277 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 502025009278 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 502025009279 Ligand Binding Site [chemical binding]; other site 502025009280 ribonuclease III; Reviewed; Region: rnc; PRK00102 502025009281 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 502025009282 dimerization interface [polypeptide binding]; other site 502025009283 active site 502025009284 metal binding site [ion binding]; metal-binding site 502025009285 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 502025009286 dsRNA binding site [nucleotide binding]; other site 502025009287 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 502025009288 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 502025009289 Ligand Binding Site [chemical binding]; other site 502025009290 FtsH Extracellular; Region: FtsH_ext; pfam06480 502025009291 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 502025009292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025009293 Walker A motif; other site 502025009294 ATP binding site [chemical binding]; other site 502025009295 Walker B motif; other site 502025009296 arginine finger; other site 502025009297 Peptidase family M41; Region: Peptidase_M41; pfam01434 502025009298 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 502025009299 dihydropteroate synthase; Region: DHPS; TIGR01496 502025009300 substrate binding pocket [chemical binding]; other site 502025009301 dimer interface [polypeptide binding]; other site 502025009302 inhibitor binding site; inhibition site 502025009303 Uncharacterized conserved protein [Function unknown]; Region: COG1624 502025009304 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 502025009305 YbbR-like protein; Region: YbbR; pfam07949 502025009306 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 502025009307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025009308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025009309 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 502025009310 active site 502025009311 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 502025009312 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 502025009313 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 502025009314 PGAP1-like protein; Region: PGAP1; pfam07819 502025009315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009316 binding surface 502025009317 TPR motif; other site 502025009318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009319 TPR motif; other site 502025009320 binding surface 502025009321 Helix-turn-helix domain; Region: HTH_25; pfam13413 502025009322 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 502025009323 Recombination protein O N terminal; Region: RecO_N; pfam11967 502025009324 Recombination protein O C terminal; Region: RecO_C; pfam02565 502025009325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009326 TPR motif; other site 502025009327 PEGA domain; Region: PEGA; pfam08308 502025009328 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 502025009329 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 502025009330 Ca2+ binding site [ion binding]; other site 502025009331 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025009332 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025009333 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025009334 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 502025009335 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025009336 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 502025009337 Outer membrane efflux protein; Region: OEP; pfam02321 502025009338 Outer membrane efflux protein; Region: OEP; pfam02321 502025009339 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009340 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009341 active site 502025009342 ATP binding site [chemical binding]; other site 502025009343 substrate binding site [chemical binding]; other site 502025009344 activation loop (A-loop); other site 502025009345 cyclase homology domain; Region: CHD; cd07302 502025009346 dimer interface [polypeptide binding]; other site 502025009347 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 502025009348 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009349 active site 502025009350 ATP binding site [chemical binding]; other site 502025009351 substrate binding site [chemical binding]; other site 502025009352 activation loop (A-loop); other site 502025009353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009354 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009356 TPR motif; other site 502025009357 binding surface 502025009358 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009359 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009360 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009361 Tetratricopeptide repeat; Region: TPR_10; pfam13374 502025009362 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009363 Penicillin amidase; Region: Penicil_amidase; pfam01804 502025009364 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 502025009365 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 502025009366 active site 502025009367 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 502025009368 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025009369 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 502025009370 acyl-activating enzyme (AAE) consensus motif; other site 502025009371 putative AMP binding site [chemical binding]; other site 502025009372 putative active site [active] 502025009373 putative CoA binding site [chemical binding]; other site 502025009374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025009375 Coenzyme A binding pocket [chemical binding]; other site 502025009376 Sterol carrier protein domain; Region: SCP2_2; pfam13530 502025009377 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 502025009378 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 502025009379 hinge; other site 502025009380 active site 502025009381 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 502025009382 anthranilate synthase component I; Provisional; Region: PRK13565 502025009383 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 502025009384 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 502025009385 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 502025009386 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 502025009387 glutamine binding [chemical binding]; other site 502025009388 catalytic triad [active] 502025009389 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 502025009390 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 502025009391 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 502025009392 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 502025009393 active site 502025009394 ribulose/triose binding site [chemical binding]; other site 502025009395 phosphate binding site [ion binding]; other site 502025009396 substrate (anthranilate) binding pocket [chemical binding]; other site 502025009397 product (indole) binding pocket [chemical binding]; other site 502025009398 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 502025009399 active site 502025009400 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 502025009401 dimer interface [polypeptide binding]; other site 502025009402 Citrate synthase; Region: Citrate_synt; pfam00285 502025009403 active site 502025009404 citrylCoA binding site [chemical binding]; other site 502025009405 NADH binding [chemical binding]; other site 502025009406 cationic pore residues; other site 502025009407 oxalacetate/citrate binding site [chemical binding]; other site 502025009408 coenzyme A binding site [chemical binding]; other site 502025009409 catalytic triad [active] 502025009410 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 502025009411 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 502025009412 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 502025009413 TAP-like protein; Region: Abhydrolase_4; pfam08386 502025009414 Fructosamine kinase; Region: Fructosamin_kin; cl17579 502025009415 Phosphotransferase enzyme family; Region: APH; pfam01636 502025009416 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 502025009417 Low molecular weight phosphatase family; Region: LMWPc; cd00115 502025009418 active site 502025009419 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 502025009420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025009421 active site 502025009422 motif I; other site 502025009423 motif II; other site 502025009424 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 502025009425 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 502025009426 active site 502025009427 catalytic residues [active] 502025009428 metal binding site [ion binding]; metal-binding site 502025009429 enoyl-CoA hydratase; Provisional; Region: PRK07657 502025009430 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025009431 substrate binding site [chemical binding]; other site 502025009432 oxyanion hole (OAH) forming residues; other site 502025009433 trimer interface [polypeptide binding]; other site 502025009434 Bacitracin resistance protein BacA; Region: BacA; pfam02673 502025009435 PEGA domain; Region: PEGA; pfam08308 502025009436 PEGA domain; Region: PEGA; pfam08308 502025009437 PEGA domain; Region: PEGA; pfam08308 502025009438 PEGA domain; Region: PEGA; pfam08308 502025009439 PEGA domain; Region: PEGA; pfam08308 502025009440 PEGA domain; Region: PEGA; pfam08308 502025009441 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025009442 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 502025009443 putative NAD(P) binding site [chemical binding]; other site 502025009444 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 502025009445 RibD C-terminal domain; Region: RibD_C; cl17279 502025009446 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 502025009447 active site 502025009448 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025009449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025009450 S-adenosylmethionine binding site [chemical binding]; other site 502025009451 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 502025009452 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 502025009453 active site 502025009454 substrate binding site [chemical binding]; other site 502025009455 metal binding site [ion binding]; metal-binding site 502025009456 putative carbohydrate kinase; Provisional; Region: PRK10565 502025009457 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 502025009458 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 502025009459 putative substrate binding site [chemical binding]; other site 502025009460 putative ATP binding site [chemical binding]; other site 502025009461 RNA polymerase subunit; Provisional; Region: PHA02998 502025009462 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 502025009463 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 502025009464 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 502025009465 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 502025009466 phage tail protein domain; Region: tail_TIGR02242 502025009467 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025009468 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025009469 phosphopeptide binding site; other site 502025009470 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025009471 metal ion-dependent adhesion site (MIDAS); other site 502025009472 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025009473 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025009474 phosphopeptide binding site; other site 502025009475 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025009476 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025009477 phosphopeptide binding site; other site 502025009478 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025009479 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025009480 phosphopeptide binding site; other site 502025009481 Ycf46; Provisional; Region: ycf46; CHL00195 502025009482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025009483 Walker A motif; other site 502025009484 ATP binding site [chemical binding]; other site 502025009485 Walker B motif; other site 502025009486 arginine finger; other site 502025009487 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 502025009488 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 502025009489 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025009490 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 502025009491 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 502025009492 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025009493 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 502025009494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025009496 binding surface 502025009497 TPR motif; other site 502025009498 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025009499 Protein phosphatase 2C; Region: PP2C; pfam00481 502025009500 active site 502025009501 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009502 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009503 active site 502025009504 ATP binding site [chemical binding]; other site 502025009505 substrate binding site [chemical binding]; other site 502025009506 activation loop (A-loop); other site 502025009507 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025009508 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 502025009509 Putative Catalytic site; other site 502025009510 DXD motif; other site 502025009511 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 502025009512 hydrophobic ligand binding site; other site 502025009513 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 502025009514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025009515 motif II; other site 502025009516 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 502025009517 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009518 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009519 active site 502025009520 ATP binding site [chemical binding]; other site 502025009521 substrate binding site [chemical binding]; other site 502025009522 activation loop (A-loop); other site 502025009523 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 502025009524 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 502025009525 catalytic triad [active] 502025009526 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009527 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009528 active site 502025009529 ATP binding site [chemical binding]; other site 502025009530 substrate binding site [chemical binding]; other site 502025009531 activation loop (A-loop); other site 502025009532 AAA ATPase domain; Region: AAA_16; pfam13191 502025009533 Predicted ATPase [General function prediction only]; Region: COG3899 502025009534 NAD synthetase; Reviewed; Region: nadE; PRK02628 502025009535 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 502025009536 active site 502025009537 catalytic triad [active] 502025009538 multimer interface [polypeptide binding]; other site 502025009539 protein interface 1 [polypeptide binding]; other site 502025009540 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 502025009541 homodimer interface [polypeptide binding]; other site 502025009542 NAD binding pocket [chemical binding]; other site 502025009543 ATP binding pocket [chemical binding]; other site 502025009544 Mg binding site [ion binding]; other site 502025009545 active-site loop [active] 502025009546 Predicted membrane protein [Function unknown]; Region: COG2259 502025009547 seryl-tRNA synthetase; Provisional; Region: PRK05431 502025009548 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 502025009549 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 502025009550 motif 1; other site 502025009551 dimer interface [polypeptide binding]; other site 502025009552 active site 502025009553 motif 2; other site 502025009554 motif 3; other site 502025009555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025009556 Walker A/P-loop; other site 502025009557 ATP binding site [chemical binding]; other site 502025009558 Q-loop/lid; other site 502025009559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025009560 ABC transporter signature motif; other site 502025009561 Walker B; other site 502025009562 D-loop; other site 502025009563 H-loop/switch region; other site 502025009564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025009565 Walker A/P-loop; other site 502025009566 ATP binding site [chemical binding]; other site 502025009567 Q-loop/lid; other site 502025009568 ABC transporter signature motif; other site 502025009569 Walker B; other site 502025009570 D-loop; other site 502025009571 H-loop/switch region; other site 502025009572 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 502025009573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025009574 ABC transporter signature motif; other site 502025009575 Walker B; other site 502025009576 D-loop; other site 502025009577 H-loop/switch region; other site 502025009578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025009579 Walker A/P-loop; other site 502025009580 ATP binding site [chemical binding]; other site 502025009581 Q-loop/lid; other site 502025009582 ABC transporter signature motif; other site 502025009583 Walker B; other site 502025009584 D-loop; other site 502025009585 H-loop/switch region; other site 502025009586 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 502025009587 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025009588 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025009589 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025009590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025009591 Walker A motif; other site 502025009592 ATP binding site [chemical binding]; other site 502025009593 Walker B motif; other site 502025009594 arginine finger; other site 502025009595 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025009596 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 502025009597 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 502025009598 nucleotide binding site [chemical binding]; other site 502025009599 putative NEF/HSP70 interaction site [polypeptide binding]; other site 502025009600 SBD interface [polypeptide binding]; other site 502025009601 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 502025009602 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 502025009603 DnaJ domain; Region: DnaJ; pfam00226 502025009604 HSP70 interaction site [polypeptide binding]; other site 502025009605 Helix-turn-helix domain; Region: HTH_25; pfam13413 502025009606 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 502025009607 GTP1/OBG; Region: GTP1_OBG; pfam01018 502025009608 Obg GTPase; Region: Obg; cd01898 502025009609 G1 box; other site 502025009610 GTP/Mg2+ binding site [chemical binding]; other site 502025009611 Switch I region; other site 502025009612 G2 box; other site 502025009613 G3 box; other site 502025009614 Switch II region; other site 502025009615 G4 box; other site 502025009616 G5 box; other site 502025009617 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 502025009618 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 502025009619 Walker A/P-loop; other site 502025009620 ATP binding site [chemical binding]; other site 502025009621 Q-loop/lid; other site 502025009622 ABC transporter signature motif; other site 502025009623 Walker B; other site 502025009624 D-loop; other site 502025009625 H-loop/switch region; other site 502025009626 Uncharacterized conserved protein [Function unknown]; Region: COG2006 502025009627 Domain of unknown function (DUF362); Region: DUF362; pfam04015 502025009628 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 502025009629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009630 binding surface 502025009631 TPR motif; other site 502025009632 Rhomboid family; Region: Rhomboid; pfam01694 502025009633 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 502025009634 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 502025009635 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 502025009636 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 502025009637 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 502025009638 dimer interface [polypeptide binding]; other site 502025009639 [2Fe-2S] cluster binding site [ion binding]; other site 502025009640 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 502025009641 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 502025009642 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 502025009643 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 502025009644 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 502025009645 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 502025009646 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 502025009647 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 502025009648 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 502025009649 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 502025009650 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025009651 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025009652 phosphopeptide binding site; other site 502025009653 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025009654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025009655 Walker A motif; other site 502025009656 ATP binding site [chemical binding]; other site 502025009657 Walker B motif; other site 502025009658 arginine finger; other site 502025009659 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009660 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009661 active site 502025009662 ATP binding site [chemical binding]; other site 502025009663 substrate binding site [chemical binding]; other site 502025009664 activation loop (A-loop); other site 502025009665 PEGA domain; Region: PEGA; pfam08308 502025009666 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 502025009667 Interdomain contacts; other site 502025009668 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 502025009669 Interdomain contacts; other site 502025009670 Cytokine receptor motif; other site 502025009671 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 502025009672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025009673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025009674 DNA binding residues [nucleotide binding] 502025009675 HEAT repeats; Region: HEAT_2; pfam13646 502025009676 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 502025009677 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 502025009678 protein binding surface [polypeptide binding]; other site 502025009679 HEAT repeats; Region: HEAT_2; pfam13646 502025009680 HEAT repeats; Region: HEAT_2; pfam13646 502025009681 TPR repeat; Region: TPR_11; pfam13414 502025009682 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 502025009683 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025009684 Zn2+ binding site [ion binding]; other site 502025009685 Mg2+ binding site [ion binding]; other site 502025009686 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025009687 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009688 active site 502025009689 ATP binding site [chemical binding]; other site 502025009690 substrate binding site [chemical binding]; other site 502025009691 activation loop (A-loop); other site 502025009692 VanW like protein; Region: VanW; pfam04294 502025009693 G5 domain; Region: G5; pfam07501 502025009694 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 502025009695 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025009696 Sulfatase; Region: Sulfatase; pfam00884 502025009697 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 502025009698 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025009699 Ligand binding site; other site 502025009700 Putative Catalytic site; other site 502025009701 DXD motif; other site 502025009702 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 502025009703 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 502025009704 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 502025009705 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 502025009706 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 502025009707 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 502025009708 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 502025009709 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 502025009710 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 502025009711 Surface antigen; Region: Bac_surface_Ag; pfam01103 502025009712 Family of unknown function (DUF490); Region: DUF490; pfam04357 502025009713 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025009714 protein binding site [polypeptide binding]; other site 502025009715 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 502025009716 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 502025009717 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 502025009718 P loop; other site 502025009719 GTP binding site [chemical binding]; other site 502025009720 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025009721 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025009722 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 502025009723 Walker A/P-loop; other site 502025009724 ATP binding site [chemical binding]; other site 502025009725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025009726 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 502025009727 Q-loop/lid; other site 502025009728 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 502025009729 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 502025009730 ABC transporter signature motif; other site 502025009731 Walker B; other site 502025009732 D-loop; other site 502025009733 H-loop/switch region; other site 502025009734 lipoyl synthase; Provisional; Region: PRK05481 502025009735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025009736 FeS/SAM binding site; other site 502025009737 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 502025009738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025009739 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025009740 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 502025009741 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 502025009742 E3 interaction surface; other site 502025009743 lipoyl attachment site [posttranslational modification]; other site 502025009744 e3 binding domain; Region: E3_binding; pfam02817 502025009745 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 502025009746 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 502025009747 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 502025009748 alpha subunit interface [polypeptide binding]; other site 502025009749 TPP binding site [chemical binding]; other site 502025009750 heterodimer interface [polypeptide binding]; other site 502025009751 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025009752 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 502025009753 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 502025009754 tetramer interface [polypeptide binding]; other site 502025009755 TPP-binding site [chemical binding]; other site 502025009756 heterodimer interface [polypeptide binding]; other site 502025009757 phosphorylation loop region [posttranslational modification] 502025009758 HEAT repeats; Region: HEAT_2; pfam13646 502025009759 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 502025009760 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025009761 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 502025009762 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 502025009763 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 502025009764 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 502025009765 active site 502025009766 (T/H)XGH motif; other site 502025009767 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 502025009768 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 502025009769 dimer interface [polypeptide binding]; other site 502025009770 [2Fe-2S] cluster binding site [ion binding]; other site 502025009771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009772 binding surface 502025009773 TPR motif; other site 502025009774 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025009775 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025009776 ligand binding site [chemical binding]; other site 502025009777 flexible hinge region; other site 502025009778 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025009779 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025009780 ligand binding site [chemical binding]; other site 502025009781 flexible hinge region; other site 502025009782 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025009783 GAF domain; Region: GAF; pfam01590 502025009784 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 502025009785 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 502025009786 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025009787 catalytic residue [active] 502025009788 GTPase Era; Reviewed; Region: era; PRK00089 502025009789 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 502025009790 G1 box; other site 502025009791 GTP/Mg2+ binding site [chemical binding]; other site 502025009792 Switch I region; other site 502025009793 G2 box; other site 502025009794 Switch II region; other site 502025009795 G3 box; other site 502025009796 G4 box; other site 502025009797 G5 box; other site 502025009798 KH domain; Region: KH_2; pfam07650 502025009799 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 502025009800 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 502025009801 G1 box; other site 502025009802 GTP/Mg2+ binding site [chemical binding]; other site 502025009803 Switch I region; other site 502025009804 G2 box; other site 502025009805 Switch II region; other site 502025009806 G3 box; other site 502025009807 G4 box; other site 502025009808 G5 box; other site 502025009809 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 502025009810 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 502025009811 G1 box; other site 502025009812 GTP/Mg2+ binding site [chemical binding]; other site 502025009813 Switch I region; other site 502025009814 G2 box; other site 502025009815 G3 box; other site 502025009816 Switch II region; other site 502025009817 G4 box; other site 502025009818 G5 box; other site 502025009819 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 502025009820 Trp docking motif [polypeptide binding]; other site 502025009821 active site 502025009822 PQQ-like domain; Region: PQQ_2; pfam13360 502025009823 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 502025009824 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 502025009825 putative active site; other site 502025009826 putative metal binding residues [ion binding]; other site 502025009827 putative triphosphate binding site [ion binding]; other site 502025009828 signature motif; other site 502025009829 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 502025009830 Transcriptional regulators [Transcription]; Region: MarR; COG1846 502025009831 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025009832 putative DNA binding site [nucleotide binding]; other site 502025009833 dimerization interface [polypeptide binding]; other site 502025009834 putative Zn2+ binding site [ion binding]; other site 502025009835 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 502025009836 active site 502025009837 catalytic triad [active] 502025009838 dimer interface [polypeptide binding]; other site 502025009839 Response regulator receiver domain; Region: Response_reg; pfam00072 502025009840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025009841 active site 502025009842 phosphorylation site [posttranslational modification] 502025009843 intermolecular recognition site; other site 502025009844 dimerization interface [polypeptide binding]; other site 502025009845 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025009846 active site 502025009847 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 502025009848 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 502025009849 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 502025009850 DNA binding residues [nucleotide binding] 502025009851 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 502025009852 IHF dimer interface [polypeptide binding]; other site 502025009853 IHF - DNA interface [nucleotide binding]; other site 502025009854 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 502025009855 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 502025009856 putative tRNA-binding site [nucleotide binding]; other site 502025009857 B3/4 domain; Region: B3_4; pfam03483 502025009858 tRNA synthetase B5 domain; Region: B5; pfam03484 502025009859 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 502025009860 dimer interface [polypeptide binding]; other site 502025009861 motif 1; other site 502025009862 motif 3; other site 502025009863 motif 2; other site 502025009864 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 502025009865 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 502025009866 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 502025009867 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 502025009868 dimer interface [polypeptide binding]; other site 502025009869 motif 1; other site 502025009870 active site 502025009871 motif 2; other site 502025009872 motif 3; other site 502025009873 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 502025009874 23S rRNA binding site [nucleotide binding]; other site 502025009875 L21 binding site [polypeptide binding]; other site 502025009876 L13 binding site [polypeptide binding]; other site 502025009877 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 502025009878 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009879 Protein kinase domain; Region: Pkinase; pfam00069 502025009880 active site 502025009881 ATP binding site [chemical binding]; other site 502025009882 substrate binding site [chemical binding]; other site 502025009883 activation loop (A-loop); other site 502025009884 transcriptional regulator MalT; Provisional; Region: PRK04841 502025009885 FHA domain; Region: FHA; pfam00498 502025009886 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 502025009887 GAF domain; Region: GAF; pfam01590 502025009888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025009889 Walker A motif; other site 502025009890 ATP binding site [chemical binding]; other site 502025009891 Walker B motif; other site 502025009892 arginine finger; other site 502025009893 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025009894 helicase 45; Provisional; Region: PTZ00424 502025009895 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 502025009896 ATP binding site [chemical binding]; other site 502025009897 Mg++ binding site [ion binding]; other site 502025009898 motif III; other site 502025009899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025009900 nucleotide binding region [chemical binding]; other site 502025009901 ATP-binding site [chemical binding]; other site 502025009902 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 502025009903 RNA binding site [nucleotide binding]; other site 502025009904 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 502025009905 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 502025009906 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 502025009907 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025009908 Ligand binding site; other site 502025009909 Putative Catalytic site; other site 502025009910 DXD motif; other site 502025009911 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 502025009912 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 502025009913 dimerization interface [polypeptide binding]; other site 502025009914 putative ATP binding site [chemical binding]; other site 502025009915 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 502025009916 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 502025009917 active site 502025009918 substrate binding site [chemical binding]; other site 502025009919 cosubstrate binding site; other site 502025009920 catalytic site [active] 502025009921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 502025009922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009923 active site 502025009924 ATP binding site [chemical binding]; other site 502025009925 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025009926 substrate binding site [chemical binding]; other site 502025009927 activation loop (A-loop); other site 502025009928 AAA ATPase domain; Region: AAA_16; pfam13191 502025009929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025009930 binding surface 502025009931 TPR motif; other site 502025009932 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025009933 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025009934 active site 502025009935 ATP binding site [chemical binding]; other site 502025009936 substrate binding site [chemical binding]; other site 502025009937 activation loop (A-loop); other site 502025009938 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 502025009939 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025009940 active site 502025009941 metal binding site [ion binding]; metal-binding site 502025009942 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025009943 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 502025009944 Cysteine-rich domain; Region: CCG; pfam02754 502025009945 Cysteine-rich domain; Region: CCG; pfam02754 502025009946 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 502025009947 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 502025009948 Catalytic site [active] 502025009949 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 502025009950 GTP-binding protein LepA; Provisional; Region: PRK05433 502025009951 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 502025009952 G1 box; other site 502025009953 putative GEF interaction site [polypeptide binding]; other site 502025009954 GTP/Mg2+ binding site [chemical binding]; other site 502025009955 Switch I region; other site 502025009956 G2 box; other site 502025009957 G3 box; other site 502025009958 Switch II region; other site 502025009959 G4 box; other site 502025009960 G5 box; other site 502025009961 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 502025009962 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 502025009963 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 502025009964 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 502025009965 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 502025009966 dimer interface [polypeptide binding]; other site 502025009967 active site 502025009968 glycine-pyridoxal phosphate binding site [chemical binding]; other site 502025009969 folate binding site [chemical binding]; other site 502025009970 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 502025009971 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 502025009972 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 502025009973 Walker A; other site 502025009974 Cupin domain; Region: Cupin_2; pfam07883 502025009975 Cupin domain; Region: Cupin_2; pfam07883 502025009976 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 502025009977 B12 binding site [chemical binding]; other site 502025009978 cobalt ligand [ion binding]; other site 502025009979 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025009980 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025009981 active site 502025009982 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025009983 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025009984 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 502025009985 FAD binding site [chemical binding]; other site 502025009986 homotetramer interface [polypeptide binding]; other site 502025009987 substrate binding pocket [chemical binding]; other site 502025009988 catalytic base [active] 502025009989 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 502025009990 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025009991 substrate binding site [chemical binding]; other site 502025009992 oxyanion hole (OAH) forming residues; other site 502025009993 trimer interface [polypeptide binding]; other site 502025009994 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 502025009995 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025009996 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025009997 putative acyltransferase; Provisional; Region: PRK05790 502025009998 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025009999 dimer interface [polypeptide binding]; other site 502025010000 active site 502025010001 MASE1; Region: MASE1; cl17823 502025010002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025010003 dimer interface [polypeptide binding]; other site 502025010004 phosphorylation site [posttranslational modification] 502025010005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025010006 ATP binding site [chemical binding]; other site 502025010007 Mg2+ binding site [ion binding]; other site 502025010008 G-X-G motif; other site 502025010009 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 502025010010 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 502025010011 putative ligand binding site [chemical binding]; other site 502025010012 NAD binding site [chemical binding]; other site 502025010013 dimerization interface [polypeptide binding]; other site 502025010014 catalytic site [active] 502025010015 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 502025010016 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025010017 FeS/SAM binding site; other site 502025010018 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 502025010019 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 502025010020 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 502025010021 catalytic triad [active] 502025010022 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 502025010023 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 502025010024 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 502025010025 putative active site [active] 502025010026 putative active site [active] 502025010027 catalytic site [active] 502025010028 catalytic site [active] 502025010029 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 502025010030 putative active site [active] 502025010031 catalytic site [active] 502025010032 Uncharacterized conserved protein [Function unknown]; Region: COG0398 502025010033 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 502025010034 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025010035 Radical SAM superfamily; Region: Radical_SAM; pfam04055 502025010036 FeS/SAM binding site; other site 502025010037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010038 TPR repeat; Region: TPR_11; pfam13414 502025010039 binding surface 502025010040 TPR motif; other site 502025010041 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010042 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010043 active site 502025010044 ATP binding site [chemical binding]; other site 502025010045 substrate binding site [chemical binding]; other site 502025010046 activation loop (A-loop); other site 502025010047 PEGA domain; Region: PEGA; pfam08308 502025010048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010049 NAD(P) binding site [chemical binding]; other site 502025010050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 502025010052 SEC-C motif; Region: SEC-C; pfam02810 502025010053 Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; Region: H2A; cl00074 502025010054 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 502025010055 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 502025010056 Beta-lactamase; Region: Beta-lactamase; cl17358 502025010057 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025010058 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025010059 active site 502025010060 metal binding site [ion binding]; metal-binding site 502025010061 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 502025010062 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 502025010063 Right handed beta helix region; Region: Beta_helix; pfam13229 502025010064 Right handed beta helix region; Region: Beta_helix; pfam13229 502025010065 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 502025010066 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 502025010067 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 502025010068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025010069 Walker A/P-loop; other site 502025010070 ATP binding site [chemical binding]; other site 502025010071 Q-loop/lid; other site 502025010072 ABC transporter signature motif; other site 502025010073 Walker B; other site 502025010074 D-loop; other site 502025010075 H-loop/switch region; other site 502025010076 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 502025010077 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 502025010078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025010079 Walker A/P-loop; other site 502025010080 ATP binding site [chemical binding]; other site 502025010081 Q-loop/lid; other site 502025010082 ABC transporter signature motif; other site 502025010083 Walker B; other site 502025010084 D-loop; other site 502025010085 H-loop/switch region; other site 502025010086 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025010087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025010088 putative active site [active] 502025010089 heme pocket [chemical binding]; other site 502025010090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025010091 dimer interface [polypeptide binding]; other site 502025010092 phosphorylation site [posttranslational modification] 502025010093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025010094 ATP binding site [chemical binding]; other site 502025010095 Mg2+ binding site [ion binding]; other site 502025010096 G-X-G motif; other site 502025010097 Response regulator receiver domain; Region: Response_reg; pfam00072 502025010098 Response regulator receiver domain; Region: Response_reg; pfam00072 502025010099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025010100 active site 502025010101 phosphorylation site [posttranslational modification] 502025010102 intermolecular recognition site; other site 502025010103 dimerization interface [polypeptide binding]; other site 502025010104 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025010105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025010106 metal binding site [ion binding]; metal-binding site 502025010107 active site 502025010108 I-site; other site 502025010109 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025010110 putative active site [active] 502025010111 putative metal binding site [ion binding]; other site 502025010112 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025010113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010114 TPR motif; other site 502025010115 binding surface 502025010116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010117 TPR motif; other site 502025010118 binding surface 502025010119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010120 TPR motif; other site 502025010121 binding surface 502025010122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010123 TPR motif; other site 502025010124 binding surface 502025010125 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 502025010126 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 502025010127 catalytic core [active] 502025010128 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025010129 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 502025010130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010131 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010132 active site 502025010133 ATP binding site [chemical binding]; other site 502025010134 substrate binding site [chemical binding]; other site 502025010135 activation loop (A-loop); other site 502025010136 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010137 AAA ATPase domain; Region: AAA_16; pfam13191 502025010138 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025010139 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025010140 structural tetrad; other site 502025010141 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025010142 structural tetrad; other site 502025010143 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 502025010144 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025010145 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025010146 phosphopeptide binding site; other site 502025010147 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010148 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010149 active site 502025010150 ATP binding site [chemical binding]; other site 502025010151 substrate binding site [chemical binding]; other site 502025010152 activation loop (A-loop); other site 502025010153 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010154 AAA ATPase domain; Region: AAA_16; pfam13191 502025010155 TPR repeat; Region: TPR_11; pfam13414 502025010156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010157 binding surface 502025010158 TPR motif; other site 502025010159 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025010160 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025010161 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 502025010162 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025010163 Thioredoxin; Region: Thioredoxin_4; cl17273 502025010164 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025010165 Protein phosphatase 2C; Region: PP2C; pfam00481 502025010166 active site 502025010167 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025010168 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025010169 ligand binding site [chemical binding]; other site 502025010170 flexible hinge region; other site 502025010171 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 502025010172 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 502025010173 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 502025010174 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 502025010175 Helix-turn-helix domain; Region: HTH_18; pfam12833 502025010176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025010177 Uncharacterized conserved protein [Function unknown]; Region: COG3461 502025010178 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 502025010179 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 502025010180 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 502025010181 Ligand Binding Site [chemical binding]; other site 502025010182 Molecular Tunnel; other site 502025010183 colanic acid exporter; Provisional; Region: PRK10459 502025010184 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 502025010185 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 502025010186 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 502025010187 dimerization interface [polypeptide binding]; other site 502025010188 ATP binding site [chemical binding]; other site 502025010189 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 502025010190 dimerization interface [polypeptide binding]; other site 502025010191 ATP binding site [chemical binding]; other site 502025010192 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 502025010193 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 502025010194 putative active site [active] 502025010195 catalytic triad [active] 502025010196 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 502025010197 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 502025010198 active site 502025010199 ATP binding site [chemical binding]; other site 502025010200 substrate binding site [chemical binding]; other site 502025010201 adenylosuccinate lyase; Provisional; Region: PRK07492 502025010202 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 502025010203 tetramer interface [polypeptide binding]; other site 502025010204 active site 502025010205 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 502025010206 trimer interface [polypeptide binding]; other site 502025010207 active site 502025010208 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 502025010209 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 502025010210 RNase E interface [polypeptide binding]; other site 502025010211 trimer interface [polypeptide binding]; other site 502025010212 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 502025010213 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 502025010214 RNase E interface [polypeptide binding]; other site 502025010215 trimer interface [polypeptide binding]; other site 502025010216 active site 502025010217 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 502025010218 putative nucleic acid binding region [nucleotide binding]; other site 502025010219 G-X-X-G motif; other site 502025010220 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 502025010221 RNA binding site [nucleotide binding]; other site 502025010222 domain interface; other site 502025010223 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 502025010224 16S/18S rRNA binding site [nucleotide binding]; other site 502025010225 S13e-L30e interaction site [polypeptide binding]; other site 502025010226 25S rRNA binding site [nucleotide binding]; other site 502025010227 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 502025010228 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 502025010229 RNA binding site [nucleotide binding]; other site 502025010230 active site 502025010231 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 502025010232 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 502025010233 Protein of unknown function (DUF503); Region: DUF503; pfam04456 502025010234 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 502025010235 translation initiation factor IF-2; Region: IF-2; TIGR00487 502025010236 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 502025010237 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 502025010238 G1 box; other site 502025010239 putative GEF interaction site [polypeptide binding]; other site 502025010240 GTP/Mg2+ binding site [chemical binding]; other site 502025010241 Switch I region; other site 502025010242 G2 box; other site 502025010243 G3 box; other site 502025010244 Switch II region; other site 502025010245 G4 box; other site 502025010246 G5 box; other site 502025010247 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 502025010248 Translation-initiation factor 2; Region: IF-2; pfam11987 502025010249 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 502025010250 Protein of unknown function (DUF448); Region: DUF448; pfam04296 502025010251 putative RNA binding cleft [nucleotide binding]; other site 502025010252 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 502025010253 NusA N-terminal domain; Region: NusA_N; pfam08529 502025010254 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 502025010255 RNA binding site [nucleotide binding]; other site 502025010256 homodimer interface [polypeptide binding]; other site 502025010257 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 502025010258 G-X-X-G motif; other site 502025010259 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 502025010260 G-X-X-G motif; other site 502025010261 Sm and related proteins; Region: Sm_like; cl00259 502025010262 ribosome maturation protein RimP; Reviewed; Region: PRK00092 502025010263 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 502025010264 putative oligomer interface [polypeptide binding]; other site 502025010265 putative RNA binding site [nucleotide binding]; other site 502025010266 nitrilase; Region: PLN02798 502025010267 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 502025010268 putative active site [active] 502025010269 catalytic triad [active] 502025010270 dimer interface [polypeptide binding]; other site 502025010271 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 502025010272 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 502025010273 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 502025010274 AAA domain; Region: AAA_23; pfam13476 502025010275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025010276 Walker A/P-loop; other site 502025010277 ATP binding site [chemical binding]; other site 502025010278 AAA domain; Region: AAA_21; pfam13304 502025010279 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 502025010280 active site 502025010281 dimer interface [polypeptide binding]; other site 502025010282 prolyl-tRNA synthetase; Provisional; Region: PRK09194 502025010283 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 502025010284 dimer interface [polypeptide binding]; other site 502025010285 motif 1; other site 502025010286 active site 502025010287 motif 2; other site 502025010288 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 502025010289 putative deacylase active site [active] 502025010290 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 502025010291 active site 502025010292 motif 3; other site 502025010293 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 502025010294 anticodon binding site; other site 502025010295 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 502025010296 TPR repeat; Region: TPR_11; pfam13414 502025010297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010298 binding surface 502025010299 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 502025010300 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 502025010301 active site 502025010302 Imelysin; Region: Peptidase_M75; cl09159 502025010303 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025010304 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 502025010305 Imelysin; Region: Peptidase_M75; pfam09375 502025010306 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 502025010307 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 502025010308 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 502025010309 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 502025010310 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 502025010311 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010312 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010313 active site 502025010314 ATP binding site [chemical binding]; other site 502025010315 substrate binding site [chemical binding]; other site 502025010316 activation loop (A-loop); other site 502025010317 PEGA domain; Region: PEGA; pfam08308 502025010318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010319 TPR motif; other site 502025010320 TPR repeat; Region: TPR_11; pfam13414 502025010321 binding surface 502025010322 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010323 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010324 active site 502025010325 ATP binding site [chemical binding]; other site 502025010326 substrate binding site [chemical binding]; other site 502025010327 activation loop (A-loop); other site 502025010328 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 502025010329 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 502025010330 TPP-binding site [chemical binding]; other site 502025010331 dimer interface [polypeptide binding]; other site 502025010332 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 502025010333 PYR/PP interface [polypeptide binding]; other site 502025010334 dimer interface [polypeptide binding]; other site 502025010335 TPP binding site [chemical binding]; other site 502025010336 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 502025010337 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010338 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010339 active site 502025010340 ATP binding site [chemical binding]; other site 502025010341 substrate binding site [chemical binding]; other site 502025010342 activation loop (A-loop); other site 502025010343 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025010344 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010345 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010346 active site 502025010347 ATP binding site [chemical binding]; other site 502025010348 substrate binding site [chemical binding]; other site 502025010349 activation loop (A-loop); other site 502025010350 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010351 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010352 active site 502025010353 ATP binding site [chemical binding]; other site 502025010354 substrate binding site [chemical binding]; other site 502025010355 activation loop (A-loop); other site 502025010356 Uncharacterized conserved protein [Function unknown]; Region: COG3287 502025010357 FIST N domain; Region: FIST; pfam08495 502025010358 FIST C domain; Region: FIST_C; pfam10442 502025010359 FIST N domain; Region: FIST; pfam08495 502025010360 FIST N domain; Region: FIST; pfam08495 502025010361 Uncharacterized conserved protein [Function unknown]; Region: COG3287 502025010362 FIST C domain; Region: FIST_C; pfam10442 502025010363 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025010364 protein binding site [polypeptide binding]; other site 502025010365 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 502025010366 Protein of unknown function, DUF482; Region: DUF482; pfam04339 502025010367 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 502025010368 putative GSH binding site [chemical binding]; other site 502025010369 catalytic residues [active] 502025010370 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 502025010371 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025010372 active site residue [active] 502025010373 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025010374 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 502025010375 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 502025010376 acyl-activating enzyme (AAE) consensus motif; other site 502025010377 putative AMP binding site [chemical binding]; other site 502025010378 putative active site [active] 502025010379 putative CoA binding site [chemical binding]; other site 502025010380 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 502025010381 IHF dimer interface [polypeptide binding]; other site 502025010382 IHF - DNA interface [nucleotide binding]; other site 502025010383 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 502025010384 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 502025010385 Qi binding site; other site 502025010386 intrachain domain interface; other site 502025010387 interchain domain interface [polypeptide binding]; other site 502025010388 heme bH binding site [chemical binding]; other site 502025010389 heme bL binding site [chemical binding]; other site 502025010390 Qo binding site; other site 502025010391 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 502025010392 Cytochrome c; Region: Cytochrom_C; pfam00034 502025010393 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 502025010394 iron-sulfur cluster [ion binding]; other site 502025010395 [2Fe-2S] cluster binding site [ion binding]; other site 502025010396 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 502025010397 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 502025010398 TAP-like protein; Region: Abhydrolase_4; pfam08386 502025010399 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025010400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010401 binding surface 502025010402 TPR motif; other site 502025010403 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 502025010404 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 502025010405 active sites [active] 502025010406 tetramer interface [polypeptide binding]; other site 502025010407 imidazolonepropionase; Validated; Region: PRK09356 502025010408 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 502025010409 active site 502025010410 P-loop containing region of AAA domain; Region: AAA_29; cl17516 502025010411 AAA domain; Region: AAA_23; pfam13476 502025010412 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 502025010413 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 502025010414 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 502025010415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025010416 Walker A motif; other site 502025010417 ATP binding site [chemical binding]; other site 502025010418 Walker B motif; other site 502025010419 arginine finger; other site 502025010420 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 502025010421 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 502025010422 RuvA N terminal domain; Region: RuvA_N; pfam01330 502025010423 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 502025010424 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 502025010425 active site 502025010426 putative DNA-binding cleft [nucleotide binding]; other site 502025010427 dimer interface [polypeptide binding]; other site 502025010428 hypothetical protein; Validated; Region: PRK00110 502025010429 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 502025010430 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025010431 catalytic residue [active] 502025010432 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 502025010433 active site 502025010434 dimer interface [polypeptide binding]; other site 502025010435 FOG: PKD repeat [General function prediction only]; Region: COG3291 502025010436 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 502025010437 Periplasmic binding protein TroA_c. