-- dump date 20140619_110445 -- class Genbank::misc_feature -- table misc_feature_note -- id note 760192000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 760192000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 760192000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192000004 Walker A motif; other site 760192000005 ATP binding site [chemical binding]; other site 760192000006 Walker B motif; other site 760192000007 arginine finger; other site 760192000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 760192000009 DnaA box-binding interface [nucleotide binding]; other site 760192000010 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 760192000011 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192000012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192000013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192000014 DNA binding residues [nucleotide binding] 760192000015 CotH protein; Region: CotH; pfam08757 760192000016 Family description; Region: DsbD_2; pfam13386 760192000017 FixH; Region: FixH; pfam05751 760192000018 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 760192000019 4Fe-4S binding domain; Region: Fer4_5; pfam12801 760192000020 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 760192000021 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 760192000022 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192000023 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 760192000024 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 760192000025 Low-spin heme binding site [chemical binding]; other site 760192000026 Putative water exit pathway; other site 760192000027 Binuclear center (active site) [active] 760192000028 Putative proton exit pathway; other site 760192000029 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 760192000030 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 760192000031 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 760192000032 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 760192000033 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192000034 putative active site [active] 760192000035 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 760192000036 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 760192000037 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 760192000038 BCCT family transporter; Region: BCCT; pfam02028 760192000039 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 760192000040 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 760192000041 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192000042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192000043 active site 760192000044 phosphorylation site [posttranslational modification] 760192000045 intermolecular recognition site; other site 760192000046 dimerization interface [polypeptide binding]; other site 760192000047 LytTr DNA-binding domain; Region: LytTR; smart00850 760192000048 Histidine kinase; Region: His_kinase; pfam06580 760192000049 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 760192000050 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192000051 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 760192000052 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 760192000053 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 760192000054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192000055 putative substrate translocation pore; other site 760192000056 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192000057 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192000058 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192000059 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 760192000060 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 760192000061 DinB superfamily; Region: DinB_2; pfam12867 760192000062 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 760192000063 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 760192000064 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 760192000065 active site 760192000066 substrate binding site [chemical binding]; other site 760192000067 Mg2+ binding site [ion binding]; other site 760192000068 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 760192000069 active site 760192000070 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 760192000071 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 760192000072 active site 760192000073 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 760192000074 catalytic triad [active] 760192000075 dimer interface [polypeptide binding]; other site 760192000076 beta-propeller repeat; Region: PQQ; smart00564 760192000077 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 760192000078 proline aminopeptidase P II; Provisional; Region: PRK10879 760192000079 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 760192000080 active site 760192000081 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760192000082 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 760192000083 Amidase; Region: Amidase; pfam01425 760192000084 4-alpha-glucanotransferase; Region: PLN02950 760192000085 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 760192000086 starch-binding site 2 [chemical binding]; other site 760192000087 starch-binding site 1 [chemical binding]; other site 760192000088 Starch binding domain; Region: CBM_2; smart01065 760192000089 starch-binding site 2 [chemical binding]; other site 760192000090 starch-binding site 1 [chemical binding]; other site 760192000091 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 760192000092 putative acetyltransferase; Provisional; Region: PRK03624 760192000093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192000094 Coenzyme A binding pocket [chemical binding]; other site 760192000095 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760192000096 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760192000097 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192000098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192000099 active site 760192000100 phosphorylation site [posttranslational modification] 760192000101 intermolecular recognition site; other site 760192000102 dimerization interface [polypeptide binding]; other site 760192000103 LytTr DNA-binding domain; Region: LytTR; smart00850 760192000104 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 760192000105 active site 760192000106 dimerization interface [polypeptide binding]; other site 760192000107 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 760192000108 SnoaL-like domain; Region: SnoaL_2; pfam12680 760192000109 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 760192000110 PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases; Region: PAP2_like_1; cd03380 760192000111 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 760192000112 active site 760192000113 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192000114 active site 760192000115 Histidine kinase; Region: His_kinase; pfam06580 760192000116 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192000117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192000118 active site 760192000119 phosphorylation site [posttranslational modification] 760192000120 intermolecular recognition site; other site 760192000121 dimerization interface [polypeptide binding]; other site 760192000122 LytTr DNA-binding domain; Region: LytTR; smart00850 760192000123 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 760192000124 putative carbohydrate kinase; Provisional; Region: PRK10565 760192000125 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 760192000126 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 760192000127 putative substrate binding site [chemical binding]; other site 760192000128 putative ATP binding site [chemical binding]; other site 760192000129 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 760192000130 Peptidase family M48; Region: Peptidase_M48; pfam01435 760192000131 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 760192000132 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 760192000133 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 760192000134 Phosphoesterase family; Region: Phosphoesterase; pfam04185 760192000135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192000136 TPR repeat; Region: TPR_11; pfam13414 760192000137 TPR motif; other site 760192000138 binding surface 760192000139 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 760192000140 Peptidase family M50; Region: Peptidase_M50; pfam02163 760192000141 active site 760192000142 putative substrate binding region [chemical binding]; other site 760192000143 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 760192000144 FOG: CBS domain [General function prediction only]; Region: COG0517 760192000145 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 760192000146 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 760192000147 alpha subunit interface [polypeptide binding]; other site 760192000148 TPP binding site [chemical binding]; other site 760192000149 heterodimer interface [polypeptide binding]; other site 760192000150 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 760192000151 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 760192000152 HNH endonuclease; Region: HNH_3; pfam13392 760192000153 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 760192000154 DNA binding site [nucleotide binding] 760192000155 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 760192000156 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 760192000157 catalytic motif [active] 760192000158 Zn binding site [ion binding]; other site 760192000159 RibD C-terminal domain; Region: RibD_C; cl17279 760192000160 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 760192000161 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 760192000162 6-phosphofructokinase; Provisional; Region: PRK03202 760192000163 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 760192000164 active site 760192000165 ADP/pyrophosphate binding site [chemical binding]; other site 760192000166 dimerization interface [polypeptide binding]; other site 760192000167 allosteric effector site; other site 760192000168 fructose-1,6-bisphosphate binding site; other site 760192000169 Histidine kinase; Region: His_kinase; pfam06580 760192000170 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192000171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192000172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192000173 DNA binding residues [nucleotide binding] 760192000174 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 760192000175 Leucine rich repeat; Region: LRR_8; pfam13855 760192000176 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 760192000177 Substrate binding site [chemical binding]; other site 760192000178 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192000179 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192000180 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192000181 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 760192000182 G1 box; other site 760192000183 GTP/Mg2+ binding site [chemical binding]; other site 760192000184 G2 box; other site 760192000185 Switch I region; other site 760192000186 G3 box; other site 760192000187 Switch II region; other site 760192000188 G4 box; other site 760192000189 G5 box; other site 760192000190 TIR domain; Region: TIR_2; pfam13676 760192000191 Carboxylesterase family; Region: COesterase; pfam00135 760192000192 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192000193 substrate binding pocket [chemical binding]; other site 760192000194 catalytic triad [active] 760192000195 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192000196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192000197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192000198 DNA binding residues [nucleotide binding] 760192000199 diaminopimelate decarboxylase; Region: lysA; TIGR01048 760192000200 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 760192000201 active site 760192000202 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760192000203 substrate binding site [chemical binding]; other site 760192000204 catalytic residues [active] 760192000205 dimer interface [polypeptide binding]; other site 760192000206 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 760192000207 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760192000208 active site 760192000209 HIGH motif; other site 760192000210 nucleotide binding site [chemical binding]; other site 760192000211 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 760192000212 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 760192000213 active site 760192000214 KMSKS motif; other site 760192000215 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 760192000216 tRNA binding surface [nucleotide binding]; other site 760192000217 anticodon binding site; other site 760192000218 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 760192000219 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 760192000220 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 760192000221 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192000222 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 760192000223 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 760192000224 active site 760192000225 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 760192000226 nudix motif; other site 760192000227 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 760192000228 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760192000229 catalytic core [active] 760192000230 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 760192000231 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192000232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192000233 active site 760192000234 phosphorylation site [posttranslational modification] 760192000235 intermolecular recognition site; other site 760192000236 dimerization interface [polypeptide binding]; other site 760192000237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192000238 DNA binding site [nucleotide binding] 760192000239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192000240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192000241 dimer interface [polypeptide binding]; other site 760192000242 phosphorylation site [posttranslational modification] 760192000243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192000244 ATP binding site [chemical binding]; other site 760192000245 Mg2+ binding site [ion binding]; other site 760192000246 G-X-G motif; other site 760192000247 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 760192000248 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760192000249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192000250 Walker A/P-loop; other site 760192000251 ATP binding site [chemical binding]; other site 760192000252 Q-loop/lid; other site 760192000253 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760192000254 ABC transporter signature motif; other site 760192000255 Walker B; other site 760192000256 D-loop; other site 760192000257 ABC transporter; Region: ABC_tran_2; pfam12848 760192000258 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760192000259 Methane oxygenase PmoA; Region: PmoA; pfam14100 760192000260 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192000261 HEAT repeats; Region: HEAT_2; pfam13646 760192000262 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 760192000263 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192000264 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192000265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192000266 TPR motif; other site 760192000267 binding surface 760192000268 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192000269 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192000270 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 760192000271 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 760192000272 active site 760192000273 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 760192000274 Phosphotransferase enzyme family; Region: APH; pfam01636 760192000275 putative active site [active] 760192000276 putative substrate binding site [chemical binding]; other site 760192000277 ATP binding site [chemical binding]; other site 760192000278 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192000279 putative active site [active] 760192000280 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 760192000281 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 760192000282 NAD(P) binding site [chemical binding]; other site 760192000283 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 760192000284 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 760192000285 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 760192000286 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 760192000287 active site 760192000288 metal binding site [ion binding]; metal-binding site 760192000289 homotetramer interface [polypeptide binding]; other site 760192000290 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 760192000291 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 760192000292 putative RNA binding site [nucleotide binding]; other site 760192000293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192000294 S-adenosylmethionine binding site [chemical binding]; other site 760192000295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 760192000296 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 760192000297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192000298 Walker A motif; other site 760192000299 ATP binding site [chemical binding]; other site 760192000300 Walker B motif; other site 760192000301 arginine finger; other site 760192000302 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 760192000303 Protein of unknown function (DUF819); Region: DUF819; cl02317 760192000304 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 760192000305 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 760192000306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192000307 S-adenosylmethionine binding site [chemical binding]; other site 760192000308 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 760192000309 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 760192000310 dimer interface [polypeptide binding]; other site 760192000311 active site 760192000312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760192000313 substrate binding site [chemical binding]; other site 760192000314 catalytic residue [active] 760192000315 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 760192000316 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 760192000317 nudix motif; other site 760192000318 acetylornithine aminotransferase; Provisional; Region: PRK04260 760192000319 methionine sulfoxide reductase B; Provisional; Region: PRK00222 760192000320 methionine sulfoxide reductase B; Provisional; Region: PRK05508 760192000321 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 760192000322 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 760192000323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192000324 FeS/SAM binding site; other site 760192000325 gliding motility-associated protein GldC; Region: GldC; TIGR03515 760192000326 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192000327 Putative esterase; Region: Esterase; pfam00756 760192000328 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 760192000329 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 760192000330 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 760192000331 active site 760192000332 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192000333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192000334 active site 760192000335 phosphorylation site [posttranslational modification] 760192000336 intermolecular recognition site; other site 760192000337 dimerization interface [polypeptide binding]; other site 760192000338 LytTr DNA-binding domain; Region: LytTR; smart00850 760192000339 Histidine kinase; Region: His_kinase; pfam06580 760192000340 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 760192000341 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 760192000342 putative acyl-acceptor binding pocket; other site 760192000343 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 760192000344 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192000345 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 760192000346 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 760192000347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192000348 Walker A/P-loop; other site 760192000349 ATP binding site [chemical binding]; other site 760192000350 Q-loop/lid; other site 760192000351 ABC transporter signature motif; other site 760192000352 Walker B; other site 760192000353 D-loop; other site 760192000354 H-loop/switch region; other site 760192000355 CcmE; Region: CcmE; cl00994 760192000356 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 760192000357 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 760192000358 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 760192000359 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 760192000360 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192000361 putative active site [active] 760192000362 putative NTP binding site [chemical binding]; other site 760192000363 putative nucleic acid binding site [nucleotide binding]; other site 760192000364 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 760192000365 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 760192000366 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192000367 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 760192000368 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 760192000369 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 760192000370 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 760192000371 conserved cys residue [active] 760192000372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192000373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192000374 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 760192000375 dimer interface [polypeptide binding]; other site 760192000376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192000377 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 760192000378 putative active cleft [active] 760192000379 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 760192000380 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 760192000381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192000382 FeS/SAM binding site; other site 760192000383 TRAM domain; Region: TRAM; pfam01938 760192000384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192000385 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192000386 Walker A motif; other site 760192000387 ATP binding site [chemical binding]; other site 760192000388 Walker B motif; other site 760192000389 arginine finger; other site 760192000390 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760192000391 Lipopolysaccharide-assembly; Region: LptE; pfam04390 760192000392 Divergent AAA domain; Region: AAA_4; pfam04326 760192000393 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 760192000394 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 760192000395 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760192000396 P-loop; other site 760192000397 Magnesium ion binding site [ion binding]; other site 760192000398 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760192000399 Magnesium ion binding site [ion binding]; other site 760192000400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192000401 Coenzyme A binding pocket [chemical binding]; other site 760192000402 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192000403 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 760192000404 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192000405 inhibitor-cofactor binding pocket; inhibition site 760192000406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192000407 catalytic residue [active] 760192000408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192000409 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 760192000410 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 760192000411 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 760192000412 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 760192000413 putative ligand binding site [chemical binding]; other site 760192000414 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 760192000415 DEAD-like helicases superfamily; Region: DEXDc; smart00487 760192000416 ATP binding site [chemical binding]; other site 760192000417 Mg++ binding site [ion binding]; other site 760192000418 motif III; other site 760192000419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192000420 nucleotide binding region [chemical binding]; other site 760192000421 ATP-binding site [chemical binding]; other site 760192000422 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 760192000423 cytidylate kinase; Provisional; Region: cmk; PRK00023 760192000424 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 760192000425 CMP-binding site; other site 760192000426 The sites determining sugar specificity; other site 760192000427 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 760192000428 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 760192000429 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 760192000430 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192000431 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192000432 FtsX-like permease family; Region: FtsX; pfam02687 760192000433 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 760192000434 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 760192000435 ATP binding site [chemical binding]; other site 760192000436 Mg++ binding site [ion binding]; other site 760192000437 motif III; other site 760192000438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192000439 nucleotide binding region [chemical binding]; other site 760192000440 ATP-binding site [chemical binding]; other site 760192000441 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 760192000442 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 760192000443 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 760192000444 active site 760192000445 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 760192000446 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 760192000447 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 760192000448 FAD binding domain; Region: FAD_binding_4; pfam01565 760192000449 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 760192000450 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 760192000451 active site residue [active] 760192000452 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 760192000453 active site residue [active] 760192000454 hypothetical protein; Provisional; Region: PRK06148 760192000455 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 760192000456 active site 760192000457 ATP binding site [chemical binding]; other site 760192000458 Peptidase family M23; Region: Peptidase_M23; pfam01551 760192000459 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192000460 inhibitor-cofactor binding pocket; inhibition site 760192000461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192000462 catalytic residue [active] 760192000463 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 760192000464 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 760192000465 active site 760192000466 catalytic site [active] 760192000467 substrate binding site [chemical binding]; other site 760192000468 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 760192000469 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 760192000470 putative active site [active] 760192000471 putative metal binding site [ion binding]; other site 760192000472 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760192000473 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760192000474 PQQ-like domain; Region: PQQ_2; pfam13360 760192000475 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192000476 universal stress protein UspE; Provisional; Region: PRK11175 760192000477 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192000478 Ligand Binding Site [chemical binding]; other site 760192000479 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192000480 Ligand Binding Site [chemical binding]; other site 760192000481 short chain dehydrogenase; Provisional; Region: PRK06179 760192000482 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 760192000483 NADP binding site [chemical binding]; other site 760192000484 active site 760192000485 steroid binding site; other site 760192000486 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 760192000487 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 760192000488 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 760192000489 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 760192000490 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 760192000491 metal-binding site [ion binding] 760192000492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760192000493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192000494 motif I; other site 760192000495 motif II; other site 760192000496 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 760192000497 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 760192000498 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 760192000499 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 760192000500 FOG: CBS domain [General function prediction only]; Region: COG0517 760192000501 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 760192000502 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 760192000503 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 760192000504 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 760192000505 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 760192000506 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 760192000507 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 760192000508 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192000509 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192000510 protein binding site [polypeptide binding]; other site 760192000511 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192000512 protein binding site [polypeptide binding]; other site 760192000513 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 760192000514 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 760192000515 GMP synthase; Reviewed; Region: guaA; PRK00074 760192000516 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 760192000517 AMP/PPi binding site [chemical binding]; other site 760192000518 candidate oxyanion hole; other site 760192000519 catalytic triad [active] 760192000520 potential glutamine specificity residues [chemical binding]; other site 760192000521 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 760192000522 ATP Binding subdomain [chemical binding]; other site 760192000523 Ligand Binding sites [chemical binding]; other site 760192000524 Dimerization subdomain; other site 760192000525 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 760192000526 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 760192000527 ligand binding site [chemical binding]; other site 760192000528 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 760192000529 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 760192000530 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192000531 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192000532 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192000533 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 760192000534 Cytochrome c; Region: Cytochrom_C; pfam00034 760192000535 Protein of unknown function, DUF399; Region: DUF399; pfam04187 760192000536 hypothetical protein; Provisional; Region: PRK09256 760192000537 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 760192000538 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 760192000539 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 760192000540 aspartate aminotransferase; Provisional; Region: PRK05764 760192000541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760192000542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192000543 homodimer interface [polypeptide binding]; other site 760192000544 catalytic residue [active] 760192000545 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 760192000546 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192000547 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192000548 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760192000549 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192000550 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192000551 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192000552 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 760192000553 Bacterial Ig-like domain; Region: Big_5; pfam13205 760192000554 Bacterial Ig-like domain; Region: Big_5; pfam13205 760192000555 MG2 domain; Region: A2M_N; pfam01835 760192000556 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 760192000557 Alpha-2-macroglobulin family; Region: A2M; pfam00207 760192000558 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 760192000559 surface patch; other site 760192000560 thioester region; other site 760192000561 specificity defining residues; other site 760192000562 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192000563 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 760192000564 Cytochrome c; Region: Cytochrom_C; pfam00034 760192000565 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192000566 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 760192000567 Metal-binding active site; metal-binding site 760192000568 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 760192000569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192000570 NAD(P) binding site [chemical binding]; other site 760192000571 active site 760192000572 Transposase; Region: DEDD_Tnp_IS110; pfam01548 760192000573 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 760192000574 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 760192000575 fructuronate transporter; Provisional; Region: PRK10034; cl15264 760192000576 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 760192000577 putative catalytic site [active] 760192000578 putative metal binding site [ion binding]; other site 760192000579 putative phosphate binding site [ion binding]; other site 760192000580 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192000581 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192000582 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 760192000583 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 760192000584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192000585 catalytic residue [active] 760192000586 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 760192000587 active site 760192000588 catalytic residues [active] 760192000589 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 760192000590 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 760192000591 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 760192000592 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 760192000593 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 760192000594 Peptidase family M1; Region: Peptidase_M1; pfam01433 760192000595 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 760192000596 Zn binding site [ion binding]; other site 760192000597 VPS10 domain; Region: VPS10; smart00602 760192000598 VPS10 domain; Region: VPS10; smart00602 760192000599 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 760192000600 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192000601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192000602 active site 760192000603 phosphorylation site [posttranslational modification] 760192000604 intermolecular recognition site; other site 760192000605 dimerization interface [polypeptide binding]; other site 760192000606 LytTr DNA-binding domain; Region: LytTR; smart00850 760192000607 Histidine kinase; Region: His_kinase; pfam06580 760192000608 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 760192000609 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192000610 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192000611 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192000612 structural tetrad; other site 760192000613 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192000614 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192000615 structural tetrad; other site 760192000616 Caspase domain; Region: Peptidase_C14; pfam00656 760192000617 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 760192000618 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 760192000619 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 760192000620 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 760192000621 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 760192000622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 760192000623 Uncharacterized conserved protein [Function unknown]; Region: COG2308 760192000624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 760192000625 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 760192000626 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 760192000627 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 760192000628 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 760192000629 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 760192000630 active site 760192000631 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 760192000632 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 760192000633 Potassium binding sites [ion binding]; other site 760192000634 Cesium cation binding sites [ion binding]; other site 760192000635 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 760192000636 active site 760192000637 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 760192000638 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 760192000639 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760192000640 active site 760192000641 nucleotide binding site [chemical binding]; other site 760192000642 HIGH motif; other site 760192000643 KMSKS motif; other site 760192000644 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 760192000645 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 760192000646 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 760192000647 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 760192000648 active site 760192000649 catalytic site [active] 760192000650 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192000651 Caspase domain; Region: Peptidase_C14; pfam00656 760192000652 Protein of unknown function (DUF968); Region: DUF968; pfam06147 760192000653 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 760192000654 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 760192000655 putative active site; other site 760192000656 catalytic triad [active] 760192000657 putative dimer interface [polypeptide binding]; other site 760192000658 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 760192000659 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 760192000660 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 760192000661 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 760192000662 trehalose synthase; Region: treS_nterm; TIGR02456 760192000663 active site 760192000664 catalytic site [active] 760192000665 starch-binding site 2 [chemical binding]; other site 760192000666 Starch binding domain; Region: CBM_2; smart01065 760192000667 starch-binding site 1 [chemical binding]; other site 760192000668 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192000669 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192000670 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192000671 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 760192000672 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192000673 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192000674 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192000675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192000676 Radical SAM superfamily; Region: Radical_SAM; pfam04055 760192000677 FeS/SAM binding site; other site 760192000678 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 760192000679 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192000680 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192000681 catalytic residues [active] 760192000682 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 760192000683 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192000684 catalytic loop [active] 760192000685 iron binding site [ion binding]; other site 760192000686 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 760192000687 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 760192000688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192000689 active site 760192000690 motif I; other site 760192000691 motif II; other site 760192000692 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 760192000693 UbiA prenyltransferase family; Region: UbiA; pfam01040 760192000694 Maf-like protein; Region: Maf; pfam02545 760192000695 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 760192000696 active site 760192000697 dimer interface [polypeptide binding]; other site 760192000698 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 760192000699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192000700 ATP binding site [chemical binding]; other site 760192000701 putative Mg++ binding site [ion binding]; other site 760192000702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192000703 nucleotide binding region [chemical binding]; other site 760192000704 ATP-binding site [chemical binding]; other site 760192000705 HemN C-terminal domain; Region: HemN_C; pfam06969 760192000706 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 760192000707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192000708 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 760192000709 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 760192000710 substrate binding [chemical binding]; other site 760192000711 active site 760192000712 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 760192000713 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 760192000714 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 760192000715 RNA methyltransferase, RsmE family; Region: TIGR00046 760192000716 RIP metalloprotease RseP; Region: TIGR00054 760192000717 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 760192000718 active site 760192000719 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 760192000720 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 760192000721 protein binding site [polypeptide binding]; other site 760192000722 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 760192000723 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 760192000724 putative substrate binding region [chemical binding]; other site 760192000725 putative substrate binding region [chemical binding]; other site 760192000726 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 760192000727 Fe-S protein assembly co-chaperone HscB; Region: hscB; TIGR00714 760192000728 HSP70 interaction site [polypeptide binding]; other site 760192000729 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 760192000730 Peptidase S46; Region: Peptidase_S46; pfam10459 760192000731 Peptidase S46; Region: Peptidase_S46; pfam10459 760192000732 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 760192000733 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 760192000734 putative acyl-acceptor binding pocket; other site 760192000735 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 760192000736 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 760192000737 translation initiation factor Sui1; Validated; Region: PRK06824 760192000738 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 760192000739 putative rRNA binding site [nucleotide binding]; other site 760192000740 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 760192000741 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760192000742 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192000743 catalytic residues [active] 760192000744 Protein of unknown function DUF58; Region: DUF58; pfam01882 760192000745 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 760192000746 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760192000747 RNA binding surface [nucleotide binding]; other site 760192000748 SnoaL-like domain; Region: SnoaL_2; pfam12680 760192000749 selenophosphate synthetase; Provisional; Region: PRK00943 760192000750 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 760192000751 dimerization interface [polypeptide binding]; other site 760192000752 putative ATP binding site [chemical binding]; other site 760192000753 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 760192000754 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 760192000755 active site residue [active] 760192000756 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 760192000757 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 760192000758 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 760192000759 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 760192000760 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 760192000761 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 760192000762 GIY-YIG motif/motif A; other site 760192000763 putative active site [active] 760192000764 putative metal binding site [ion binding]; other site 760192000765 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 760192000766 active site 760192000767 intersubunit interactions; other site 760192000768 catalytic residue [active] 760192000769 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 760192000770 DNA polymerase III, delta subunit; Region: holA; TIGR01128 760192000771 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192000772 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 760192000773 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 760192000774 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 760192000775 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 760192000776 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192000777 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192000778 futalosine nucleosidase; Region: fut_nucase; TIGR03664 760192000779 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192000780 Caspase domain; Region: Peptidase_C14; pfam00656 760192000781 Putative serine esterase (DUF676); Region: DUF676; pfam05057 760192000782 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 760192000783 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192000784 putative active site [active] 760192000785 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 760192000786 mce related protein; Region: MCE; pfam02470 760192000787 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 760192000788 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 760192000789 active site 760192000790 metal binding site [ion binding]; metal-binding site 760192000791 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 760192000792 GLPGLI family protein; Region: GLPGLI; TIGR01200 760192000793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192000794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192000795 dimer interface [polypeptide binding]; other site 760192000796 phosphorylation site [posttranslational modification] 760192000797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192000798 ATP binding site [chemical binding]; other site 760192000799 Mg2+ binding site [ion binding]; other site 760192000800 G-X-G motif; other site 760192000801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192000802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192000803 active site 760192000804 phosphorylation site [posttranslational modification] 760192000805 intermolecular recognition site; other site 760192000806 dimerization interface [polypeptide binding]; other site 760192000807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192000808 DNA binding site [nucleotide binding] 760192000809 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 760192000810 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192000811 dockerin binding interface; other site 760192000812 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192000813 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 760192000814 NADH dehydrogenase subunit B; Provisional; Region: PRK14820 760192000815 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 760192000816 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 760192000817 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 760192000818 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 760192000819 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 760192000820 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 760192000821 putative dimer interface [polypeptide binding]; other site 760192000822 [2Fe-2S] cluster binding site [ion binding]; other site 760192000823 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 760192000824 SLBB domain; Region: SLBB; pfam10531 760192000825 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 760192000826 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192000827 catalytic loop [active] 760192000828 iron binding site [ion binding]; other site 760192000829 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 760192000830 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 760192000831 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 760192000832 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 760192000833 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 760192000834 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 760192000835 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 760192000836 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 760192000837 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 760192000838 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 760192000839 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 760192000840 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 760192000841 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 760192000842 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 760192000843 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 760192000844 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 760192000845 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 760192000846 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 760192000847 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 760192000848 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192000849 PBP superfamily domain; Region: PBP_like_2; pfam12849 760192000850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192000851 binding surface 760192000852 TPR motif; other site 760192000853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192000854 TPR motif; other site 760192000855 binding surface 760192000856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192000857 binding surface 760192000858 TPR repeat; Region: TPR_11; pfam13414 760192000859 TPR motif; other site 760192000860 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 760192000861 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 760192000862 TPP-binding site [chemical binding]; other site 760192000863 dimer interface [polypeptide binding]; other site 760192000864 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 760192000865 PYR/PP interface [polypeptide binding]; other site 760192000866 dimer interface [polypeptide binding]; other site 760192000867 TPP binding site [chemical binding]; other site 760192000868 Family description; Region: VCBS; pfam13517 760192000869 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 760192000870 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 760192000871 Family description; Region: VCBS; pfam13517 760192000872 Family description; Region: VCBS; pfam13517 760192000873 Family description; Region: VCBS; pfam13517 760192000874 Family description; Region: VCBS; pfam13517 760192000875 Family description; Region: VCBS; pfam13517 760192000876 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 760192000877 Family description; Region: VCBS; pfam13517 760192000878 Family description; Region: VCBS; pfam13517 760192000879 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192000880 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192000881 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192000882 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192000883 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192000884 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192000885 SusD family; Region: SusD; pfam07980 760192000886 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 760192000887 DNA photolyase; Region: DNA_photolyase; pfam00875 760192000888 peptide chain release factor 2; Validated; Region: prfB; PRK00578 760192000889 This domain is found in peptide chain release factors; Region: PCRF; smart00937 760192000890 RF-1 domain; Region: RF-1; pfam00472 760192000891 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 760192000892 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760192000893 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 760192000894 DHH family; Region: DHH; pfam01368 760192000895 DHHA1 domain; Region: DHHA1; pfam02272 760192000896 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 760192000897 active site 760192000898 multimer interface [polypeptide binding]; other site 760192000899 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 760192000900 MutS domain III; Region: MutS_III; pfam05192 760192000901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192000902 Walker A/P-loop; other site 760192000903 ATP binding site [chemical binding]; other site 760192000904 Q-loop/lid; other site 760192000905 ABC transporter signature motif; other site 760192000906 Walker B; other site 760192000907 D-loop; other site 760192000908 H-loop/switch region; other site 760192000909 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 760192000910 Smr domain; Region: Smr; pfam01713 760192000911 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 760192000912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192000913 ribulokinase; Provisional; Region: PRK04123 760192000914 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 760192000915 N- and C-terminal domain interface [polypeptide binding]; other site 760192000916 active site 760192000917 MgATP binding site [chemical binding]; other site 760192000918 catalytic site [active] 760192000919 metal binding site [ion binding]; metal-binding site 760192000920 carbohydrate binding site [chemical binding]; other site 760192000921 homodimer interface [polypeptide binding]; other site 760192000922 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 760192000923 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 760192000924 intersubunit interface [polypeptide binding]; other site 760192000925 active site 760192000926 Zn2+ binding site [ion binding]; other site 760192000927 L-arabinose isomerase; Provisional; Region: PRK02929 760192000928 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 760192000929 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 760192000930 trimer interface [polypeptide binding]; other site 760192000931 putative substrate binding site [chemical binding]; other site 760192000932 putative metal binding site [ion binding]; other site 760192000933 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 760192000934 putative transporter; Provisional; Region: PRK10484 760192000935 Na binding site [ion binding]; other site 760192000936 substrate binding site [chemical binding]; other site 760192000937 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 760192000938 nudix motif; other site 760192000939 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 760192000940 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 760192000941 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 760192000942 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 760192000943 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 760192000944 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 760192000945 Ligand binding site [chemical binding]; other site 760192000946 Electron transfer flavoprotein domain; Region: ETF; pfam01012 760192000947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192000948 binding surface 760192000949 TPR motif; other site 760192000950 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 760192000951 Methyltransferase domain; Region: Methyltransf_23; pfam13489 760192000952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192000953 S-adenosylmethionine binding site [chemical binding]; other site 760192000954 Smr domain; Region: Smr; pfam01713 760192000955 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 760192000956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192000957 active site 760192000958 motif I; other site 760192000959 motif II; other site 760192000960 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 760192000961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192000962 putative substrate translocation pore; other site 760192000963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192000964 Protein of unknown function, DUF547; Region: DUF547; pfam04784 760192000965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 760192000966 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 760192000967 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 760192000968 Methyltransferase domain; Region: Methyltransf_31; pfam13847 760192000969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192000970 S-adenosylmethionine binding site [chemical binding]; other site 760192000971 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 760192000972 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192000973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192000974 S-adenosylmethionine binding site [chemical binding]; other site 760192000975 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 760192000976 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 760192000977 active site 760192000978 dimer interface [polypeptide binding]; other site 760192000979 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 760192000980 Ligand Binding Site [chemical binding]; other site 760192000981 Molecular Tunnel; other site 760192000982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192000983 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 760192000984 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192000985 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192000986 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192000987 Methyltransferase domain; Region: Methyltransf_23; pfam13489 760192000988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192000989 S-adenosylmethionine binding site [chemical binding]; other site 760192000990 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192000991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192000992 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 760192000993 putative ADP-binding pocket [chemical binding]; other site 760192000994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192000995 primosomal protein N' Region: priA; TIGR00595 760192000996 ATP binding site [chemical binding]; other site 760192000997 putative Mg++ binding site [ion binding]; other site 760192000998 helicase superfamily c-terminal domain; Region: HELICc; smart00490 760192000999 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 760192001000 DinB family; Region: DinB; cl17821 760192001001 DinB superfamily; Region: DinB_2; pfam12867 760192001002 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760192001003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192001004 Walker A/P-loop; other site 760192001005 ATP binding site [chemical binding]; other site 760192001006 Q-loop/lid; other site 760192001007 ABC transporter signature motif; other site 760192001008 Walker B; other site 760192001009 D-loop; other site 760192001010 H-loop/switch region; other site 760192001011 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 760192001012 Transcriptional regulators [Transcription]; Region: MarR; COG1846 760192001013 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 760192001014 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192001015 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192001016 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192001017 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192001018 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192001019 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192001020 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192001021 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192001022 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192001023 SusE outer membrane protein; Region: SusE; pfam14292 760192001024 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 760192001025 starch binding site [chemical binding]; other site 760192001026 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 760192001027 starch binding site [chemical binding]; other site 760192001028 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 760192001029 FOG: CBS domain [General function prediction only]; Region: COG0517 760192001030 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 760192001031 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760192001032 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 760192001033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192001034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192001035 putative substrate translocation pore; other site 760192001036 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192001037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192001038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192001039 dimer interface [polypeptide binding]; other site 760192001040 phosphorylation site [posttranslational modification] 760192001041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192001042 ATP binding site [chemical binding]; other site 760192001043 Mg2+ binding site [ion binding]; other site 760192001044 G-X-G motif; other site 760192001045 Response regulator receiver domain; Region: Response_reg; pfam00072 760192001046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192001047 active site 760192001048 phosphorylation site [posttranslational modification] 760192001049 intermolecular recognition site; other site 760192001050 dimerization interface [polypeptide binding]; other site 760192001051 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192001052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192001053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192001054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192001055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192001056 NADH(P)-binding; Region: NAD_binding_10; pfam13460 760192001057 NAD(P) binding site [chemical binding]; other site 760192001058 active site 760192001059 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760192001060 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 760192001061 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 760192001062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 760192001063 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 760192001064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192001065 active site 760192001066 motif I; other site 760192001067 motif II; other site 760192001068 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192001069 motif I; other site 760192001070 active site 760192001071 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760192001072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192001073 Coenzyme A binding pocket [chemical binding]; other site 760192001074 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192001075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192001076 binding surface 760192001077 TPR motif; other site 760192001078 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 760192001079 Transposase IS200 like; Region: Y1_Tnp; pfam01797 760192001080 cyclase homology domain; Region: CHD; cd07302 760192001081 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 760192001082 nucleotidyl binding site; other site 760192001083 metal binding site [ion binding]; metal-binding site 760192001084 dimer interface [polypeptide binding]; other site 760192001085 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 760192001086 Zn binding site [ion binding]; other site 760192001087 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 760192001088 active site 760192001089 Zn binding site [ion binding]; other site 760192001090 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 760192001091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192001092 dimerization interface [polypeptide binding]; other site 760192001093 putative DNA binding site [nucleotide binding]; other site 760192001094 putative Zn2+ binding site [ion binding]; other site 760192001095 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 760192001096 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192001097 catalytic loop [active] 760192001098 iron binding site [ion binding]; other site 760192001099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 760192001100 MOSC domain; Region: MOSC; pfam03473 760192001101 acetyl-CoA C-acetyltransferase; Region: PLN02644 760192001102 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 760192001103 dimer interface [polypeptide binding]; other site 760192001104 active site 760192001105 glycine dehydrogenase; Provisional; Region: PRK05367 760192001106 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 760192001107 tetramer interface [polypeptide binding]; other site 760192001108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192001109 catalytic residue [active] 760192001110 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 760192001111 tetramer interface [polypeptide binding]; other site 760192001112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192001113 catalytic residue [active] 760192001114 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192001115 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 760192001116 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 760192001117 NADP binding site [chemical binding]; other site 760192001118 homopentamer interface [polypeptide binding]; other site 760192001119 substrate binding site [chemical binding]; other site 760192001120 active site 760192001121 Trehalase; Region: Trehalase; cl17346 760192001122 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 760192001123 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 760192001124 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 760192001125 Sulfate transporter family; Region: Sulfate_transp; pfam00916 760192001126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192001127 HAMP domain; Region: HAMP; pfam00672 760192001128 dimerization interface [polypeptide binding]; other site 760192001129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192001130 dimer interface [polypeptide binding]; other site 760192001131 phosphorylation site [posttranslational modification] 760192001132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192001133 ATP binding site [chemical binding]; other site 760192001134 G-X-G motif; other site 760192001135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192001136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192001137 active site 760192001138 phosphorylation site [posttranslational modification] 760192001139 intermolecular recognition site; other site 760192001140 dimerization interface [polypeptide binding]; other site 760192001141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192001142 DNA binding site [nucleotide binding] 760192001143 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192001144 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 760192001145 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 760192001146 homodimer interface [polypeptide binding]; other site 760192001147 substrate-cofactor binding pocket; other site 760192001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192001149 catalytic residue [active] 760192001150 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 760192001151 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 760192001152 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192001153 Sulfatase; Region: Sulfatase; pfam00884 760192001154 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 760192001155 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 760192001156 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 760192001157 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192001158 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192001159 Histidine kinase; Region: His_kinase; pfam06580 760192001160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192001161 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192001162 active site 760192001163 phosphorylation site [posttranslational modification] 760192001164 intermolecular recognition site; other site 760192001165 dimerization interface [polypeptide binding]; other site 760192001166 LytTr DNA-binding domain; Region: LytTR; smart00850 760192001167 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 760192001168 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 760192001169 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 760192001170 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 760192001171 Malic enzyme, N-terminal domain; Region: malic; pfam00390 760192001172 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 760192001173 putative NAD(P) binding site [chemical binding]; other site 760192001174 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 760192001175 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192001176 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192001177 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192001178 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192001179 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 760192001180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192001181 pullulanase, type I; Region: pulA_typeI; TIGR02104 760192001182 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 760192001183 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 760192001184 Ca binding site [ion binding]; other site 760192001185 active site 760192001186 catalytic site [active] 760192001187 putative anti-sigmaE protein; Provisional; Region: PRK13920 760192001188 Anti-sigma-K factor rskA; Region: RskA; pfam10099 760192001189 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 760192001190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192001191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192001192 DNA binding residues [nucleotide binding] 760192001193 Predicted membrane protein [Function unknown]; Region: COG3174 760192001194 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 760192001195 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 760192001196 Alkaline phosphatase homologues; Region: alkPPc; smart00098 760192001197 active site 760192001198 dimer interface [polypeptide binding]; other site 760192001199 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 760192001200 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 760192001201 FAD binding site [chemical binding]; other site 760192001202 homotetramer interface [polypeptide binding]; other site 760192001203 substrate binding pocket [chemical binding]; other site 760192001204 catalytic base [active] 760192001205 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 760192001206 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760192001207 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 760192001208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192001209 D-galactonate transporter; Region: 2A0114; TIGR00893 760192001210 putative substrate translocation pore; other site 760192001211 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 760192001212 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 760192001213 substrate binding site [chemical binding]; other site 760192001214 oxyanion hole (OAH) forming residues; other site 760192001215 trimer interface [polypeptide binding]; other site 760192001216 feruloyl-CoA synthase; Reviewed; Region: PRK08180 760192001217 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 760192001218 acyl-activating enzyme (AAE) consensus motif; other site 760192001219 putative AMP binding site [chemical binding]; other site 760192001220 putative active site [active] 760192001221 putative CoA binding site [chemical binding]; other site 760192001222 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192001223 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 760192001224 substrate binding site [chemical binding]; other site 760192001225 zinc-binding site [ion binding]; other site 760192001226 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 760192001227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 760192001228 active site 760192001229 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 760192001230 hypothetical protein; Provisional; Region: PRK07538 760192001231 hypothetical protein; Provisional; Region: PRK07236 760192001232 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 760192001233 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192001234 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 760192001235 acetoin reductases; Region: 23BDH; TIGR02415 760192001236 NAD binding site [chemical binding]; other site 760192001237 homodimer interface [polypeptide binding]; other site 760192001238 homotetramer interface [polypeptide binding]; other site 760192001239 active site 760192001240 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 760192001241 active site 760192001242 Predicted transcriptional regulator [Transcription]; Region: COG2378 760192001243 WYL domain; Region: WYL; pfam13280 760192001244 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 760192001245 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 760192001246 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 760192001247 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 760192001248 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 760192001249 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 760192001250 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 760192001251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760192001252 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 760192001253 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 760192001254 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 760192001255 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 760192001256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 760192001257 Integrase core domain; Region: rve; pfam00665 760192001258 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 760192001259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192001260 Walker A motif; other site 760192001261 ATP binding site [chemical binding]; other site 760192001262 Walker B motif; other site 760192001263 PIN domain; Region: PIN_3; pfam13470 760192001264 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760192001265 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760192001266 DNA binding site [nucleotide binding] 760192001267 domain linker motif; other site 760192001268 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760192001269 dimerization interface [polypeptide binding]; other site 760192001270 ligand binding site [chemical binding]; other site 760192001271 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 760192001272 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 760192001273 putative NAD(P) binding site [chemical binding]; other site 760192001274 catalytic Zn binding site [ion binding]; other site 760192001275 structural Zn binding site [ion binding]; other site 760192001276 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 760192001277 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 760192001278 inhibitor binding site; inhibition site 760192001279 active site 760192001280 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 760192001281 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 760192001282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 760192001283 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 760192001284 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 760192001285 active site 760192001286 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 760192001287 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192001288 Putative esterase; Region: Esterase; pfam00756 760192001289 Trehalose utilisation; Region: ThuA; pfam06283 760192001290 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 760192001291 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 760192001292 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192001293 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192001294 Putative esterase; Region: Esterase; pfam00756 760192001295 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 760192001296 Putative esterase; Region: Esterase; pfam00756 760192001297 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192001298 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 760192001299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192001300 non-specific DNA binding site [nucleotide binding]; other site 760192001301 salt bridge; other site 760192001302 sequence-specific DNA binding site [nucleotide binding]; other site 760192001303 HipA N-terminal domain; Region: Couple_hipA; pfam13657 760192001304 HipA-like N-terminal domain; Region: HipA_N; pfam07805 760192001305 HipA-like C-terminal domain; Region: HipA_C; pfam07804 760192001306 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 760192001307 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760192001308 active site 760192001309 DNA binding site [nucleotide binding] 760192001310 Int/Topo IB signature motif; other site 760192001311 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 760192001312 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 760192001313 dimer interface [polypeptide binding]; other site 760192001314 ssDNA binding site [nucleotide binding]; other site 760192001315 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760192001316 Uncharacterized conserved protein [Function unknown]; Region: COG1479 760192001317 Protein of unknown function DUF262; Region: DUF262; pfam03235 760192001318 Uncharacterized conserved protein [Function unknown]; Region: COG3472 760192001319 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 760192001320 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 760192001321 active site clefts [active] 760192001322 zinc binding site [ion binding]; other site 760192001323 dimer interface [polypeptide binding]; other site 760192001324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 760192001325 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192001326 Sulfatase; Region: Sulfatase; pfam00884 760192001327 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192001328 Sulfatase; Region: Sulfatase; pfam00884 760192001329 AAA ATPase domain; Region: AAA_16; pfam13191 760192001330 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192001331 Predicted transcriptional regulators [Transcription]; Region: COG1733 760192001332 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 760192001333 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 760192001334 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 760192001335 catalytic residues [active] 760192001336 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 