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145 502025010438 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 502025010439 putative ligand binding site [chemical binding]; other site 502025010440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025010441 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 502025010442 Walker A/P-loop; other site 502025010443 ATP binding site [chemical binding]; other site 502025010444 Q-loop/lid; other site 502025010445 ABC transporter signature motif; other site 502025010446 Walker B; other site 502025010447 D-loop; other site 502025010448 H-loop/switch region; other site 502025010449 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 502025010450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 502025010451 ABC-ATPase subunit interface; other site 502025010452 dimer interface [polypeptide binding]; other site 502025010453 putative PBP binding regions; other site 502025010454 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 502025010455 glycine dehydrogenase; Provisional; Region: PRK05367 502025010456 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 502025010457 tetramer interface [polypeptide binding]; other site 502025010458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025010459 catalytic residue [active] 502025010460 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 502025010461 tetramer interface [polypeptide binding]; other site 502025010462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025010463 catalytic residue [active] 502025010464 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 502025010465 dimer interface [polypeptide binding]; other site 502025010466 allosteric magnesium binding site [ion binding]; other site 502025010467 active site 502025010468 aspartate-rich active site metal binding site; other site 502025010469 Schiff base residues; other site 502025010470 hypothetical protein; Validated; Region: PRK09039 502025010471 hypothetical protein; Validated; Region: PRK09039 502025010472 Leucine rich repeat; Region: LRR_8; pfam13855 502025010473 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025010474 putative catalytic site [active] 502025010475 putative metal binding site [ion binding]; other site 502025010476 putative phosphate binding site [ion binding]; other site 502025010477 Esterase/lipase [General function prediction only]; Region: COG1647 502025010478 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025010479 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 502025010480 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 502025010481 minor groove reading motif; other site 502025010482 helix-hairpin-helix signature motif; other site 502025010483 substrate binding pocket [chemical binding]; other site 502025010484 active site 502025010485 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 502025010486 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025010487 nudix motif; other site 502025010488 Isochorismatase family; Region: Isochorismatase; pfam00857 502025010489 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 502025010490 catalytic triad [active] 502025010491 conserved cis-peptide bond; other site 502025010492 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 502025010493 homotrimer interaction site [polypeptide binding]; other site 502025010494 putative active site [active] 502025010495 pyrimidine utilization protein A; Region: RutA; TIGR03612 502025010496 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 502025010497 active site 502025010498 dimer interface [polypeptide binding]; other site 502025010499 non-prolyl cis peptide bond; other site 502025010500 insertion regions; other site 502025010501 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 502025010502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025010503 FeS/SAM binding site; other site 502025010504 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 502025010505 epoxyqueuosine reductase; Region: TIGR00276 502025010506 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 502025010507 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025010508 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 502025010509 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 502025010510 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 502025010511 putative NAD(P) binding site [chemical binding]; other site 502025010512 catalytic Zn binding site [ion binding]; other site 502025010513 structural Zn binding site [ion binding]; other site 502025010514 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010515 active site 502025010516 ATP binding site [chemical binding]; other site 502025010517 substrate binding site [chemical binding]; other site 502025010518 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 502025010519 activation loop (A-loop); other site 502025010520 cyclase homology domain; Region: CHD; cd07302 502025010521 nucleotidyl binding site; other site 502025010522 metal binding site [ion binding]; metal-binding site 502025010523 dimer interface [polypeptide binding]; other site 502025010524 AAA ATPase domain; Region: AAA_16; pfam13191 502025010525 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 502025010526 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 502025010527 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 502025010528 catalytic site [active] 502025010529 subunit interface [polypeptide binding]; other site 502025010530 dihydroorotase; Validated; Region: pyrC; PRK09357 502025010531 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025010532 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 502025010533 active site 502025010534 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 502025010535 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 502025010536 putative MPT binding site; other site 502025010537 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025010538 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025010539 catalytic loop [active] 502025010540 iron binding site [ion binding]; other site 502025010541 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025010542 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025010543 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025010544 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025010545 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025010546 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025010547 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025010548 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025010549 phosphopeptide binding site; other site 502025010550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025010551 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025010552 Walker A motif; other site 502025010553 ATP binding site [chemical binding]; other site 502025010554 Walker B motif; other site 502025010555 arginine finger; other site 502025010556 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 502025010557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010558 binding surface 502025010559 TPR motif; other site 502025010560 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025010561 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025010562 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 502025010563 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025010564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010565 TPR motif; other site 502025010566 binding surface 502025010567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010568 binding surface 502025010569 TPR motif; other site 502025010570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025010571 binding surface 502025010572 TPR motif; other site 502025010573 TPR repeat; Region: TPR_11; pfam13414 502025010574 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 502025010575 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 502025010576 periplasmic chaperone; Provisional; Region: PRK10780 502025010577 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 502025010578 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 502025010579 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 502025010580 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 502025010581 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 502025010582 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 502025010583 Surface antigen; Region: Bac_surface_Ag; pfam01103 502025010584 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025010585 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 502025010586 Walker A/P-loop; other site 502025010587 ATP binding site [chemical binding]; other site 502025010588 Q-loop/lid; other site 502025010589 ABC transporter signature motif; other site 502025010590 Walker B; other site 502025010591 D-loop; other site 502025010592 H-loop/switch region; other site 502025010593 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025010594 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 502025010595 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025010596 FtsX-like permease family; Region: FtsX; pfam02687 502025010597 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 502025010598 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 502025010599 dimer interface [polypeptide binding]; other site 502025010600 putative anticodon binding site; other site 502025010601 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 502025010602 motif 1; other site 502025010603 active site 502025010604 motif 2; other site 502025010605 motif 3; other site 502025010606 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 502025010607 catalytic residues [active] 502025010608 Creatinine amidohydrolase; Region: Creatininase; pfam02633 502025010609 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 502025010610 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 502025010611 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 502025010612 alphaNTD homodimer interface [polypeptide binding]; other site 502025010613 alphaNTD - beta interaction site [polypeptide binding]; other site 502025010614 alphaNTD - beta' interaction site [polypeptide binding]; other site 502025010615 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 502025010616 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 502025010617 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 502025010618 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025010619 RNA binding surface [nucleotide binding]; other site 502025010620 30S ribosomal protein S11; Validated; Region: PRK05309 502025010621 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 502025010622 30S ribosomal protein S13; Region: bact_S13; TIGR03631 502025010623 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 502025010624 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 502025010625 active site 502025010626 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 502025010627 SecY translocase; Region: SecY; pfam00344 502025010628 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 502025010629 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 502025010630 23S rRNA binding site [nucleotide binding]; other site 502025010631 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 502025010632 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 502025010633 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 502025010634 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 502025010635 5S rRNA interface [nucleotide binding]; other site 502025010636 23S rRNA interface [nucleotide binding]; other site 502025010637 L5 interface [polypeptide binding]; other site 502025010638 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 502025010639 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 502025010640 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 502025010641 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 502025010642 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 502025010643 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 502025010644 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 502025010645 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 502025010646 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 502025010647 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 502025010648 RNA binding site [nucleotide binding]; other site 502025010649 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 502025010650 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 502025010651 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 502025010652 putative translocon interaction site; other site 502025010653 signal recognition particle (SRP54) interaction site; other site 502025010654 L23 interface [polypeptide binding]; other site 502025010655 trigger factor interaction site; other site 502025010656 23S rRNA interface [nucleotide binding]; other site 502025010657 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 502025010658 23S rRNA interface [nucleotide binding]; other site 502025010659 5S rRNA interface [nucleotide binding]; other site 502025010660 putative antibiotic binding site [chemical binding]; other site 502025010661 L25 interface [polypeptide binding]; other site 502025010662 L27 interface [polypeptide binding]; other site 502025010663 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 502025010664 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 502025010665 G-X-X-G motif; other site 502025010666 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 502025010667 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 502025010668 putative translocon binding site; other site 502025010669 protein-rRNA interface [nucleotide binding]; other site 502025010670 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 502025010671 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 502025010672 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 502025010673 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 502025010674 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 502025010675 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 502025010676 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 502025010677 elongation factor Tu; Reviewed; Region: PRK00049 502025010678 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 502025010679 G1 box; other site 502025010680 GEF interaction site [polypeptide binding]; other site 502025010681 GTP/Mg2+ binding site [chemical binding]; other site 502025010682 Switch I region; other site 502025010683 G2 box; other site 502025010684 G3 box; other site 502025010685 Switch II region; other site 502025010686 G4 box; other site 502025010687 G5 box; other site 502025010688 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 502025010689 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 502025010690 Antibiotic Binding Site [chemical binding]; other site 502025010691 30S ribosomal protein S7; Validated; Region: PRK05302 502025010692 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 502025010693 S17 interaction site [polypeptide binding]; other site 502025010694 S8 interaction site; other site 502025010695 16S rRNA interaction site [nucleotide binding]; other site 502025010696 streptomycin interaction site [chemical binding]; other site 502025010697 23S rRNA interaction site [nucleotide binding]; other site 502025010698 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 502025010699 PEGA domain; Region: PEGA; pfam08308 502025010700 PEGA domain; Region: PEGA; pfam08308 502025010701 Family description; Region: VCBS; pfam13517 502025010702 Family description; Region: VCBS; pfam13517 502025010703 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010704 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010705 active site 502025010706 ATP binding site [chemical binding]; other site 502025010707 substrate binding site [chemical binding]; other site 502025010708 activation loop (A-loop); other site 502025010709 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025010710 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 502025010711 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 502025010712 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025010713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025010714 NAD(P) binding site [chemical binding]; other site 502025010715 active site 502025010716 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 502025010717 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 502025010718 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 502025010719 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 502025010720 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 502025010721 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 502025010722 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 502025010723 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 502025010724 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 502025010725 DNA binding site [nucleotide binding] 502025010726 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 502025010727 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 502025010728 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 502025010729 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 502025010730 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 502025010731 RPB11 interaction site [polypeptide binding]; other site 502025010732 RPB12 interaction site [polypeptide binding]; other site 502025010733 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 502025010734 RPB3 interaction site [polypeptide binding]; other site 502025010735 RPB1 interaction site [polypeptide binding]; other site 502025010736 RPB11 interaction site [polypeptide binding]; other site 502025010737 RPB10 interaction site [polypeptide binding]; other site 502025010738 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 502025010739 peripheral dimer interface [polypeptide binding]; other site 502025010740 core dimer interface [polypeptide binding]; other site 502025010741 L10 interface [polypeptide binding]; other site 502025010742 L11 interface [polypeptide binding]; other site 502025010743 putative EF-Tu interaction site [polypeptide binding]; other site 502025010744 putative EF-G interaction site [polypeptide binding]; other site 502025010745 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 502025010746 23S rRNA interface [nucleotide binding]; other site 502025010747 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 502025010748 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 502025010749 mRNA/rRNA interface [nucleotide binding]; other site 502025010750 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 502025010751 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 502025010752 putative homodimer interface [polypeptide binding]; other site 502025010753 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 502025010754 heterodimer interface [polypeptide binding]; other site 502025010755 homodimer interface [polypeptide binding]; other site 502025010756 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 502025010757 elongation factor Tu; Reviewed; Region: PRK00049 502025010758 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 502025010759 G1 box; other site 502025010760 GEF interaction site [polypeptide binding]; other site 502025010761 GTP/Mg2+ binding site [chemical binding]; other site 502025010762 Switch I region; other site 502025010763 G2 box; other site 502025010764 G3 box; other site 502025010765 Switch II region; other site 502025010766 G4 box; other site 502025010767 G5 box; other site 502025010768 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 502025010769 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 502025010770 Antibiotic Binding Site [chemical binding]; other site 502025010771 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 502025010772 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 502025010773 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 502025010774 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025010775 NAD(P) binding site [chemical binding]; other site 502025010776 catalytic residues [active] 502025010777 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 502025010778 23S rRNA interface [nucleotide binding]; other site 502025010779 L3 interface [polypeptide binding]; other site 502025010780 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 502025010781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025010782 dimer interface [polypeptide binding]; other site 502025010783 phosphorylation site [posttranslational modification] 502025010784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025010785 ATP binding site [chemical binding]; other site 502025010786 Mg2+ binding site [ion binding]; other site 502025010787 G-X-G motif; other site 502025010788 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025010789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025010790 active site 502025010791 phosphorylation site [posttranslational modification] 502025010792 intermolecular recognition site; other site 502025010793 dimerization interface [polypeptide binding]; other site 502025010794 Response regulator receiver domain; Region: Response_reg; pfam00072 502025010795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025010796 active site 502025010797 phosphorylation site [posttranslational modification] 502025010798 intermolecular recognition site; other site 502025010799 dimerization interface [polypeptide binding]; other site 502025010800 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 502025010801 Sulfatase; Region: Sulfatase; pfam00884 502025010802 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025010803 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 502025010804 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025010805 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025010806 ligand binding site [chemical binding]; other site 502025010807 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 502025010808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025010809 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 502025010810 ApbE family; Region: ApbE; pfam02424 502025010811 HAMP domain; Region: HAMP; pfam00672 502025010812 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 502025010813 TrkA-N domain; Region: TrkA_N; pfam02254 502025010814 TrkA-C domain; Region: TrkA_C; pfam02080 502025010815 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 502025010816 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 502025010817 putative phosphate acyltransferase; Provisional; Region: PRK05331 502025010818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 502025010819 active site 502025010820 motif I; other site 502025010821 motif II; other site 502025010822 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025010823 active site 502025010824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025010825 S-adenosylmethionine binding site [chemical binding]; other site 502025010826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025010827 ATP binding site [chemical binding]; other site 502025010828 Mg2+ binding site [ion binding]; other site 502025010829 G-X-G motif; other site 502025010830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025010831 ATP binding site [chemical binding]; other site 502025010832 Mg2+ binding site [ion binding]; other site 502025010833 G-X-G motif; other site 502025010834 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 502025010835 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 502025010836 active site 502025010837 Zn binding site [ion binding]; other site 502025010838 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 502025010839 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 502025010840 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 502025010841 Response regulator receiver domain; Region: Response_reg; pfam00072 502025010842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025010843 active site 502025010844 phosphorylation site [posttranslational modification] 502025010845 intermolecular recognition site; other site 502025010846 dimerization interface [polypeptide binding]; other site 502025010847 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025010848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025010849 metal binding site [ion binding]; metal-binding site 502025010850 active site 502025010851 I-site; other site 502025010852 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 502025010853 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010854 active site 502025010855 ATP binding site [chemical binding]; other site 502025010856 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010857 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010858 substrate binding site [chemical binding]; other site 502025010859 activation loop (A-loop); other site 502025010860 AAA ATPase domain; Region: AAA_16; pfam13191 502025010861 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 502025010862 PEGA domain; Region: PEGA; pfam08308 502025010863 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010864 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010865 active site 502025010866 ATP binding site [chemical binding]; other site 502025010867 substrate binding site [chemical binding]; other site 502025010868 activation loop (A-loop); other site 502025010869 Predicted ATPase [General function prediction only]; Region: COG3899 502025010870 AAA ATPase domain; Region: AAA_16; pfam13191 502025010871 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010872 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010873 active site 502025010874 ATP binding site [chemical binding]; other site 502025010875 substrate binding site [chemical binding]; other site 502025010876 activation loop (A-loop); other site 502025010877 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 502025010878 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 502025010879 active site 502025010880 PHP Thumb interface [polypeptide binding]; other site 502025010881 metal binding site [ion binding]; metal-binding site 502025010882 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 502025010883 generic binding surface I; other site 502025010884 generic binding surface II; other site 502025010885 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 502025010886 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 502025010887 active site pocket [active] 502025010888 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 502025010889 tyrosine decarboxylase; Region: PLN02880 502025010890 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025010891 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025010892 catalytic residue [active] 502025010893 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 502025010894 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 502025010895 NAD binding site [chemical binding]; other site 502025010896 ligand binding site [chemical binding]; other site 502025010897 catalytic site [active] 502025010898 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 502025010899 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025010900 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 502025010901 NAD(P) binding pocket [chemical binding]; other site 502025010902 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025010903 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025010904 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025010905 ligand binding site [chemical binding]; other site 502025010906 flexible hinge region; other site 502025010907 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010908 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010909 active site 502025010910 ATP binding site [chemical binding]; other site 502025010911 substrate binding site [chemical binding]; other site 502025010912 activation loop (A-loop); other site 502025010913 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 502025010914 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025010915 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025010916 active site 502025010917 ATP binding site [chemical binding]; other site 502025010918 substrate binding site [chemical binding]; other site 502025010919 activation loop (A-loop); other site 502025010920 AAA ATPase domain; Region: AAA_16; pfam13191 502025010921 Adenosylhomocysteinase; Provisional; Region: PTZ00075 502025010922 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 502025010923 homotetramer interface [polypeptide binding]; other site 502025010924 ligand binding site [chemical binding]; other site 502025010925 catalytic site [active] 502025010926 NAD binding site [chemical binding]; other site 502025010927 Pectinacetylesterase; Region: PAE; pfam03283 502025010928 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 502025010929 putative active site [active] 502025010930 catalytic site [active] 502025010931 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 502025010932 PLD-like domain; Region: PLDc_2; pfam13091 502025010933 putative active site [active] 502025010934 catalytic site [active] 502025010935 translocation protein TolB; Provisional; Region: tolB; PRK01029 502025010936 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 502025010937 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 502025010938 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 502025010939 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025010940 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025010941 ligand binding site [chemical binding]; other site 502025010942 flexible hinge region; other site 502025010943 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 502025010944 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 502025010945 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 502025010946 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 502025010947 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025010948 metal ion-dependent adhesion site (MIDAS); other site 502025010949 Predicted ATPase [General function prediction only]; Region: COG4637 502025010950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025010951 Walker A/P-loop; other site 502025010952 ATP binding site [chemical binding]; other site 502025010953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025010954 ABC transporter signature motif; other site 502025010955 Walker B; other site 502025010956 D-loop; other site 502025010957 H-loop/switch region; other site 502025010958 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025010959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025010960 glycogen branching enzyme; Provisional; Region: PRK12313 502025010961 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 502025010962 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 502025010963 active site 502025010964 catalytic site [active] 502025010965 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 502025010966 trehalose synthase; Region: treS_nterm; TIGR02456 502025010967 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 502025010968 active site 502025010969 catalytic site [active] 502025010970 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 502025010971 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 502025010972 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 502025010973 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 502025010974 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 502025010975 active site 502025010976 homodimer interface [polypeptide binding]; other site 502025010977 catalytic site [active] 502025010978 acceptor binding site [chemical binding]; other site 502025010979 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 502025010980 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025010981 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 502025010982 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010983 active site 502025010984 ATP binding site [chemical binding]; other site 502025010985 substrate binding site [chemical binding]; other site 502025010986 activation loop (A-loop); other site 502025010987 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025010988 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025010989 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 502025010990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 502025010991 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025010992 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025010993 ligand binding site [chemical binding]; other site 502025010994 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 502025010995 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025010996 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025010997 ligand binding site [chemical binding]; other site 502025010998 flexible hinge region; other site 502025010999 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 502025011000 putative switch regulator; other site 502025011001 non-specific DNA interactions [nucleotide binding]; other site 502025011002 DNA binding site [nucleotide binding] 502025011003 sequence specific DNA binding site [nucleotide binding]; other site 502025011004 putative cAMP binding site [chemical binding]; other site 502025011005 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 502025011006 thiS-thiF/thiG interaction site; other site 502025011007 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 502025011008 ThiS interaction site; other site 502025011009 putative active site [active] 502025011010 tetramer interface [polypeptide binding]; other site 502025011011 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 502025011012 active site 502025011013 pyrophosphate binding site [ion binding]; other site 502025011014 thiamine phosphate binding site [chemical binding]; other site 502025011015 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 502025011016 SnoaL-like domain; Region: SnoaL_3; pfam13474 502025011017 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 502025011018 active site 502025011019 oxyanion hole [active] 502025011020 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 502025011021 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 502025011022 putative active site [active] 502025011023 catalytic triad [active] 502025011024 putative dimer interface [polypeptide binding]; other site 502025011025 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025011026 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 502025011027 elongation factor G; Reviewed; Region: PRK12740 502025011028 G1 box; other site 502025011029 putative GEF interaction site [polypeptide binding]; other site 502025011030 GTP/Mg2+ binding site [chemical binding]; other site 502025011031 Switch I region; other site 502025011032 G2 box; other site 502025011033 G3 box; other site 502025011034 Switch II region; other site 502025011035 G4 box; other site 502025011036 G5 box; other site 502025011037 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 502025011038 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 502025011039 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 502025011040 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 502025011041 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 502025011042 Tetramer interface [polypeptide binding]; other site 502025011043 active site 502025011044 FMN-binding site [chemical binding]; other site 502025011045 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 502025011046 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025011047 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011048 active site 502025011049 ATP binding site [chemical binding]; other site 502025011050 substrate binding site [chemical binding]; other site 502025011051 activation loop (A-loop); other site 502025011052 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 502025011053 iron-sulfur cluster [ion binding]; other site 502025011054 [2Fe-2S] cluster binding site [ion binding]; other site 502025011055 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025011056 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 502025011057 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 502025011058 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 502025011059 Electron transfer flavoprotein domain; Region: ETF; pfam01012 502025011060 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 502025011061 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 502025011062 PGAP1-like protein; Region: PGAP1; pfam07819 502025011063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011064 active site 502025011065 ATP binding site [chemical binding]; other site 502025011066 substrate binding site [chemical binding]; other site 502025011067 activation loop (A-loop); other site 502025011068 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025011069 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025011070 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025011071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 502025011072 Smr domain; Region: Smr; pfam01713 502025011073 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 502025011074 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 502025011075 tetramer interface [polypeptide binding]; other site 502025011076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011077 catalytic residue [active] 502025011078 ABC-2 type transporter; Region: ABC2_membrane; cl17235 502025011079 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 502025011080 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025011081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025011082 Walker A/P-loop; other site 502025011083 ATP binding site [chemical binding]; other site 502025011084 Q-loop/lid; other site 502025011085 ABC transporter signature motif; other site 502025011086 Walker B; other site 502025011087 D-loop; other site 502025011088 H-loop/switch region; other site 502025011089 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011090 active site 502025011091 ATP binding site [chemical binding]; other site 502025011092 substrate binding site [chemical binding]; other site 502025011093 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 502025011094 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025011095 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025011096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025011097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025011098 DNA binding residues [nucleotide binding] 502025011099 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 502025011100 Beta-lactamase; Region: Beta-lactamase; pfam00144 502025011101 D-aminopeptidase; Reviewed; Region: PRK13128 502025011102 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 502025011103 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 502025011104 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 502025011105 CoenzymeA binding site [chemical binding]; other site 502025011106 subunit interaction site [polypeptide binding]; other site 502025011107 PHB binding site; other site 502025011108 trehalose synthase; Region: treS_nterm; TIGR02456 502025011109 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 502025011110 Ca binding site [ion binding]; other site 502025011111 active site 502025011112 catalytic site [active] 502025011113 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 502025011114 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 502025011115 intersubunit interface [polypeptide binding]; other site 502025011116 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 502025011117 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 502025011118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011119 TPR motif; other site 502025011120 binding surface 502025011121 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025011122 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025011123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011124 binding surface 502025011125 TPR motif; other site 502025011126 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 502025011127 active site 502025011128 zinc binding site [ion binding]; other site 502025011129 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025011130 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025011131 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025011132 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 502025011133 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 502025011134 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025011135 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025011136 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025011137 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 502025011138 Na2 binding site [ion binding]; other site 502025011139 putative substrate binding site 1 [chemical binding]; other site 502025011140 Na binding site 1 [ion binding]; other site 502025011141 putative substrate binding site 2 [chemical binding]; other site 502025011142 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 502025011143 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 502025011144 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 502025011145 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 502025011146 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 502025011147 Double zinc ribbon; Region: DZR; pfam12773 502025011148 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025011149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025011150 S-adenosylmethionine binding site [chemical binding]; other site 502025011151 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025011152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011153 active site 502025011154 phosphorylation site [posttranslational modification] 502025011155 intermolecular recognition site; other site 502025011156 dimerization interface [polypeptide binding]; other site 502025011157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025011158 Walker A motif; other site 502025011159 ATP binding site [chemical binding]; other site 502025011160 Walker B motif; other site 502025011161 arginine finger; other site 502025011162 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025011163 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 502025011164 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 502025011165 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 502025011166 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 502025011167 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 502025011168 Restriction endonuclease; Region: Mrr_cat; pfam04471 502025011169 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 502025011170 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 502025011171 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025011172 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 502025011173 Transglycosylase; Region: Transgly; pfam00912 502025011174 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025011175 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 502025011176 active site 502025011177 metal binding site [ion binding]; metal-binding site 502025011178 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 502025011179 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025011180 putative catalytic site [active] 502025011181 putative metal binding site [ion binding]; other site 502025011182 putative phosphate binding site [ion binding]; other site 502025011183 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 502025011184 Putative zinc-finger; Region: zf-HC2; pfam13490 502025011185 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 502025011186 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025011187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025011188 DNA binding residues [nucleotide binding] 502025011189 Sulfatase; Region: Sulfatase; cl17466 502025011190 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025011191 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 502025011192 AMMECR1; Region: AMMECR1; pfam01871 502025011193 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 502025011194 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 502025011195 motif 1; other site 502025011196 dimer interface [polypeptide binding]; other site 502025011197 active site 502025011198 motif 2; other site 502025011199 motif 3; other site 502025011200 elongation factor P; Validated; Region: PRK00529 502025011201 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 502025011202 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 502025011203 RNA binding site [nucleotide binding]; other site 502025011204 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 502025011205 RNA binding site [nucleotide binding]; other site 502025011206 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011207 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025011208 phosphopeptide binding site; other site 502025011209 Predicted transcriptional regulator [Transcription]; Region: COG1959 502025011210 Transcriptional regulator; Region: Rrf2; pfam02082 502025011211 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 502025011212 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025011213 dimer interface [polypeptide binding]; other site 502025011214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011215 catalytic residue [active] 502025011216 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 502025011217 ATP binding site [chemical binding]; other site 502025011218 substrate interface [chemical binding]; other site 502025011219 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 502025011220 MoaE interaction surface [polypeptide binding]; other site 502025011221 MoeB interaction surface [polypeptide binding]; other site 502025011222 thiocarboxylated glycine; other site 502025011223 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 502025011224 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025011225 dimer interface [polypeptide binding]; other site 502025011226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011227 catalytic residue [active] 502025011228 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 502025011229 DsrE/DsrF-like family; Region: DrsE; pfam02635 502025011230 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 502025011231 CPxP motif; other site 502025011232 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 502025011233 sulfotransferase; Region: PLN02164 502025011234 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 502025011235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 502025011236 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 502025011237 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 502025011238 Ligand Binding Site [chemical binding]; other site 502025011239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 502025011240 Peptidase M15; Region: Peptidase_M15_3; cl01194 502025011241 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 502025011242 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 502025011243 Flavoprotein; Region: Flavoprotein; pfam02441 502025011244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025011245 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 502025011246 FAD binding site [chemical binding]; other site 502025011247 substrate binding site [chemical binding]; other site 502025011248 catalytic base [active] 502025011249 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 502025011250 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 502025011251 dimer interaction site [polypeptide binding]; other site 502025011252 substrate-binding tunnel; other site 502025011253 active site 502025011254 catalytic site [active] 502025011255 substrate binding site [chemical binding]; other site 502025011256 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 502025011257 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 502025011258 active site 502025011259 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 502025011260 elongation factor G; Reviewed; Region: PRK00007 502025011261 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 502025011262 G1 box; other site 502025011263 putative GEF interaction site [polypeptide binding]; other site 502025011264 GTP/Mg2+ binding site [chemical binding]; other site 502025011265 Switch I region; other site 502025011266 G2 box; other site 502025011267 G3 box; other site 502025011268 Switch II region; other site 502025011269 G4 box; other site 502025011270 G5 box; other site 502025011271 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 502025011272 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 502025011273 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 502025011274 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 502025011275 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 502025011276 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025011277 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 502025011278 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 502025011279 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 502025011280 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025011281 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 502025011282 IMP binding site; other site 502025011283 dimer interface [polypeptide binding]; other site 502025011284 partial ornithine binding site; other site 502025011285 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 502025011286 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 502025011287 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 502025011288 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 502025011289 active site 502025011290 dinuclear metal binding site [ion binding]; other site 502025011291 dimerization interface [polypeptide binding]; other site 502025011292 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 502025011293 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 502025011294 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025011295 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 502025011296 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 502025011297 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 502025011298 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 502025011299 active site 502025011300 TrkA-N domain; Region: TrkA_N; pfam02254 502025011301 TrkA-N domain; Region: TrkA_N; pfam02254 502025011302 hydroperoxidase II; Provisional; Region: katE; PRK11249 502025011303 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 502025011304 tetramer interface [polypeptide binding]; other site 502025011305 heme binding pocket [chemical binding]; other site 502025011306 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 502025011307 domain interactions; other site 502025011308 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 502025011309 Malic enzyme, N-terminal domain; Region: malic; pfam00390 502025011310 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 502025011311 putative NAD(P) binding site [chemical binding]; other site 502025011312 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 502025011313 PilZ domain; Region: PilZ; pfam07238 502025011314 hypothetical protein; Validated; Region: PRK07198 502025011315 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 502025011316 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 502025011317 dimerization interface [polypeptide binding]; other site 502025011318 active site 502025011319 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 502025011320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025011321 active site 502025011322 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011323 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011324 active site 502025011325 ATP binding site [chemical binding]; other site 502025011326 substrate binding site [chemical binding]; other site 502025011327 activation loop (A-loop); other site 502025011328 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025011329 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011330 phosphopeptide binding site; other site 502025011331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025011332 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025011333 Walker A motif; other site 502025011334 ATP binding site [chemical binding]; other site 502025011335 Walker B motif; other site 502025011336 arginine finger; other site 502025011337 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025011338 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011339 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025011340 active site 502025011341 ATP binding site [chemical binding]; other site 502025011342 substrate binding site [chemical binding]; other site 502025011343 activation loop (A-loop); other site 502025011344 PEGA domain; Region: PEGA; pfam08308 502025011345 Lipase (class 2); Region: Lipase_2; pfam01674 502025011346 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025011347 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011348 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025011349 phosphopeptide binding site; other site 502025011350 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025011351 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 502025011352 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 502025011353 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 502025011354 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 502025011355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 502025011356 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 502025011357 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 502025011358 G1 box; other site 502025011359 GTP/Mg2+ binding site [chemical binding]; other site 502025011360 G2 box; other site 502025011361 Switch I region; other site 502025011362 G3 box; other site 502025011363 Switch II region; other site 502025011364 G4 box; other site 502025011365 G5 box; other site 502025011366 Nucleoside recognition; Region: Gate; pfam07670 502025011367 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 502025011368 Nucleoside recognition; Region: Gate; pfam07670 502025011369 FeoA domain; Region: FeoA; pfam04023 502025011370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025011371 sequence-specific DNA binding site [nucleotide binding]; other site 502025011372 salt bridge; other site 502025011373 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 502025011374 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 502025011375 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 502025011376 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 502025011377 active site 502025011378 substrate binding site [chemical binding]; other site 502025011379 metal binding site [ion binding]; metal-binding site 502025011380 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 502025011381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025011382 FeS/SAM binding site; other site 502025011383 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 502025011384 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 502025011385 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 502025011386 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 502025011387 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 502025011388 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 502025011389 intersubunit interface [polypeptide binding]; other site 502025011390 active site 502025011391 Zn2+ binding site [ion binding]; other site 502025011392 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 502025011393 Cupin domain; Region: Cupin_2; pfam07883 502025011394 SPFH domain / Band 7 family; Region: Band_7; pfam01145 502025011395 SPFH domain / Band 7 family; Region: Band_7; pfam01145 502025011396 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 502025011397 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025011398 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025011399 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025011400 Predicted membrane protein [Function unknown]; Region: COG1288 502025011401 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 502025011402 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 502025011403 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 502025011404 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 502025011405 active site 502025011406 phosphorylation site [posttranslational modification] 502025011407 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 502025011408 LabA_like proteins; Region: LabA_like; cd06167 502025011409 Uncharacterized conserved protein [Function unknown]; Region: COG1432 502025011410 putative metal binding site [ion binding]; other site 502025011411 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025011412 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 502025011413 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 502025011414 G1 box; other site 502025011415 putative GEF interaction site [polypeptide binding]; other site 502025011416 GTP/Mg2+ binding site [chemical binding]; other site 502025011417 Switch I region; other site 502025011418 G2 box; other site 502025011419 G3 box; other site 502025011420 Switch II region; other site 502025011421 G4 box; other site 502025011422 G5 box; other site 502025011423 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 502025011424 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 502025011425 malate dehydrogenase; Provisional; Region: PRK05442 502025011426 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 502025011427 NAD(P) binding site [chemical binding]; other site 502025011428 dimer interface [polypeptide binding]; other site 502025011429 malate binding site [chemical binding]; other site 502025011430 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 502025011431 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 502025011432 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025011433 S-adenosylmethionine synthetase; Validated; Region: PRK05250 502025011434 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 502025011435 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 502025011436 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 502025011437 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 502025011438 histidinol dehydrogenase; Region: hisD; TIGR00069 502025011439 NAD binding site [chemical binding]; other site 502025011440 dimerization interface [polypeptide binding]; other site 502025011441 product binding site; other site 502025011442 substrate binding site [chemical binding]; other site 502025011443 zinc binding site [ion binding]; other site 502025011444 catalytic residues [active] 502025011445 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025011446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025011447 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 502025011448 FeS/SAM binding site; other site 502025011449 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 502025011450 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025011451 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025011452 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025011453 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025011454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025011455 ATP binding site [chemical binding]; other site 502025011456 G-X-G motif; other site 502025011457 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025011458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011459 active site 502025011460 phosphorylation site [posttranslational modification] 502025011461 intermolecular recognition site; other site 502025011462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025011463 Walker A motif; other site 502025011464 ATP binding site [chemical binding]; other site 502025011465 Walker B motif; other site 502025011466 arginine finger; other site 502025011467 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 502025011468 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011469 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011470 active site 502025011471 ATP binding site [chemical binding]; other site 502025011472 substrate binding site [chemical binding]; other site 502025011473 activation loop (A-loop); other site 502025011474 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 502025011475 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025011476 putative active site [active] 502025011477 putative metal binding site [ion binding]; other site 502025011478 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 502025011479 Ca binding site [ion binding]; other site 502025011480 ligand binding site I [chemical binding]; other site 502025011481 homodimer interface [polypeptide binding]; other site 502025011482 ligand binding site II [chemical binding]; other site 502025011483 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 502025011484 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 502025011485 Ca binding site [ion binding]; other site 502025011486 ligand binding site I [chemical binding]; other site 502025011487 homodimer interface [polypeptide binding]; other site 502025011488 ligand binding site II [chemical binding]; other site 502025011489 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025011490 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025011491 ligand binding site [chemical binding]; other site 502025011492 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 502025011493 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 502025011494 MOFRL family; Region: MOFRL; pfam05161 502025011495 trehalose synthase; Region: treS_nterm; TIGR02456 502025011496 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 502025011497 Ca binding site [ion binding]; other site 502025011498 active site 502025011499 catalytic site [active] 502025011500 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025011501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025011502 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 502025011503 DNA binding residues [nucleotide binding] 502025011504 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 502025011505 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 502025011506 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 502025011507 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025011508 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011509 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011510 active site 502025011511 ATP binding site [chemical binding]; other site 502025011512 substrate binding site [chemical binding]; other site 502025011513 activation loop (A-loop); other site 502025011514 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025011515 active site 502025011516 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025011517 catalytic tetrad [active] 502025011518 Predicted membrane protein [Function unknown]; Region: COG4270 502025011519 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 502025011520 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 502025011521 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 502025011522 Cu(I) binding site [ion binding]; other site 502025011523 Cytochrome c; Region: Cytochrom_C; pfam00034 502025011524 acetylglutamate kinase; Provisional; Region: PRK04531 502025011525 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 502025011526 nucleotide binding site [chemical binding]; other site 502025011527 substrate binding site [chemical binding]; other site 502025011528 Protein of unknown function (DUF619); Region: DUF619; pfam04768 502025011529 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 502025011530 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 502025011531 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 502025011532 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 502025011533 NADP binding site [chemical binding]; other site 502025011534 substrate binding site [chemical binding]; other site 502025011535 active site 502025011536 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 502025011537 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025011538 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 502025011539 NAD binding site [chemical binding]; other site 502025011540 Phe binding site; other site 502025011541 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025011542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025011543 non-specific DNA binding site [nucleotide binding]; other site 502025011544 salt bridge; other site 502025011545 sequence-specific DNA binding site [nucleotide binding]; other site 502025011546 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 502025011547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025011548 Walker A/P-loop; other site 502025011549 ATP binding site [chemical binding]; other site 502025011550 Q-loop/lid; other site 502025011551 ABC transporter signature motif; other site 502025011552 Walker B; other site 502025011553 D-loop; other site 502025011554 H-loop/switch region; other site 502025011555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025011556 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 502025011557 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 502025011558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 502025011559 PBP superfamily domain; Region: PBP_like; pfam12727 502025011560 RNA polymerase factor sigma-70; Validated; Region: PRK08241 502025011561 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025011562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025011563 DNA binding residues [nucleotide binding] 502025011564 SnoaL-like domain; Region: SnoaL_2; pfam12680 502025011565 Penicillinase repressor; Region: Pencillinase_R; pfam03965 502025011566 Outer membrane efflux protein; Region: OEP; pfam02321 502025011567 Outer membrane efflux protein; Region: OEP; pfam02321 502025011568 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 502025011569 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 502025011570 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025011571 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025011572 Helix-turn-helix domain; Region: HTH_18; pfam12833 502025011573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025011574 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 502025011575 dimer interface [polypeptide binding]; other site 502025011576 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025011577 ligand binding site [chemical binding]; other site 502025011578 MbtH-like protein; Region: MbtH; cl01279 502025011579 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 502025011580 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 502025011581 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 502025011582 Walker A/P-loop; other site 502025011583 ATP binding site [chemical binding]; other site 502025011584 Q-loop/lid; other site 502025011585 ABC transporter signature motif; other site 502025011586 Walker B; other site 502025011587 D-loop; other site 502025011588 H-loop/switch region; other site 502025011589 TOBE domain; Region: TOBE_2; pfam08402 502025011590 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 502025011591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025011592 dimer interface [polypeptide binding]; other site 502025011593 conserved gate region; other site 502025011594 ABC-ATPase subunit interface; other site 502025011595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025011596 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 502025011597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025011598 dimer interface [polypeptide binding]; other site 502025011599 conserved gate region; other site 502025011600 putative PBP binding loops; other site 502025011601 ABC-ATPase subunit interface; other site 502025011602 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 502025011603 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 502025011604 Right handed beta helix region; Region: Beta_helix; pfam13229 502025011605 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 502025011606 GAF domain; Region: GAF_3; pfam13492 502025011607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025011608 Walker A motif; other site 502025011609 ATP binding site [chemical binding]; other site 502025011610 Walker B motif; other site 502025011611 arginine finger; other site 502025011612 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 502025011613 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025011614 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025011615 active site 502025011616 metal binding site [ion binding]; metal-binding site 502025011617 Cytochrome c [Energy production and conversion]; Region: COG3258 502025011618 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025011619 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025011620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025011621 ethanolamine permease; Region: 2A0305; TIGR00908 502025011622 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 502025011623 tyrosine decarboxylase; Region: PLN02880 502025011624 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 502025011625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011626 catalytic residue [active] 502025011627 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025011628 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 502025011629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025011630 catalytic residue [active] 502025011631 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 502025011632 Peptidase family M50; Region: Peptidase_M50; pfam02163 502025011633 active site 502025011634 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 502025011635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025011636 S-adenosylmethionine binding site [chemical binding]; other site 502025011637 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 502025011638 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025011639 active site residue [active] 502025011640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025011641 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025011642 active site residue [active] 502025011643 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 502025011644 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 502025011645 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 502025011646 active site 502025011647 catalytic residues [active] 502025011648 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 502025011649 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025011650 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025011651 Cytochrome P450; Region: p450; cl12078 502025011652 GTPases [General function prediction only]; Region: HflX; COG2262 502025011653 HflX GTPase family; Region: HflX; cd01878 502025011654 G1 box; other site 502025011655 GTP/Mg2+ binding site [chemical binding]; other site 502025011656 Switch I region; other site 502025011657 G2 box; other site 502025011658 G3 box; other site 502025011659 Switch II region; other site 502025011660 G4 box; other site 502025011661 G5 box; other site 502025011662 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025011663 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011664 active site 502025011665 ATP binding site [chemical binding]; other site 502025011666 substrate binding site [chemical binding]; other site 502025011667 activation loop (A-loop); other site 502025011668 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025011669 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025011670 active site 502025011671 ATP binding site [chemical binding]; other site 502025011672 substrate binding site [chemical binding]; other site 502025011673 activation loop (A-loop); other site 502025011674 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 502025011675 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 502025011676 homotetramer interface [polypeptide binding]; other site 502025011677 ligand binding site [chemical binding]; other site 502025011678 catalytic site [active] 502025011679 NAD binding site [chemical binding]; other site 502025011680 Homeodomain-like domain; Region: HTH_23; pfam13384 502025011681 Winged helix-turn helix; Region: HTH_29; pfam13551 502025011682 Homeodomain-like domain; Region: HTH_32; pfam13565 502025011683 Integrase core domain; Region: rve; pfam00665 502025011684 Integrase core domain; Region: rve_3; pfam13683 502025011685 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 502025011686 Fatty acid desaturase; Region: FA_desaturase; pfam00487 502025011687 putative di-iron ligands [ion binding]; other site 502025011688 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025011689 B12 binding site [chemical binding]; other site 502025011690 aspartate semialdehyde dehydrogenase; Region: PLN02383 502025011691 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 502025011692 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 502025011693 nucleotide binding site [chemical binding]; other site 502025011694 substrate binding site [chemical binding]; other site 502025011695 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 502025011696 substrate binding site [chemical binding]; other site 502025011697 B12 cofactor binding site [chemical binding]; other site 502025011698 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 502025011699 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 502025011700 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 502025011701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025011702 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 502025011703 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025011704 inhibitor-cofactor binding pocket; inhibition site 502025011705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011706 catalytic residue [active] 502025011707 EamA-like transporter family; Region: EamA; pfam00892 502025011708 EamA-like transporter family; Region: EamA; pfam00892 502025011709 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025011710 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025011711 phosphopeptide binding site; other site 502025011712 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025011713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025011714 Walker A motif; other site 502025011715 ATP binding site [chemical binding]; other site 502025011716 Walker B motif; other site 502025011717 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 502025011718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025011719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025011720 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 502025011721 active site 502025011722 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 502025011723 Protein of unknown function (DUF971); Region: DUF971; cl01414 502025011724 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 502025011725 substrate binding pocket [chemical binding]; other site 502025011726 active site 502025011727 iron coordination sites [ion binding]; other site 502025011728 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 502025011729 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025011730 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025011731 NAD(P) binding site [chemical binding]; other site 502025011732 catalytic residues [active] 502025011733 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 502025011734 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 502025011735 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025011736 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 502025011737 putative dimer interface [polypeptide binding]; other site 502025011738 AAA domain; Region: AAA_33; pfam13671 502025011739 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 502025011740 active site 502025011741 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 502025011742 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 502025011743 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025011744 CpXC protein; Region: CpXC; pfam14353 502025011745 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025011746 Flagellin N-methylase; Region: FliB; pfam03692 502025011747 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 502025011748 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 502025011749 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025011750 Peptidase family M48; Region: Peptidase_M48; cl12018 502025011751 Penicillinase repressor; Region: Pencillinase_R; cl17580 502025011752 Hemerythrin-like domain; Region: Hr-like; cd12108 502025011753 Fe binding site [ion binding]; other site 502025011754 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 502025011755 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 502025011756 dimer interface [polypeptide binding]; other site 502025011757 active site 502025011758 Uncharacterized conserved protein [Function unknown]; Region: COG4850 502025011759 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 502025011760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 502025011761 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 502025011762 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025011763 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025011764 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025011765 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025011766 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025011767 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025011768 catalytic loop [active] 502025011769 iron binding site [ion binding]; other site 502025011770 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025011771 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 502025011772 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 502025011773 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025011774 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025011775 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025011776 Stage II sporulation protein; Region: SpoIID; pfam08486 502025011777 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 502025011778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025011779 Coenzyme A binding pocket [chemical binding]; other site 502025011780 short chain dehydrogenase; Provisional; Region: PRK06172 502025011781 classical (c) SDRs; Region: SDR_c; cd05233 502025011782 NAD(P) binding site [chemical binding]; other site 502025011783 active site 502025011784 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 502025011785 active site clefts [active] 502025011786 zinc binding site [ion binding]; other site 502025011787 dimer interface [polypeptide binding]; other site 502025011788 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 502025011789 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 502025011790 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 502025011791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 502025011792 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 502025011793 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 502025011794 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 502025011795 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 502025011796 Sulfate transporter family; Region: Sulfate_transp; pfam00916 502025011797 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 502025011798 Transcriptional regulators [Transcription]; Region: MarR; COG1846 502025011799 MarR family; Region: MarR_2; cl17246 502025011800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025011801 Major Facilitator Superfamily; Region: MFS_1; pfam07690 502025011802 putative substrate translocation pore; other site 502025011803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025011804 Predicted peptidase [General function prediction only]; Region: COG4099 502025011805 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 502025011806 hypothetical protein; Provisional; Region: PRK08317 502025011807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025011808 S-adenosylmethionine binding site [chemical binding]; other site 502025011809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025011810 S-adenosylmethionine binding site [chemical binding]; other site 502025011811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011812 NAD(P) binding site [chemical binding]; other site 502025011813 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025011814 active site 502025011815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025011816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025011817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 502025011818 dimerization interface [polypeptide binding]; other site 502025011819 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 502025011820 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 502025011821 dimer interface [polypeptide binding]; other site 502025011822 substrate binding site [chemical binding]; other site 502025011823 metal binding sites [ion binding]; metal-binding site 502025011824 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 502025011825 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 502025011826 heme binding site [chemical binding]; other site 502025011827 ferroxidase pore; other site 502025011828 ferroxidase diiron center [ion binding]; other site 502025011829 methionine sulfoxide reductase A; Provisional; Region: PRK00058 502025011830 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 502025011831 Hexamer/Pentamer interface [polypeptide binding]; other site 502025011832 central pore; other site 502025011833 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 502025011834 Hexamer/Pentamer interface [polypeptide binding]; other site 502025011835 central pore; other site 502025011836 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 502025011837 intersubunit interface [polypeptide binding]; other site 502025011838 active site 502025011839 Zn2+ binding site [ion binding]; other site 502025011840 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 502025011841 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 502025011842 domain interfaces; other site 502025011843 active site 502025011844 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 502025011845 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 502025011846 active site 502025011847 intersubunit interface [polypeptide binding]; other site 502025011848 catalytic residue [active] 502025011849 phosphogluconate dehydratase; Validated; Region: PRK09054 502025011850 6-phosphogluconate dehydratase; Region: edd; TIGR01196 502025011851 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 502025011852 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 502025011853 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 502025011854 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 502025011855 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 502025011856 putative active site [active] 502025011857 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025011858 putative catalytic site [active] 502025011859 putative metal binding site [ion binding]; other site 502025011860 putative phosphate binding site [ion binding]; other site 502025011861 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 502025011862 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 502025011863 Transglycosylase; Region: Transgly; pfam00912 502025011864 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 502025011865 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025011866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025011867 dimerization interface [polypeptide binding]; other site 502025011868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025011869 dimer interface [polypeptide binding]; other site 502025011870 phosphorylation site [posttranslational modification] 502025011871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025011872 ATP binding site [chemical binding]; other site 502025011873 G-X-G motif; other site 502025011874 Response regulator receiver domain; Region: Response_reg; pfam00072 502025011875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011876 active site 502025011877 phosphorylation site [posttranslational modification] 502025011878 intermolecular recognition site; other site 502025011879 dimerization interface [polypeptide binding]; other site 502025011880 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 502025011881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025011882 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025011883 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025011884 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 502025011885 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025011886 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 502025011887 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 502025011888 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 502025011889 active site 502025011890 catalytic site [active] 502025011891 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025011892 anti sigma factor interaction site; other site 502025011893 regulatory phosphorylation site [posttranslational modification]; other site 502025011894 Response regulator receiver domain; Region: Response_reg; pfam00072 502025011895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025011896 active site 502025011897 phosphorylation site [posttranslational modification] 502025011898 intermolecular recognition site; other site 502025011899 dimerization interface [polypeptide binding]; other site 502025011900 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025011901 GAF domain; Region: GAF_3; pfam13492 502025011902 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 502025011903 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025011904 Zn2+ binding site [ion binding]; other site 502025011905 Mg2+ binding site [ion binding]; other site 502025011906 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 502025011907 nucleotide binding site [chemical binding]; other site 502025011908 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025011909 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025011910 catalytic residues [active] 502025011911 conserved hypothetical protein; Region: TIGR03843 502025011912 HEAT repeats; Region: HEAT_2; pfam13646 502025011913 HEAT repeats; Region: HEAT_2; pfam13646 502025011914 Major Facilitator Superfamily; Region: MFS_1; pfam07690 502025011915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025011916 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025011917 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025011918 active site 502025011919 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 502025011920 Protein of unknown function (DUF523); Region: DUF523; pfam04463 502025011921 Uncharacterized conserved protein [Function unknown]; Region: COG3272 502025011922 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 502025011923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025011924 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 502025011925 NAD(P) binding site [chemical binding]; other site 502025011926 active site 502025011927 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 502025011928 putative hydrophobic ligand binding site [chemical binding]; other site 502025011929 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025011930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025011931 non-specific DNA binding site [nucleotide binding]; other site 502025011932 salt bridge; other site 502025011933 sequence-specific DNA binding site [nucleotide binding]; other site 502025011934 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 502025011935 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025011936 FOG: CBS domain [General function prediction only]; Region: COG0517 502025011937 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025011938 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025011939 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025011940 ligand binding site [chemical binding]; other site 502025011941 flexible hinge region; other site 502025011942 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 502025011943 trimer interface [polypeptide binding]; other site 502025011944 dimer interface [polypeptide binding]; other site 502025011945 putative active site [active] 502025011946 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 502025011947 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 502025011948 glutaminase active site [active] 502025011949 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 502025011950 dimer interface [polypeptide binding]; other site 502025011951 active site 502025011952 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 502025011953 dimer interface [polypeptide binding]; other site 502025011954 active site 502025011955 Ubiquitin-like proteins; Region: UBQ; cl00155 502025011956 BNR repeat-like domain; Region: BNR_2; pfam13088 502025011957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025011958 TPR motif; other site 502025011959 binding surface 502025011960 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 502025011961 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 502025011962 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 502025011963 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 502025011964 GDP-binding site [chemical binding]; other site 502025011965 ACT binding site; other site 502025011966 IMP binding site; other site 502025011967 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 502025011968 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 502025011969 dimer interface [polypeptide binding]; other site 502025011970 motif 1; other site 502025011971 active site 502025011972 motif 3; other site 502025011973 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 502025011974 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 502025011975 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 502025011976 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 502025011977 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 502025011978 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025011979 inhibitor-cofactor binding pocket; inhibition site 502025011980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025011981 catalytic residue [active] 502025011982 DNA gyrase subunit A; Validated; Region: PRK05560 502025011983 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 502025011984 CAP-like domain; other site 502025011985 active site 502025011986 primary dimer interface [polypeptide binding]; other site 502025011987 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011988 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011989 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011990 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011991 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 502025011992 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 502025011993 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 502025011994 catalytic residues [active] 502025011995 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 502025011996 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025011997 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 502025011998 NAD(P) binding site [chemical binding]; other site 502025011999 catalytic residues [active] 502025012000 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 502025012001 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 502025012002 active site 502025012003 catalytic residues [active] 502025012004 metal binding site [ion binding]; metal-binding site 502025012005 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 502025012006 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 502025012007 substrate binding site [chemical binding]; other site 502025012008 ligand binding site [chemical binding]; other site 502025012009 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 502025012010 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 502025012011 substrate binding site [chemical binding]; other site 502025012012 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 502025012013 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 502025012014 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 502025012015 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 502025012016 active site 502025012017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025012018 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025012019 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025012020 P-loop; other site 502025012021 Magnesium ion binding site [ion binding]; other site 502025012022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025012023 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025012024 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 502025012025 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025012026 putative active site pocket [active] 502025012027 dimerization interface [polypeptide binding]; other site 502025012028 putative catalytic residue [active] 502025012029 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 502025012030 lipoprotein signal peptidase; Provisional; Region: PRK14787 502025012031 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 502025012032 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 502025012033 catalytic motif [active] 502025012034 Zn binding site [ion binding]; other site 502025012035 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 502025012036 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 502025012037 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025012038 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025012039 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025012040 Cation efflux family; Region: Cation_efflux; pfam01545 502025012041 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 502025012042 HIT family signature motif; other site 502025012043 catalytic residue [active] 502025012044 Trm112p-like protein; Region: Trm112p; cl01066 502025012045 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 502025012046 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025012047 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 502025012048 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 502025012049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025012050 active site 502025012051 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 502025012052 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 502025012053 5S rRNA interface [nucleotide binding]; other site 502025012054 CTC domain interface [polypeptide binding]; other site 502025012055 L16 interface [polypeptide binding]; other site 502025012056 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 502025012057 putative active site [active] 502025012058 catalytic residue [active] 502025012059 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 502025012060 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 502025012061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 502025012062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 502025012063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 502025012064 replicative DNA helicase; Region: DnaB; TIGR00665 502025012065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 502025012066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 502025012067 Walker A motif; other site 502025012068 ATP binding site [chemical binding]; other site 502025012069 Walker B motif; other site 502025012070 DNA binding loops [nucleotide binding] 502025012071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025012072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012073 active site 502025012074 ATP binding site [chemical binding]; other site 502025012075 substrate binding site [chemical binding]; other site 502025012076 activation loop (A-loop); other site 502025012077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025012078 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 502025012079 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 502025012080 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025012081 DNA binding residues [nucleotide binding] 502025012082 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 502025012083 TPR repeat; Region: TPR_11; pfam13414 502025012084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012085 binding surface 502025012086 TPR motif; other site 502025012087 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 502025012088 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 502025012089 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 502025012090 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 502025012091 N-acetyl-D-glucosamine binding site [chemical binding]; other site 502025012092 catalytic residue [active] 502025012093 L-aspartate oxidase; Provisional; Region: PRK09077 502025012094 L-aspartate oxidase; Provisional; Region: PRK06175 502025012095 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 502025012096 4Fe-4S binding domain; Region: Fer4; pfam00037 502025012097 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 502025012098 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 502025012099 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025012100 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 502025012101 catalytic loop [active] 502025012102 iron binding site [ion binding]; other site 502025012103 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 502025012104 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025012105 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025012106 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 502025012107 NADH dehydrogenase subunit D; Validated; Region: PRK06075 502025012108 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 502025012109 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 502025012110 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 502025012111 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 502025012112 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025012113 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025012114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025012115 catalytic residue [active] 502025012116 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 502025012117 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025012118 Beta propeller domain; Region: Beta_propel; pfam09826 502025012119 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 502025012120 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 502025012121 Na binding site [ion binding]; other site 502025012122 putative substrate binding site [chemical binding]; other site 502025012123 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 502025012124 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 502025012125 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 502025012126 DNA binding site [nucleotide binding] 502025012127 domain linker motif; other site 502025012128 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 502025012129 dimerization interface [polypeptide binding]; other site 502025012130 ligand binding site [chemical binding]; other site 502025012131 Biofilm formation and stress response factor; Region: BsmA; pfam10014 502025012132 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 502025012133 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 502025012134 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 502025012135 xylulokinase; Provisional; Region: PRK15027 502025012136 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 502025012137 N- and C-terminal domain interface [polypeptide binding]; other site 502025012138 active site 502025012139 MgATP binding site [chemical binding]; other site 502025012140 catalytic site [active] 502025012141 metal binding site [ion binding]; metal-binding site 502025012142 xylulose binding site [chemical binding]; other site 502025012143 homodimer interface [polypeptide binding]; other site 502025012144 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 502025012145 active site 502025012146 catalytic residues [active] 502025012147 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 502025012148 Ca binding site [ion binding]; other site 502025012149 ligand binding site I [chemical binding]; other site 502025012150 homodimer interface [polypeptide binding]; other site 502025012151 ligand binding site II [chemical binding]; other site 502025012152 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025012153 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025012154 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025012155 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025012156 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025012157 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025012158 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025012159 catalytic loop [active] 502025012160 iron binding site [ion binding]; other site 502025012161 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025012162 Uncharacterized conserved protein [Function unknown]; Region: COG3791 502025012163 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 502025012164 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 502025012165 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 502025012166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025012167 inhibitor-cofactor binding pocket; inhibition site 502025012168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025012169 catalytic residue [active] 502025012170 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 502025012171 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 502025012172 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025012173 NAD(P) binding site [chemical binding]; other site 502025012174 catalytic residues [active] 502025012175 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025012176 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 502025012177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025012178 catalytic residue [active] 502025012179 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 502025012180 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025012181 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025012182 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012183 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025012184 phosphopeptide binding site; other site 502025012185 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025012186 GAF domain; Region: GAF; pfam01590 502025012187 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 502025012188 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025012189 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 502025012190 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 502025012191 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 502025012192 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 502025012193 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 502025012194 catalytic site [active] 502025012195 active site 502025012196 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 502025012197 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025012198 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 502025012199 active site 502025012200 catalytic site [active] 502025012201 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 502025012202 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 502025012203 putative hydrophobic ligand binding site [chemical binding]; other site 502025012204 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 502025012205 putative MPT binding site; other site 502025012206 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 502025012207 metal-binding site 502025012208 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 502025012209 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 502025012210 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 502025012211 XdhC Rossmann domain; Region: XdhC_C; pfam13478 502025012212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025012213 dimerization interface [polypeptide binding]; other site 502025012214 putative DNA binding site [nucleotide binding]; other site 502025012215 putative Zn2+ binding site [ion binding]; other site 502025012216 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 502025012217 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 502025012218 active site 502025012219 Zn2+ binding site [ion binding]; other site 502025012220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012221 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012222 active site 502025012223 ATP binding site [chemical binding]; other site 502025012224 substrate binding site [chemical binding]; other site 502025012225 activation loop (A-loop); other site 502025012226 HEAT repeats; Region: HEAT_2; pfam13646 502025012227 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012228 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025012229 phosphopeptide binding site; other site 502025012230 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025012231 GAF domain; Region: GAF; pfam01590 502025012232 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 502025012233 cyclase homology domain; Region: CHD; cd07302 502025012234 nucleotidyl binding site; other site 502025012235 metal binding site [ion binding]; metal-binding site 502025012236 dimer interface [polypeptide binding]; other site 502025012237 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 502025012238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012239 binding surface 502025012240 TPR motif; other site 502025012241 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025012242 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025012243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012244 binding surface 502025012245 TPR motif; other site 502025012246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012247 binding surface 502025012248 TPR motif; other site 502025012249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012250 binding surface 502025012251 TPR motif; other site 502025012252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012253 binding surface 502025012254 TPR motif; other site 502025012255 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 502025012256 Nitrogen regulatory protein P-II; Region: P-II; smart00938 502025012257 glutamine synthetase, type I; Region: GlnA; TIGR00653 502025012258 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 502025012259 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 502025012260 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025012261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012262 dimer interface [polypeptide binding]; other site 502025012263 phosphorylation site [posttranslational modification] 502025012264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012265 ATP binding site [chemical binding]; other site 502025012266 Mg2+ binding site [ion binding]; other site 502025012267 G-X-G motif; other site 502025012268 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012270 active site 502025012271 phosphorylation site [posttranslational modification] 502025012272 intermolecular recognition site; other site 502025012273 dimerization interface [polypeptide binding]; other site 502025012274 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 502025012275 PhoU domain; Region: PhoU; pfam01895 502025012276 PhoU domain; Region: PhoU; pfam01895 502025012277 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 502025012278 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 502025012279 Walker A/P-loop; other site 502025012280 ATP binding site [chemical binding]; other site 502025012281 Q-loop/lid; other site 502025012282 ABC transporter signature motif; other site 502025012283 Walker B; other site 502025012284 D-loop; other site 502025012285 H-loop/switch region; other site 502025012286 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 502025012287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025012288 dimer interface [polypeptide binding]; other site 502025012289 conserved gate region; other site 502025012290 putative PBP binding loops; other site 502025012291 ABC-ATPase subunit interface; other site 502025012292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025012293 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 502025012294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025012295 dimer interface [polypeptide binding]; other site 502025012296 conserved gate region; other site 502025012297 putative PBP binding loops; other site 502025012298 ABC-ATPase subunit interface; other site 502025012299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025012300 PBP superfamily domain; Region: PBP_like_2; cl17296 502025012301 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 502025012302 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 502025012303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025012304 S-adenosylmethionine binding site [chemical binding]; other site 502025012305 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 502025012306 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 502025012307 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 502025012308 Probable Catalytic site; other site 502025012309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025012310 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025012311 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 502025012312 PilZ domain; Region: PilZ; cl01260 502025012313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 502025012314 active site 502025012315 dimerization interface [polypeptide binding]; other site 502025012316 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 502025012317 ParB-like nuclease domain; Region: ParB; smart00470 502025012318 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025012319 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025012320 P-loop; other site 502025012321 Magnesium ion binding site [ion binding]; other site 502025012322 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025012323 Magnesium ion binding site [ion binding]; other site 502025012324 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012325 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025012326 phosphopeptide binding site; other site 502025012327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012328 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025012329 Walker A motif; other site 502025012330 ATP binding site [chemical binding]; other site 502025012331 Walker B motif; other site 502025012332 arginine finger; other site 502025012333 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025012334 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025012335 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025012336 ligand binding site [chemical binding]; other site 502025012337 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025012338 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025012339 catalytic residues [active] 502025012340 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 502025012341 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 502025012342 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 502025012343 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025012344 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 502025012345 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025012346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025012347 homodimer interface [polypeptide binding]; other site 502025012348 catalytic residue [active] 502025012349 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06035 502025012350 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025012351 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025012352 enoyl-CoA hydratase; Provisional; Region: PRK07658 502025012353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025012354 substrate binding site [chemical binding]; other site 502025012355 trimer interface [polypeptide binding]; other site 502025012356 oxyanion hole (OAH) forming residues; other site 502025012357 putative acyltransferase; Provisional; Region: PRK05790 502025012358 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025012359 dimer interface [polypeptide binding]; other site 502025012360 active site 502025012361 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 502025012362 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 502025012363 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 502025012364 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 502025012365 ligand binding site [chemical binding]; other site 502025012366 NAD binding site [chemical binding]; other site 502025012367 tetramer interface [polypeptide binding]; other site 502025012368 catalytic site [active] 502025012369 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 502025012370 L-serine binding site [chemical binding]; other site 502025012371 ACT domain interface; other site 502025012372 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 502025012373 active site 502025012374 metal binding site [ion binding]; metal-binding site 502025012375 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 502025012376 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025012377 5'-3' exonuclease; Region: 53EXOc; smart00475 502025012378 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 502025012379 active site 502025012380 metal binding site 1 [ion binding]; metal-binding site 502025012381 putative 5' ssDNA interaction site; other site 502025012382 metal binding site 3; metal-binding site 502025012383 metal binding site 2 [ion binding]; metal-binding site 502025012384 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 502025012385 putative DNA binding site [nucleotide binding]; other site 502025012386 putative metal binding site [ion binding]; other site 502025012387 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 502025012388 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 502025012389 active site 502025012390 substrate binding site [chemical binding]; other site 502025012391 catalytic site [active] 502025012392 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 502025012393 active site 502025012394 DNA binding site [nucleotide binding] 502025012395 catalytic site [active] 502025012396 PilZ domain; Region: PilZ; pfam07238 502025012397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012398 TPR motif; other site 502025012399 binding surface 502025012400 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025012401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012402 TPR motif; other site 502025012403 binding surface 502025012404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012405 binding surface 502025012406 TPR motif; other site 502025012407 TPR repeat; Region: TPR_11; pfam13414 502025012408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012409 binding surface 502025012410 TPR motif; other site 502025012411 TPR repeat; Region: TPR_11; pfam13414 502025012412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012413 binding surface 502025012414 TPR motif; other site 502025012415 HEAT repeats; Region: HEAT_2; pfam13646 502025012416 FHA domain; Region: FHA; pfam00498 502025012417 phosphopeptide binding site; other site 502025012418 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025012419 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012420 phosphopeptide binding site; other site 502025012421 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 502025012422 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012423 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025012424 phosphopeptide binding site; other site 502025012425 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012426 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025012427 phosphopeptide binding site; other site 502025012428 Transglycosylase; Region: Transgly; pfam00912 502025012429 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 502025012430 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025012431 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012432 phosphopeptide binding site; other site 502025012433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012434 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025012435 Walker A motif; other site 502025012436 ATP binding site [chemical binding]; other site 502025012437 Walker B motif; other site 502025012438 arginine finger; other site 502025012439 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025012440 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012441 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012442 active site 502025012443 ATP binding site [chemical binding]; other site 502025012444 substrate binding site [chemical binding]; other site 502025012445 activation loop (A-loop); other site 502025012446 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012448 active site 502025012449 phosphorylation site [posttranslational modification] 502025012450 intermolecular recognition site; other site 502025012451 dimerization interface [polypeptide binding]; other site 502025012452 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 502025012453 cyclase homology domain; Region: CHD; cd07302 502025012454 dimer interface [polypeptide binding]; other site 502025012455 nucleotidyl binding site; other site 502025012456 metal binding site [ion binding]; metal-binding site 502025012457 Protein kinase domain; Region: Pkinase; pfam00069 502025012458 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012459 active site 502025012460 ATP binding site [chemical binding]; other site 502025012461 substrate binding site [chemical binding]; other site 502025012462 activation loop (A-loop); other site 502025012463 AAA ATPase domain; Region: AAA_16; pfam13191 502025012464 Predicted ATPase [General function prediction only]; Region: COG3899 502025012465 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025012466 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025012467 GAF domain; Region: GAF; cl17456 502025012468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012469 ATP binding site [chemical binding]; other site 502025012470 Mg2+ binding site [ion binding]; other site 502025012471 G-X-G motif; other site 502025012472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012473 TPR motif; other site 502025012474 binding surface 502025012475 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 502025012476 homodimer interface [polypeptide binding]; other site 502025012477 active site 502025012478 SAM binding site [chemical binding]; other site 502025012479 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 502025012480 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 502025012481 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025012482 dimer interface [polypeptide binding]; other site 502025012483 active site 502025012484 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025012485 Ligand Binding Site [chemical binding]; other site 502025012486 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025012487 Ligand Binding Site [chemical binding]; other site 502025012488 Ferredoxin [Energy production and conversion]; Region: COG1146 502025012489 4Fe-4S binding domain; Region: Fer4; cl02805 502025012490 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 502025012491 DNA protecting protein DprA; Region: dprA; TIGR00732 502025012492 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 502025012493 DNA topoisomerase I; Validated; Region: PRK06599 502025012494 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 502025012495 active site 502025012496 interdomain interaction site; other site 502025012497 putative metal-binding site [ion binding]; other site 502025012498 nucleotide binding site [chemical binding]; other site 502025012499 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 502025012500 domain I; other site 502025012501 DNA binding groove [nucleotide binding] 502025012502 phosphate binding site [ion binding]; other site 502025012503 domain II; other site 502025012504 domain III; other site 502025012505 nucleotide binding site [chemical binding]; other site 502025012506 catalytic site [active] 502025012507 domain IV; other site 502025012508 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 502025012509 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 502025012510 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 502025012511 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 502025012512 Glucose inhibited division protein A; Region: GIDA; pfam01134 502025012513 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 502025012514 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 502025012515 classical (c) SDRs; Region: SDR_c; cd05233 502025012516 NAD(P) binding site [chemical binding]; other site 502025012517 active site 502025012518 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 502025012519 CheB methylesterase; Region: CheB_methylest; pfam01339 502025012520 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025012521 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025012522 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 502025012523 PAS domain; Region: PAS_10; pfam13596 502025012524 PAS domain S-box; Region: sensory_box; TIGR00229 502025012525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025012526 putative active site [active] 502025012527 heme pocket [chemical binding]; other site 502025012528 PAS fold; Region: PAS_4; pfam08448 502025012529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025012530 putative active site [active] 502025012531 heme pocket [chemical binding]; other site 502025012532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025012533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012534 dimer interface [polypeptide binding]; other site 502025012535 phosphorylation site [posttranslational modification] 502025012536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012537 ATP binding site [chemical binding]; other site 502025012538 Mg2+ binding site [ion binding]; other site 502025012539 G-X-G motif; other site 502025012540 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012542 active site 502025012543 phosphorylation site [posttranslational modification] 502025012544 intermolecular recognition site; other site 502025012545 dimerization interface [polypeptide binding]; other site 502025012546 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 502025012547 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 502025012548 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025012549 active site 502025012550 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 502025012551 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 502025012552 Tetratricopeptide repeat; Region: TPR_6; pfam13174 502025012553 TPR repeat; Region: TPR_11; pfam13414 502025012554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012555 binding surface 502025012556 TPR motif; other site 502025012557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025012558 TPR repeat; Region: TPR_11; pfam13414 502025012559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025012560 binding surface 502025012561 TPR motif; other site 502025012562 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025012563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025012564 dimer interface [polypeptide binding]; other site 502025012565 phosphorylation site [posttranslational modification] 502025012566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012567 ATP binding site [chemical binding]; other site 502025012568 Mg2+ binding site [ion binding]; other site 502025012569 G-X-G motif; other site 502025012570 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012572 active site 502025012573 phosphorylation site [posttranslational modification] 502025012574 intermolecular recognition site; other site 502025012575 dimerization interface [polypeptide binding]; other site 502025012576 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025012577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012578 active site 502025012579 phosphorylation site [posttranslational modification] 502025012580 intermolecular recognition site; other site 502025012581 dimerization interface [polypeptide binding]; other site 502025012582 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025012583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025012584 putative active site [active] 502025012585 heme pocket [chemical binding]; other site 502025012586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012587 ATP binding site [chemical binding]; other site 502025012588 Mg2+ binding site [ion binding]; other site 502025012589 G-X-G motif; other site 502025012590 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012592 active site 502025012593 phosphorylation site [posttranslational modification] 502025012594 intermolecular recognition site; other site 502025012595 dimerization interface [polypeptide binding]; other site 502025012596 Protein of unknown function, DUF399; Region: DUF399; cl01139 502025012597 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 502025012598 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 502025012599 Permutation of conserved domain; other site 502025012600 active site 502025012601 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 502025012602 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 502025012603 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 502025012604 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 502025012605 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 502025012606 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 502025012607 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025012608 Protein phosphatase 2C; Region: PP2C; pfam00481 502025012609 active site 502025012610 SpoVR like protein; Region: SpoVR; pfam04293 502025012611 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 502025012612 hypothetical protein; Provisional; Region: PRK05325 502025012613 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 502025012614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 502025012615 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 502025012616 YceG-like family; Region: YceG; pfam02618 502025012617 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 502025012618 dimerization interface [polypeptide binding]; other site 502025012619 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 502025012620 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 502025012621 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 502025012622 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 502025012623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025012624 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 502025012625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025012626 DNA binding residues [nucleotide binding] 502025012627 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025012628 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 502025012629 active site 502025012630 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 502025012631 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 502025012632 HIGH motif; other site 502025012633 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 502025012634 active site 502025012635 KMSKS motif; other site 502025012636 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 502025012637 active site 502025012638 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 502025012639 oligomerisation interface [polypeptide binding]; other site 502025012640 mobile loop; other site 502025012641 roof hairpin; other site 502025012642 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025012643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012644 active site 502025012645 phosphorylation site [posttranslational modification] 502025012646 intermolecular recognition site; other site 502025012647 dimerization interface [polypeptide binding]; other site 502025012648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025012649 DNA binding site [nucleotide binding] 502025012650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025012651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012652 dimer interface [polypeptide binding]; other site 502025012653 phosphorylation site [posttranslational modification] 502025012654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012655 ATP binding site [chemical binding]; other site 502025012656 Mg2+ binding site [ion binding]; other site 502025012657 G-X-G motif; other site 502025012658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025012659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012660 dimer interface [polypeptide binding]; other site 502025012661 phosphorylation site [posttranslational modification] 502025012662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012663 ATP binding site [chemical binding]; other site 502025012664 Mg2+ binding site [ion binding]; other site 502025012665 G-X-G motif; other site 502025012666 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025012667 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025012668 P-loop; other site 502025012669 Magnesium ion binding site [ion binding]; other site 502025012670 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025012671 Magnesium ion binding site [ion binding]; other site 502025012672 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 502025012673 camphor resistance protein CrcB; Provisional; Region: PRK14195 502025012674 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 502025012675 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025012676 Methyltransferase domain; Region: Methyltransf_18; pfam12847 502025012677 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025012678 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025012679 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 502025012680 acyl-activating enzyme (AAE) consensus motif; other site 502025012681 acyl-activating enzyme (AAE) consensus motif; other site 502025012682 putative AMP binding site [chemical binding]; other site 502025012683 putative active site [active] 502025012684 putative CoA binding site [chemical binding]; other site 502025012685 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 502025012686 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 502025012687 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 502025012688 E-class dimer interface [polypeptide binding]; other site 502025012689 P-class dimer interface [polypeptide binding]; other site 502025012690 active site 502025012691 Cu2+ binding site [ion binding]; other site 502025012692 Zn2+ binding site [ion binding]; other site 502025012693 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 502025012694 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 502025012695 putative DNA binding site [nucleotide binding]; other site 502025012696 catalytic residue [active] 502025012697 putative H2TH interface [polypeptide binding]; other site 502025012698 putative catalytic residues [active] 502025012699 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 502025012700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025012701 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 502025012702 ATP binding site [chemical binding]; other site 502025012703 putative Mg++ binding site [ion binding]; other site 502025012704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025012705 nucleotide binding region [chemical binding]; other site 502025012706 ATP-binding site [chemical binding]; other site 502025012707 DEAD/H associated; Region: DEAD_assoc; pfam08494 502025012708 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025012709 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 502025012710 Uncharacterized conserved protein [Function unknown]; Region: COG1434 502025012711 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 502025012712 putative active site [active] 502025012713 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 502025012714 active site 502025012715 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025012716 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 502025012717 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012718 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025012719 active site 502025012720 ATP binding site [chemical binding]; other site 502025012721 substrate binding site [chemical binding]; other site 502025012722 activation loop (A-loop); other site 502025012723 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 502025012724 Double zinc ribbon; Region: DZR; pfam12773 502025012725 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 502025012726 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 502025012727 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 502025012728 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 502025012729 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 502025012730 putative homodimer interface [polypeptide binding]; other site 502025012731 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 502025012732 spermidine synthase; Provisional; Region: PRK00811 502025012733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025012734 S-adenosylmethionine binding site [chemical binding]; other site 502025012735 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 502025012736 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 502025012737 intersubunit interface [polypeptide binding]; other site 502025012738 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 502025012739 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025012740 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025012741 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025012742 phosphopeptide binding site; other site 502025012743 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025012744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012745 Walker A motif; other site 502025012746 ATP binding site [chemical binding]; other site 502025012747 Walker B motif; other site 502025012748 arginine finger; other site 502025012749 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 502025012750 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025012751 metal ion-dependent adhesion site (MIDAS); other site 502025012752 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025012753 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025012754 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 502025012755 Penicillinase repressor; Region: Pencillinase_R; cl17580 502025012756 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 502025012757 pyrroline-5-carboxylate reductase; Region: PLN02688 502025012758 Uncharacterized conserved protein [Function unknown]; Region: COG1872 502025012759 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 502025012760 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 502025012761 PilZ domain; Region: PilZ; cl01260 502025012762 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025012763 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 502025012764 GAF domain; Region: GAF; pfam01590 502025012765 Phytochrome region; Region: PHY; pfam00360 502025012766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012767 dimer interface [polypeptide binding]; other site 502025012768 phosphorylation site [posttranslational modification] 502025012769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012770 ATP binding site [chemical binding]; other site 502025012771 Mg2+ binding site [ion binding]; other site 502025012772 G-X-G motif; other site 502025012773 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025012774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012775 active site 502025012776 phosphorylation site [posttranslational modification] 502025012777 intermolecular recognition site; other site 502025012778 dimerization interface [polypeptide binding]; other site 502025012779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012780 active site 502025012781 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025012782 phosphorylation site [posttranslational modification] 502025012783 intermolecular recognition site; other site 502025012784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025012785 dimer interface [polypeptide binding]; other site 502025012786 phosphorylation site [posttranslational modification] 502025012787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025012788 ATP binding site [chemical binding]; other site 502025012789 Mg2+ binding site [ion binding]; other site 502025012790 G-X-G motif; other site 502025012791 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 502025012792 heme binding pocket [chemical binding]; other site 502025012793 heme ligand [chemical binding]; other site 502025012794 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 502025012795 DNA binding site [nucleotide binding] 502025012796 active site 502025012797 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 502025012798 MoaE interaction surface [polypeptide binding]; other site 502025012799 MoeB interaction surface [polypeptide binding]; other site 502025012800 thiocarboxylated glycine; other site 502025012801 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 502025012802 MoaE homodimer interface [polypeptide binding]; other site 502025012803 MoaD interaction [polypeptide binding]; other site 502025012804 active site residues [active] 502025012805 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 502025012806 phosphopeptide binding site; other site 502025012807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012808 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025012809 Walker A motif; other site 502025012810 ATP binding site [chemical binding]; other site 502025012811 Walker B motif; other site 502025012812 arginine finger; other site 502025012813 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 502025012814 FHA domain; Region: FHA; pfam00498 502025012815 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 502025012816 Zn binding site [ion binding]; other site 502025012817 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 502025012818 putative active site [active] 502025012819 putative CoA binding site [chemical binding]; other site 502025012820 nudix motif; other site 502025012821 metal binding site [ion binding]; metal-binding site 502025012822 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 502025012823 Citrate synthase; Region: Citrate_synt; pfam00285 502025012824 oxalacetate binding site [chemical binding]; other site 502025012825 citrylCoA binding site [chemical binding]; other site 502025012826 coenzyme A binding site [chemical binding]; other site 502025012827 catalytic triad [active] 502025012828 NRDE protein; Region: NRDE; cl01315 502025012829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025012830 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025012831 S-adenosylmethionine binding site [chemical binding]; other site 502025012832 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 502025012833 catalytic triad [active] 502025012834 putative active site [active] 502025012835 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025012836 Cytochrome P450; Region: p450; cl12078 502025012837 Protein of unknown function (DUF692); Region: DUF692; cl01263 502025012838 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 502025012839 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025012840 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025012841 catalytic residue [active] 502025012842 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 502025012843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 502025012844 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 502025012845 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 502025012846 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 502025012847 dimerization interface [polypeptide binding]; other site 502025012848 putative ATP binding site [chemical binding]; other site 502025012849 putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045 502025012850 Radical SAM superfamily; Region: Radical_SAM; pfam04055 502025012851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025012852 FeS/SAM binding site; other site 502025012853 Predicted amidohydrolase [General function prediction only]; Region: COG0388 502025012854 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 502025012855 putative active site [active] 502025012856 catalytic triad [active] 502025012857 putative dimer interface [polypeptide binding]; other site 502025012858 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 502025012859 GAF domain; Region: GAF; cl17456 502025012860 GAF domain; Region: GAF_2; pfam13185 502025012861 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025012862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025012863 Walker A motif; other site 502025012864 ATP binding site [chemical binding]; other site 502025012865 Walker B motif; other site 502025012866 arginine finger; other site 502025012867 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025012868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025012869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025012870 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 502025012871 dimer interface [polypeptide binding]; other site 502025012872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025012873 Major Facilitator Superfamily; Region: MFS_1; pfam07690 502025012874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025012875 putative substrate translocation pore; other site 502025012876 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 502025012877 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 502025012878 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 502025012879 active site 502025012880 dimer interface [polypeptide binding]; other site 502025012881 motif 1; other site 502025012882 motif 2; other site 502025012883 motif 3; other site 502025012884 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 502025012885 anticodon binding site; other site 502025012886 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025012887 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025012888 Endonuclease I; Region: Endonuclease_1; cl01003 502025012889 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 502025012890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025012891 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 502025012892 DNA binding residues [nucleotide binding] 502025012893 YCII-related domain; Region: YCII; cl00999 502025012894 Fatty acid desaturase; Region: FA_desaturase; pfam00487 502025012895 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 502025012896 putative di-iron ligands [ion binding]; other site 502025012897 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 502025012898 Family description; Region: VCBS; pfam13517 502025012899 Family description; Region: VCBS; pfam13517 502025012900 Family description; Region: VCBS; pfam13517 502025012901 Family description; Region: VCBS; pfam13517 502025012902 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 502025012903 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 502025012904 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 502025012905 iron-sulfur cluster [ion binding]; other site 502025012906 [2Fe-2S] cluster binding site [ion binding]; other site 502025012907 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 502025012908 GH3 auxin-responsive promoter; Region: GH3; pfam03321 502025012909 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 502025012910 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 502025012911 short chain dehydrogenase; Provisional; Region: PRK06924 502025012912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025012913 NAD(P) binding site [chemical binding]; other site 502025012914 active site 502025012915 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025012916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025012917 non-specific DNA binding site [nucleotide binding]; other site 502025012918 salt bridge; other site 502025012919 sequence-specific DNA binding site [nucleotide binding]; other site 502025012920 Cupin domain; Region: Cupin_2; pfam07883 502025012921 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025012922 PAAR motif; Region: PAAR_motif; pfam05488 502025012923 Carboxylesterase family; Region: COesterase; pfam00135 502025012924 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 502025012925 substrate binding pocket [chemical binding]; other site 502025012926 catalytic triad [active] 502025012927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025012928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025012929 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 502025012930 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 502025012931 NADP binding site [chemical binding]; other site 502025012932 dimer interface [polypeptide binding]; other site 502025012933 Predicted transcriptional regulators [Transcription]; Region: COG1733 502025012934 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 502025012935 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 502025012936 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 502025012937 dimer interface [polypeptide binding]; other site 502025012938 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 502025012939 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025012940 substrate binding site [chemical binding]; other site 502025012941 oxyanion hole (OAH) forming residues; other site 502025012942 trimer interface [polypeptide binding]; other site 502025012943 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 502025012944 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 502025012945 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 502025012946 FAD binding site [chemical binding]; other site 502025012947 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 502025012948 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 502025012949 active site 502025012950 dimer interface [polypeptide binding]; other site 502025012951 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 502025012952 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025012953 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 502025012954 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 502025012955 active site 502025012956 catalytic residues [active] 502025012957 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 502025012958 sugar binding site [chemical binding]; other site 502025012959 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 502025012960 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 502025012961 sugar binding site [chemical binding]; other site 502025012962 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 502025012963 sugar binding site [chemical binding]; other site 502025012964 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 502025012965 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 502025012966 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 502025012967 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 502025012968 sugar binding site [chemical binding]; other site 502025012969 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025012970 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025012971 active site 502025012972 ATP binding site [chemical binding]; other site 502025012973 substrate binding site [chemical binding]; other site 502025012974 activation loop (A-loop); other site 502025012975 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 502025012976 G1 box; other site 502025012977 GTP/Mg2+ binding site [chemical binding]; other site 502025012978 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025012979 WD domain, G-beta repeat; Region: WD40; pfam00400 502025012980 WD40 repeats; Region: WD40; smart00320 502025012981 WD domain, G-beta repeat; Region: WD40; pfam00400 502025012982 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025012983 structural tetrad; other site 502025012984 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025012985 structural tetrad; other site 502025012986 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025012987 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 502025012988 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025012989 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025012990 protein binding site [polypeptide binding]; other site 502025012991 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025012992 protein binding site [polypeptide binding]; other site 502025012993 Response regulator receiver domain; Region: Response_reg; pfam00072 502025012994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025012995 active site 502025012996 phosphorylation site [posttranslational modification] 502025012997 intermolecular recognition site; other site 502025012998 dimerization interface [polypeptide binding]; other site 502025012999 Found in ATP-dependent protease La (LON); Region: LON; smart00464 502025013000 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 