760192001337 active site pocket [active] 760192001338 oxyanion hole [active] 760192001339 catalytic triad [active] 760192001340 active site nucleophile [active] 760192001341 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192001342 dimerization interface [polypeptide binding]; other site 760192001343 putative DNA binding site [nucleotide binding]; other site 760192001344 putative Zn2+ binding site [ion binding]; other site 760192001345 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 760192001346 putative hydrophobic ligand binding site [chemical binding]; other site 760192001347 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192001348 dimerization interface [polypeptide binding]; other site 760192001349 putative DNA binding site [nucleotide binding]; other site 760192001350 putative Zn2+ binding site [ion binding]; other site 760192001351 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 760192001352 dimer interface [polypeptide binding]; other site 760192001353 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 760192001354 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192001355 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192001356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192001357 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 760192001358 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 760192001359 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192001360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192001361 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192001362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192001363 short chain dehydrogenase; Validated; Region: PRK06182 760192001364 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 760192001365 NADP binding site [chemical binding]; other site 760192001366 active site 760192001367 steroid binding site; other site 760192001368 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 760192001369 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 760192001370 Response regulator receiver domain; Region: Response_reg; pfam00072 760192001371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192001372 active site 760192001373 phosphorylation site [posttranslational modification] 760192001374 intermolecular recognition site; other site 760192001375 dimerization interface [polypeptide binding]; other site 760192001376 EthD domain; Region: EthD; cl17553 760192001377 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192001378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192001379 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 760192001380 short chain dehydrogenase; Provisional; Region: PRK06197 760192001381 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 760192001382 putative NAD(P) binding site [chemical binding]; other site 760192001383 active site 760192001384 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192001385 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192001386 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 760192001387 Peptidase family M1; Region: Peptidase_M1; pfam01433 760192001388 Zn binding site [ion binding]; other site 760192001389 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192001390 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 760192001391 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 760192001392 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 760192001393 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 760192001394 active site 760192001395 catalytic residues [active] 760192001396 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 760192001397 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 760192001398 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 760192001399 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 760192001400 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 760192001401 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 760192001402 PAAR motif; Region: PAAR_motif; pfam05488 760192001403 Phage protein D [General function prediction only]; Region: COG3500 760192001404 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 760192001405 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 760192001406 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192001407 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 760192001408 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 760192001409 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 760192001410 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 760192001411 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 760192001412 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 760192001413 transcriptional activator RfaH; Region: RfaH; TIGR01955 760192001414 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 760192001415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192001416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 760192001417 active site 760192001418 dimerization interface [polypeptide binding]; other site 760192001419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192001420 DNA binding residues [nucleotide binding] 760192001421 dimerization interface [polypeptide binding]; other site 760192001422 ethanolamine permease; Region: 2A0305; TIGR00908 760192001423 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760192001424 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192001425 catalytic residues [active] 760192001426 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 760192001427 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 760192001428 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192001429 putative active site [active] 760192001430 DinB superfamily; Region: DinB_2; pfam12867 760192001431 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 760192001432 putative ligand binding site [chemical binding]; other site 760192001433 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 760192001434 dimer interface [polypeptide binding]; other site 760192001435 putative tRNA-binding site [nucleotide binding]; other site 760192001436 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 760192001437 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 760192001438 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 760192001439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192001440 Coenzyme A binding pocket [chemical binding]; other site 760192001441 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192001442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192001443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192001444 DNA binding residues [nucleotide binding] 760192001445 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 760192001446 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 760192001447 putative dimer interface [polypeptide binding]; other site 760192001448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192001449 AAA domain; Region: AAA_21; pfam13304 760192001450 Walker A/P-loop; other site 760192001451 ATP binding site [chemical binding]; other site 760192001452 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 760192001453 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 760192001454 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 760192001455 active site 760192001456 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 760192001457 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192001458 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192001459 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 760192001460 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 760192001461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192001462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192001463 DNA binding site [nucleotide binding] 760192001464 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 760192001465 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192001466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192001467 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 760192001468 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 760192001469 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 760192001470 NAD binding site [chemical binding]; other site 760192001471 catalytic Zn binding site [ion binding]; other site 760192001472 substrate binding site [chemical binding]; other site 760192001473 structural Zn binding site [ion binding]; other site 760192001474 Putative esterase; Region: Esterase; pfam00756 760192001475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 760192001476 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 760192001477 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 760192001478 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 760192001479 putative active site [active] 760192001480 putative substrate binding site [chemical binding]; other site 760192001481 putative FMN binding site [chemical binding]; other site 760192001482 putative catalytic residues [active] 760192001483 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 760192001484 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192001485 putative active site [active] 760192001486 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 760192001487 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760192001488 Active site serine [active] 760192001489 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 760192001490 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192001491 Protein of unknown function (DUF962); Region: DUF962; cl01879 760192001492 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 760192001493 Prephenate dehydratase; Region: PDT; pfam00800 760192001494 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 760192001495 putative L-Phe binding site [chemical binding]; other site 760192001496 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 760192001497 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760192001498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192001499 homodimer interface [polypeptide binding]; other site 760192001500 catalytic residue [active] 760192001501 prephenate dehydrogenase; Validated; Region: PRK08507 760192001502 Prephenate dehydrogenase; Region: PDH; pfam02153 760192001503 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 760192001504 Chorismate mutase type II; Region: CM_2; smart00830 760192001505 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 760192001506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 760192001507 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 760192001508 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 760192001509 SPFH domain / Band 7 family; Region: Band_7; pfam01145 760192001510 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 760192001511 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 760192001512 substrate binding pocket [chemical binding]; other site 760192001513 chain length determination region; other site 760192001514 substrate-Mg2+ binding site; other site 760192001515 catalytic residues [active] 760192001516 aspartate-rich region 1; other site 760192001517 active site lid residues [active] 760192001518 aspartate-rich region 2; other site 760192001519 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 760192001520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192001521 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192001522 active site 760192001523 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192001524 Two component regulator propeller; Region: Reg_prop; pfam07494 760192001525 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192001526 Histidine kinase; Region: His_kinase; pfam06580 760192001527 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 760192001528 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192001529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192001530 active site 760192001531 phosphorylation site [posttranslational modification] 760192001532 intermolecular recognition site; other site 760192001533 dimerization interface [polypeptide binding]; other site 760192001534 LytTr DNA-binding domain; Region: LytTR; smart00850 760192001535 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192001536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192001537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192001538 DNA binding residues [nucleotide binding] 760192001539 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 760192001540 putative hydrophobic ligand binding site [chemical binding]; other site 760192001541 Uncharacterized conserved protein [Function unknown]; Region: COG2353 760192001542 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 760192001543 ArsC family; Region: ArsC; pfam03960 760192001544 putative catalytic residues [active] 760192001545 Prostaglandin dehydrogenases; Region: PGDH; cd05288 760192001546 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 760192001547 NAD(P) binding site [chemical binding]; other site 760192001548 substrate binding site [chemical binding]; other site 760192001549 dimer interface [polypeptide binding]; other site 760192001550 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192001551 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192001552 ligand binding site [chemical binding]; other site 760192001553 Winged helix-turn helix; Region: HTH_29; pfam13551 760192001554 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192001555 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 760192001556 Uncharacterized conserved protein [Function unknown]; Region: COG1434 760192001557 putative active site [active] 760192001558 Rhomboid family; Region: Rhomboid; cl11446 760192001559 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 760192001560 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192001561 active site 760192001562 Family description; Region: VCBS; pfam13517 760192001563 Family description; Region: VCBS; pfam13517 760192001564 Family description; Region: VCBS; pfam13517 760192001565 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 760192001566 Family description; Region: VCBS; pfam13517 760192001567 Family description; Region: VCBS; pfam13517 760192001568 Family description; Region: VCBS; pfam13517 760192001569 Family description; Region: VCBS; pfam13517 760192001570 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192001571 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192001572 SusD family; Region: SusD; pfam07980 760192001573 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192001574 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192001575 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192001576 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 760192001577 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192001578 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 760192001579 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760192001580 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760192001581 protein binding site [polypeptide binding]; other site 760192001582 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 760192001583 Domain interface; other site 760192001584 Active site tetrad [active] 760192001585 Peptide binding site; other site 760192001586 Cytochrome c; Region: Cytochrom_C; pfam00034 760192001587 OPT oligopeptide transporter protein; Region: OPT; cl14607 760192001588 putative oligopeptide transporter, OPT family; Region: TIGR00733 760192001589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192001590 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 760192001591 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 760192001592 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760192001593 DXD motif; other site 760192001594 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 760192001595 Phosphoglycerate kinase; Region: PGK; pfam00162 760192001596 substrate binding site [chemical binding]; other site 760192001597 hinge regions; other site 760192001598 ADP binding site [chemical binding]; other site 760192001599 catalytic site [active] 760192001600 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 760192001601 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 760192001602 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 760192001603 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 760192001604 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 760192001605 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 760192001606 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 760192001607 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 760192001608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192001609 PAS domain; Region: PAS_9; pfam13426 760192001610 putative active site [active] 760192001611 heme pocket [chemical binding]; other site 760192001612 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 760192001613 cyclase homology domain; Region: CHD; cd07302 760192001614 nucleotidyl binding site; other site 760192001615 metal binding site [ion binding]; metal-binding site 760192001616 dimer interface [polypeptide binding]; other site 760192001617 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 760192001618 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192001619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192001620 Walker A/P-loop; other site 760192001621 ATP binding site [chemical binding]; other site 760192001622 Q-loop/lid; other site 760192001623 ABC transporter signature motif; other site 760192001624 Walker B; other site 760192001625 D-loop; other site 760192001626 H-loop/switch region; other site 760192001627 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 760192001628 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 760192001629 putative active site [active] 760192001630 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192001631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192001632 Walker A/P-loop; other site 760192001633 ATP binding site [chemical binding]; other site 760192001634 Q-loop/lid; other site 760192001635 ABC transporter signature motif; other site 760192001636 Walker B; other site 760192001637 D-loop; other site 760192001638 H-loop/switch region; other site 760192001639 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 760192001640 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192001641 Outer membrane efflux protein; Region: OEP; pfam02321 760192001642 Outer membrane efflux protein; Region: OEP; pfam02321 760192001643 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192001644 ligand binding site [chemical binding]; other site 760192001645 flexible hinge region; other site 760192001646 active site 760192001647 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 760192001648 active site 760192001649 Methyltransferase domain; Region: Methyltransf_24; pfam13578 760192001650 Methyltransferase domain; Region: Methyltransf_24; pfam13578 760192001651 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760192001652 active site 760192001653 ecdysteroid UDP-glucosyltransferase; Provisional; Region: egt; PHA03392 760192001654 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 760192001655 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 760192001656 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 760192001657 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192001658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192001659 Methyltransferase domain; Region: Methyltransf_31; pfam13847 760192001660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192001661 S-adenosylmethionine binding site [chemical binding]; other site 760192001662 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 760192001663 SET domain; Region: SET; pfam00856 760192001664 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 760192001665 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 760192001666 active site 760192001667 catalytic residues [active] 760192001668 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192001669 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 760192001670 putative active site [active] 760192001671 Zn binding site [ion binding]; other site 760192001672 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 760192001673 conserved cys residue [active] 760192001674 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 760192001675 Peptidase family M28; Region: Peptidase_M28; pfam04389 760192001676 putative metal binding site [ion binding]; other site 760192001677 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192001678 Interdomain contacts; other site 760192001679 Cytokine receptor motif; other site 760192001680 CHAT domain; Region: CHAT; pfam12770 760192001681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192001682 TPR motif; other site 760192001683 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192001684 binding surface 760192001685 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192001686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192001687 binding surface 760192001688 TPR motif; other site 760192001689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192001690 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192001691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192001692 binding surface 760192001693 TPR motif; other site 760192001694 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192001695 LytTr DNA-binding domain; Region: LytTR; pfam04397 760192001696 amino acid transporter; Region: 2A0306; TIGR00909 760192001697 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 760192001698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 760192001699 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192001700 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192001701 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192001702 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 760192001703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192001704 putative substrate translocation pore; other site 760192001705 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 760192001706 Putative cyclase; Region: Cyclase; pfam04199 760192001707 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 760192001708 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192001709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192001710 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192001711 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192001712 active site 760192001713 catalytic tetrad [active] 760192001714 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192001715 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 760192001716 Carboxylesterase family; Region: COesterase; pfam00135 760192001717 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192001718 substrate binding pocket [chemical binding]; other site 760192001719 catalytic triad [active] 760192001720 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192001721 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192001722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192001723 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 760192001724 catalytic site [active] 760192001725 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 760192001726 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 760192001727 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192001728 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192001729 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 760192001730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192001731 catalytic loop [active] 760192001732 iron binding site [ion binding]; other site 760192001733 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 760192001734 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 760192001735 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192001736 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 760192001737 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192001738 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192001739 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 760192001740 AMP-binding domain protein; Validated; Region: PRK08315 760192001741 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 760192001742 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 760192001743 acyl-activating enzyme (AAE) consensus motif; other site 760192001744 acyl-activating enzyme (AAE) consensus motif; other site 760192001745 putative AMP binding site [chemical binding]; other site 760192001746 putative active site [active] 760192001747 putative CoA binding site [chemical binding]; other site 760192001748 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192001749 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192001750 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192001751 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192001752 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 760192001753 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192001754 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 760192001755 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 760192001756 active site pocket [active] 760192001757 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 760192001758 Cupin domain; Region: Cupin_2; pfam07883 760192001759 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 760192001760 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 760192001761 Strictosidine synthase; Region: Str_synth; pfam03088 760192001762 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 760192001763 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 760192001764 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 760192001765 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192001766 Cupin domain; Region: Cupin_2; pfam07883 760192001767 Cupin domain; Region: Cupin_2; cl17218 760192001768 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 760192001769 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 760192001770 Trp docking motif [polypeptide binding]; other site 760192001771 active site 760192001772 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 760192001773 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192001774 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 760192001775 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 760192001776 oligomeric interface; other site 760192001777 putative active site [active] 760192001778 homodimer interface [polypeptide binding]; other site 760192001779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192001780 AAA domain; Region: AAA_21; pfam13304 760192001781 Walker A/P-loop; other site 760192001782 ATP binding site [chemical binding]; other site 760192001783 AAA domain; Region: AAA_21; pfam13304 760192001784 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192001785 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192001786 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192001787 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192001788 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192001789 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192001790 Asp-box motif; other site 760192001791 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 760192001792 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192001793 LemA family; Region: LemA; cl00742 760192001794 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192001795 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192001796 aminoacyl-tRNA ligase; Region: PLN02563 760192001797 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 760192001798 HIGH motif; other site 760192001799 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 760192001800 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760192001801 active site 760192001802 KMSKS motif; other site 760192001803 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760192001804 active site 760192001805 KMSKS motif; other site 760192001806 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 760192001807 tRNA binding surface [nucleotide binding]; other site 760192001808 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 760192001809 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192001810 Interdomain contacts; other site 760192001811 Cytokine receptor motif; other site 760192001812 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 760192001813 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192001814 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192001815 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192001816 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192001817 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192001818 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192001819 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192001820 AAA ATPase domain; Region: AAA_16; pfam13191 760192001821 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 760192001822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192001823 Walker A/P-loop; other site 760192001824 ATP binding site [chemical binding]; other site 760192001825 Q-loop/lid; other site 760192001826 ABC transporter signature motif; other site 760192001827 Walker B; other site 760192001828 D-loop; other site 760192001829 H-loop/switch region; other site 760192001830 ABC transporter; Region: ABC_tran_2; pfam12848 760192001831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760192001832 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760192001833 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760192001834 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760192001835 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 760192001836 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 760192001837 dihydroxy-acid dehydratase; Validated; Region: PRK06131 760192001838 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 760192001839 classical (c) SDRs; Region: SDR_c; cd05233 760192001840 NAD(P) binding site [chemical binding]; other site 760192001841 active site 760192001842 GxxExxY protein; Region: GxxExxY; TIGR04256 760192001843 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 760192001844 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 760192001845 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760192001846 Catalytic site [active] 760192001847 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 760192001848 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 760192001849 active site 760192001850 DNA binding site [nucleotide binding] 760192001851 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 760192001852 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192001853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 760192001854 DinB superfamily; Region: DinB_2; pfam12867 760192001855 NUC194 domain; Region: NUC194; pfam08163 760192001856 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 760192001857 HsdM N-terminal domain; Region: HsdM_N; pfam12161 760192001858 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760192001859 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760192001860 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 760192001861 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760192001862 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 760192001863 Fic/DOC family; Region: Fic; pfam02661 760192001864 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 760192001865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760192001866 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192001867 putative Mg++ binding site [ion binding]; other site 760192001868 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 760192001869 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 760192001870 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192001871 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192001872 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 760192001873 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 760192001874 acyl-activating enzyme (AAE) consensus motif; other site 760192001875 AMP binding site [chemical binding]; other site 760192001876 active site 760192001877 CoA binding site [chemical binding]; other site 760192001878 Protein of unknown function (DUF1012); Region: DUF1012; pfam06241 760192001879 TrkA-N domain; Region: TrkA_N; pfam02254 760192001880 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 760192001881 Double zinc ribbon; Region: DZR; pfam12773 760192001882 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 760192001883 Subunit I/III interface [polypeptide binding]; other site 760192001884 DinB superfamily; Region: DinB_2; pfam12867 760192001885 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192001886 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192001887 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192001888 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 760192001889 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192001890 helicase 45; Provisional; Region: PTZ00424 760192001891 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 760192001892 ATP binding site [chemical binding]; other site 760192001893 Mg++ binding site [ion binding]; other site 760192001894 motif III; other site 760192001895 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192001896 nucleotide binding region [chemical binding]; other site 760192001897 ATP-binding site [chemical binding]; other site 760192001898 GntP family permease; Region: GntP_permease; pfam02447 760192001899 fructuronate transporter; Provisional; Region: PRK10034; cl15264 760192001900 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192001901 COG (conserved oligomeric Golgi) complex component, COG2; Region: COG2; pfam06148 760192001902 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760192001903 active site 760192001904 Int/Topo IB signature motif; other site 760192001905 DNA binding site [nucleotide binding] 760192001906 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 760192001907 Replication initiation factor; Region: Rep_trans; pfam02486 760192001908 Helix-turn-helix domain; Region: HTH_17; pfam12728 760192001909 Amidinotransferase; Region: Amidinotransf; cl12043 760192001910 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 760192001911 active site 760192001912 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 760192001913 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 760192001914 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192001915 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192001916 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 760192001917 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760192001918 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760192001919 protein binding site [polypeptide binding]; other site 760192001920 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 760192001921 Domain interface; other site 760192001922 Peptide binding site; other site 760192001923 Active site tetrad [active] 760192001924 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 760192001925 ParB-like nuclease domain; Region: ParBc; pfam02195 760192001926 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 760192001927 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760192001928 P-loop; other site 760192001929 Magnesium ion binding site [ion binding]; other site 760192001930 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760192001931 Magnesium ion binding site [ion binding]; other site 760192001932 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 760192001933 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 760192001934 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 760192001935 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192001936 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192001937 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 760192001938 DinB family; Region: DinB; cl17821 760192001939 DinB superfamily; Region: DinB_2; pfam12867 760192001940 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 760192001941 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 760192001942 active site clefts [active] 760192001943 zinc binding site [ion binding]; other site 760192001944 dimer interface [polypeptide binding]; other site 760192001945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 760192001946 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 760192001947 Mechanosensitive ion channel; Region: MS_channel; pfam00924 760192001948 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 760192001949 MerC mercury resistance protein; Region: MerC; pfam03203 760192001950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 760192001951 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 760192001952 Mechanosensitive ion channel; Region: MS_channel; pfam00924 760192001953 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 760192001954 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 760192001955 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 760192001956 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 760192001957 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 760192001958 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 760192001959 dimer interface [polypeptide binding]; other site 760192001960 substrate binding site [chemical binding]; other site 760192001961 metal binding sites [ion binding]; metal-binding site 760192001962 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 760192001963 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 760192001964 putative Cl- selectivity filter; other site 760192001965 putative pore gating glutamate residue; other site 760192001966 recombination factor protein RarA; Reviewed; Region: PRK13342 760192001967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192001968 Walker A motif; other site 760192001969 ATP binding site [chemical binding]; other site 760192001970 Walker B motif; other site 760192001971 arginine finger; other site 760192001972 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 760192001973 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 760192001974 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 760192001975 active site 760192001976 NTP binding site [chemical binding]; other site 760192001977 metal binding triad [ion binding]; metal-binding site 760192001978 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 760192001979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760192001980 Zn2+ binding site [ion binding]; other site 760192001981 Mg2+ binding site [ion binding]; other site 760192001982 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 760192001983 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 760192001984 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 760192001985 FMN binding site [chemical binding]; other site 760192001986 active site 760192001987 catalytic residues [active] 760192001988 substrate binding site [chemical binding]; other site 760192001989 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 760192001990 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 760192001991 active site 760192001992 dinuclear metal binding site [ion binding]; other site 760192001993 dimerization interface [polypeptide binding]; other site 760192001994 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192001995 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760192001996 Walker A/P-loop; other site 760192001997 ATP binding site [chemical binding]; other site 760192001998 Q-loop/lid; other site 760192001999 ABC transporter signature motif; other site 760192002000 Walker B; other site 760192002001 D-loop; other site 760192002002 H-loop/switch region; other site 760192002003 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 760192002004 GTP cyclohydrolase I; Provisional; Region: PLN03044 760192002005 active site 760192002006 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 760192002007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192002008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192002009 K+ potassium transporter; Region: K_trans; pfam02705 760192002010 Protein of unknown function (DUF721); Region: DUF721; pfam05258 760192002011 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 760192002012 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 760192002013 transmembrane helices; other site 760192002014 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 760192002015 TrkA-C domain; Region: TrkA_C; pfam02080 760192002016 TrkA-C domain; Region: TrkA_C; pfam02080 760192002017 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 760192002018 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 760192002019 DNA photolyase; Region: DNA_photolyase; pfam00875 760192002020 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 760192002021 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 760192002022 Ligand Binding Site [chemical binding]; other site 760192002023 TilS substrate C-terminal domain; Region: TilS_C; smart00977 760192002024 Outer membrane protein Omp28; Region: Omp28; pfam11551 760192002025 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 760192002026 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 760192002027 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760192002028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192002029 NAD(P) binding site [chemical binding]; other site 760192002030 active site 760192002031 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 760192002032 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 760192002033 substrate-cofactor binding pocket; other site 760192002034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192002035 catalytic residue [active] 760192002036 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 760192002037 four helix bundle protein; Region: TIGR02436 760192002038 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192002039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192002040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192002041 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 760192002042 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 760192002043 TolA protein; Region: tolA_full; TIGR02794 760192002044 Penicillinase repressor; Region: Pencillinase_R; cl17580 760192002045 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 760192002046 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 760192002047 active site 760192002048 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192002049 malate dehydrogenase; Reviewed; Region: PRK06223 760192002050 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 760192002051 NAD(P) binding site [chemical binding]; other site 760192002052 dimer interface [polypeptide binding]; other site 760192002053 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760192002054 substrate binding site [chemical binding]; other site 760192002055 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 760192002056 putative catalytic residues [active] 760192002057 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 760192002058 metal ion-dependent adhesion site (MIDAS); other site 760192002059 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 760192002060 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 760192002061 Winged helix-turn helix; Region: HTH_29; pfam13551 760192002062 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192002063 Uncharacterized conserved protein [Function unknown]; Region: COG3268 760192002064 Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...; Region: Ribosomal_L32_L32e; cl00748 760192002065 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 760192002066 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 760192002067 HSP70 interaction site [polypeptide binding]; other site 760192002068 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 760192002069 dimer interface [polypeptide binding]; other site 760192002070 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 760192002071 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 760192002072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192002073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192002074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192002075 Walker A/P-loop; other site 760192002076 ATP binding site [chemical binding]; other site 760192002077 Q-loop/lid; other site 760192002078 ABC transporter signature motif; other site 760192002079 Walker B; other site 760192002080 D-loop; other site 760192002081 H-loop/switch region; other site 760192002082 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 760192002083 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 760192002084 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760192002085 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 760192002086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192002087 motif II; other site 760192002088 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 760192002089 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192002090 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 760192002091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192002092 S-adenosylmethionine binding site [chemical binding]; other site 760192002093 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 760192002094 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 760192002095 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192002096 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 760192002097 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192002098 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 760192002099 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192002100 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192002101 active site 760192002102 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 760192002103 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 760192002104 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 760192002105 TPR repeat; Region: TPR_11; pfam13414 760192002106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002107 TPR motif; other site 760192002108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192002109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192002110 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 760192002111 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 760192002112 substrate binding site [chemical binding]; other site 760192002113 tetramer interface [polypeptide binding]; other site 760192002114 catalytic residue [active] 760192002115 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 760192002116 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 760192002117 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192002118 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192002119 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 760192002120 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760192002121 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 760192002122 Domain interface; other site 760192002123 Peptide binding site; other site 760192002124 Active site tetrad [active] 760192002125 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 760192002126 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 760192002127 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 760192002128 enterobactin exporter EntS; Provisional; Region: PRK10489 760192002129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192002130 putative substrate translocation pore; other site 760192002131 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 760192002132 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192002133 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192002134 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192002135 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192002136 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192002137 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 760192002138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192002139 Coenzyme A binding pocket [chemical binding]; other site 760192002140 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 760192002141 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192002142 active site 760192002143 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192002144 Fatty acid desaturase; Region: FA_desaturase; pfam00487 760192002145 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 760192002146 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 760192002147 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 760192002148 Dienelactone hydrolase family; Region: DLH; pfam01738 760192002149 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 760192002150 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192002151 Predicted esterase [General function prediction only]; Region: COG0400 760192002152 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 760192002153 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 760192002154 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 760192002155 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 760192002156 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760192002157 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 760192002158 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 760192002159 SPFH domain / Band 7 family; Region: Band_7; pfam01145 760192002160 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192002161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192002162 active site 760192002163 phosphorylation site [posttranslational modification] 760192002164 intermolecular recognition site; other site 760192002165 dimerization interface [polypeptide binding]; other site 760192002166 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192002167 DNA binding site [nucleotide binding] 760192002168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192002169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760192002170 dimerization interface [polypeptide binding]; other site 760192002171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192002172 dimer interface [polypeptide binding]; other site 760192002173 phosphorylation site [posttranslational modification] 760192002174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192002175 ATP binding site [chemical binding]; other site 760192002176 Mg2+ binding site [ion binding]; other site 760192002177 G-X-G motif; other site 760192002178 FOG: CBS domain [General function prediction only]; Region: COG0517 760192002179 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 760192002180 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 760192002181 active site clefts [active] 760192002182 zinc binding site [ion binding]; other site 760192002183 dimer interface [polypeptide binding]; other site 760192002184 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 760192002185 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 760192002186 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 760192002187 Methyltransferase domain; Region: Methyltransf_31; pfam13847 760192002188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192002189 S-adenosylmethionine binding site [chemical binding]; other site 760192002190 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 760192002191 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 760192002192 malonyl-CoA binding site [chemical binding]; other site 760192002193 dimer interface [polypeptide binding]; other site 760192002194 active site 760192002195 product binding site; other site 760192002196 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 760192002197 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 760192002198 Bacitracin resistance protein BacA; Region: BacA; pfam02673 760192002199 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 760192002200 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 760192002201 RNA binding site [nucleotide binding]; other site 760192002202 active site 760192002203 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 760192002204 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 760192002205 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 760192002206 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 760192002207 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 760192002208 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 760192002209 dihydroorotase; Validated; Region: pyrC; PRK09357 760192002210 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192002211 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 760192002212 active site 760192002213 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 760192002214 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 760192002215 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 760192002216 Putative Catalytic site; other site 760192002217 DXD motif; other site 760192002218 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760192002219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192002220 NAD(P) binding site [chemical binding]; other site 760192002221 active site 760192002222 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192002223 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192002224 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 760192002225 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 760192002226 dimer interface [polypeptide binding]; other site 760192002227 active site 760192002228 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 760192002229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192002230 S-adenosylmethionine binding site [chemical binding]; other site 760192002231 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 760192002232 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192002233 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192002234 ligand binding site [chemical binding]; other site 760192002235 flexible hinge region; other site 760192002236 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760192002237 putative switch regulator; other site 760192002238 non-specific DNA interactions [nucleotide binding]; other site 760192002239 DNA binding site [nucleotide binding] 760192002240 sequence specific DNA binding site [nucleotide binding]; other site 760192002241 putative cAMP binding site [chemical binding]; other site 760192002242 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 760192002243 Secretin and TonB N terminus short domain; Region: STN; smart00965 760192002244 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192002245 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 760192002246 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192002247 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 760192002248 FecR protein; Region: FecR; pfam04773 760192002249 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 760192002250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192002251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192002252 DNA binding residues [nucleotide binding] 760192002253 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 760192002254 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 760192002255 active site 760192002256 Predicted permeases [General function prediction only]; Region: COG0795 760192002257 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 760192002258 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 760192002259 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 760192002260 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192002261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192002262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192002263 DNA binding residues [nucleotide binding] 760192002264 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 760192002265 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 760192002266 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 760192002267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 760192002268 Protein of unknown function (DUF819); Region: DUF819; cl02317 760192002269 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 760192002270 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192002271 Asp-box motif; other site 760192002272 catalytic site [active] 760192002273 SWIM zinc finger; Region: SWIM; pfam04434 760192002274 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 760192002275 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192002276 ATP binding site [chemical binding]; other site 760192002277 putative Mg++ binding site [ion binding]; other site 760192002278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192002279 nucleotide binding region [chemical binding]; other site 760192002280 ATP-binding site [chemical binding]; other site 760192002281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002282 binding surface 760192002283 TPR repeat; Region: TPR_11; pfam13414 760192002284 TPR motif; other site 760192002285 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 760192002286 protein binding site [polypeptide binding]; other site 760192002287 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760192002288 Active site serine [active] 760192002289 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192002290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192002291 non-specific DNA binding site [nucleotide binding]; other site 760192002292 salt bridge; other site 760192002293 sequence-specific DNA binding site [nucleotide binding]; other site 760192002294 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 760192002295 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192002296 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192002297 ligand binding site [chemical binding]; other site 760192002298 flexible hinge region; other site 760192002299 Putative cyclase; Region: Cyclase; pfam04199 760192002300 Protein of unknown function, DUF606; Region: DUF606; pfam04657 760192002301 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 760192002302 putative NAD(P) binding site [chemical binding]; other site 760192002303 homodimer interface [polypeptide binding]; other site 760192002304 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 760192002305 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 760192002306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002308 TPR motif; other site 760192002309 binding surface 760192002310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002312 binding surface 760192002313 TPR motif; other site 760192002314 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002315 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002317 binding surface 760192002318 TPR motif; other site 760192002319 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002320 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192002322 ATP binding site [chemical binding]; other site 760192002323 Mg2+ binding site [ion binding]; other site 760192002324 G-X-G motif; other site 760192002325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 760192002326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192002327 active site 760192002328 metal binding site [ion binding]; metal-binding site 760192002329 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192002331 dimer interface [polypeptide binding]; other site 760192002332 phosphorylation site [posttranslational modification] 760192002333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192002334 ATP binding site [chemical binding]; other site 760192002335 Mg2+ binding site [ion binding]; other site 760192002336 G-X-G motif; other site 760192002337 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192002338 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192002339 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192002340 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192002341 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 760192002342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192002343 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192002344 Walker A motif; other site 760192002345 ATP binding site [chemical binding]; other site 760192002346 Walker B motif; other site 760192002347 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 760192002348 Nuclease-related domain; Region: NERD; pfam08378 760192002349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002350 binding surface 760192002351 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002352 TPR motif; other site 760192002353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 760192002355 dimer interface [polypeptide binding]; other site 760192002356 phosphorylation site [posttranslational modification] 760192002357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192002358 ATP binding site [chemical binding]; other site 760192002359 Mg2+ binding site [ion binding]; other site 760192002360 G-X-G motif; other site 760192002361 UGMP family protein; Validated; Region: PRK09604 760192002362 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 760192002363 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 760192002364 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 760192002365 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 760192002366 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 760192002367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192002368 S-adenosylmethionine binding site [chemical binding]; other site 760192002369 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 760192002370 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 760192002371 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760192002372 active site 760192002373 HIGH motif; other site 760192002374 nucleotide binding site [chemical binding]; other site 760192002375 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 760192002376 KMSK motif region; other site 760192002377 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 760192002378 tRNA binding surface [nucleotide binding]; other site 760192002379 anticodon binding site; other site 760192002380 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 760192002381 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760192002382 active site 760192002383 HIGH motif; other site 760192002384 nucleotide binding site [chemical binding]; other site 760192002385 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 760192002386 KMSKS motif; other site 760192002387 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 760192002388 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 760192002389 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 760192002390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192002391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192002392 ATP binding site [chemical binding]; other site 760192002393 Mg2+ binding site [ion binding]; other site 760192002394 G-X-G motif; other site 760192002395 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192002396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192002397 active site 760192002398 phosphorylation site [posttranslational modification] 760192002399 intermolecular recognition site; other site 760192002400 dimerization interface [polypeptide binding]; other site 760192002401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192002402 DNA binding residues [nucleotide binding] 760192002403 dimerization interface [polypeptide binding]; other site 760192002404 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 760192002405 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 760192002406 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760192002407 active site 760192002408 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 760192002409 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 760192002410 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 760192002411 NlpE N-terminal domain; Region: NlpE; pfam04170 760192002412 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 760192002413 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 760192002414 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 760192002415 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 760192002416 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760192002417 Winged helix-turn helix; Region: HTH_29; pfam13551 760192002418 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192002419 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 760192002420 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192002421 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192002422 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 760192002423 substrate binding pocket [chemical binding]; other site 760192002424 Winged helix-turn helix; Region: HTH_29; pfam13551 760192002425 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192002426 PIN domain; Region: PIN; pfam01850 760192002427 NACHT domain; Region: NACHT; pfam05729 760192002428 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192002429 active site 760192002430 Uncharacterized conserved protein [Function unknown]; Region: COG2442 760192002431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192002432 short chain dehydrogenase; Provisional; Region: PRK06181 760192002433 NAD(P) binding site [chemical binding]; other site 760192002434 active site 760192002435 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192002436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192002437 active site 760192002438 phosphorylation site [posttranslational modification] 760192002439 intermolecular recognition site; other site 760192002440 dimerization interface [polypeptide binding]; other site 760192002441 LytTr DNA-binding domain; Region: LytTR; smart00850 760192002442 Histidine kinase; Region: His_kinase; pfam06580 760192002443 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192002444 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 760192002445 ligand binding site [chemical binding]; other site 760192002446 active site 760192002447 UGI interface [polypeptide binding]; other site 760192002448 catalytic site [active] 760192002449 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192002450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192002451 active site 760192002452 phosphorylation site [posttranslational modification] 760192002453 intermolecular recognition site; other site 760192002454 dimerization interface [polypeptide binding]; other site 760192002455 LytTr DNA-binding domain; Region: LytTR; smart00850 760192002456 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 760192002457 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 760192002458 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 760192002459 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192002460 putative active site [active] 760192002461 putative NTP binding site [chemical binding]; other site 760192002462 putative nucleic acid binding site [nucleotide binding]; other site 760192002463 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 760192002464 metal-dependent hydrolase; Provisional; Region: PRK13291 760192002465 DinB superfamily; Region: DinB_2; pfam12867 760192002466 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 760192002467 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 760192002468 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192002469 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 760192002470 dockerin binding interface; other site 760192002471 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192002472 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192002473 Leucine rich repeat; Region: LRR_8; pfam13855 760192002474 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192002475 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192002476 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192002477 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192002478 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192002479 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192002480 Protein of unknown function DUF86; Region: DUF86; cl01031 760192002481 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 760192002482 active site 760192002483 NTP binding site [chemical binding]; other site 760192002484 metal binding triad [ion binding]; metal-binding site 760192002485 antibiotic binding site [chemical binding]; other site 760192002486 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192002487 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192002488 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192002489 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 760192002490 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 760192002491 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 760192002492 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192002493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192002494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 760192002495 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 760192002496 active site 760192002497 catalytic residues [active] 760192002498 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 760192002499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002500 binding surface 760192002501 TPR motif; other site 760192002502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002503 binding surface 760192002504 TPR motif; other site 760192002505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002506 binding surface 760192002507 TPR motif; other site 760192002508 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002509 CHAT domain; Region: CHAT; pfam12770 760192002510 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192002511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192002512 active site 760192002513 phosphorylation site [posttranslational modification] 760192002514 intermolecular recognition site; other site 760192002515 dimerization interface [polypeptide binding]; other site 760192002516 LytTr DNA-binding domain; Region: LytTR; smart00850 760192002517 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 760192002518 Histidine kinase; Region: His_kinase; pfam06580 760192002519 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 760192002520 ATP binding site [chemical binding]; other site 760192002521 Mg2+ binding site [ion binding]; other site 760192002522 G-X-G motif; other site 760192002523 CARDB; Region: CARDB; pfam07705 760192002524 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 760192002525 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 760192002526 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 760192002527 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 760192002528 NodB motif; other site 760192002529 active site 760192002530 catalytic site [active] 760192002531 metal binding site [ion binding]; metal-binding site 760192002532 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 760192002533 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 760192002534 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192002535 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192002536 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192002537 mannonate dehydratase; Region: uxuA; TIGR00695 760192002538 mannonate dehydratase; Provisional; Region: PRK03906 760192002539 META domain; Region: META; cl01245 760192002540 DinB superfamily; Region: DinB_2; pfam12867 760192002541 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192002542 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192002543 ligand binding site [chemical binding]; other site 760192002544 flexible hinge region; other site 760192002545 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192002546 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192002547 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 760192002548 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192002549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192002550 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192002551 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192002552 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192002553 Asp-box motif; other site 760192002554 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 760192002555 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 760192002556 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 760192002557 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 760192002558 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 760192002559 Surface antigen; Region: Bac_surface_Ag; pfam01103 760192002560 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 760192002561 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 760192002562 minor groove reading motif; other site 760192002563 helix-hairpin-helix signature motif; other site 760192002564 substrate binding pocket [chemical binding]; other site 760192002565 active site 760192002566 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 760192002567 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 760192002568 dimerization interface [polypeptide binding]; other site 760192002569 ATP binding site [chemical binding]; other site 760192002570 Peptidase family M23; Region: Peptidase_M23; pfam01551 760192002571 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 760192002572 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 760192002573 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 760192002574 Histidine kinase; Region: His_kinase; pfam06580 760192002575 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192002576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192002577 active site 760192002578 phosphorylation site [posttranslational modification] 760192002579 intermolecular recognition site; other site 760192002580 dimerization interface [polypeptide binding]; other site 760192002581 LytTr DNA-binding domain; Region: LytTR; smart00850 760192002582 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192002583 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 760192002584 putative catalytic site [active] 760192002585 putative phosphate binding site [ion binding]; other site 760192002586 putative metal binding site [ion binding]; other site 760192002587 dihydrodipicolinate reductase; Provisional; Region: PRK00048 760192002588 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 760192002589 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 760192002590 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 760192002591 MutS domain I; Region: MutS_I; pfam01624 760192002592 MutS domain II; Region: MutS_II; pfam05188 760192002593 MutS domain III; Region: MutS_III; pfam05192 760192002594 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 760192002595 Walker A/P-loop; other site 760192002596 ATP binding site [chemical binding]; other site 760192002597 Q-loop/lid; other site 760192002598 ABC transporter signature motif; other site 760192002599 Walker B; other site 760192002600 D-loop; other site 760192002601 H-loop/switch region; other site 760192002602 4Fe-4S binding domain; Region: Fer4; pfam00037 760192002603 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002604 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002605 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192002607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192002608 dimer interface [polypeptide binding]; other site 760192002609 phosphorylation site [posttranslational modification] 760192002610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192002611 ATP binding site [chemical binding]; other site 760192002612 Mg2+ binding site [ion binding]; other site 760192002613 G-X-G motif; other site 760192002614 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 760192002615 active site 760192002616 catalytic residues [active] 760192002617 AIR carboxylase; Region: AIRC; pfam00731 760192002618 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 760192002619 YCII-related domain; Region: YCII; cl00999 760192002620 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192002621 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192002622 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192002623 dockerin binding interface; other site 760192002624 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192002625 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192002626 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192002627 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192002628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192002629 active site 760192002630 phosphorylation site [posttranslational modification] 760192002631 intermolecular recognition site; other site 760192002632 dimerization interface [polypeptide binding]; other site 760192002633 LytTr DNA-binding domain; Region: LytTR; smart00850 760192002634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192002635 Radical SAM superfamily; Region: Radical_SAM; pfam04055 760192002636 FeS/SAM binding site; other site 760192002637 coproporphyrinogen III oxidase; Validated; Region: PRK08208 760192002638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192002639 FeS/SAM binding site; other site 760192002640 HemN C-terminal domain; Region: HemN_C; pfam06969 760192002641 Sulfatase; Region: Sulfatase; cl17466 760192002642 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 760192002643 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 760192002644 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192002645 substrate binding pocket [chemical binding]; other site 760192002646 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 760192002647 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192002648 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192002649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 760192002650 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 760192002651 Putative glucoamylase; Region: Glycoamylase; pfam10091 760192002652 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192002653 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192002654 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192002655 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192002656 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192002657 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192002658 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192002659 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 760192002660 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 760192002661 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760192002662 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760192002663 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192002664 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192002665 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 760192002666 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192002667 active site 760192002668 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 760192002669 Uncharacterized conserved protein [Function unknown]; Region: COG3391 760192002670 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 760192002671 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192002672 RHS Repeat; Region: RHS_repeat; cl11982 760192002673 RHS Repeat; Region: RHS_repeat; cl11982 760192002674 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 760192002675 RHS Repeat; Region: RHS_repeat; pfam05593 760192002676 RHS Repeat; Region: RHS_repeat; pfam05593 760192002677 RHS Repeat; Region: RHS_repeat; pfam05593 760192002678 RHS Repeat; Region: RHS_repeat; pfam05593 760192002679 RHS Repeat; Region: RHS_repeat; pfam05593 760192002680 RHS Repeat; Region: RHS_repeat; pfam05593 760192002681 RHS Repeat; Region: RHS_repeat; pfam05593 760192002682 RHS Repeat; Region: RHS_repeat; pfam05593 760192002683 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 760192002684 RHS Repeat; Region: RHS_repeat; cl11982 760192002685 RHS protein; Region: RHS; pfam03527 760192002686 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192002687 Right handed beta helix region; Region: Beta_helix; pfam13229 760192002688 Right handed beta helix region; Region: Beta_helix; pfam13229 760192002689 CARDB; Region: CARDB; pfam07705 760192002690 CARDB; Region: CARDB; pfam07705 760192002691 Trehalose utilisation; Region: ThuA; pfam06283 760192002692 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 760192002693 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192002694 Cytochrome c; Region: Cytochrom_C; cl11414 760192002695 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 760192002696 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192002697 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760192002698 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 760192002699 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 760192002700 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 760192002701 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 760192002702 FMN binding site [chemical binding]; other site 760192002703 active site 760192002704 substrate binding site [chemical binding]; other site 760192002705 catalytic residue [active] 760192002706 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192002707 putative active site [active] 760192002708 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192002709 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192002710 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192002711 Histidine kinase; Region: His_kinase; pfam06580 760192002712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192002713 Response regulator receiver domain; Region: Response_reg; pfam00072 760192002714 active site 760192002715 phosphorylation site [posttranslational modification] 760192002716 intermolecular recognition site; other site 760192002717 dimerization interface [polypeptide binding]; other site 760192002718 LytTr DNA-binding domain; Region: LytTR; smart00850 760192002719 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192002720 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192002721 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192002722 putative active site [active] 760192002723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760192002724 DNA-binding site [nucleotide binding]; DNA binding site 760192002725 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760192002726 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 760192002727 putative dimerization interface [polypeptide binding]; other site 760192002728 putative ligand binding site [chemical binding]; other site 760192002729 short chain dehydrogenase; Validated; Region: PRK08324 760192002730 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 760192002731 active site 760192002732 Zn2+ binding site [ion binding]; other site 760192002733 intersubunit interface [polypeptide binding]; other site 760192002734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192002735 NAD(P) binding site [chemical binding]; other site 760192002736 active site 760192002737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 760192002738 Uncharacterized conserved protein [Function unknown]; Region: COG2442 760192002739 cell division protein FtsZ; Validated; Region: PRK09330 760192002740 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 760192002741 nucleotide binding site [chemical binding]; other site 760192002742 SulA interaction site; other site 760192002743 cell division protein FtsA; Region: ftsA; TIGR01174 760192002744 Cell division protein FtsA; Region: FtsA; smart00842 760192002745 Cell division protein FtsA; Region: FtsA; pfam14450 760192002746 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 760192002747 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 760192002748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760192002749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760192002750 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 760192002751 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 760192002752 active site 760192002753 homodimer interface [polypeptide binding]; other site 760192002754 cell division protein FtsW; Region: ftsW; TIGR02614 760192002755 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 760192002756 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 760192002757 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760192002758 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760192002759 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 760192002760 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 760192002761 Mg++ binding site [ion binding]; other site 760192002762 putative catalytic motif [active] 760192002763 putative substrate binding site [chemical binding]; other site 760192002764 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 760192002765 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 760192002766 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760192002767 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760192002768 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 760192002769 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 760192002770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 760192002771 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 760192002772 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 760192002773 MraW methylase family; Region: Methyltransf_5; cl17771 760192002774 MraZ protein; Region: MraZ; pfam02381 760192002775 cell division protein MraZ; Reviewed; Region: PRK00326 760192002776 MraZ protein; Region: MraZ; pfam02381 760192002777 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192002778 EamA-like transporter family; Region: EamA; pfam00892 760192002779 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 760192002780 EamA-like transporter family; Region: EamA; pfam00892 760192002781 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760192002782 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760192002783 Peptidase family M28; Region: Peptidase_M28; pfam04389 760192002784 metal binding site [ion binding]; metal-binding site 760192002785 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 760192002786 metal binding site [ion binding]; metal-binding site 760192002787 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 760192002788 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 760192002789 dimer interface [polypeptide binding]; other site 760192002790 active site 760192002791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760192002792 catalytic residues [active] 760192002793 substrate binding site [chemical binding]; other site 760192002794 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 760192002795 putative homodimer interface [polypeptide binding]; other site 760192002796 putative active site pocket [active] 760192002797 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 760192002798 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192002799 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192002800 structural tetrad; other site 760192002801 AAA ATPase domain; Region: AAA_16; pfam13191 760192002802 AAA ATPase domain; Region: AAA_16; pfam13191 760192002803 CHAT domain; Region: CHAT; cl17868 760192002804 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 760192002805 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 760192002806 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 760192002807 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 760192002808 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 760192002809 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 760192002810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192002811 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 760192002812 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 760192002813 active site 760192002814 dimer interface [polypeptide binding]; other site 760192002815 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 760192002816 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 760192002817 active site 760192002818 FMN binding site [chemical binding]; other site 760192002819 substrate binding site [chemical binding]; other site 760192002820 3Fe-4S cluster binding site [ion binding]; other site 760192002821 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 760192002822 domain interface; other site 760192002823 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 760192002824 putative active site [active] 760192002825 putative metal binding site [ion binding]; other site 760192002826 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192002827 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192002828 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192002829 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 760192002830 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 760192002831 metal binding site [ion binding]; metal-binding site 760192002832 putative dimer interface [polypeptide binding]; other site 760192002833 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 760192002834 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 760192002835 active site 760192002836 trimer interface [polypeptide binding]; other site 760192002837 allosteric site; other site 760192002838 active site lid [active] 760192002839 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 760192002840 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 760192002841 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192002842 2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239 760192002843 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192002844 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760192002845 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192002846 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192002847 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760192002848 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192002849 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 760192002850 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192002851 putative active site [active] 760192002852 putative NTP binding site [chemical binding]; other site 760192002853 putative nucleic acid binding site [nucleotide binding]; other site 760192002854 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 760192002855 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 760192002856 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 760192002857 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 760192002858 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 760192002859 protein binding site [polypeptide binding]; other site 760192002860 Cytochrome c; Region: Cytochrom_C; pfam00034 760192002861 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 760192002862 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192002863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192002864 active site 760192002865 phosphorylation site [posttranslational modification] 760192002866 intermolecular recognition site; other site 760192002867 dimerization interface [polypeptide binding]; other site 760192002868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192002869 dimerization interface [polypeptide binding]; other site 760192002870 DNA binding residues [nucleotide binding] 760192002871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002872 TPR motif; other site 760192002873 binding surface 760192002874 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002875 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192002876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192002877 binding surface 760192002878 TPR motif; other site 760192002879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192002880 Histidine kinase; Region: HisKA_3; pfam07730 760192002881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192002882 ATP binding site [chemical binding]; other site 760192002883 Mg2+ binding site [ion binding]; other site 760192002884 G-X-G motif; other site 760192002885 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 760192002886 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 760192002887 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 760192002888 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 760192002889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 760192002890 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 760192002891 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 760192002892 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 760192002893 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192002894 MarC family integral membrane protein; Region: MarC; cl00919 760192002895 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 760192002896 classical (c) SDRs; Region: SDR_c; cd05233 760192002897 NAD(P) binding site [chemical binding]; other site 760192002898 active site 760192002899 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 760192002900 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 760192002901 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192002902 HYR domain; Region: HYR; pfam02494 760192002903 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 760192002904 dockerin binding interface; other site 760192002905 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192002906 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760192002907 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192002908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192002909 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 760192002910 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 760192002911 inhibitor site; inhibition site 760192002912 active site 760192002913 dimer interface [polypeptide binding]; other site 760192002914 catalytic residue [active] 760192002915 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 760192002916 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 760192002917 dimer interface [polypeptide binding]; other site 760192002918 NADP binding site [chemical binding]; other site 760192002919 catalytic residues [active] 760192002920 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 760192002921 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 760192002922 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 760192002923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192002924 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 760192002925 AAA ATPase domain; Region: AAA_16; pfam13191 760192002926 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192002927 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 760192002928 active site 760192002929 catalytic triad [active] 760192002930 oxyanion hole [active] 760192002931 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 760192002932 AMP binding site [chemical binding]; other site 760192002933 metal binding site [ion binding]; metal-binding site 760192002934 active site 760192002935 Leucine rich repeat; Region: LRR_8; pfam13855 760192002936 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 760192002937 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192002938 G1 box; other site 760192002939 GTP/Mg2+ binding site [chemical binding]; other site 760192002940 G2 box; other site 760192002941 Switch I region; other site 760192002942 G3 box; other site 760192002943 Switch II region; other site 760192002944 G4 box; other site 760192002945 G5 box; other site 760192002946 CHAT domain; Region: CHAT; cl17868 760192002947 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192002948 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192002949 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192002950 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192002951 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192002952 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192002953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192002954 Walker A/P-loop; other site 760192002955 ATP binding site [chemical binding]; other site 760192002956 Q-loop/lid; other site 760192002957 ABC transporter signature motif; other site 760192002958 Walker B; other site 760192002959 D-loop; other site 760192002960 H-loop/switch region; other site 760192002961 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 760192002962 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192002963 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192002964 protein binding site [polypeptide binding]; other site 760192002965 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192002966 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192002967 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192002968 putative active site [active] 760192002969 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 760192002970 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192002971 putative active site [active] 760192002972 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192002973 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 760192002974 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192002975 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192002976 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192002977 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192002978 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192002979 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192002980 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 760192002981 Penicillinase repressor; Region: Pencillinase_R; cl17580 760192002982 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 760192002983 GldM C-terminal domain; Region: GldM_C; pfam12080 760192002984 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 760192002985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 760192002986 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 760192002987 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 760192002988 putative active site [active] 760192002989 metal binding site [ion binding]; metal-binding site 760192002990 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 760192002991 active site 760192002992 Zn binding site [ion binding]; other site 760192002993 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 760192002994 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 760192002995 active site 760192002996 substrate binding site [chemical binding]; other site 760192002997 metal binding site [ion binding]; metal-binding site 760192002998 Bacterial SH3 domain; Region: SH3_3; cl17532 760192002999 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 760192003000 AAA domain; Region: AAA_11; pfam13086 760192003001 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192003002 ATP binding site [chemical binding]; other site 760192003003 putative Mg++ binding site [ion binding]; other site 760192003004 AAA domain; Region: AAA_12; pfam13087 760192003005 PIN domain; Region: PIN_3; cl17397 760192003006 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 760192003007 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 760192003008 GAF domain; Region: GAF_2; pfam13185 760192003009 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 760192003010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192003011 Coenzyme A binding pocket [chemical binding]; other site 760192003012 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 760192003013 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 760192003014 active site 760192003015 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192003016 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192003017 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 760192003018 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 760192003019 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 760192003020 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 760192003021 Ligand binding site; other site 760192003022 metal-binding site 760192003023 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 760192003024 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192003025 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 760192003026 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192003027 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 760192003028 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 760192003029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192003030 S-adenosylmethionine binding site [chemical binding]; other site 760192003031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 760192003032 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 760192003033 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192003034 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192003035 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192003036 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760192003037 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760192003038 nucleotide binding site [chemical binding]; other site 760192003039 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192003040 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192003041 Transposase; Region: DEDD_Tnp_IS110; pfam01548 760192003042 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 760192003043 Bacterial Ig-like domain; Region: Big_5; pfam13205 760192003044 Bacterial Ig-like domain; Region: Big_5; pfam13205 760192003045 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 760192003046 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 760192003047 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 760192003048 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 760192003049 putative active site [active] 760192003050 Zn binding site [ion binding]; other site 760192003051 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 760192003052 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 760192003053 dimer interface [polypeptide binding]; other site 760192003054 putative anticodon binding site; other site 760192003055 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 760192003056 motif 1; other site 760192003057 active site 760192003058 motif 2; other site 760192003059 motif 3; other site 760192003060 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 760192003061 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 760192003062 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 760192003063 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 760192003064 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 760192003065 NADP binding site [chemical binding]; other site 760192003066 active site 760192003067 putative substrate binding site [chemical binding]; other site 760192003068 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 760192003069 GTP-binding protein Der; Reviewed; Region: PRK00093 760192003070 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 760192003071 G1 box; other site 760192003072 GTP/Mg2+ binding site [chemical binding]; other site 760192003073 Switch I region; other site 760192003074 G2 box; other site 760192003075 Switch II region; other site 760192003076 G3 box; other site 760192003077 G4 box; other site 760192003078 G5 box; other site 760192003079 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 760192003080 G1 box; other site 760192003081 GTP/Mg2+ binding site [chemical binding]; other site 760192003082 Switch I region; other site 760192003083 G2 box; other site 760192003084 G3 box; other site 760192003085 Switch II region; other site 760192003086 G4 box; other site 760192003087 G5 box; other site 760192003088 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 760192003089 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 760192003090 Histidine kinase; Region: His_kinase; pfam06580 760192003091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192003092 ATP binding site [chemical binding]; other site 760192003093 Mg2+ binding site [ion binding]; other site 760192003094 G-X-G motif; other site 760192003095 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192003096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003097 active site 760192003098 phosphorylation site [posttranslational modification] 760192003099 intermolecular recognition site; other site 760192003100 dimerization interface [polypeptide binding]; other site 760192003101 LytTr DNA-binding domain; Region: LytTR; smart00850 760192003102 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 760192003103 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192003104 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 760192003105 Lumazine binding domain; Region: Lum_binding; pfam00677 760192003106 Lumazine binding domain; Region: Lum_binding; pfam00677 760192003107 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760192003108 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 760192003109 ligand binding site [chemical binding]; other site 760192003110 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760192003111 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760192003112 TM-ABC transporter signature motif; other site 760192003113 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760192003114 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760192003115 Walker A/P-loop; other site 760192003116 ATP binding site [chemical binding]; other site 760192003117 Q-loop/lid; other site 760192003118 ABC transporter signature motif; other site 760192003119 Walker B; other site 760192003120 D-loop; other site 760192003121 H-loop/switch region; other site 760192003122 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760192003123 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192003124 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192003125 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192003126 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 760192003127 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 760192003128 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 760192003129 putative active site [active] 760192003130 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 760192003131 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192003132 Cupin domain; Region: Cupin_2; cl17218 760192003133 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192003134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192003135 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 760192003136 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 760192003137 Bacterial sugar transferase; Region: Bac_transf; pfam02397 760192003138 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192003139 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192003140 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192003141 Ferritin-like domain; Region: Ferritin_2; pfam13668 760192003142 Ferritin-like domain; Region: Ferritin_2; pfam13668 760192003143 Double zinc ribbon; Region: DZR; pfam12773 760192003144 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 760192003145 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 760192003146 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 760192003147 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192003148 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192003149 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 760192003150 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 760192003151 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 760192003152 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 760192003153 active site 760192003154 putative transposase OrfB; Reviewed; Region: PHA02517 760192003155 Integrase core domain; Region: rve; pfam00665 760192003156 Integrase core domain; Region: rve_3; pfam13683 760192003157 YceI-like domain; Region: YceI; pfam04264 760192003158 YceI-like domain; Region: YceI; pfam04264 760192003159 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192003160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192003161 catalytic residue [active] 760192003162 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 760192003163 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 760192003164 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192003165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003166 active site 760192003167 phosphorylation site [posttranslational modification] 760192003168 intermolecular recognition site; other site 760192003169 dimerization interface [polypeptide binding]; other site 760192003170 LytTr DNA-binding domain; Region: LytTR; smart00850 760192003171 Histidine kinase; Region: His_kinase; pfam06580 760192003172 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 760192003173 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 760192003174 CHAT domain; Region: CHAT; cl17868 760192003175 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192003176 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192003177 structural tetrad; other site 760192003178 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192003179 structural tetrad; other site 760192003180 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192003181 structural tetrad; other site 760192003182 Predicted amidohydrolase [General function prediction only]; Region: COG0388 760192003183 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 760192003184 putative active site [active] 760192003185 catalytic triad [active] 760192003186 putative dimer interface [polypeptide binding]; other site 760192003187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192003188 Coenzyme A binding pocket [chemical binding]; other site 760192003189 Fasciclin domain; Region: Fasciclin; pfam02469 760192003190 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 760192003191 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 760192003192 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 760192003193 trimerization site [polypeptide binding]; other site 760192003194 active site 760192003195 cysteine desulfurase; Provisional; Region: PRK14012 760192003196 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 760192003197 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192003198 catalytic residue [active] 760192003199 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 760192003200 active site 760192003201 catalytic residues [active] 760192003202 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192003203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192003204 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192003205 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192003206 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 760192003207 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 760192003208 metal binding site 2 [ion binding]; metal-binding site 760192003209 putative DNA binding helix; other site 760192003210 metal binding site 1 [ion binding]; metal-binding site 760192003211 dimer interface [polypeptide binding]; other site 760192003212 structural Zn2+ binding site [ion binding]; other site 760192003213 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192003214 putative active site [active] 760192003215 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003216 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192003217 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192003218 N-terminal plug; other site 760192003219 ligand-binding site [chemical binding]; other site 760192003220 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 760192003221 TPR repeat; Region: TPR_11; pfam13414 760192003222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192003223 binding surface 760192003224 TPR motif; other site 760192003225 TPR repeat; Region: TPR_11; pfam13414 760192003226 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 760192003227 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192003228 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192003229 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192003230 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192003231 ligand binding site [chemical binding]; other site 760192003232 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 760192003233 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 760192003234 active site 760192003235 putative substrate binding pocket [chemical binding]; other site 760192003236 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192003237 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003238 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192003239 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192003240 N-terminal plug; other site 760192003241 ligand-binding site [chemical binding]; other site 760192003242 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003243 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192003244 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 760192003245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 760192003246 substrate binding site [chemical binding]; other site 760192003247 oxyanion hole (OAH) forming residues; other site 760192003248 trimer interface [polypeptide binding]; other site 760192003249 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 760192003250 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 760192003251 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 760192003252 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 760192003253 dimer interface [polypeptide binding]; other site 760192003254 active site 760192003255 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 760192003256 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 760192003257 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 760192003258 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192003259 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 760192003260 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192003261 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192003262 protein binding site [polypeptide binding]; other site 760192003263 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192003264 protein binding site [polypeptide binding]; other site 760192003265 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 760192003266 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 760192003267 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 760192003268 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 760192003269 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192003270 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192003271 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 760192003272 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 760192003273 tetramer interface [polypeptide binding]; other site 760192003274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192003275 catalytic residue [active] 760192003276 Bacterial PH domain; Region: DUF304; cl01348 760192003277 Bacterial PH domain; Region: DUF304; pfam03703 760192003278 Bacterial PH domain; Region: DUF304; pfam03703 760192003279 Bacterial PH domain; Region: DUF304; pfam03703 760192003280 Src Homology 3 domain superfamily; Region: SH3; cl17036 760192003281 peptide ligand binding site [polypeptide binding]; other site 760192003282 Uncharacterized conserved protein [Function unknown]; Region: COG3391 760192003283 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 760192003284 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 760192003285 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 760192003286 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 760192003287 putative active site [active] 760192003288 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003289 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 760192003290 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192003291 N-terminal plug; other site 760192003292 ligand-binding site [chemical binding]; other site 760192003293 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 760192003294 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192003295 active site 760192003296 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192003297 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760192003298 active site 760192003299 metal binding site [ion binding]; metal-binding site 760192003300 fumarate hydratase; Reviewed; Region: fumC; PRK00485 760192003301 Class II fumarases; Region: Fumarase_classII; cd01362 760192003302 active site 760192003303 tetramer interface [polypeptide binding]; other site 760192003304 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 760192003305 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 760192003306 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 760192003307 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192003308 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192003309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003310 active site 760192003311 phosphorylation site [posttranslational modification] 760192003312 intermolecular recognition site; other site 760192003313 dimerization interface [polypeptide binding]; other site 760192003314 LytTr DNA-binding domain; Region: LytTR; smart00850 760192003315 Histidine kinase; Region: His_kinase; pfam06580 760192003316 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192003317 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760192003318 Walker A/P-loop; other site 760192003319 ATP binding site [chemical binding]; other site 760192003320 Q-loop/lid; other site 760192003321 ABC transporter signature motif; other site 760192003322 Walker B; other site 760192003323 D-loop; other site 760192003324 H-loop/switch region; other site 760192003325 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 760192003326 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192003327 FtsX-like permease family; Region: FtsX; pfam02687 760192003328 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192003329 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192003330 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 760192003331 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 760192003332 proposed catalytic triad [active] 760192003333 active site nucleophile [active] 760192003334 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 760192003335 Galactose oxidase, central domain; Region: Kelch_3; cl02701 760192003336 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 760192003337 Kelch motif; Region: Kelch_1; pfam01344 760192003338 Caspase domain; Region: Peptidase_C14; pfam00656 760192003339 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192003340 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192003341 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192003342 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192003343 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192003344 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 760192003345 Domain of unknown function DUF20; Region: UPF0118; pfam01594 760192003346 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 760192003347 classical (c) SDRs; Region: SDR_c; cd05233 760192003348 NAD(P) binding site [chemical binding]; other site 760192003349 active site 760192003350 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 760192003351 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 760192003352 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 760192003353 coregulator recognition site; other site 760192003354 ligand binding site [chemical binding]; other site 760192003355 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192003356 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 760192003357 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760192003358 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 760192003359 cyclase homology domain; Region: CHD; cd07302 760192003360 nucleotidyl binding site; other site 760192003361 metal binding site [ion binding]; metal-binding site 760192003362 dimer interface [polypeptide binding]; other site 760192003363 XisI protein; Region: XisI; pfam08869 760192003364 XisH protein; Region: XisH; pfam08814 760192003365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 760192003366 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 760192003367 substrate binding site [chemical binding]; other site 760192003368 active site 760192003369 Domain of unknown function (DUF303); Region: DUF303; pfam03629 760192003370 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760192003371 Domain of unknown function (DUF303); Region: DUF303; pfam03629 760192003372 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 760192003373 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192003374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192003375 Walker A motif; other site 760192003376 ATP binding site [chemical binding]; other site 760192003377 Walker B motif; other site 760192003378 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; cl00815 760192003379 arginine finger; other site 760192003380 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 760192003381 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 760192003382 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 760192003383 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192003384 DNA binding residues [nucleotide binding] 760192003385 dimerization interface [polypeptide binding]; other site 760192003386 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 760192003387 Aspartase; Region: Aspartase; cd01357 760192003388 active sites [active] 760192003389 tetramer interface [polypeptide binding]; other site 760192003390 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 760192003391 TrkA-N domain; Region: TrkA_N; pfam02254 760192003392 TrkA-C domain; Region: TrkA_C; pfam02080 760192003393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192003394 dimer interface [polypeptide binding]; other site 760192003395 phosphorylation site [posttranslational modification] 760192003396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192003397 ATP binding site [chemical binding]; other site 760192003398 Mg2+ binding site [ion binding]; other site 760192003399 G-X-G motif; other site 760192003400 Response regulator receiver domain; Region: Response_reg; pfam00072 760192003401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003402 active site 760192003403 phosphorylation site [posttranslational modification] 760192003404 intermolecular recognition site; other site 760192003405 dimerization interface [polypeptide binding]; other site 760192003406 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 760192003407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192003408 putative substrate translocation pore; other site 760192003409 Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248 760192003410 active site 760192003411 S2 subsite; other site 760192003412 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 760192003413 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192003414 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760192003415 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760192003416 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192003417 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003418 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192003419 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192003420 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 760192003421 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192003422 Family description; Region: VCBS; pfam13517 760192003423 Family description; Region: VCBS; pfam13517 760192003424 Family description; Region: VCBS; pfam13517 760192003425 Family description; Region: VCBS; pfam13517 760192003426 Family description; Region: VCBS; pfam13517 760192003427 Family description; Region: VCBS; pfam13517 760192003428 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 760192003429 Family description; Region: VCBS; pfam13517 760192003430 Family description; Region: VCBS; pfam13517 760192003431 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192003432 active site 760192003433 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192003434 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 760192003435 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 760192003436 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 760192003437 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 760192003438 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192003439 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192003440 Fn3 associated; Region: Fn3_assoc; pfam13287 760192003441 methionine sulfoxide reductase B; Provisional; Region: PRK00222 760192003442 SelR domain; Region: SelR; pfam01641 760192003443 Surface antigen; Region: Bac_surface_Ag; pfam01103 760192003444 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192003445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192003446 Walker A/P-loop; other site 760192003447 ATP binding site [chemical binding]; other site 760192003448 Q-loop/lid; other site 760192003449 ABC transporter signature motif; other site 760192003450 Walker B; other site 760192003451 D-loop; other site 760192003452 H-loop/switch region; other site 760192003453 DNA helicase, putative; Region: TIGR00376 760192003454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192003455 ATP binding site [chemical binding]; other site 760192003456 AAA domain; Region: AAA_12; pfam13087 760192003457 gliding motility associated protien GldN; Region: GldN; TIGR03523 760192003458 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 760192003459 GldM N-terminal domain; Region: GldM_N; pfam12081 760192003460 GldM C-terminal domain; Region: GldM_C; pfam12080 760192003461 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 760192003462 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 760192003463 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 760192003464 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 760192003465 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192003466 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 760192003467 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 760192003468 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 760192003469 catalytic residues [active] 760192003470 FeoA domain; Region: FeoA; pfam04023 760192003471 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 760192003472 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 760192003473 G1 box; other site 760192003474 GTP/Mg2+ binding site [chemical binding]; other site 760192003475 Switch I region; other site 760192003476 G2 box; other site 760192003477 G3 box; other site 760192003478 Switch II region; other site 760192003479 G4 box; other site 760192003480 G5 box; other site 760192003481 Nucleoside recognition; Region: Gate; pfam07670 760192003482 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 760192003483 Nucleoside recognition; Region: Gate; pfam07670 760192003484 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 760192003485 Uncharacterized subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u3; cd12832 760192003486 oligomer interface [polypeptide binding]; other site 760192003487 metal binding site [ion binding]; metal-binding site 760192003488 putative Cl binding site [ion binding]; other site 760192003489 basic sphincter; other site 760192003490 hydrophobic gate; other site 760192003491 periplasmic entrance; other site 760192003492 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192003493 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192003494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003495 active site 760192003496 phosphorylation site [posttranslational modification] 760192003497 intermolecular recognition site; other site 760192003498 dimerization interface [polypeptide binding]; other site 760192003499 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192003500 DNA binding residues [nucleotide binding] 760192003501 dimerization interface [polypeptide binding]; other site 760192003502 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192003503 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192003504 Histidine kinase; Region: HisKA_3; pfam07730 760192003505 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 760192003506 ATP binding site [chemical binding]; other site 760192003507 Mg2+ binding site [ion binding]; other site 760192003508 G-X-G motif; other site 760192003509 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 760192003510 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 760192003511 active site 760192003512 PHP Thumb interface [polypeptide binding]; other site 760192003513 metal binding site [ion binding]; metal-binding site 760192003514 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 760192003515 generic binding surface I; other site 760192003516 generic binding surface II; other site 760192003517 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192003518 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192003519 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192003520 Phosphopantetheine attachment site; Region: PP-binding; cl09936 760192003521 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 760192003522 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 760192003523 active site 760192003524 zinc binding site [ion binding]; other site 760192003525 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 760192003526 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 760192003527 putative ADP-ribose binding site [chemical binding]; other site 760192003528 putative active site [active] 760192003529 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 760192003530 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 760192003531 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 760192003532 N- and C-terminal domain interface [polypeptide binding]; other site 760192003533 active site 760192003534 catalytic site [active] 760192003535 metal binding site [ion binding]; metal-binding site 760192003536 carbohydrate binding site [chemical binding]; other site 760192003537 ATP binding site [chemical binding]; other site 760192003538 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760192003539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192003540 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192003541 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003542 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192003543 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 760192003544 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192003545 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 760192003546 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 760192003547 N- and C-terminal domain interface [polypeptide binding]; other site 760192003548 active site 760192003549 catalytic site [active] 760192003550 metal binding site [ion binding]; metal-binding site 760192003551 carbohydrate binding site [chemical binding]; other site 760192003552 ATP binding site [chemical binding]; other site 760192003553 Response regulator receiver domain; Region: Response_reg; pfam00072 760192003554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003555 active site 760192003556 phosphorylation site [posttranslational modification] 760192003557 intermolecular recognition site; other site 760192003558 dimerization interface [polypeptide binding]; other site 760192003559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192003560 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192003561 Walker A motif; other site 760192003562 ATP binding site [chemical binding]; other site 760192003563 Walker B motif; other site 760192003564 arginine finger; other site 760192003565 Transposase IS200 like; Region: Y1_Tnp; pfam01797 760192003566 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 760192003567 HsdM N-terminal domain; Region: HsdM_N; pfam12161 760192003568 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760192003569 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760192003570 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 760192003571 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 760192003572 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 760192003573 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 760192003574 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192003575 ATP binding site [chemical binding]; other site 760192003576 putative Mg++ binding site [ion binding]; other site 760192003577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 760192003578 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 760192003579 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 760192003580 metal binding site [ion binding]; metal-binding site 760192003581 dimer interface [polypeptide binding]; other site 760192003582 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 760192003583 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192003584 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 760192003585 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192003586 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192003587 Histidine kinase; Region: His_kinase; pfam06580 760192003588 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192003589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003590 active site 760192003591 phosphorylation site [posttranslational modification] 760192003592 intermolecular recognition site; other site 760192003593 dimerization interface [polypeptide binding]; other site 760192003594 LytTr DNA-binding domain; Region: LytTR; smart00850 760192003595 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 760192003596 Protein of unknown function, DUF547; Region: DUF547; pfam04784 760192003597 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 760192003598 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 760192003599 Probable Catalytic site; other site 760192003600 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 760192003601 Zn binding site [ion binding]; other site 760192003602 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 760192003603 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 760192003604 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 760192003605 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192003606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003607 active site 760192003608 phosphorylation site [posttranslational modification] 760192003609 intermolecular recognition site; other site 760192003610 dimerization interface [polypeptide binding]; other site 760192003611 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192003612 DNA binding residues [nucleotide binding] 760192003613 dimerization interface [polypeptide binding]; other site 760192003614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192003615 Histidine kinase; Region: HisKA_3; pfam07730 760192003616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192003617 ATP binding site [chemical binding]; other site 760192003618 Mg2+ binding site [ion binding]; other site 760192003619 G-X-G motif; other site 760192003620 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 760192003621 OstA-like protein; Region: OstA_2; pfam13100 760192003622 OstA-like protein; Region: OstA; cl00844 760192003623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192003624 Tetratricopeptide repeat; Region: TPR_16; pfam13432 760192003625 TPR motif; other site 760192003626 Bacterial SH3 domain homologues; Region: SH3b; smart00287 760192003627 TIGR02646 family protein; Region: TIGR02646 760192003628 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 760192003629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192003630 AAA domain; Region: AAA_21; pfam13304 760192003631 Walker A/P-loop; other site 760192003632 ATP binding site [chemical binding]; other site 760192003633 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 760192003634 Uncharacterized conserved protein [Function unknown]; Region: COG3743 760192003635 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 760192003636 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 760192003637 catalytic motif [active] 760192003638 Catalytic residue [active] 760192003639 Aspartyl protease; Region: Asp_protease_2; pfam13650 760192003640 inhibitor binding site; inhibition site 760192003641 catalytic motif [active] 760192003642 Catalytic residue [active] 760192003643 Active site flap [active] 760192003644 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760192003645 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192003646 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003647 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192003648 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192003649 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192003650 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192003651 SusD family; Region: SusD; pfam07980 760192003652 Family description; Region: VCBS; pfam13517 760192003653 Family description; Region: VCBS; pfam13517 760192003654 Family description; Region: VCBS; pfam13517 760192003655 Family description; Region: VCBS; pfam13517 760192003656 Family description; Region: VCBS; pfam13517 760192003657 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 760192003658 Family description; Region: VCBS; pfam13517 760192003659 Family description; Region: VCBS; pfam13517 760192003660 Family description; Region: VCBS; pfam13517 760192003661 Family description; Region: VCBS; pfam13517 760192003662 Family description; Region: VCBS; pfam13517 760192003663 Family description; Region: VCBS; pfam13517 760192003664 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 760192003665 Family description; Region: VCBS; pfam13517 760192003666 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192003667 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192003668 active site 760192003669 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192003670 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192003671 Family description; Region: VCBS; pfam13517 760192003672 Family description; Region: VCBS; pfam13517 760192003673 Family description; Region: VCBS; pfam13517 760192003674 Family description; Region: VCBS; pfam13517 760192003675 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 760192003676 Family description; Region: VCBS; pfam13517 760192003677 Family description; Region: VCBS; pfam13517 760192003678 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 760192003679 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003680 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192003681 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192003682 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 760192003683 oligomeric interface; other site 760192003684 putative active site [active] 760192003685 homodimer interface [polypeptide binding]; other site 760192003686 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003687 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192003688 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192003689 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192003690 Clp protease; Region: CLP_protease; pfam00574 760192003691 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 760192003692 oligomer interface [polypeptide binding]; other site 760192003693 active site residues [active] 760192003694 Methane oxygenase PmoA; Region: PmoA; pfam14100 760192003695 Trehalose utilisation; Region: ThuA; pfam06283 760192003696 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192003697 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192003698 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192003699 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192003700 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 760192003701 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 760192003702 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 760192003703 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 760192003704 active site 760192003705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 760192003706 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 760192003707 DoxX-like family; Region: DoxX_3; pfam13781 760192003708 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192003709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192003710 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760192003711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192003712 NAD(P) binding site [chemical binding]; other site 760192003713 active site 760192003714 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760192003715 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760192003716 hypothetical protein; Provisional; Region: PRK07758 760192003717 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 760192003718 Methyltransferase domain; Region: Methyltransf_23; pfam13489 760192003719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192003720 S-adenosylmethionine binding site [chemical binding]; other site 760192003721 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 760192003722 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 760192003723 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192003724 putative active site [active] 760192003725 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192003726 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192003727 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192003728 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192003729 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003730 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192003731 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192003732 FecR protein; Region: FecR; pfam04773 760192003733 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192003734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192003735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192003736 DNA binding residues [nucleotide binding] 760192003737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192003738 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192003739 Walker A motif; other site 760192003740 ATP binding site [chemical binding]; other site 760192003741 Walker B motif; other site 760192003742 arginine finger; other site 760192003743 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 760192003744 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 760192003745 active site 760192003746 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192003747 pyruvate carboxylase; Reviewed; Region: PRK12999 760192003748 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 760192003749 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192003750 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 760192003751 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 760192003752 active site 760192003753 catalytic residues [active] 760192003754 metal binding site [ion binding]; metal-binding site 760192003755 homodimer binding site [polypeptide binding]; other site 760192003756 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 760192003757 carboxyltransferase (CT) interaction site; other site 760192003758 biotinylation site [posttranslational modification]; other site 760192003759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 760192003760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192003761 Coenzyme A binding pocket [chemical binding]; other site 760192003762 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 760192003763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192003764 Coenzyme A binding pocket [chemical binding]; other site 760192003765 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 760192003766 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760192003767 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 760192003768 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 760192003769 putative active site [active] 760192003770 substrate binding site [chemical binding]; other site 760192003771 putative cosubstrate binding site; other site 760192003772 catalytic site [active] 760192003773 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 760192003774 substrate binding site [chemical binding]; other site 760192003775 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760192003776 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 760192003777 Walker A/P-loop; other site 760192003778 ATP binding site [chemical binding]; other site 760192003779 Q-loop/lid; other site 760192003780 ABC transporter signature motif; other site 760192003781 Walker B; other site 760192003782 D-loop; other site 760192003783 H-loop/switch region; other site 760192003784 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 760192003785 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 760192003786 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 760192003787 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 760192003788 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 760192003789 Zn binding site [ion binding]; other site 760192003790 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 760192003791 TPR repeat; Region: TPR_11; pfam13414 760192003792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192003793 binding surface 760192003794 TPR motif; other site 760192003795 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 760192003796 CHRD domain; Region: CHRD; pfam07452 760192003797 CHRD domain; Region: CHRD; pfam07452 760192003798 CHRD domain; Region: CHRD; pfam07452 760192003799 CHRD domain; Region: CHRD; pfam07452 760192003800 CHRD domain; Region: CHRD; pfam07452 760192003801 CHRD domain; Region: CHRD; pfam07452 760192003802 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192003803 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192003804 AAA ATPase domain; Region: AAA_16; pfam13191 760192003805 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 760192003806 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 760192003807 active site 760192003808 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 760192003809 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192003810 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 760192003811 inhibitor-cofactor binding pocket; inhibition site 760192003812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192003813 catalytic residue [active] 760192003814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192003815 Coenzyme A binding pocket [chemical binding]; other site 760192003816 succinic semialdehyde dehydrogenase; Region: PLN02278 760192003817 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 760192003818 tetramerization interface [polypeptide binding]; other site 760192003819 NAD(P) binding site [chemical binding]; other site 760192003820 catalytic residues [active] 760192003821 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 760192003822 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192003823 inhibitor-cofactor binding pocket; inhibition site 760192003824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192003825 catalytic residue [active] 760192003826 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 760192003827 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 760192003828 NAD(P) binding site [chemical binding]; other site 760192003829 catalytic residues [active] 760192003830 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 760192003831 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192003832 dimerization interface [polypeptide binding]; other site 760192003833 putative DNA binding site [nucleotide binding]; other site 760192003834 putative Zn2+ binding site [ion binding]; other site 760192003835 AsnC family; Region: AsnC_trans_reg; pfam01037 760192003836 fructuronate transporter; Provisional; Region: PRK10034; cl15264 760192003837 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 760192003838 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 760192003839 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 760192003840 GTP-binding protein LepA; Provisional; Region: PRK05433 760192003841 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 760192003842 G1 box; other site 760192003843 putative GEF interaction site [polypeptide binding]; other site 760192003844 GTP/Mg2+ binding site [chemical binding]; other site 760192003845 Switch I region; other site 760192003846 G2 box; other site 760192003847 G3 box; other site 760192003848 Switch II region; other site 760192003849 G4 box; other site 760192003850 G5 box; other site 760192003851 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 760192003852 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 760192003853 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 760192003854 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192003855 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 760192003856 putative active site [active] 760192003857 putative metal binding site [ion binding]; other site 760192003858 regulatory protein CsrD; Provisional; Region: PRK11059 760192003859 Cupin domain; Region: Cupin_2; cl17218 760192003860 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760192003861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192003862 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 760192003863 hydroxyglutarate oxidase; Provisional; Region: PRK11728 760192003864 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 760192003865 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 760192003866 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192003867 motif II; other site 760192003868 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 760192003869 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760192003870 active site 760192003871 metal binding site [ion binding]; metal-binding site 760192003872 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 760192003873 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192003874 Asp-box motif; other site 760192003875 BNR repeat-like domain; Region: BNR_2; pfam13088 760192003876 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 760192003877 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 760192003878 nudix motif; other site 760192003879 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 760192003880 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 760192003881 dimer interface [polypeptide binding]; other site 760192003882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192003883 catalytic residue [active] 760192003884 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 760192003885 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 760192003886 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192003887 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192003888 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 760192003889 Domain of unknown function DUF20; Region: UPF0118; pfam01594 760192003890 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 760192003891 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192003892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003893 active site 760192003894 phosphorylation site [posttranslational modification] 760192003895 intermolecular recognition site; other site 760192003896 dimerization interface [polypeptide binding]; other site 760192003897 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 760192003898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192003899 putative active site [active] 760192003900 heme pocket [chemical binding]; other site 760192003901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192003902 dimer interface [polypeptide binding]; other site 760192003903 phosphorylation site [posttranslational modification] 760192003904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192003905 ATP binding site [chemical binding]; other site 760192003906 G-X-G motif; other site 760192003907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192003908 dimer interface [polypeptide binding]; other site 760192003909 phosphorylation site [posttranslational modification] 760192003910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192003911 ATP binding site [chemical binding]; other site 760192003912 Mg2+ binding site [ion binding]; other site 760192003913 G-X-G motif; other site 760192003914 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 760192003915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003916 active site 760192003917 phosphorylation site [posttranslational modification] 760192003918 intermolecular recognition site; other site 760192003919 dimerization interface [polypeptide binding]; other site 760192003920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192003921 Walker A motif; other site 760192003922 ATP binding site [chemical binding]; other site 760192003923 Walker B motif; other site 760192003924 arginine finger; other site 760192003925 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760192003926 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 760192003927 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 760192003928 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 760192003929 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 760192003930 CHASE3 domain; Region: CHASE3; pfam05227 760192003931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192003932 ATP binding site [chemical binding]; other site 760192003933 Mg2+ binding site [ion binding]; other site 760192003934 G-X-G motif; other site 760192003935 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192003936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003937 active site 760192003938 phosphorylation site [posttranslational modification] 760192003939 intermolecular recognition site; other site 760192003940 Response regulator receiver domain; Region: Response_reg; pfam00072 760192003941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192003942 active site 760192003943 phosphorylation site [posttranslational modification] 760192003944 intermolecular recognition site; other site 760192003945 dimerization interface [polypeptide binding]; other site 760192003946 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 760192003947 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192003948 AAA ATPase domain; Region: AAA_16; pfam13191 760192003949 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 760192003950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192003951 binding surface 760192003952 TPR motif; other site 760192003953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192003954 binding surface 760192003955 TPR motif; other site 760192003956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192003957 binding surface 760192003958 TPR motif; other site 760192003959 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 760192003960 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 760192003961 Na binding site [ion binding]; other site 760192003962 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 760192003963 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 760192003964 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 760192003965 active site 760192003966 NTP binding site [chemical binding]; other site 760192003967 metal binding triad [ion binding]; metal-binding site 760192003968 antibiotic binding site [chemical binding]; other site 760192003969 pfkB-type carbohydrate kinase family protein; Region: PLN02630 760192003970 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 760192003971 homodimer interface [polypeptide binding]; other site 760192003972 homotetramer interface [polypeptide binding]; other site 760192003973 active site pocket [active] 760192003974 cleavage site 760192003975 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 760192003976 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192003977 N-terminal plug; other site 760192003978 ligand-binding site [chemical binding]; other site 760192003979 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 760192003980 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 760192003981 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760192003982 HipA N-terminal domain; Region: Couple_hipA; cl11853 760192003983 HipA-like N-terminal domain; Region: HipA_N; pfam07805 760192003984 HipA-like C-terminal domain; Region: HipA_C; pfam07804 760192003985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192003986 non-specific DNA binding site [nucleotide binding]; other site 760192003987 salt bridge; other site 760192003988 sequence-specific DNA binding site [nucleotide binding]; other site 760192003989 intracellular protease, PfpI family; Region: PfpI; TIGR01382 760192003990 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 760192003991 conserved cys residue [active] 760192003992 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 760192003993 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 760192003994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192003995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192003996 dimer interface [polypeptide binding]; other site 760192003997 phosphorylation site [posttranslational modification] 760192003998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192003999 ATP binding site [chemical binding]; other site 760192004000 Mg2+ binding site [ion binding]; other site 760192004001 G-X-G motif; other site 760192004002 Response regulator receiver domain; Region: Response_reg; pfam00072 760192004003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192004004 active site 760192004005 phosphorylation site [posttranslational modification] 760192004006 intermolecular recognition site; other site 760192004007 dimerization interface [polypeptide binding]; other site 760192004008 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 760192004009 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192004010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192004011 active site 760192004012 phosphorylation site [posttranslational modification] 760192004013 intermolecular recognition site; other site 760192004014 dimerization interface [polypeptide binding]; other site 760192004015 LytTr DNA-binding domain; Region: LytTR; smart00850 760192004016 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004017 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 760192004018 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192004019 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192004020 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192004021 EthD domain; Region: EthD; cl17553 760192004022 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 760192004023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 760192004024 SPFH domain / Band 7 family; Region: Band_7; pfam01145 760192004025 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 760192004026 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 760192004027 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 760192004028 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192004029 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 760192004030 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 760192004031 Caspase domain; Region: Peptidase_C14; pfam00656 760192004032 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 760192004033 active site 760192004034 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 760192004035 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192004036 catalytic loop [active] 760192004037 iron binding site [ion binding]; other site 760192004038 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 760192004039 L-aspartate oxidase; Provisional; Region: PRK06175 760192004040 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 760192004041 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 760192004042 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 760192004043 putative Iron-sulfur protein interface [polypeptide binding]; other site 760192004044 proximal heme binding site [chemical binding]; other site 760192004045 distal heme binding site [chemical binding]; other site 760192004046 putative dimer interface [polypeptide binding]; other site 760192004047 ribonuclease R; Region: RNase_R; TIGR02063 760192004048 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 760192004049 RNB domain; Region: RNB; pfam00773 760192004050 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 760192004051 RNA binding site [nucleotide binding]; other site 760192004052 AAA domain; Region: AAA_21; pfam13304 760192004053 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 