502025013001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013002 Walker A motif; other site 502025013003 ATP binding site [chemical binding]; other site 502025013004 Walker B motif; other site 502025013005 arginine finger; other site 502025013006 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 502025013007 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 502025013008 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 502025013009 nucleotide binding site [chemical binding]; other site 502025013010 NEF interaction site [polypeptide binding]; other site 502025013011 SBD interface [polypeptide binding]; other site 502025013012 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 502025013013 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 502025013014 fumarate hydratase; Reviewed; Region: fumC; PRK00485 502025013015 Class II fumarases; Region: Fumarase_classII; cd01362 502025013016 active site 502025013017 tetramer interface [polypeptide binding]; other site 502025013018 Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248 502025013019 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013020 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013021 active site 502025013022 ATP binding site [chemical binding]; other site 502025013023 substrate binding site [chemical binding]; other site 502025013024 activation loop (A-loop); other site 502025013025 AAA ATPase domain; Region: AAA_16; pfam13191 502025013026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013027 TPR motif; other site 502025013028 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025013029 binding surface 502025013030 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025013031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013032 binding surface 502025013033 TPR motif; other site 502025013034 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025013035 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 502025013036 Histidine kinase; Region: His_kinase; pfam06580 502025013037 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 502025013038 ATP binding site [chemical binding]; other site 502025013039 Mg2+ binding site [ion binding]; other site 502025013040 G-X-G motif; other site 502025013041 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 502025013042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013043 active site 502025013044 phosphorylation site [posttranslational modification] 502025013045 intermolecular recognition site; other site 502025013046 dimerization interface [polypeptide binding]; other site 502025013047 LytTr DNA-binding domain; Region: LytTR; smart00850 502025013048 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025013049 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025013050 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025013051 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025013052 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025013053 TPR repeat; Region: TPR_11; pfam13414 502025013054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013055 binding surface 502025013056 TPR motif; other site 502025013057 PEGA domain; Region: PEGA; pfam08308 502025013058 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013059 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013060 active site 502025013061 ATP binding site [chemical binding]; other site 502025013062 substrate binding site [chemical binding]; other site 502025013063 activation loop (A-loop); other site 502025013064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 502025013065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 502025013066 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013068 active site 502025013069 phosphorylation site [posttranslational modification] 502025013070 intermolecular recognition site; other site 502025013071 dimerization interface [polypeptide binding]; other site 502025013072 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 502025013073 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 502025013074 putative dimer interface [polypeptide binding]; other site 502025013075 putative anticodon binding site; other site 502025013076 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 502025013077 homodimer interface [polypeptide binding]; other site 502025013078 motif 1; other site 502025013079 motif 2; other site 502025013080 active site 502025013081 motif 3; other site 502025013082 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025013083 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025013084 ligand binding site [chemical binding]; other site 502025013085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013086 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025013087 Walker A motif; other site 502025013088 ATP binding site [chemical binding]; other site 502025013089 Walker B motif; other site 502025013090 arginine finger; other site 502025013091 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 502025013092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013093 active site 502025013094 phosphorylation site [posttranslational modification] 502025013095 intermolecular recognition site; other site 502025013096 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025013097 metal ion-dependent adhesion site (MIDAS); other site 502025013098 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025013099 Ligand Binding Site [chemical binding]; other site 502025013100 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025013101 Ligand Binding Site [chemical binding]; other site 502025013102 BCCT family transporter; Region: BCCT; pfam02028 502025013103 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025013104 HSP70 interaction site [polypeptide binding]; other site 502025013105 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 502025013106 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 502025013107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025013108 FeS/SAM binding site; other site 502025013109 TRAM domain; Region: TRAM; pfam01938 502025013110 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 502025013111 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 502025013112 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 502025013113 amino acid transporter; Region: 2A0306; TIGR00909 502025013114 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 502025013115 active site 502025013116 phosphorylation site [posttranslational modification] 502025013117 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025013118 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025013119 putative active site [active] 502025013120 heme pocket [chemical binding]; other site 502025013121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013122 phosphorylation site [posttranslational modification] 502025013123 dimer interface [polypeptide binding]; other site 502025013124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013125 ATP binding site [chemical binding]; other site 502025013126 Mg2+ binding site [ion binding]; other site 502025013127 G-X-G motif; other site 502025013128 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 502025013129 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 502025013130 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 502025013131 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 502025013132 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 502025013133 Walker A motif; other site 502025013134 ATP binding site [chemical binding]; other site 502025013135 Walker B motif; other site 502025013136 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 502025013137 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025013138 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 502025013139 Walker A motif; other site 502025013140 ATP binding site [chemical binding]; other site 502025013141 Walker B motif; other site 502025013142 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 502025013143 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 502025013144 putative RNA binding site [nucleotide binding]; other site 502025013145 Methyltransferase domain; Region: Methyltransf_26; pfam13659 502025013146 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 502025013147 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 502025013148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025013149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025013150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 502025013151 dimerization interface [polypeptide binding]; other site 502025013152 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 502025013153 DctM-like transporters; Region: DctM; pfam06808 502025013154 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 502025013155 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 502025013156 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 502025013157 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 502025013158 Uncharacterized conserved protein [Function unknown]; Region: COG4850 502025013159 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 502025013160 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 502025013161 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 502025013162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025013163 putative active site [active] 502025013164 PAS fold; Region: PAS_3; pfam08447 502025013165 heme pocket [chemical binding]; other site 502025013166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025013167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013168 dimer interface [polypeptide binding]; other site 502025013169 phosphorylation site [posttranslational modification] 502025013170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013171 ATP binding site [chemical binding]; other site 502025013172 Mg2+ binding site [ion binding]; other site 502025013173 G-X-G motif; other site 502025013174 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013176 active site 502025013177 phosphorylation site [posttranslational modification] 502025013178 intermolecular recognition site; other site 502025013179 dimerization interface [polypeptide binding]; other site 502025013180 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 502025013181 MltA specific insert domain; Region: MltA; smart00925 502025013182 3D domain; Region: 3D; pfam06725 502025013183 Predicted transcriptional regulator [Transcription]; Region: COG2378 502025013184 HTH domain; Region: HTH_11; pfam08279 502025013185 WYL domain; Region: WYL; pfam13280 502025013186 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 502025013187 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 502025013188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 502025013189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 502025013190 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025013191 RNA binding site [nucleotide binding]; other site 502025013192 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 502025013193 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 502025013194 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 502025013195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013196 Walker A motif; other site 502025013197 ATP binding site [chemical binding]; other site 502025013198 Walker B motif; other site 502025013199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025013200 Integrase core domain; Region: rve; pfam00665 502025013201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013202 Walker A motif; other site 502025013203 ATP binding site [chemical binding]; other site 502025013204 Walker B motif; other site 502025013205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025013206 Integrase core domain; Region: rve; pfam00665 502025013207 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 502025013208 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 502025013209 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 502025013210 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025013211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025013212 putative active site [active] 502025013213 heme pocket [chemical binding]; other site 502025013214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013215 dimer interface [polypeptide binding]; other site 502025013216 phosphorylation site [posttranslational modification] 502025013217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013218 ATP binding site [chemical binding]; other site 502025013219 Mg2+ binding site [ion binding]; other site 502025013220 G-X-G motif; other site 502025013221 Outer membrane efflux protein; Region: OEP; pfam02321 502025013222 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025013223 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 502025013224 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025013225 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025013226 Protein export membrane protein; Region: SecD_SecF; cl14618 502025013227 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025013228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025013229 S-adenosylmethionine binding site [chemical binding]; other site 502025013230 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 502025013231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025013232 S-adenosylmethionine binding site [chemical binding]; other site 502025013233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 502025013234 DNA binding site [nucleotide binding] 502025013235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 502025013236 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 502025013237 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 502025013238 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 502025013239 PEGA domain; Region: PEGA; pfam08308 502025013240 PilZ domain; Region: PilZ; pfam07238 502025013241 SurA N-terminal domain; Region: SurA_N; pfam09312 502025013242 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 502025013243 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 502025013244 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 502025013245 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 502025013246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025013247 ATP binding site [chemical binding]; other site 502025013248 putative Mg++ binding site [ion binding]; other site 502025013249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025013250 nucleotide binding region [chemical binding]; other site 502025013251 ATP-binding site [chemical binding]; other site 502025013252 TRCF domain; Region: TRCF; pfam03461 502025013253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013254 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013255 active site 502025013256 ATP binding site [chemical binding]; other site 502025013257 substrate binding site [chemical binding]; other site 502025013258 activation loop (A-loop); other site 502025013259 Part of AAA domain; Region: AAA_19; pfam13245 502025013260 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 502025013261 Family description; Region: UvrD_C_2; pfam13538 502025013262 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 502025013263 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 502025013264 dimer interface [polypeptide binding]; other site 502025013265 acyl-activating enzyme (AAE) consensus motif; other site 502025013266 putative active site [active] 502025013267 AMP binding site [chemical binding]; other site 502025013268 putative CoA binding site [chemical binding]; other site 502025013269 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 502025013270 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 502025013271 putative active site [active] 502025013272 catalytic site [active] 502025013273 putative metal binding site [ion binding]; other site 502025013274 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 502025013275 homotrimer interaction site [polypeptide binding]; other site 502025013276 putative active site [active] 502025013277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025013278 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025013279 active site 502025013280 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 502025013281 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025013282 substrate binding site [chemical binding]; other site 502025013283 oxyanion hole (OAH) forming residues; other site 502025013284 trimer interface [polypeptide binding]; other site 502025013285 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025013286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013287 NAD(P) binding site [chemical binding]; other site 502025013288 active site 502025013289 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 502025013290 hypothetical protein; Provisional; Region: PRK07236 502025013291 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 502025013292 active site 502025013293 FMN binding site [chemical binding]; other site 502025013294 substrate binding site [chemical binding]; other site 502025013295 homotetramer interface [polypeptide binding]; other site 502025013296 catalytic residue [active] 502025013297 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 502025013298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025013299 FAD binding site [chemical binding]; other site 502025013300 substrate binding pocket [chemical binding]; other site 502025013301 catalytic base [active] 502025013302 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 502025013303 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 502025013304 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025013305 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025013306 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025013307 DNA binding residues [nucleotide binding] 502025013308 Uncharacterized conserved protein (DUF2361); Region: DUF2361; pfam10153 502025013309 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 502025013310 metal binding triad [ion binding]; metal-binding site 502025013311 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 502025013312 Phosphoesterase family; Region: Phosphoesterase; pfam04185 502025013313 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 502025013314 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 502025013315 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 502025013316 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025013317 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025013318 ligand binding site [chemical binding]; other site 502025013319 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 502025013320 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 502025013321 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 502025013322 putative NAD(P) binding site [chemical binding]; other site 502025013323 putative active site [active] 502025013324 bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Provisional; Region: PRK08961 502025013325 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013326 active site 502025013327 ATP binding site [chemical binding]; other site 502025013328 substrate binding site [chemical binding]; other site 502025013329 activation loop (A-loop); other site 502025013330 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013331 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013332 active site 502025013333 ATP binding site [chemical binding]; other site 502025013334 substrate binding site [chemical binding]; other site 502025013335 activation loop (A-loop); other site 502025013336 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 502025013337 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 502025013338 NAD binding site [chemical binding]; other site 502025013339 homotetramer interface [polypeptide binding]; other site 502025013340 homodimer interface [polypeptide binding]; other site 502025013341 substrate binding site [chemical binding]; other site 502025013342 active site 502025013343 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 502025013344 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 502025013345 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025013346 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025013347 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025013348 active site 502025013349 catalytic tetrad [active] 502025013350 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 502025013351 DNA binding residues [nucleotide binding] 502025013352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025013353 DNA binding residues [nucleotide binding] 502025013354 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025013355 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025013356 phosphopeptide binding site; other site 502025013357 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 502025013358 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 502025013359 purine monophosphate binding site [chemical binding]; other site 502025013360 dimer interface [polypeptide binding]; other site 502025013361 putative catalytic residues [active] 502025013362 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 502025013363 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 502025013364 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 502025013365 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 502025013366 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025013367 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 502025013368 AIR carboxylase; Region: AIRC; pfam00731 502025013369 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 502025013370 Uncharacterized conserved protein [Function unknown]; Region: COG4198 502025013371 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 502025013372 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 502025013373 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 502025013374 DNA-binding site [nucleotide binding]; DNA binding site 502025013375 RNA-binding motif; other site 502025013376 Stage II sporulation protein; Region: SpoIID; pfam08486 502025013377 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 502025013378 CAAX protease self-immunity; Region: Abi; pfam02517 502025013379 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 502025013380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025013381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025013382 DNA binding residues [nucleotide binding] 502025013383 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 502025013384 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025013385 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 502025013386 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 502025013387 active site 502025013388 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 502025013389 DNA binding site [nucleotide binding] 502025013390 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 502025013391 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 502025013392 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 502025013393 nucleotide binding site [chemical binding]; other site 502025013394 N-acetyl-L-glutamate binding site [chemical binding]; other site 502025013395 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 502025013396 TM2 domain; Region: TM2; pfam05154 502025013397 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 502025013398 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025013399 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025013400 DNA binding residues [nucleotide binding] 502025013401 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 502025013402 aldehyde dehydrogenase; Provisional; Region: PRK11903 502025013403 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025013404 NAD(P) binding site [chemical binding]; other site 502025013405 catalytic residues [active] 502025013406 aspartate kinase; Reviewed; Region: PRK06635 502025013407 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 502025013408 putative nucleotide binding site [chemical binding]; other site 502025013409 putative catalytic residues [active] 502025013410 putative Mg ion binding site [ion binding]; other site 502025013411 putative aspartate binding site [chemical binding]; other site 502025013412 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 502025013413 putative allosteric regulatory site; other site 502025013414 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 502025013415 putative allosteric regulatory residue; other site 502025013416 Uncharacterized conserved protein [Function unknown]; Region: COG1262 502025013417 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025013418 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 502025013419 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013421 active site 502025013422 phosphorylation site [posttranslational modification] 502025013423 intermolecular recognition site; other site 502025013424 dimerization interface [polypeptide binding]; other site 502025013425 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025013426 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 502025013427 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 502025013428 RNA binding surface [nucleotide binding]; other site 502025013429 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025013430 active site 502025013431 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 502025013432 tandem repeat interface [polypeptide binding]; other site 502025013433 oligomer interface [polypeptide binding]; other site 502025013434 active site residues [active] 502025013435 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 502025013436 tandem repeat interface [polypeptide binding]; other site 502025013437 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 502025013438 oligomer interface [polypeptide binding]; other site 502025013439 active site residues [active] 502025013440 GTP-binding protein YchF; Reviewed; Region: PRK09601 502025013441 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 502025013442 G1 box; other site 502025013443 GTP/Mg2+ binding site [chemical binding]; other site 502025013444 G2 box; other site 502025013445 Switch I region; other site 502025013446 G3 box; other site 502025013447 Switch II region; other site 502025013448 G4 box; other site 502025013449 G5 box; other site 502025013450 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 502025013451 SCP-2 sterol transfer family; Region: SCP2; pfam02036 502025013452 PEGA domain; Region: PEGA; pfam08308 502025013453 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013454 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013455 active site 502025013456 ATP binding site [chemical binding]; other site 502025013457 substrate binding site [chemical binding]; other site 502025013458 activation loop (A-loop); other site 502025013459 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013460 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013461 active site 502025013462 ATP binding site [chemical binding]; other site 502025013463 substrate binding site [chemical binding]; other site 502025013464 activation loop (A-loop); other site 502025013465 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025013466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013467 binding surface 502025013468 TPR motif; other site 502025013469 ribonuclease R; Region: RNase_R; TIGR02063 502025013470 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 502025013471 RNB domain; Region: RNB; pfam00773 502025013472 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 502025013473 RNA binding site [nucleotide binding]; other site 502025013474 FOG: WD40-like repeat [Function unknown]; Region: COG1520 502025013475 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 502025013476 Trp docking motif [polypeptide binding]; other site 502025013477 active site 502025013478 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025013479 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025013480 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 502025013481 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 502025013482 aspartate aminotransferase; Provisional; Region: PRK05764 502025013483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025013484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025013485 homodimer interface [polypeptide binding]; other site 502025013486 catalytic residue [active] 502025013487 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 502025013488 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 502025013489 active site 502025013490 (T/H)XGH motif; other site 502025013491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025013492 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 502025013493 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 502025013494 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025013495 acyl-activating enzyme (AAE) consensus motif; other site 502025013496 AMP binding site [chemical binding]; other site 502025013497 active site 502025013498 CoA binding site [chemical binding]; other site 502025013499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025013500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025013501 photolyase PhrII; Region: phr2; TIGR00591 502025013502 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 502025013503 dimer interface [polypeptide binding]; other site 502025013504 putative CheW interface [polypeptide binding]; other site 502025013505 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 502025013506 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025013507 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013508 active site 502025013509 ATP binding site [chemical binding]; other site 502025013510 substrate binding site [chemical binding]; other site 502025013511 activation loop (A-loop); other site 502025013512 cyclase homology domain; Region: CHD; cd07302 502025013513 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 502025013514 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 502025013515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025013516 ATP binding site [chemical binding]; other site 502025013517 putative Mg++ binding site [ion binding]; other site 502025013518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025013519 nucleotide binding region [chemical binding]; other site 502025013520 ATP-binding site [chemical binding]; other site 502025013521 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 502025013522 TPR repeat; Region: TPR_11; pfam13414 502025013523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013524 binding surface 502025013525 TPR motif; other site 502025013526 PEGA domain; Region: PEGA; pfam08308 502025013527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013528 TPR repeat; Region: TPR_11; pfam13414 502025013529 binding surface 502025013530 TPR motif; other site 502025013531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013532 TPR motif; other site 502025013533 binding surface 502025013534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013535 TPR motif; other site 502025013536 binding surface 502025013537 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 502025013538 putative trimer interface [polypeptide binding]; other site 502025013539 putative CoA binding site [chemical binding]; other site 502025013540 trigger factor; Region: tig; TIGR00115 502025013541 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 502025013542 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 502025013543 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 502025013544 oligomer interface [polypeptide binding]; other site 502025013545 active site residues [active] 502025013546 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 502025013547 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 502025013548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013549 Walker A motif; other site 502025013550 ATP binding site [chemical binding]; other site 502025013551 Walker B motif; other site 502025013552 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 502025013553 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 502025013554 Found in ATP-dependent protease La (LON); Region: LON; smart00464 502025013555 Found in ATP-dependent protease La (LON); Region: LON; smart00464 502025013556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013557 Walker A motif; other site 502025013558 ATP binding site [chemical binding]; other site 502025013559 Walker B motif; other site 502025013560 arginine finger; other site 502025013561 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 502025013562 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013563 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013564 active site 502025013565 ATP binding site [chemical binding]; other site 502025013566 substrate binding site [chemical binding]; other site 502025013567 activation loop (A-loop); other site 502025013568 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 502025013569 TrkA-C domain; Region: TrkA_C; pfam02080 502025013570 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 502025013571 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 502025013572 Major Facilitator Superfamily; Region: MFS_1; pfam07690 502025013573 muropeptide transporter; Validated; Region: ampG; cl17669 502025013574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025013575 AAA domain; Region: AAA_21; pfam13304 502025013576 Walker A/P-loop; other site 502025013577 ATP binding site [chemical binding]; other site 502025013578 AAA domain; Region: AAA_21; pfam13304 502025013579 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 502025013580 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 502025013581 TPP-binding site [chemical binding]; other site 502025013582 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 502025013583 dimer interface [polypeptide binding]; other site 502025013584 PYR/PP interface [polypeptide binding]; other site 502025013585 TPP binding site [chemical binding]; other site 502025013586 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 502025013587 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 502025013588 E3 interaction surface; other site 502025013589 lipoyl attachment site [posttranslational modification]; other site 502025013590 e3 binding domain; Region: E3_binding; pfam02817 502025013591 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 502025013592 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 502025013593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025013594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025013595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025013596 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 502025013597 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 502025013598 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 502025013599 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 502025013600 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025013601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025013602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013603 NAD(P) binding site [chemical binding]; other site 502025013604 active site 502025013605 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 502025013606 Clp amino terminal domain; Region: Clp_N; pfam02861 502025013607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013608 Walker A motif; other site 502025013609 ATP binding site [chemical binding]; other site 502025013610 Walker B motif; other site 502025013611 arginine finger; other site 502025013612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013613 Walker A motif; other site 502025013614 ATP binding site [chemical binding]; other site 502025013615 Walker B motif; other site 502025013616 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 502025013617 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 502025013618 OPT oligopeptide transporter protein; Region: OPT; pfam03169 502025013619 hypothetical protein; Provisional; Region: PRK07907 502025013620 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 502025013621 metal binding site [ion binding]; metal-binding site 502025013622 putative dimer interface [polypeptide binding]; other site 502025013623 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025013624 Ligand Binding Site [chemical binding]; other site 502025013625 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 502025013626 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 502025013627 HsdM N-terminal domain; Region: HsdM_N; pfam12161 502025013628 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 502025013629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025013630 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 502025013631 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 502025013632 Zn binding site [ion binding]; other site 502025013633 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 502025013634 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 502025013635 dimer interface [polypeptide binding]; other site 502025013636 motif 1; other site 502025013637 active site 502025013638 motif 2; other site 502025013639 motif 3; other site 502025013640 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 502025013641 anticodon binding site; other site 502025013642 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 502025013643 IHF - DNA interface [nucleotide binding]; other site 502025013644 IHF dimer interface [polypeptide binding]; other site 502025013645 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 502025013646 Fe-S cluster binding site [ion binding]; other site 502025013647 active site 502025013648 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 502025013649 Flavoprotein; Region: Flavoprotein; pfam02441 502025013650 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 502025013651 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 502025013652 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 502025013653 putative acyl-acceptor binding pocket; other site 502025013654 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025013655 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 502025013656 putative NAD(P) binding site [chemical binding]; other site 502025013657 active site 502025013658 putative substrate binding site [chemical binding]; other site 502025013659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 502025013660 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025013661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013662 Walker A motif; other site 502025013663 ATP binding site [chemical binding]; other site 502025013664 Walker B motif; other site 502025013665 arginine finger; other site 502025013666 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 502025013667 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 502025013668 Patatin-like phospholipase; Region: Patatin; pfam01734 502025013669 active site 502025013670 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 502025013671 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025013672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025013673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013674 ATP binding site [chemical binding]; other site 502025013675 G-X-G motif; other site 502025013676 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 502025013678 active site 502025013679 phosphorylation site [posttranslational modification] 502025013680 intermolecular recognition site; other site 502025013681 dimerization interface [polypeptide binding]; other site 502025013682 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025013683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025013684 NAD(P) binding site [chemical binding]; other site 502025013685 active site 502025013686 Lamin Tail Domain; Region: LTD; pfam00932 502025013687 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 502025013688 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 502025013689 generic binding surface I; other site 502025013690 generic binding surface II; other site 502025013691 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 502025013692 putative active site [active] 502025013693 putative catalytic site [active] 502025013694 putative Mg binding site IVb [ion binding]; other site 502025013695 putative phosphate binding site [ion binding]; other site 502025013696 putative DNA binding site [nucleotide binding]; other site 502025013697 putative Mg binding site IVa [ion binding]; other site 502025013698 BolA-like protein; Region: BolA; pfam01722 502025013699 GTPase RsgA; Reviewed; Region: PRK01889 502025013700 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025013701 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 502025013702 GTPase/Zn-binding domain interface [polypeptide binding]; other site 502025013703 GTP/Mg2+ binding site [chemical binding]; other site 502025013704 G4 box; other site 502025013705 G5 box; other site 502025013706 G1 box; other site 502025013707 Switch I region; other site 502025013708 G2 box; other site 502025013709 G3 box; other site 502025013710 Switch II region; other site 502025013711 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 502025013712 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 502025013713 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 502025013714 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 502025013715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 502025013716 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 502025013717 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 502025013718 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025013719 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025013720 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 502025013721 PA/protease or protease-like domain interface [polypeptide binding]; other site 502025013722 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 502025013723 Peptidase family M28; Region: Peptidase_M28; pfam04389 502025013724 metal binding site [ion binding]; metal-binding site 502025013725 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025013726 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 502025013727 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 502025013728 NADP binding site [chemical binding]; other site 502025013729 dimer interface [polypeptide binding]; other site 502025013730 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025013731 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 502025013732 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 502025013733 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 502025013734 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025013735 active site 502025013736 ATP binding site [chemical binding]; other site 502025013737 substrate binding site [chemical binding]; other site 502025013738 activation loop (A-loop); other site 502025013739 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 502025013740 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025013741 active site 502025013742 Cupin domain; Region: Cupin_2; cl17218 502025013743 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 502025013744 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 502025013745 active site 502025013746 substrate binding site [chemical binding]; other site 502025013747 metal binding site [ion binding]; metal-binding site 502025013748 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 502025013749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 502025013750 nucleotide binding site [chemical binding]; other site 502025013751 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025013752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013753 Walker A motif; other site 502025013754 ATP binding site [chemical binding]; other site 502025013755 Walker B motif; other site 502025013756 arginine finger; other site 502025013757 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025013758 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 502025013759 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 502025013760 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 502025013761 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013763 active site 502025013764 phosphorylation site [posttranslational modification] 502025013765 intermolecular recognition site; other site 502025013766 dimerization interface [polypeptide binding]; other site 502025013767 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 502025013768 nucleotidyl binding site; other site 502025013769 metal binding site [ion binding]; metal-binding site 502025013770 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 502025013771 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 502025013772 active site 502025013773 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025013774 short chain dehydrogenase; Provisional; Region: PRK07035 502025013775 classical (c) SDRs; Region: SDR_c; cd05233 502025013776 NAD(P) binding site [chemical binding]; other site 502025013777 active site 502025013778 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 502025013779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025013780 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025013781 active site 502025013782 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 502025013783 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 502025013784 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 502025013785 active site 502025013786 Zn binding site [ion binding]; other site 502025013787 isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461 502025013788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025013789 active site 502025013790 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025013791 active site 502025013792 Zn binding site [ion binding]; other site 502025013793 Protein required for attachment to host cells; Region: Host_attach; pfam10116 502025013794 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 502025013795 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 502025013796 GIY-YIG motif/motif A; other site 502025013797 active site 502025013798 catalytic site [active] 502025013799 putative DNA binding site [nucleotide binding]; other site 502025013800 metal binding site [ion binding]; metal-binding site 502025013801 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 502025013802 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 502025013803 RIP metalloprotease RseP; Region: TIGR00054 502025013804 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 502025013805 active site 502025013806 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 502025013807 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 502025013808 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025013809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025013810 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 502025013811 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 502025013812 Ligand binding site; other site 502025013813 Putative Catalytic site; other site 502025013814 DXD motif; other site 502025013815 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 502025013816 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 502025013817 dimer interface [polypeptide binding]; other site 502025013818 ssDNA binding site [nucleotide binding]; other site 502025013819 tetramer (dimer of dimers) interface [polypeptide binding]; other site 502025013820 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 502025013821 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 502025013822 NodB motif; other site 502025013823 active site 502025013824 catalytic site [active] 502025013825 metal binding site [ion binding]; metal-binding site 502025013826 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025013827 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025013828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 502025013829 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 502025013830 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025013831 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 502025013832 C-terminal domain interface [polypeptide binding]; other site 502025013833 GSH binding site (G-site) [chemical binding]; other site 502025013834 dimer interface [polypeptide binding]; other site 502025013835 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025013836 substrate binding pocket (H-site) [chemical binding]; other site 502025013837 N-terminal domain interface [polypeptide binding]; other site 502025013838 Cytochrome c; Region: Cytochrom_C; cl11414 502025013839 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 502025013840 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025013841 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025013842 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025013843 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025013844 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025013845 PAS domain; Region: PAS_9; pfam13426 502025013846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025013847 putative active site [active] 502025013848 heme pocket [chemical binding]; other site 502025013849 PAS fold; Region: PAS_4; pfam08448 502025013850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013851 dimer interface [polypeptide binding]; other site 502025013852 phosphorylation site [posttranslational modification] 502025013853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013854 ATP binding site [chemical binding]; other site 502025013855 Mg2+ binding site [ion binding]; other site 502025013856 G-X-G motif; other site 502025013857 tellurium resistance terB-like protein; Region: terB_like; cl11965 502025013858 metal binding site [ion binding]; metal-binding site 502025013859 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 502025013860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013861 Walker A motif; other site 502025013862 ATP binding site [chemical binding]; other site 502025013863 Walker B motif; other site 502025013864 arginine finger; other site 502025013865 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 502025013866 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 502025013867 NMT1/THI5 like; Region: NMT1; pfam09084 502025013868 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025013869 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025013870 ligand binding site [chemical binding]; other site 502025013871 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 502025013872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025013873 dimer interface [polypeptide binding]; other site 502025013874 conserved gate region; other site 502025013875 putative PBP binding loops; other site 502025013876 ABC-ATPase subunit interface; other site 502025013877 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 502025013878 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 502025013879 Walker A/P-loop; other site 502025013880 ATP binding site [chemical binding]; other site 502025013881 Q-loop/lid; other site 502025013882 ABC transporter signature motif; other site 502025013883 Walker B; other site 502025013884 D-loop; other site 502025013885 H-loop/switch region; other site 502025013886 Protein of unknown function (DUF419); Region: DUF419; pfam04237 502025013887 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 502025013888 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025013889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025013890 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025013891 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025013892 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 502025013893 acyl-activating enzyme (AAE) consensus motif; other site 502025013894 AMP binding site [chemical binding]; other site 502025013895 active site 502025013896 CoA binding site [chemical binding]; other site 502025013897 Creatinine amidohydrolase; Region: Creatininase; pfam02633 502025013898 sulfotransferase; Region: PLN02164 502025013899 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 502025013900 Cation transport protein; Region: TrkH; cl17365 502025013901 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 502025013902 TrkA-N domain; Region: TrkA_N; pfam02254 502025013903 TrkA-N domain; Region: TrkA_N; pfam02254 502025013904 TrkA-C domain; Region: TrkA_C; pfam02080 502025013905 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 502025013906 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 502025013907 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 502025013908 putative dimer interface [polypeptide binding]; other site 502025013909 N-terminal domain interface [polypeptide binding]; other site 502025013910 putative substrate binding pocket (H-site) [chemical binding]; other site 502025013911 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 502025013912 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025013913 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025013914 catalytic residue [active] 502025013915 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 502025013916 Cysteine-rich domain; Region: CCG; pfam02754 502025013917 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013918 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025013919 active site 502025013920 ATP binding site [chemical binding]; other site 502025013921 substrate binding site [chemical binding]; other site 502025013922 activation loop (A-loop); other site 502025013923 PEGA domain; Region: PEGA; pfam08308 502025013924 PEGA domain; Region: PEGA; pfam08308 502025013925 PEGA domain; Region: PEGA; pfam08308 502025013926 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025013927 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025013928 active site 502025013929 ATP binding site [chemical binding]; other site 502025013930 substrate binding site [chemical binding]; other site 502025013931 activation loop (A-loop); other site 502025013932 PEGA domain; Region: PEGA; pfam08308 502025013933 PEGA domain; Region: PEGA; pfam08308 502025013934 Tetratricopeptide repeat; Region: TPR_9; pfam13371 502025013935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013936 TPR motif; other site 502025013937 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 502025013938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025013939 active site 502025013940 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025013941 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025013942 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025013943 phosphopeptide binding site; other site 502025013944 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025013945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025013946 Walker A motif; other site 502025013947 ATP binding site [chemical binding]; other site 502025013948 Walker B motif; other site 502025013949 arginine finger; other site 502025013950 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025013951 TPR repeat; Region: TPR_11; pfam13414 502025013952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013953 binding surface 502025013954 TPR motif; other site 502025013955 TPR repeat; Region: TPR_11; pfam13414 502025013956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013957 binding surface 502025013958 TPR motif; other site 502025013959 TPR repeat; Region: TPR_11; pfam13414 502025013960 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025013961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025013962 binding surface 502025013963 TPR motif; other site 502025013964 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 502025013965 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025013966 putative catalytic residues [active] 502025013967 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 502025013968 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 502025013969 muropeptide transporter; Validated; Region: ampG; cl17669 502025013970 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 502025013971 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025013972 Ligand Binding Site [chemical binding]; other site 502025013973 Cna protein B-type domain; Region: Cna_B_2; pfam13715 502025013974 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 502025013975 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025013976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025013977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013978 dimer interface [polypeptide binding]; other site 502025013979 phosphorylation site [posttranslational modification] 502025013980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013981 ATP binding site [chemical binding]; other site 502025013982 Mg2+ binding site [ion binding]; other site 502025013983 G-X-G motif; other site 502025013984 Response regulator receiver domain; Region: Response_reg; pfam00072 502025013985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025013986 active site 502025013987 phosphorylation site [posttranslational modification] 502025013988 intermolecular recognition site; other site 502025013989 dimerization interface [polypeptide binding]; other site 502025013990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025013991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025013992 dimer interface [polypeptide binding]; other site 502025013993 phosphorylation site [posttranslational modification] 502025013994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025013995 ATP binding site [chemical binding]; other site 502025013996 Mg2+ binding site [ion binding]; other site 502025013997 G-X-G motif; other site 502025013998 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 502025013999 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 502025014000 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 502025014001 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 502025014002 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14668 502025014003 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 502025014004 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025014005 metal ion-dependent adhesion site (MIDAS); other site 502025014006 PilZ domain; Region: PilZ; cl01260 502025014007 PEGA domain; Region: PEGA; pfam08308 502025014008 PEGA domain; Region: PEGA; pfam08308 502025014009 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 502025014010 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 502025014011 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 502025014012 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 502025014013 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 502025014014 catalytic triad [active] 502025014015 dimer interface [polypeptide binding]; other site 502025014016 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 502025014017 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 502025014018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025014019 catalytic residue [active] 502025014020 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 502025014021 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 502025014022 substrate binding site [chemical binding]; other site 502025014023 active site 502025014024 catalytic residues [active] 502025014025 heterodimer interface [polypeptide binding]; other site 502025014026 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 502025014027 Predicted membrane protein [Function unknown]; Region: COG4325 502025014028 Predicted metalloprotease [General function prediction only]; Region: COG2321 502025014029 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 502025014030 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025014031 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025014032 ligand binding site [chemical binding]; other site 502025014033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025014034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025014035 active site 502025014036 catalytic tetrad [active] 502025014037 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 502025014038 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 502025014039 putative NAD(P) binding site [chemical binding]; other site 502025014040 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 502025014041 ArsC family; Region: ArsC; pfam03960 502025014042 putative ArsC-like catalytic residues; other site 502025014043 putative TRX-like catalytic residues [active] 502025014044 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 502025014045 AAA domain; Region: AAA_30; pfam13604 502025014046 Family description; Region: UvrD_C_2; pfam13538 502025014047 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 502025014048 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025014049 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 502025014050 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 502025014051 dimerization interface 3.5A [polypeptide binding]; other site 502025014052 active site 502025014053 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 502025014054 putative binding surface; other site 502025014055 active site 502025014056 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014058 active site 502025014059 phosphorylation site [posttranslational modification] 502025014060 intermolecular recognition site; other site 502025014061 dimerization interface [polypeptide binding]; other site 502025014062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014063 dimer interface [polypeptide binding]; other site 502025014064 phosphorylation site [posttranslational modification] 502025014065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014066 ATP binding site [chemical binding]; other site 502025014067 Mg2+ binding site [ion binding]; other site 502025014068 G-X-G motif; other site 502025014069 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014071 active site 502025014072 phosphorylation site [posttranslational modification] 502025014073 intermolecular recognition site; other site 502025014074 dimerization interface [polypeptide binding]; other site 502025014075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025014076 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 502025014077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025014078 catalytic residue [active] 502025014079 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 502025014080 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 502025014081 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 502025014082 CoA-ligase; Region: Ligase_CoA; pfam00549 502025014083 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 502025014084 CoA binding domain; Region: CoA_binding; pfam02629 502025014085 CoA-ligase; Region: Ligase_CoA; pfam00549 502025014086 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 502025014087 active site 502025014088 multimer interface [polypeptide binding]; other site 502025014089 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 502025014090 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 502025014091 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025014092 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 502025014093 active site 502025014094 catalytic site [active] 502025014095 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 502025014096 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 502025014097 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 502025014098 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 502025014099 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025014100 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 502025014101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025014102 dimer interface [polypeptide binding]; other site 502025014103 conserved gate region; other site 502025014104 putative PBP binding loops; other site 502025014105 ABC-ATPase subunit interface; other site 502025014106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 502025014107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025014108 dimer interface [polypeptide binding]; other site 502025014109 conserved gate region; other site 502025014110 putative PBP binding loops; other site 502025014111 ABC-ATPase subunit interface; other site 502025014112 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 502025014113 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 502025014114 Walker A/P-loop; other site 502025014115 ATP binding site [chemical binding]; other site 502025014116 Q-loop/lid; other site 502025014117 ABC transporter signature motif; other site 502025014118 Walker B; other site 502025014119 D-loop; other site 502025014120 H-loop/switch region; other site 502025014121 TOBE domain; Region: TOBE_2; pfam08402 502025014122 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 502025014123 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 502025014124 active site 502025014125 catalytic site [active] 502025014126 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 502025014127 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014129 active site 502025014130 phosphorylation site [posttranslational modification] 502025014131 intermolecular recognition site; other site 502025014132 dimerization interface [polypeptide binding]; other site 502025014133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025014134 non-specific DNA binding site [nucleotide binding]; other site 502025014135 salt bridge; other site 502025014136 sequence-specific DNA binding site [nucleotide binding]; other site 502025014137 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 502025014138 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 502025014139 4Fe-4S binding domain; Region: Fer4; pfam00037 502025014140 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 502025014141 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025014142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014143 active site 502025014144 phosphorylation site [posttranslational modification] 502025014145 intermolecular recognition site; other site 502025014146 dimerization interface [polypeptide binding]; other site 502025014147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014148 ATP binding site [chemical binding]; other site 502025014149 G-X-G motif; other site 502025014150 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014152 active site 502025014153 phosphorylation site [posttranslational modification] 502025014154 intermolecular recognition site; other site 502025014155 dimerization interface [polypeptide binding]; other site 502025014156 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 502025014157 Amidinotransferase; Region: Amidinotransf; cl12043 502025014158 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 502025014159 classical (c) SDRs; Region: SDR_c; cd05233 502025014160 NAD(P) binding site [chemical binding]; other site 502025014161 active site 502025014162 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025014163 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025014164 catalytic residues [active] 502025014165 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 502025014166 5'-3' exonuclease; Region: 53EXOc; smart00475 502025014167 active site 502025014168 metal binding site 1 [ion binding]; metal-binding site 502025014169 putative 5' ssDNA interaction site; other site 502025014170 metal binding site 3; metal-binding site 502025014171 metal binding site 2 [ion binding]; metal-binding site 502025014172 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 502025014173 putative DNA binding site [nucleotide binding]; other site 502025014174 putative metal binding site [ion binding]; other site 502025014175 Predicted esterase [General function prediction only]; Region: COG0400 502025014176 putative hydrolase; Provisional; Region: PRK11460 502025014177 Surface antigen; Region: Bac_surface_Ag; pfam01103 502025014178 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 502025014179 heme-binding site [chemical binding]; other site 502025014180 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 502025014181 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 502025014182 NAD(P) binding site [chemical binding]; other site 502025014183 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 502025014184 active site 502025014185 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025014186 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 502025014187 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025014188 active site 502025014189 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025014190 PBP superfamily domain; Region: PBP_like_2; cl17296 502025014191 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 502025014192 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 502025014193 catalytic site [active] 502025014194 putative active site [active] 502025014195 putative substrate binding site [chemical binding]; other site 502025014196 dimer interface [polypeptide binding]; other site 502025014197 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 502025014198 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 502025014199 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 502025014200 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 502025014201 TrkA-N domain; Region: TrkA_N; pfam02254 502025014202 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 502025014203 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 502025014204 active site 2 [active] 502025014205 active site 1 [active] 502025014206 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 502025014207 PHB binding site; other site 502025014208 CoenzymeA binding site [chemical binding]; other site 502025014209 subunit interaction site [polypeptide binding]; other site 502025014210 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; pfam02943 502025014211 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014212 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014213 active site 502025014214 ATP binding site [chemical binding]; other site 502025014215 substrate binding site [chemical binding]; other site 502025014216 activation loop (A-loop); other site 502025014217 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 502025014218 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 502025014219 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 502025014220 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025014221 substrate binding site [chemical binding]; other site 502025014222 oxyanion hole (OAH) forming residues; other site 502025014223 trimer interface [polypeptide binding]; other site 502025014224 SnoaL-like domain; Region: SnoaL_3; pfam13474 502025014225 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 502025014226 metal-binding site 502025014227 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 502025014228 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 502025014229 XdhC Rossmann domain; Region: XdhC_C; pfam13478 502025014230 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 502025014231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 502025014232 active site 502025014233 motif I; other site 502025014234 motif II; other site 502025014235 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025014236 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 502025014237 NADP binding site [chemical binding]; other site 502025014238 homodimer interface [polypeptide binding]; other site 502025014239 active site 502025014240 substrate binding site [chemical binding]; other site 502025014241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025014242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025014243 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 502025014244 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 502025014245 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025014246 active site 502025014247 Zn binding site [ion binding]; other site 502025014248 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 502025014249 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 502025014250 Walker A/P-loop; other site 502025014251 ATP binding site [chemical binding]; other site 502025014252 Q-loop/lid; other site 502025014253 ABC transporter signature motif; other site 502025014254 Walker B; other site 502025014255 D-loop; other site 502025014256 H-loop/switch region; other site 502025014257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025014258 dimer interface [polypeptide binding]; other site 502025014259 conserved gate region; other site 502025014260 putative PBP binding loops; other site 502025014261 ABC-ATPase subunit interface; other site 502025014262 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 502025014263 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 502025014264 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 502025014265 Double zinc ribbon; Region: DZR; pfam12773 502025014266 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 502025014267 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 502025014268 active site 502025014269 DNA binding site [nucleotide binding] 502025014270 Int/Topo IB signature motif; other site 502025014271 catalytic residues [active] 502025014272 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 502025014273 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 502025014274 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 502025014275 NAD binding site [chemical binding]; other site 502025014276 substrate binding site [chemical binding]; other site 502025014277 homodimer interface [polypeptide binding]; other site 502025014278 active site 502025014279 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025014280 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 502025014281 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 502025014282 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 502025014283 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 502025014284 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 502025014285 nucleotide binding site [chemical binding]; other site 502025014286 SulA interaction site; other site 502025014287 cell division protein FtsA; Region: ftsA; TIGR01174 502025014288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 502025014289 nucleotide binding site [chemical binding]; other site 502025014290 Cell division protein FtsA; Region: FtsA; pfam14450 502025014291 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 502025014292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 502025014293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014294 active site 502025014295 phosphorylation site [posttranslational modification] 502025014296 intermolecular recognition site; other site 502025014297 quinolinate synthetase; Provisional; Region: PRK09375 502025014298 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 502025014299 ThiC-associated domain; Region: ThiC-associated; pfam13667 502025014300 ThiC family; Region: ThiC; pfam01964 502025014301 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 502025014302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025014303 substrate binding site [chemical binding]; other site 502025014304 oxyanion hole (OAH) forming residues; other site 502025014305 trimer interface [polypeptide binding]; other site 502025014306 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 502025014307 substrate binding site [chemical binding]; other site 502025014308 oxyanion hole (OAH) forming residues; other site 502025014309 trimer interface [polypeptide binding]; other site 502025014310 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 502025014311 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025014312 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025014313 ligand binding site [chemical binding]; other site 502025014314 PEGA domain; Region: PEGA; pfam08308 502025014315 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 502025014316 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 502025014317 putative active site [active] 502025014318 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025014319 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 502025014320 NAD(P) binding site [chemical binding]; other site 502025014321 catalytic residues [active] 502025014322 methionine sulfoxide reductase B; Provisional; Region: PRK00222 502025014323 SelR domain; Region: SelR; pfam01641 502025014324 Protein of unknown function (DUF962); Region: DUF962; pfam06127 502025014325 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 502025014326 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025014327 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025014328 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 502025014329 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 502025014330 putative acyl-acceptor binding pocket; other site 502025014331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025014332 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 502025014333 putative NAD(P) binding site [chemical binding]; other site 502025014334 active site 502025014335 putative substrate binding site [chemical binding]; other site 502025014336 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 502025014337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 502025014338 ATP binding site [chemical binding]; other site 502025014339 putative Mg++ binding site [ion binding]; other site 502025014340 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 502025014341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 502025014342 nucleotide binding region [chemical binding]; other site 502025014343 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 502025014344 SEC-C motif; Region: SEC-C; pfam02810 502025014345 NACHT domain; Region: NACHT; pfam05729 502025014346 AlkA N-terminal domain; Region: AlkA_N; cl05528 502025014347 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 502025014348 Ubiquitin-like proteins; Region: UBQ; cl00155 502025014349 charged pocket; other site 502025014350 hydrophobic patch; other site 502025014351 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 502025014352 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 502025014353 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 502025014354 TonB C terminal; Region: TonB_2; pfam13103 502025014355 OsmC-like protein; Region: OsmC; pfam02566 502025014356 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 502025014357 putative ADP-ribose binding site [chemical binding]; other site 502025014358 putative active site [active] 502025014359 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 502025014360 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 502025014361 active site 502025014362 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 502025014363 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 502025014364 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 502025014365 Cupin domain; Region: Cupin_2; pfam07883 502025014366 CheB methylesterase; Region: CheB_methylest; pfam01339 502025014367 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 502025014368 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025014369 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 502025014370 PAS domain; Region: PAS_10; pfam13596 502025014371 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025014372 GAF domain; Region: GAF; pfam01590 502025014373 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025014374 GAF domain; Region: GAF_2; pfam13185 502025014375 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025014376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025014377 putative active site [active] 502025014378 heme pocket [chemical binding]; other site 502025014379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014380 dimer interface [polypeptide binding]; other site 502025014381 phosphorylation site [posttranslational modification] 502025014382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014383 ATP binding site [chemical binding]; other site 502025014384 Mg2+ binding site [ion binding]; other site 502025014385 G-X-G motif; other site 502025014386 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014388 active site 502025014389 phosphorylation site [posttranslational modification] 502025014390 intermolecular recognition site; other site 502025014391 dimerization interface [polypeptide binding]; other site 502025014392 CheB methylesterase; Region: CheB_methylest; pfam01339 502025014393 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025014394 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025014395 ligand binding site [chemical binding]; other site 502025014396 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 502025014397 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 502025014398 putative active site [active] 502025014399 catalytic site [active] 502025014400 putative metal binding site [ion binding]; other site 502025014401 Bacterial sugar transferase; Region: Bac_transf; pfam02397 502025014402 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025014403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025014404 Walker A motif; other site 502025014405 ATP binding site [chemical binding]; other site 502025014406 Walker B motif; other site 502025014407 arginine finger; other site 502025014408 short chain dehydrogenase; Provisional; Region: PRK08278 502025014409 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 502025014410 NAD(P) binding site [chemical binding]; other site 502025014411 homodimer interface [polypeptide binding]; other site 502025014412 active site 502025014413 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 502025014414 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 502025014415 NAD(P) binding site [chemical binding]; other site 502025014416 catalytic residues [active] 502025014417 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 502025014418 Putative esterase; Region: Esterase; pfam00756 502025014419 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 502025014420 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 502025014421 Family of unknown function (DUF490); Region: DUF490; pfam04357 502025014422 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 502025014423 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 502025014424 Surface antigen; Region: Bac_surface_Ag; pfam01103 502025014425 D-cysteine desulfhydrase; Validated; Region: PRK03910 502025014426 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 502025014427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025014428 catalytic residue [active] 502025014429 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 502025014430 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 502025014431 putative active site pocket [active] 502025014432 dimerization interface [polypeptide binding]; other site 502025014433 putative catalytic residue [active] 502025014434 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 502025014435 dimer interface [polypeptide binding]; other site 502025014436 catalytic triad [active] 502025014437 peroxidatic and resolving cysteines [active] 502025014438 Uncharacterized conserved protein [Function unknown]; Region: COG0327 502025014439 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 502025014440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 502025014441 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 502025014442 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 502025014443 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025014444 metal binding site [ion binding]; metal-binding site 502025014445 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 502025014446 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 502025014447 trimer interface [polypeptide binding]; other site 502025014448 active site 502025014449 substrate binding site [chemical binding]; other site 502025014450 CoA binding site [chemical binding]; other site 502025014451 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 502025014452 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025014453 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 502025014454 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025014455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014456 dimer interface [polypeptide binding]; other site 502025014457 phosphorylation site [posttranslational modification] 502025014458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014459 ATP binding site [chemical binding]; other site 502025014460 Mg2+ binding site [ion binding]; other site 502025014461 G-X-G motif; other site 502025014462 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025014463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014464 active site 502025014465 phosphorylation site [posttranslational modification] 502025014466 intermolecular recognition site; other site 502025014467 dimerization interface [polypeptide binding]; other site 502025014468 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014470 active site 502025014471 phosphorylation site [posttranslational modification] 502025014472 intermolecular recognition site; other site 502025014473 dimerization interface [polypeptide binding]; other site 502025014474 oxidative damage protection protein; Provisional; Region: PRK05408 502025014475 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 502025014476 putative active site [active] 502025014477 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025014478 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025014479 phosphopeptide binding site; other site 502025014480 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 502025014481 DNA binding site [nucleotide binding] 502025014482 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 502025014483 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 502025014484 FAD binding pocket [chemical binding]; other site 502025014485 conserved FAD binding motif [chemical binding]; other site 502025014486 phosphate binding motif [ion binding]; other site 502025014487 beta-alpha-beta structure motif; other site 502025014488 NAD binding pocket [chemical binding]; other site 502025014489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025014490 dimerization interface [polypeptide binding]; other site 502025014491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014492 dimer interface [polypeptide binding]; other site 502025014493 phosphorylation site [posttranslational modification] 502025014494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014495 ATP binding site [chemical binding]; other site 502025014496 Mg2+ binding site [ion binding]; other site 502025014497 G-X-G motif; other site 502025014498 Periplasmic binding protein domain; Region: Peripla_BP_5; pfam13433 502025014499 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 502025014500 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 502025014501 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 502025014502 putative catalytic residue [active] 502025014503 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 502025014504 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025014505 GTPase RsgA; Reviewed; Region: PRK01889 502025014506 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 502025014507 RNA binding site [nucleotide binding]; other site 502025014508 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 502025014509 GTPase/Zn-binding domain interface [polypeptide binding]; other site 502025014510 GTP/Mg2+ binding site [chemical binding]; other site 502025014511 G4 box; other site 502025014512 G5 box; other site 502025014513 G1 box; other site 502025014514 Switch I region; other site 502025014515 G2 box; other site 502025014516 G3 box; other site 502025014517 Switch II region; other site 502025014518 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 502025014519 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025014520 dimer interface [polypeptide binding]; other site 502025014521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025014522 catalytic residue [active] 502025014523 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 502025014524 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 502025014525 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 502025014526 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 502025014527 substrate binding pocket [chemical binding]; other site 502025014528 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 502025014529 B12 binding site [chemical binding]; other site 502025014530 cobalt ligand [ion binding]; other site 502025014531 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 502025014532 acetolactate synthase; Reviewed; Region: PRK08322 502025014533 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 502025014534 PYR/PP interface [polypeptide binding]; other site 502025014535 dimer interface [polypeptide binding]; other site 502025014536 TPP binding site [chemical binding]; other site 502025014537 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 502025014538 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 502025014539 TPP-binding site [chemical binding]; other site 502025014540 dimer interface [polypeptide binding]; other site 502025014541 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 502025014542 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 502025014543 NAD(P) binding site [chemical binding]; other site 502025014544 catalytic residues [active] 502025014545 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 502025014546 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 502025014547 active site 502025014548 homodimer interface [polypeptide binding]; other site 502025014549 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 502025014550 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025014551 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025014552 structural tetrad; other site 502025014553 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 502025014554 C-terminal peptidase (prc); Region: prc; TIGR00225 502025014555 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 502025014556 protein binding site [polypeptide binding]; other site 502025014557 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 502025014558 Domain interface; other site 502025014559 Peptide binding site; other site 502025014560 Active site tetrad [active] 502025014561 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025014562 active site 502025014563 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025014564 catalytic tetrad [active] 502025014565 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 502025014566 Glycoprotease family; Region: Peptidase_M22; pfam00814 502025014567 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 502025014568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014569 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014570 active site 502025014571 ATP binding site [chemical binding]; other site 502025014572 substrate binding site [chemical binding]; other site 502025014573 activation loop (A-loop); other site 502025014574 TPR repeat; Region: TPR_11; pfam13414 502025014575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014576 binding surface 502025014577 TPR motif; other site 502025014578 PEGA domain; Region: PEGA; pfam08308 502025014579 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 502025014580 catalytic residues [active] 502025014581 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014582 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014583 active site 502025014584 ATP binding site [chemical binding]; other site 502025014585 substrate binding site [chemical binding]; other site 502025014586 activation loop (A-loop); other site 502025014587 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 502025014588 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025014589 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025014590 putative catalytic site [active] 502025014591 putative metal binding site [ion binding]; other site 502025014592 putative phosphate binding site [ion binding]; other site 502025014593 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 502025014594 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 502025014595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025014596 Walker A/P-loop; other site 502025014597 ATP binding site [chemical binding]; other site 502025014598 Q-loop/lid; other site 502025014599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 502025014600 ABC transporter; Region: ABC_tran_2; pfam12848 502025014601 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 502025014602 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 502025014603 Peptidase family M50; Region: Peptidase_M50; pfam02163 502025014604 active site 502025014605 putative substrate binding region [chemical binding]; other site 502025014606 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025014607 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025014608 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 502025014609 active site 502025014610 catalytic triad [active] 502025014611 calcium binding site 1 [ion binding]; other site 502025014612 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 502025014613 rRNA interaction site [nucleotide binding]; other site 502025014614 S8 interaction site; other site 502025014615 putative laminin-1 binding site; other site 502025014616 elongation factor Ts; Reviewed; Region: tsf; PRK12332 502025014617 UBA/TS-N domain; Region: UBA; pfam00627 502025014618 Elongation factor TS; Region: EF_TS; pfam00889 502025014619 ribosome recycling factor; Reviewed; Region: frr; PRK00083 502025014620 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 502025014621 hinge region; other site 502025014622 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014623 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014624 active site 502025014625 ATP binding site [chemical binding]; other site 502025014626 substrate binding site [chemical binding]; other site 502025014627 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025014628 substrate binding site [chemical binding]; other site 502025014629 activation loop (A-loop); other site 502025014630 activation loop (A-loop); other site 502025014631 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 502025014632 putative active site [active] 502025014633 dimerization interface [polypeptide binding]; other site 502025014634 putative tRNAtyr binding site [nucleotide binding]; other site 502025014635 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 502025014636 Predicted methyltransferase [General function prediction only]; Region: COG4798 502025014637 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025014638 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 502025014639 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 502025014640 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 502025014641 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 502025014642 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014643 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014644 active site 502025014645 ATP binding site [chemical binding]; other site 502025014646 substrate binding site [chemical binding]; other site 502025014647 activation loop (A-loop); other site 502025014648 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 502025014649 dimer interface [polypeptide binding]; other site 502025014650 substrate binding site [chemical binding]; other site 502025014651 metal binding site [ion binding]; metal-binding site 502025014652 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 502025014653 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 502025014654 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 502025014655 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 502025014656 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025014657 active site 502025014658 Surface antigen; Region: Bac_surface_Ag; pfam01103 502025014659 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 502025014660 putative active site [active] 502025014661 Zn binding site [ion binding]; other site 502025014662 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025014663 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 502025014664 catalytic triad [active] 502025014665 putative active site [active] 502025014666 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 502025014667 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 502025014668 putative active site pocket [active] 502025014669 dimerization interface [polypeptide binding]; other site 502025014670 putative catalytic residue [active] 502025014671 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025014672 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025014673 active site 502025014674 catalytic tetrad [active] 502025014675 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014676 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014677 active site 502025014678 ATP binding site [chemical binding]; other site 502025014679 substrate binding site [chemical binding]; other site 502025014680 activation loop (A-loop); other site 502025014681 AAA ATPase domain; Region: AAA_16; pfam13191 502025014682 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025014683 structural tetrad; other site 502025014684 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025014685 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025014686 structural tetrad; other site 502025014687 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025014688 structural tetrad; other site 502025014689 WD40 repeats; Region: WD40; smart00320 502025014690 CoA binding domain; Region: CoA_binding; cl17356 502025014691 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 502025014692 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 502025014693 putative [4Fe-4S] binding site [ion binding]; other site 502025014694 putative molybdopterin cofactor binding site [chemical binding]; other site 502025014695 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 502025014696 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 502025014697 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025014698 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025014699 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025014700 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025014701 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025014702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014703 active site 502025014704 phosphorylation site [posttranslational modification] 502025014705 intermolecular recognition site; other site 502025014706 dimerization interface [polypeptide binding]; other site 502025014707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025014708 Walker A motif; other site 502025014709 ATP binding site [chemical binding]; other site 502025014710 Walker B motif; other site 502025014711 arginine finger; other site 502025014712 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025014713 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 502025014714 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 502025014715 hexamer interface [polypeptide binding]; other site 502025014716 ligand binding site [chemical binding]; other site 502025014717 putative active site [active] 502025014718 NAD(P) binding site [chemical binding]; other site 502025014719 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 502025014720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025014721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025014722 DNA binding residues [nucleotide binding] 502025014723 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 502025014724 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025014725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014726 active site 502025014727 phosphorylation site [posttranslational modification] 502025014728 intermolecular recognition site; other site 502025014729 dimerization interface [polypeptide binding]; other site 502025014730 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 502025014731 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 502025014732 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 502025014733 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 502025014734 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 502025014735 HflX GTPase family; Region: HflX; cd01878 502025014736 G1 box; other site 502025014737 GTP/Mg2+ binding site [chemical binding]; other site 502025014738 Switch I region; other site 502025014739 G2 box; other site 502025014740 G3 box; other site 502025014741 Switch II region; other site 502025014742 G4 box; other site 502025014743 G5 box; other site 502025014744 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 502025014745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025014746 S-adenosylmethionine binding site [chemical binding]; other site 502025014747 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 502025014748 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 502025014749 Zn binding site [ion binding]; other site 502025014750 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014751 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014752 active site 502025014753 ATP binding site [chemical binding]; other site 502025014754 substrate binding site [chemical binding]; other site 502025014755 activation loop (A-loop); other site 502025014756 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025014757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025014758 TPR motif; other site 502025014759 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014760 binding surface 502025014761 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014762 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014763 Domain of unknown function DUF20; Region: UPF0118; pfam01594 502025014764 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 502025014765 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 502025014766 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 502025014767 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 502025014768 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025014769 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025014770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025014772 dimer interface [polypeptide binding]; other site 502025014773 phosphorylation site [posttranslational modification] 502025014774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014775 ATP binding site [chemical binding]; other site 502025014776 Mg2+ binding site [ion binding]; other site 502025014777 G-X-G motif; other site 502025014778 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 502025014779 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 502025014780 Response regulator receiver domain; Region: Response_reg; pfam00072 502025014781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025014782 active site 502025014783 phosphorylation site [posttranslational modification] 502025014784 intermolecular recognition site; other site 502025014785 dimerization interface [polypeptide binding]; other site 502025014786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025014787 PAS domain; Region: PAS_9; pfam13426 502025014788 putative active site [active] 502025014789 heme pocket [chemical binding]; other site 502025014790 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025014791 PAS domain; Region: PAS; smart00091 502025014792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025014793 dimer interface [polypeptide binding]; other site 502025014794 phosphorylation site [posttranslational modification] 502025014795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014796 ATP binding site [chemical binding]; other site 502025014797 Mg2+ binding site [ion binding]; other site 502025014798 G-X-G motif; other site 502025014799 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 502025014800 dimer interface [polypeptide binding]; other site 502025014801 [2Fe-2S] cluster binding site [ion binding]; other site 502025014802 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 502025014803 classical (c) SDRs; Region: SDR_c; cd05233 502025014804 NAD(P) binding site [chemical binding]; other site 502025014805 active site 502025014806 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025014807 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 502025014808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025014809 catalytic residue [active] 502025014810 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 502025014811 oligomerisation interface [polypeptide binding]; other site 502025014812 mobile loop; other site 502025014813 roof hairpin; other site 502025014814 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 502025014815 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 502025014816 ring oligomerisation interface [polypeptide binding]; other site 502025014817 ATP/Mg binding site [chemical binding]; other site 502025014818 stacking interactions; other site 502025014819 hinge regions; other site 502025014820 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 502025014821 Beta-lactamase; Region: Beta-lactamase; pfam00144 502025014822 Surface antigen; Region: Bac_surface_Ag; pfam01103 502025014823 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 502025014824 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 502025014825 Ion channel; Region: Ion_trans_2; pfam07885 502025014826 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 502025014827 intracellular protease, PfpI family; Region: PfpI; TIGR01382 502025014828 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 502025014829 proposed catalytic triad [active] 502025014830 conserved cys residue [active] 502025014831 heat shock protein 90; Provisional; Region: PRK05218 502025014832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025014833 ATP binding site [chemical binding]; other site 502025014834 Mg2+ binding site [ion binding]; other site 502025014835 G-X-G motif; other site 502025014836 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 502025014837 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 502025014838 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 502025014839 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 502025014840 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 502025014841 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 502025014842 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 502025014843 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 502025014844 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 502025014845 Walker A/P-loop; other site 502025014846 ATP binding site [chemical binding]; other site 502025014847 Q-loop/lid; other site 502025014848 ABC transporter signature motif; other site 502025014849 Walker B; other site 502025014850 D-loop; other site 502025014851 H-loop/switch region; other site 502025014852 short chain dehydrogenase; Provisional; Region: PRK07023 502025014853 classical (c) SDRs; Region: SDR_c; cd05233 502025014854 NAD(P) binding site [chemical binding]; other site 502025014855 active site 502025014856 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 502025014857 catalytic residues [active] 502025014858 dimer interface [polypeptide binding]; other site 502025014859 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014860 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014861 active site 502025014862 ATP binding site [chemical binding]; other site 502025014863 substrate binding site [chemical binding]; other site 502025014864 activation loop (A-loop); other site 502025014865 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014867 binding surface 502025014868 TPR motif; other site 502025014869 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025014871 TPR motif; other site 502025014872 binding surface 502025014873 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014874 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014875 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014876 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025014877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 502025014878 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 502025014879 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 502025014880 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 502025014881 Moco binding site; other site 502025014882 metal coordination site [ion binding]; other site 502025014883 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 502025014884 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 502025014885 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 502025014886 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 502025014887 putative active site [active] 502025014888 catalytic site [active] 502025014889 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 502025014890 putative active site [active] 502025014891 catalytic site [active] 502025014892 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 502025014893 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 502025014894 dimerization interface [polypeptide binding]; other site 502025014895 ligand binding site [chemical binding]; other site 502025014896 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 502025014897 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 502025014898 Walker A/P-loop; other site 502025014899 ATP binding site [chemical binding]; other site 502025014900 Q-loop/lid; other site 502025014901 ABC transporter signature motif; other site 502025014902 Walker B; other site 502025014903 D-loop; other site 502025014904 H-loop/switch region; other site 502025014905 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 502025014906 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 502025014907 Walker A/P-loop; other site 502025014908 ATP binding site [chemical binding]; other site 502025014909 Q-loop/lid; other site 502025014910 ABC transporter signature motif; other site 502025014911 Walker B; other site 502025014912 D-loop; other site 502025014913 H-loop/switch region; other site 502025014914 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 502025014915 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 502025014916 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 502025014917 TM-ABC transporter signature motif; other site 502025014918 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 502025014919 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 502025014920 TM-ABC transporter signature motif; other site 502025014921 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 502025014922 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025014923 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 502025014924 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 502025014925 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 502025014926 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 502025014927 dimer interface [polypeptide binding]; other site 502025014928 catalytic triad [active] 502025014929 alpha-glucosidase; Provisional; Region: PRK10137 502025014930 Uncharacterized conserved protein [Function unknown]; Region: COG1432 502025014931 LabA_like proteins; Region: LabA_like; cd06167 502025014932 putative metal binding site [ion binding]; other site 502025014933 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025014934 active site 502025014935 metal binding site [ion binding]; metal-binding site 502025014936 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025014937 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025014938 phosphopeptide binding site; other site 502025014939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025014940 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025014941 Walker A motif; other site 502025014942 ATP binding site [chemical binding]; other site 502025014943 Walker B motif; other site 502025014944 arginine finger; other site 502025014945 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 502025014946 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 502025014947 Peptidase family M1; Region: Peptidase_M1; pfam01433 502025014948 Zn binding site [ion binding]; other site 502025014949 HEAT repeats; Region: HEAT_2; pfam13646 502025014950 HEAT repeats; Region: HEAT_2; pfam13646 502025014951 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 502025014952 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 502025014953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025014954 active site 502025014955 motif I; other site 502025014956 motif II; other site 502025014957 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 502025014958 thymidylate synthase; Reviewed; Region: thyA; PRK01827 502025014959 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 502025014960 dimerization interface [polypeptide binding]; other site 502025014961 active site 502025014962 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 502025014963 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 502025014964 folate binding site [chemical binding]; other site 502025014965 NADP+ binding site [chemical binding]; other site 502025014966 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 502025014967 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 502025014968 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 502025014969 NAD(P) binding pocket [chemical binding]; other site 502025014970 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 502025014971 aromatic arch; other site 502025014972 DCoH dimer interaction site [polypeptide binding]; other site 502025014973 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 502025014974 DCoH tetramer interaction site [polypeptide binding]; other site 502025014975 substrate binding site [chemical binding]; other site 502025014976 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025014977 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025014978 active site 502025014979 ATP binding site [chemical binding]; other site 502025014980 substrate binding site [chemical binding]; other site 502025014981 activation loop (A-loop); other site 502025014982 Protein phosphatase 2C; Region: PP2C; pfam00481 502025014983 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025014984 active site 502025014985 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025014986 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025014987 ligand binding site [chemical binding]; other site 502025014988 flexible hinge region; other site 502025014989 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025014990 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025014991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014992 NAD(P) binding site [chemical binding]; other site 502025014993 active site 502025014994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025014995 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 502025014996 NAD(P) binding site [chemical binding]; other site 502025014997 active site 502025014998 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 502025014999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 502025015000 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 502025015001 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025015002 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025015003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025015004 binding surface 502025015005 TPR motif; other site 502025015006 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 502025015007 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 502025015008 active site 502025015009 Double zinc ribbon; Region: DZR; pfam12773 502025015010 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 502025015011 CAAX protease self-immunity; Region: Abi; pfam02517 502025015012 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 502025015013 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 502025015014 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 502025015015 catalytic core [active] 502025015016 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 502025015017 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 502025015018 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025015019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015020 binding surface 502025015021 TPR motif; other site 502025015022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015023 TPR motif; other site 502025015024 binding surface 502025015025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015026 TPR motif; other site 502025015027 binding surface 502025015028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015029 TPR motif; other site 502025015030 binding surface 502025015031 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025015032 anti sigma factor interaction site; other site 502025015033 regulatory phosphorylation site [posttranslational modification]; other site 502025015034 PAS domain; Region: PAS_9; pfam13426 502025015035 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025015036 anti sigma factor interaction site; other site 502025015037 regulatory phosphorylation site [posttranslational modification]; other site 502025015038 PAS fold; Region: PAS_4; pfam08448 502025015039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015040 dimer interface [polypeptide binding]; other site 502025015041 phosphorylation site [posttranslational modification] 502025015042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015043 ATP binding site [chemical binding]; other site 502025015044 Mg2+ binding site [ion binding]; other site 502025015045 G-X-G motif; other site 502025015046 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025015047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015048 active site 502025015049 phosphorylation site [posttranslational modification] 502025015050 intermolecular recognition site; other site 502025015051 dimerization interface [polypeptide binding]; other site 502025015052 Lipase (class 2); Region: Lipase_2; pfam01674 502025015053 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 502025015054 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 502025015055 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025015056 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 502025015057 acyl-activating enzyme (AAE) consensus motif; other site 502025015058 putative AMP binding site [chemical binding]; other site 502025015059 putative active site [active] 502025015060 putative CoA binding site [chemical binding]; other site 502025015061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025015062 AAA domain; Region: AAA_21; pfam13304 502025015063 Walker A/P-loop; other site 502025015064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025015065 Walker B; other site 502025015066 D-loop; other site 502025015067 H-loop/switch region; other site 502025015068 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535 502025015069 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 502025015070 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025015071 carboxyltransferase (CT) interaction site; other site 502025015072 biotinylation site [posttranslational modification]; other site 502025015073 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 502025015074 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 502025015075 Arginase family; Region: Arginase; cd09989 502025015076 active site 502025015077 Mn binding site [ion binding]; other site 502025015078 oligomer interface [polypeptide binding]; other site 502025015079 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 502025015080 putative di-iron ligands [ion binding]; other site 502025015081 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 502025015082 AAA domain; Region: AAA_22; pfam13401 502025015083 AAA ATPase domain; Region: AAA_16; pfam13191 502025015084 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 502025015085 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025015086 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 502025015087 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 502025015088 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 502025015089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025015090 dimer interface [polypeptide binding]; other site 502025015091 conserved gate region; other site 502025015092 putative PBP binding loops; other site 502025015093 ABC-ATPase subunit interface; other site 502025015094 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 502025015095 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 502025015096 Walker A/P-loop; other site 502025015097 ATP binding site [chemical binding]; other site 502025015098 Q-loop/lid; other site 502025015099 ABC transporter signature motif; other site 502025015100 Walker B; other site 502025015101 D-loop; other site 502025015102 H-loop/switch region; other site 502025015103 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025015104 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 502025015105 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 502025015106 DNA binding residues [nucleotide binding] 502025015107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 502025015108 Walker A motif; other site 502025015109 ATP binding site [chemical binding]; other site 502025015110 Walker B motif; other site 502025015111 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 502025015112 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 502025015113 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 502025015114 hinge; other site 502025015115 active site 502025015116 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 502025015117 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 502025015118 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025015119 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025015120 ligand binding site [chemical binding]; other site 502025015121 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025015122 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025015123 phosphopeptide binding site; other site 502025015124 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025015125 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025015126 phosphopeptide binding site; other site 502025015127 TPR repeat; Region: TPR_11; pfam13414 502025015128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015129 TPR motif; other site 502025015130 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 502025015131 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 502025015132 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 502025015133 Walker A/P-loop; other site 502025015134 ATP binding site [chemical binding]; other site 502025015135 Q-loop/lid; other site 502025015136 ABC transporter signature motif; other site 502025015137 Walker B; other site 502025015138 D-loop; other site 502025015139 H-loop/switch region; other site 502025015140 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025015141 metal binding site [ion binding]; metal-binding site 502025015142 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 502025015143 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 502025015144 Peptidase S46; Region: Peptidase_S46; pfam10459 502025015145 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025015146 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025015147 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025015148 active site 502025015149 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 502025015150 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 502025015151 active site 502025015152 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025015153 Cytochrome P450; Region: p450; cl12078 502025015154 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 502025015155 active site 502025015156 catalytic residues [active] 502025015157 enoyl-CoA hydratase; Provisional; Region: PRK06563 502025015158 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025015159 substrate binding site [chemical binding]; other site 502025015160 oxyanion hole (OAH) forming residues; other site 502025015161 trimer interface [polypeptide binding]; other site 502025015162 Predicted methyltransferase [General function prediction only]; Region: COG4798 502025015163 S-adenosylmethionine binding site [chemical binding]; other site 502025015164 PhoD-like phosphatase; Region: PhoD; pfam09423 502025015165 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 502025015166 putative active site [active] 502025015167 putative metal binding site [ion binding]; other site 502025015168 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025015169 Cupin domain; Region: Cupin_2; cl17218 502025015170 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 502025015171 active site 502025015172 Zn binding site [ion binding]; other site 502025015173 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 502025015174 active site 502025015175 catalytic triad [active] 502025015176 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 502025015177 ribonuclease G; Provisional; Region: PRK11712 502025015178 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 502025015179 homodimer interface [polypeptide binding]; other site 502025015180 oligonucleotide binding site [chemical binding]; other site 502025015181 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015182 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015183 active site 502025015184 ATP binding site [chemical binding]; other site 502025015185 substrate binding site [chemical binding]; other site 502025015186 activation loop (A-loop); other site 502025015187 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 502025015188 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 502025015189 active site 502025015190 8-oxo-dGMP binding site [chemical binding]; other site 502025015191 nudix motif; other site 502025015192 metal binding site [ion binding]; metal-binding site 502025015193 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 502025015194 active site residue [active] 502025015195 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 502025015196 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025015197 acyl-activating enzyme (AAE) consensus motif; other site 502025015198 AMP binding site [chemical binding]; other site 502025015199 active site 502025015200 CoA binding site [chemical binding]; other site 502025015201 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 502025015202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025015203 dimer interface [polypeptide binding]; other site 502025015204 conserved gate region; other site 502025015205 putative PBP binding loops; other site 502025015206 ABC-ATPase subunit interface; other site 502025015207 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 502025015208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025015209 dimer interface [polypeptide binding]; other site 502025015210 conserved gate region; other site 502025015211 putative PBP binding loops; other site 502025015212 ABC-ATPase subunit interface; other site 502025015213 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 502025015214 iron-sulfur cluster [ion binding]; other site 502025015215 [2Fe-2S] cluster binding site [ion binding]; other site 502025015216 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025015217 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025015218 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025015219 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025015220 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 502025015221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025015222 argininosuccinate lyase; Provisional; Region: PRK00855 502025015223 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 502025015224 active sites [active] 502025015225 tetramer interface [polypeptide binding]; other site 502025015226 diaminopimelate decarboxylase; Region: lysA; TIGR01048 502025015227 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 502025015228 active site 502025015229 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025015230 substrate binding site [chemical binding]; other site 502025015231 catalytic residues [active] 502025015232 dimer interface [polypeptide binding]; other site 502025015233 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015234 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015235 active site 502025015236 ATP binding site [chemical binding]; other site 502025015237 substrate binding site [chemical binding]; other site 502025015238 activation loop (A-loop); other site 502025015239 AAA domain; Region: AAA_22; pfam13401 502025015240 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015241 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015242 active site 502025015243 ATP binding site [chemical binding]; other site 502025015244 substrate binding site [chemical binding]; other site 502025015245 activation loop (A-loop); other site 502025015246 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015247 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015248 active site 502025015249 ATP binding site [chemical binding]; other site 502025015250 substrate binding site [chemical binding]; other site 502025015251 activation loop (A-loop); other site 502025015252 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025015253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015254 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025015255 substrate binding site [chemical binding]; other site 502025015256 activation loop (A-loop); other site 502025015257 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 502025015258 AAA ATPase domain; Region: AAA_16; pfam13191 502025015259 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 502025015260 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 502025015261 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 502025015262 active site 502025015263 dimer interface [polypeptide binding]; other site 502025015264 effector binding site; other site 502025015265 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 502025015266 TSCPD domain; Region: TSCPD; pfam12637 502025015267 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015269 active site 502025015270 phosphorylation site [posttranslational modification] 502025015271 intermolecular recognition site; other site 502025015272 dimerization interface [polypeptide binding]; other site 502025015273 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015275 dimer interface [polypeptide binding]; other site 502025015276 phosphorylation site [posttranslational modification] 502025015277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015278 ATP binding site [chemical binding]; other site 502025015279 Mg2+ binding site [ion binding]; other site 502025015280 G-X-G motif; other site 502025015281 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015283 ATP binding site [chemical binding]; other site 502025015284 Mg2+ binding site [ion binding]; other site 502025015285 G-X-G motif; other site 502025015286 photoactive yellow protein; Region: photo_yellow; TIGR02373 502025015287 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 502025015288 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025015289 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025015290 active site 502025015291 metal binding site [ion binding]; metal-binding site 502025015292 FHA domain; Region: FHA; pfam00498 502025015293 phosphopeptide binding site; other site 502025015294 aspartate aminotransferase; Provisional; Region: PRK06836 502025015295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 502025015296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025015297 homodimer interface [polypeptide binding]; other site 502025015298 catalytic residue [active] 502025015299 Cytochrome P450; Region: p450; cl12078 502025015300 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025015301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025015302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025015303 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 502025015304 Flavoprotein; Region: Flavoprotein; pfam02441 502025015305 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 502025015306 Flavoprotein; Region: Flavoprotein; pfam02441 502025015307 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 502025015308 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025015309 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 502025015310 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025015311 acetyl-CoA synthetase; Provisional; Region: PRK00174 502025015312 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 502025015313 active site 502025015314 CoA binding site [chemical binding]; other site 502025015315 acyl-activating enzyme (AAE) consensus motif; other site 502025015316 AMP binding site [chemical binding]; other site 502025015317 acetate binding site [chemical binding]; other site 502025015318 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 502025015319 homotrimer interaction site [polypeptide binding]; other site 502025015320 putative active site [active] 502025015321 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 502025015322 ADP-ribose binding site [chemical binding]; other site 502025015323 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 502025015324 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 502025015325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015326 active site 502025015327 phosphorylation site [posttranslational modification] 502025015328 intermolecular recognition site; other site 502025015329 dimerization interface [polypeptide binding]; other site 502025015330 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025015331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015333 ATP binding site [chemical binding]; other site 502025015334 Mg2+ binding site [ion binding]; other site 502025015335 G-X-G motif; other site 502025015336 Ion channel; Region: Ion_trans_2; pfam07885 502025015337 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 502025015338 TrkA-N domain; Region: TrkA_N; pfam02254 502025015339 TrkA-C domain; Region: TrkA_C; pfam02080 502025015340 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 502025015341 DnaJ domain; Region: DnaJ; pfam00226 502025015342 primosomal protein N' Region: priA; TIGR00595 502025015343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025015344 ATP binding site [chemical binding]; other site 502025015345 putative Mg++ binding site [ion binding]; other site 502025015346 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 502025015347 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 502025015348 active site 502025015349 tetramer interface; other site 502025015350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025015351 DNA binding residues [nucleotide binding] 502025015352 dimerization interface [polypeptide binding]; other site 502025015353 peptide chain release factor 2; Validated; Region: prfB; PRK00578 502025015354 This domain is found in peptide chain release factors; Region: PCRF; smart00937 502025015355 RF-1 domain; Region: RF-1; pfam00472 502025015356 amidophosphoribosyltransferase; Provisional; Region: PRK09123 502025015357 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 502025015358 active site 502025015359 tetramer interface [polypeptide binding]; other site 502025015360 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 502025015361 active site 502025015362 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025015363 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025015364 phosphopeptide binding site; other site 502025015365 SPX domain; Region: SPX; pfam03105 502025015366 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 502025015367 DNA binding site [nucleotide binding] 502025015368 active site 502025015369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015370 dimer interface [polypeptide binding]; other site 502025015371 phosphorylation site [posttranslational modification] 502025015372 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 502025015373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015374 ATP binding site [chemical binding]; other site 502025015375 Mg2+ binding site [ion binding]; other site 502025015376 G-X-G motif; other site 502025015377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025015379 dimerization interface [polypeptide binding]; other site 502025015380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015381 dimer interface [polypeptide binding]; other site 502025015382 phosphorylation site [posttranslational modification] 502025015383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015384 ATP binding site [chemical binding]; other site 502025015385 Mg2+ binding site [ion binding]; other site 502025015386 G-X-G motif; other site 502025015387 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015389 active site 502025015390 phosphorylation site [posttranslational modification] 502025015391 intermolecular recognition site; other site 502025015392 dimerization interface [polypeptide binding]; other site 502025015393 Sulfatase; Region: Sulfatase; cl17466 502025015394 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 502025015395 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 502025015396 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 502025015397 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 502025015398 active site 502025015399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025015400 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 502025015401 fumarate hydratase; Provisional; Region: PRK15389 502025015402 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 502025015403 Fumarase C-terminus; Region: Fumerase_C; pfam05683 502025015404 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 502025015405 metal ion-dependent adhesion site (MIDAS); other site 502025015406 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 502025015407 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025015408 putative active site [active] 502025015409 heme pocket [chemical binding]; other site 502025015410 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025015411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025015412 putative active site [active] 502025015413 heme pocket [chemical binding]; other site 502025015414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015415 dimer interface [polypeptide binding]; other site 502025015416 phosphorylation site [posttranslational modification] 502025015417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015418 ATP binding site [chemical binding]; other site 502025015419 Mg2+ binding site [ion binding]; other site 502025015420 G-X-G motif; other site 502025015421 6-phosphogluconolactonase; Provisional; Region: PRK11028 502025015422 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025015423 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 502025015424 MAPEG family; Region: MAPEG; pfam01124 502025015425 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025015426 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025015427 CHAT domain; Region: CHAT; cl17868 502025015428 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 502025015429 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025015430 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025015431 DNA binding residues [nucleotide binding] 502025015432 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015433 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015434 active site 502025015435 ATP binding site [chemical binding]; other site 502025015436 substrate binding site [chemical binding]; other site 502025015437 activation loop (A-loop); other site 502025015438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025015439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015440 TPR motif; other site 502025015441 binding surface 502025015442 Caspase domain; Region: Peptidase_C14; pfam00656 502025015443 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 502025015444 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 502025015445 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 502025015446 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 502025015447 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 502025015448 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 502025015449 TIR domain; Region: TIR_2; pfam13676 502025015450 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025015451 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 502025015452 G1 box; other site 502025015453 GTP/Mg2+ binding site [chemical binding]; other site 502025015454 Switch I region; other site 502025015455 G2 box; other site 502025015456 G3 box; other site 502025015457 Switch II region; other site 502025015458 G4 box; other site 502025015459 G5 box; other site 502025015460 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 502025015461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025015462 Coenzyme A binding pocket [chemical binding]; other site 502025015463 PEGA domain; Region: PEGA; pfam08308 502025015464 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015465 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015466 active site 502025015467 ATP binding site [chemical binding]; other site 502025015468 substrate binding site [chemical binding]; other site 502025015469 activation loop (A-loop); other site 502025015470 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 502025015471 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 502025015472 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 502025015473 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025015474 Protein kinase domain; Region: Pkinase; pfam00069 502025015475 active site 502025015476 ATP binding site [chemical binding]; other site 502025015477 substrate binding site [chemical binding]; other site 502025015478 activation loop (A-loop); other site 502025015479 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025015480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015481 TPR motif; other site 502025015482 binding surface 502025015483 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025015484 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025015485 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 502025015486 YndJ-like protein; Region: YndJ; pfam14158 502025015487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 502025015488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025015489 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015490 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015491 active site 502025015492 ATP binding site [chemical binding]; other site 502025015493 substrate binding site [chemical binding]; other site 502025015494 activation loop (A-loop); other site 502025015495 AAA ATPase domain; Region: AAA_16; pfam13191 502025015496 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025015497 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025015498 structural tetrad; other site 502025015499 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 502025015500 structural tetrad; other site 502025015501 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015502 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015503 active site 502025015504 ATP binding site [chemical binding]; other site 502025015505 substrate binding