760192004054 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 760192004055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192004056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192004057 DNA binding residues [nucleotide binding] 760192004058 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 760192004059 dimer interface [polypeptide binding]; other site 760192004060 ADP-ribose binding site [chemical binding]; other site 760192004061 active site 760192004062 nudix motif; other site 760192004063 metal binding site [ion binding]; metal-binding site 760192004064 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192004065 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192004066 active site 760192004067 catalytic tetrad [active] 760192004068 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760192004069 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192004070 active site 760192004071 metal binding site [ion binding]; metal-binding site 760192004072 PQQ-like domain; Region: PQQ_2; pfam13360 760192004073 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 760192004074 Trp docking motif [polypeptide binding]; other site 760192004075 active site 760192004076 FOG: WD40-like repeat [Function unknown]; Region: COG1520 760192004077 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 760192004078 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 760192004079 Caspase domain; Region: Peptidase_C14; pfam00656 760192004080 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 760192004081 active site 760192004082 nucleophile elbow; other site 760192004083 CHAT domain; Region: CHAT; cl17868 760192004084 AAA ATPase domain; Region: AAA_16; pfam13191 760192004085 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192004086 Walker A motif; other site 760192004087 ATP binding site [chemical binding]; other site 760192004088 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192004089 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192004090 structural tetrad; other site 760192004091 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192004092 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192004093 structural tetrad; other site 760192004094 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192004095 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 760192004096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192004097 TPR motif; other site 760192004098 binding surface 760192004099 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192004100 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192004101 ligand binding site [chemical binding]; other site 760192004102 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 760192004103 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192004104 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 760192004105 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 760192004106 putative active site [active] 760192004107 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 760192004108 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 760192004109 GH3 auxin-responsive promoter; Region: GH3; pfam03321 760192004110 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 760192004111 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760192004112 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760192004113 putative transposase OrfB; Reviewed; Region: PHA02517 760192004114 Integrase core domain; Region: rve; pfam00665 760192004115 Integrase core domain; Region: rve_3; pfam13683 760192004116 C-terminal peptidase (prc); Region: prc; TIGR00225 760192004117 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760192004118 protein binding site [polypeptide binding]; other site 760192004119 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 760192004120 Catalytic dyad [active] 760192004121 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 760192004122 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 760192004123 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 760192004124 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 760192004125 active site 760192004126 dimer interfaces [polypeptide binding]; other site 760192004127 catalytic residues [active] 760192004128 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 760192004129 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 760192004130 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760192004131 putative NAD(P) binding site [chemical binding]; other site 760192004132 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 760192004133 Right handed beta helix region; Region: Beta_helix; pfam13229 760192004134 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 760192004135 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 760192004136 Ligand binding site; other site 760192004137 Putative Catalytic site; other site 760192004138 DXD motif; other site 760192004139 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 760192004140 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760192004141 DXD motif; other site 760192004142 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 760192004143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192004144 TPR motif; other site 760192004145 binding surface 760192004146 TPR repeat; Region: TPR_11; pfam13414 760192004147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192004148 TPR motif; other site 760192004149 binding surface 760192004150 TPR repeat; Region: TPR_11; pfam13414 760192004151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192004152 binding surface 760192004153 TPR motif; other site 760192004154 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 760192004155 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 760192004156 Transglycosylase; Region: Transgly; pfam00912 760192004157 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 760192004158 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 760192004159 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 760192004160 active site 760192004161 catalytic site [active] 760192004162 substrate binding site [chemical binding]; other site 760192004163 Domain of unknown function (DUF1875); Region: DUF1875; pfam08961 760192004164 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 760192004165 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 760192004166 Imelysin; Region: Peptidase_M75; pfam09375 760192004167 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 760192004168 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192004169 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192004170 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 760192004171 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760192004172 catalytic core [active] 760192004173 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 760192004174 heme-binding site [chemical binding]; other site 760192004175 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192004176 putative active site [active] 760192004177 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 760192004178 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 760192004179 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 760192004180 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192004181 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 760192004182 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192004183 N-terminal plug; other site 760192004184 ligand-binding site [chemical binding]; other site 760192004185 radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115 760192004186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192004187 FeS/SAM binding site; other site 760192004188 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 760192004189 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 760192004190 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 760192004191 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 760192004192 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 760192004193 lycopene cyclase; Region: lycopene_cycl; TIGR01789 760192004194 Fasciclin domain; Region: Fasciclin; pfam02469 760192004195 Fasciclin domain; Region: Fasciclin; pfam02469 760192004196 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 760192004197 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 760192004198 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760192004199 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760192004200 Histidine kinase; Region: His_kinase; pfam06580 760192004201 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192004202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192004203 active site 760192004204 phosphorylation site [posttranslational modification] 760192004205 intermolecular recognition site; other site 760192004206 dimerization interface [polypeptide binding]; other site 760192004207 LytTr DNA-binding domain; Region: LytTR; smart00850 760192004208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192004209 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 760192004210 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192004211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 760192004212 ligand binding site [chemical binding]; other site 760192004213 flexible hinge region; other site 760192004214 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192004215 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 760192004216 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192004217 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 760192004218 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192004219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192004220 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 760192004221 Virulence protein [General function prediction only]; Region: COG3943 760192004222 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 760192004223 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192004224 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192004225 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192004226 structural tetrad; other site 760192004227 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192004228 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192004229 structural tetrad; other site 760192004230 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192004231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192004232 TPR motif; other site 760192004233 binding surface 760192004234 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 760192004235 GTP/Mg2+ binding site [chemical binding]; other site 760192004236 G5 box; other site 760192004237 G1 box; other site 760192004238 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 760192004239 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192004240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 760192004241 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 760192004242 Transposase; Region: HTH_Tnp_1; pfam01527 760192004243 putative transposase OrfB; Reviewed; Region: PHA02517 760192004244 HTH-like domain; Region: HTH_21; pfam13276 760192004245 Integrase core domain; Region: rve; pfam00665 760192004246 Integrase core domain; Region: rve_3; pfam13683 760192004247 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 760192004248 putative active site [active] 760192004249 putative NTP binding site [chemical binding]; other site 760192004250 putative nucleic acid binding site [nucleotide binding]; other site 760192004251 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192004252 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 760192004253 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 760192004254 Chromate transporter; Region: Chromate_transp; pfam02417 760192004255 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192004256 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 760192004257 substrate binding pocket [chemical binding]; other site 760192004258 CAAX protease self-immunity; Region: Abi; pfam02517 760192004259 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 760192004260 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 760192004261 dimerization interface [polypeptide binding]; other site 760192004262 DPS ferroxidase diiron center [ion binding]; other site 760192004263 ion pore; other site 760192004264 CAAX protease self-immunity; Region: Abi; pfam02517 760192004265 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 760192004266 FMN binding site [chemical binding]; other site 760192004267 dimer interface [polypeptide binding]; other site 760192004268 Acetokinase family; Region: Acetate_kinase; cl17229 760192004269 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 760192004270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760192004271 Soluble P-type ATPase [General function prediction only]; Region: COG4087 760192004272 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238 760192004273 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 760192004274 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 760192004275 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192004276 Outer membrane efflux protein; Region: OEP; pfam02321 760192004277 Outer membrane efflux protein; Region: OEP; pfam02321 760192004278 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 760192004279 Heavy-metal-associated domain; Region: HMA; pfam00403 760192004280 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 760192004281 metal-binding site [ion binding] 760192004282 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192004283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192004284 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192004285 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192004286 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192004287 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192004288 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192004289 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192004290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192004291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192004292 dimer interface [polypeptide binding]; other site 760192004293 phosphorylation site [posttranslational modification] 760192004294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192004295 ATP binding site [chemical binding]; other site 760192004296 G-X-G motif; other site 760192004297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192004298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192004299 active site 760192004300 phosphorylation site [posttranslational modification] 760192004301 intermolecular recognition site; other site 760192004302 dimerization interface [polypeptide binding]; other site 760192004303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192004304 DNA binding site [nucleotide binding] 760192004305 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 760192004306 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 760192004307 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 760192004308 dimer interface [polypeptide binding]; other site 760192004309 decamer (pentamer of dimers) interface [polypeptide binding]; other site 760192004310 catalytic triad [active] 760192004311 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 760192004312 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192004313 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192004314 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192004315 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192004316 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 760192004317 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192004318 Sulfatase; Region: Sulfatase; pfam00884 760192004319 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192004320 Sulfatase; Region: Sulfatase; pfam00884 760192004321 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192004322 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192004323 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192004324 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192004325 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192004326 Ligand Binding Site [chemical binding]; other site 760192004327 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 760192004328 HupF/HypC family; Region: HupF_HypC; pfam01455 760192004329 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 760192004330 G1 box; other site 760192004331 GTP/Mg2+ binding site [chemical binding]; other site 760192004332 G2 box; other site 760192004333 Switch I region; other site 760192004334 Switch II region; other site 760192004335 G4 box; other site 760192004336 G5 box; other site 760192004337 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 760192004338 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 760192004339 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 760192004340 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 760192004341 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 760192004342 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 760192004343 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 760192004344 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 760192004345 nickel binding site [ion binding]; other site 760192004346 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 760192004347 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192004348 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192004349 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192004350 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 760192004351 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 760192004352 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 760192004353 Ca2+ binding site [ion binding]; other site 760192004354 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 760192004355 Ca2+ binding site [ion binding]; other site 760192004356 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 760192004357 Ca2+ binding site [ion binding]; other site 760192004358 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 760192004359 Ca2+ binding site [ion binding]; other site 760192004360 Cadherin repeat-like domain; Region: CA_like; cl15786 760192004361 Ca2+ binding site [ion binding]; other site 760192004362 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 760192004363 Ca2+ binding site [ion binding]; other site 760192004364 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 760192004365 Ca2+ binding site [ion binding]; other site 760192004366 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192004367 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192004368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192004369 non-specific DNA binding site [nucleotide binding]; other site 760192004370 salt bridge; other site 760192004371 sequence-specific DNA binding site [nucleotide binding]; other site 760192004372 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 760192004373 active site 760192004374 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004375 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192004376 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 760192004377 catalytic residue [active] 760192004378 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 760192004379 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 760192004380 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192004381 N-terminal plug; other site 760192004382 ligand-binding site [chemical binding]; other site 760192004383 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192004384 active site 760192004385 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 760192004386 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 760192004387 substrate binding site [chemical binding]; other site 760192004388 hexamer interface [polypeptide binding]; other site 760192004389 metal binding site [ion binding]; metal-binding site 760192004390 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192004391 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192004392 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 760192004393 active site 760192004394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 760192004395 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 760192004396 active site 760192004397 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192004398 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192004399 ligand binding site [chemical binding]; other site 760192004400 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 760192004401 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 760192004402 HipA-like N-terminal domain; Region: HipA_N; pfam07805 760192004403 HipA-like C-terminal domain; Region: HipA_C; pfam07804 760192004404 HipA N-terminal domain; Region: Couple_hipA; cl11853 760192004405 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192004406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192004407 non-specific DNA binding site [nucleotide binding]; other site 760192004408 salt bridge; other site 760192004409 sequence-specific DNA binding site [nucleotide binding]; other site 760192004410 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192004411 AAA ATPase domain; Region: AAA_16; pfam13191 760192004412 FAD binding domain; Region: FAD_binding_4; pfam01565 760192004413 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 760192004414 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 760192004415 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 760192004416 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 760192004417 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 760192004418 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 760192004419 Predicted transcriptional regulator [Transcription]; Region: COG2932 760192004420 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760192004421 Catalytic site [active] 760192004422 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 760192004423 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 760192004424 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 760192004425 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 760192004426 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 760192004427 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 760192004428 PA/protease or protease-like domain interface [polypeptide binding]; other site 760192004429 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 760192004430 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 760192004431 Zn binding site [ion binding]; other site 760192004432 Domain of unknown function DUF11; Region: DUF11; cl17728 760192004433 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 760192004434 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004435 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 760192004436 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192004437 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 760192004438 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 760192004439 Cu(I) binding site [ion binding]; other site 760192004440 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 760192004441 Part of AAA domain; Region: AAA_19; pfam13245 760192004442 Family description; Region: UvrD_C_2; pfam13538 760192004443 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 760192004444 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 760192004445 putative hydrophobic ligand binding site [chemical binding]; other site 760192004446 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 760192004447 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 760192004448 DNA binding site [nucleotide binding] 760192004449 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760192004450 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760192004451 Walker A/P-loop; other site 760192004452 ATP binding site [chemical binding]; other site 760192004453 Q-loop/lid; other site 760192004454 ABC transporter signature motif; other site 760192004455 Walker B; other site 760192004456 D-loop; other site 760192004457 H-loop/switch region; other site 760192004458 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 760192004459 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 760192004460 homotetramer interface [polypeptide binding]; other site 760192004461 ligand binding site [chemical binding]; other site 760192004462 catalytic site [active] 760192004463 NAD binding site [chemical binding]; other site 760192004464 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192004465 putative active site [active] 760192004466 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 760192004467 active site 760192004468 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 760192004469 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 760192004470 Low molecular weight phosphatase family; Region: LMWPc; cd00115 760192004471 active site 760192004472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 760192004473 active site 760192004474 motif I; other site 760192004475 motif II; other site 760192004476 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 760192004477 Peptidase family M23; Region: Peptidase_M23; pfam01551 760192004478 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 760192004479 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 760192004480 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 760192004481 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 760192004482 active site 760192004483 catalytic residues [active] 760192004484 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192004485 active site 760192004486 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 760192004487 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 760192004488 putative catalytic cysteine [active] 760192004489 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 760192004490 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004491 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 760192004492 putative active site [active] 760192004493 Predicted acyl esterases [General function prediction only]; Region: COG2936 760192004494 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 760192004495 lipoyl synthase; Provisional; Region: PRK05481 760192004496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192004497 FeS/SAM binding site; other site 760192004498 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 760192004499 putative active site [active] 760192004500 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 760192004501 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 760192004502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192004503 short chain dehydrogenase; Provisional; Region: PRK12828 760192004504 NAD(P) binding site [chemical binding]; other site 760192004505 active site 760192004506 alpha-glucosidase; Provisional; Region: PRK10137 760192004507 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 760192004508 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 760192004509 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760192004510 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192004511 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192004512 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 760192004513 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192004514 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 760192004515 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 760192004516 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 760192004517 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 760192004518 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 760192004519 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 760192004520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192004521 non-specific DNA binding site [nucleotide binding]; other site 760192004522 salt bridge; other site 760192004523 sequence-specific DNA binding site [nucleotide binding]; other site 760192004524 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 760192004525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 760192004526 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 760192004527 mce related protein; Region: MCE; pfam02470 760192004528 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 760192004529 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 760192004530 Walker A/P-loop; other site 760192004531 ATP binding site [chemical binding]; other site 760192004532 Q-loop/lid; other site 760192004533 ABC transporter signature motif; other site 760192004534 Walker B; other site 760192004535 D-loop; other site 760192004536 H-loop/switch region; other site 760192004537 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 760192004538 Permease; Region: Permease; pfam02405 760192004539 FAD binding domain; Region: FAD_binding_4; pfam01565 760192004540 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 760192004541 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 760192004542 Homeodomain-like domain; Region: HTH_23; pfam13384 760192004543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 760192004544 Winged helix-turn helix; Region: HTH_33; pfam13592 760192004545 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192004546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 760192004547 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 760192004548 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192004549 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192004550 LytTr DNA-binding domain; Region: LytTR; smart00850 760192004551 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192004552 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192004553 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 760192004554 Protein export membrane protein; Region: SecD_SecF; cl14618 760192004555 Outer membrane efflux protein; Region: OEP; pfam02321 760192004556 Outer membrane efflux protein; Region: OEP; pfam02321 760192004557 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 760192004558 putative ligand binding site [chemical binding]; other site 760192004559 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 760192004560 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192004561 putative active site [active] 760192004562 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 760192004563 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 760192004564 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 760192004565 acyl-activating enzyme (AAE) consensus motif; other site 760192004566 acyl-activating enzyme (AAE) consensus motif; other site 760192004567 putative AMP binding site [chemical binding]; other site 760192004568 putative active site [active] 760192004569 putative CoA binding site [chemical binding]; other site 760192004570 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 760192004571 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 760192004572 dimer interface [polypeptide binding]; other site 760192004573 active site 760192004574 CoA binding pocket [chemical binding]; other site 760192004575 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192004576 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192004577 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192004578 N-terminal plug; other site 760192004579 ligand-binding site [chemical binding]; other site 760192004580 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760192004581 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760192004582 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 760192004583 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 760192004584 NAD(P) binding site [chemical binding]; other site 760192004585 homotetramer interface [polypeptide binding]; other site 760192004586 homodimer interface [polypeptide binding]; other site 760192004587 active site 760192004588 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 760192004589 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192004590 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192004591 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192004592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192004593 Walker A/P-loop; other site 760192004594 ATP binding site [chemical binding]; other site 760192004595 AAA domain; Region: AAA_21; pfam13304 760192004596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 760192004597 Walker B; other site 760192004598 D-loop; other site 760192004599 H-loop/switch region; other site 760192004600 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 760192004601 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760192004602 active site 760192004603 HIGH motif; other site 760192004604 nucleotide binding site [chemical binding]; other site 760192004605 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 760192004606 active site 760192004607 KMSKS motif; other site 760192004608 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 760192004609 tRNA binding surface [nucleotide binding]; other site 760192004610 anticodon binding site; other site 760192004611 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 760192004612 AAA domain; Region: AAA_14; pfam13173 760192004613 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 760192004614 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760192004615 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760192004616 P-loop; other site 760192004617 Magnesium ion binding site [ion binding]; other site 760192004618 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 760192004619 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 760192004620 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 760192004621 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 760192004622 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 760192004623 high affinity sulphate transporter 1; Region: sulP; TIGR00815 760192004624 Sulfate transporter family; Region: Sulfate_transp; pfam00916 760192004625 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 760192004626 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 760192004627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760192004628 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192004629 active site residue [active] 760192004630 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192004631 active site residue [active] 760192004632 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 760192004633 Sulphur transport; Region: Sulf_transp; pfam04143 760192004634 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192004635 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192004636 ligand binding site [chemical binding]; other site 760192004637 flexible hinge region; other site 760192004638 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192004639 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192004640 protein binding site [polypeptide binding]; other site 760192004641 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192004642 active site residue [active] 760192004643 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 760192004644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192004645 putative DNA binding site [nucleotide binding]; other site 760192004646 putative Zn2+ binding site [ion binding]; other site 760192004647 AsnC family; Region: AsnC_trans_reg; pfam01037 760192004648 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 760192004649 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 760192004650 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 760192004651 putative active site [active] 760192004652 Zn binding site [ion binding]; other site 760192004653 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 760192004654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192004655 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004656 GSCFA family; Region: GSCFA; pfam08885 760192004657 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 760192004658 trimer interface [polypeptide binding]; other site 760192004659 dimer interface [polypeptide binding]; other site 760192004660 putative active site [active] 760192004661 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 760192004662 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 760192004663 putative molybdopterin cofactor binding site [chemical binding]; other site 760192004664 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 760192004665 putative molybdopterin cofactor binding site; other site 760192004666 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 760192004667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192004668 FeS/SAM binding site; other site 760192004669 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 760192004670 Pectate lyase; Region: Pec_lyase_C; cl01593 760192004671 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004672 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 760192004673 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 760192004674 putative NAD(P) binding site [chemical binding]; other site 760192004675 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 760192004676 oligomeric interface; other site 760192004677 putative active site [active] 760192004678 homodimer interface [polypeptide binding]; other site 760192004679 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 760192004680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192004681 S-adenosylmethionine binding site [chemical binding]; other site 760192004682 cell surface protein SprA; Region: surface_SprA; TIGR04189 760192004683 Motility related/secretion protein; Region: SprA_N; pfam14349 760192004684 Motility related/secretion protein; Region: SprA_N; pfam14349 760192004685 Motility related/secretion protein; Region: SprA_N; pfam14349 760192004686 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 760192004687 RuvA N terminal domain; Region: RuvA_N; pfam01330 760192004688 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 760192004689 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 760192004690 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 760192004691 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 760192004692 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 760192004693 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 760192004694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192004695 putative substrate translocation pore; other site 760192004696 POT family; Region: PTR2; cl17359 760192004697 peptide chain release factor 1; Validated; Region: prfA; PRK00591 760192004698 PCRF domain; Region: PCRF; pfam03462 760192004699 RF-1 domain; Region: RF-1; pfam00472 760192004700 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 760192004701 Glycoprotease family; Region: Peptidase_M22; pfam00814 760192004702 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192004703 dimerization interface [polypeptide binding]; other site 760192004704 putative DNA binding site [nucleotide binding]; other site 760192004705 putative Zn2+ binding site [ion binding]; other site 760192004706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192004707 dimerization interface [polypeptide binding]; other site 760192004708 putative DNA binding site [nucleotide binding]; other site 760192004709 putative Zn2+ binding site [ion binding]; other site 760192004710 GH3 auxin-responsive promoter; Region: GH3; pfam03321 760192004711 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 760192004712 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 760192004713 putative dimer interface [polypeptide binding]; other site 760192004714 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 760192004715 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 760192004716 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 760192004717 oxalacetate binding site [chemical binding]; other site 760192004718 citrylCoA binding site [chemical binding]; other site 760192004719 coenzyme A binding site [chemical binding]; other site 760192004720 catalytic triad [active] 760192004721 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 760192004722 lipoyl attachment site [posttranslational modification]; other site 760192004723 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 760192004724 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 760192004725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192004726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192004727 DNA binding residues [nucleotide binding] 760192004728 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760192004729 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760192004730 active site 760192004731 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 760192004732 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 760192004733 putative acyl-acceptor binding pocket; other site 760192004734 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 760192004735 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 760192004736 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192004737 active site 760192004738 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 760192004739 Zn binding site [ion binding]; other site 760192004740 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760192004741 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 760192004742 Metal-binding active site; metal-binding site 760192004743 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 760192004744 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192004745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192004746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192004747 DNA binding residues [nucleotide binding] 760192004748 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 760192004749 dimer interface [polypeptide binding]; other site 760192004750 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 760192004751 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 760192004752 substrate binding site [chemical binding]; other site 760192004753 ligand binding site [chemical binding]; other site 760192004754 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 760192004755 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 760192004756 substrate binding site [chemical binding]; other site 760192004757 2-isopropylmalate synthase; Validated; Region: PRK00915 760192004758 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 760192004759 active site 760192004760 catalytic residues [active] 760192004761 metal binding site [ion binding]; metal-binding site 760192004762 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 760192004763 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 760192004764 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 760192004765 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192004766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 760192004767 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192004768 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192004769 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 760192004770 fumarylacetoacetase; Region: PLN02856 760192004771 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 760192004772 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 760192004773 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 760192004774 short chain dehydrogenase; Provisional; Region: PRK06197 760192004775 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 760192004776 putative NAD(P) binding site [chemical binding]; other site 760192004777 active site 760192004778 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 760192004779 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760192004780 substrate binding site [chemical binding]; other site 760192004781 ATP binding site [chemical binding]; other site 760192004782 MoxR-like ATPases [General function prediction only]; Region: COG0714 760192004783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192004784 Walker A motif; other site 760192004785 ATP binding site [chemical binding]; other site 760192004786 Walker B motif; other site 760192004787 arginine finger; other site 760192004788 multidrug efflux protein; Reviewed; Region: PRK01766 760192004789 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 760192004790 cation binding site [ion binding]; other site 760192004791 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 760192004792 oligomeric interface; other site 760192004793 putative active site [active] 760192004794 homodimer interface [polypeptide binding]; other site 760192004795 GTPase RsgA; Reviewed; Region: PRK00098 760192004796 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 760192004797 RNA binding site [nucleotide binding]; other site 760192004798 homodimer interface [polypeptide binding]; other site 760192004799 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 760192004800 GTPase/Zn-binding domain interface [polypeptide binding]; other site 760192004801 GTP/Mg2+ binding site [chemical binding]; other site 760192004802 G4 box; other site 760192004803 G5 box; other site 760192004804 G1 box; other site 760192004805 Switch I region; other site 760192004806 G2 box; other site 760192004807 G3 box; other site 760192004808 Switch II region; other site 760192004809 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 760192004810 PcrB family; Region: PcrB; pfam01884 760192004811 phosphate binding site [ion binding]; other site 760192004812 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 760192004813 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 760192004814 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004815 O-Antigen ligase; Region: Wzy_C; pfam04932 760192004816 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 760192004817 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 760192004818 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 760192004819 dimer interface [polypeptide binding]; other site 760192004820 motif 1; other site 760192004821 active site 760192004822 motif 2; other site 760192004823 motif 3; other site 760192004824 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 760192004825 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 760192004826 dimer interface [polypeptide binding]; other site 760192004827 motif 1; other site 760192004828 active site 760192004829 motif 2; other site 760192004830 motif 3; other site 760192004831 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 760192004832 anticodon binding site; other site 760192004833 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 760192004834 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 760192004835 Reprolysin family propeptide; Region: Pep_M12B_propep; pfam01562 760192004836 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 760192004837 active site 760192004838 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004839 Reprolysin family propeptide; Region: Pep_M12B_propep; pfam01562 760192004840 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 760192004841 active site 760192004842 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004843 argininosuccinate lyase; Provisional; Region: PRK00855 760192004844 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 760192004845 active sites [active] 760192004846 tetramer interface [polypeptide binding]; other site 760192004847 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 760192004848 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 760192004849 metal binding site [ion binding]; metal-binding site 760192004850 dimer interface [polypeptide binding]; other site 760192004851 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 760192004852 nucleotide binding site [chemical binding]; other site 760192004853 N-acetyl-L-glutamate binding site [chemical binding]; other site 760192004854 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192004855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 760192004856 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 760192004857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192004858 S-adenosylmethionine binding site [chemical binding]; other site 760192004859 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 760192004860 putative active site [active] 760192004861 Zn binding site [ion binding]; other site 760192004862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192004863 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192004864 Walker A motif; other site 760192004865 ATP binding site [chemical binding]; other site 760192004866 Walker B motif; other site 760192004867 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 760192004868 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 760192004869 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192004870 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 760192004871 active site 760192004872 oxyanion hole [active] 760192004873 catalytic triad [active] 760192004874 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 760192004875 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192004876 Two component regulator propeller; Region: Reg_prop; pfam07494 760192004877 Two component regulator propeller; Region: Reg_prop; pfam07494 760192004878 Two component regulator propeller; Region: Reg_prop; pfam07494 760192004879 Two component regulator propeller; Region: Reg_prop; pfam07494 760192004880 Two component regulator propeller; Region: Reg_prop; pfam07494 760192004881 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192004882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192004883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192004884 dimer interface [polypeptide binding]; other site 760192004885 phosphorylation site [posttranslational modification] 760192004886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192004887 ATP binding site [chemical binding]; other site 760192004888 Mg2+ binding site [ion binding]; other site 760192004889 G-X-G motif; other site 760192004890 Response regulator receiver domain; Region: Response_reg; pfam00072 760192004891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192004892 active site 760192004893 phosphorylation site [posttranslational modification] 760192004894 intermolecular recognition site; other site 760192004895 dimerization interface [polypeptide binding]; other site 760192004896 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 760192004897 cyclase homology domain; Region: CHD; cd07302 760192004898 nucleotidyl binding site; other site 760192004899 metal binding site [ion binding]; metal-binding site 760192004900 dimer interface [polypeptide binding]; other site 760192004901 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192004902 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192004903 structural tetrad; other site 760192004904 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192004905 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192004906 structural tetrad; other site 760192004907 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192004908 structural tetrad; other site 760192004909 Caspase domain; Region: Peptidase_C14; pfam00656 760192004910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192004911 TPR repeat; Region: TPR_11; pfam13414 760192004912 TPR motif; other site 760192004913 binding surface 760192004914 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 760192004915 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192004916 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 760192004917 Peptidase family M1; Region: Peptidase_M1; pfam01433 760192004918 Zn binding site [ion binding]; other site 760192004919 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 760192004920 DinB family; Region: DinB; cl17821 760192004921 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 760192004922 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 760192004923 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 760192004924 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 760192004925 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 760192004926 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 760192004927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 760192004928 ATP binding site [chemical binding]; other site 760192004929 Mg2+ binding site [ion binding]; other site 760192004930 G-X-G motif; other site 760192004931 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 760192004932 ATP binding site [chemical binding]; other site 760192004933 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 760192004934 active site 760192004935 putative metal-binding site [ion binding]; other site 760192004936 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 760192004937 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192004938 putative active site [active] 760192004939 Tetratricopeptide repeat; Region: TPR_16; pfam13432 760192004940 Tetratricopeptide repeat; Region: TPR_9; pfam13371 760192004941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192004942 TPR motif; other site 760192004943 binding surface 760192004944 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192004945 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192004946 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192004947 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192004948 ligand binding site [chemical binding]; other site 760192004949 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 760192004950 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 760192004951 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192004952 FtsX-like permease family; Region: FtsX; pfam02687 760192004953 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 760192004954 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 760192004955 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192004956 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760192004957 Walker A/P-loop; other site 760192004958 ATP binding site [chemical binding]; other site 760192004959 Q-loop/lid; other site 760192004960 ABC transporter signature motif; other site 760192004961 Walker B; other site 760192004962 D-loop; other site 760192004963 H-loop/switch region; other site 760192004964 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 760192004965 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 760192004966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192004967 catalytic residue [active] 760192004968 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192004969 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760192004970 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192004971 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192004972 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192004973 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192004974 Asp-box motif; other site 760192004975 BNR repeat-like domain; Region: BNR_2; pfam13088 760192004976 AAA domain; Region: AAA_21; pfam13304 760192004977 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 760192004978 Peptidase family M50; Region: Peptidase_M50; pfam02163 760192004979 active site 760192004980 putative substrate binding region [chemical binding]; other site 760192004981 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 760192004982 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 760192004983 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 760192004984 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 760192004985 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 760192004986 active site 760192004987 putative DNA-binding cleft [nucleotide binding]; other site 760192004988 dimer interface [polypeptide binding]; other site 760192004989 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 760192004990 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192004991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192004992 catalytic residue [active] 760192004993 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192004994 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 760192004995 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192004996 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 760192004997 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 760192004998 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 760192004999 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192005000 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 760192005001 Restriction endonuclease; Region: Mrr_cat; pfam04471 760192005002 Domain of unknown function (DUF955); Region: DUF955; pfam06114 760192005003 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 760192005004 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 760192005005 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 760192005006 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 760192005007 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 760192005008 substrate binding pocket [chemical binding]; other site 760192005009 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 760192005010 B12 binding site [chemical binding]; other site 760192005011 cobalt ligand [ion binding]; other site 760192005012 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 760192005013 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192005014 dockerin binding interface; other site 760192005015 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192005016 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192005017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192005018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192005019 dimer interface [polypeptide binding]; other site 760192005020 phosphorylation site [posttranslational modification] 760192005021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192005022 ATP binding site [chemical binding]; other site 760192005023 Mg2+ binding site [ion binding]; other site 760192005024 G-X-G motif; other site 760192005025 Response regulator receiver domain; Region: Response_reg; pfam00072 760192005026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192005027 active site 760192005028 phosphorylation site [posttranslational modification] 760192005029 intermolecular recognition site; other site 760192005030 dimerization interface [polypeptide binding]; other site 760192005031 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192005032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192005033 Two component regulator propeller; Region: Reg_prop; pfam07494 760192005034 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192005035 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192005036 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 760192005037 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 760192005038 NADP binding site [chemical binding]; other site 760192005039 putative substrate binding site [chemical binding]; other site 760192005040 active site 760192005041 Caspase domain; Region: Peptidase_C14; pfam00656 760192005042 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192005043 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192005044 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 760192005045 N-acetyl-D-glucosamine binding site [chemical binding]; other site 760192005046 catalytic residue [active] 760192005047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192005048 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 760192005049 MoaE interaction surface [polypeptide binding]; other site 760192005050 MoeB interaction surface [polypeptide binding]; other site 760192005051 thiocarboxylated glycine; other site 760192005052 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 760192005053 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760192005054 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760192005055 active site 760192005056 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 760192005057 four helix bundle protein; Region: TIGR02436 760192005058 amino acid transporter; Region: 2A0306; TIGR00909 760192005059 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 760192005060 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192005061 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192005062 Heme NO binding associated; Region: HNOBA; pfam07701 760192005063 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 760192005064 cyclase homology domain; Region: CHD; cd07302 760192005065 nucleotidyl binding site; other site 760192005066 metal binding site [ion binding]; metal-binding site 760192005067 dimer interface [polypeptide binding]; other site 760192005068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760192005069 Zn2+ binding site [ion binding]; other site 760192005070 Mg2+ binding site [ion binding]; other site 760192005071 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 760192005072 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192005073 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 760192005074 active site 760192005075 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 760192005076 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 760192005077 GIY-YIG motif/motif A; other site 760192005078 active site 760192005079 catalytic site [active] 760192005080 putative DNA binding site [nucleotide binding]; other site 760192005081 metal binding site [ion binding]; metal-binding site 760192005082 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 760192005083 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 760192005084 putative DNA binding site [nucleotide binding]; other site 760192005085 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 760192005086 amidase catalytic site [active] 760192005087 Zn binding residues [ion binding]; other site 760192005088 substrate binding site [chemical binding]; other site 760192005089 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192005090 Ion channel; Region: Ion_trans_2; pfam07885 760192005091 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 760192005092 TrkA-N domain; Region: TrkA_N; pfam02254 760192005093 TrkA-C domain; Region: TrkA_C; pfam02080 760192005094 Amidohydrolase; Region: Amidohydro_2; pfam04909 760192005095 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192005096 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 760192005097 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 760192005098 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 760192005099 AAA domain; Region: AAA_14; pfam13173 760192005100 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192005101 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 760192005102 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 760192005103 HEAT repeats; Region: HEAT_2; pfam13646 760192005104 protein binding surface [polypeptide binding]; other site 760192005105 HEAT repeats; Region: HEAT_2; pfam13646 760192005106 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 760192005107 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192005108 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192005109 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192005110 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192005111 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 760192005112 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192005113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192005114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192005115 active site 760192005116 phosphorylation site [posttranslational modification] 760192005117 intermolecular recognition site; other site 760192005118 dimerization interface [polypeptide binding]; other site 760192005119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192005120 DNA binding residues [nucleotide binding] 760192005121 dimerization interface [polypeptide binding]; other site 760192005122 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760192005123 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760192005124 nucleotide binding site [chemical binding]; other site 760192005125 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192005126 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192005127 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 760192005128 active site 760192005129 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 760192005130 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005131 FtsX-like permease family; Region: FtsX; pfam02687 760192005132 XisI protein; Region: XisI; pfam08869 760192005133 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192005134 putative active site [active] 760192005135 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 760192005136 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192005137 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192005138 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192005139 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 760192005140 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 760192005141 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 760192005142 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192005143 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192005144 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192005145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192005146 active site 760192005147 phosphorylation site [posttranslational modification] 760192005148 intermolecular recognition site; other site 760192005149 dimerization interface [polypeptide binding]; other site 760192005150 LytTr DNA-binding domain; Region: LytTR; smart00850 760192005151 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 760192005152 Penicillinase repressor; Region: Pencillinase_R; cl17580 760192005153 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 760192005154 Histidine kinase; Region: His_kinase; pfam06580 760192005155 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192005156 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192005157 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192005158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192005159 putative substrate translocation pore; other site 760192005160 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 760192005161 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 760192005162 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 760192005163 Penicillinase repressor; Region: Pencillinase_R; pfam03965 760192005164 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192005165 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192005166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 760192005167 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192005168 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192005169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005170 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192005171 FtsX-like permease family; Region: FtsX; pfam02687 760192005172 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005173 FtsX-like permease family; Region: FtsX; pfam02687 760192005174 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 760192005175 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 760192005176 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 760192005177 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 760192005178 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 760192005179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760192005180 ATP binding site [chemical binding]; other site 760192005181 putative Mg++ binding site [ion binding]; other site 760192005182 TIGR02646 family protein; Region: TIGR02646 760192005183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192005184 AAA domain; Region: AAA_21; pfam13304 760192005185 Walker A/P-loop; other site 760192005186 ATP binding site [chemical binding]; other site 760192005187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192005188 ABC transporter signature motif; other site 760192005189 Walker B; other site 760192005190 D-loop; other site 760192005191 H-loop/switch region; other site 760192005192 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760192005193 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 760192005194 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760192005195 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 760192005196 HsdM N-terminal domain; Region: HsdM_N; pfam12161 760192005197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192005198 S-adenosylmethionine binding site [chemical binding]; other site 760192005199 Predicted transcriptional regulators [Transcription]; Region: COG1695 760192005200 Transcriptional regulator PadR-like family; Region: PadR; cl17335 760192005201 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192005202 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005203 FtsX-like permease family; Region: FtsX; pfam02687 760192005204 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005205 FtsX-like permease family; Region: FtsX; pfam02687 760192005206 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760192005207 Transcriptional regulator PadR-like family; Region: PadR; cl17335 760192005208 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192005209 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005210 FtsX-like permease family; Region: FtsX; pfam02687 760192005211 FtsX-like permease family; Region: FtsX; pfam02687 760192005212 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005213 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192005214 FtsX-like permease family; Region: FtsX; pfam02687 760192005215 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005216 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192005217 FtsX-like permease family; Region: FtsX; pfam02687 760192005218 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192005219 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 760192005220 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 760192005221 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192005222 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 760192005223 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_4; cd08976 760192005224 putative DNA binding site [nucleotide binding]; other site 760192005225 catalytic residue [active] 760192005226 putative H2TH interface [polypeptide binding]; other site 760192005227 putative catalytic residues [active] 760192005228 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 760192005229 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 760192005230 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 760192005231 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 760192005232 active site 760192005233 catalytic site [active] 760192005234 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 760192005235 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 760192005236 conserved cys residue [active] 760192005237 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 760192005238 FAD binding domain; Region: FAD_binding_4; pfam01565 760192005239 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 760192005240 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 760192005241 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192005242 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 760192005243 Cytochrome c; Region: Cytochrom_C; pfam00034 760192005244 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 760192005245 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 760192005246 ligand binding site [chemical binding]; other site 760192005247 NAD binding site [chemical binding]; other site 760192005248 dimerization interface [polypeptide binding]; other site 760192005249 catalytic site [active] 760192005250 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192005251 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 760192005252 dimer interface [polypeptide binding]; other site 760192005253 putative metal binding site [ion binding]; other site 760192005254 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 760192005255 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 760192005256 active site pocket [active] 760192005257 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760192005258 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 760192005259 active site 760192005260 catalytic triad [active] 760192005261 oxyanion hole [active] 760192005262 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192005263 HEAT repeats; Region: HEAT_2; pfam13646 760192005264 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 760192005265 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192005266 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 760192005267 Colicin V production protein; Region: Colicin_V; pfam02674 760192005268 YhhN-like protein; Region: YhhN; pfam07947 760192005269 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 760192005270 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 760192005271 active site 760192005272 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 760192005273 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 760192005274 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 760192005275 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 760192005276 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 760192005277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192005278 FeS/SAM binding site; other site 760192005279 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 760192005280 TPR repeat; Region: TPR_11; pfam13414 760192005281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192005282 binding surface 760192005283 TPR motif; other site 760192005284 TPR repeat; Region: TPR_11; pfam13414 760192005285 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 760192005286 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 760192005287 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 760192005288 Gram-negative bacterial tonB protein; Region: TonB; cl10048 760192005289 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192005290 Protein of unknown function (DUF419); Region: DUF419; pfam04237 760192005291 Penicillinase repressor; Region: Pencillinase_R; pfam03965 760192005292 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 760192005293 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192005294 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192005295 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192005296 Sulfatase; Region: Sulfatase; pfam00884 760192005297 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192005298 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192005299 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 760192005300 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 760192005301 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192005302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192005303 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192005304 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192005305 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192005306 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 760192005307 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 760192005308 BNR repeat-like domain; Region: BNR_2; pfam13088 760192005309 BNR repeat-like domain; Region: BNR_2; pfam13088 760192005310 hypothetical protein; Provisional; Region: PRK12378 760192005311 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 760192005312 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 760192005313 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 760192005314 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 760192005315 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 760192005316 active site 760192005317 catalytic residues [active] 760192005318 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 760192005319 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 760192005320 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 760192005321 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 760192005322 HerA helicase [Replication, recombination, and repair]; Region: COG0433 760192005323 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 760192005324 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 760192005325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192005326 Walker A motif; other site 760192005327 ATP binding site [chemical binding]; other site 760192005328 Walker B motif; other site 760192005329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 760192005330 Integrase core domain; Region: rve; pfam00665 760192005331 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 760192005332 PLD-like domain; Region: PLDc_2; pfam13091 760192005333 homodimer interface [polypeptide binding]; other site 760192005334 putative active site [active] 760192005335 catalytic site [active] 760192005336 AAA ATPase domain; Region: AAA_16; pfam13191 760192005337 AAA domain; Region: AAA_22; pfam13401 760192005338 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192005339 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192005340 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192005341 structural tetrad; other site 760192005342 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192005343 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192005344 structural tetrad; other site 760192005345 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192005346 structural tetrad; other site 760192005347 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192005348 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 760192005349 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 760192005350 Helix-turn-helix domain; Region: HTH_17; pfam12728 760192005351 Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326 760192005352 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005353 FtsX-like permease family; Region: FtsX; pfam02687 760192005354 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005355 FtsX-like permease family; Region: FtsX; pfam02687 760192005356 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 760192005357 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 760192005358 metal binding site [ion binding]; metal-binding site 760192005359 substrate binding pocket [chemical binding]; other site 760192005360 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 760192005361 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 760192005362 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 760192005363 fructuronate transporter; Provisional; Region: PRK10034; cl15264 760192005364 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 760192005365 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192005366 HEAT repeats; Region: HEAT_2; pfam13646 760192005367 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 760192005368 Cytochrome c; Region: Cytochrom_C; pfam00034 760192005369 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 760192005370 AP (apurinic/apyrimidinic) site pocket; other site 760192005371 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192005372 DNA interaction; other site 760192005373 Metal-binding active site; metal-binding site 760192005374 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005375 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192005376 FtsX-like permease family; Region: FtsX; pfam02687 760192005377 FtsX-like permease family; Region: FtsX; pfam02687 760192005378 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192005379 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760192005380 Walker A/P-loop; other site 760192005381 ATP binding site [chemical binding]; other site 760192005382 Q-loop/lid; other site 760192005383 ABC transporter signature motif; other site 760192005384 Walker B; other site 760192005385 D-loop; other site 760192005386 H-loop/switch region; other site 760192005387 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 760192005388 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 760192005389 glycogen branching enzyme; Provisional; Region: PRK12313 760192005390 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 760192005391 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 760192005392 active site 760192005393 catalytic site [active] 760192005394 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 