site [chemical binding]; other site 502025015506 activation loop (A-loop); other site 502025015507 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 502025015508 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 502025015509 Cupin domain; Region: Cupin_2; cl17218 502025015510 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 502025015511 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 502025015512 TMP-binding site; other site 502025015513 ATP-binding site [chemical binding]; other site 502025015514 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025015515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025015516 active site 502025015517 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 502025015518 Transglutaminase/protease-like homologues; Region: TGc; smart00460 502025015519 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025015520 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025015521 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025015522 catalytic residues [active] 502025015523 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 502025015524 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 502025015525 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 502025015526 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 502025015527 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 502025015528 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025015529 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025015530 Surface antigen; Region: Bac_surface_Ag; pfam01103 502025015531 TPR repeat; Region: TPR_11; pfam13414 502025015532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015533 binding surface 502025015534 TPR motif; other site 502025015535 TPR repeat; Region: TPR_11; pfam13414 502025015536 TPR repeat; Region: TPR_11; pfam13414 502025015537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015538 binding surface 502025015539 TPR motif; other site 502025015540 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025015541 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025015542 phosphopeptide binding site; other site 502025015543 pseudo-rSAM protein, GG-Bacteroidales system; Region: pseudo_rSAM_GG; TIGR04150 502025015544 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 502025015545 Fatty acid desaturase; Region: FA_desaturase; pfam00487 502025015546 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 502025015547 putative di-iron ligands [ion binding]; other site 502025015548 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025015549 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015550 active site 502025015551 ATP binding site [chemical binding]; other site 502025015552 substrate binding site [chemical binding]; other site 502025015553 activation loop (A-loop); other site 502025015554 AAA ATPase domain; Region: AAA_16; pfam13191 502025015555 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025015556 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025015557 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025015558 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025015559 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025015560 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025015561 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 502025015562 catalytic loop [active] 502025015563 iron binding site [ion binding]; other site 502025015564 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025015565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015566 dimer interface [polypeptide binding]; other site 502025015567 phosphorylation site [posttranslational modification] 502025015568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015569 ATP binding site [chemical binding]; other site 502025015570 Mg2+ binding site [ion binding]; other site 502025015571 G-X-G motif; other site 502025015572 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 502025015573 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025015574 RNA binding surface [nucleotide binding]; other site 502025015575 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 502025015576 active site 502025015577 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 502025015578 ScpA/B protein; Region: ScpA_ScpB; cl00598 502025015579 Peptidase family M50; Region: Peptidase_M50; pfam02163 502025015580 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 502025015581 active site 502025015582 putative substrate binding region [chemical binding]; other site 502025015583 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 502025015584 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 502025015585 active site 502025015586 DNA binding site [nucleotide binding] 502025015587 Int/Topo IB signature motif; other site 502025015588 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025015589 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025015590 ligand binding site [chemical binding]; other site 502025015591 flexible hinge region; other site 502025015592 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 502025015593 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 502025015594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025015595 Walker A/P-loop; other site 502025015596 ATP binding site [chemical binding]; other site 502025015597 Q-loop/lid; other site 502025015598 ABC transporter signature motif; other site 502025015599 Walker B; other site 502025015600 D-loop; other site 502025015601 H-loop/switch region; other site 502025015602 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 502025015603 ATP cone domain; Region: ATP-cone; pfam03477 502025015604 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 502025015605 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 502025015606 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 502025015607 dimer interface [polypeptide binding]; other site 502025015608 active site 502025015609 acyl carrier protein; Provisional; Region: acpP; PRK00982 502025015610 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025015611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025015612 NAD(P) binding site [chemical binding]; other site 502025015613 active site 502025015614 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 502025015615 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 502025015616 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 502025015617 putative catalytic site [active] 502025015618 putative phosphate binding site [ion binding]; other site 502025015619 active site 502025015620 metal binding site A [ion binding]; metal-binding site 502025015621 DNA binding site [nucleotide binding] 502025015622 putative AP binding site [nucleotide binding]; other site 502025015623 putative metal binding site B [ion binding]; other site 502025015624 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 502025015625 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 502025015626 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 502025015627 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 502025015628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025015629 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 502025015630 Walker A/P-loop; other site 502025015631 ATP binding site [chemical binding]; other site 502025015632 Q-loop/lid; other site 502025015633 ABC transporter signature motif; other site 502025015634 Walker B; other site 502025015635 D-loop; other site 502025015636 H-loop/switch region; other site 502025015637 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025015638 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025015639 GAF domain; Region: GAF; pfam01590 502025015640 GAF domain; Region: GAF_2; pfam13185 502025015641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015643 dimer interface [polypeptide binding]; other site 502025015644 phosphorylation site [posttranslational modification] 502025015645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015646 ATP binding site [chemical binding]; other site 502025015647 Mg2+ binding site [ion binding]; other site 502025015648 G-X-G motif; other site 502025015649 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 502025015650 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 502025015651 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025015652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025015653 CHAT domain; Region: CHAT; cl17868 502025015654 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 502025015655 active site 502025015656 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025015657 AAA domain; Region: AAA_14; pfam13173 502025015658 SIR2-like domain; Region: SIR2_2; pfam13289 502025015659 Transglycosylase; Region: Transgly; pfam00912 502025015660 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 502025015661 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 502025015662 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 502025015663 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 502025015664 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025015665 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025015666 phosphopeptide binding site; other site 502025015667 Peptidase family M1; Region: Peptidase_M1; pfam01433 502025015668 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 502025015669 Zn binding site [ion binding]; other site 502025015670 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 502025015671 LysE type translocator; Region: LysE; cl00565 502025015672 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025015673 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025015674 putative active site [active] 502025015675 putative metal binding site [ion binding]; other site 502025015676 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025015677 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 502025015678 putative ligand binding pocket/active site [active] 502025015679 putative metal binding site [ion binding]; other site 502025015680 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 502025015681 ferrochelatase; Reviewed; Region: hemH; PRK00035 502025015682 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 502025015683 C-terminal domain interface [polypeptide binding]; other site 502025015684 active site 502025015685 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 502025015686 active site 502025015687 N-terminal domain interface [polypeptide binding]; other site 502025015688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 502025015689 active site 502025015690 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 502025015691 glycosyltransferase, MGT family; Region: MGT; TIGR01426 502025015692 active site 502025015693 TDP-binding site; other site 502025015694 acceptor substrate-binding pocket; other site 502025015695 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 502025015696 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 502025015697 active site 502025015698 dimer interface [polypeptide binding]; other site 502025015699 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 502025015700 Ligand Binding Site [chemical binding]; other site 502025015701 Molecular Tunnel; other site 502025015702 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 502025015703 Ligand Binding Site [chemical binding]; other site 502025015704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025015705 FeS/SAM binding site; other site 502025015706 RibD C-terminal domain; Region: RibD_C; cl17279 502025015707 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 502025015708 Protein of unknown function, DUF393; Region: DUF393; pfam04134 502025015709 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 502025015710 active site 502025015711 catalytic site [active] 502025015712 substrate binding site [chemical binding]; other site 502025015713 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 502025015714 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025015715 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 502025015716 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 502025015717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 502025015718 ATP binding site [chemical binding]; other site 502025015719 putative Mg++ binding site [ion binding]; other site 502025015720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025015721 nucleotide binding region [chemical binding]; other site 502025015722 ATP-binding site [chemical binding]; other site 502025015723 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 502025015724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 502025015725 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 502025015726 PA14 domain; Region: PA14; pfam07691 502025015727 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025015728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025015729 non-specific DNA binding site [nucleotide binding]; other site 502025015730 salt bridge; other site 502025015731 sequence-specific DNA binding site [nucleotide binding]; other site 502025015732 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 502025015733 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 502025015734 metal binding triad; other site 502025015735 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 502025015736 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 502025015737 metal binding triad; other site 502025015738 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 502025015739 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 502025015740 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025015741 HSP70 interaction site [polypeptide binding]; other site 502025015742 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 502025015743 Zn binding sites [ion binding]; other site 502025015744 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 502025015745 dimer interface [polypeptide binding]; other site 502025015746 Domain of unknown function (DUF202); Region: DUF202; pfam02656 502025015747 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 502025015748 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 502025015749 TrkA-N domain; Region: TrkA_N; pfam02254 502025015750 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 502025015751 TrkA-C domain; Region: TrkA_C; pfam02080 502025015752 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 502025015753 MutS domain III; Region: MutS_III; pfam05192 502025015754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025015755 Walker A/P-loop; other site 502025015756 ATP binding site [chemical binding]; other site 502025015757 Q-loop/lid; other site 502025015758 ABC transporter signature motif; other site 502025015759 Walker B; other site 502025015760 D-loop; other site 502025015761 H-loop/switch region; other site 502025015762 Smr domain; Region: Smr; pfam01713 502025015763 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025015764 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025015765 phosphopeptide binding site; other site 502025015766 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025015767 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025015768 metal binding site [ion binding]; metal-binding site 502025015769 active site 502025015770 I-site; other site 502025015771 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 502025015772 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 502025015773 substrate binding pocket [chemical binding]; other site 502025015774 chain length determination region; other site 502025015775 substrate-Mg2+ binding site; other site 502025015776 catalytic residues [active] 502025015777 aspartate-rich region 1; other site 502025015778 active site lid residues [active] 502025015779 aspartate-rich region 2; other site 502025015780 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 502025015781 helix swapped region; other site 502025015782 homodimer interface [polypeptide binding]; other site 502025015783 substrate binding pocket [chemical binding]; other site 502025015784 catalytic residues [active] 502025015785 NADH/NADPH cofactor binding site [chemical binding]; other site 502025015786 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 502025015787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025015788 S-adenosylmethionine binding site [chemical binding]; other site 502025015789 chorismate binding enzyme; Region: Chorismate_bind; cl10555 502025015790 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 502025015791 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 502025015792 dimer interface [polypeptide binding]; other site 502025015793 tetramer interface [polypeptide binding]; other site 502025015794 PYR/PP interface [polypeptide binding]; other site 502025015795 TPP binding site [chemical binding]; other site 502025015796 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 502025015797 TPP-binding site [chemical binding]; other site 502025015798 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 502025015799 UbiA prenyltransferase family; Region: UbiA; pfam01040 502025015800 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 502025015801 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 502025015802 metal binding site [ion binding]; metal-binding site 502025015803 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 502025015804 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025015805 acyl-activating enzyme (AAE) consensus motif; other site 502025015806 AMP binding site [chemical binding]; other site 502025015807 active site 502025015808 CoA binding site [chemical binding]; other site 502025015809 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025015810 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025015811 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025015812 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025015813 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025015814 EamA-like transporter family; Region: EamA; pfam00892 502025015815 EamA-like transporter family; Region: EamA; pfam00892 502025015816 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 502025015817 Yqey-like protein; Region: YqeY; cl17540 502025015818 impB/mucB/samB family; Region: IMS; pfam00817 502025015819 active site 502025015820 glutathione reductase; Validated; Region: PRK06116 502025015821 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025015822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025015823 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025015824 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025015825 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025015826 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 502025015827 Beta-lactamase; Region: Beta-lactamase; pfam00144 502025015828 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 502025015829 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 502025015830 CoenzymeA binding site [chemical binding]; other site 502025015831 subunit interaction site [polypeptide binding]; other site 502025015832 PHB binding site; other site 502025015833 Peptidase S46; Region: Peptidase_S46; pfam10459 502025015834 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025015835 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025015836 putative catalytic site [active] 502025015837 putative metal binding site [ion binding]; other site 502025015838 putative phosphate binding site [ion binding]; other site 502025015839 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 502025015840 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 502025015841 amidase catalytic site [active] 502025015842 Zn binding residues [ion binding]; other site 502025015843 substrate binding site [chemical binding]; other site 502025015844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025015845 S-adenosylmethionine binding site [chemical binding]; other site 502025015846 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 502025015847 putative active site [active] 502025015848 putative metal binding site [ion binding]; other site 502025015849 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 502025015850 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025015851 NAD(P) binding site [chemical binding]; other site 502025015852 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 502025015853 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 502025015854 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 502025015855 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 502025015856 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 502025015857 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 502025015858 Na binding site [ion binding]; other site 502025015859 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025015860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025015861 putative active site [active] 502025015862 heme pocket [chemical binding]; other site 502025015863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015864 dimer interface [polypeptide binding]; other site 502025015865 phosphorylation site [posttranslational modification] 502025015866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015867 ATP binding site [chemical binding]; other site 502025015868 Mg2+ binding site [ion binding]; other site 502025015869 G-X-G motif; other site 502025015870 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015872 active site 502025015873 phosphorylation site [posttranslational modification] 502025015874 intermolecular recognition site; other site 502025015875 dimerization interface [polypeptide binding]; other site 502025015876 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 502025015877 nudix motif; other site 502025015878 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 502025015879 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 502025015880 active site 502025015881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025015882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025015883 metal binding site [ion binding]; metal-binding site 502025015884 active site 502025015885 I-site; other site 502025015886 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 502025015887 AAA domain; Region: AAA_30; pfam13604 502025015888 Family description; Region: UvrD_C_2; pfam13538 502025015889 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 502025015890 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 502025015891 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 502025015892 putative active site [active] 502025015893 putative metal binding site [ion binding]; other site 502025015894 NACHT domain; Region: NACHT; pfam05729 502025015895 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 502025015896 Family description; Region: VCBS; pfam13517 502025015897 Family description; Region: VCBS; pfam13517 502025015898 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 502025015899 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025015900 RHS Repeat; Region: RHS_repeat; pfam05593 502025015901 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025015902 Predicted transcriptional regulator [Transcription]; Region: COG2378 502025015903 WYL domain; Region: WYL; pfam13280 502025015904 Predicted transcriptional regulator [Transcription]; Region: COG2378 502025015905 WYL domain; Region: WYL; pfam13280 502025015906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025015907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 502025015908 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 502025015909 urocanate hydratase; Provisional; Region: PRK05414 502025015910 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 502025015911 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 502025015912 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 502025015913 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 502025015914 dimer interface [polypeptide binding]; other site 502025015915 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 502025015916 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 502025015917 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 502025015918 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 502025015919 active site 502025015920 homotetramer interface [polypeptide binding]; other site 502025015921 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 502025015922 N-formylglutamate amidohydrolase; Region: FGase; cl01522 502025015923 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 502025015924 Beta-lactamase; Region: Beta-lactamase; pfam00144 502025015925 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 502025015926 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025015927 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025015928 active site 502025015929 catalytic tetrad [active] 502025015930 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025015931 GAF domain; Region: GAF; pfam01590 502025015932 GAF domain; Region: GAF_2; pfam13185 502025015933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025015934 dimer interface [polypeptide binding]; other site 502025015935 phosphorylation site [posttranslational modification] 502025015936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015937 ATP binding site [chemical binding]; other site 502025015938 Mg2+ binding site [ion binding]; other site 502025015939 G-X-G motif; other site 502025015940 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 502025015941 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025015942 ligand binding site [chemical binding]; other site 502025015943 Right handed beta helix region; Region: Beta_helix; pfam13229 502025015944 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 502025015945 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 502025015946 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 502025015947 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 502025015948 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 502025015949 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025015950 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 502025015951 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 502025015952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025015953 ATP binding site [chemical binding]; other site 502025015954 Mg2+ binding site [ion binding]; other site 502025015955 G-X-G motif; other site 502025015956 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 502025015957 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 502025015958 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 502025015959 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 502025015960 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025015961 phosphopeptide binding site; other site 502025015962 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 502025015963 DNA binding site [nucleotide binding] 502025015964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015965 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015966 active site 502025015967 ATP binding site [chemical binding]; other site 502025015968 substrate binding site [chemical binding]; other site 502025015969 activation loop (A-loop); other site 502025015970 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015971 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015972 active site 502025015973 ATP binding site [chemical binding]; other site 502025015974 substrate binding site [chemical binding]; other site 502025015975 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025015976 activation loop (A-loop); other site 502025015977 activation loop (A-loop); other site 502025015978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025015979 Walker A/P-loop; other site 502025015980 ATP binding site [chemical binding]; other site 502025015981 ABC transporter signature motif; other site 502025015982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025015983 binding surface 502025015984 TPR motif; other site 502025015985 Response regulator receiver domain; Region: Response_reg; pfam00072 502025015986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025015987 active site 502025015988 phosphorylation site [posttranslational modification] 502025015989 intermolecular recognition site; other site 502025015990 dimerization interface [polypeptide binding]; other site 502025015991 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025015992 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025015993 active site 502025015994 ATP binding site [chemical binding]; other site 502025015995 substrate binding site [chemical binding]; other site 502025015996 activation loop (A-loop); other site 502025015997 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 502025015998 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 502025015999 ligand binding site; other site 502025016000 oligomer interface; other site 502025016001 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 502025016002 dimer interface [polypeptide binding]; other site 502025016003 N-terminal domain interface [polypeptide binding]; other site 502025016004 sulfate 1 binding site; other site 502025016005 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 502025016006 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025016007 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 502025016008 putative C-terminal domain interface [polypeptide binding]; other site 502025016009 putative GSH binding site (G-site) [chemical binding]; other site 502025016010 putative dimer interface [polypeptide binding]; other site 502025016011 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025016012 N-terminal domain interface [polypeptide binding]; other site 502025016013 dimer interface [polypeptide binding]; other site 502025016014 substrate binding pocket (H-site) [chemical binding]; other site 502025016015 Cupin domain; Region: Cupin_2; pfam07883 502025016016 Transcriptional regulators [Transcription]; Region: MarR; COG1846 502025016017 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 502025016018 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025016019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025016020 S-adenosylmethionine binding site [chemical binding]; other site 502025016021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025016022 PAS fold; Region: PAS_3; pfam08447 502025016023 putative active site [active] 502025016024 heme pocket [chemical binding]; other site 502025016025 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 502025016026 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 502025016027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025016028 putative active site [active] 502025016029 heme pocket [chemical binding]; other site 502025016030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025016031 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025016032 putative active site [active] 502025016033 heme pocket [chemical binding]; other site 502025016034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025016035 dimer interface [polypeptide binding]; other site 502025016036 phosphorylation site [posttranslational modification] 502025016037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016038 ATP binding site [chemical binding]; other site 502025016039 Mg2+ binding site [ion binding]; other site 502025016040 G-X-G motif; other site 502025016041 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016043 active site 502025016044 phosphorylation site [posttranslational modification] 502025016045 intermolecular recognition site; other site 502025016046 Phosphotransferase enzyme family; Region: APH; pfam01636 502025016047 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 502025016048 active site 502025016049 ATP binding site [chemical binding]; other site 502025016050 substrate binding site [chemical binding]; other site 502025016051 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 502025016052 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 502025016053 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 502025016054 proline dipeptidase; Provisional; Region: PRK13607 502025016055 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 502025016056 active site 502025016057 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016058 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016059 active site 502025016060 ATP binding site [chemical binding]; other site 502025016061 substrate binding site [chemical binding]; other site 502025016062 activation loop (A-loop); other site 502025016063 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 502025016064 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 502025016065 putative hexamer interface [polypeptide binding]; other site 502025016066 putative hexagonal pore; other site 502025016067 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 502025016068 putative hexamer interface [polypeptide binding]; other site 502025016069 putative hexagonal pore; other site 502025016070 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 502025016071 putative catalytic cysteine [active] 502025016072 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 502025016073 Hexamer/Pentamer interface [polypeptide binding]; other site 502025016074 central pore; other site 502025016075 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 502025016076 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 502025016077 Hexamer interface [polypeptide binding]; other site 502025016078 Hexagonal pore residue; other site 502025016079 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 502025016080 putative hexamer interface [polypeptide binding]; other site 502025016081 putative hexagonal pore; other site 502025016082 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 502025016083 Hexamer interface [polypeptide binding]; other site 502025016084 Hexagonal pore residue; other site 502025016085 Clostripain family; Region: Peptidase_C11; pfam03415 502025016086 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 502025016087 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 502025016088 TPR repeat; Region: TPR_11; pfam13414 502025016089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025016090 binding surface 502025016091 TPR motif; other site 502025016092 TPR repeat; Region: TPR_11; pfam13414 502025016093 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025016094 Tetratricopeptide repeat; Region: TPR_17; pfam13431 502025016095 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 502025016096 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 502025016097 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 502025016098 Helix-hairpin-helix motif; Region: HHH; pfam00633 502025016099 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025016100 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 502025016101 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 502025016102 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 502025016103 active site 502025016104 dimer interface [polypeptide binding]; other site 502025016105 metal binding site [ion binding]; metal-binding site 502025016106 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 502025016107 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 502025016108 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 502025016109 putative active site [active] 502025016110 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 502025016111 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 502025016112 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 502025016113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016114 NAD(P) binding site [chemical binding]; other site 502025016115 active site 502025016116 transcriptional regulator; Provisional; Region: PRK10632 502025016117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025016118 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025016119 putative effector binding pocket; other site 502025016120 dimerization interface [polypeptide binding]; other site 502025016121 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 502025016122 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 502025016123 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 502025016124 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 502025016125 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 502025016126 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 502025016127 active site 502025016128 dimer interface [polypeptide binding]; other site 502025016129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025016130 S-adenosylmethionine binding site [chemical binding]; other site 502025016131 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025016132 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 502025016133 Peptidase C39 family; Region: Peptidase_C39; pfam03412 502025016134 putative active site [active] 502025016135 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 502025016136 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025016137 Walker A/P-loop; other site 502025016138 ATP binding site [chemical binding]; other site 502025016139 Q-loop/lid; other site 502025016140 ABC transporter signature motif; other site 502025016141 Walker B; other site 502025016142 D-loop; other site 502025016143 H-loop/switch region; other site 502025016144 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025016145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 502025016146 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 502025016147 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 502025016148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025016149 Zn2+ binding site [ion binding]; other site 502025016150 Mg2+ binding site [ion binding]; other site 502025016151 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 502025016152 synthetase active site [active] 502025016153 NTP binding site [chemical binding]; other site 502025016154 metal binding site [ion binding]; metal-binding site 502025016155 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 502025016156 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 502025016157 AAA domain; Region: AAA_33; pfam13671 502025016158 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 502025016159 catalytic site [active] 502025016160 G-X2-G-X-G-K; other site 502025016161 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 502025016162 hypothetical protein; Provisional; Region: PRK11820 502025016163 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 502025016164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025016165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016166 ATP binding site [chemical binding]; other site 502025016167 G-X-G motif; other site 502025016168 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016170 active site 502025016171 phosphorylation site [posttranslational modification] 502025016172 intermolecular recognition site; other site 502025016173 dimerization interface [polypeptide binding]; other site 502025016174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 502025016175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025016176 dimer interface [polypeptide binding]; other site 502025016177 phosphorylation site [posttranslational modification] 502025016178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016179 ATP binding site [chemical binding]; other site 502025016180 Mg2+ binding site [ion binding]; other site 502025016181 G-X-G motif; other site 502025016182 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025016183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016184 active site 502025016185 phosphorylation site [posttranslational modification] 502025016186 intermolecular recognition site; other site 502025016187 dimerization interface [polypeptide binding]; other site 502025016188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016189 Walker A motif; other site 502025016190 ATP binding site [chemical binding]; other site 502025016191 Walker B motif; other site 502025016192 arginine finger; other site 502025016193 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 502025016194 TraB family; Region: TraB; pfam01963 502025016195 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 502025016196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025016197 FeS/SAM binding site; other site 502025016198 HEAT repeats; Region: HEAT_2; pfam13646 502025016199 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016200 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016201 active site 502025016202 ATP binding site [chemical binding]; other site 502025016203 substrate binding site [chemical binding]; other site 502025016204 activation loop (A-loop); other site 502025016205 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 502025016206 DNA translocase FtsK; Provisional; Region: PRK10263 502025016207 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 502025016208 thymidylate kinase; Validated; Region: tmk; PRK00698 502025016209 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 502025016210 TMP-binding site; other site 502025016211 ATP-binding site [chemical binding]; other site 502025016212 PilZ domain; Region: PilZ; pfam07238 502025016213 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025016214 protein binding site [polypeptide binding]; other site 502025016215 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025016216 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025016217 catalytic residues [active] 502025016218 Bifunctional nuclease; Region: DNase-RNase; cl00553 502025016219 HEAT repeats; Region: HEAT_2; pfam13646 502025016220 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 502025016221 HEAT repeat; Region: HEAT; pfam02985 502025016222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016223 ATP binding site [chemical binding]; other site 502025016224 Mg2+ binding site [ion binding]; other site 502025016225 G-X-G motif; other site 502025016226 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025016227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016228 active site 502025016229 phosphorylation site [posttranslational modification] 502025016230 intermolecular recognition site; other site 502025016231 dimerization interface [polypeptide binding]; other site 502025016232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016233 Walker A motif; other site 502025016234 ATP binding site [chemical binding]; other site 502025016235 Walker B motif; other site 502025016236 arginine finger; other site 502025016237 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025016238 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 502025016239 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 502025016240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025016241 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025016242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025016243 non-specific DNA binding site [nucleotide binding]; other site 502025016244 salt bridge; other site 502025016245 sequence-specific DNA binding site [nucleotide binding]; other site 502025016246 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 502025016247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025016248 FeS/SAM binding site; other site 502025016249 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 502025016250 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 502025016251 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 502025016252 L-aspartate oxidase; Provisional; Region: PRK06175 502025016253 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 502025016254 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 502025016255 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 502025016256 putative Iron-sulfur protein interface [polypeptide binding]; other site 502025016257 proximal heme binding site [chemical binding]; other site 502025016258 distal heme binding site [chemical binding]; other site 502025016259 putative dimer interface [polypeptide binding]; other site 502025016260 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 502025016261 dimer interface [polypeptide binding]; other site 502025016262 ADP-ribose binding site [chemical binding]; other site 502025016263 active site 502025016264 nudix motif; other site 502025016265 metal binding site [ion binding]; metal-binding site 502025016266 Membrane protein of unknown function; Region: DUF360; pfam04020 502025016267 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 502025016268 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025016269 Protein phosphatase 2C; Region: PP2C; pfam00481 502025016270 active site 502025016271 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016272 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016273 active site 502025016274 ATP binding site [chemical binding]; other site 502025016275 substrate binding site [chemical binding]; other site 502025016276 activation loop (A-loop); other site 502025016277 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025016278 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025016279 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025016280 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 502025016281 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 502025016282 HIGH motif; other site 502025016283 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 502025016284 active site 502025016285 KMSKS motif; other site 502025016286 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 502025016287 tRNA binding surface [nucleotide binding]; other site 502025016288 anticodon binding site; other site 502025016289 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 502025016290 active site 502025016291 DNA polymerase IV; Validated; Region: PRK02406 502025016292 DNA binding site [nucleotide binding] 502025016293 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 502025016294 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 502025016295 DNA methylase; Region: N6_N4_Mtase; pfam01555 502025016296 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025016297 active site 502025016298 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 502025016299 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 502025016300 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 502025016301 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 502025016302 substrate binding site [chemical binding]; other site 502025016303 active site 502025016304 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025016305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016306 active site 502025016307 phosphorylation site [posttranslational modification] 502025016308 intermolecular recognition site; other site 502025016309 dimerization interface [polypeptide binding]; other site 502025016310 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 502025016311 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 502025016312 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025016313 DNA binding residues [nucleotide binding] 502025016314 dimerization interface [polypeptide binding]; other site 502025016315 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 502025016316 PilZ domain; Region: PilZ; cl01260 502025016317 Predicted transcriptional regulators [Transcription]; Region: COG1510 502025016318 Bacterial Ig-like domain; Region: Big_5; pfam13205 502025016319 recombinase A; Provisional; Region: recA; PRK09354 502025016320 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 502025016321 hexamer interface [polypeptide binding]; other site 502025016322 Walker A motif; other site 502025016323 ATP binding site [chemical binding]; other site 502025016324 Walker B motif; other site 502025016325 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 502025016326 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 502025016327 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 502025016328 competence damage-inducible protein A; Provisional; Region: PRK00549 502025016329 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 502025016330 putative MPT binding site; other site 502025016331 Competence-damaged protein; Region: CinA; pfam02464 502025016332 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025016333 active site 502025016334 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 502025016335 metal binding site 2 [ion binding]; metal-binding site 502025016336 putative DNA binding helix; other site 502025016337 metal binding site 1 [ion binding]; metal-binding site 502025016338 dimer interface [polypeptide binding]; other site 502025016339 structural Zn2+ binding site [ion binding]; other site 502025016340 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 502025016341 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016343 active site 502025016344 phosphorylation site [posttranslational modification] 502025016345 intermolecular recognition site; other site 502025016346 dimerization interface [polypeptide binding]; other site 502025016347 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 502025016348 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 502025016349 substrate binding pocket [chemical binding]; other site 502025016350 chain length determination region; other site 502025016351 catalytic residues [active] 502025016352 substrate-Mg2+ binding site; other site 502025016353 aspartate-rich region 1; other site 502025016354 active site lid residues [active] 502025016355 FOG: WD40 repeat [General function prediction only]; Region: COG2319 502025016356 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025016357 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 502025016358 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025016359 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025016360 phosphopeptide binding site; other site 502025016361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 502025016362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 502025016363 metal binding site [ion binding]; metal-binding site 502025016364 active site 502025016365 I-site; other site 502025016366 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025016367 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 502025016368 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 502025016369 N-acetyl-D-glucosamine binding site [chemical binding]; other site 502025016370 catalytic residue [active] 502025016371 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 502025016372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025016373 putative active site [active] 502025016374 heme pocket [chemical binding]; other site 502025016375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025016376 dimer interface [polypeptide binding]; other site 502025016377 phosphorylation site [posttranslational modification] 502025016378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016379 ATP binding site [chemical binding]; other site 502025016380 Mg2+ binding site [ion binding]; other site 502025016381 G-X-G motif; other site 502025016382 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016384 active site 502025016385 phosphorylation site [posttranslational modification] 502025016386 intermolecular recognition site; other site 502025016387 dimerization interface [polypeptide binding]; other site 502025016388 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 502025016389 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 502025016390 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 502025016391 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 502025016392 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 502025016393 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 502025016394 Clp amino terminal domain; Region: Clp_N; pfam02861 502025016395 Clp amino terminal domain; Region: Clp_N; pfam02861 502025016396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016397 Walker A motif; other site 502025016398 ATP binding site [chemical binding]; other site 502025016399 Walker B motif; other site 502025016400 arginine finger; other site 502025016401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016402 Walker A motif; other site 502025016403 ATP binding site [chemical binding]; other site 502025016404 Walker B motif; other site 502025016405 arginine finger; other site 502025016406 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 502025016407 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 502025016408 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025016409 HSP70 interaction site [polypeptide binding]; other site 502025016410 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 502025016411 dimer interface [polypeptide binding]; other site 502025016412 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 502025016413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016414 Walker A motif; other site 502025016415 ATP binding site [chemical binding]; other site 502025016416 Walker B motif; other site 502025016417 arginine finger; other site 502025016418 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 502025016419 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 502025016420 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025016421 catalytic residues [active] 502025016422 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 502025016423 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 502025016424 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 502025016425 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 502025016426 rod shape-determining protein MreC; Provisional; Region: PRK13922 502025016427 rod shape-determining protein MreC; Region: MreC; pfam04085 502025016428 rod shape-determining protein MreB; Provisional; Region: PRK13927 502025016429 MreB and similar proteins; Region: MreB_like; cd10225 502025016430 nucleotide binding site [chemical binding]; other site 502025016431 Mg binding site [ion binding]; other site 502025016432 putative protofilament interaction site [polypeptide binding]; other site 502025016433 RodZ interaction site [polypeptide binding]; other site 502025016434 SurA N-terminal domain; Region: SurA_N_3; cl07813 502025016435 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 502025016436 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 502025016437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025016438 dimer interface [polypeptide binding]; other site 502025016439 conserved gate region; other site 502025016440 putative PBP binding loops; other site 502025016441 ABC-ATPase subunit interface; other site 502025016442 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 502025016443 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 502025016444 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 502025016445 Walker A/P-loop; other site 502025016446 ATP binding site [chemical binding]; other site 502025016447 Q-loop/lid; other site 502025016448 ABC transporter signature motif; other site 502025016449 Walker B; other site 502025016450 D-loop; other site 502025016451 H-loop/switch region; other site 502025016452 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 502025016453 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 502025016454 Walker A/P-loop; other site 502025016455 ATP binding site [chemical binding]; other site 502025016456 Q-loop/lid; other site 502025016457 ABC transporter signature motif; other site 502025016458 Walker B; other site 502025016459 D-loop; other site 502025016460 H-loop/switch region; other site 502025016461 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 502025016462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025016463 dimer interface [polypeptide binding]; other site 502025016464 conserved gate region; other site 502025016465 putative PBP binding loops; other site 502025016466 ABC-ATPase subunit interface; other site 502025016467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 502025016468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 502025016469 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025016470 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 502025016471 Disintegrin; Region: Disintegrin; cl10507 502025016472 Bacterial Ig-like domain; Region: Big_5; pfam13205 502025016473 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 502025016474 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 502025016475 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 502025016476 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 502025016477 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 502025016478 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 502025016479 Ligand binding site; other site 502025016480 oligomer interface; other site 502025016481 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 502025016482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025016483 active site 502025016484 motif I; other site 502025016485 motif II; other site 502025016486 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 502025016487 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 502025016488 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 502025016489 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 502025016490 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 502025016491 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 502025016492 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 502025016493 Vi polysaccharide export ATP-binding protein VexC; Provisional; Region: PRK15177 502025016494 Walker A/P-loop; other site 502025016495 ATP binding site [chemical binding]; other site 502025016496 Q-loop/lid; other site 502025016497 ABC transporter signature motif; other site 502025016498 Walker B; other site 502025016499 D-loop; other site 502025016500 H-loop/switch region; other site 502025016501 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 502025016502 ABC-2 type transporter; Region: ABC2_membrane; cl17235 502025016503 KpsF/GutQ family protein; Region: kpsF; TIGR00393 502025016504 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 502025016505 putative active site [active] 502025016506 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025016507 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 502025016508 Transposase [DNA replication, recombination, and repair]; Region: COG5421 502025016509 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 502025016510 Patatin-like phospholipase; Region: Patatin; pfam01734 502025016511 active site 502025016512 nucleophile elbow; other site 502025016513 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025016514 metal ion-dependent adhesion site (MIDAS); other site 502025016515 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 502025016516 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 502025016517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016518 Walker A motif; other site 502025016519 ATP binding site [chemical binding]; other site 502025016520 Walker B motif; other site 502025016521 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 502025016522 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 502025016523 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 502025016524 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 502025016525 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 502025016526 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 502025016527 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 502025016528 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 502025016529 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 502025016530 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 502025016531 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 502025016532 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 502025016533 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 502025016534 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 502025016535 guanine deaminase; Provisional; Region: PRK09228 502025016536 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025016537 active site 502025016538 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 502025016539 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 502025016540 TfoX N-terminal domain; Region: TfoX_N; pfam04993 502025016541 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 502025016542 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025016543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025016544 S-adenosylmethionine binding site [chemical binding]; other site 502025016545 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 502025016546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016547 Walker A motif; other site 502025016548 ATP binding site [chemical binding]; other site 502025016549 Walker B motif; other site 502025016550 arginine finger; other site 502025016551 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016552 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016553 active site 502025016554 ATP binding site [chemical binding]; other site 502025016555 substrate binding site [chemical binding]; other site 502025016556 activation loop (A-loop); other site 502025016557 AAA ATPase domain; Region: AAA_16; pfam13191 502025016558 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 502025016559 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 502025016560 ATP-grasp domain; Region: ATP-grasp_4; cl17255 502025016561 SNF2 Helicase protein; Region: DUF3670; pfam12419 502025016562 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 502025016563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025016564 ATP binding site [chemical binding]; other site 502025016565 putative Mg++ binding site [ion binding]; other site 502025016566 Peptidase family M48; Region: Peptidase_M48; cl12018 502025016567 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 502025016568 Mechanosensitive ion channel; Region: MS_channel; pfam00924 502025016569 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 502025016570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025016571 dimerization interface [polypeptide binding]; other site 502025016572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025016573 dimer interface [polypeptide binding]; other site 502025016574 phosphorylation site [posttranslational modification] 502025016575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016576 ATP binding site [chemical binding]; other site 502025016577 Mg2+ binding site [ion binding]; other site 502025016578 G-X-G motif; other site 502025016579 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 502025016580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016581 active site 502025016582 phosphorylation site [posttranslational modification] 502025016583 intermolecular recognition site; other site 502025016584 dimerization interface [polypeptide binding]; other site 502025016585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025016586 Walker A motif; other site 502025016587 ATP binding site [chemical binding]; other site 502025016588 Walker B motif; other site 502025016589 arginine finger; other site 502025016590 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025016591 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 502025016592 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 502025016593 Cu(I) binding site [ion binding]; other site 502025016594 magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021 502025016595 Domain of unknown function (DUF368); Region: DUF368; pfam04018 502025016596 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 502025016597 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025016598 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 502025016599 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 502025016600 Low molecular weight phosphatase family; Region: LMWPc; cl00105 502025016601 active site 502025016602 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 502025016603 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 502025016604 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025016605 PilZ domain; Region: PilZ; pfam07238 502025016606 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016608 active site 502025016609 phosphorylation site [posttranslational modification] 502025016610 intermolecular recognition site; other site 502025016611 dimerization interface [polypeptide binding]; other site 502025016612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 502025016613 active site 502025016614 phosphorylation site [posttranslational modification] 502025016615 intermolecular recognition site; other site 502025016616 dimerization interface [polypeptide binding]; other site 502025016617 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 502025016618 proline aminopeptidase P II; Provisional; Region: PRK10879 502025016619 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 502025016620 active site 502025016621 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 502025016622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025016623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016624 active site 502025016625 phosphorylation site [posttranslational modification] 502025016626 intermolecular recognition site; other site 502025016627 dimerization interface [polypeptide binding]; other site 502025016628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025016629 DNA binding site [nucleotide binding] 502025016630 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025016631 PAS domain; Region: PAS; smart00091 502025016632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025016633 dimer interface [polypeptide binding]; other site 502025016634 phosphorylation site [posttranslational modification] 502025016635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016636 ATP binding site [chemical binding]; other site 502025016637 Mg2+ binding site [ion binding]; other site 502025016638 G-X-G motif; other site 502025016639 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 502025016640 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 502025016641 FMN binding site [chemical binding]; other site 502025016642 active site 502025016643 catalytic residues [active] 502025016644 substrate binding site [chemical binding]; other site 502025016645 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 502025016646 GTP binding site; other site 502025016647 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 502025016648 active site 502025016649 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 502025016650 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 502025016651 active site 502025016652 dimerization interface [polypeptide binding]; other site 502025016653 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 502025016654 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 502025016655 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 502025016656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025016657 Coenzyme A binding pocket [chemical binding]; other site 502025016658 PilZ domain; Region: PilZ; cl01260 502025016659 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 502025016660 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025016661 putative active site [active] 502025016662 putative metal binding site [ion binding]; other site 502025016663 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 502025016664 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 502025016665 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025016666 catalytic residue [active] 502025016667 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 502025016668 Cytochrome P450; Region: p450; pfam00067 502025016669 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025016670 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025016671 catalytic residue [active] 502025016672 FcoT-like thioesterase domain; Region: FcoT; pfam10862 502025016673 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 502025016674 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 502025016675 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 502025016676 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 502025016677 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 502025016678 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025016679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025016680 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016681 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016682 active site 502025016683 ATP binding site [chemical binding]; other site 502025016684 substrate binding site [chemical binding]; other site 502025016685 activation loop (A-loop); other site 502025016686 AAA ATPase domain; Region: AAA_16; pfam13191 502025016687 Erythromycin esterase; Region: Erythro_esteras; cl17110 502025016688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025016689 binding surface 502025016690 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025016691 TPR motif; other site 502025016692 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025016693 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025016694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025016695 binding surface 502025016696 TPR motif; other site 502025016697 GAF domain; Region: GAF; pfam01590 502025016698 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025016699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025016700 dimer interface [polypeptide binding]; other site 502025016701 phosphorylation site [posttranslational modification] 502025016702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025016703 ATP binding site [chemical binding]; other site 502025016704 Mg2+ binding site [ion binding]; other site 502025016705 G-X-G motif; other site 502025016706 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 502025016707 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025016708 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025016709 protein binding site [polypeptide binding]; other site 502025016710 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 502025016711 Part of AAA domain; Region: AAA_19; pfam13245 502025016712 Family description; Region: UvrD_C_2; pfam13538 502025016713 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 502025016714 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 502025016715 TolR protein; Region: tolR; TIGR02801 502025016716 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 502025016717 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025016718 TPR repeat; Region: TPR_11; pfam13414 502025016719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025016720 binding surface 502025016721 TPR motif; other site 502025016722 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 502025016723 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 502025016724 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 502025016725 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 502025016726 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 502025016727 dimerization interface [polypeptide binding]; other site 502025016728 active site 502025016729 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 502025016730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 502025016731 motif II; other site 502025016732 CAAX protease self-immunity; Region: Abi; pfam02517 502025016733 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 502025016734 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 502025016735 putative active site; other site 502025016736 catalytic residue [active] 502025016737 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 502025016738 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 502025016739 active site 502025016740 metal binding site [ion binding]; metal-binding site 502025016741 AAA ATPase domain; Region: AAA_16; pfam13191 502025016742 HEAT