760192005395 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192005396 putative active site [active] 760192005397 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 760192005398 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 760192005399 putative NADP binding site [chemical binding]; other site 760192005400 putative substrate binding site [chemical binding]; other site 760192005401 active site 760192005402 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 760192005403 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192005404 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 760192005405 Zn binding site [ion binding]; other site 760192005406 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760192005407 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192005408 catalytic residues [active] 760192005409 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 760192005410 putative FMN binding site [chemical binding]; other site 760192005411 putative dimer interface [polypeptide binding]; other site 760192005412 NRDE protein; Region: NRDE; cl01315 760192005413 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192005414 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 760192005415 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 760192005416 putative dimer interface [polypeptide binding]; other site 760192005417 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 760192005418 putative ligand binding site [chemical binding]; other site 760192005419 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192005420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192005421 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 760192005422 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 760192005423 putative hydrophobic ligand binding site [chemical binding]; other site 760192005424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 760192005425 Gram-negative bacterial tonB protein; Region: TonB; cl10048 760192005426 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 760192005427 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 760192005428 tetrameric interface [polypeptide binding]; other site 760192005429 activator binding site; other site 760192005430 NADP binding site [chemical binding]; other site 760192005431 substrate binding site [chemical binding]; other site 760192005432 catalytic residues [active] 760192005433 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192005434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192005435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192005436 DNA binding residues [nucleotide binding] 760192005437 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192005438 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192005439 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192005440 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192005441 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192005442 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192005443 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192005444 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192005445 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 760192005446 Na2 binding site [ion binding]; other site 760192005447 substrate binding site 1 [chemical binding]; other site 760192005448 Na binding site 1 [ion binding]; other site 760192005449 substrate binding site 2 [chemical binding]; other site 760192005450 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 760192005451 trimer interface [polypeptide binding]; other site 760192005452 active site 760192005453 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192005454 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192005455 structural tetrad; other site 760192005456 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 760192005457 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 760192005458 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 760192005459 Response regulator receiver domain; Region: Response_reg; pfam00072 760192005460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192005461 active site 760192005462 phosphorylation site [posttranslational modification] 760192005463 intermolecular recognition site; other site 760192005464 dimerization interface [polypeptide binding]; other site 760192005465 LytTr DNA-binding domain; Region: LytTR; smart00850 760192005466 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 760192005467 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 760192005468 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 760192005469 active site 760192005470 substrate-binding site [chemical binding]; other site 760192005471 metal-binding site [ion binding] 760192005472 GTP binding site [chemical binding]; other site 760192005473 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 760192005474 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 760192005475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192005476 sequence-specific DNA binding site [nucleotide binding]; other site 760192005477 salt bridge; other site 760192005478 Virulence protein [General function prediction only]; Region: COG3943 760192005479 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 760192005480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192005481 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192005482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192005483 Walker A/P-loop; other site 760192005484 ATP binding site [chemical binding]; other site 760192005485 Q-loop/lid; other site 760192005486 ABC transporter signature motif; other site 760192005487 Walker B; other site 760192005488 D-loop; other site 760192005489 H-loop/switch region; other site 760192005490 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192005491 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 760192005492 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 760192005493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192005494 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192005495 putative substrate translocation pore; other site 760192005496 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 760192005497 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 760192005498 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 760192005499 active site 760192005500 dimer interface [polypeptide binding]; other site 760192005501 effector binding site; other site 760192005502 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 760192005503 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 760192005504 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192005505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192005506 DNA binding residues [nucleotide binding] 760192005507 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 760192005508 FecR protein; Region: FecR; pfam04773 760192005509 Secretin and TonB N terminus short domain; Region: STN; pfam07660 760192005510 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 760192005511 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760192005512 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192005513 active site residue [active] 760192005514 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192005515 active site residue [active] 760192005516 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 760192005517 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 760192005518 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 760192005519 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 760192005520 B12 binding site [chemical binding]; other site 760192005521 cobalt ligand [ion binding]; other site 760192005522 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760192005523 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 760192005524 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 760192005525 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 760192005526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192005527 Coenzyme A binding pocket [chemical binding]; other site 760192005528 Domain of unknown function (DUF377); Region: DUF377; pfam04041 760192005529 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 760192005530 active site 760192005531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192005532 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 760192005533 active site 760192005534 metal binding site [ion binding]; metal-binding site 760192005535 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 760192005536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760192005537 DNA-binding site [nucleotide binding]; DNA binding site 760192005538 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760192005539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192005540 homodimer interface [polypeptide binding]; other site 760192005541 catalytic residue [active] 760192005542 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 760192005543 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 760192005544 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 760192005545 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 760192005546 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 760192005547 active site 760192005548 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 760192005549 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 760192005550 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192005551 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 760192005552 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192005553 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 760192005554 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005555 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 760192005556 FtsX-like permease family; Region: FtsX; pfam02687 760192005557 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192005558 FtsX-like permease family; Region: FtsX; pfam02687 760192005559 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192005560 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760192005561 Walker A/P-loop; other site 760192005562 ATP binding site [chemical binding]; other site 760192005563 Q-loop/lid; other site 760192005564 ABC transporter signature motif; other site 760192005565 Walker B; other site 760192005566 D-loop; other site 760192005567 H-loop/switch region; other site 760192005568 Outer membrane efflux protein; Region: OEP; pfam02321 760192005569 Outer membrane efflux protein; Region: OEP; pfam02321 760192005570 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 760192005571 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192005572 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 760192005573 oligomeric interface; other site 760192005574 putative active site [active] 760192005575 homodimer interface [polypeptide binding]; other site 760192005576 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 760192005577 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192005578 active site 760192005579 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 760192005580 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 760192005581 active site 760192005582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192005583 active site 760192005584 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 760192005585 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 760192005586 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192005587 Beta-lactamase; Region: Beta-lactamase; cl17358 760192005588 EamA-like transporter family; Region: EamA; pfam00892 760192005589 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 760192005590 EamA-like transporter family; Region: EamA; pfam00892 760192005591 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 760192005592 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 760192005593 putative dimer interface [polypeptide binding]; other site 760192005594 putative anticodon binding site; other site 760192005595 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 760192005596 homodimer interface [polypeptide binding]; other site 760192005597 motif 1; other site 760192005598 motif 2; other site 760192005599 active site 760192005600 motif 3; other site 760192005601 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 760192005602 DNA repair protein RadA; Provisional; Region: PRK11823 760192005603 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 760192005604 Walker A motif/ATP binding site; other site 760192005605 ATP binding site [chemical binding]; other site 760192005606 Walker B motif; other site 760192005607 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 760192005608 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760192005609 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760192005610 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192005611 active site residue [active] 760192005612 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 760192005613 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 760192005614 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 760192005615 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192005616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 760192005617 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 760192005618 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 760192005619 active site 760192005620 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 760192005621 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192005622 Ribosome-binding factor A; Region: RBFA; pfam02033 760192005623 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 760192005624 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 760192005625 generic binding surface II; other site 760192005626 ssDNA binding site; other site 760192005627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192005628 ATP binding site [chemical binding]; other site 760192005629 putative Mg++ binding site [ion binding]; other site 760192005630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192005631 nucleotide binding region [chemical binding]; other site 760192005632 ATP-binding site [chemical binding]; other site 760192005633 CUT domain; Region: CUT; pfam02376 760192005634 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 760192005635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 760192005636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 760192005637 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192005638 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 760192005639 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760192005640 putative switch regulator; other site 760192005641 non-specific DNA interactions [nucleotide binding]; other site 760192005642 DNA binding site [nucleotide binding] 760192005643 sequence specific DNA binding site [nucleotide binding]; other site 760192005644 putative cAMP binding site [chemical binding]; other site 760192005645 Protein of unknown function (DUF983); Region: DUF983; cl02211 760192005646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192005647 dimerization interface [polypeptide binding]; other site 760192005648 putative DNA binding site [nucleotide binding]; other site 760192005649 putative Zn2+ binding site [ion binding]; other site 760192005650 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 760192005651 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 760192005652 Walker A/P-loop; other site 760192005653 ATP binding site [chemical binding]; other site 760192005654 Q-loop/lid; other site 760192005655 ABC transporter signature motif; other site 760192005656 Walker B; other site 760192005657 D-loop; other site 760192005658 H-loop/switch region; other site 760192005659 Permease; Region: Permease; pfam02405 760192005660 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760192005661 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192005662 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192005663 ligand binding site [chemical binding]; other site 760192005664 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192005665 Amidohydrolase; Region: Amidohydro_4; pfam13147 760192005666 active site 760192005667 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 760192005668 Uncharacterized conserved protein [Function unknown]; Region: COG4198 760192005669 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 760192005670 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 760192005671 active site 760192005672 HIGH motif; other site 760192005673 KMSKS motif; other site 760192005674 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 760192005675 tRNA binding surface [nucleotide binding]; other site 760192005676 anticodon binding site; other site 760192005677 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 760192005678 dimer interface [polypeptide binding]; other site 760192005679 putative tRNA-binding site [nucleotide binding]; other site 760192005680 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192005681 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192005682 ligand binding site [chemical binding]; other site 760192005683 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192005684 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192005685 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192005686 active site 760192005687 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 760192005688 nudix motif; other site 760192005689 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 760192005690 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 760192005691 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 760192005692 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 760192005693 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 760192005694 putative trimer interface [polypeptide binding]; other site 760192005695 putative CoA binding site [chemical binding]; other site 760192005696 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760192005697 cysteine synthase B; Region: cysM; TIGR01138 760192005698 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 760192005699 dimer interface [polypeptide binding]; other site 760192005700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192005701 catalytic residue [active] 760192005702 serine O-acetyltransferase; Region: cysE; TIGR01172 760192005703 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 760192005704 trimer interface [polypeptide binding]; other site 760192005705 active site 760192005706 substrate binding site [chemical binding]; other site 760192005707 CoA binding site [chemical binding]; other site 760192005708 enoyl-CoA hydratase; Provisional; Region: PRK08140 760192005709 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 760192005710 substrate binding site [chemical binding]; other site 760192005711 oxyanion hole (OAH) forming residues; other site 760192005712 trimer interface [polypeptide binding]; other site 760192005713 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 760192005714 membrane ATPase/protein kinase; Provisional; Region: PRK09435 760192005715 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 760192005716 Walker A; other site 760192005717 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192005718 G4 box; other site 760192005719 G5 box; other site 760192005720 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 760192005721 Repair protein; Region: Repair_PSII; pfam04536 760192005722 Repair protein; Region: Repair_PSII; pfam04536 760192005723 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 760192005724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192005725 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192005726 Walker A motif; other site 760192005727 ATP binding site [chemical binding]; other site 760192005728 Walker B motif; other site 760192005729 arginine finger; other site 760192005730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 760192005731 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192005732 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192005733 structural tetrad; other site 760192005734 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 760192005735 YceI-like domain; Region: YceI; pfam04264 760192005736 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192005737 Haem-binding domain; Region: Haem_bd; pfam14376 760192005738 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 760192005739 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192005740 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 760192005741 Outer membrane efflux protein; Region: OEP; pfam02321 760192005742 Outer membrane efflux protein; Region: OEP; pfam02321 760192005743 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 760192005744 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 760192005745 dinuclear metal binding motif [ion binding]; other site 760192005746 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 760192005747 catalytic residues [active] 760192005748 dimer interface [polypeptide binding]; other site 760192005749 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 760192005750 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 760192005751 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 760192005752 elongation factor G; Reviewed; Region: PRK12740 760192005753 G1 box; other site 760192005754 putative GEF interaction site [polypeptide binding]; other site 760192005755 GTP/Mg2+ binding site [chemical binding]; other site 760192005756 Switch I region; other site 760192005757 G2 box; other site 760192005758 G3 box; other site 760192005759 Switch II region; other site 760192005760 G4 box; other site 760192005761 G5 box; other site 760192005762 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 760192005763 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 760192005764 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 760192005765 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 760192005766 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 760192005767 homodimer interface [polypeptide binding]; other site 760192005768 substrate-cofactor binding pocket; other site 760192005769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192005770 catalytic residue [active] 760192005771 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192005772 putative active site [active] 760192005773 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 760192005774 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 760192005775 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 760192005776 catalytic triad [active] 760192005777 putative active site [active] 760192005778 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192005779 Interdomain contacts; other site 760192005780 Cytokine receptor motif; other site 760192005781 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192005782 Interdomain contacts; other site 760192005783 Cytokine receptor motif; other site 760192005784 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192005785 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 760192005786 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760192005787 Walker A/P-loop; other site 760192005788 ATP binding site [chemical binding]; other site 760192005789 Q-loop/lid; other site 760192005790 ABC transporter signature motif; other site 760192005791 Walker B; other site 760192005792 D-loop; other site 760192005793 H-loop/switch region; other site 760192005794 ABC transporter; Region: ABC_tran_2; pfam12848 760192005795 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760192005796 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 760192005797 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 760192005798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192005799 Walker A/P-loop; other site 760192005800 ATP binding site [chemical binding]; other site 760192005801 Q-loop/lid; other site 760192005802 ABC transporter signature motif; other site 760192005803 Walker B; other site 760192005804 D-loop; other site 760192005805 H-loop/switch region; other site 760192005806 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 760192005807 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 760192005808 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 760192005809 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 760192005810 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 760192005811 Domain interface; other site 760192005812 Active site tetrad [active] 760192005813 Peptide binding site; other site 760192005814 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 760192005815 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 760192005816 FOG: CBS domain [General function prediction only]; Region: COG0517 760192005817 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 760192005818 Uncharacterized conserved protein [Function unknown]; Region: COG3743 760192005819 Uncharacterized conserved protein [Function unknown]; Region: COG3743 760192005820 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 760192005821 ligand binding site [chemical binding]; other site 760192005822 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192005823 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192005824 ligand binding site [chemical binding]; other site 760192005825 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 760192005826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192005827 active site 760192005828 phosphorylation site [posttranslational modification] 760192005829 intermolecular recognition site; other site 760192005830 dimerization interface [polypeptide binding]; other site 760192005831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192005832 Walker A motif; other site 760192005833 ATP binding site [chemical binding]; other site 760192005834 Walker B motif; other site 760192005835 arginine finger; other site 760192005836 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760192005837 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 760192005838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192005839 ATP binding site [chemical binding]; other site 760192005840 Mg2+ binding site [ion binding]; other site 760192005841 G-X-G motif; other site 760192005842 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 760192005843 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 760192005844 dimerization interface 3.5A [polypeptide binding]; other site 760192005845 active site 760192005846 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 760192005847 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192005848 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 760192005849 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192005850 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192005851 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 760192005852 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192005853 catalytic loop [active] 760192005854 iron binding site [ion binding]; other site 760192005855 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 760192005856 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 760192005857 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 760192005858 putative metal binding site; other site 760192005859 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 760192005860 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 760192005861 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 760192005862 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 760192005863 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 760192005864 active site 760192005865 dimer interface [polypeptide binding]; other site 760192005866 motif 1; other site 760192005867 motif 2; other site 760192005868 motif 3; other site 760192005869 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 760192005870 anticodon binding site; other site 760192005871 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192005872 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 760192005873 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 760192005874 metal ion-dependent adhesion site (MIDAS); other site 760192005875 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192005876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192005877 Walker A motif; other site 760192005878 ATP binding site [chemical binding]; other site 760192005879 Walker B motif; other site 760192005880 arginine finger; other site 760192005881 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 760192005882 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 760192005883 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 760192005884 AAA ATPase domain; Region: AAA_16; pfam13191 760192005885 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192005886 AAA ATPase domain; Region: AAA_16; pfam13191 760192005887 NACHT domain; Region: NACHT; pfam05729 760192005888 Walker A motif; other site 760192005889 ATP binding site [chemical binding]; other site 760192005890 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 760192005891 oligomeric interface; other site 760192005892 putative active site [active] 760192005893 homodimer interface [polypeptide binding]; other site 760192005894 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192005895 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192005896 ligand binding site [chemical binding]; other site 760192005897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760192005898 Zn2+ binding site [ion binding]; other site 760192005899 Mg2+ binding site [ion binding]; other site 760192005900 4Fe-4S binding domain; Region: Fer4_5; pfam12801 760192005901 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 760192005902 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 760192005903 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 760192005904 Ferredoxin [Energy production and conversion]; Region: COG1146 760192005905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 760192005906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192005907 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192005908 Methyltransferase domain; Region: Methyltransf_31; pfam13847 760192005909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192005910 S-adenosylmethionine binding site [chemical binding]; other site 760192005911 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 760192005912 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 760192005913 active site lid residues [active] 760192005914 substrate binding pocket [chemical binding]; other site 760192005915 catalytic residues [active] 760192005916 substrate-Mg2+ binding site; other site 760192005917 aspartate-rich region 1; other site 760192005918 aspartate-rich region 2; other site 760192005919 phytoene desaturase; Region: crtI_fam; TIGR02734 760192005920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192005921 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 760192005922 hexamer interface [polypeptide binding]; other site 760192005923 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 760192005924 Walker A motif; other site 760192005925 ATP binding site [chemical binding]; other site 760192005926 Walker B motif; other site 760192005927 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 760192005928 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 760192005929 catalytic residue [active] 760192005930 putative FPP diphosphate binding site; other site 760192005931 putative FPP binding hydrophobic cleft; other site 760192005932 dimer interface [polypeptide binding]; other site 760192005933 putative IPP diphosphate binding site; other site 760192005934 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 760192005935 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 760192005936 active site 760192005937 Zn binding site [ion binding]; other site 760192005938 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 760192005939 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 760192005940 Mg++ binding site [ion binding]; other site 760192005941 putative catalytic motif [active] 760192005942 substrate binding site [chemical binding]; other site 760192005943 purine nucleoside phosphorylase; Provisional; Region: PRK08202 760192005944 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 760192005945 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 760192005946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192005947 Coenzyme A binding pocket [chemical binding]; other site 760192005948 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192005949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192005950 non-specific DNA binding site [nucleotide binding]; other site 760192005951 salt bridge; other site 760192005952 sequence-specific DNA binding site [nucleotide binding]; other site 760192005953 Domain of unknown function (DUF955); Region: DUF955; cl01076 760192005954 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 760192005955 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 760192005956 putative active site [active] 760192005957 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 760192005958 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192005959 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 760192005960 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 760192005961 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 760192005962 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 760192005963 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192005964 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 760192005965 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 760192005966 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 760192005967 substrate binding site [chemical binding]; other site 760192005968 ligand binding site [chemical binding]; other site 760192005969 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 760192005970 substrate binding site [chemical binding]; other site 760192005971 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 760192005972 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192005973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192005974 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 760192005975 active site 760192005976 Uncharacterized conserved protein [Function unknown]; Region: COG3342 760192005977 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 760192005978 TPR repeat; Region: TPR_11; pfam13414 760192005979 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 760192005980 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192005981 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192005982 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 760192005983 Walker A/P-loop; other site 760192005984 ATP binding site [chemical binding]; other site 760192005985 Q-loop/lid; other site 760192005986 ABC transporter signature motif; other site 760192005987 Walker B; other site 760192005988 D-loop; other site 760192005989 H-loop/switch region; other site 760192005990 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 760192005991 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 760192005992 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 760192005993 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 760192005994 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 760192005995 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 760192005996 carboxyltransferase (CT) interaction site; other site 760192005997 biotinylation site [posttranslational modification]; other site 760192005998 elongation factor P; Validated; Region: PRK00529 760192005999 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 760192006000 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 760192006001 RNA binding site [nucleotide binding]; other site 760192006002 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 760192006003 RNA binding site [nucleotide binding]; other site 760192006004 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 760192006005 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 760192006006 dimer interface [polypeptide binding]; other site 760192006007 active site 760192006008 CoA binding pocket [chemical binding]; other site 760192006009 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 760192006010 Na binding site [ion binding]; other site 760192006011 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 760192006012 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192006013 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 760192006014 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 760192006015 Predicted amidohydrolase [General function prediction only]; Region: COG0388 760192006016 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 760192006017 putative active site [active] 760192006018 catalytic triad [active] 760192006019 putative dimer interface [polypeptide binding]; other site 760192006020 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192006021 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192006022 Inward rectifier potassium channel; Region: IRK; pfam01007 760192006023 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 760192006024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 760192006025 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 760192006026 ATP binding site [chemical binding]; other site 760192006027 Mg2+ binding site [ion binding]; other site 760192006028 G-X-G motif; other site 760192006029 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 760192006030 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 760192006031 homodimer interface [polypeptide binding]; other site 760192006032 substrate-cofactor binding pocket; other site 760192006033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192006034 catalytic residue [active] 760192006035 Amino acid permease; Region: AA_permease_2; pfam13520 760192006036 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 760192006037 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192006038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192006039 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192006040 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 760192006041 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 760192006042 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 760192006043 Sulfate transporter family; Region: Sulfate_transp; pfam00916 760192006044 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 760192006045 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192006046 active site residue [active] 760192006047 Cytochrome c [Energy production and conversion]; Region: COG3258 760192006048 Cytochrome c; Region: Cytochrom_C; pfam00034 760192006049 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 760192006050 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760192006051 active site 760192006052 metal binding site [ion binding]; metal-binding site 760192006053 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 760192006054 DsrE/DsrF-like family; Region: DrsE; pfam02635 760192006055 quinolinate synthetase; Provisional; Region: PRK09375 760192006056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192006057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192006058 active site 760192006059 phosphorylation site [posttranslational modification] 760192006060 intermolecular recognition site; other site 760192006061 dimerization interface [polypeptide binding]; other site 760192006062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192006063 DNA binding residues [nucleotide binding] 760192006064 dimerization interface [polypeptide binding]; other site 760192006065 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192006066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192006067 Histidine kinase; Region: HisKA_3; pfam07730 760192006068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192006069 ATP binding site [chemical binding]; other site 760192006070 Mg2+ binding site [ion binding]; other site 760192006071 G-X-G motif; other site 760192006072 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 760192006073 Transposase [DNA replication, recombination, and repair]; Region: COG5433 760192006074 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 760192006075 CAAX protease self-immunity; Region: Abi; pfam02517 760192006076 HTH domain; Region: HTH_11; cl17392 760192006077 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 760192006078 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 760192006079 putative active site [active] 760192006080 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192006081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192006082 Walker A/P-loop; other site 760192006083 ATP binding site [chemical binding]; other site 760192006084 Q-loop/lid; other site 760192006085 ABC transporter signature motif; other site 760192006086 Walker B; other site 760192006087 D-loop; other site 760192006088 H-loop/switch region; other site 760192006089 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 760192006090 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192006091 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 760192006092 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 760192006093 Walker A/P-loop; other site 760192006094 ATP binding site [chemical binding]; other site 760192006095 Q-loop/lid; other site 760192006096 ABC transporter signature motif; other site 760192006097 Walker B; other site 760192006098 D-loop; other site 760192006099 H-loop/switch region; other site 760192006100 acyl carrier protein; Provisional; Region: acpP; PRK00982 760192006101 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 760192006102 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 760192006103 dimer interface [polypeptide binding]; other site 760192006104 active site 760192006105 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 760192006106 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 760192006107 dimerization interface [polypeptide binding]; other site 760192006108 active site 760192006109 metal binding site [ion binding]; metal-binding site 760192006110 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 760192006111 dsRNA binding site [nucleotide binding]; other site 760192006112 Helix-turn-helix; Region: HTH_3; pfam01381 760192006113 non-specific DNA binding site [nucleotide binding]; other site 760192006114 salt bridge; other site 760192006115 sequence-specific DNA binding site [nucleotide binding]; other site 760192006116 AIPR protein; Region: AIPR; pfam10592 760192006117 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 760192006118 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 760192006119 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 760192006120 Z1 domain; Region: Z1; pfam10593 760192006121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192006122 ATP binding site [chemical binding]; other site 760192006123 Mg2+ binding site [ion binding]; other site 760192006124 G-X-G motif; other site 760192006125 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 760192006126 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 760192006127 cofactor binding site; other site 760192006128 DNA binding site [nucleotide binding] 760192006129 substrate interaction site [chemical binding]; other site 760192006130 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 760192006131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192006132 non-specific DNA binding site [nucleotide binding]; other site 760192006133 salt bridge; other site 760192006134 sequence-specific DNA binding site [nucleotide binding]; other site 760192006135 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 760192006136 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192006137 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192006138 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192006139 DinB superfamily; Region: DinB_2; pfam12867 760192006140 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 760192006141 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 760192006142 Response regulator receiver domain; Region: Response_reg; pfam00072 760192006143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192006144 active site 760192006145 phosphorylation site [posttranslational modification] 760192006146 intermolecular recognition site; other site 760192006147 dimerization interface [polypeptide binding]; other site 760192006148 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 760192006149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192006150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192006151 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192006152 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192006153 ligand binding site [chemical binding]; other site 760192006154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192006155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192006156 ATP binding site [chemical binding]; other site 760192006157 Mg2+ binding site [ion binding]; other site 760192006158 G-X-G motif; other site 760192006159 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 760192006160 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 760192006161 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 760192006162 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 760192006163 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192006164 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192006165 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192006166 ligand binding site [chemical binding]; other site 760192006167 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 760192006168 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760192006169 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760192006170 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 760192006171 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 760192006172 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 760192006173 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 760192006174 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 760192006175 conserved hypothetical protein; Region: MJ1255; TIGR00661 760192006176 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192006177 ESAG protein; Region: ESAG1; cl03953 760192006178 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 760192006179 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 760192006180 homodimer interface [polypeptide binding]; other site 760192006181 oligonucleotide binding site [chemical binding]; other site 760192006182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192006183 binding surface 760192006184 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 760192006185 IHF - DNA interface [nucleotide binding]; other site 760192006186 IHF dimer interface [polypeptide binding]; other site 760192006187 hypothetical protein; Provisional; Region: PRK11820 760192006188 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 760192006189 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 760192006190 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 760192006191 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 760192006192 catalytic site [active] 760192006193 G-X2-G-X-G-K; other site 760192006194 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 760192006195 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 760192006196 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192006197 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192006198 catalytic residues [active] 760192006199 Surface antigen; Region: Bac_surface_Ag; pfam01103 760192006200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192006201 metabolite-proton symporter; Region: 2A0106; TIGR00883 760192006202 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 760192006203 four helix bundle protein; Region: TIGR02436 760192006204 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 760192006205 HemN C-terminal domain; Region: HemN_C; pfam06969 760192006206 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192006207 Ligand Binding Site [chemical binding]; other site 760192006208 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192006209 Ligand Binding Site [chemical binding]; other site 760192006210 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 760192006211 Fatty acid desaturase; Region: FA_desaturase; pfam00487 760192006212 putative di-iron ligands [ion binding]; other site 760192006213 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 760192006214 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 760192006215 dimer interface [polypeptide binding]; other site 760192006216 active site 760192006217 CoA binding pocket [chemical binding]; other site 760192006218 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 760192006219 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192006220 Surface antigen; Region: Bac_surface_Ag; pfam01103 760192006221 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 760192006222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192006223 AAA domain; Region: AAA_21; pfam13304 760192006224 Walker A/P-loop; other site 760192006225 ATP binding site [chemical binding]; other site 760192006226 Predicted acetyltransferase [General function prediction only]; Region: COG2388 760192006227 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 760192006228 Na binding site [ion binding]; other site 760192006229 putative glycosylation site [posttranslational modification]; other site 760192006230 putative glycosylation site [posttranslational modification]; other site 760192006231 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 760192006232 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 760192006233 active site 760192006234 dimer interface [polypeptide binding]; other site 760192006235 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 760192006236 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 760192006237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192006238 Walker A motif; other site 760192006239 ATP binding site [chemical binding]; other site 760192006240 Walker B motif; other site 760192006241 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 760192006242 GxxExxY protein; Region: GxxExxY; TIGR04256 760192006243 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192006244 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192006245 RNA ligase; Region: RNA_ligase; pfam09414 760192006246 AAA domain; Region: AAA_33; pfam13671 760192006247 fructokinase; Reviewed; Region: PRK09557 760192006248 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760192006249 nucleotide binding site [chemical binding]; other site 760192006250 multifunctional aminopeptidase A; Provisional; Region: PRK00913 760192006251 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 760192006252 interface (dimer of trimers) [polypeptide binding]; other site 760192006253 Substrate-binding/catalytic site; other site 760192006254 Zn-binding sites [ion binding]; other site 760192006255 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192006256 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 760192006257 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192006258 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192006259 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192006260 Phytase; Region: Phytase; cl17685 760192006261 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 760192006262 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 760192006263 dimer interface [polypeptide binding]; other site 760192006264 ADP-ribose binding site [chemical binding]; other site 760192006265 active site 760192006266 nudix motif; other site 760192006267 metal binding site [ion binding]; metal-binding site 760192006268 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 760192006269 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 760192006270 hinge; other site 760192006271 active site 760192006272 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 760192006273 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 760192006274 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 760192006275 glutaminase active site [active] 760192006276 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 760192006277 dimer interface [polypeptide binding]; other site 760192006278 active site 760192006279 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 760192006280 dimer interface [polypeptide binding]; other site 760192006281 active site 760192006282 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 760192006283 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 760192006284 Pantoate-beta-alanine ligase; Region: PanC; cd00560 760192006285 pantoate--beta-alanine ligase; Region: panC; TIGR00018 760192006286 active site 760192006287 ATP-binding site [chemical binding]; other site 760192006288 pantoate-binding site; other site 760192006289 HXXH motif; other site 760192006290 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 760192006291 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 760192006292 CAP-like domain; other site 760192006293 active site 760192006294 primary dimer interface [polypeptide binding]; other site 760192006295 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 760192006296 tetramer interface [polypeptide binding]; other site 760192006297 serine racemase; Region: PLN02970 760192006298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192006299 catalytic residue [active] 760192006300 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192006301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192006302 TPR motif; other site 760192006303 Tetratricopeptide repeat; Region: TPR_16; pfam13432 760192006304 binding surface 760192006305 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192006306 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192006307 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 760192006308 putative active site [active] 760192006309 Zn binding site [ion binding]; other site 760192006310 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 760192006311 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 760192006312 FAD binding site [chemical binding]; other site 760192006313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192006314 S-adenosylmethionine binding site [chemical binding]; other site 760192006315 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192006316 active site 760192006317 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 760192006318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192006319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192006320 ATP binding site [chemical binding]; other site 760192006321 Mg2+ binding site [ion binding]; other site 760192006322 G-X-G motif; other site 760192006323 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 760192006324 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 760192006325 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760192006326 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 760192006327 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 760192006328 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 760192006329 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 760192006330 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 760192006331 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 760192006332 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 760192006333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 760192006334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192006335 Coenzyme A binding pocket [chemical binding]; other site 760192006336 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 760192006337 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 760192006338 active site 760192006339 intersubunit interface [polypeptide binding]; other site 760192006340 Zn2+ binding site [ion binding]; other site 760192006341 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 760192006342 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 760192006343 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760192006344 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760192006345 DNA binding site [nucleotide binding] 760192006346 domain linker motif; other site 760192006347 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760192006348 dimerization interface [polypeptide binding]; other site 760192006349 ligand binding site [chemical binding]; other site 760192006350 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192006351 Beta-lactamase; Region: Beta-lactamase; cl17358 760192006352 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 760192006353 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 760192006354 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 760192006355 active site 760192006356 C-N hydrolase family amidase; Provisional; Region: PRK10438 760192006357 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 760192006358 putative active site [active] 760192006359 catalytic triad [active] 760192006360 dimer interface [polypeptide binding]; other site 760192006361 multimer interface [polypeptide binding]; other site 760192006362 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192006363 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 760192006364 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 760192006365 putative NAD(P) binding site [chemical binding]; other site 760192006366 homodimer interface [polypeptide binding]; other site 760192006367 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760192006368 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192006369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192006370 Glycosyl hydrolase family 43; Region: GH43_3; cd08982 760192006371 active site 760192006372 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 760192006373 sugar binding site [chemical binding]; other site 760192006374 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 760192006375 Interdomain contacts; other site 760192006376 Cytokine receptor motif; other site 760192006377 Predicted amidohydrolase [General function prediction only]; Region: COG0388 760192006378 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 760192006379 putative active site [active] 760192006380 catalytic triad [active] 760192006381 putative dimer interface [polypeptide binding]; other site 760192006382 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 760192006383 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 760192006384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192006385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192006386 DNA binding residues [nucleotide binding] 760192006387 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192006388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192006389 active site 760192006390 phosphorylation site [posttranslational modification] 760192006391 intermolecular recognition site; other site 760192006392 dimerization interface [polypeptide binding]; other site 760192006393 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192006394 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192006395 ligand binding site [chemical binding]; other site 760192006396 flexible hinge region; other site 760192006397 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760192006398 putative switch regulator; other site 760192006399 non-specific DNA interactions [nucleotide binding]; other site 760192006400 DNA binding site [nucleotide binding] 760192006401 sequence specific DNA binding site [nucleotide binding]; other site 760192006402 putative cAMP binding site [chemical binding]; other site 760192006403 PAS domain; Region: PAS_9; pfam13426 760192006404 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192006405 putative active site [active] 760192006406 heme pocket [chemical binding]; other site 760192006407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192006408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192006409 dimer interface [polypeptide binding]; other site 760192006410 phosphorylation site [posttranslational modification] 760192006411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192006412 ATP binding site [chemical binding]; other site 760192006413 Mg2+ binding site [ion binding]; other site 760192006414 G-X-G motif; other site 760192006415 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 760192006416 FOG: CBS domain [General function prediction only]; Region: COG0517 760192006417 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 760192006418 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 760192006419 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192006420 putative catalytic residue [active] 760192006421 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192006422 short chain dehydrogenase; Provisional; Region: PRK08339 760192006423 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 760192006424 putative NAD(P) binding site [chemical binding]; other site 760192006425 putative active site [active] 760192006426 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 760192006427 putative active site [active] 760192006428 putative metal binding site [ion binding]; other site 760192006429 Cytochrome c; Region: Cytochrom_C; pfam00034 760192006430 Cytochrome c; Region: Cytochrom_C; pfam00034 760192006431 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 760192006432 Part of AAA domain; Region: AAA_19; pfam13245 760192006433 Family description; Region: UvrD_C_2; pfam13538 760192006434 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 760192006435 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 760192006436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192006437 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192006438 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 760192006439 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 760192006440 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 760192006441 DNA binding site [nucleotide binding] 760192006442 active site 760192006443 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 760192006444 MoxR-like ATPases [General function prediction only]; Region: COG0714 760192006445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192006446 Walker A motif; other site 760192006447 ATP binding site [chemical binding]; other site 760192006448 Walker B motif; other site 760192006449 arginine finger; other site 760192006450 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 760192006451 Protein of unknown function DUF58; Region: DUF58; pfam01882 760192006452 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 760192006453 metal ion-dependent adhesion site (MIDAS); other site 760192006454 hypothetical protein; Provisional; Region: PRK13685 760192006455 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 760192006456 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 760192006457 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 760192006458 metal ion-dependent adhesion site (MIDAS); other site 760192006459 TPR repeat; Region: TPR_11; pfam13414 760192006460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192006461 binding surface 760192006462 TPR motif; other site 760192006463 TPR repeat; Region: TPR_11; pfam13414 760192006464 Oxygen tolerance; Region: BatD; pfam13584 760192006465 Oxygen tolerance; Region: BatD; pfam13584 760192006466 SCP-2 sterol transfer family; Region: SCP2; pfam02036 760192006467 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192006468 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 760192006469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 760192006470 ACT domain; Region: ACT_3; pfam10000 760192006471 Family description; Region: ACT_7; pfam13840 760192006472 Galactose oxidase, central domain; Region: Kelch_3; cl02701 760192006473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192006474 binding surface 760192006475 TPR motif; other site 760192006476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192006477 binding surface 760192006478 TPR motif; other site 760192006479 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192006480 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 760192006481 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 760192006482 dimerization interface [polypeptide binding]; other site 760192006483 active site 760192006484 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 760192006485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192006486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192006487 DNA binding residues [nucleotide binding] 760192006488 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 760192006489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192006490 FeS/SAM binding site; other site 760192006491 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 760192006492 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 760192006493 substrate binding pocket [chemical binding]; other site 760192006494 chain length determination region; other site 760192006495 substrate-Mg2+ binding site; other site 760192006496 catalytic residues [active] 760192006497 aspartate-rich region 1; other site 760192006498 active site lid residues [active] 760192006499 aspartate-rich region 2; other site 760192006500 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 760192006501 active site 760192006502 metal binding site [ion binding]; metal-binding site 760192006503 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192006504 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 760192006505 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 760192006506 dimer interface [polypeptide binding]; other site 760192006507 active site 760192006508 glycine-pyridoxal phosphate binding site [chemical binding]; other site 760192006509 folate binding site [chemical binding]; other site 760192006510 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 760192006511 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 760192006512 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192006513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192006514 binding surface 760192006515 TPR motif; other site 760192006516 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192006517 CHAT domain; Region: CHAT; pfam12770 760192006518 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 760192006519 active site 760192006520 catalytic triad [active] 760192006521 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192006522 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 760192006523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760192006524 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 760192006525 Flavoprotein; Region: Flavoprotein; pfam02441 760192006526 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 760192006527 Outer membrane lipoprotein; Region: YfiO; pfam13525 760192006528 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 760192006529 23S rRNA interface [nucleotide binding]; other site 760192006530 L3 interface [polypeptide binding]; other site 760192006531 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 760192006532 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 760192006533 rRNA interaction site [nucleotide binding]; other site 760192006534 S8 interaction site; other site 760192006535 putative laminin-1 binding site; other site 760192006536 elongation factor Ts; Provisional; Region: tsf; PRK09377 760192006537 UBA/TS-N domain; Region: UBA; pfam00627 760192006538 Elongation factor TS; Region: EF_TS; pfam00889 760192006539 Elongation factor TS; Region: EF_TS; pfam00889 760192006540 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 760192006541 putative nucleotide binding site [chemical binding]; other site 760192006542 uridine monophosphate binding site [chemical binding]; other site 760192006543 homohexameric interface [polypeptide binding]; other site 760192006544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192006545 non-specific DNA binding site [nucleotide binding]; other site 760192006546 salt bridge; other site 760192006547 sequence-specific DNA binding site [nucleotide binding]; other site 760192006548 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 760192006549 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 760192006550 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 760192006551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192006552 ATP binding site [chemical binding]; other site 760192006553 Mg2+ binding site [ion binding]; other site 760192006554 G-X-G motif; other site 760192006555 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 760192006556 anchoring element; other site 760192006557 dimer interface [polypeptide binding]; other site 760192006558 ATP binding site [chemical binding]; other site 760192006559 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 760192006560 active site 760192006561 putative metal-binding site [ion binding]; other site 760192006562 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 760192006563 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 760192006564 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 760192006565 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 760192006566 hexamer interface [polypeptide binding]; other site 760192006567 ligand binding site [chemical binding]; other site 760192006568 putative active site [active] 760192006569 NAD(P) binding site [chemical binding]; other site 760192006570 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192006571 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192006572 ligand binding site [chemical binding]; other site 760192006573 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 760192006574 Immunoglobulin domain; Region: Ig; cl11960 760192006575 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192006576 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 760192006577 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 760192006578 HIGH motif; other site 760192006579 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 760192006580 active site 760192006581 KMSKS motif; other site 760192006582 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 760192006583 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 760192006584 NodB motif; other site 760192006585 active site 760192006586 catalytic site [active] 760192006587 metal binding site [ion binding]; metal-binding site 760192006588 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 760192006589 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 760192006590 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 760192006591 FeoA domain; Region: FeoA; pfam04023 760192006592 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192006593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192006594 active site 760192006595 phosphorylation site [posttranslational modification] 760192006596 intermolecular recognition site; other site 760192006597 dimerization interface [polypeptide binding]; other site 760192006598 LytTr DNA-binding domain; Region: LytTR; smart00850 760192006599 carboxy-terminal protease; Provisional; Region: PRK11186 760192006600 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760192006601 protein binding site [polypeptide binding]; other site 760192006602 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 760192006603 Catalytic dyad [active] 760192006604 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 760192006605 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 760192006606 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192006607 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192006608 ScpA/B protein; Region: ScpA_ScpB; cl00598 760192006609 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 760192006610 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 760192006611 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192006612 inhibitor-cofactor binding pocket; inhibition site 760192006613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192006614 catalytic residue [active] 760192006615 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 760192006616 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 760192006617 active site 760192006618 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192006619 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 760192006620 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 760192006621 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192006622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192006623 Walker A motif; other site 760192006624 ATP binding site [chemical binding]; other site 760192006625 Walker B motif; other site 760192006626 arginine finger; other site 760192006627 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 760192006628 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 760192006629 putative trimer interface [polypeptide binding]; other site 760192006630 putative active site [active] 760192006631 putative substrate binding site [chemical binding]; other site 760192006632 putative CoA binding site [chemical binding]; other site 760192006633 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192006634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192006635 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192006636 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 760192006637 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192006638 hypothetical protein; Reviewed; Region: PRK00024 760192006639 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 760192006640 MPN+ (JAMM) motif; other site 760192006641 Zinc-binding site [ion binding]; other site 760192006642 ribonuclease P; Reviewed; Region: rnpA; PRK01903 760192006643 Protoglobin; Region: Protoglobin; pfam11563 760192006644 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 760192006645 Transcriptional regulators [Transcription]; Region: MarR; COG1846 760192006646 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 760192006647 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 760192006648 Dehydroquinase class II; Region: DHquinase_II; pfam01220 760192006649 active site 760192006650 trimer interface [polypeptide binding]; other site 760192006651 dimer interface [polypeptide binding]; other site 760192006652 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 760192006653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192006654 ATP binding site [chemical binding]; other site 760192006655 putative Mg++ binding site [ion binding]; other site 760192006656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192006657 nucleotide binding region [chemical binding]; other site 760192006658 ATP-binding site [chemical binding]; other site 760192006659 RQC domain; Region: RQC; pfam09382 760192006660 HRDC domain; Region: HRDC; pfam00570 760192006661 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 760192006662 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 760192006663 putative active site [active] 760192006664 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 760192006665 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 760192006666 homodimer interface [polypeptide binding]; other site 760192006667 metal binding site [ion binding]; metal-binding site 760192006668 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 760192006669 putative active site [active] 760192006670 dimerization interface [polypeptide binding]; other site 760192006671 putative tRNAtyr binding site [nucleotide binding]; other site 760192006672 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 760192006673 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192006674 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 760192006675 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 760192006676 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 760192006677 glutamyl-tRNA reductase; Region: hemA; TIGR01035 760192006678 tRNA; other site 760192006679 putative tRNA binding site [nucleotide binding]; other site 760192006680 putative NADP binding site [chemical binding]; other site 760192006681 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 760192006682 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 760192006683 dimer interface [polypeptide binding]; other site 760192006684 anticodon binding site; other site 760192006685 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 760192006686 homodimer interface [polypeptide binding]; other site 760192006687 motif 1; other site 760192006688 active site 760192006689 motif 2; other site 760192006690 GAD domain; Region: GAD; pfam02938 760192006691 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 760192006692 active site 760192006693 motif 3; other site 760192006694 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 760192006695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192006696 TPR repeat; Region: TPR_11; pfam13414 760192006697 binding surface 760192006698 TPR motif; other site 760192006699 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 760192006700 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 760192006701 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 760192006702 prolyl-tRNA synthetase; Provisional; Region: PRK08661 760192006703 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 760192006704 dimer interface [polypeptide binding]; other site 760192006705 motif 1; other site 760192006706 active site 760192006707 motif 2; other site 760192006708 motif 3; other site 760192006709 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 760192006710 anticodon binding site; other site 760192006711 zinc-binding site [ion binding]; other site 760192006712 HipA N-terminal domain; Region: Couple_hipA; cl11853 760192006713 Protein of unknown function (DUF433); Region: DUF433; cl01030 760192006714 DEAD-like helicases superfamily; Region: DEXDc; smart00487 760192006715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192006716 ATP binding site [chemical binding]; other site 760192006717 putative Mg++ binding site [ion binding]; other site 760192006718 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 760192006719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192006720 nucleotide binding region [chemical binding]; other site 760192006721 ATP-binding site [chemical binding]; other site 760192006722 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 760192006723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192006724 ATP binding site [chemical binding]; other site 760192006725 putative Mg++ binding site [ion binding]; other site 760192006726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192006727 ATP-binding site [chemical binding]; other site 760192006728 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 760192006729 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 760192006730 putative active site [active] 760192006731 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192006732 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192006733 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 760192006734 TraB family; Region: TraB; pfam01963 760192006735 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192006736 Ligand Binding Site [chemical binding]; other site 760192006737 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192006738 Ligand Binding Site [chemical binding]; other site 760192006739 META domain; Region: META; pfam03724 760192006740 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 760192006741 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 760192006742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192006743 Walker A motif; other site 760192006744 ATP binding site [chemical binding]; other site 760192006745 Walker B motif; other site 760192006746 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 760192006747 Clp protease; Region: CLP_protease; pfam00574 760192006748 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 760192006749 oligomer interface [polypeptide binding]; other site 760192006750 active site residues [active] 760192006751 trigger factor; Region: tig; TIGR00115 760192006752 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 760192006753 metal binding site 2 [ion binding]; metal-binding site 760192006754 putative DNA binding helix; other site 760192006755 metal binding site 1 [ion binding]; metal-binding site 760192006756 dimer interface [polypeptide binding]; other site 760192006757 structural Zn2+ binding site [ion binding]; other site 760192006758 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 760192006759 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 760192006760 GDP-binding site [chemical binding]; other site 760192006761 ACT binding site; other site 760192006762 IMP binding site; other site 760192006763 6-phosphofructokinase; Provisional; Region: PRK03202 760192006764 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 760192006765 active site 760192006766 ADP/pyrophosphate binding site [chemical binding]; other site 760192006767 dimerization interface [polypeptide binding]; other site 760192006768 allosteric effector site; other site 760192006769 fructose-1,6-bisphosphate binding site; other site 760192006770 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 760192006771 CoA binding domain; Region: CoA_binding_2; pfam13380 760192006772 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 760192006773 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 760192006774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760192006775 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760192006776 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 760192006777 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 760192006778 homotrimer interaction site [polypeptide binding]; other site 760192006779 putative active site [active] 760192006780 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192006781 active site 760192006782 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 760192006783 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 760192006784 YARHG domain; Region: YARHG; pfam13308 760192006785 Winged helix-turn helix; Region: HTH_29; pfam13551 760192006786 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192006787 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 760192006788 Divergent AAA domain; Region: AAA_4; pfam04326 760192006789 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 760192006790 HTH domain; Region: HTH_11; pfam08279 760192006791 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 760192006792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192006793 catalytic loop [active] 760192006794 iron binding site [ion binding]; other site 760192006795 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 760192006796 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 760192006797 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 760192006798 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192006799 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 760192006800 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 760192006801 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 760192006802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192006803 Zn binding site [ion binding]; other site 760192006804 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 760192006805 Zn binding site [ion binding]; other site 760192006806 putative hydrolase; Provisional; Region: PRK11460 760192006807 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 760192006808 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 760192006809 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 760192006810 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 760192006811 active site 760192006812 catalytic site [active] 760192006813 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 760192006814 putative ligand binding site [chemical binding]; other site 760192006815 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192006816 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192006817 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 760192006818 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 760192006819 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192006820 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192006821 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 760192006822 Protein export membrane protein; Region: SecD_SecF; cl14618 760192006823 Outer membrane efflux protein; Region: OEP; pfam02321 760192006824 Outer membrane efflux protein; Region: OEP; pfam02321 760192006825 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 760192006826 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 760192006827 putative tRNA-binding site [nucleotide binding]; other site 760192006828 B3/4 domain; Region: B3_4; pfam03483 760192006829 tRNA synthetase B5 domain; Region: B5; pfam03484 760192006830 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 760192006831 motif 1; other site 760192006832 dimer interface [polypeptide binding]; other site 760192006833 active site 760192006834 motif 2; other site 760192006835 motif 3; other site 760192006836 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 760192006837 Cell division protein ZapA; Region: ZapA; pfam05164 760192006838 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 760192006839 phosphodiesterase; Provisional; Region: PRK12704 760192006840 KH domain; Region: KH_1; pfam00013 760192006841 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760192006842 Zn2+ binding site [ion binding]; other site 760192006843 Mg2+ binding site [ion binding]; other site 760192006844 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 760192006845 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192006846 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192006847 ligand binding site [chemical binding]; other site 760192006848 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192006849 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 760192006850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192006851 putative DNA binding site [nucleotide binding]; other site 760192006852 putative Zn2+ binding site [ion binding]; other site 760192006853 AsnC family; Region: AsnC_trans_reg; pfam01037 760192006854 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 760192006855 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192006856 inhibitor-cofactor binding pocket; inhibition site 760192006857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192006858 catalytic residue [active] 760192006859 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 760192006860 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192006861 putative active site [active] 760192006862 putative NTP binding site [chemical binding]; other site 760192006863 putative nucleic acid binding site [nucleotide binding]; other site 760192006864 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 760192006865 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 760192006866 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 760192006867 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 760192006868 XisH protein; Region: XisH; pfam08814 760192006869 XisI protein; Region: XisI; pfam08869 760192006870 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 760192006871 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 760192006872 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 760192006873 DNA binding site [nucleotide binding] 760192006874 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 760192006875 XisI protein; Region: XisI; pfam08869 760192006876 XisH protein; Region: XisH; pfam08814 760192006877 XisI protein; Region: XisI; pfam08869 760192006878 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 760192006879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192006880 Walker A/P-loop; other site 760192006881 ATP binding site [chemical binding]; other site 760192006882 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 760192006883 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 760192006884 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 760192006885 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 760192006886 Walker A/P-loop; other site 760192006887 ATP binding site [chemical binding]; other site 760192006888 Q-loop/lid; other site 760192006889 ABC transporter signature motif; other site 760192006890 Walker B; other site 760192006891 D-loop; other site 760192006892 H-loop/switch region; other site 760192006893 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 760192006894 putative carbohydrate binding site [chemical binding]; other site 760192006895 sulfotransferase; Region: PLN02164 760192006896 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 760192006897 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 760192006898 trimer interface [polypeptide binding]; other site 760192006899 active site 760192006900 substrate binding site [chemical binding]; other site 760192006901 CoA binding site [chemical binding]; other site 760192006902 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 760192006903 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 760192006904 metal-binding site 760192006905 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760192006906 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 760192006907 active site 760192006908 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192006909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192006910 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192006911 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192006912 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 760192006913 putative ADP-binding pocket [chemical binding]; other site 760192006914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192006915 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192006916 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192006917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192006918 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192006919 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 760192006920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192006921 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 760192006922 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 760192006923 active site 760192006924 catalytic triad [active] 760192006925 oxyanion hole [active] 760192006926 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 760192006927 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192006928 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192006929 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192006930 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192006931 catalytic tetrad [active] 760192006932 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192006933 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192006934 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 760192006935 putative metal binding site; other site 760192006936 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 760192006937 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 760192006938 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 760192006939 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 760192006940 active site 760192006941 dimer interface [polypeptide binding]; other site 760192006942 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 760192006943 Ligand Binding Site [chemical binding]; other site 760192006944 Molecular Tunnel; other site 760192006945 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 760192006946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192006947 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 760192006948 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 760192006949 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760192006950 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 760192006951 metal-binding site 760192006952 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760192006953 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 760192006954 metal-binding site 760192006955 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 760192006956 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 760192006957 NADP-binding site; other site 760192006958 homotetramer interface [polypeptide binding]; other site 760192006959 substrate binding site [chemical binding]; other site 760192006960 homodimer interface [polypeptide binding]; other site 760192006961 active site 760192006962 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 760192006963 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 760192006964 NADP binding site [chemical binding]; other site 760192006965 active site 760192006966 putative substrate binding site [chemical binding]; other site 760192006967 putative transposase OrfB; Reviewed; Region: PHA02517 760192006968 Integrase core domain; Region: rve; pfam00665 760192006969 Integrase core domain; Region: rve_3; pfam13683 760192006970 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 760192006971 glutamate formiminotransferase; Region: FtcD; TIGR02024 760192006972 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 760192006973 Formiminotransferase domain; Region: FTCD; pfam02971 760192006974 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 760192006975 intersubunit interface [polypeptide binding]; other site 760192006976 active site 760192006977 catalytic residue [active] 760192006978 Sporulation related domain; Region: SPOR; pfam05036 760192006979 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 760192006980 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 760192006981 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 760192006982 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 760192006983 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 760192006984 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 760192006985 DNA binding residues [nucleotide binding] 760192006986 B12 binding domain; Region: B12-binding_2; pfam02607 760192006987 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192006988 proline aminopeptidase P II; Provisional; Region: PRK10879 760192006989 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 760192006990 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 760192006991 active site 760192006992 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 760192006993 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 760192006994 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 760192006995 trmE is a tRNA modification GTPase; Region: trmE; cd04164 760192006996 G1 box; other site 760192006997 GTP/Mg2+ binding site [chemical binding]; other site 760192006998 Switch I region; other site 760192006999 G2 box; other site 760192007000 Switch II region; other site 760192007001 G3 box; other site 760192007002 G4 box; other site 760192007003 G5 box; other site 760192007004 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 760192007005 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 760192007006 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 760192007007 active site 760192007008 Zn binding site [ion binding]; other site 760192007009 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192007010 Ligand Binding Site [chemical binding]; other site 760192007011 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192007012 Ligand Binding Site [chemical binding]; other site 760192007013 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 760192007014 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 760192007015 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192007016 thiamine-monophosphate kinase; Region: thiL; TIGR01379 760192007017 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 760192007018 ATP binding site [chemical binding]; other site 760192007019 dimerization interface [polypeptide binding]; other site 760192007020 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760192007021 catalytic residues [active] 760192007022 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 760192007023 DDE superfamily endonuclease; Region: DDE_5; cl17874 760192007024 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 760192007025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 760192007026 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 760192007027 dimer interface [polypeptide binding]; other site 760192007028 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 760192007029 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192007030 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 760192007031 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 760192007032 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 760192007033 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 760192007034 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 760192007035 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192007036 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192007037 catalytic residues [active] 760192007038 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 760192007039 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192007040 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760192007041 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192007042 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 760192007043 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 760192007044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192007045 catalytic residue [active] 760192007046 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192007047 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192007048 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192007049 DNA binding residues [nucleotide binding] 760192007050 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760192007051 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 760192007052 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 760192007053 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 760192007054 active site 760192007055 M28 Zn-Peptidases; Region: M28_like_6; cd08656 760192007056 Peptidase family M28; Region: Peptidase_M28; pfam04389 760192007057 metal binding site [ion binding]; metal-binding site 760192007058 Predicted methyltransferases [General function prediction only]; Region: COG0313 760192007059 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 760192007060 putative SAM binding site [chemical binding]; other site 760192007061 putative homodimer interface [polypeptide binding]; other site 760192007062 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 760192007063 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 760192007064 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 760192007065 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 760192007066 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192007067 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192007068 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192007069 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192007070 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 760192007071 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192007072 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192007073 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192007074 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 760192007075 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 760192007076 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192007077 GH3 auxin-responsive promoter; Region: GH3; pfam03321 760192007078 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 760192007079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 760192007080 active site 760192007081 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 760192007082 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 760192007083 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 760192007084 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 760192007085 dimer interface [polypeptide binding]; other site 760192007086 ssDNA binding site [nucleotide binding]; other site 760192007087 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760192007088 GTPase CgtA; Reviewed; Region: obgE; PRK12299 760192007089 GTP1/OBG; Region: GTP1_OBG; pfam01018 760192007090 Obg GTPase; Region: Obg; cd01898 760192007091 G1 box; other site 760192007092 GTP/Mg2+ binding site [chemical binding]; other site 760192007093 Switch I region; other site 760192007094 G2 box; other site 760192007095 G3 box; other site 760192007096 Switch II region; other site 760192007097 G4 box; other site 760192007098 G5 box; other site 760192007099 adenylate kinase; Reviewed; Region: adk; PRK00279 760192007100 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 760192007101 AMP-binding site [chemical binding]; other site 760192007102 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 760192007103 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 760192007104 NlpC/P60 family; Region: NLPC_P60; pfam00877 760192007105 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 760192007106 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 760192007107 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 760192007108 trimer interface [polypeptide binding]; other site 760192007109 active site 760192007110 substrate binding site [chemical binding]; other site 760192007111 CoA binding site [chemical binding]; other site 760192007112 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 760192007113 putative active site [active] 760192007114 catalytic residue [active] 760192007115 FOG: CBS domain [General function prediction only]; Region: COG0517 760192007116 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 760192007117 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 760192007118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192007119 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 760192007120 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 760192007121 CysD dimerization site [polypeptide binding]; other site 760192007122 G1 box; other site 760192007123 putative GEF interaction site [polypeptide binding]; other site 760192007124 GTP/Mg2+ binding site [chemical binding]; other site 760192007125 Switch I region; other site 760192007126 G2 box; other site 760192007127 G3 box; other site 760192007128 Switch II region; other site 760192007129 G4 box; other site 760192007130 G5 box; other site 760192007131 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 760192007132 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 760192007133 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 760192007134 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 760192007135 Active Sites [active] 760192007136 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 760192007137 ligand-binding site [chemical binding]; other site 760192007138 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 760192007139 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 760192007140 catalytic triad [active] 760192007141 putative active site [active] 760192007142 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192007143 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 760192007144 metal-binding site [ion binding] 760192007145 CotH protein; Region: CotH; pfam08757 760192007146 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192007147 Two component regulator propeller; Region: Reg_prop; pfam07494 760192007148 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192007149 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192007150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192007151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192007152 dimer interface [polypeptide binding]; other site 760192007153 phosphorylation site [posttranslational modification] 760192007154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192007155 ATP binding site [chemical binding]; other site 760192007156 Mg2+ binding site [ion binding]; other site 760192007157 G-X-G motif; other site 760192007158 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192007159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192007160 active site 760192007161 phosphorylation site [posttranslational modification] 760192007162 intermolecular recognition site; other site 760192007163 dimerization interface [polypeptide binding]; other site 760192007164 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 760192007165 cyclase homology domain; Region: CHD; cd07302 760192007166 nucleotidyl binding site; other site 760192007167 metal binding site [ion binding]; metal-binding site 760192007168 dimer interface [polypeptide binding]; other site 760192007169 Leucine rich repeat; Region: LRR_8; pfam13855 760192007170 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 760192007171 Leucine-rich repeats; other site 760192007172 Substrate binding site [chemical binding]; other site 760192007173 Leucine rich repeat; Region: LRR_8; pfam13855 760192007174 Leucine rich repeat; Region: LRR_8; pfam13855 760192007175 Leucine rich repeat; Region: LRR_8; pfam13855 760192007176 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 760192007177 conserved hypothetical protein; Region: TIGR02231 760192007178 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 760192007179 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 760192007180 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 760192007181 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 760192007182 putative active site [active] 760192007183 putative metal binding site [ion binding]; other site 760192007184 imidazolonepropionase; Validated; Region: PRK09356 760192007185 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 760192007186 active site 760192007187 urocanate hydratase; Provisional; Region: PRK05414 760192007188 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 760192007189 active sites [active] 760192007190 tetramer interface [polypeptide binding]; other site 760192007191 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 760192007192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760192007193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 760192007194 dimerization interface [polypeptide binding]; other site 760192007195 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 760192007196 serpin-like protein; Provisional; Region: PHA02660 760192007197 reactive center loop; other site 760192007198 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 760192007199 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 760192007200 putative catalytic residues [active] 760192007201 nucleotide binding site [chemical binding]; other site 760192007202 aspartate binding site [chemical binding]; other site 760192007203 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 760192007204 dimer interface [polypeptide binding]; other site 760192007205 putative threonine allosteric regulatory site; other site 760192007206 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 760192007207 putative threonine allosteric regulatory site; other site 760192007208 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 760192007209 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 760192007210 homoserine kinase; Provisional; Region: PRK01212 760192007211 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 760192007212 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 760192007213 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 760192007214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192007215 catalytic residue [active] 760192007216 Transposase IS200 like; Region: Y1_Tnp; pfam01797 760192007217 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 760192007218 Zn binding site [ion binding]; other site 760192007219 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 760192007220 putative hydrophobic ligand binding site [chemical binding]; other site 760192007221 diphosphomevalonate decarboxylase; Region: PLN02407 760192007222 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 760192007223 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 760192007224 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192007225 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192007226 catalytic residue [active] 760192007227 Fic family protein [Function unknown]; Region: COG3177 760192007228 Fic/DOC family; Region: Fic; pfam02661 760192007229 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 760192007230 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 760192007231 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 760192007232 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 760192007233 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 760192007234 Peptidase family M23; Region: Peptidase_M23; pfam01551 760192007235 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 760192007236 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192007237 catalytic triad [active] 760192007238 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 760192007239 hypothetical protein; Provisional; Region: PRK06849 760192007240 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192007241 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 760192007242 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 760192007243 domain interfaces; other site 760192007244 active site 760192007245 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 760192007246 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 760192007247 active site 760192007248 Substrate binding site; other site 760192007249 Mg++ binding site; other site 760192007250 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 760192007251 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 760192007252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007253 binding surface 760192007254 TPR motif; other site 760192007255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007256 binding surface 760192007257 TPR motif; other site 760192007258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007259 TPR motif; other site 760192007260 binding surface 760192007261 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 760192007262 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 760192007263 Peptidase family M23; Region: Peptidase_M23; pfam01551 760192007264 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 760192007265 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 760192007266 HflX GTPase family; Region: HflX; cd01878 760192007267 G1 box; other site 760192007268 GTP/Mg2+ binding site [chemical binding]; other site 760192007269 Switch I region; other site 760192007270 G2 box; other site 760192007271 G3 box; other site 760192007272 Switch II region; other site 760192007273 G4 box; other site 760192007274 G5 box; other site 760192007275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760192007276 active site 760192007277 Phosphotransferase enzyme family; Region: APH; pfam01636 760192007278 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 760192007279 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 760192007280 active site 760192007281 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192007282 Transposase [DNA replication, recombination, and repair]; Region: COG5421 760192007283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192007284 TPR motif; other site 760192007285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007286 TPR motif; other site 760192007287 binding surface 760192007288 TPR repeat; Region: TPR_11; pfam13414 760192007289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007290 binding surface 760192007291 TPR motif; other site 760192007292 TPR repeat; Region: TPR_11; pfam13414 760192007293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007294 binding surface 760192007295 TPR motif; other site 760192007296 TPR repeat; Region: TPR_11; pfam13414 760192007297 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192007298 EamA-like transporter family; Region: EamA; pfam00892 760192007299 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 760192007300 EamA-like transporter family; Region: EamA; pfam00892 760192007301 acyl-CoA esterase; Provisional; Region: PRK10673 760192007302 PGAP1-like protein; Region: PGAP1; pfam07819 760192007303 GxxExxY protein; Region: GxxExxY; TIGR04256 760192007304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007305 binding surface 760192007306 TPR motif; other site 760192007307 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192007308 CHAT domain; Region: CHAT; pfam12770 760192007309 cyclase homology domain; Region: CHD; cd07302 760192007310 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 760192007311 nucleotidyl binding site; other site 760192007312 metal binding site [ion binding]; metal-binding site 760192007313 dimer interface [polypeptide binding]; other site 760192007314 cyclase homology domain; Region: CHD; cd07302 760192007315 dimer interface [polypeptide binding]; other site 760192007316 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 760192007317 nucleotidyl binding site; other site 760192007318 metal binding site [ion binding]; metal-binding site 760192007319 Predicted ATPase [General function prediction only]; Region: COG3899 760192007320 AAA ATPase domain; Region: AAA_16; pfam13191 760192007321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007322 binding surface 760192007323 TPR motif; other site 760192007324 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192007325 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192007326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007327 binding surface 760192007328 TPR motif; other site 760192007329 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192007330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007331 binding surface 760192007332 TPR motif; other site 760192007333 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192007334 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192007335 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 760192007336 Catalytic domain of Protein Kinases; Region: PKc; cd00180 760192007337 active site 760192007338 ATP binding site [chemical binding]; other site 760192007339 substrate binding site [chemical binding]; other site 760192007340 activation loop (A-loop); other site 760192007341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192007342 non-specific DNA binding site [nucleotide binding]; other site 760192007343 salt bridge; other site 760192007344 sequence-specific DNA binding site [nucleotide binding]; other site 760192007345 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 760192007346 Integral membrane protein DUF95; Region: DUF95; pfam01944 760192007347 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192007348 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192007349 catalytic residues [active] 760192007350 RDD family; Region: RDD; pfam06271 760192007351 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 760192007352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192007353 S-adenosylmethionine binding site [chemical binding]; other site 760192007354 Response regulator receiver domain; Region: Response_reg; pfam00072 760192007355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192007356 active site 760192007357 phosphorylation site [posttranslational modification] 760192007358 intermolecular recognition site; other site 760192007359 dimerization interface [polypeptide binding]; other site 760192007360 Transglycosylase; Region: Transgly; pfam00912 760192007361 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 760192007362 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 760192007363 FAD binding domain; Region: FAD_binding_4; pfam01565 760192007364 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 760192007365 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 760192007366 active site 760192007367 nucleophile elbow; other site 760192007368 CAAX protease self-immunity; Region: Abi; pfam02517 760192007369 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 760192007370 dimer interface [polypeptide binding]; other site 760192007371 catalytic triad [active] 760192007372 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 760192007373 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 760192007374 acyl-activating enzyme (AAE) consensus motif; other site 760192007375 putative AMP binding site [chemical binding]; other site 760192007376 putative active site [active] 760192007377 putative CoA binding site [chemical binding]; other site 760192007378 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192007379 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760192007380 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 760192007381 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 760192007382 Peptidase family M28; Region: Peptidase_M28; pfam04389 760192007383 metal binding site [ion binding]; metal-binding site 760192007384 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 760192007385 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 760192007386 phosphate binding site [ion binding]; other site 760192007387 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192007388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192007389 active site 760192007390 catalytic tetrad [active] 760192007391 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 760192007392 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 760192007393 metal ion-dependent adhesion site (MIDAS); other site 760192007394 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 760192007395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192007396 Coenzyme A binding pocket [chemical binding]; other site 760192007397 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 760192007398 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 760192007399 tetramer interface [polypeptide binding]; other site 760192007400 TPP-binding site [chemical binding]; other site 760192007401 heterodimer interface [polypeptide binding]; other site 760192007402 phosphorylation loop region [posttranslational modification] 760192007403 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 760192007404 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 760192007405 alpha subunit interface [polypeptide binding]; other site 760192007406 TPP binding site [chemical binding]; other site 760192007407 heterodimer interface [polypeptide binding]; other site 760192007408 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 760192007409 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192007410 putative active site [active] 760192007411 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 760192007412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192007413 Walker A/P-loop; other site 760192007414 ATP binding site [chemical binding]; other site 760192007415 Q-loop/lid; other site 760192007416 ABC transporter signature motif; other site 760192007417 Walker B; other site 760192007418 D-loop; other site 760192007419 H-loop/switch region; other site 760192007420 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 760192007421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760192007422 dimer interface [polypeptide binding]; other site 760192007423 conserved gate region; other site 760192007424 putative PBP binding loops; other site 760192007425 ABC-ATPase subunit interface; other site 760192007426 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 760192007427 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 760192007428 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192007429 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192007430 FtsX-like permease family; Region: FtsX; pfam02687 760192007431 O-Antigen ligase; Region: Wzy_C; cl04850 760192007432 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 760192007433 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192007434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 760192007435 Putative cyclase; Region: Cyclase; pfam04199 760192007436 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 760192007437 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 760192007438 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192007439 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 760192007440 catalytic motif [active] 760192007441 Catalytic residue [active] 760192007442 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 760192007443 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 760192007444 SacI restriction endonuclease; Region: RE_SacI; pfam09566 760192007445 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 760192007446 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 760192007447 cofactor binding site; other site 760192007448 DNA binding site [nucleotide binding] 760192007449 substrate interaction site [chemical binding]; other site 760192007450 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760192007451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760192007452 active site 760192007453 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 760192007454 RNA/DNA hybrid binding site [nucleotide binding]; other site 760192007455 active site 760192007456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 760192007457 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 760192007458 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 760192007459 N-acetyl-D-glucosamine binding site [chemical binding]; other site 760192007460 catalytic residue [active] 760192007461 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192007462 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192007463 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 760192007464 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 760192007465 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 760192007466 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 760192007467 trimer interface [polypeptide binding]; other site 760192007468 active site 760192007469 UDP-GlcNAc binding site [chemical binding]; other site 760192007470 lipid binding site [chemical binding]; lipid-binding site 760192007471 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 760192007472 Fasciclin domain; Region: Fasciclin; pfam02469 760192007473 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 760192007474 Conserved TM helix; Region: TM_helix; pfam05552 760192007475 Mechanosensitive ion channel; Region: MS_channel; pfam00924 760192007476 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192007477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192007478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192007479 DNA binding residues [nucleotide binding] 760192007480 Methyltransferase domain; Region: Methyltransf_11; pfam08241 760192007481 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760192007482 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 760192007483 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760192007484 protein binding site [polypeptide binding]; other site 760192007485 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 760192007486 Catalytic dyad [active] 760192007487 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 760192007488 Domain of unknown function DUF21; Region: DUF21; pfam01595 760192007489 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 760192007490 Transporter associated domain; Region: CorC_HlyC; smart01091 760192007491 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 760192007492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007493 TPR motif; other site 760192007494 TPR repeat; Region: TPR_11; pfam13414 760192007495 binding surface 760192007496 TPR repeat; Region: TPR_11; pfam13414 760192007497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007498 binding surface 760192007499 TPR motif; other site 760192007500 TPR repeat; Region: TPR_11; pfam13414 760192007501 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192007502 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 760192007503 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 760192007504 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 760192007505 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760192007506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760192007507 ABC transporter; Region: ABC_tran_2; pfam12848 760192007508 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760192007509 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 760192007510 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 760192007511 Ligand binding site; other site 760192007512 Putative Catalytic site; other site 760192007513 DXD motif; other site 760192007514 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 760192007515 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192007516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192007517 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192007518 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 760192007519 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192007520 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 760192007521 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192007522 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 760192007523 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 760192007524 gamma subunit interface [polypeptide binding]; other site 760192007525 LBP interface [polypeptide binding]; other site 760192007526 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 760192007527 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 760192007528 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 760192007529 alpha subunit interaction interface [polypeptide binding]; other site 760192007530 Walker A motif; other site 760192007531 ATP binding site [chemical binding]; other site 760192007532 Walker B motif; other site 760192007533 inhibitor binding site; inhibition site 760192007534 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 760192007535 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 760192007536 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 760192007537 active site 760192007538 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 760192007539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192007540 non-specific DNA binding site [nucleotide binding]; other site 760192007541 salt bridge; other site 760192007542 sequence-specific DNA binding site [nucleotide binding]; other site 760192007543 Heme NO binding associated; Region: HNOBA; pfam07701 760192007544 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 760192007545 cyclase homology domain; Region: CHD; cd07302 760192007546 nucleotidyl binding site; other site 760192007547 metal binding site [ion binding]; metal-binding site 760192007548 dimer interface [polypeptide binding]; other site 760192007549 excinuclease ABC subunit B; Provisional; Region: PRK05298 760192007550 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192007551 ATP binding site [chemical binding]; other site 760192007552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192007553 nucleotide binding region [chemical binding]; other site 760192007554 ATP-binding site [chemical binding]; other site 760192007555 Ultra-violet resistance protein B; Region: UvrB; pfam12344 760192007556 UvrB/uvrC motif; Region: UVR; pfam02151 760192007557 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 760192007558 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 760192007559 N-acetyl-D-glucosamine binding site [chemical binding]; other site 760192007560 catalytic residue [active] 760192007561 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 760192007562 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 760192007563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192007564 FeS/SAM binding site; other site 760192007565 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 760192007566 aromatic arch; other site 760192007567 DCoH dimer interaction site [polypeptide binding]; other site 760192007568 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 760192007569 DCoH tetramer interaction site [polypeptide binding]; other site 760192007570 substrate binding site [chemical binding]; other site 760192007571 methionine aminotransferase; Validated; Region: PRK09082 760192007572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760192007573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192007574 homodimer interface [polypeptide binding]; other site 760192007575 catalytic residue [active] 760192007576 Uncharacterized conserved protein [Function unknown]; Region: COG3339 760192007577 FOG: CBS domain [General function prediction only]; Region: COG0517 760192007578 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 760192007579 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 760192007580 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 760192007581 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 760192007582 Surface antigen; Region: Bac_surface_Ag; pfam01103 760192007583 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 760192007584 putative active site [active] 760192007585 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192007586 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 760192007587 ligand binding site [chemical binding]; other site 760192007588 flexible hinge region; other site 760192007589 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760192007590 putative switch regulator; other site 760192007591 non-specific DNA interactions [nucleotide binding]; other site 760192007592 DNA binding site [nucleotide binding] 760192007593 sequence specific DNA binding site [nucleotide binding]; other site 760192007594 putative cAMP binding site [chemical binding]; other site 760192007595 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 760192007596 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192007597 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192007598 DNA binding residues [nucleotide binding] 760192007599 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 760192007600 FecR protein; Region: FecR; pfam04773 760192007601 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192007602 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192007603 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192007604 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192007605 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192007606 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192007607 SusD family; Region: SusD; pfam07980 760192007608 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192007609 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192007610 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 760192007611 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 760192007612 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 760192007613 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 760192007614 active site 760192007615 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 760192007616 He_PIG associated, NEW1 domain of bacterial glycohydrolase; Region: He_PIG_assoc; pfam10632 760192007617 alpha-galactosidase; Region: PLN02808; cl17638 760192007618 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 760192007619 He_PIG associated, NEW1 domain of bacterial glycohydrolase; Region: He_PIG_assoc; pfam10632 760192007620 Putative Ig domain; Region: He_PIG; pfam05345 760192007621 alpha-galactosidase; Region: PLN02692 760192007622 alpha-galactosidase; Region: PLN02808; cl17638 760192007623 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 760192007624 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 760192007625 putative NAD(P) binding site [chemical binding]; other site 760192007626 putative substrate binding site [chemical binding]; other site 760192007627 catalytic Zn binding site [ion binding]; other site 760192007628 structural Zn binding site [ion binding]; other site 760192007629 dimer interface [polypeptide binding]; other site 760192007630 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192007631 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192007632 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192007633 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 760192007634 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 760192007635 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192007636 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192007637 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 760192007638 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 760192007639 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192007640 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192007641 catalytic residues [active] 760192007642 methionine sulfoxide reductase B; Provisional; Region: PRK00222 760192007643 SelR domain; Region: SelR; pfam01641 760192007644 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192007645 Sulfatase; Region: Sulfatase; pfam00884 760192007646 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 760192007647 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192007648 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192007649 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192007650 Sulfatase; Region: Sulfatase; pfam00884 760192007651 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 760192007652 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192007653 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 760192007654 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 760192007655 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 760192007656 PLD-like domain; Region: PLDc_2; pfam13091 760192007657 putative active site [active] 760192007658 catalytic site [active] 760192007659 DNA polymerase I; Provisional; Region: PRK05755 760192007660 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 760192007661 active site 760192007662 metal binding site 1 [ion binding]; metal-binding site 760192007663 putative 5' ssDNA interaction site; other site 760192007664 metal binding site 3; metal-binding site 760192007665 metal binding site 2 [ion binding]; metal-binding site 760192007666 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 760192007667 putative DNA binding site [nucleotide binding]; other site 760192007668 putative metal binding site [ion binding]; other site 760192007669 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 760192007670 active site 760192007671 catalytic site [active] 760192007672 substrate binding site [chemical binding]; other site 760192007673 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 760192007674 active site 760192007675 DNA binding site [nucleotide binding] 760192007676 catalytic site [active] 760192007677 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 760192007678 active site 760192007679 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 760192007680 Surface antigen; Region: Bac_surface_Ag; pfam01103 760192007681 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 760192007682 ATP-NAD kinase; Region: NAD_kinase; pfam01513 760192007683 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192007684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192007685 Family description; Region: VCBS; pfam13517 760192007686 Family description; Region: VCBS; pfam13517 760192007687 Family description; Region: VCBS; pfam13517 760192007688 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 760192007689 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 760192007690 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 760192007691 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 760192007692 active site 760192007693 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 760192007694 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192007695 Sulfatase; Region: Sulfatase; cl17466 760192007696 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192007697 Sulfatase; Region: Sulfatase; pfam00884 760192007698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192007699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192007700 Cupin domain; Region: Cupin_2; pfam07883 760192007701 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 760192007702 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 760192007703 active site 760192007704 metal binding site [ion binding]; metal-binding site 760192007705 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 760192007706 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 760192007707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192007708 S-adenosylmethionine binding site [chemical binding]; other site 760192007709 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 760192007710 FOG: CBS domain [General function prediction only]; Region: COG0517 760192007711 TM2 domain; Region: TM2; pfam05154 760192007712 TPR repeat; Region: TPR_11; pfam13414 760192007713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007714 binding surface 760192007715 TPR motif; other site 760192007716 Short C-terminal domain; Region: SHOCT; pfam09851 760192007717 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 760192007718 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 760192007719 Protease prsW family; Region: PrsW-protease; pfam13367 760192007720 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 760192007721 catalytic residues [active] 760192007722 dimer interface [polypeptide binding]; other site 760192007723 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 760192007724 DNA polymerase III subunit delta'; Validated; Region: PRK05564 760192007725 DNA polymerase III subunit delta'; Validated; Region: PRK08485 760192007726 PSP1 C-terminal conserved region; Region: PSP1; cl00770 760192007727 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 760192007728 nucleotide binding site/active site [active] 760192007729 HIT family signature motif; other site 760192007730 catalytic residue [active] 760192007731 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 760192007732 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 760192007733 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 760192007734 glutamate racemase; Provisional; Region: PRK00865 760192007735 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 760192007736 periplasmic chaperone; Provisional; Region: PRK10780 760192007737 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 760192007738 Mechanosensitive ion channel; Region: MS_channel; pfam00924 760192007739 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 760192007740 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192007741 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 760192007742 active site 760192007743 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 760192007744 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192007745 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192007746 ligand binding site [chemical binding]; other site 760192007747 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 760192007748 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 760192007749 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 760192007750 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 760192007751 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 760192007752 putative [Fe4-S4] binding site [ion binding]; other site 760192007753 putative molybdopterin cofactor binding site [chemical binding]; other site 760192007754 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 760192007755 putative molybdopterin cofactor binding site; other site 760192007756 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192007757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192007758 active site 760192007759 phosphorylation site [posttranslational modification] 760192007760 intermolecular recognition site; other site 760192007761 dimerization interface [polypeptide binding]; other site 760192007762 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192007763 DNA binding site [nucleotide binding] 760192007764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192007765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192007766 dimer interface [polypeptide binding]; other site 760192007767 phosphorylation site [posttranslational modification] 760192007768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192007769 ATP binding site [chemical binding]; other site 760192007770 Mg2+ binding site [ion binding]; other site 760192007771 G-X-G motif; other site 760192007772 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 760192007773 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192007774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192007775 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 760192007776 DNA binding residues [nucleotide binding] 760192007777 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192007778 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192007779 structural tetrad; other site 760192007780 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192007781 Caspase domain; Region: Peptidase_C14; pfam00656 760192007782 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 760192007783 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760192007784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192007785 homodimer interface [polypeptide binding]; other site 760192007786 catalytic residue [active] 760192007787 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 760192007788 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 760192007789 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 760192007790 active site clefts [active] 760192007791 zinc binding site [ion binding]; other site 760192007792 dimer interface [polypeptide binding]; other site 760192007793 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 760192007794 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 760192007795 Sulfate transporter family; Region: Sulfate_transp; pfam00916 760192007796 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 760192007797 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 760192007798 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 760192007799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007800 TPR motif; other site 760192007801 binding surface 760192007802 TPR repeat; Region: TPR_11; pfam13414 760192007803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007804 binding surface 760192007805 TPR motif; other site 760192007806 TPR repeat; Region: TPR_11; pfam13414 760192007807 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192007808 active site residue [active] 760192007809 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 760192007810 Cfr10I/Bse634I restriction endonuclease; Region: Bse634I; pfam07832 760192007811 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 760192007812 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 760192007813 cofactor binding site; other site 760192007814 DNA binding site [nucleotide binding] 760192007815 substrate interaction site [chemical binding]; other site 760192007816 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192007817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192007818 active site 760192007819 phosphorylation site [posttranslational modification] 760192007820 intermolecular recognition site; other site 760192007821 dimerization interface [polypeptide binding]; other site 760192007822 LytTr DNA-binding domain; Region: LytTR; smart00850 760192007823 Histidine kinase; Region: His_kinase; pfam06580 760192007824 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 760192007825 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 760192007826 E3 interaction surface; other site 760192007827 lipoyl attachment site [posttranslational modification]; other site 760192007828 e3 binding domain; Region: E3_binding; pfam02817 760192007829 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 760192007830 SdiA-regulated; Region: SdiA-regulated; pfam06977 760192007831 SdiA-regulated; Region: SdiA-regulated; cd09971 760192007832 putative active site [active] 760192007833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760192007834 active site 760192007835 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 760192007836 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 760192007837 active site 760192007838 dimerization interface [polypeptide binding]; other site 760192007839 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 760192007840 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 760192007841 catalytic residues [active] 760192007842 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 760192007843 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 760192007844 trimer interface [polypeptide binding]; other site 760192007845 putative metal binding site [ion binding]; other site 760192007846 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 760192007847 active site 760192007848 oxyanion hole [active] 760192007849 catalytic triad [active] 760192007850 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 760192007851 active site 760192007852 NTP binding site [chemical binding]; other site 760192007853 metal binding triad [ion binding]; metal-binding site 760192007854 antibiotic binding site [chemical binding]; other site 760192007855 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 760192007856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192007857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192007858 ATP binding site [chemical binding]; other site 760192007859 Mg2+ binding site [ion binding]; other site 760192007860 G-X-G motif; other site 760192007861 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192007862 active site 760192007863 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 760192007864 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760192007865 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 760192007866 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 760192007867 toxin interface [polypeptide binding]; other site 760192007868 Zn binding site [ion binding]; other site 760192007869 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 760192007870 Transposase domain (DUF772); Region: DUF772; pfam05598 760192007871 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 760192007872 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 760192007873 hydroxyglutarate oxidase; Provisional; Region: PRK11728 760192007874 Thiamine monophosphate synthase/TENI; Region: TMP-TENI; cl17228 760192007875 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192007876 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192007877 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 760192007878 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192007879 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192007880 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192007881 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192007882 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192007883 Penicillinase repressor; Region: Pencillinase_R; pfam03965 760192007884 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 760192007885 Outer membrane efflux protein; Region: OEP; pfam02321 760192007886 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 760192007887 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 760192007888 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192007889 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192007890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192007891 Walker A/P-loop; other site 760192007892 ATP binding site [chemical binding]; other site 760192007893 Q-loop/lid; other site 760192007894 ABC transporter signature motif; other site 760192007895 Walker B; other site 760192007896 D-loop; other site 760192007897 H-loop/switch region; other site 760192007898 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 760192007899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192007900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192007901 DNA binding residues [nucleotide binding] 760192007902 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 760192007903 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 760192007904 active site 760192007905 Int/Topo IB signature motif; other site 760192007906 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 760192007907 Predicted membrane protein [Function unknown]; Region: COG2261 760192007908 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192007909 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192007910 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192007911 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760192007912 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 760192007913 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760192007914 Peptidase family M28; Region: Peptidase_M28; pfam04389 760192007915 metal binding site [ion binding]; metal-binding site 760192007916 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 760192007917 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 760192007918 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 760192007919 PemK-like protein; Region: PemK; pfam02452 760192007920 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192007921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192007922 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192007923 ATP synthase A chain; Region: ATP-synt_A; cl00413 760192007924 ATP synthase subunit C; Region: ATP-synt_C; cl00466 760192007925 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 760192007926 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 760192007927 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 760192007928 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 760192007929 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 760192007930 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 760192007931 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 760192007932 beta subunit interaction interface [polypeptide binding]; other site 760192007933 Walker A motif; other site 760192007934 ATP binding site [chemical binding]; other site 760192007935 Walker B motif; other site 760192007936 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 760192007937 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 760192007938 core domain interface [polypeptide binding]; other site 760192007939 delta subunit interface [polypeptide binding]; other site 760192007940 epsilon subunit interface [polypeptide binding]; other site 760192007941 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 760192007942 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 760192007943 putative di-iron ligands [ion binding]; other site 760192007944 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192007945 ligand binding site [chemical binding]; other site 760192007946 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 760192007947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007948 binding surface 760192007949 Tetratricopeptide repeat; Region: TPR_16; pfam13432 760192007950 TPR motif; other site 760192007951 Tetratricopeptide repeat; Region: TPR_16; pfam13432 760192007952 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192007953 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 760192007954 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 760192007955 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 760192007956 Erythromycin esterase; Region: Erythro_esteras; cl17110 760192007957 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192007958 putative active site [active] 760192007959 TPR repeat; Region: TPR_11; pfam13414 760192007960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007961 binding surface 760192007962 TPR motif; other site 760192007963 Tetratricopeptide repeat; Region: TPR_16; pfam13432 760192007964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192007965 binding surface 760192007966 TPR motif; other site 760192007967 TPR repeat; Region: TPR_11; pfam13414 760192007968 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 760192007969 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 760192007970 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 760192007971 Domain of unknown function (DUF955); Region: DUF955; cl01076 760192007972 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 760192007973 Found in ATP-dependent protease La (LON); Region: LON; smart00464 760192007974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192007975 Walker A motif; other site 760192007976 ATP binding site [chemical binding]; other site 760192007977 Walker B motif; other site 760192007978 arginine finger; other site 760192007979 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 760192007980 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 760192007981 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 760192007982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192007983 nucleotide binding region [chemical binding]; other site 760192007984 ATP-binding site [chemical binding]; other site 760192007985 SEC-C motif; Region: SEC-C; pfam02810 760192007986 gamma-glutamyl kinase; Provisional; Region: PRK05429 760192007987 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 760192007988 nucleotide binding site [chemical binding]; other site 760192007989 homotetrameric interface [polypeptide binding]; other site 760192007990 putative phosphate binding site [ion binding]; other site 760192007991 putative allosteric binding site; other site 760192007992 PUA domain; Region: PUA; pfam01472 760192007993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192007994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192007995 ATP binding site [chemical binding]; other site 760192007996 Mg2+ binding site [ion binding]; other site 760192007997 G-X-G motif; other site 760192007998 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 760192007999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 760192008000 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192008001 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192008002 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192008003 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760192008004 Walker A/P-loop; other site 760192008005 ATP binding site [chemical binding]; other site 760192008006 Q-loop/lid; other site 760192008007 ABC transporter signature motif; other site 760192008008 Walker B; other site 760192008009 D-loop; other site 760192008010 H-loop/switch region; other site 760192008011 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 760192008012 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 760192008013 dockerin binding interface; other site 760192008014 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192008015 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 760192008016 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 760192008017 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 760192008018 putative acyl-acceptor binding pocket; other site 760192008019 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 760192008020 NlpC/P60 family; Region: NLPC_P60; pfam00877 760192008021 Transcriptional regulators [Transcription]; Region: FadR; COG2186 760192008022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760192008023 DNA-binding site [nucleotide binding]; DNA binding site 760192008024 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 760192008025 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 760192008026 catalytic site [active] 760192008027 BNR repeat-like domain; Region: BNR_2; pfam13088 760192008028 Asp-box motif; other site 760192008029 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 760192008030 Galactose oxidase, central domain; Region: Kelch_3; cl02701 760192008031 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 760192008032 putative transporter; Provisional; Region: PRK10484 760192008033 Na binding site [ion binding]; other site 760192008034 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 760192008035 Class I aldolases; Region: Aldolase_Class_I; cl17187 760192008036 catalytic residue [active] 760192008037 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192008038 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192008039 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192008040 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192008041 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 760192008042 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 760192008043 inhibitor-cofactor binding pocket; inhibition site 760192008044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192008045 catalytic residue [active] 760192008046 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 760192008047 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 760192008048 WxcM-like, C-terminal; Region: FdtA; pfam05523 760192008049 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 760192008050 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 760192008051 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192008052 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192008053 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192008054 ligand binding site [chemical binding]; other site 760192008055 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 760192008056 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 760192008057 FAD binding pocket [chemical binding]; other site 760192008058 FAD binding motif [chemical binding]; other site 760192008059 phosphate binding motif [ion binding]; other site 760192008060 beta-alpha-beta structure motif; other site 760192008061 NAD(p) ribose binding residues [chemical binding]; other site 760192008062 NAD binding pocket [chemical binding]; other site 760192008063 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 760192008064 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192008065 catalytic loop [active] 760192008066 iron binding site [ion binding]; other site 760192008067 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 760192008068 Fatty acid desaturase; Region: FA_desaturase; pfam00487 760192008069 Di-iron ligands [ion binding]; other site 760192008070 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 760192008071 putative SAM binding site [chemical binding]; other site 760192008072 homodimer interface [polypeptide binding]; other site 760192008073 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192008074 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192008075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192008076 Walker A/P-loop; other site 760192008077 ATP binding site [chemical binding]; other site 760192008078 Q-loop/lid; other site 760192008079 ABC transporter signature motif; other site 760192008080 Walker B; other site 760192008081 D-loop; other site 760192008082 H-loop/switch region; other site 760192008083 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 760192008084 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 760192008085 ring oligomerisation interface [polypeptide binding]; other site 760192008086 ATP/Mg binding site [chemical binding]; other site 760192008087 stacking interactions; other site 760192008088 hinge regions; other site 760192008089 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 760192008090 Zn binding site [ion binding]; other site 760192008091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 760192008092 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 760192008093 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 760192008094 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 760192008095 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 760192008096 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 760192008097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 760192008098 Caspase domain; Region: Peptidase_C14; pfam00656 760192008099 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698 760192008100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 760192008101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 760192008102 Caspase domain; Region: Peptidase_C14; pfam00656 760192008103 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760192008104 Zn2+ binding site [ion binding]; other site 760192008105 Mg2+ binding site [ion binding]; other site 760192008106 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 