repeats; Region: HEAT_2; pfam13646 502025016743 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 502025016744 Beta propeller domain; Region: Beta_propel; pfam09826 502025016745 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016746 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016747 active site 502025016748 ATP binding site [chemical binding]; other site 502025016749 substrate binding site [chemical binding]; other site 502025016750 activation loop (A-loop); other site 502025016751 PEGA domain; Region: PEGA; pfam08308 502025016752 Uncharacterized conserved protein [Function unknown]; Region: COG1262 502025016753 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025016754 Ligase N family; Region: LIGANc; smart00532 502025016755 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 502025016756 nucleotide binding pocket [chemical binding]; other site 502025016757 K-X-D-G motif; other site 502025016758 catalytic site [active] 502025016759 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 502025016760 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 502025016761 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 502025016762 Dimer interface [polypeptide binding]; other site 502025016763 Helix-turn-helix domain; Region: HTH_17; cl17695 502025016764 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 502025016765 active site 502025016766 phosphorylation site [posttranslational modification] 502025016767 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 502025016768 active site 502025016769 NTP binding site [chemical binding]; other site 502025016770 metal binding triad [ion binding]; metal-binding site 502025016771 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 502025016772 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025016773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025016774 S-adenosylmethionine binding site [chemical binding]; other site 502025016775 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 502025016776 glycogen binding site [chemical binding]; other site 502025016777 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 502025016778 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 502025016779 nucleotide binding site [chemical binding]; other site 502025016780 putative NEF/HSP70 interaction site [polypeptide binding]; other site 502025016781 SBD interface [polypeptide binding]; other site 502025016782 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016783 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016784 active site 502025016785 ATP binding site [chemical binding]; other site 502025016786 substrate binding site [chemical binding]; other site 502025016787 activation loop (A-loop); other site 502025016788 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 502025016789 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 502025016790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025016791 Walker A/P-loop; other site 502025016792 ATP binding site [chemical binding]; other site 502025016793 Q-loop/lid; other site 502025016794 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 502025016795 ABC transporter signature motif; other site 502025016796 Walker B; other site 502025016797 D-loop; other site 502025016798 ABC transporter; Region: ABC_tran_2; pfam12848 502025016799 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 502025016800 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 502025016801 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 502025016802 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 502025016803 gamma subunit interface [polypeptide binding]; other site 502025016804 epsilon subunit interface [polypeptide binding]; other site 502025016805 LBP interface [polypeptide binding]; other site 502025016806 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 502025016807 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 502025016808 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 502025016809 alpha subunit interaction interface [polypeptide binding]; other site 502025016810 Walker A motif; other site 502025016811 ATP binding site [chemical binding]; other site 502025016812 Walker B motif; other site 502025016813 inhibitor binding site; inhibition site 502025016814 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 502025016815 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 502025016816 core domain interface [polypeptide binding]; other site 502025016817 delta subunit interface [polypeptide binding]; other site 502025016818 epsilon subunit interface [polypeptide binding]; other site 502025016819 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 502025016820 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 502025016821 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 502025016822 beta subunit interaction interface [polypeptide binding]; other site 502025016823 Walker A motif; other site 502025016824 ATP binding site [chemical binding]; other site 502025016825 Walker B motif; other site 502025016826 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 502025016827 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 502025016828 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 502025016829 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 502025016830 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 502025016831 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 502025016832 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 502025016833 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 502025016834 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 502025016835 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016836 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025016837 active site 502025016838 ATP binding site [chemical binding]; other site 502025016839 substrate binding site [chemical binding]; other site 502025016840 activation loop (A-loop); other site 502025016841 PEGA domain; Region: PEGA; pfam08308 502025016842 PEGA domain; Region: PEGA; pfam08308 502025016843 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016845 active site 502025016846 phosphorylation site [posttranslational modification] 502025016847 intermolecular recognition site; other site 502025016848 dimerization interface [polypeptide binding]; other site 502025016849 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 502025016850 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 502025016851 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025016852 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 502025016853 NAD binding site [chemical binding]; other site 502025016854 putative substrate binding site 2 [chemical binding]; other site 502025016855 putative substrate binding site 1 [chemical binding]; other site 502025016856 active site 502025016857 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 502025016858 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 502025016859 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 502025016860 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 502025016861 putative NAD(P) binding site [chemical binding]; other site 502025016862 dimer interface [polypeptide binding]; other site 502025016863 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 502025016864 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 502025016865 Ciliary basal body-associated, B9 protein; Region: B9-C2; pfam07162 502025016866 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 502025016867 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 502025016868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025016869 Walker A/P-loop; other site 502025016870 ATP binding site [chemical binding]; other site 502025016871 Q-loop/lid; other site 502025016872 ABC transporter signature motif; other site 502025016873 Walker B; other site 502025016874 D-loop; other site 502025016875 H-loop/switch region; other site 502025016876 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 502025016877 beta-galactosidase; Region: BGL; TIGR03356 502025016878 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 502025016879 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 502025016880 active site 502025016881 catalytic site [active] 502025016882 substrate binding site [chemical binding]; other site 502025016883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025016884 TPR motif; other site 502025016885 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016886 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016887 active site 502025016888 ATP binding site [chemical binding]; other site 502025016889 substrate binding site [chemical binding]; other site 502025016890 activation loop (A-loop); other site 502025016891 FHA domain; Region: FHA; pfam00498 502025016892 phosphopeptide binding site; other site 502025016893 AAA domain; Region: AAA_28; pfam13521 502025016894 AAA domain; Region: AAA_17; pfam13207 502025016895 Ferritin-like domain; Region: Ferritin_2; pfam13668 502025016896 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025016897 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025016898 active site 502025016899 ATP binding site [chemical binding]; other site 502025016900 substrate binding site [chemical binding]; other site 502025016901 activation loop (A-loop); other site 502025016902 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 502025016903 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 502025016904 active site 502025016905 catalytic motif [active] 502025016906 Zn binding site [ion binding]; other site 502025016907 purine nucleoside phosphorylase; Provisional; Region: PRK08202 502025016908 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 502025016909 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 502025016910 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 502025016911 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 502025016912 phosphopentomutase; Provisional; Region: PRK05362 502025016913 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 502025016914 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 502025016915 intersubunit interface [polypeptide binding]; other site 502025016916 active site 502025016917 catalytic residue [active] 502025016918 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025016919 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025016920 active site 502025016921 catalytic tetrad [active] 502025016922 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 502025016923 glutathione s-transferase; Provisional; Region: PTZ00057 502025016924 GSH binding site (G-site) [chemical binding]; other site 502025016925 C-terminal domain interface [polypeptide binding]; other site 502025016926 dimer interface [polypeptide binding]; other site 502025016927 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025016928 N-terminal domain interface [polypeptide binding]; other site 502025016929 dimer interface [polypeptide binding]; other site 502025016930 substrate binding pocket (H-site) [chemical binding]; other site 502025016931 Uncharacterized conserved protein [Function unknown]; Region: COG0397 502025016932 hypothetical protein; Validated; Region: PRK00029 502025016933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025016934 NAD(P) binding site [chemical binding]; other site 502025016935 NADH(P)-binding; Region: NAD_binding_10; pfam13460 502025016936 active site 502025016937 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 502025016938 Site-specific recombinase; Region: SpecificRecomb; cl15411 502025016939 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 502025016940 dimer interface [polypeptide binding]; other site 502025016941 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025016942 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 502025016943 active site 502025016944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 502025016945 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 502025016946 active site 502025016947 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 502025016948 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 502025016949 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 502025016950 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 502025016951 ABC transporter; Region: ABC_tran_2; pfam12848 502025016952 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 502025016953 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 502025016954 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 502025016955 DNA topoisomerase III; Provisional; Region: PRK07726 502025016956 active site 502025016957 putative interdomain interaction site [polypeptide binding]; other site 502025016958 putative metal-binding site [ion binding]; other site 502025016959 putative nucleotide binding site [chemical binding]; other site 502025016960 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 502025016961 domain I; other site 502025016962 phosphate binding site [ion binding]; other site 502025016963 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 502025016964 domain II; other site 502025016965 domain III; other site 502025016966 nucleotide binding site [chemical binding]; other site 502025016967 DNA binding groove [nucleotide binding] 502025016968 catalytic site [active] 502025016969 domain IV; other site 502025016970 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 502025016971 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 502025016972 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 502025016973 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 502025016974 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 502025016975 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 502025016976 Pirin-related protein [General function prediction only]; Region: COG1741 502025016977 Pirin; Region: Pirin; pfam02678 502025016978 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 502025016979 Integrin, beta chain; Region: Integrin_beta; cl17693 502025016980 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 502025016981 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025016982 metal ion-dependent adhesion site (MIDAS); other site 502025016983 PAS fold; Region: PAS_4; pfam08448 502025016984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025016985 putative active site [active] 502025016986 heme pocket [chemical binding]; other site 502025016987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025016988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 502025016989 dimer interface [polypeptide binding]; other site 502025016990 phosphorylation site [posttranslational modification] 502025016991 Response regulator receiver domain; Region: Response_reg; pfam00072 502025016992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025016993 active site 502025016994 phosphorylation site [posttranslational modification] 502025016995 intermolecular recognition site; other site 502025016996 dimerization interface [polypeptide binding]; other site 502025016997 Uncharacterized conserved protein [Function unknown]; Region: COG1683 502025016998 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 502025016999 propionate/acetate kinase; Provisional; Region: PRK12379 502025017000 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 502025017001 Propanediol utilisation protein PduL; Region: PduL; pfam06130 502025017002 Propanediol utilisation protein PduL; Region: PduL; pfam06130 502025017003 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 502025017004 Methyltransferase domain; Region: Methyltransf_25; pfam13649 502025017005 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 502025017006 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 502025017007 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025017008 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 502025017009 putative nucleotide binding site [chemical binding]; other site 502025017010 uridine monophosphate binding site [chemical binding]; other site 502025017011 homohexameric interface [polypeptide binding]; other site 502025017012 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 502025017013 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 502025017014 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 502025017015 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 502025017016 active site 502025017017 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 502025017018 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 502025017019 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017020 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017021 active site 502025017022 ATP binding site [chemical binding]; other site 502025017023 substrate binding site [chemical binding]; other site 502025017024 activation loop (A-loop); other site 502025017025 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 502025017026 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025017027 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 502025017028 catalytic triad [active] 502025017029 putative active site [active] 502025017030 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 502025017031 Cna protein B-type domain; Region: Cna_B_2; pfam13715 502025017032 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025017033 starch binding outer membrane protein SusD; Region: SusD; cd08977 502025017034 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 502025017035 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025017036 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025017037 DNA binding residues [nucleotide binding] 502025017038 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 502025017039 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 502025017040 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 502025017041 active site 502025017042 catalytic site [active] 502025017043 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 502025017044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025017045 Walker A/P-loop; other site 502025017046 ATP binding site [chemical binding]; other site 502025017047 Q-loop/lid; other site 502025017048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025017049 Walker B; other site 502025017050 D-loop; other site 502025017051 H-loop/switch region; other site 502025017052 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 502025017053 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 502025017054 active site 502025017055 metal binding site [ion binding]; metal-binding site 502025017056 DNA binding site [nucleotide binding] 502025017057 HerA helicase [Replication, recombination, and repair]; Region: COG0433 502025017058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 502025017059 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 502025017060 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 502025017061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025017062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025017063 WHG domain; Region: WHG; pfam13305 502025017064 short chain dehydrogenase; Provisional; Region: PRK06197 502025017065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017066 NAD(P) binding site [chemical binding]; other site 502025017067 active site 502025017068 acetyl-CoA synthetase; Provisional; Region: PRK00174 502025017069 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025017070 acyl-activating enzyme (AAE) consensus motif; other site 502025017071 AMP binding site [chemical binding]; other site 502025017072 active site 502025017073 CoA binding site [chemical binding]; other site 502025017074 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 502025017075 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 502025017076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 502025017077 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 502025017078 active site 502025017079 iron coordination sites [ion binding]; other site 502025017080 substrate binding pocket [chemical binding]; other site 502025017081 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 502025017082 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 502025017083 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 502025017084 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 502025017085 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 502025017086 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 502025017087 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 502025017088 homodimer interface [polypeptide binding]; other site 502025017089 substrate-cofactor binding pocket; other site 502025017090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025017091 catalytic residue [active] 502025017092 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 502025017093 putative ligand binding site [chemical binding]; other site 502025017094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017095 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 502025017096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025017097 Coenzyme A binding pocket [chemical binding]; other site 502025017098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025017099 H+ Antiporter protein; Region: 2A0121; TIGR00900 502025017100 putative substrate translocation pore; other site 502025017101 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 502025017102 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 502025017103 active site 502025017104 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 502025017105 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 502025017106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 502025017107 Coenzyme A binding pocket [chemical binding]; other site 502025017108 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 502025017109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025017110 FeS/SAM binding site; other site 502025017111 H+ Antiporter protein; Region: 2A0121; TIGR00900 502025017112 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 502025017113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 502025017114 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 502025017115 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025017116 inhibitor-cofactor binding pocket; inhibition site 502025017117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025017118 catalytic residue [active] 502025017119 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 502025017120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025017121 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 502025017122 substrate binding site [chemical binding]; other site 502025017123 B12 cofactor binding site [chemical binding]; other site 502025017124 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 502025017125 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 502025017126 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 502025017127 nucleotide binding site [chemical binding]; other site 502025017128 substrate binding site [chemical binding]; other site 502025017129 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 502025017130 B12 binding site [chemical binding]; other site 502025017131 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 502025017132 putative di-iron ligands [ion binding]; other site 502025017133 acyl-CoA synthetase; Validated; Region: PRK05850 502025017134 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 502025017135 acyl-activating enzyme (AAE) consensus motif; other site 502025017136 active site 502025017137 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025017138 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 502025017139 thioester reductase domain; Region: Thioester-redct; TIGR01746 502025017140 putative NAD(P) binding site [chemical binding]; other site 502025017141 active site 502025017142 putative substrate binding site [chemical binding]; other site 502025017143 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 502025017144 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 502025017145 Integrase core domain; Region: rve; pfam00665 502025017146 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 502025017147 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 502025017148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 502025017149 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 502025017150 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 502025017151 dimer interface [polypeptide binding]; other site 502025017152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025017153 catalytic residue [active] 502025017154 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 502025017155 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 502025017156 conserved cys residue [active] 502025017157 Polypeptide deformylase; Region: Pep_deformylase; pfam01327 502025017158 active site 502025017159 catalytic residues [active] 502025017160 metal binding site [ion binding]; metal-binding site 502025017161 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 502025017162 active site 502025017163 Family description; Region: VCBS; pfam13517 502025017164 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 502025017165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017166 Walker A motif; other site 502025017167 ATP binding site [chemical binding]; other site 502025017168 Walker B motif; other site 502025017169 arginine finger; other site 502025017170 Helix-turn-helix domain; Region: HTH_38; pfam13936 502025017171 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017172 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017173 active site 502025017174 ATP binding site [chemical binding]; other site 502025017175 substrate binding site [chemical binding]; other site 502025017176 activation loop (A-loop); other site 502025017177 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017178 substrate binding site [chemical binding]; other site 502025017179 activation loop (A-loop); other site 502025017180 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017181 AAA ATPase domain; Region: AAA_16; pfam13191 502025017182 AAA domain; Region: AAA_22; pfam13401 502025017183 Uncharacterized conserved protein [Function unknown]; Region: COG1262 502025017184 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 502025017185 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 502025017186 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 502025017187 glycogen synthase; Provisional; Region: glgA; PRK00654 502025017188 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 502025017189 ADP-binding pocket [chemical binding]; other site 502025017190 homodimer interface [polypeptide binding]; other site 502025017191 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 502025017192 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025017193 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025017194 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 502025017195 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 502025017196 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 502025017197 active site 502025017198 metal binding site [ion binding]; metal-binding site 502025017199 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025017200 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025017201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025017202 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025017203 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025017204 catalytic residue [active] 502025017205 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 502025017206 translation initiation factor IF-2; Region: IF-2; TIGR00487 502025017207 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 502025017208 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 502025017209 G1 box; other site 502025017210 putative GEF interaction site [polypeptide binding]; other site 502025017211 GTP/Mg2+ binding site [chemical binding]; other site 502025017212 Switch I region; other site 502025017213 G2 box; other site 502025017214 G3 box; other site 502025017215 Switch II region; other site 502025017216 G4 box; other site 502025017217 G5 box; other site 502025017218 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 502025017219 Translation-initiation factor 2; Region: IF-2; pfam11987 502025017220 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 502025017221 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 502025017222 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 502025017223 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017224 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017225 active site 502025017226 ATP binding site [chemical binding]; other site 502025017227 substrate binding site [chemical binding]; other site 502025017228 activation loop (A-loop); other site 502025017229 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 502025017230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025017231 DNA binding residues [nucleotide binding] 502025017232 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025017233 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025017234 classical (c) SDRs; Region: SDR_c; cd05233 502025017235 NAD(P) binding site [chemical binding]; other site 502025017236 active site 502025017237 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 502025017238 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 502025017239 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 502025017240 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 502025017241 ABC1 family; Region: ABC1; pfam03109 502025017242 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017243 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017244 active site 502025017245 ATP binding site [chemical binding]; other site 502025017246 substrate binding site [chemical binding]; other site 502025017247 activation loop (A-loop); other site 502025017248 AAA ATPase domain; Region: AAA_16; pfam13191 502025017249 Predicted ATPase [General function prediction only]; Region: COG3899 502025017250 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025017251 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025017252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025017253 dimer interface [polypeptide binding]; other site 502025017254 phosphorylation site [posttranslational modification] 502025017255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017256 ATP binding site [chemical binding]; other site 502025017257 Mg2+ binding site [ion binding]; other site 502025017258 G-X-G motif; other site 502025017259 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017261 active site 502025017262 phosphorylation site [posttranslational modification] 502025017263 intermolecular recognition site; other site 502025017264 dimerization interface [polypeptide binding]; other site 502025017265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017266 S-adenosylmethionine binding site [chemical binding]; other site 502025017267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017268 S-adenosylmethionine binding site [chemical binding]; other site 502025017269 NlpC/P60 family; Region: NLPC_P60; cl17555 502025017270 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025017271 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025017272 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 502025017273 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025017274 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 502025017275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025017276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025017277 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 502025017278 hydrophobic ligand binding site; other site 502025017279 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 502025017280 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025017281 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 502025017282 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 502025017283 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025017284 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025017285 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017286 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017287 active site 502025017288 ATP binding site [chemical binding]; other site 502025017289 substrate binding site [chemical binding]; other site 502025017290 activation loop (A-loop); other site 502025017291 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025017292 Tetratricopeptide repeat; Region: TPR_10; pfam13374 502025017293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025017294 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025017295 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025017296 binding surface 502025017297 TPR motif; other site 502025017298 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025017299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025017300 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025017301 DNA binding residues [nucleotide binding] 502025017302 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025017303 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 502025017304 DNA binding residues [nucleotide binding] 502025017305 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 502025017306 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 502025017307 homodimer interface [polypeptide binding]; other site 502025017308 ligand binding site I [chemical binding]; other site 502025017309 Ca binding site [ion binding]; other site 502025017310 ligand binding site II [chemical binding]; other site 502025017311 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 502025017312 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 502025017313 active site flap/lid [active] 502025017314 nucleophilic elbow; other site 502025017315 catalytic triad [active] 502025017316 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 502025017317 active site 502025017318 catalytic residues [active] 502025017319 Protein of unknown function (DUF732); Region: DUF732; pfam05305 502025017320 Uncharacterized conserved protein [Function unknown]; Region: COG3791 502025017321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017322 S-adenosylmethionine binding site [chemical binding]; other site 502025017323 Predicted transcriptional regulator [Transcription]; Region: COG1959 502025017324 Transcriptional regulator; Region: Rrf2; pfam02082 502025017325 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 502025017326 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 502025017327 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017329 active site 502025017330 phosphorylation site [posttranslational modification] 502025017331 intermolecular recognition site; other site 502025017332 dimerization interface [polypeptide binding]; other site 502025017333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025017334 dimer interface [polypeptide binding]; other site 502025017335 phosphorylation site [posttranslational modification] 502025017336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017337 ATP binding site [chemical binding]; other site 502025017338 Mg2+ binding site [ion binding]; other site 502025017339 G-X-G motif; other site 502025017340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017341 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017342 active site 502025017343 phosphorylation site [posttranslational modification] 502025017344 intermolecular recognition site; other site 502025017345 dimerization interface [polypeptide binding]; other site 502025017346 PAAR motif; Region: PAAR_motif; pfam05488 502025017347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 502025017348 S-adenosylmethionine binding site [chemical binding]; other site 502025017349 Predicted permease; Region: DUF318; cl17795 502025017350 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 502025017351 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 502025017352 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 502025017353 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 502025017354 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 502025017355 DNA binding site [nucleotide binding] 502025017356 active site 502025017357 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 502025017358 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 502025017359 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 502025017360 PKC phosphorylation site [posttranslational modification]; other site 502025017361 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 502025017362 putative active site [active] 502025017363 putative metal binding site [ion binding]; other site 502025017364 Uncharacterized conserved protein [Function unknown]; Region: COG4279 502025017365 SNF2 Helicase protein; Region: DUF3670; pfam12419 502025017366 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 502025017367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025017368 ATP binding site [chemical binding]; other site 502025017369 putative Mg++ binding site [ion binding]; other site 502025017370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025017371 nucleotide binding region [chemical binding]; other site 502025017372 ATP-binding site [chemical binding]; other site 502025017373 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025017374 protein-splicing catalytic site; other site 502025017375 thioester formation/cholesterol transfer; other site 502025017376 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 502025017377 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025017378 thioester formation/cholesterol transfer; other site 502025017379 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025017380 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025017381 calcium binding site 2 [ion binding]; other site 502025017382 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 502025017383 active site 502025017384 catalytic triad [active] 502025017385 calcium binding site 1 [ion binding]; other site 502025017386 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025017387 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 502025017388 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 502025017389 thioester formation/cholesterol transfer; other site 502025017390 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025017391 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025017392 catalytic residues [active] 502025017393 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025017394 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025017395 catalytic residues [active] 502025017396 Uncharacterized conserved protein [Function unknown]; Region: COG5276 502025017397 LVIVD repeat; Region: LVIVD; pfam08309 502025017398 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 502025017399 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025017400 catalytic residues [active] 502025017401 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 502025017402 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 502025017403 RHS Repeat; Region: RHS_repeat; cl11982 502025017404 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 502025017405 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 502025017406 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 502025017407 DNA binding residues [nucleotide binding] 502025017408 HYR domain; Region: HYR; pfam02494 502025017409 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 502025017410 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 502025017411 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 502025017412 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 502025017413 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 502025017414 chaperone protein DnaJ; Provisional; Region: PRK14294 502025017415 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 502025017416 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 502025017417 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 502025017418 metal binding site [ion binding]; metal-binding site 502025017419 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 502025017420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017421 S-adenosylmethionine binding site [chemical binding]; other site 502025017422 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 502025017423 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 502025017424 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 502025017425 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 502025017426 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 502025017427 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 502025017428 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 502025017429 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 502025017430 dimer interface [polypeptide binding]; other site 502025017431 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 502025017432 active site 502025017433 Fe binding site [ion binding]; other site 502025017434 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 502025017435 AMP-binding enzyme; Region: AMP-binding; pfam00501 502025017436 acyl-activating enzyme (AAE) consensus motif; other site 502025017437 AMP binding site [chemical binding]; other site 502025017438 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 502025017439 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 502025017440 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 502025017441 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025017442 active site 502025017443 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 502025017444 Predicted flavoprotein [General function prediction only]; Region: COG0431 502025017445 Low molecular weight phosphatase family; Region: LMWPc; cd00115 502025017446 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 502025017447 active site 502025017448 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 502025017449 arsenical-resistance protein; Region: acr3; TIGR00832 502025017450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025017451 dimerization interface [polypeptide binding]; other site 502025017452 putative DNA binding site [nucleotide binding]; other site 502025017453 putative Zn2+ binding site [ion binding]; other site 502025017454 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025017455 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025017456 phosphopeptide binding site; other site 502025017457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017458 NmrA-like family; Region: NmrA; pfam05368 502025017459 NAD(P) binding site [chemical binding]; other site 502025017460 active site 502025017461 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017462 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017463 active site 502025017464 ATP binding site [chemical binding]; other site 502025017465 substrate binding site [chemical binding]; other site 502025017466 activation loop (A-loop); other site 502025017467 AAA ATPase domain; Region: AAA_16; pfam13191 502025017468 Uncharacterized conserved protein [Function unknown]; Region: COG1944 502025017469 YcaO-like family; Region: YcaO; pfam02624 502025017470 TfuA-like protein; Region: TfuA; pfam07812 502025017471 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 502025017472 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 502025017473 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 502025017474 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 502025017475 active site 502025017476 Zn binding site [ion binding]; other site 502025017477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 502025017478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 502025017479 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 502025017480 putative effector binding pocket; other site 502025017481 dimerization interface [polypeptide binding]; other site 502025017482 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 502025017483 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 502025017484 potential catalytic triad [active] 502025017485 conserved cys residue [active] 502025017486 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 502025017487 classical (c) SDRs; Region: SDR_c; cd05233 502025017488 NAD(P) binding site [chemical binding]; other site 502025017489 active site 502025017490 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 502025017491 GSH binding site (G-site) [chemical binding]; other site 502025017492 C-terminal domain interface [polypeptide binding]; other site 502025017493 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025017494 dimer interface [polypeptide binding]; other site 502025017495 Glutathione S-transferase, C-terminal domain; Region: GST_C; pfam00043 502025017496 N-terminal domain interface [polypeptide binding]; other site 502025017497 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025017498 BNR repeat-like domain; Region: BNR_2; pfam13088 502025017499 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 502025017500 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025017501 N-terminal plug; other site 502025017502 ligand-binding site [chemical binding]; other site 502025017503 putative chaperone; Provisional; Region: PRK11678 502025017504 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 502025017505 nucleotide binding site [chemical binding]; other site 502025017506 putative NEF/HSP70 interaction site [polypeptide binding]; other site 502025017507 SBD interface [polypeptide binding]; other site 502025017508 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 502025017509 Endonuclease I; Region: Endonuclease_1; cl01003 502025017510 Lamin Tail Domain; Region: LTD; pfam00932 502025017511 Clp protease; Region: CLP_protease; pfam00574 502025017512 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 502025017513 oligomer interface [polypeptide binding]; other site 502025017514 active site residues [active] 502025017515 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 502025017516 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 502025017517 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 502025017518 substrate binding site [chemical binding]; other site 502025017519 ATP binding site [chemical binding]; other site 502025017520 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 502025017521 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017522 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017523 active site 502025017524 substrate binding site [chemical binding]; other site 502025017525 ATP binding site [chemical binding]; other site 502025017526 activation loop (A-loop); other site 502025017527 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 502025017528 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025017529 metal ion-dependent adhesion site (MIDAS); other site 502025017530 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 502025017531 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 502025017532 Putative esterase; Region: Esterase; pfam00756 502025017533 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 502025017534 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 502025017535 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 502025017536 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 502025017537 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 502025017538 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 502025017539 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 502025017540 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 502025017541 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025017542 Walker A motif; other site 502025017543 ATP binding site [chemical binding]; other site 502025017544 Walker B motif; other site 502025017545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025017546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025017547 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 502025017548 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025017549 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025017550 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025017551 Protein export membrane protein; Region: SecD_SecF; cl14618 502025017552 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 502025017553 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 502025017554 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 502025017555 HlyD family secretion protein; Region: HlyD_3; pfam13437 502025017556 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 502025017557 Rhomboid family; Region: Rhomboid; pfam01694 502025017558 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 502025017559 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 502025017560 putative active site; other site 502025017561 catalytic triad [active] 502025017562 putative dimer interface [polypeptide binding]; other site 502025017563 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 502025017564 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 502025017565 Family description; Region: VCBS; pfam13517 502025017566 Family description; Region: VCBS; pfam13517 502025017567 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 502025017568 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 502025017569 active site 502025017570 DNA binding site [nucleotide binding] 502025017571 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 502025017572 DNA binding site [nucleotide binding] 502025017573 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025017574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017575 Walker A motif; other site 502025017576 ATP binding site [chemical binding]; other site 502025017577 Walker B motif; other site 502025017578 arginine finger; other site 502025017579 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025017580 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 502025017581 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 502025017582 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 502025017583 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 502025017584 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 502025017585 SPFH domain / Band 7 family; Region: Band_7; pfam01145 502025017586 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 502025017587 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 502025017588 nudix motif; other site 502025017589 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 502025017590 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 502025017591 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 502025017592 active site 502025017593 catalytic residues [active] 502025017594 DNA binding site [nucleotide binding] 502025017595 Int/Topo IB signature motif; other site 502025017596 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025017597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025017598 non-specific DNA binding site [nucleotide binding]; other site 502025017599 salt bridge; other site 502025017600 sequence-specific DNA binding site [nucleotide binding]; other site 502025017601 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025017602 phosphopeptide binding site; other site 502025017603 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017604 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017605 active site 502025017606 ATP binding site [chemical binding]; other site 502025017607 substrate binding site [chemical binding]; other site 502025017608 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017609 substrate binding site [chemical binding]; other site 502025017610 activation loop (A-loop); other site 502025017611 activation loop (A-loop); other site 502025017612 Uncharacterized conserved protein [Function unknown]; Region: COG3791 502025017613 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 502025017614 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 502025017615 NAD binding site [chemical binding]; other site 502025017616 substrate binding site [chemical binding]; other site 502025017617 homodimer interface [polypeptide binding]; other site 502025017618 active site 502025017619 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 502025017620 metal ion-dependent adhesion site (MIDAS); other site 502025017621 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025017622 active site 502025017623 metal binding site [ion binding]; metal-binding site 502025017624 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; pfam09587 502025017625 Protein kinase domain; Region: Pkinase; pfam00069 502025017626 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017627 active site 502025017628 ATP binding site [chemical binding]; other site 502025017629 substrate binding site [chemical binding]; other site 502025017630 activation loop (A-loop); other site 502025017631 PAS domain S-box; Region: sensory_box; TIGR00229 502025017632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025017633 putative active site [active] 502025017634 heme pocket [chemical binding]; other site 502025017635 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025017636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025017637 dimer interface [polypeptide binding]; other site 502025017638 phosphorylation site [posttranslational modification] 502025017639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025017640 ATP binding site [chemical binding]; other site 502025017641 Mg2+ binding site [ion binding]; other site 502025017642 G-X-G motif; other site 502025017643 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017645 active site 502025017646 phosphorylation site [posttranslational modification] 502025017647 intermolecular recognition site; other site 502025017648 dimerization interface [polypeptide binding]; other site 502025017649 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 502025017650 DNA primase; Validated; Region: dnaG; PRK05667 502025017651 CHC2 zinc finger; Region: zf-CHC2; pfam01807 502025017652 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 502025017653 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 502025017654 active site 502025017655 metal binding site [ion binding]; metal-binding site 502025017656 interdomain interaction site; other site 502025017657 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 502025017658 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 502025017659 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 502025017660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025017661 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 502025017662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025017663 DNA binding residues [nucleotide binding] 502025017664 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025017665 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 502025017666 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 502025017667 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 502025017668 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 502025017669 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 502025017670 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 502025017671 DNA binding residues [nucleotide binding] 502025017672 B12 binding domain; Region: B12-binding_2; pfam02607 502025017673 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 502025017674 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 502025017675 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 502025017676 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 502025017677 dimer interface [polypeptide binding]; other site 502025017678 active site 502025017679 CoA binding pocket [chemical binding]; other site 502025017680 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 502025017681 RNA/DNA hybrid binding site [nucleotide binding]; other site 502025017682 active site 502025017683 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 502025017684 Interdomain contacts; other site 502025017685 Cytokine receptor motif; other site 502025017686 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 502025017687 Outer membrane efflux protein; Region: OEP; pfam02321 502025017688 Outer membrane efflux protein; Region: OEP; pfam02321 502025017689 Predicted membrane protein [Function unknown]; Region: COG2323 502025017690 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 502025017691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025017692 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 502025017693 NAD(P) binding site [chemical binding]; other site 502025017694 active site 502025017695 hypothetical protein; Provisional; Region: PRK01254 502025017696 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 502025017697 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 502025017698 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 502025017699 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 502025017700 amidase catalytic site [active] 502025017701 Zn binding residues [ion binding]; other site 502025017702 substrate binding site [chemical binding]; other site 502025017703 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 502025017704 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 502025017705 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025017706 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025017707 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 502025017708 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 502025017709 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 502025017710 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017711 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017712 active site 502025017713 ATP binding site [chemical binding]; other site 502025017714 substrate binding site [chemical binding]; other site 502025017715 activation loop (A-loop); other site 502025017716 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 502025017717 active site 502025017718 Zn binding site [ion binding]; other site 502025017719 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 502025017720 putative catalytic site [active] 502025017721 putative metal binding site [ion binding]; other site 502025017722 putative phosphate binding site [ion binding]; other site 502025017723 Protein kinase domain; Region: Pkinase; pfam00069 502025017724 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017725 active site 502025017726 ATP binding site [chemical binding]; other site 502025017727 substrate binding site [chemical binding]; other site 502025017728 activation loop (A-loop); other site 502025017729 AAA ATPase domain; Region: AAA_16; pfam13191 502025017730 AAA domain; Region: AAA_22; pfam13401 502025017731 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017732 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017733 active site 502025017734 ATP binding site [chemical binding]; other site 502025017735 substrate binding site [chemical binding]; other site 502025017736 activation loop (A-loop); other site 502025017737 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017738 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 502025017739 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 502025017740 Fatty acid desaturase; Region: FA_desaturase; pfam00487 502025017741 Di-iron ligands [ion binding]; other site 502025017742 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 502025017743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025017744 FeS/SAM binding site; other site 502025017745 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 502025017746 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 502025017747 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025017748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017749 active site 502025017750 phosphorylation site [posttranslational modification] 502025017751 intermolecular recognition site; other site 502025017752 dimerization interface [polypeptide binding]; other site 502025017753 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 502025017754 ABC1 family; Region: ABC1; cl17513 502025017755 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 502025017756 Domain of unknown function (DUF955); Region: DUF955; pfam06114 502025017757 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 502025017758 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 502025017759 malate synthase A; Region: malate_syn_A; TIGR01344 502025017760 active site 502025017761 isocitrate lyase; Provisional; Region: PRK15063 502025017762 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 502025017763 tetramer interface [polypeptide binding]; other site 502025017764 active site 502025017765 Mg2+/Mn2+ binding site [ion binding]; other site 502025017766 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 502025017767 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 502025017768 putative dimer interface [polypeptide binding]; other site 502025017769 5-oxoprolinase; Region: PLN02666 502025017770 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 502025017771 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 502025017772 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 502025017773 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 502025017774 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 502025017775 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 502025017776 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 502025017777 OPT oligopeptide transporter protein; Region: OPT; cl14607 502025017778 putative oligopeptide transporter, OPT family; Region: TIGR00733 502025017779 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 502025017780 PilZ domain; Region: PilZ; cl01260 502025017781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025017782 Response regulator receiver domain; Region: Response_reg; pfam00072 502025017783 active site 502025017784 phosphorylation site [posttranslational modification] 502025017785 intermolecular recognition site; other site 502025017786 dimerization interface [polypeptide binding]; other site 502025017787 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 502025017788 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 502025017789 CysD dimerization site [polypeptide binding]; other site 502025017790 G1 box; other site 502025017791 putative GEF interaction site [polypeptide binding]; other site 502025017792 GTP/Mg2+ binding site [chemical binding]; other site 502025017793 Switch I region; other site 502025017794 G2 box; other site 502025017795 G3 box; other site 502025017796 Switch II region; other site 502025017797 G4 box; other site 502025017798 G5 box; other site 502025017799 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 502025017800 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 502025017801 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 502025017802 active site 502025017803 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 502025017804 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 502025017805 Active Sites [active] 502025017806 putative ATPase subunit of terminase; Provisional; Region: PHA03333 502025017807 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025017808 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025017809 ligand binding site [chemical binding]; other site 502025017810 flexible hinge region; other site 502025017811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025017812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017813 binding surface 502025017814 TPR motif; other site 502025017815 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017816 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017817 active site 502025017818 ATP binding site [chemical binding]; other site 502025017819 substrate binding site [chemical binding]; other site 502025017820 activation loop (A-loop); other site 502025017821 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 502025017822 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 502025017823 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 502025017824 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 502025017825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025017826 ABC transporter signature motif; other site 502025017827 Walker B; other site 502025017828 D-loop; other site 502025017829 H-loop/switch region; other site 502025017830 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 502025017831 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 502025017832 active site 502025017833 catalytic triad [active] 502025017834 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 502025017835 MPT binding site; other site 502025017836 trimer interface [polypeptide binding]; other site 502025017837 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 502025017838 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 502025017839 HIGH motif; other site 502025017840 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 502025017841 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 502025017842 active site 502025017843 KMSKS motif; other site 502025017844 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 502025017845 tRNA binding surface [nucleotide binding]; other site 502025017846 adenylate kinase; Reviewed; Region: adk; PRK00279 502025017847 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 502025017848 AMP-binding site [chemical binding]; other site 502025017849 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 502025017850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025017851 non-specific DNA binding site [nucleotide binding]; other site 502025017852 salt bridge; other site 502025017853 sequence-specific DNA binding site [nucleotide binding]; other site 502025017854 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 502025017855 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025017856 ligand binding site [chemical binding]; other site 502025017857 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 502025017858 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025017859 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 502025017860 substrate binding site [chemical binding]; other site 502025017861 oxyanion hole (OAH) forming residues; other site 502025017862 trimer interface [polypeptide binding]; other site 502025017863 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 502025017864 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 502025017865 NodB motif; other site 502025017866 putative active site [active] 502025017867 putative catalytic site [active] 502025017868 putative Zn binding site [ion binding]; other site 502025017869 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 502025017870 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025017871 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017872 active site 502025017873 ATP binding site [chemical binding]; other site 502025017874 substrate binding site [chemical binding]; other site 502025017875 activation loop (A-loop); other site 502025017876 PEGA domain; Region: PEGA; pfam08308 502025017877 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025017878 enoyl-CoA hydratase; Validated; Region: PRK08139 502025017879 substrate binding site [chemical binding]; other site 502025017880 oxyanion hole (OAH) forming residues; other site 502025017881 trimer interface [polypeptide binding]; other site 502025017882 SCP-2 sterol transfer family; Region: SCP2; pfam02036 502025017883 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 502025017884 CoA-transferase family III; Region: CoA_transf_3; pfam02515 502025017885 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 502025017886 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 502025017887 nucleotide binding site [chemical binding]; other site 502025017888 substrate binding site [chemical binding]; other site 502025017889 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 502025017890 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 502025017891 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017892 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025017893 active site 502025017894 ATP binding site [chemical binding]; other site 502025017895 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025017896 substrate binding site [chemical binding]; other site 502025017897 activation loop (A-loop); other site 502025017898 AAA ATPase domain; Region: AAA_16; pfam13191 502025017899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 502025017900 Integrase core domain; Region: rve; pfam00665 502025017901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017902 Walker A motif; other site 502025017903 ATP binding site [chemical binding]; other site 502025017904 Walker B motif; other site 502025017905 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025017906 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025017907 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025017908 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025017909 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025017910 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025017911 ligand binding site [chemical binding]; other site 502025017912 PSP1 C-terminal conserved region; Region: PSP1; cl00770 502025017913 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 502025017914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025017915 Walker A motif; other site 502025017916 ATP binding site [chemical binding]; other site 502025017917 Walker B motif; other site 502025017918 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 502025017919 arginine finger; other site 502025017920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017921 binding surface 502025017922 TPR motif; other site 502025017923 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025017924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017925 TPR motif; other site 502025017926 binding surface 502025017927 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 502025017928 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 502025017929 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 502025017930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025017931 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 502025017932 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 502025017933 Walker A/P-loop; other site 502025017934 ATP binding site [chemical binding]; other site 502025017935 Q-loop/lid; other site 502025017936 ABC transporter signature motif; other site 502025017937 Walker B; other site 502025017938 D-loop; other site 502025017939 H-loop/switch region; other site 502025017940 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 502025017941 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 502025017942 Peptidase family M1; Region: Peptidase_M1; pfam01433 502025017943 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 502025017944 Zn binding site [ion binding]; other site 502025017945 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 502025017946 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 502025017947 active site 502025017948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017949 TPR motif; other site 502025017950 binding surface 502025017951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017952 binding surface 502025017953 TPR motif; other site 502025017954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017955 binding surface 502025017956 TPR motif; other site 502025017957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025017958 binding surface 502025017959 TPR motif; other site 502025017960 Gram-negative bacterial tonB protein; Region: TonB; cl10048 502025017961 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 502025017962 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 502025017963 SLBB domain; Region: SLBB; pfam10531 502025017964 O-Antigen ligase; Region: Wzy_C; pfam04932 502025017965 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025017966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025017967 S-adenosylmethionine binding site [chemical binding]; other site 502025017968 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 502025017969 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 502025017970 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 502025017971 dimer interface [polypeptide binding]; other site 502025017972 active site 502025017973 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 502025017974 catalytic residues [active] 502025017975 substrate binding site [chemical binding]; other site 502025017976 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025017977 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025017978 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 502025017979 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 502025017980 Radical SAM superfamily; Region: Radical_SAM; pfam04055 502025017981 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025017982 FeS/SAM binding site; other site 502025017983 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 502025017984 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025017985 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025017986 mercuric reductase; Validated; Region: PRK06370 502025017987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025017988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 502025017989 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 502025017990 hypothetical protein; Provisional; Region: PRK11770 502025017991 Domain of unknown function (DUF307); Region: DUF307; pfam03733 502025017992 Domain of unknown function (DUF307); Region: DUF307; pfam03733 502025017993 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 502025017994 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 502025017995 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 502025017996 molybdopterin cofactor binding site; other site 502025017997 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 502025017998 putative molybdopterin cofactor binding site; other site 502025017999 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 502025018000 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 502025018001 metal binding triad [ion binding]; metal-binding site 502025018002 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 502025018003 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 502025018004 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 502025018005 NADP binding site [chemical binding]; other site 502025018006 substrate binding site [chemical binding]; other site 502025018007 active site 502025018008 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 502025018009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 502025018010 FeS/SAM binding site; other site 502025018011 HemN C-terminal domain; Region: HemN_C; pfam06969 502025018012 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 502025018013 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 502025018014 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025018015 acyl-activating enzyme (AAE) consensus motif; other site 502025018016 AMP binding site [chemical binding]; other site 502025018017 active site 502025018018 CoA binding site [chemical binding]; other site 502025018019 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 502025018020 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 502025018021 Amino acid permease; Region: AA_permease; pfam00324 502025018022 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 502025018023 FAD binding domain; Region: FAD_binding_4; pfam01565 502025018024 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 502025018025 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 502025018026 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 502025018027 acyl-activating enzyme (AAE) consensus motif; other site 502025018028 AMP binding site [chemical binding]; other site 502025018029 active site 502025018030 CoA binding site [chemical binding]; other site 502025018031 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 502025018032 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 502025018033 homodimer interface [polypeptide binding]; other site 502025018034 substrate-cofactor binding pocket; other site 502025018035 catalytic residue [active] 502025018036 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 502025018037 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 502025018038 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 502025018039 active site 502025018040 catalytic tetrad [active] 502025018041 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 502025018042 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 502025018043 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 502025018044 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 502025018045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025018046 Walker A motif; other site 502025018047 ATP binding site [chemical binding]; other site 502025018048 Walker B motif; other site 502025018049 arginine finger; other site 502025018050 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 502025018051 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 502025018052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025018053 dimerization interface [polypeptide binding]; other site 502025018054 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025018055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025018056 dimer interface [polypeptide binding]; other site 502025018057 phosphorylation site [posttranslational modification] 502025018058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025018059 ATP binding site [chemical binding]; other site 502025018060 Mg2+ binding site [ion binding]; other site 502025018061 G-X-G motif; other site 502025018062 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018064 active site 502025018065 phosphorylation site [posttranslational modification] 502025018066 intermolecular recognition site; other site 502025018067 dimerization interface [polypeptide binding]; other site 502025018068 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018070 active site 502025018071 phosphorylation site [posttranslational modification] 502025018072 intermolecular recognition site; other site 502025018073 dimerization interface [polypeptide binding]; other site 502025018074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025018075 dimer interface [polypeptide binding]; other site 502025018076 phosphorylation site [posttranslational modification] 502025018077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025018078 ATP binding site [chemical binding]; other site 502025018079 Mg2+ binding site [ion binding]; other site 502025018080 G-X-G motif; other site 502025018081 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 502025018082 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 502025018083 dimer interface [polypeptide binding]; other site 502025018084 active site 502025018085 metal binding site [ion binding]; metal-binding site 502025018086 glutathione binding site [chemical binding]; other site 502025018087 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 502025018088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025018089 ATP binding site [chemical binding]; other site 502025018090 putative Mg++ binding site [ion binding]; other site 502025018091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025018092 nucleotide binding region [chemical binding]; other site 502025018093 ATP-binding site [chemical binding]; other site 502025018094 DEAD/H associated; Region: DEAD_assoc; pfam08494 502025018095 RNA polymerase III subunit RPC82 helix-turn-helix domain; Region: HTH_9; pfam08221 502025018096 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025018097 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025018098 active site 502025018099 ATP binding site [chemical binding]; other site 502025018100 substrate binding site [chemical binding]; other site 502025018101 activation loop (A-loop); other site 502025018102 AAA ATPase domain; Region: AAA_16; pfam13191 502025018103 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 502025018104 glycogen binding site [chemical binding]; other site 502025018105 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 502025018106 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 502025018107 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 502025018108 dimer interface [polypeptide binding]; other site 502025018109 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 502025018110 active site 502025018111 Fe binding site [ion binding]; other site 502025018112 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025018113 maleylacetoacetate isomerase; Region: maiA; TIGR01262 502025018114 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 502025018115 dimer interface [polypeptide binding]; other site 502025018116 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 502025018117 N-terminal domain interface [polypeptide binding]; other site 502025018118 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 502025018119 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 502025018120 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 502025018121 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 502025018122 dimerization interface [polypeptide binding]; other site 502025018123 putative DNA binding site [nucleotide binding]; other site 502025018124 putative Zn2+ binding site [ion binding]; other site 502025018125 AsnC family; Region: AsnC_trans_reg; pfam01037 502025018126 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 502025018127 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 502025018128 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 502025018129 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025018130 active site 502025018131 ATP binding site [chemical binding]; other site 502025018132 substrate binding site [chemical binding]; other site 502025018133 activation loop (A-loop); other site 502025018134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025018135 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 502025018136 GTP cyclohydrolase I; Provisional; Region: PLN03044 502025018137 active site 502025018138 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025018139 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025018140 active site 502025018141 ATP binding site [chemical binding]; other site 502025018142 substrate binding site [chemical binding]; other site 502025018143 activation loop (A-loop); other site 502025018144 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 502025018145 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 502025018146 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 502025018147 Methyltransferase domain; Region: Methyltransf_26; pfam13659 502025018148 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 502025018149 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025018150 active site 502025018151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025018152 S-adenosylmethionine binding site [chemical binding]; other site 502025018153 Acylphosphatase; Region: Acylphosphatase; pfam00708 502025018154 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 502025018155 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 502025018156 active site 502025018157 metal binding site [ion binding]; metal-binding site 502025018158 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 502025018159 peptide chain release factor 1; Validated; Region: prfA; PRK00591 502025018160 This domain is found in peptide chain release factors; Region: PCRF; smart00937 502025018161 RF-1 domain; Region: RF-1; pfam00472 502025018162 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025018163 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025018164 catalytic residues [active] 502025018165 Thioredoxin; Region: Thioredoxin_4; cl17273 502025018166 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 502025018167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025018168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025018169 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 502025018170 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 502025018171 Ligand binding site [chemical binding]; other site 502025018172 Electron transfer flavoprotein domain; Region: ETF; pfam01012 502025018173 Electron transfer flavoprotein domain; Region: ETF; pfam01012 502025018174 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 502025018175 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 502025018176 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 502025018177 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 502025018178 MoxR-like ATPases [General function prediction only]; Region: COG0714 502025018179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025018180 Walker A motif; other site 502025018181 ATP binding site [chemical binding]; other site 502025018182 Walker B motif; other site 502025018183 arginine finger; other site 502025018184 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 502025018185 Protein of unknown function DUF58; Region: DUF58; pfam01882 502025018186 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 502025018187 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 502025018188 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 502025018189 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 502025018190 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 502025018191 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 502025018192 ring oligomerisation interface [polypeptide binding]; other site 502025018193 ATP/Mg binding site [chemical binding]; other site 502025018194 stacking interactions; other site 502025018195 hinge regions; other site 502025018196 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 502025018197 oligomerisation interface [polypeptide binding]; other site 502025018198 mobile loop; other site 502025018199 roof hairpin; other site 502025018200 PAS fold; Region: PAS_3; pfam08447 502025018201 PAS fold; Region: PAS_4; pfam08448 502025018202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025018203 putative active site [active] 502025018204 heme pocket [chemical binding]; other site 502025018205 PAS domain S-box; Region: sensory_box; TIGR00229 502025018206 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025018207 putative active site [active] 502025018208 heme pocket [chemical binding]; other site 502025018209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 502025018210 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 502025018211 putative active site [active] 502025018212 heme pocket [chemical binding]; other site 502025018213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025018214 dimer interface [polypeptide binding]; other site 502025018215 phosphorylation site [posttranslational modification] 502025018216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025018217 ATP binding site [chemical binding]; other site 502025018218 Mg2+ binding site [ion binding]; other site 502025018219 G-X-G motif; other site 502025018220 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018222 active site 502025018223 phosphorylation site [posttranslational modification] 502025018224 intermolecular recognition site; other site 502025018225 dimerization interface [polypeptide binding]; other site 502025018226 selenophosphate synthetase; Provisional; Region: PRK00943 502025018227 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 502025018228 dimerization interface [polypeptide binding]; other site 502025018229 putative ATP binding site [chemical binding]; other site 502025018230 ferredoxin-NADP+ reductase; Region: PLN02852 502025018231 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025018232 Chorismate mutase type II; Region: CM_2; smart00830 502025018233 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 502025018234 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 502025018235 prephenate dehydrogenase; Validated; Region: PRK08507 502025018236 Uncharacterized conserved protein [Function unknown]; Region: COG0398 502025018237 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 502025018238 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 502025018239 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 502025018240 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 502025018241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 502025018242 dimer interface [polypeptide binding]; other site 502025018243 conserved gate region; other site 502025018244 putative PBP binding loops; other site 502025018245 ABC-ATPase subunit interface; other site 502025018246 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 502025018247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 502025018248 Walker A/P-loop; other site 502025018249 ATP binding site [chemical binding]; other site 502025018250 Q-loop/lid; other site 502025018251 ABC transporter signature motif; other site 502025018252 Walker B; other site 502025018253 D-loop; other site 502025018254 H-loop/switch region; other site 502025018255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025018256 non-specific DNA binding site [nucleotide binding]; other site 502025018257 salt bridge; other site 502025018258 sequence-specific DNA binding site [nucleotide binding]; other site 502025018259 hypothetical protein; Provisional; Region: PRK08609 502025018260 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 502025018261 active site 502025018262 primer binding site [nucleotide binding]; other site 502025018263 NTP binding site [chemical binding]; other site 502025018264 metal binding triad [ion binding]; metal-binding site 502025018265 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 502025018266 active site 502025018267 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025018268 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025018269 protein binding site [polypeptide binding]; other site 502025018270 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 502025018271 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 502025018272 substrate binding site [chemical binding]; other site 502025018273 glutamase interaction surface [polypeptide binding]; other site 502025018274 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 502025018275 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 502025018276 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 502025018277 metal binding site [ion binding]; metal-binding site 502025018278 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 502025018279 DEAD/DEAH box helicase; Region: DEAD; pfam00270 502025018280 DEAD_2; Region: DEAD_2; pfam06733 502025018281 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 502025018282 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 502025018283 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 502025018284 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 502025018285 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 502025018286 G1 box; other site 502025018287 putative GEF interaction site [polypeptide binding]; other site 502025018288 GTP/Mg2+ binding site [chemical binding]; other site 502025018289 Switch I region; other site 502025018290 G2 box; other site 502025018291 G3 box; other site 502025018292 Switch II region; other site 502025018293 G4 box; other site 502025018294 G5 box; other site 502025018295 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 502025018296 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 502025018297 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 502025018298 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 502025018299 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 502025018300 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 502025018301 substrate-cofactor binding pocket; other site 502025018302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025018303 catalytic residue [active] 502025018304 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 502025018305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025018306 NAD(P) binding site [chemical binding]; other site 502025018307 active site 502025018308 Lamin Tail Domain; Region: LTD; pfam00932 502025018309 Bacterial Ig-like domain; Region: Big_5; pfam13205 502025018310 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 502025018311 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 502025018312 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 502025018313 putative active site [active] 502025018314 catalytic site [active] 502025018315 putative metal binding site [ion binding]; other site 502025018316 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 502025018317 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 502025018318 putative ligand binding site [chemical binding]; other site 502025018319 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 502025018320 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 502025018321 Walker A/P-loop; other site 502025018322 ATP binding site [chemical binding]; other site 502025018323 Q-loop/lid; other site 502025018324 ABC transporter signature motif; other site 502025018325 Walker B; other site 502025018326 D-loop; other site 502025018327 H-loop/switch region; other site 502025018328 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 502025018329 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 502025018330 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 502025018331 TM-ABC transporter signature motif; other site 502025018332 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 502025018333 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025018334 catalytic triad [active] 502025018335 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 502025018336 NlpC/P60 family; Region: NLPC_P60; cl17555 502025018337 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 502025018338 nucleotide binding site [chemical binding]; other site 502025018339 Tir chaperone protein (CesT) family; Region: CesT; cl08444 502025018340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 502025018341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 502025018342 Leptospira porin protein OmpL1; Region: Porin_OmpL1; pfam11389 502025018343 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 502025018344 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 502025018345 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 502025018346 nudix motif; other site 502025018347 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 502025018348 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 502025018349 inhibitor-cofactor binding pocket; inhibition site 502025018350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025018351 catalytic residue [active] 502025018352 CsbD-like; Region: CsbD; cl17424 502025018353 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025018354 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 502025018355 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025018356 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 502025018357 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 502025018358 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025018359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025018360 protein binding site [polypeptide binding]; other site 502025018361 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; pfam10092 502025018362 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 502025018363 phosphoglucomutase; Validated; Region: PRK07564 502025018364 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 502025018365 active site 502025018366 substrate binding site [chemical binding]; other site 502025018367 metal binding site [ion binding]; metal-binding site 502025018368 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 502025018369 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 502025018370 catalytic triad [active] 502025018371 dimer interface [polypeptide binding]; other site 502025018372 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 502025018373 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 502025018374 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 502025018375 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 502025018376 active site 502025018377 HIGH motif; other site 502025018378 nucleotide binding site [chemical binding]; other site 502025018379 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 502025018380 KMSKS motif; other site 502025018381 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 502025018382 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025018383 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025018384 active site 502025018385 ATP binding site [chemical binding]; other site 502025018386 substrate binding site [chemical binding]; other site 502025018387 activation loop (A-loop); other site 502025018388 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025018389 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025018390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018391 binding surface 502025018392 TPR motif; other site 502025018393 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025018394 Ligand Binding Site [chemical binding]; other site 502025018395 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 502025018396 Ligand Binding Site [chemical binding]; other site 502025018397 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 502025018398 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 502025018399 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 502025018400 Substrate binding site; other site 502025018401 Mg++ binding site; other site 502025018402 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 502025018403 active site 502025018404 substrate binding site [chemical binding]; other site 502025018405 CoA binding site [chemical binding]; other site 502025018406 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 502025018407 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025018408 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025018409 active site 502025018410 ATP binding site [chemical binding]; other site 502025018411 substrate binding site [chemical binding]; other site 502025018412 activation loop (A-loop); other site 502025018413 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025018414 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025018415 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025018416 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 502025018417 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 502025018418 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 502025018419 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025018420 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025018421 active site 502025018422 ATP binding site [chemical binding]; other site 502025018423 substrate binding site [chemical binding]; other site 502025018424 activation loop (A-loop); other site 502025018425 allantoate amidohydrolase; Reviewed; Region: PRK09290 502025018426 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 502025018427 active site 502025018428 metal binding site [ion binding]; metal-binding site 502025018429 dimer interface [polypeptide binding]; other site 502025018430 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 502025018431 PGAP1-like protein; Region: PGAP1; pfam07819 502025018432 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 502025018433 sugar binding site [chemical binding]; other site 502025018434 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 502025018435 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 502025018436 sugar binding site [chemical binding]; other site 502025018437 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 502025018438 aconitate hydratase; Validated; Region: PRK09277 502025018439 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 502025018440 substrate binding site [chemical binding]; other site 502025018441 ligand binding site [chemical binding]; other site 502025018442 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 502025018443 substrate binding site [chemical binding]; other site 502025018444 Ion transport protein; Region: Ion_trans; pfam00520 502025018445 Ion channel; Region: Ion_trans_2; pfam07885 502025018446 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 502025018447 ribonuclease D; Region: rnd; TIGR01388 502025018448 putative active site [active] 502025018449 putative substrate binding site [chemical binding]; other site 502025018450 catalytic site [active] 502025018451 HRDC domain; Region: HRDC; pfam00570 502025018452 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 502025018453 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 502025018454 P loop; other site 502025018455 Nucleotide binding site [chemical binding]; other site 502025018456 DTAP/Switch II; other site 502025018457 Switch I; other site 502025018458 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 502025018459 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 502025018460 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 502025018461 carboxyltransferase (CT) interaction site; other site 502025018462 biotinylation site [posttranslational modification]; other site 502025018463 CotH protein; Region: CotH; pfam08757 502025018464 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 502025018465 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 502025018466 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 502025018467 protein binding site [polypeptide binding]; other site 502025018468 Cytochrome c; Region: Cytochrom_C; pfam00034 502025018469 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 502025018470 BON domain; Region: BON; pfam04972 502025018471 BON domain; Region: BON; pfam04972 502025018472 BON domain; Region: BON; pfam04972 502025018473 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 502025018474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025018475 ATP binding site [chemical binding]; other site 502025018476 putative Mg++ binding site [ion binding]; other site 502025018477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025018478 nucleotide binding region [chemical binding]; other site 502025018479 ATP-binding site [chemical binding]; other site 502025018480 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 502025018481 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 502025018482 active site 502025018483 Zn binding site [ion binding]; other site 502025018484 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018486 active site 502025018487 phosphorylation site [posttranslational modification] 502025018488 intermolecular recognition site; other site 502025018489 dimerization interface [polypeptide binding]; other site 502025018490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025018491 phosphorylation site [posttranslational modification] 502025018492 dimer interface [polypeptide binding]; other site 502025018493 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 502025018494 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025018495 activation loop (A-loop); other site 502025018496 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025018497 AAA ATPase domain; Region: AAA_16; pfam13191 502025018498 Predicted ATPase [General function prediction only]; Region: COG3899 502025018499 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 502025018500 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 502025018501 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 502025018502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025018503 ATP binding site [chemical binding]; other site 502025018504 Mg2+ binding site [ion binding]; other site 502025018505 G-X-G motif; other site 502025018506 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 502025018507 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 502025018508 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 502025018509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 502025018510 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 502025018511 substrate binding site [chemical binding]; other site 502025018512 oxyanion hole (OAH) forming residues; other site 502025018513 trimer interface [polypeptide binding]; other site 502025018514 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 502025018515 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 502025018516 dimer interface [polypeptide binding]; other site 502025018517 active site 502025018518 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 502025018519 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025018520 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025018521 calcium binding site 2 [ion binding]; other site 502025018522 active site 502025018523 catalytic triad [active] 502025018524 calcium binding site 1 [ion binding]; other site 502025018525 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 502025018526 PKC phosphorylation site [posttranslational modification]; other site 502025018527 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 502025018528 ligand binding site [chemical binding]; other site 502025018529 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 502025018530 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 502025018531 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 502025018532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018533 active site 502025018534 phosphorylation site [posttranslational modification] 502025018535 intermolecular recognition site; other site 502025018536 dimerization interface [polypeptide binding]; other site 502025018537 PilZ domain; Region: PilZ; pfam07238 502025018538 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 502025018539 anti sigma factor interaction site; other site 502025018540 regulatory phosphorylation site [posttranslational modification]; other site 502025018541 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 502025018542 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 502025018543 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 502025018544 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 502025018545 homodimer interface [polypeptide binding]; other site 502025018546 substrate-cofactor binding pocket; other site 502025018547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025018548 catalytic residue [active] 502025018549 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 502025018550 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025018551 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025018552 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025018553 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025018554 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 502025018555 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025018556 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025018557 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 502025018558 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025018559 Uncharacterized conserved protein [Function unknown]; Region: COG3391 502025018560 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025018561 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025018562 phosphopeptide binding site; other site 502025018563 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 502025018564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025018565 Walker A motif; other site 502025018566 ATP binding site [chemical binding]; other site 502025018567 Walker B motif; other site 502025018568 arginine finger; other site 502025018569 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 502025018570 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 502025018571 calcium binding site 2 [ion binding]; other site 502025018572 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 502025018573 active site 502025018574 catalytic triad [active] 502025018575 calcium binding site 1 [ion binding]; other site 502025018576 Somatomedin B domain; Region: Somatomedin_B; pfam01033 502025018577 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 502025018578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 502025018579 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 502025018580 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 502025018581 active site 502025018582 dimer interface [polypeptide binding]; other site 502025018583 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 502025018584 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 502025018585 active site 502025018586 FMN binding site [chemical binding]; other site 502025018587 substrate binding site [chemical binding]; other site 502025018588 3Fe-4S cluster binding site [ion binding]; other site 502025018589 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 502025018590 domain interface; other site 502025018591 Found in ATP-dependent protease La (LON); Region: LON; smart00464 502025018592 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 502025018593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025018594 Walker A motif; other site 502025018595 ATP binding site [chemical binding]; other site 502025018596 Walker B motif; other site 502025018597 arginine finger; other site 502025018598 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 502025018599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025018600 Methyltransferase domain; Region: Methyltransf_31; pfam13847 502025018601 S-adenosylmethionine binding site [chemical binding]; other site 502025018602 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 502025018603 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 502025018604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025018605 S-adenosylmethionine binding site [chemical binding]; other site 502025018606 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 502025018607 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 502025018608 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 502025018609 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 502025018610 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 502025018611 N-terminal plug; other site 502025018612 ligand-binding site [chemical binding]; other site 502025018613 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 502025018614 Galactose oxidase, central domain; Region: Kelch_3; cl02701 502025018615 Galactose oxidase, central domain; Region: Kelch_3; cl02701 502025018616 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 502025018617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025018618 ATP binding site [chemical binding]; other site 502025018619 Mg2+ binding site [ion binding]; other site 502025018620 G-X-G motif; other site 502025018621 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018623 active site 502025018624 phosphorylation site [posttranslational modification] 502025018625 intermolecular recognition site; other site 502025018626 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 502025018627 circadian clock protein KaiC; Reviewed; Region: PRK09302 502025018628 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025018629 Walker A motif; other site 502025018630 ATP binding site [chemical binding]; other site 502025018631 Walker B motif; other site 502025018632 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 502025018633 Walker A motif; other site 502025018634 ATP binding site [chemical binding]; other site 502025018635 Walker B motif; other site 502025018636 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 502025018637 MgtE intracellular N domain; Region: MgtE_N; pfam03448 502025018638 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 502025018639 Divalent cation transporter; Region: MgtE; pfam01769 502025018640 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 502025018641 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 502025018642 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 502025018643 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 502025018644 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 502025018645 putative active site [active] 502025018646 putative metal binding site [ion binding]; other site 502025018647 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 502025018648 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 502025018649 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 502025018650 TM-ABC transporter signature motif; other site 502025018651 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 502025018652 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 502025018653 TM-ABC transporter signature motif; other site 502025018654 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 502025018655 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 502025018656 Walker A/P-loop; other site 502025018657 ATP binding site [chemical binding]; other site 502025018658 Q-loop/lid; other site 502025018659 ABC transporter signature motif; other site 502025018660 Walker B; other site 502025018661 D-loop; other site 502025018662 H-loop/switch region; other site 502025018663 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 502025018664 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 502025018665 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 502025018666 ligand binding site [chemical binding]; other site 502025018667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025018668 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025018669 DNA binding site [nucleotide binding] 502025018670 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 502025018671 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 502025018672 tetrameric interface [polypeptide binding]; other site 502025018673 NAD binding site [chemical binding]; other site 502025018674 catalytic residues [active] 502025018675 SMUG: single-strand-selective monofunctional uracil-DNA glycosylase; Region: UDG_F3_SMUG; cd10029 502025018676 active site 502025018677 substrate specificity residue; other site 502025018678 DNA binding site [nucleotide binding] 502025018679 Prokaryotic RING finger family 4; Region: Prok-RING_4; pfam14447 502025018680 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 502025018681 putative metal binding site [ion binding]; other site 502025018682 Methyltransferase domain; Region: Methyltransf_23; pfam13489 502025018683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025018684 S-adenosylmethionine binding site [chemical binding]; other site 502025018685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025018686 S-adenosylmethionine binding site [chemical binding]; other site 502025018687 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 502025018688 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025018689 catalytic residue [active] 502025018690 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 502025018691 dimer interface [polypeptide binding]; other site 502025018692 putative CheW interface [polypeptide binding]; other site 502025018693 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 502025018694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 502025018695 NAD(P) binding site [chemical binding]; other site 502025018696 active site 502025018697 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025018698 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025018699 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025018700 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025018701 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025018702 FG-GAP repeat; Region: FG-GAP_2; pfam14312 502025018703 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025018704 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025018705 active site 502025018706 ATP binding site [chemical binding]; other site 502025018707 substrate binding site [chemical binding]; other site 502025018708 activation loop (A-loop); other site 502025018709 PEGA domain; Region: PEGA; pfam08308 502025018710 TPR repeat; Region: TPR_11; pfam13414 502025018711 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 502025018712 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 502025018713 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 502025018714 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 502025018715 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 502025018716 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025018717 active site 502025018718 substrate binding site [chemical binding]; other site 502025018719 ATP binding site [chemical binding]; other site 502025018720 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 502025018721 substrate binding site [chemical binding]; other site 502025018722 activation loop (A-loop); other site 502025018723 Tetratricopeptide repeat; Region: TPR_12; pfam13424 502025018724 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 502025018725 Amidohydrolase; Region: Amidohydro_4; pfam13147 502025018726 active site 502025018727 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 502025018728 Amidohydrolase family; Region: Amidohydro_3; pfam07969 502025018729 active site 502025018730 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 502025018731 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 502025018732 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 502025018733 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 502025018734 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 502025018735 GatB domain; Region: GatB_Yqey; smart00845 502025018736 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 502025018737 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 502025018738 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 502025018739 Transcriptional regulators [Transcription]; Region: FadR; COG2186 502025018740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 502025018741 DNA-binding site [nucleotide binding]; DNA binding site 502025018742 FadR C-terminal domain; Region: FadR_C; pfam07840 502025018743 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 502025018744 HSP70 interaction site [polypeptide binding]; other site 502025018745 Tetratricopeptide repeat; Region: TPR_2; pfam07719 502025018746 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025018747 active site 502025018748 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 502025018749 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 502025018750 active site 502025018751 Substrate binding site; other site 502025018752 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 502025018753 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025018754 RNA binding surface [nucleotide binding]; other site 502025018755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025018756 S-adenosylmethionine binding site [chemical binding]; other site 502025018757 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 502025018758 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 502025018759 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 502025018760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018761 active site 502025018762 phosphorylation site [posttranslational modification] 502025018763 intermolecular recognition site; other site 502025018764 dimerization interface [polypeptide binding]; other site 502025018765 PilZ domain; Region: PilZ; cl01260 502025018766 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018768 active site 502025018769 phosphorylation site [posttranslational modification] 502025018770 intermolecular recognition site; other site 502025018771 dimerization interface [polypeptide binding]; other site 502025018772 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018774 active site 502025018775 phosphorylation site [posttranslational modification] 502025018776 intermolecular recognition site; other site 502025018777 dimerization interface [polypeptide binding]; other site 502025018778 Hpt domain; Region: Hpt; pfam01627 502025018779 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018781 active site 502025018782 phosphorylation site [posttranslational modification] 502025018783 intermolecular recognition site; other site 502025018784 dimerization interface [polypeptide binding]; other site 502025018785 CheW-like domain; Region: CheW; pfam01584 502025018786 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 502025018787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 502025018788 dimer interface [polypeptide binding]; other site 502025018789 putative CheW interface [polypeptide binding]; other site 502025018790 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 502025018791 putative binding surface; other site 502025018792 active site 502025018793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025018794 ATP binding site [chemical binding]; other site 502025018795 Mg2+ binding site [ion binding]; other site 502025018796 G-X-G motif; other site 502025018797 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 502025018798 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025018799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018800 active site 502025018801 phosphorylation site [posttranslational modification] 502025018802 intermolecular recognition site; other site 502025018803 dimerization interface [polypeptide binding]; other site 502025018804 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 502025018805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018806 active site 502025018807 phosphorylation site [posttranslational modification] 502025018808 intermolecular recognition site; other site 502025018809 dimerization interface [polypeptide binding]; other site 502025018810 CheB methylesterase; Region: CheB_methylest; pfam01339 502025018811 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 502025018812 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 502025018813 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 502025018814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018815 binding surface 502025018816 TPR motif; other site 502025018817 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 502025018818 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 502025018819 Catalytic domain of Protein Kinases; Region: PKc; cd00180 502025018820 active site 502025018821 ATP binding site [chemical binding]; other site 502025018822 substrate binding site [chemical binding]; other site 502025018823 activation loop (A-loop); other site 502025018824 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 502025018825 BNR repeat-like domain; Region: BNR_2; pfam13088 502025018826 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 502025018827 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 502025018828 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 502025018829 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 502025018830 tRNA; other site 502025018831 putative tRNA binding site [nucleotide binding]; other site 502025018832 putative NADP binding site [chemical binding]; other site 502025018833 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 502025018834 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 502025018835 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 502025018836 domain interfaces; other site 502025018837 active site 502025018838 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 502025018839 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 502025018840 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 502025018841 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 502025018842 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 502025018843 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025018844 ligand binding site [chemical binding]; other site 502025018845 flexible hinge region; other site 502025018846 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 502025018847 peptidase domain interface [polypeptide binding]; other site 502025018848 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 502025018849 active site 502025018850 catalytic triad [active] 502025018851 calcium binding site [ion binding]; other site 502025018852 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 502025018853 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 502025018854 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 502025018855 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 502025018856 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 502025018857 generic binding surface II; other site 502025018858 generic binding surface I; other site 502025018859 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 502025018860 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 502025018861 active site 502025018862 HIGH motif; other site 502025018863 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 502025018864 KMSKS motif; other site 502025018865 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 502025018866 tRNA binding surface [nucleotide binding]; other site 502025018867 anticodon binding site; other site 502025018868 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 502025018869 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 502025018870 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 502025018871 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 502025018872 Zn2+ binding site [ion binding]; other site 502025018873 Mg2+ binding site [ion binding]; other site 502025018874 Methyltransferase domain; Region: Methyltransf_26; pfam13659 502025018875 Protein of unknown function (DUF971); Region: DUF971; pfam06155 502025018876 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 502025018877 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 502025018878 putative molybdopterin cofactor binding site [chemical binding]; other site 502025018879 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 502025018880 putative molybdopterin cofactor binding site; other site 502025018881 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 502025018882 active site 502025018883 substrate binding sites [chemical binding]; other site 502025018884 PEGA domain; Region: PEGA; pfam08308 502025018885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 502025018886 dimerization interface [polypeptide binding]; other site 502025018887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025018888 dimer interface [polypeptide binding]; other site 502025018889 phosphorylation site [posttranslational modification] 502025018890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025018891 ATP binding site [chemical binding]; other site 502025018892 Mg2+ binding site [ion binding]; other site 502025018893 G-X-G motif; other site 502025018894 haloalkane dehalogenase; Provisional; Region: PRK03592 502025018895 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 502025018896 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025018897 P-loop; other site 502025018898 Magnesium ion binding site [ion binding]; other site 502025018899 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 502025018900 Magnesium ion binding site [ion binding]; other site 502025018901 Response regulator receiver domain; Region: Response_reg; pfam00072 502025018902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025018903 active site 502025018904 phosphorylation site [posttranslational modification] 502025018905 intermolecular recognition site; other site 502025018906 dimerization interface [polypeptide binding]; other site 502025018907 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025018908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 502025018909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 502025018910 dimer interface [polypeptide binding]; other site 502025018911 phosphorylation site [posttranslational modification] 502025018912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 502025018913 ATP binding site [chemical binding]; other site 502025018914 Mg2+ binding site [ion binding]; other site 502025018915 G-X-G motif; other site 502025018916 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 502025018917 substrate binding site [chemical binding]; other site 502025018918 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 502025018919 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 502025018920 RNA binding surface [nucleotide binding]; other site 502025018921 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 502025018922 active site 502025018923 tyramine oxidase; Provisional; Region: tynA; PRK11504 502025018924 DEAD-like helicases superfamily; Region: DEXDc; smart00487 502025018925 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 502025018926 ATP binding site [chemical binding]; other site 502025018927 putative Mg++ binding site [ion binding]; other site 502025018928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 502025018929 nucleotide binding region [chemical binding]; other site 502025018930 ATP-binding site [chemical binding]; other site 502025018931 RQC domain; Region: RQC; cl09632 502025018932 HRDC domain; Region: HRDC; pfam00570 502025018933 Predicted permease; Region: DUF318; cl17795 502025018934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025018935 non-specific DNA binding site [nucleotide binding]; other site 502025018936 salt bridge; other site 502025018937 sequence-specific DNA binding site [nucleotide binding]; other site 502025018938 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 502025018939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 502025018940 non-specific DNA binding site [nucleotide binding]; other site 502025018941 salt bridge; other site 502025018942 sequence-specific DNA binding site [nucleotide binding]; other site 502025018943 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 502025018944 TPR repeat; Region: TPR_11; pfam13414 502025018945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018946 binding surface 502025018947 TPR motif; other site 502025018948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025018949 binding surface 502025018950 TPR motif; other site 502025018951 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 502025018952 SmpB-tmRNA interface; other site 502025018953 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 502025018954 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 502025018955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025018956 Walker A motif; other site 502025018957 ATP binding site [chemical binding]; other site 502025018958 Walker B motif; other site 502025018959 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 502025018960 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025018961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 502025018962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 502025018963 DNA binding site [nucleotide binding] 502025018964 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 502025018965 MgtE intracellular N domain; Region: MgtE_N; smart00924 502025018966 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 502025018967 Divalent cation transporter; Region: MgtE; cl00786 502025018968 Protein phosphatase 2C; Region: PP2C; pfam00481 502025018969 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 502025018970 active site 502025018971 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 502025018972 ligand binding site [chemical binding]; other site 502025018973 flexible hinge region; other site 502025018974 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 502025018975 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 502025018976 Prephenate dehydratase; Region: PDT; pfam00800 502025018977 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 502025018978 putative L-Phe binding site [chemical binding]; other site 502025018979 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 502025018980 Prostaglandin dehydrogenases; Region: PGDH; cd05288 502025018981 NAD(P) binding site [chemical binding]; other site 502025018982 substrate binding site [chemical binding]; other site 502025018983 dimer interface [polypeptide binding]; other site 502025018984 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 502025018985 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 502025018986 C-terminal domain interface [polypeptide binding]; other site 502025018987 GSH binding site (G-site) [chemical binding]; other site 502025018988 dimer interface [polypeptide binding]; other site 502025018989 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 502025018990 N-terminal domain interface [polypeptide binding]; other site 502025018991 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 502025018992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 502025018993 POT family; Region: PTR2; cl17359 502025018994 FOG: CBS domain [General function prediction only]; Region: COG0517 502025018995 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 502025018996 C factor cell-cell signaling protein; Provisional; Region: PRK09009 502025018997 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 502025018998 NADP binding site [chemical binding]; other site 502025018999 homodimer interface [polypeptide binding]; other site 502025019000 active site 502025019001 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 502025019002 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 502025019003 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 502025019004 putative trimer interface [polypeptide binding]; other site 502025019005 putative active site [active] 502025019006 putative substrate binding site [chemical binding]; other site 502025019007 putative CoA binding site [chemical binding]; other site 502025019008 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 502025019009 DNA methylase; Region: N6_N4_Mtase; pfam01555 502025019010 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 502025019011 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 502025019012 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 502025019013 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 502025019014 GrpE; Region: GrpE; pfam01025 502025019015 dimer interface [polypeptide binding]; other site 502025019016 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 502025019017 Uncharacterized conserved protein [Function unknown]; Region: COG2947 502025019018 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 502025019019 active site 502025019020 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 502025019021 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 502025019022 catalytic residues [active] 502025019023 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 502025019024 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 502025019025 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 502025019026 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 502025019027 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 502025019028 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 502025019029 active site 502025019030 Zn binding site [ion binding]; other site 502025019031 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 502025019032 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 502025019033 G1 box; other site 502025019034 GTP/Mg2+ binding site [chemical binding]; other site 502025019035 G2 box; other site 502025019036 Switch I region; other site 502025019037 G3 box; other site 502025019038 Switch II region; other site 502025019039 G4 box; other site 502025019040 G5 box; other site 502025019041 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 502025019042 recombination protein RecR; Reviewed; Region: recR; PRK00076 502025019043 RecR protein; Region: RecR; pfam02132 502025019044 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 502025019045 putative active site [active] 502025019046 putative metal-binding site [ion binding]; other site 502025019047 tetramer interface [polypeptide binding]; other site 502025019048 hypothetical protein; Validated; Region: PRK00153 502025019049 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 502025019050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 502025019051 Walker A motif; other site 502025019052 ATP binding site [chemical binding]; other site 502025019053 Walker B motif; other site 502025019054 arginine finger; other site 502025019055 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 502025019056 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 502025019057 nucleoside/Zn binding site; other site 502025019058 dimer interface [polypeptide binding]; other site 502025019059 catalytic motif [active] 502025019060 Tetratricopeptide repeat; Region: TPR_16; pfam13432 502025019061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025019062 TPR motif; other site 502025019063 binding surface 502025019064 TPR repeat; Region: TPR_11; pfam13414 502025019065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025019066 binding surface 502025019067 TPR motif; other site 502025019068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025019069 TPR motif; other site 502025019070 binding surface 502025019071 TPR repeat; Region: TPR_11; pfam13414 502025019072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025019073 binding surface 502025019074 TPR motif; other site 502025019075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025019076 TPR motif; other site 502025019077 TPR repeat; Region: TPR_11; pfam13414 502025019078 binding surface 502025019079 TPR repeat; Region: TPR_11; pfam13414 502025019080 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 502025019081 catalytic center binding site [active] 502025019082 ATP binding site [chemical binding]; other site 502025019083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 502025019084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 502025019085 phosphopeptide binding site; other site 502025019086 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 502025019087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025019088 active site 502025019089 phosphorylation site [posttranslational modification] 502025019090 intermolecular recognition site; other site 502025019091 dimerization interface [polypeptide binding]; other site 502025019092 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 502025019093 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 502025019094 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 502025019095 Dynamin family; Region: Dynamin_N; pfam00350 502025019096 G1 box; other site 502025019097 GTP/Mg2+ binding site [chemical binding]; other site 502025019098 G2 box; other site 502025019099 Switch I region; other site 502025019100 G3 box; other site 502025019101 Switch II region; other site 502025019102 G4 box; other site 502025019103 G5 box; other site 502025019104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 502025019105 binding surface 502025019106 TPR motif; other site 502025019107 TPR repeat; Region: TPR_11; pfam13414 502025019108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 502025019109 TPR repeat; Region: TPR_11; pfam13414 502025019110 TPR motif; other site 502025019111 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 502025019112 Dynamin family; Region: Dynamin_N; pfam00350 502025019113 G1 box; other site 502025019114 GTP/Mg2+ binding site [chemical binding]; other site 502025019115 G2 box; other site 502025019116 Switch I region; other site 502025019117 G3 box; other site 502025019118 Switch II region; other site 502025019119 G4 box; other site 502025019120 G5 box; other site 502025019121 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 502025019122 RNA/DNA hybrid binding site [nucleotide binding]; other site 502025019123 active site 502025019124 RNA polymerase sigma factor; Provisional; Region: PRK12513 502025019125 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 502025019126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 502025019127 DNA binding residues [nucleotide binding] 502025019128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 502025019129 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 502025019130 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 502025019131 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 502025019132 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 502025019133 DNA binding site [nucleotide binding] 502025019134 catalytic residue [active] 502025019135 H2TH interface [polypeptide binding]; other site 502025019136 putative catalytic residues [active] 502025019137 turnover-facilitating residue; other site 502025019138 intercalation triad [nucleotide binding]; other site 502025019139 8OG recognition residue [nucleotide binding]; other site 502025019140 putative reading head residues; other site 502025019141 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 502025019142 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 502025019143 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 502025019144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 502025019145 S-adenosylmethionine binding site [chemical binding]; other site 502025019146 UGMP family protein; Validated; Region: PRK09604 502025019147 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 502025019148 Response regulator receiver domain; Region: Response_reg; pfam00072 502025019149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 502025019150 active site 502025019151 phosphorylation site [posttranslational modification] 502025019152 intermolecular recognition site; other site 502025019153 dimerization interface [polypeptide binding]; other site 502025019154 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 502025019155 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 502025019156 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 502025019157 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 502025019158 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 502025019159 AAA domain; Region: AAA_26; pfam13500 502025019160 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 502025019161 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 502025019162 inhibitor-cofactor binding pocket; inhibition site 502025019163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 502025019164 catalytic residue [active] 502025019165 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 502025019166 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 502025019167 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 502025019168 catalytic residue [active] 502025019169 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 502025019170 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 502025019171 trmE is a tRNA modification GTPase; Region: trmE; cd04164 502025019172 G1 box; other site 502025019173 GTP/Mg2+ binding site [chemical binding]; other site 502025019174 Switch I region; other site 502025019175 G2 box; other site 502025019176 Switch II region; other site 502025019177 G3 box; other site 502025019178 G4 box; other site 502025019179 G5 box; other site 502025019180 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 502025019181 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 502025019182 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 502025019183 G-X-X-G motif; other site 502025019184 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 502025019185 RxxxH motif; other site 502025019186 membrane protein insertase; Provisional; Region: PRK01318 502025019187 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 502025019188 Haemolytic domain; Region: Haemolytic; pfam01809