760192008107 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 760192008108 glycerol kinase-like protein; Provisional; Region: PTZ00294 760192008109 nucleotide binding site [chemical binding]; other site 760192008110 xylose isomerase; Provisional; Region: PRK05474 760192008111 xylose isomerase; Region: xylose_isom_A; TIGR02630 760192008112 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 760192008113 amphipathic channel; other site 760192008114 Asn-Pro-Ala signature motifs; other site 760192008115 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 760192008116 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 760192008117 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 760192008118 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 760192008119 lipoprotein signal peptidase; Provisional; Region: PRK14788 760192008120 lipoprotein signal peptidase; Provisional; Region: PRK14787 760192008121 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 760192008122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192008123 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192008124 active site 760192008125 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 760192008126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192008127 FeS/SAM binding site; other site 760192008128 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 760192008129 ribosome maturation protein RimP; Reviewed; Region: PRK00092 760192008130 Sm and related proteins; Region: Sm_like; cl00259 760192008131 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 760192008132 putative oligomer interface [polypeptide binding]; other site 760192008133 putative RNA binding site [nucleotide binding]; other site 760192008134 NusA N-terminal domain; Region: NusA_N; pfam08529 760192008135 transcription termination factor NusA; Region: NusA; TIGR01953 760192008136 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 760192008137 RNA binding site [nucleotide binding]; other site 760192008138 homodimer interface [polypeptide binding]; other site 760192008139 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 760192008140 G-X-X-G motif; other site 760192008141 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 760192008142 G-X-X-G motif; other site 760192008143 translation initiation factor IF-2; Region: IF-2; TIGR00487 760192008144 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 760192008145 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 760192008146 G1 box; other site 760192008147 putative GEF interaction site [polypeptide binding]; other site 760192008148 GTP/Mg2+ binding site [chemical binding]; other site 760192008149 Switch I region; other site 760192008150 G2 box; other site 760192008151 G3 box; other site 760192008152 Switch II region; other site 760192008153 G4 box; other site 760192008154 G5 box; other site 760192008155 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 760192008156 Translation-initiation factor 2; Region: IF-2; pfam11987 760192008157 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 760192008158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192008159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192008160 active site 760192008161 phosphorylation site [posttranslational modification] 760192008162 intermolecular recognition site; other site 760192008163 dimerization interface [polypeptide binding]; other site 760192008164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192008165 DNA binding site [nucleotide binding] 760192008166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192008167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192008168 dimer interface [polypeptide binding]; other site 760192008169 phosphorylation site [posttranslational modification] 760192008170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192008171 ATP binding site [chemical binding]; other site 760192008172 Mg2+ binding site [ion binding]; other site 760192008173 G-X-G motif; other site 760192008174 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 760192008175 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 760192008176 acyl-activating enzyme (AAE) consensus motif; other site 760192008177 putative AMP binding site [chemical binding]; other site 760192008178 putative active site [active] 760192008179 putative CoA binding site [chemical binding]; other site 760192008180 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 760192008181 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 760192008182 acyl-activating enzyme (AAE) consensus motif; other site 760192008183 putative AMP binding site [chemical binding]; other site 760192008184 putative active site [active] 760192008185 putative CoA binding site [chemical binding]; other site 760192008186 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 760192008187 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 760192008188 RNA binding site [nucleotide binding]; other site 760192008189 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 760192008190 RNA binding site [nucleotide binding]; other site 760192008191 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 760192008192 RNA binding site [nucleotide binding]; other site 760192008193 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 760192008194 RNA binding site [nucleotide binding]; other site 760192008195 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 760192008196 RNA binding site [nucleotide binding]; other site 760192008197 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 760192008198 RNA binding site [nucleotide binding]; other site 760192008199 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 760192008200 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 760192008201 nucleoside transporter; Region: 2A0110; TIGR00889 760192008202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192008203 putative substrate translocation pore; other site 760192008204 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 760192008205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192008206 ATP binding site [chemical binding]; other site 760192008207 Mg2+ binding site [ion binding]; other site 760192008208 G-X-G motif; other site 760192008209 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 760192008210 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 760192008211 ATP binding site [chemical binding]; other site 760192008212 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 760192008213 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 760192008214 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 760192008215 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 760192008216 putative catalytic site [active] 760192008217 putative metal binding site [ion binding]; other site 760192008218 putative phosphate binding site [ion binding]; other site 760192008219 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 760192008220 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 760192008221 active site 760192008222 HIGH motif; other site 760192008223 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 760192008224 KMSKS motif; other site 760192008225 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 760192008226 tRNA binding surface [nucleotide binding]; other site 760192008227 anticodon binding site; other site 760192008228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192008229 binding surface 760192008230 TPR motif; other site 760192008231 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192008232 binding surface 760192008233 TPR repeat; Region: TPR_11; pfam13414 760192008234 TPR motif; other site 760192008235 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192008236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192008237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192008238 DNA binding residues [nucleotide binding] 760192008239 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 760192008240 nudix motif; other site 760192008241 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 760192008242 putative active site [active] 760192008243 Zn binding site [ion binding]; other site 760192008244 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 760192008245 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 760192008246 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192008247 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 760192008248 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192008249 SnoaL-like domain; Region: SnoaL_2; pfam12680 760192008250 NmrA-like family; Region: NmrA; pfam05368 760192008251 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 760192008252 NADP binding site [chemical binding]; other site 760192008253 active site 760192008254 regulatory binding site [polypeptide binding]; other site 760192008255 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490 760192008256 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 760192008257 GTP binding site; other site 760192008258 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 760192008259 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192008260 inhibitor-cofactor binding pocket; inhibition site 760192008261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192008262 catalytic residue [active] 760192008263 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 760192008264 Clp amino terminal domain; Region: Clp_N; pfam02861 760192008265 Clp amino terminal domain; Region: Clp_N; pfam02861 760192008266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192008267 Walker A motif; other site 760192008268 ATP binding site [chemical binding]; other site 760192008269 Walker B motif; other site 760192008270 arginine finger; other site 760192008271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192008272 Walker A motif; other site 760192008273 ATP binding site [chemical binding]; other site 760192008274 Walker B motif; other site 760192008275 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 760192008276 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 760192008277 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 760192008278 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 760192008279 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 760192008280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192008281 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192008282 DNA binding residues [nucleotide binding] 760192008283 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760192008284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 760192008285 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 760192008286 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 760192008287 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 760192008288 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 760192008289 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 760192008290 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 760192008291 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 760192008292 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 760192008293 active site 760192008294 (T/H)XGH motif; other site 760192008295 Domain of unknown function (DUF3506); Region: DUF3506; pfam12014 760192008296 DNA polymerase III subunit beta; Validated; Region: PRK05643 760192008297 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 760192008298 putative DNA binding surface [nucleotide binding]; other site 760192008299 dimer interface [polypeptide binding]; other site 760192008300 beta-clamp/clamp loader binding surface; other site 760192008301 beta-clamp/translesion DNA polymerase binding surface; other site 760192008302 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 760192008303 tetramerization interface [polypeptide binding]; other site 760192008304 active site 760192008305 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192008306 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192008307 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 760192008308 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760192008309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192008310 NAD(P) binding site [chemical binding]; other site 760192008311 active site 760192008312 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760192008313 SurA N-terminal domain; Region: SurA_N_3; cl07813 760192008314 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 760192008315 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 760192008316 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 760192008317 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192008318 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 760192008319 DNA binding site [nucleotide binding] 760192008320 active site 760192008321 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 760192008322 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 760192008323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 760192008324 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 760192008325 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 760192008326 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 760192008327 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192008328 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 760192008329 active site 760192008330 metal binding site [ion binding]; metal-binding site 760192008331 Penicillinase repressor; Region: Pencillinase_R; pfam03965 760192008332 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 760192008333 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 760192008334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192008335 NAD(P) binding site [chemical binding]; other site 760192008336 active site 760192008337 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 760192008338 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 760192008339 Phosphotransferase enzyme family; Region: APH; pfam01636 760192008340 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 760192008341 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 760192008342 Chain length determinant protein; Region: Wzz; cl15801 760192008343 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 760192008344 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 760192008345 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760192008346 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 760192008347 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192008348 UDP-galactopyranose mutase; Region: GLF; pfam03275 760192008349 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 760192008350 SLBB domain; Region: SLBB; pfam10531 760192008351 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 760192008352 active site 760192008353 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 760192008354 homodimer interface [polypeptide binding]; other site 760192008355 PHP domain; Region: PHP; pfam02811 760192008356 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760192008357 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 760192008358 putative NAD(P) binding site [chemical binding]; other site 760192008359 active site 760192008360 putative substrate binding site [chemical binding]; other site 760192008361 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 760192008362 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 760192008363 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 760192008364 inhibitor-cofactor binding pocket; inhibition site 760192008365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192008366 catalytic residue [active] 760192008367 Predicted dehydrogenase [General function prediction only]; Region: COG0579 760192008368 hydroxyglutarate oxidase; Provisional; Region: PRK11728 760192008369 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 760192008370 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 760192008371 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 760192008372 quinone interaction residues [chemical binding]; other site 760192008373 active site 760192008374 catalytic residues [active] 760192008375 FMN binding site [chemical binding]; other site 760192008376 substrate binding site [chemical binding]; other site 760192008377 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 760192008378 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 760192008379 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 760192008380 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 760192008381 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 760192008382 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 760192008383 histidinol dehydrogenase; Region: hisD; TIGR00069 760192008384 NAD binding site [chemical binding]; other site 760192008385 dimerization interface [polypeptide binding]; other site 760192008386 product binding site; other site 760192008387 substrate binding site [chemical binding]; other site 760192008388 zinc binding site [ion binding]; other site 760192008389 catalytic residues [active] 760192008390 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 760192008391 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760192008392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192008393 homodimer interface [polypeptide binding]; other site 760192008394 catalytic residue [active] 760192008395 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 760192008396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192008397 active site 760192008398 motif I; other site 760192008399 motif II; other site 760192008400 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 760192008401 putative active site pocket [active] 760192008402 4-fold oligomerization interface [polypeptide binding]; other site 760192008403 metal binding residues [ion binding]; metal-binding site 760192008404 3-fold/trimer interface [polypeptide binding]; other site 760192008405 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 760192008406 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 760192008407 putative active site [active] 760192008408 oxyanion strand; other site 760192008409 catalytic triad [active] 760192008410 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 760192008411 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 760192008412 catalytic residues [active] 760192008413 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 760192008414 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 760192008415 substrate binding site [chemical binding]; other site 760192008416 glutamase interaction surface [polypeptide binding]; other site 760192008417 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 760192008418 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192008419 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 760192008420 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 760192008421 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 760192008422 Tetratricopeptide repeat; Region: TPR_16; pfam13432 760192008423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192008424 binding surface 760192008425 TPR motif; other site 760192008426 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192008427 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192008428 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192008429 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192008430 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 760192008431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192008432 binding surface 760192008433 TPR motif; other site 760192008434 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 760192008435 metal ion-dependent adhesion site (MIDAS); other site 760192008436 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 760192008437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192008438 Walker A/P-loop; other site 760192008439 ATP binding site [chemical binding]; other site 760192008440 Q-loop/lid; other site 760192008441 ABC transporter signature motif; other site 760192008442 Walker B; other site 760192008443 D-loop; other site 760192008444 H-loop/switch region; other site 760192008445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192008446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192008447 non-specific DNA binding site [nucleotide binding]; other site 760192008448 salt bridge; other site 760192008449 sequence-specific DNA binding site [nucleotide binding]; other site 760192008450 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 760192008451 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192008452 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192008453 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 760192008454 SmpB-tmRNA interface; other site 760192008455 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 760192008456 HemN C-terminal domain; Region: HemN_C; pfam06969 760192008457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192008458 S-adenosylmethionine binding site [chemical binding]; other site 760192008459 Rrf2 family protein; Region: rrf2_super; TIGR00738 760192008460 Transcriptional regulator; Region: Rrf2; pfam02082 760192008461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 760192008462 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 760192008463 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192008464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192008465 AAA domain; Region: AAA_21; pfam13304 760192008466 Walker A/P-loop; other site 760192008467 ATP binding site [chemical binding]; other site 760192008468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192008469 Walker B; other site 760192008470 D-loop; other site 760192008471 H-loop/switch region; other site 760192008472 Src Homology 3 domain superfamily; Region: SH3; cl17036 760192008473 peptide ligand binding site [polypeptide binding]; other site 760192008474 glycyl-tRNA synthetase; Provisional; Region: PRK04173 760192008475 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 760192008476 motif 1; other site 760192008477 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 760192008478 active site 760192008479 motif 2; other site 760192008480 motif 3; other site 760192008481 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 760192008482 anticodon binding site; other site 760192008483 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 760192008484 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 760192008485 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 760192008486 active site 760192008487 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 760192008488 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 760192008489 NAD binding site [chemical binding]; other site 760192008490 homodimer interface [polypeptide binding]; other site 760192008491 active site 760192008492 substrate binding site [chemical binding]; other site 760192008493 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192008494 active site 760192008495 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 760192008496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192008497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192008498 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 760192008499 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 760192008500 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 760192008501 dimerization interface 3.5A [polypeptide binding]; other site 760192008502 active site 760192008503 DinB superfamily; Region: DinB_2; pfam12867 760192008504 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 760192008505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192008506 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 760192008507 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 760192008508 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192008509 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 760192008510 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192008511 active site 760192008512 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 760192008513 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 760192008514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192008515 ATP binding site [chemical binding]; other site 760192008516 putative Mg++ binding site [ion binding]; other site 760192008517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192008518 nucleotide binding region [chemical binding]; other site 760192008519 ATP-binding site [chemical binding]; other site 760192008520 TRCF domain; Region: TRCF; pfam03461 760192008521 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192008522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 760192008523 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192008524 putative active site [active] 760192008525 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192008526 putative active site [active] 760192008527 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 760192008528 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 760192008529 Substrate binding site; other site 760192008530 metal-binding site 760192008531 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192008532 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192008533 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192008534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192008535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192008536 putative substrate translocation pore; other site 760192008537 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192008538 BNR repeat-like domain; Region: BNR_2; pfam13088 760192008539 BNR repeat-like domain; Region: BNR_2; pfam13088 760192008540 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192008541 putative active site [active] 760192008542 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 760192008543 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 760192008544 active site residue [active] 760192008545 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192008546 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192008547 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 760192008548 Outer membrane efflux protein; Region: OEP; pfam02321 760192008549 Outer membrane efflux protein; Region: OEP; pfam02321 760192008550 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 760192008551 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 760192008552 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 760192008553 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192008554 putative active site [active] 760192008555 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 760192008556 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192008557 catalytic residue [active] 760192008558 Protein of unknown function DUF45; Region: DUF45; pfam01863 760192008559 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 760192008560 Pirin-related protein [General function prediction only]; Region: COG1741 760192008561 Pirin; Region: Pirin; pfam02678 760192008562 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 760192008563 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 760192008564 Predicted membrane protein [Function unknown]; Region: COG2246 760192008565 GtrA-like protein; Region: GtrA; pfam04138 760192008566 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 760192008567 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 760192008568 active site 760192008569 substrate binding site [chemical binding]; other site 760192008570 cosubstrate binding site; other site 760192008571 catalytic site [active] 760192008572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192008573 binding surface 760192008574 TPR motif; other site 760192008575 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 760192008576 Sporulation related domain; Region: SPOR; pfam05036 760192008577 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 760192008578 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760192008579 RNA binding surface [nucleotide binding]; other site 760192008580 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 760192008581 active site 760192008582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 760192008583 Transposase; Region: DEDD_Tnp_IS110; pfam01548 760192008584 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 760192008585 Protein of unknown function DUF262; Region: DUF262; pfam03235 760192008586 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192008587 active site 760192008588 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 760192008589 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 760192008590 active site 760192008591 substrate binding site [chemical binding]; other site 760192008592 coenzyme B12 binding site [chemical binding]; other site 760192008593 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 760192008594 B12 binding site [chemical binding]; other site 760192008595 cobalt ligand [ion binding]; other site 760192008596 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 760192008597 phosphoglyceromutase; Provisional; Region: PRK05434 760192008598 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192008599 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192008600 SusD family; Region: SusD; pfam07980 760192008601 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192008602 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192008603 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192008604 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192008605 L-aspartate oxidase; Provisional; Region: PRK09077 760192008606 L-aspartate oxidase; Provisional; Region: PRK06175 760192008607 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 760192008608 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 760192008609 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192008610 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 760192008611 Metal-binding active site; metal-binding site 760192008612 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 760192008613 active site triad [active] 760192008614 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192008615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192008616 active site 760192008617 phosphorylation site [posttranslational modification] 760192008618 intermolecular recognition site; other site 760192008619 dimerization interface [polypeptide binding]; other site 760192008620 LytTr DNA-binding domain; Region: LytTR; smart00850 760192008621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192008622 TPR motif; other site 760192008623 binding surface 760192008624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192008625 TPR repeat; Region: TPR_11; pfam13414 760192008626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192008627 binding surface 760192008628 TPR motif; other site 760192008629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192008630 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192008631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192008632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192008633 ATP binding site [chemical binding]; other site 760192008634 Mg2+ binding site [ion binding]; other site 760192008635 G-X-G motif; other site 760192008636 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 760192008637 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 760192008638 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 760192008639 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 760192008640 active site 760192008641 nucleotide binding site [chemical binding]; other site 760192008642 HIGH motif; other site 760192008643 KMSKS motif; other site 760192008644 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 760192008645 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192008646 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 760192008647 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 760192008648 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 760192008649 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 760192008650 minor groove reading motif; other site 760192008651 helix-hairpin-helix signature motif; other site 760192008652 substrate binding pocket [chemical binding]; other site 760192008653 active site 760192008654 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 760192008655 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 760192008656 DNA binding and oxoG recognition site [nucleotide binding] 760192008657 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192008658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192008659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192008660 DNA binding residues [nucleotide binding] 760192008661 Predicted permeases [General function prediction only]; Region: COG0795 760192008662 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 760192008663 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 760192008664 Protein of unknown function DUF58; Region: DUF58; pfam01882 760192008665 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 760192008666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 760192008667 Beta-Casp domain; Region: Beta-Casp; smart01027 760192008668 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 760192008669 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192008670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192008671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192008672 DNA binding residues [nucleotide binding] 760192008673 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 760192008674 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192008675 AAA domain; Region: AAA_14; pfam13173 760192008676 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 760192008677 Nuclease-related domain; Region: NERD; pfam08378 760192008678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192008679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192008680 Outer membrane efflux protein; Region: OEP; pfam02321 760192008681 Outer membrane efflux protein; Region: OEP; pfam02321 760192008682 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 760192008683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 760192008684 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 760192008685 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192008686 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760192008687 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760192008688 Walker A/P-loop; other site 760192008689 ATP binding site [chemical binding]; other site 760192008690 Q-loop/lid; other site 760192008691 ABC transporter signature motif; other site 760192008692 Walker B; other site 760192008693 D-loop; other site 760192008694 H-loop/switch region; other site 760192008695 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760192008696 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 760192008697 Walker A/P-loop; other site 760192008698 ATP binding site [chemical binding]; other site 760192008699 Q-loop/lid; other site 760192008700 ABC transporter signature motif; other site 760192008701 Walker B; other site 760192008702 D-loop; other site 760192008703 H-loop/switch region; other site 760192008704 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 760192008705 ABC-2 type transporter; Region: ABC2_membrane; cl17235 760192008706 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 760192008707 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 760192008708 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 760192008709 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 760192008710 KilA-N domain; Region: KilA-N; pfam04383 760192008711 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 760192008712 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 760192008713 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 760192008714 folate binding site [chemical binding]; other site 760192008715 NADP+ binding site [chemical binding]; other site 760192008716 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 760192008717 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 760192008718 putative active site [active] 760192008719 putative metal binding site [ion binding]; other site 760192008720 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 760192008721 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 760192008722 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 760192008723 rod shape-determining protein MreC; Provisional; Region: PRK13922 760192008724 rod shape-determining protein MreC; Region: MreC; pfam04085 760192008725 rod shape-determining protein MreB; Provisional; Region: PRK13927 760192008726 MreB and similar proteins; Region: MreB_like; cd10225 760192008727 nucleotide binding site [chemical binding]; other site 760192008728 Mg binding site [ion binding]; other site 760192008729 putative protofilament interaction site [polypeptide binding]; other site 760192008730 RodZ interaction site [polypeptide binding]; other site 760192008731 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192008732 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192008733 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192008734 Sulfatase; Region: Sulfatase; pfam00884 760192008735 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 760192008736 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192008737 Sulfatase; Region: Sulfatase; pfam00884 760192008738 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760192008739 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 760192008740 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 760192008741 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192008742 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 760192008743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192008744 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192008745 DNA binding residues [nucleotide binding] 760192008746 Anti-sigma-K factor rskA; Region: RskA; pfam10099 760192008747 FecR protein; Region: FecR; pfam04773 760192008748 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192008749 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192008750 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192008751 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 760192008752 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192008753 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192008754 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192008755 SusD family; Region: SusD; pfam07980 760192008756 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 760192008757 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 760192008758 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 760192008759 Trp docking motif [polypeptide binding]; other site 760192008760 PQQ-like domain; Region: PQQ_2; pfam13360 760192008761 putative active site [active] 760192008762 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 760192008763 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192008764 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 760192008765 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192008766 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192008767 Sulfatase; Region: Sulfatase; pfam00884 760192008768 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 760192008769 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 760192008770 E3 interaction surface; other site 760192008771 lipoyl attachment site [posttranslational modification]; other site 760192008772 e3 binding domain; Region: E3_binding; pfam02817 760192008773 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 760192008774 competence damage-inducible protein A; Provisional; Region: PRK00549 760192008775 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 760192008776 putative MPT binding site; other site 760192008777 Competence-damaged protein; Region: CinA; pfam02464 760192008778 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 760192008779 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 760192008780 Oligomerisation domain; Region: Oligomerisation; pfam02410 760192008781 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 760192008782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192008783 Walker A motif; other site 760192008784 ATP binding site [chemical binding]; other site 760192008785 Walker B motif; other site 760192008786 arginine finger; other site 760192008787 Peptidase family M41; Region: Peptidase_M41; pfam01434 760192008788 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 760192008789 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 760192008790 active site 760192008791 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 760192008792 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 760192008793 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760192008794 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 760192008795 PA/protease or protease-like domain interface [polypeptide binding]; other site 760192008796 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 760192008797 Peptidase family M28; Region: Peptidase_M28; pfam04389 760192008798 metal binding site [ion binding]; metal-binding site 760192008799 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 760192008800 Zn binding site [ion binding]; other site 760192008801 PIN domain; Region: PIN_3; pfam13470 760192008802 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 760192008803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192008804 Walker A motif; other site 760192008805 ATP binding site [chemical binding]; other site 760192008806 Walker B motif; other site 760192008807 arginine finger; other site 760192008808 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 760192008809 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 760192008810 NAD synthetase; Provisional; Region: PRK13981 760192008811 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 760192008812 multimer interface [polypeptide binding]; other site 760192008813 active site 760192008814 catalytic triad [active] 760192008815 protein interface 1 [polypeptide binding]; other site 760192008816 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 760192008817 homodimer interface [polypeptide binding]; other site 760192008818 NAD binding pocket [chemical binding]; other site 760192008819 ATP binding pocket [chemical binding]; other site 760192008820 Mg binding site [ion binding]; other site 760192008821 active-site loop [active] 760192008822 NIPSNAP; Region: NIPSNAP; pfam07978 760192008823 NIPSNAP; Region: NIPSNAP; pfam07978 760192008824 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 760192008825 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 760192008826 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 760192008827 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 760192008828 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 760192008829 Ligand binding site; other site 760192008830 Putative Catalytic site; other site 760192008831 DXD motif; other site 760192008832 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 760192008833 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 760192008834 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 760192008835 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 760192008836 four helix bundle protein; Region: TIGR02436 760192008837 MoxR-like ATPases [General function prediction only]; Region: COG0714 760192008838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192008839 Walker A motif; other site 760192008840 ATP binding site [chemical binding]; other site 760192008841 Walker B motif; other site 760192008842 arginine finger; other site 760192008843 heat shock protein 90; Provisional; Region: PRK05218 760192008844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192008845 ATP binding site [chemical binding]; other site 760192008846 Mg2+ binding site [ion binding]; other site 760192008847 G-X-G motif; other site 760192008848 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192008849 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192008850 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 760192008851 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 760192008852 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192008853 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 760192008854 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 760192008855 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 760192008856 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 760192008857 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192008858 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 760192008859 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 760192008860 MoxR-like ATPases [General function prediction only]; Region: COG0714 760192008861 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 760192008862 Walker A motif; other site 760192008863 ATP binding site [chemical binding]; other site 760192008864 Walker B motif; other site 760192008865 arginine finger; other site 760192008866 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 760192008867 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 760192008868 putative ligand binding site [chemical binding]; other site 760192008869 NAD binding site [chemical binding]; other site 760192008870 dimerization interface [polypeptide binding]; other site 760192008871 catalytic site [active] 760192008872 Predicted transcriptional regulators [Transcription]; Region: COG1510 760192008873 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192008874 putative DNA binding site [nucleotide binding]; other site 760192008875 putative Zn2+ binding site [ion binding]; other site 760192008876 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 760192008877 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 760192008878 HEAT repeats; Region: HEAT_2; pfam13646 760192008879 HEAT repeat; Region: HEAT; pfam02985 760192008880 HEAT repeats; Region: HEAT_2; pfam13646 760192008881 HEAT repeats; Region: HEAT_2; pfam13646 760192008882 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 760192008883 active site 760192008884 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 760192008885 Transglycosylase; Region: Transgly; pfam00912 760192008886 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 760192008887 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 760192008888 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 760192008889 active site 760192008890 dimer interface [polypeptide binding]; other site 760192008891 metal binding site [ion binding]; metal-binding site 760192008892 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192008893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192008894 non-specific DNA binding site [nucleotide binding]; other site 760192008895 salt bridge; other site 760192008896 sequence-specific DNA binding site [nucleotide binding]; other site 760192008897 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 760192008898 active site 760192008899 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192008900 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192008901 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192008902 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 760192008903 active site 760192008904 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 760192008905 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192008906 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 760192008907 replicative DNA helicase; Validated; Region: PRK07773 760192008908 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 760192008909 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 760192008910 Walker A motif; other site 760192008911 ATP binding site [chemical binding]; other site 760192008912 Walker B motif; other site 760192008913 DNA binding loops [nucleotide binding] 760192008914 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 760192008915 protein-splicing catalytic site; other site 760192008916 thioester formation/cholesterol transfer; other site 760192008917 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 760192008918 protein-splicing catalytic site; other site 760192008919 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 760192008920 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760192008921 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 760192008922 Walker A/P-loop; other site 760192008923 ATP binding site [chemical binding]; other site 760192008924 Q-loop/lid; other site 760192008925 ABC transporter signature motif; other site 760192008926 Walker B; other site 760192008927 D-loop; other site 760192008928 H-loop/switch region; other site 760192008929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 760192008930 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 760192008931 Histidine kinase; Region: His_kinase; pfam06580 760192008932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192008933 Response regulator receiver domain; Region: Response_reg; pfam00072 760192008934 active site 760192008935 phosphorylation site [posttranslational modification] 760192008936 intermolecular recognition site; other site 760192008937 dimerization interface [polypeptide binding]; other site 760192008938 LytTr DNA-binding domain; Region: LytTR; smart00850 760192008939 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 760192008940 Recombination protein O N terminal; Region: RecO_N; pfam11967 760192008941 Recombination protein O C terminal; Region: RecO_C; pfam02565 760192008942 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 760192008943 Surface antigen; Region: Bac_surface_Ag; pfam01103 760192008944 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 760192008945 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 760192008946 Protein of unknown function, DUF608; Region: DUF608; pfam04685 760192008947 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 760192008948 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 760192008949 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 760192008950 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192008951 AAA domain; Region: AAA_14; pfam13173 760192008952 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 760192008953 acyl-CoA synthetase; Validated; Region: PRK05850 760192008954 acyl-activating enzyme (AAE) consensus motif; other site 760192008955 active site 760192008956 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 760192008957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192008958 NAD(P) binding site [chemical binding]; other site 760192008959 active site 760192008960 Fatty acid desaturase; Region: FA_desaturase; pfam00487 760192008961 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 760192008962 putative di-iron ligands [ion binding]; other site 760192008963 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192008964 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192008965 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192008966 Trehalose utilisation; Region: ThuA; pfam06283 760192008967 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192008968 HEAT repeats; Region: HEAT_2; pfam13646 760192008969 Cytochrome c; Region: Cytochrom_C; pfam00034 760192008970 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 760192008971 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192008972 DNA binding residues [nucleotide binding] 760192008973 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192008974 SusD family; Region: SusD; pfam07980 760192008975 Secretin and TonB N terminus short domain; Region: STN; pfam07660 760192008976 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192008977 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192008978 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192008979 FecR protein; Region: FecR; pfam04773 760192008980 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192008981 FtsX-like permease family; Region: FtsX; pfam02687 760192008982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192008983 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760192008984 Walker A/P-loop; other site 760192008985 ATP binding site [chemical binding]; other site 760192008986 Q-loop/lid; other site 760192008987 ABC transporter signature motif; other site 760192008988 Walker B; other site 760192008989 D-loop; other site 760192008990 H-loop/switch region; other site 760192008991 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760192008992 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760192008993 active site 760192008994 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 760192008995 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 760192008996 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 760192008997 oligomer interface [polypeptide binding]; other site 760192008998 active site 760192008999 metal binding site [ion binding]; metal-binding site 760192009000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192009001 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 760192009002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760192009003 dimerization interface [polypeptide binding]; other site 760192009004 PAS domain; Region: PAS; smart00091 760192009005 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 760192009006 putative active site [active] 760192009007 heme pocket [chemical binding]; other site 760192009008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192009009 ATP binding site [chemical binding]; other site 760192009010 Mg2+ binding site [ion binding]; other site 760192009011 G-X-G motif; other site 760192009012 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 760192009013 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 760192009014 putative active site [active] 760192009015 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 760192009016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192009017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192009018 4Fe-4S binding domain; Region: Fer4; pfam00037 760192009019 4Fe-4S binding domain; Region: Fer4; pfam00037 760192009020 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 760192009021 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 760192009022 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 760192009023 dimer interface [polypeptide binding]; other site 760192009024 PYR/PP interface [polypeptide binding]; other site 760192009025 TPP binding site [chemical binding]; other site 760192009026 substrate binding site [chemical binding]; other site 760192009027 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 760192009028 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 760192009029 TPP-binding site [chemical binding]; other site 760192009030 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 760192009031 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192009032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192009033 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192009034 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192009035 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192009036 putative RNA ligase; Region: PHA02142 760192009037 RNA ligase; Region: RNA_ligase; pfam09414 760192009038 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192009039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192009040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192009041 DNA binding residues [nucleotide binding] 760192009042 HEAT repeats; Region: HEAT_2; pfam13646 760192009043 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 760192009044 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 760192009045 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 760192009046 NmrA-like family; Region: NmrA; pfam05368 760192009047 NADP binding site [chemical binding]; other site 760192009048 active site 760192009049 regulatory binding site [polypeptide binding]; other site 760192009050 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192009051 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009052 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009053 FtsX-like permease family; Region: FtsX; pfam02687 760192009054 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192009055 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 760192009056 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192009057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192009058 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 760192009059 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 760192009060 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 760192009061 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760192009062 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 760192009063 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 760192009064 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760192009065 catalytic residues [active] 760192009066 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192009067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192009068 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 760192009069 putative ADP-binding pocket [chemical binding]; other site 760192009070 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 760192009071 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 760192009072 Substrate binding site; other site 760192009073 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 760192009074 active site 760192009075 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 760192009076 putative active site [active] 760192009077 catalytic site [active] 760192009078 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192009079 kynureninase; Region: kynureninase; TIGR01814 760192009080 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192009081 catalytic residue [active] 760192009082 Protein of unknown function, DUF481; Region: DUF481; cl01213 760192009083 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 760192009084 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192009085 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 760192009086 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 760192009087 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 760192009088 active site pocket [active] 760192009089 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 760192009090 Sodium Bile acid symporter family; Region: SBF; pfam01758 760192009091 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760192009092 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 760192009093 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760192009094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192009095 Walker A/P-loop; other site 760192009096 ATP binding site [chemical binding]; other site 760192009097 Q-loop/lid; other site 760192009098 ABC transporter signature motif; other site 760192009099 Walker B; other site 760192009100 D-loop; other site 760192009101 H-loop/switch region; other site 760192009102 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 760192009103 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 760192009104 Protein export membrane protein; Region: SecD_SecF; cl14618 760192009105 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192009106 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 760192009107 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192009108 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 760192009109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192009110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192009111 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 760192009112 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 760192009113 putative metal binding site [ion binding]; other site 760192009114 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 760192009115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192009116 WYL domain; Region: WYL; pfam13280 760192009117 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192009118 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 760192009119 putative active site [active] 760192009120 putative NTP binding site [chemical binding]; other site 760192009121 putative nucleic acid binding site [nucleotide binding]; other site 760192009122 translation initiation factor IF-2; Provisional; Region: PRK14845 760192009123 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192009124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192009125 active site 760192009126 phosphorylation site [posttranslational modification] 760192009127 intermolecular recognition site; other site 760192009128 AAA domain; Region: AAA_30; pfam13604 760192009129 Family description; Region: UvrD_C_2; pfam13538 760192009130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 760192009131 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760192009132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760192009133 DNA binding site [nucleotide binding] 760192009134 domain linker motif; other site 760192009135 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760192009136 dimerization interface [polypeptide binding]; other site 760192009137 ligand binding site [chemical binding]; other site 760192009138 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192009139 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192009140 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192009141 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192009142 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192009143 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192009144 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192009145 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 760192009146 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 760192009147 active site 760192009148 zinc binding site [ion binding]; other site 760192009149 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 760192009150 Na binding site [ion binding]; other site 760192009151 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760192009152 beta-D-glucuronidase; Provisional; Region: PRK10150 760192009153 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760192009154 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760192009155 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 760192009156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192009157 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 760192009158 Photosystem II protein; Region: PSII; cl08223 760192009159 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 760192009160 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192009161 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192009162 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 760192009163 Metal-binding active site; metal-binding site 760192009164 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192009165 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192009166 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192009167 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 760192009168 four helix bundle protein; Region: TIGR02436 760192009169 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 760192009170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192009171 NAD(P) binding site [chemical binding]; other site 760192009172 active site 760192009173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192009174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192009175 putative substrate translocation pore; other site 760192009176 Family of unknown function (DUF490); Region: DUF490; pfam04357 760192009177 Surface antigen; Region: Bac_surface_Ag; pfam01103 760192009178 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 760192009179 dimer interface [polypeptide binding]; other site 760192009180 active site 760192009181 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760192009182 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760192009183 nucleotide binding site [chemical binding]; other site 760192009184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192009185 putative substrate translocation pore; other site 760192009186 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192009187 Cytochrome c; Region: Cytochrom_C; pfam00034 760192009188 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 760192009189 DsrE/DsrF-like family; Region: DrsE; pfam02635 760192009190 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192009191 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 760192009192 active site 760192009193 catalytic triad [active] 760192009194 oxyanion hole [active] 760192009195 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 760192009196 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 760192009197 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192009198 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192009199 catalytic residues [active] 760192009200 Right handed beta helix region; Region: Beta_helix; pfam13229 760192009201 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192009202 protein binding site [polypeptide binding]; other site 760192009203 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 760192009204 Sulfatase; Region: Sulfatase; cl17466 760192009205 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192009206 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 760192009207 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 760192009208 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 760192009209 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 760192009210 active site 760192009211 catalytic site [active] 760192009212 Alginate lyase; Region: Alginate_lyase; pfam05426 760192009213 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 760192009214 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192009215 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192009216 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192009217 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192009218 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192009219 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192009220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192009221 active site 760192009222 phosphorylation site [posttranslational modification] 760192009223 intermolecular recognition site; other site 760192009224 dimerization interface [polypeptide binding]; other site 760192009225 LytTr DNA-binding domain; Region: LytTR; smart00850 760192009226 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192009227 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760192009228 Walker A/P-loop; other site 760192009229 ATP binding site [chemical binding]; other site 760192009230 Q-loop/lid; other site 760192009231 ABC transporter signature motif; other site 760192009232 Walker B; other site 760192009233 D-loop; other site 760192009234 H-loop/switch region; other site 760192009235 FtsX-like permease family; Region: FtsX; pfam02687 760192009236 Histidine kinase; Region: His_kinase; pfam06580 760192009237 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 760192009238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192009239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192009240 TPR motif; other site 760192009241 binding surface 760192009242 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 760192009243 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192009244 substrate binding pocket [chemical binding]; other site 760192009245 catalytic triad [active] 760192009246 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 760192009247 nudix motif; other site 760192009248 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 760192009249 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 760192009250 Malonate transporter MadL subunit; Region: MadL; cl04273 760192009251 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 760192009252 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 760192009253 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 760192009254 dihydrodipicolinate synthase; Region: dapA; TIGR00674 760192009255 dimer interface [polypeptide binding]; other site 760192009256 active site 760192009257 catalytic residue [active] 760192009258 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 760192009259 Cytochrome P450; Region: p450; pfam00067 760192009260 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 760192009261 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192009262 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 760192009263 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 760192009264 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192009265 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192009266 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 760192009267 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192009268 catalytic loop [active] 760192009269 iron binding site [ion binding]; other site 760192009270 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 760192009271 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 760192009272 MG2 domain; Region: A2M_N; pfam01835 760192009273 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192009274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192009275 putative substrate translocation pore; other site 760192009276 Caspase domain; Region: Peptidase_C14; pfam00656 760192009277 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cl09941 760192009278 Ca2+ binding site [ion binding]; other site 760192009279 aldehyde dehydrogenase family 7 member; Region: PLN02315 760192009280 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 760192009281 tetrameric interface [polypeptide binding]; other site 760192009282 NAD binding site [chemical binding]; other site 760192009283 catalytic residues [active] 760192009284 Yqey-like protein; Region: YqeY; pfam09424 760192009285 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 760192009286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192009287 Walker A/P-loop; other site 760192009288 ATP binding site [chemical binding]; other site 760192009289 Q-loop/lid; other site 760192009290 ABC transporter signature motif; other site 760192009291 Walker B; other site 760192009292 D-loop; other site 760192009293 H-loop/switch region; other site 760192009294 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 760192009295 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 760192009296 FAD binding pocket [chemical binding]; other site 760192009297 FAD binding motif [chemical binding]; other site 760192009298 phosphate binding motif [ion binding]; other site 760192009299 beta-alpha-beta structure motif; other site 760192009300 NAD(p) ribose binding residues [chemical binding]; other site 760192009301 NAD binding pocket [chemical binding]; other site 760192009302 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 760192009303 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192009304 catalytic loop [active] 760192009305 iron binding site [ion binding]; other site 760192009306 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 760192009307 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 760192009308 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 760192009309 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 760192009310 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 760192009311 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 760192009312 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 760192009313 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 760192009314 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 760192009315 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 760192009316 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 760192009317 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 760192009318 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 760192009319 PhoH-like protein; Region: PhoH; pfam02562 760192009320 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 760192009321 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 760192009322 hinge; other site 760192009323 active site 760192009324 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 760192009325 PQQ-like domain; Region: PQQ_2; pfam13360 760192009326 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192009327 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 760192009328 endonuclease III; Region: ENDO3c; smart00478 760192009329 minor groove reading motif; other site 760192009330 helix-hairpin-helix signature motif; other site 760192009331 substrate binding pocket [chemical binding]; other site 760192009332 active site 760192009333 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 760192009334 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 760192009335 active site 760192009336 catalytic triad [active] 760192009337 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192009338 Plant calmodulin-binding domain; Region: CaM_binding; cl06741 760192009339 GldH lipoprotein; Region: GldH_lipo; cl11905 760192009340 chaperone protein DnaJ; Provisional; Region: PRK10767 760192009341 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 760192009342 HSP70 interaction site [polypeptide binding]; other site 760192009343 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 760192009344 substrate binding site [polypeptide binding]; other site 760192009345 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 760192009346 Zn binding sites [ion binding]; other site 760192009347 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 760192009348 dimer interface [polypeptide binding]; other site 760192009349 GrpE; Region: GrpE; pfam01025 760192009350 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 760192009351 dimer interface [polypeptide binding]; other site 760192009352 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 760192009353 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192009354 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192009355 catalytic residues [active] 760192009356 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 760192009357 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 760192009358 active site 760192009359 Substrate binding site; other site 760192009360 Mg++ binding site; other site 760192009361 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 760192009362 putative trimer interface [polypeptide binding]; other site 760192009363 putative CoA binding site [chemical binding]; other site 760192009364 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 760192009365 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 760192009366 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 760192009367 metal binding site [ion binding]; metal-binding site 760192009368 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 760192009369 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 760192009370 DNA binding site [nucleotide binding] 760192009371 active site 760192009372 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 760192009373 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 760192009374 G1 box; other site 760192009375 putative GEF interaction site [polypeptide binding]; other site 760192009376 GTP/Mg2+ binding site [chemical binding]; other site 760192009377 Switch I region; other site 760192009378 G2 box; other site 760192009379 G3 box; other site 760192009380 Switch II region; other site 760192009381 G4 box; other site 760192009382 G5 box; other site 760192009383 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 760192009384 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192009385 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192009386 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 760192009387 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 760192009388 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 760192009389 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 760192009390 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 760192009391 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 760192009392 Zn binding site [ion binding]; other site 760192009393 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 760192009394 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760192009395 Walker A/P-loop; other site 760192009396 ATP binding site [chemical binding]; other site 760192009397 Q-loop/lid; other site 760192009398 ABC transporter signature motif; other site 760192009399 Walker B; other site 760192009400 D-loop; other site 760192009401 H-loop/switch region; other site 760192009402 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 760192009403 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 760192009404 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192009405 ATP synthase subunit C; Region: ATP-synt_C; cl00466 760192009406 CotH protein; Region: CotH; pfam08757 760192009407 Lamin Tail Domain; Region: LTD; pfam00932 760192009408 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192009409 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 760192009410 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 760192009411 Domain of unknown function DUF21; Region: DUF21; pfam01595 760192009412 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 760192009413 Transporter associated domain; Region: CorC_HlyC; smart01091 760192009414 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 760192009415 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192009416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192009417 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 760192009418 Chromate transporter; Region: Chromate_transp; pfam02417 760192009419 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 760192009420 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 760192009421 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 760192009422 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192009423 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192009424 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192009425 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192009426 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192009427 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192009428 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 760192009429 Protein export membrane protein; Region: SecD_SecF; cl14618 760192009430 Outer membrane efflux protein; Region: OEP; pfam02321 760192009431 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 760192009432 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 760192009433 homodimer interface [polypeptide binding]; other site 760192009434 substrate-cofactor binding pocket; other site 760192009435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192009436 catalytic residue [active] 760192009437 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009438 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192009439 FtsX-like permease family; Region: FtsX; pfam02687 760192009440 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009441 FtsX-like permease family; Region: FtsX; pfam02687 760192009442 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009443 FtsX-like permease family; Region: FtsX; pfam02687 760192009444 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009445 FtsX-like permease family; Region: FtsX; pfam02687 760192009446 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192009447 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009448 FtsX-like permease family; Region: FtsX; pfam02687 760192009449 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192009450 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760192009451 Walker A/P-loop; other site 760192009452 ATP binding site [chemical binding]; other site 760192009453 Q-loop/lid; other site 760192009454 ABC transporter signature motif; other site 760192009455 Walker B; other site 760192009456 D-loop; other site 760192009457 H-loop/switch region; other site 760192009458 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192009459 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192009460 P-loop containing region of AAA domain; Region: AAA_29; cl17516 760192009461 AAA domain; Region: AAA_21; pfam13304 760192009462 putative oxidoreductase; Provisional; Region: PRK11579 760192009463 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192009464 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192009465 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 760192009466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 760192009467 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 760192009468 tyrosine decarboxylase; Region: PLN02880 760192009469 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192009470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192009471 catalytic residue [active] 760192009472 Sporulation related domain; Region: SPOR; pfam05036 760192009473 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 760192009474 putative hydrolase; Provisional; Region: PRK02113 760192009475 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192009476 exopolyphosphatase; Region: exo_poly_only; TIGR03706 760192009477 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 760192009478 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009479 FtsX-like permease family; Region: FtsX; pfam02687 760192009480 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009481 FtsX-like permease family; Region: FtsX; pfam02687 760192009482 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 760192009483 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 760192009484 active site 760192009485 FMN binding site [chemical binding]; other site 760192009486 2,4-decadienoyl-CoA binding site; other site 760192009487 catalytic residue [active] 760192009488 4Fe-4S cluster binding site [ion binding]; other site 760192009489 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 760192009490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192009491 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192009492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192009493 active site 760192009494 phosphorylation site [posttranslational modification] 760192009495 intermolecular recognition site; other site 760192009496 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192009497 DNA binding residues [nucleotide binding] 760192009498 dimerization interface [polypeptide binding]; other site 760192009499 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192009500 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192009501 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192009502 dockerin binding interface; other site 760192009503 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192009504 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 760192009505 dockerin binding interface; other site 760192009506 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 760192009507 dockerin binding interface; other site 760192009508 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 760192009509 dockerin binding interface; other site 760192009510 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192009511 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192009512 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192009513 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192009514 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192009515 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 760192009516 HYR domain; Region: HYR; pfam02494 760192009517 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192009518 dockerin binding interface; other site 760192009519 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192009520 hypothetical protein; Reviewed; Region: PRK12497 760192009521 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 760192009522 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192009523 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192009524 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192009525 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192009526 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192009527 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192009528 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 760192009529 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192009530 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 760192009531 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 760192009532 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 760192009533 active site 760192009534 homotetramer interface [polypeptide binding]; other site 760192009535 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 760192009536 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 760192009537 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 760192009538 putative transporter; Provisional; Region: PRK10484 760192009539 Na binding site [ion binding]; other site 760192009540 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192009541 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192009542 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192009543 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009544 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009545 FtsX-like permease family; Region: FtsX; pfam02687 760192009546 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 760192009547 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 760192009548 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 760192009549 active site 760192009550 Zn binding site [ion binding]; other site 760192009551 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192009552 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192009553 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192009554 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192009555 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192009556 non-specific DNA binding site [nucleotide binding]; other site 760192009557 salt bridge; other site 760192009558 sequence-specific DNA binding site [nucleotide binding]; other site 760192009559 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192009560 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192009561 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 760192009562 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192009563 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192009564 active site 760192009565 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192009566 von Willebrand factor; Region: vWF_A; pfam12450 760192009567 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 760192009568 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 760192009569 metal ion-dependent adhesion site (MIDAS); other site 760192009570 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 760192009571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760192009572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192009573 Coenzyme A binding pocket [chemical binding]; other site 760192009574 Uncharacterized conserved protein [Function unknown]; Region: COG2442 760192009575 Part of AAA domain; Region: AAA_19; pfam13245 760192009576 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 760192009577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192009578 Histidine kinase; Region: HisKA_3; pfam07730 760192009579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192009580 ATP binding site [chemical binding]; other site 760192009581 Mg2+ binding site [ion binding]; other site 760192009582 G-X-G motif; other site 760192009583 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192009584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192009585 active site 760192009586 phosphorylation site [posttranslational modification] 760192009587 intermolecular recognition site; other site 760192009588 dimerization interface [polypeptide binding]; other site 760192009589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192009590 DNA binding residues [nucleotide binding] 760192009591 dimerization interface [polypeptide binding]; other site 760192009592 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009593 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009594 FtsX-like permease family; Region: FtsX; pfam02687 760192009595 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192009596 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009597 FtsX-like permease family; Region: FtsX; pfam02687 760192009598 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009599 FtsX-like permease family; Region: FtsX; pfam02687 760192009600 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009601 FtsX-like permease family; Region: FtsX; pfam02687 760192009602 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009603 FtsX-like permease family; Region: FtsX; pfam02687 760192009604 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192009605 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192009606 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009607 FtsX-like permease family; Region: FtsX; pfam02687 760192009608 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 760192009609 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 760192009610 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009611 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192009612 FtsX-like permease family; Region: FtsX; pfam02687 760192009613 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009614 FtsX-like permease family; Region: FtsX; pfam02687 760192009615 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009616 FtsX-like permease family; Region: FtsX; pfam02687 760192009617 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009618 FtsX-like permease family; Region: FtsX; pfam02687 760192009619 Cupin domain; Region: Cupin_2; pfam07883 760192009620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192009621 AAA domain; Region: AAA_22; pfam13401 760192009622 Walker A motif; other site 760192009623 ATP binding site [chemical binding]; other site 760192009624 Walker B motif; other site 760192009625 arginine finger; other site 760192009626 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 760192009627 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 760192009628 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009629 FtsX-like permease family; Region: FtsX; pfam02687 760192009630 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009631 FtsX-like permease family; Region: FtsX; pfam02687 760192009632 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192009633 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009634 FtsX-like permease family; Region: FtsX; pfam02687 760192009635 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009636 FtsX-like permease family; Region: FtsX; pfam02687 760192009637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 760192009638 FtsX-like permease family; Region: FtsX; pfam02687 760192009639 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 760192009640 potential frameshift: common BLAST hit: gi|325104009|ref|YP_004273663.1| Domain of unknown function DUF1814 760192009641 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 760192009642 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 760192009643 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 760192009644 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 760192009645 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009646 FtsX-like permease family; Region: FtsX; pfam02687 760192009647 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009648 FtsX-like permease family; Region: FtsX; pfam02687 760192009649 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 760192009650 PA14 domain; Region: PA14; pfam07691 760192009651 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 760192009652 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 760192009653 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192009654 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192009655 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192009656 Putative esterase; Region: Esterase; pfam00756 760192009657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 760192009658 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 760192009659 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 760192009660 PIN domain; Region: PIN_2; cl17859 760192009661 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 760192009662 active site 760192009663 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192009664 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 760192009665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192009666 active site 760192009667 phosphorylation site [posttranslational modification] 760192009668 intermolecular recognition site; other site 760192009669 dimerization interface [polypeptide binding]; other site 760192009670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192009671 Walker A motif; other site 760192009672 ATP binding site [chemical binding]; other site 760192009673 Walker B motif; other site 760192009674 arginine finger; other site 760192009675 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760192009676 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192009677 Ligand Binding Site [chemical binding]; other site 760192009678 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192009679 Ligand Binding Site [chemical binding]; other site 760192009680 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 760192009681 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 760192009682 AAA-like domain; Region: AAA_10; pfam12846 760192009683 Winged helix-turn helix; Region: HTH_29; pfam13551 760192009684 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192009685 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 760192009686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192009687 Walker A/P-loop; other site 760192009688 ATP binding site [chemical binding]; other site 760192009689 putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183 760192009690 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 760192009691 Active Sites [active] 760192009692 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 760192009693 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 760192009694 nucleotide binding pocket [chemical binding]; other site 760192009695 K-X-D-G motif; other site 760192009696 catalytic site [active] 760192009697 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 760192009698 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192009699 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 760192009700 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 760192009701 putative acyl-acceptor binding pocket; other site 760192009702 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 760192009703 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 760192009704 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 760192009705 GxxExxY protein; Region: GxxExxY; TIGR04256 760192009706 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 760192009707 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 760192009708 oligomeric interface; other site 760192009709 putative active site [active] 760192009710 homodimer interface [polypeptide binding]; other site 760192009711 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 760192009712 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192009713 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192009714 protein binding site [polypeptide binding]; other site 760192009715 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 760192009716 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 760192009717 active site 760192009718 Zn binding site [ion binding]; other site 760192009719 Cytochrome c; Region: Cytochrom_C; pfam00034 760192009720 Anti-sigma-K factor rskA; Region: RskA; pfam10099 760192009721 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192009722 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192009723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192009724 DNA binding residues [nucleotide binding] 760192009725 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 760192009726 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 760192009727 substrate binding site; other site 760192009728 tetramer interface; other site 760192009729 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009730 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192009731 FtsX-like permease family; Region: FtsX; pfam02687 760192009732 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 760192009733 putative active site [active] 760192009734 putative CoA binding site [chemical binding]; other site 760192009735 nudix motif; other site 760192009736 metal binding site [ion binding]; metal-binding site 760192009737 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192009738 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192009739 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 760192009740 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 760192009741 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760192009742 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 760192009743 active site 760192009744 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760192009745 dimer interface [polypeptide binding]; other site 760192009746 substrate binding site [chemical binding]; other site 760192009747 catalytic residues [active] 760192009748 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 760192009749 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 760192009750 SurA N-terminal domain; Region: SurA_N; pfam09312 760192009751 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 760192009752 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 760192009753 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192009754 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 760192009755 active site 760192009756 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192009757 putative active site [active] 760192009758 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 760192009759 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192009760 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192009761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192009762 Q-loop/lid; other site 760192009763 ABC transporter signature motif; other site 760192009764 Walker B; other site 760192009765 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192009766 Caspase domain; Region: Peptidase_C14; pfam00656 760192009767 active site 760192009768 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 760192009769 active site 760192009770 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192009771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192009772 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192009773 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192009774 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192009775 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 760192009776 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 760192009777 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 760192009778 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192009779 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192009780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192009781 binding surface 760192009782 TPR motif; other site 760192009783 TPR repeat; Region: TPR_11; pfam13414 760192009784 MarR family; Region: MarR_2; cl17246 760192009785 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192009786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192009787 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 760192009788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 760192009789 active site 760192009790 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 760192009791 EamA-like transporter family; Region: EamA; pfam00892 760192009792 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 760192009793 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 760192009794 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 760192009795 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760192009796 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 760192009797 Peptidase family M1; Region: Peptidase_M1; pfam01433 760192009798 Zn binding site [ion binding]; other site 760192009799 HEAT repeats; Region: HEAT_2; pfam13646 760192009800 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 760192009801 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 760192009802 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 760192009803 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 760192009804 XisH protein; Region: XisH; pfam08814 760192009805 XisI protein; Region: XisI; pfam08869 760192009806 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192009807 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192009808 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 760192009809 putative lipid binding site [chemical binding]; other site 760192009810 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 760192009811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192009812 putative substrate translocation pore; other site 760192009813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192009814 Outer membrane protein Omp28; Region: Omp28; pfam11551 760192009815 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 760192009816 Putative zinc ribbon domain; Region: DUF164; pfam02591 760192009817 Uncharacterized conserved protein [Function unknown]; Region: COG0327 760192009818 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 760192009819 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 760192009820 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192009821 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192009822 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760192009823 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760192009824 protein binding site [polypeptide binding]; other site 760192009825 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 760192009826 Domain interface; other site 760192009827 Peptide binding site; other site 760192009828 Active site tetrad [active] 760192009829 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192009830 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 760192009831 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 760192009832 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 760192009833 RNA binding site [nucleotide binding]; other site 760192009834 transcription termination factor Rho; Provisional; Region: PRK12608 760192009835 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 760192009836 Walker A motif; other site 760192009837 ATP binding site [chemical binding]; other site 760192009838 Walker B motif; other site 760192009839 seryl-tRNA synthetase; Provisional; Region: PRK05431 760192009840 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 760192009841 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 760192009842 dimer interface [polypeptide binding]; other site 760192009843 active site 760192009844 motif 1; other site 760192009845 motif 2; other site 760192009846 motif 3; other site 760192009847 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 760192009848 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192009849 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192009850 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192009851 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 760192009852 thioester formation/cholesterol transfer; other site 760192009853 protein-splicing catalytic site; other site 760192009854 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 760192009855 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192009856 ribosome recycling factor; Reviewed; Region: frr; PRK00083 760192009857 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 760192009858 hinge region; other site 760192009859 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 760192009860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192009861 binding surface 760192009862 TPR motif; other site 760192009863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192009864 binding surface 760192009865 TPR motif; other site 760192009866 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 760192009867 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192009868 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192009869 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192009870 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192009871 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192009872 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760192009873 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 760192009874 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 760192009875 PemK-like protein; Region: PemK; pfam02452 760192009876 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 760192009877 MPN+ (JAMM) motif; other site 760192009878 Zinc-binding site [ion binding]; other site 760192009879 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760192009880 active site 760192009881 DNA binding site [nucleotide binding] 760192009882 Int/Topo IB signature motif; other site 760192009883 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 760192009884 VirE N-terminal domain; Region: VirE_N; pfam08800 760192009885 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 760192009886 Virulence-associated protein E; Region: VirE; pfam05272 760192009887 Helix-turn-helix domain; Region: HTH_17; cl17695 760192009888 Chloramphenicol acetyltransferase; Region: CAT; smart01059 760192009889 Repair protein; Region: Repair_PSII; pfam04536 760192009890 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 760192009891 MoaE homodimer interface [polypeptide binding]; other site 760192009892 MoaD interaction [polypeptide binding]; other site 760192009893 active site residues [active] 760192009894 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 760192009895 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 760192009896 putative active site [active] 760192009897 Zn binding site [ion binding]; other site 760192009898 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192009899 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192009900 catalytic residues [active] 760192009901 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192009902 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009903 FtsX-like permease family; Region: FtsX; pfam02687 760192009904 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009905 FtsX-like permease family; Region: FtsX; pfam02687 760192009906 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009907 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192009908 FtsX-like permease family; Region: FtsX; pfam02687 760192009909 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009910 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009911 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192009912 FtsX-like permease family; Region: FtsX; pfam02687 760192009913 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009914 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192009915 FtsX-like permease family; Region: FtsX; pfam02687 760192009916 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009917 FtsX-like permease family; Region: FtsX; pfam02687 760192009918 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009919 FtsX-like permease family; Region: FtsX; pfam02687 760192009920 Uncharacterized conserved protein [Function unknown]; Region: COG3391 760192009921 Cytochrome c; Region: Cytochrom_C; pfam00034 760192009922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 760192009923 Histidine kinase; Region: HisKA_2; pfam07568 760192009924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192009925 ATP binding site [chemical binding]; other site 760192009926 Mg2+ binding site [ion binding]; other site 760192009927 G-X-G motif; other site 760192009928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192009929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192009930 active site 760192009931 phosphorylation site [posttranslational modification] 760192009932 intermolecular recognition site; other site 760192009933 dimerization interface [polypeptide binding]; other site 760192009934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192009935 DNA binding residues [nucleotide binding] 760192009936 dimerization interface [polypeptide binding]; other site 760192009937 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 760192009938 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192009939 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009940 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192009941 FtsX-like permease family; Region: FtsX; pfam02687 760192009942 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009943 FtsX-like permease family; Region: FtsX; pfam02687 760192009944 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 760192009945 putative ligand binding site [chemical binding]; other site 760192009946 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 760192009947 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 760192009948 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192009949 putative active site [active] 760192009950 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 760192009951 putative catalytic site [active] 760192009952 putative metal binding site [ion binding]; other site 760192009953 putative phosphate binding site [ion binding]; other site 760192009954 TspO/MBR family; Region: TspO_MBR; pfam03073 760192009955 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192009956 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192009957 ligand binding site [chemical binding]; other site 760192009958 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 760192009959 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 760192009960 putative NAD(P) binding site [chemical binding]; other site 760192009961 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 760192009962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192009963 Walker A/P-loop; other site 760192009964 ATP binding site [chemical binding]; other site 760192009965 ABC transporter signature motif; other site 760192009966 Walker B; other site 760192009967 D-loop; other site 760192009968 H-loop/switch region; other site 760192009969 ABC transporter; Region: ABC_tran_2; pfam12848 760192009970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760192009971 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 760192009972 putative hydrophobic ligand binding site [chemical binding]; other site 760192009973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192009974 dimerization interface [polypeptide binding]; other site 760192009975 putative DNA binding site [nucleotide binding]; other site 760192009976 putative Zn2+ binding site [ion binding]; other site 760192009977 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 760192009978 hydrophobic ligand binding site; other site 760192009979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 760192009980 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 760192009981 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 760192009982 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192009983 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192009984 ligand binding site [chemical binding]; other site 760192009985 flexible hinge region; other site 760192009986 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 760192009987 YceI-like domain; Region: YceI; pfam04264 760192009988 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 760192009989 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 760192009990 FMN binding site [chemical binding]; other site 760192009991 substrate binding site [chemical binding]; other site 760192009992 putative catalytic residue [active] 760192009993 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192009994 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009995 FtsX-like permease family; Region: FtsX; pfam02687 760192009996 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192009997 FtsX-like permease family; Region: FtsX; pfam02687 760192009998 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 760192009999 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 760192010000 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192010001 FtsX-like permease family; Region: FtsX; pfam02687 760192010002 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192010003 FtsX-like permease family; Region: FtsX; pfam02687 760192010004 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192010005 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760192010006 FtsX-like permease family; Region: FtsX; pfam02687 760192010007 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192010008 FtsX-like permease family; Region: FtsX; pfam02687 760192010009 Protein of unknown function (DUF497); Region: DUF497; pfam04365 760192010010 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192010011 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192010012 ligand binding site [chemical binding]; other site 760192010013 flexible hinge region; other site 760192010014 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 760192010015 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 760192010016 putative NAD(P) binding site [chemical binding]; other site 760192010017 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192010018 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192010019 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 760192010020 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 760192010021 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 760192010022 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 760192010023 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192010024 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 760192010025 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 760192010026 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 760192010027 Methane oxygenase PmoA; Region: PmoA; pfam14100 760192010028 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192010029 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 760192010030 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192010031 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 760192010032 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 760192010033 Polyphenol oxidase middle domain; Region: PPO1_DWL; pfam12142 760192010034 Branched-chain amino acid ATP-binding cassette transporter; Region: BCA_ABC_TP_C; pfam12399 760192010035 Uncharacterized protein conserved in archaea (DUF2286); Region: DUF2286; cl02234 760192010036 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 760192010037 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 760192010038 substrate binding site [chemical binding]; other site 760192010039 dimer interface [polypeptide binding]; other site 760192010040 NADP binding site [chemical binding]; other site 760192010041 catalytic residues [active] 760192010042 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 760192010043 active site 2 [active] 760192010044 active site 1 [active] 760192010045 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 760192010046 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 760192010047 substrate binding site [chemical binding]; other site 760192010048 oxyanion hole (OAH) forming residues; other site 760192010049 trimer interface [polypeptide binding]; other site 760192010050 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 760192010051 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 760192010052 tetramer interface [polypeptide binding]; other site 760192010053 TPP-binding site [chemical binding]; other site 760192010054 heterodimer interface [polypeptide binding]; other site 760192010055 phosphorylation loop region [posttranslational modification] 760192010056 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 760192010057 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 760192010058 alpha subunit interface [polypeptide binding]; other site 760192010059 TPP binding site [chemical binding]; other site 760192010060 heterodimer interface [polypeptide binding]; other site 760192010061 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 760192010062 5,10-methenyltetrahydromethanopterin hydrogenase cofactor biosynthesis protein HmdC; Region: monoFe_hyd_HmdC; TIGR03958 760192010063 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 760192010064 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 760192010065 active site 760192010066 dimer interface [polypeptide binding]; other site 760192010067 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 760192010068 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 760192010069 ligand binding site; other site 760192010070 oligomer interface; other site 760192010071 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 760192010072 N-terminal domain interface [polypeptide binding]; other site 760192010073 sulfate 1 binding site; other site 760192010074 glycogen synthase; Provisional; Region: glgA; PRK00654 760192010075 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 760192010076 ADP-binding pocket [chemical binding]; other site 760192010077 homodimer interface [polypeptide binding]; other site 760192010078 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 760192010079 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 760192010080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 760192010081 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 760192010082 four helix bundle protein; Region: TIGR02436 760192010083 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 760192010084 Amidohydrolase; Region: Amidohydro_2; pfam04909 760192010085 short chain dehydrogenase; Provisional; Region: PRK08628 760192010086 classical (c) SDRs; Region: SDR_c; cd05233 760192010087 NAD(P) binding site [chemical binding]; other site 760192010088 active site 760192010089 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 760192010090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192010091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192010092 Domain of unknown function (DUF718); Region: DUF718; pfam05336 760192010093 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 760192010094 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 760192010095 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 760192010096 Amino acid permease; Region: AA_permease_2; pfam13520 760192010097 malate:quinone oxidoreductase; Validated; Region: PRK05257 760192010098 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 760192010099 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192010100 putative active site [active] 760192010101 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 760192010102 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 760192010103 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 760192010104 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 760192010105 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192010106 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 760192010107 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192010108 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 760192010109 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 760192010110 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 760192010111 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 760192010112 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192010113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192010114 catalytic residue [active] 760192010115 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 760192010116 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 760192010117 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 760192010118 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 760192010119 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 760192010120 Family description; Region: VCBS; pfam13517 760192010121 Family description; Region: VCBS; pfam13517 760192010122 Family description; Region: VCBS; pfam13517 760192010123 Family description; Region: VCBS; pfam13517 760192010124 Family description; Region: VCBS; pfam13517 760192010125 Family description; Region: VCBS; pfam13517 760192010126 Family description; Region: VCBS; pfam13517 760192010127 Family description; Region: VCBS; pfam13517 760192010128 Family description; Region: VCBS; pfam13517 760192010129 Family description; Region: VCBS; pfam13517 760192010130 Family description; Region: VCBS; pfam13517 760192010131 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 760192010132 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 760192010133 acyl-activating enzyme (AAE) consensus motif; other site 760192010134 putative AMP binding site [chemical binding]; other site 760192010135 putative active site [active] 760192010136 putative CoA binding site [chemical binding]; other site 760192010137 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 760192010138 IHF dimer interface [polypeptide binding]; other site 760192010139 IHF - DNA interface [nucleotide binding]; other site 760192010140 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192010141 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 760192010142 dimer interface [polypeptide binding]; other site 760192010143 substrate binding site [chemical binding]; other site 760192010144 metal binding site [ion binding]; metal-binding site 760192010145 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 760192010146 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 760192010147 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760192010148 active site 760192010149 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 760192010150 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 760192010151 5S rRNA interface [nucleotide binding]; other site 760192010152 CTC domain interface [polypeptide binding]; other site 760192010153 L16 interface [polypeptide binding]; other site 760192010154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192010155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192010156 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 760192010157 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 760192010158 Bacterial Ig-like domain; Region: Big_5; pfam13205 760192010159 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192010160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 760192010161 Putative glucoamylase; Region: Glycoamylase; pfam10091 760192010162 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 760192010163 Ferritin-like domain; Region: Ferritin; pfam00210 760192010164 ferroxidase diiron center [ion binding]; other site 760192010165 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 760192010166 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192010167 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192010168 YceI-like domain; Region: YceI; pfam04264 760192010169 thymidine kinase; Provisional; Region: PRK04296 760192010170 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760192010171 M28 Zn-Peptidases; Region: M28_like_4; cd08015 760192010172 Peptidase family M28; Region: Peptidase_M28; pfam04389 760192010173 metal binding site [ion binding]; metal-binding site 760192010174 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 760192010175 putative active site [active] 760192010176 putative catalytic site [active] 760192010177 putative DNA binding site [nucleotide binding]; other site 760192010178 putative phosphate binding site [ion binding]; other site 760192010179 metal binding site A [ion binding]; metal-binding site 760192010180 putative AP binding site [nucleotide binding]; other site 760192010181 putative metal binding site B [ion binding]; other site 760192010182 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 760192010183 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 760192010184 FAD binding pocket [chemical binding]; other site 760192010185 conserved FAD binding motif [chemical binding]; other site 760192010186 phosphate binding motif [ion binding]; other site 760192010187 beta-alpha-beta structure motif; other site 760192010188 NAD binding pocket [chemical binding]; other site 760192010189 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 760192010190 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 760192010191 homodimer interface [polypeptide binding]; other site 760192010192 catalytic residues [active] 760192010193 NAD binding site [chemical binding]; other site 760192010194 substrate binding pocket [chemical binding]; other site 760192010195 flexible flap; other site 760192010196 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 760192010197 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 760192010198 phosphate binding site [ion binding]; other site 760192010199 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 760192010200 nudix motif; other site 760192010201 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 760192010202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 760192010203 Coenzyme A binding pocket [chemical binding]; other site 760192010204 argininosuccinate synthase; Provisional; Region: PRK13820 760192010205 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 760192010206 Ligand Binding Site [chemical binding]; other site 760192010207 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 760192010208 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 760192010209 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 760192010210 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192010211 inhibitor-cofactor binding pocket; inhibition site 760192010212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192010213 catalytic residue [active] 760192010214 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 760192010215 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 760192010216 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 760192010217 XisI protein; Region: XisI; pfam08869 760192010218 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 760192010219 Predicted transcriptional regulator [Transcription]; Region: COG3655 760192010220 salt bridge; other site 760192010221 non-specific DNA binding site [nucleotide binding]; other site 760192010222 sequence-specific DNA binding site [nucleotide binding]; other site 760192010223 Cupin domain; Region: Cupin_2; pfam07883 760192010224 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192010225 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 760192010226 active site 760192010227 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 760192010228 Acyltransferase family; Region: Acyl_transf_3; pfam01757 760192010229 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 760192010230 putative hydrophobic ligand binding site [chemical binding]; other site 760192010231 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192010232 Response regulator receiver domain; Region: Response_reg; pfam00072 760192010233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192010234 active site 760192010235 phosphorylation site [posttranslational modification] 760192010236 intermolecular recognition site; other site 760192010237 dimerization interface [polypeptide binding]; other site 760192010238 two-component response regulator; Provisional; Region: PRK14084 760192010239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192010240 active site 760192010241 phosphorylation site [posttranslational modification] 760192010242 intermolecular recognition site; other site 760192010243 dimerization interface [polypeptide binding]; other site 760192010244 LytTr DNA-binding domain; Region: LytTR; smart00850 760192010245 PAS domain S-box; Region: sensory_box; TIGR00229 760192010246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192010247 putative active site [active] 760192010248 heme pocket [chemical binding]; other site 760192010249 PAS fold; Region: PAS_7; pfam12860 760192010250 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760192010251 Histidine kinase; Region: His_kinase; pfam06580 760192010252 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 760192010253 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 760192010254 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 760192010255 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192010256 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 760192010257 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 760192010258 conserved cys residue [active] 760192010259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192010260 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192010261 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192010262 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 760192010263 active site triad [active] 760192010264 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192010265 Domain of unknown function (DU1801); Region: DUF1801; cl17490 760192010266 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192010267 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 760192010268 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192010269 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 760192010270 dockerin binding interface; other site 760192010271 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192010272 Uncharacterized conserved protein [Function unknown]; Region: COG5470 760192010273 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192010274 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192010275 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 760192010276 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192010277 active site 760192010278 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192010279 Family description; Region: VCBS; pfam13517 760192010280 Family description; Region: VCBS; pfam13517 760192010281 Family description; Region: VCBS; pfam13517 760192010282 Family description; Region: VCBS; pfam13517 760192010283 Family description; Region: VCBS; pfam13517 760192010284 Family description; Region: VCBS; pfam13517 760192010285 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 760192010286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192010287 TIGR01777 family protein; Region: yfcH 760192010288 NAD(P) binding site [chemical binding]; other site 760192010289 active site 760192010290 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 760192010291 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 760192010292 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 760192010293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760192010294 dimer interface [polypeptide binding]; other site 760192010295 conserved gate region; other site 760192010296 putative PBP binding loops; other site 760192010297 ABC-ATPase subunit interface; other site 760192010298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760192010299 dimer interface [polypeptide binding]; other site 760192010300 conserved gate region; other site 760192010301 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 760192010302 putative PBP binding loops; other site 760192010303 ABC-ATPase subunit interface; other site 760192010304 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192010305 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192010306 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192010307 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192010308 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 760192010309 Alkaline phosphatase homologues; Region: alkPPc; smart00098 760192010310 active site 760192010311 dimer interface [polypeptide binding]; other site 760192010312 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 760192010313 DNA protecting protein DprA; Region: dprA; TIGR00732 760192010314 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 760192010315 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 760192010316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760192010317 Zn2+ binding site [ion binding]; other site 760192010318 Mg2+ binding site [ion binding]; other site 760192010319 Response regulator receiver domain; Region: Response_reg; pfam00072 760192010320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192010321 active site 760192010322 phosphorylation site [posttranslational modification] 760192010323 intermolecular recognition site; other site 760192010324 dimerization interface [polypeptide binding]; other site 760192010325 PglZ domain; Region: PglZ; pfam08665 760192010326 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 760192010327 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 760192010328 Carboxylesterase family; Region: COesterase; pfam00135 760192010329 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192010330 substrate binding pocket [chemical binding]; other site 760192010331 catalytic triad [active] 760192010332 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 760192010333 EamA-like transporter family; Region: EamA; pfam00892 760192010334 EamA-like transporter family; Region: EamA; pfam00892 760192010335 Predicted membrane protein [Function unknown]; Region: COG4818 760192010336 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 760192010337 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 760192010338 putative ATP binding site [chemical binding]; other site 760192010339 putative substrate interface [chemical binding]; other site 760192010340 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192010341 active site 760192010342 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760192010343 active site 760192010344 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 760192010345 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192010346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192010347 Histidine kinase; Region: HisKA_3; pfam07730 760192010348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192010349 ATP binding site [chemical binding]; other site 760192010350 Mg2+ binding site [ion binding]; other site 760192010351 G-X-G motif; other site 760192010352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192010353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192010354 active site 760192010355 phosphorylation site [posttranslational modification] 760192010356 intermolecular recognition site; other site 760192010357 dimerization interface [polypeptide binding]; other site 760192010358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192010359 DNA binding residues [nucleotide binding] 760192010360 dimerization interface [polypeptide binding]; other site 760192010361 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 760192010362 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192010363 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 760192010364 putative active site [active] 760192010365 putative NTP binding site [chemical binding]; other site 760192010366 putative nucleic acid binding site [nucleotide binding]; other site 760192010367 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 760192010368 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 760192010369 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192010370 putative active site [active] 760192010371 heme pocket [chemical binding]; other site 760192010372 Histidine kinase; Region: HisKA_3; pfam07730 760192010373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192010374 ATP binding site [chemical binding]; other site 760192010375 Mg2+ binding site [ion binding]; other site 760192010376 G-X-G motif; other site 760192010377 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 760192010378 nitrite reductase subunit NirD; Provisional; Region: PRK14989 760192010379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192010380 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192010381 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 760192010382 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 760192010383 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 760192010384 active site 760192010385 SAM binding site [chemical binding]; other site 760192010386 homodimer interface [polypeptide binding]; other site 760192010387 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 760192010388 Peptidase family M48; Region: Peptidase_M48; pfam01435 760192010389 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 760192010390 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 760192010391 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 760192010392 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 760192010393 homodimer interface [polypeptide binding]; other site 760192010394 metal binding site [ion binding]; metal-binding site 760192010395 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 760192010396 homodimer interface [polypeptide binding]; other site 760192010397 active site 760192010398 putative chemical substrate binding site [chemical binding]; other site 760192010399 metal binding site [ion binding]; metal-binding site 760192010400 CoA binding domain; Region: CoA_binding_2; pfam13380 760192010401 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 760192010402 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 760192010403 E3 interaction surface; other site 760192010404 lipoyl attachment site [posttranslational modification]; other site 760192010405 e3 binding domain; Region: E3_binding; pfam02817 760192010406 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 760192010407 recombination protein RecR; Reviewed; Region: recR; PRK00076 760192010408 RecR protein; Region: RecR; pfam02132 760192010409 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 760192010410 putative active site [active] 760192010411 putative metal-binding site [ion binding]; other site 760192010412 tetramer interface [polypeptide binding]; other site 760192010413 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 760192010414 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 760192010415 Probable Catalytic site; other site 760192010416 metal-binding site 760192010417 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192010418 tyrosine decarboxylase; Region: PLN02880 760192010419 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192010420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192010421 catalytic residue [active] 760192010422 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192010423 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192010424 Trehalase; Region: Trehalase; cl17346 760192010425 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 760192010426 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 760192010427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192010428 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 760192010429 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 760192010430 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 760192010431 TPP-binding site [chemical binding]; other site 760192010432 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 760192010433 dimer interface [polypeptide binding]; other site 760192010434 PYR/PP interface [polypeptide binding]; other site 760192010435 TPP binding site [chemical binding]; other site 760192010436 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 760192010437 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192010438 hypothetical protein; Validated; Region: PRK00153 760192010439 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 760192010440 aspartate kinase III; Validated; Region: PRK09084 760192010441 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 760192010442 nucleotide binding site [chemical binding]; other site 760192010443 substrate binding site [chemical binding]; other site 760192010444 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 760192010445 dimer interface [polypeptide binding]; other site 760192010446 allosteric regulatory binding pocket; other site 760192010447 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 760192010448 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 760192010449 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 760192010450 purine monophosphate binding site [chemical binding]; other site 760192010451 dimer interface [polypeptide binding]; other site 760192010452 putative catalytic residues [active] 760192010453 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 760192010454 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 760192010455 Type III pantothenate kinase; Region: Pan_kinase; cl17198 760192010456 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 760192010457 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192010458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192010459 Walker A/P-loop; other site 760192010460 ATP binding site [chemical binding]; other site 760192010461 Q-loop/lid; other site 760192010462 ABC transporter signature motif; other site 760192010463 Walker B; other site 760192010464 D-loop; other site 760192010465 H-loop/switch region; other site 760192010466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 760192010467 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192010468 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192010469 ligand binding site [chemical binding]; other site 760192010470 DinB superfamily; Region: DinB_2; pfam12867 760192010471 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 760192010472 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192010473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192010474 active site 760192010475 phosphorylation site [posttranslational modification] 760192010476 intermolecular recognition site; other site 760192010477 dimerization interface [polypeptide binding]; other site 760192010478 LytTr DNA-binding domain; Region: LytTR; smart00850 760192010479 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760192010480 Histidine kinase; Region: His_kinase; pfam06580 760192010481 hypothetical protein; Provisional; Region: yieM; PRK10997 760192010482 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 760192010483 metal ion-dependent adhesion site (MIDAS); other site 760192010484 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 760192010485 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 760192010486 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 760192010487 XisH protein; Region: XisH; pfam08814 760192010488 XisI protein; Region: XisI; pfam08869 760192010489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192010490 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192010491 Walker A motif; other site 760192010492 ATP binding site [chemical binding]; other site 760192010493 Walker B motif; other site 760192010494 arginine finger; other site 760192010495 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 760192010496 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760192010497 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192010498 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192010499 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192010500 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192010501 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192010502 active site 760192010503 catalytic tetrad [active] 760192010504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760192010505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760192010506 DNA binding site [nucleotide binding] 760192010507 domain linker motif; other site 760192010508 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760192010509 dimerization interface [polypeptide binding]; other site 760192010510 ligand binding site [chemical binding]; other site 760192010511 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 760192010512 putative metal binding site [ion binding]; other site 760192010513 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 760192010514 active site 760192010515 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 760192010516 putative substrate binding site [chemical binding]; other site 760192010517 active site 760192010518 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 760192010519 N-acetyl-D-glucosamine binding site [chemical binding]; other site 760192010520 catalytic residue [active] 760192010521 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 760192010522 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 760192010523 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 760192010524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 760192010525 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 760192010526 methionine synthase; Provisional; Region: PRK01207 760192010527 substrate binding site [chemical binding]; other site 760192010528 THF binding site; other site 760192010529 zinc-binding site [ion binding]; other site 760192010530 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 760192010531 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 760192010532 active site 760192010533 catalytic site [active] 760192010534 substrate binding site [chemical binding]; other site 760192010535 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 760192010536 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 760192010537 homodimer interface [polypeptide binding]; other site 760192010538 substrate-cofactor binding pocket; other site 760192010539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192010540 catalytic residue [active] 760192010541 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 760192010542 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 760192010543 putative active site [active] 760192010544 catalytic triad [active] 760192010545 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 760192010546 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 760192010547 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 760192010548 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 760192010549 carboxyltransferase (CT) interaction site; other site 760192010550 biotinylation site [posttranslational modification]; other site 760192010551 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 760192010552 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 760192010553 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192010554 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 760192010555 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192010556 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192010557 catalytic residues [active] 760192010558 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 760192010559 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192010560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192010561 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 760192010562 putative active site [active] 760192010563 heme pocket [chemical binding]; other site 760192010564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192010565 putative active site [active] 760192010566 heme pocket [chemical binding]; other site 760192010567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192010568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192010569 dimer interface [polypeptide binding]; other site 760192010570 phosphorylation site [posttranslational modification] 760192010571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192010572 ATP binding site [chemical binding]; other site 760192010573 Mg2+ binding site [ion binding]; other site 760192010574 G-X-G motif; other site 760192010575 Response regulator receiver domain; Region: Response_reg; pfam00072 760192010576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192010577 active site 760192010578 phosphorylation site [posttranslational modification] 760192010579 intermolecular recognition site; other site 760192010580 dimerization interface [polypeptide binding]; other site 760192010581 Hpt domain; Region: Hpt; pfam01627 760192010582 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192010583 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192010584 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192010585 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192010586 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192010587 short chain dehydrogenase; Validated; Region: PRK06182 760192010588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192010589 NAD(P) binding site [chemical binding]; other site 760192010590 active site 760192010591 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 760192010592 AAA ATPase domain; Region: AAA_16; pfam13191 760192010593 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192010594 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192010595 HRDC domain; Region: HRDC; pfam00570 760192010596 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 760192010597 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192010598 putative active site [active] 760192010599 putative NTP binding site [chemical binding]; other site 760192010600 putative nucleic acid binding site [nucleotide binding]; other site 760192010601 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760192010602 LytTr DNA-binding domain; Region: LytTR; smart00850 760192010603 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 760192010604 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 760192010605 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 760192010606 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 760192010607 putative active site [active] 760192010608 putative substrate binding site [chemical binding]; other site 760192010609 putative cosubstrate binding site; other site 760192010610 catalytic site [active] 760192010611 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192010612 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192010613 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192010614 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192010615 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 760192010616 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 760192010617 Sporulation related domain; Region: SPOR; pfam05036 760192010618 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192010619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192010620 non-specific DNA binding site [nucleotide binding]; other site 760192010621 salt bridge; other site 760192010622 sequence-specific DNA binding site [nucleotide binding]; other site 760192010623 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192010624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192010625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192010626 DNA binding residues [nucleotide binding] 760192010627 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 760192010628 active site 760192010629 catalytic triad [active] 760192010630 Sporulation related domain; Region: SPOR; pfam05036 760192010631 Type III pantothenate kinase; Region: Pan_kinase; cl17198 760192010632 Acylphosphatase; Region: Acylphosphatase; pfam00708 760192010633 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 760192010634 HypF finger; Region: zf-HYPF; pfam07503 760192010635 HypF finger; Region: zf-HYPF; pfam07503 760192010636 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 760192010637 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 760192010638 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 760192010639 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 760192010640 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 760192010641 dimerization interface [polypeptide binding]; other site 760192010642 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 760192010643 ATP binding site [chemical binding]; other site 760192010644 High-affinity nickel-transport protein; Region: NicO; cl00964 760192010645 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 760192010646 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 760192010647 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 760192010648 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 760192010649 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 760192010650 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 760192010651 putative active site [active] 760192010652 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192010653 Domain of unknown function (DUF718); Region: DUF718; pfam05336 760192010654 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 760192010655 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192010656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192010657 active site 760192010658 phosphorylation site [posttranslational modification] 760192010659 intermolecular recognition site; other site 760192010660 dimerization interface [polypeptide binding]; other site 760192010661 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192010662 DNA binding residues [nucleotide binding] 760192010663 dimerization interface [polypeptide binding]; other site 760192010664 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192010665 Two component regulator propeller; Region: Reg_prop; pfam07494 760192010666 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192010667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192010668 Histidine kinase; Region: HisKA_3; pfam07730 760192010669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192010670 ATP binding site [chemical binding]; other site 760192010671 Mg2+ binding site [ion binding]; other site 760192010672 G-X-G motif; other site 760192010673 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 760192010674 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 760192010675 Citrate transporter; Region: CitMHS; pfam03600 760192010676 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 760192010677 BNR repeat-like domain; Region: BNR_2; pfam13088 760192010678 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 760192010679 Asp-box motif; other site 760192010680 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 760192010681 Na binding site [ion binding]; other site 760192010682 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010683 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 760192010684 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010685 Leucine-rich repeats; other site 760192010686 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010687 Substrate binding site [chemical binding]; other site 760192010688 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010689 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010690 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010691 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 760192010692 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010693 Leucine-rich repeats; other site 760192010694 Substrate binding site [chemical binding]; other site 760192010695 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010696 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010697 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010698 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010699 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010700 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010701 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192010702 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 760192010703 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192010704 G1 box; other site 760192010705 GTP/Mg2+ binding site [chemical binding]; other site 760192010706 G2 box; other site 760192010707 Switch I region; other site 760192010708 G3 box; other site 760192010709 Switch II region; other site 760192010710 G4 box; other site 760192010711 G5 box; other site 760192010712 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192010713 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192010714 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192010715 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760192010716 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760192010717 DNA binding site [nucleotide binding] 760192010718 domain linker motif; other site 760192010719 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760192010720 ligand binding site [chemical binding]; other site 760192010721 dimerization interface [polypeptide binding]; other site 760192010722 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192010723 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192010724 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192010725 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192010726 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192010727 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 760192010728 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 760192010729 active site 760192010730 Pectate lyase; Region: Pec_lyase_C; cl01593 760192010731 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192010732 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 760192010733 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 760192010734 NADP binding site [chemical binding]; other site 760192010735 homodimer interface [polypeptide binding]; other site 760192010736 active site 760192010737 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 760192010738 Pectic acid lyase; Region: Pec_lyase; pfam09492 760192010739 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 760192010740 active site 760192010741 catalytic triad [active] 760192010742 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 760192010743 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 760192010744 Abhydrolase family; Region: Abhydrolase_7; pfam12715 760192010745 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 760192010746 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192010747 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 760192010748 dockerin binding interface; other site 760192010749 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192010750 CHAT domain; Region: CHAT; cl17868 760192010751 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 760192010752 putative active site [active] 760192010753 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 760192010754 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 760192010755 putative pectinesterase; Region: PLN02432; cl01911 760192010756 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 760192010757 altronate oxidoreductase; Provisional; Region: PRK03643 760192010758 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 760192010759 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 760192010760 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 760192010761 galactarate dehydratase; Region: galactar-dH20; TIGR03248 760192010762 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 760192010763 Glucuronate isomerase; Region: UxaC; pfam02614 760192010764 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 760192010765 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760192010766 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 760192010767 substrate binding site [chemical binding]; other site 760192010768 ATP binding site [chemical binding]; other site 760192010769 Entner-Doudoroff aldolase; Region: eda; TIGR01182 760192010770 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 760192010771 active site 760192010772 intersubunit interface [polypeptide binding]; other site 760192010773 catalytic residue [active] 760192010774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192010775 putative substrate translocation pore; other site 760192010776 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 760192010777 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 760192010778 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 760192010779 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192010780 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 760192010781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192010782 binding surface 760192010783 TPR motif; other site 760192010784 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192010786 binding surface 760192010787 TPR motif; other site 760192010788 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010789 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192010791 binding surface 760192010792 TPR motif; other site 760192010793 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010794 CHAT domain; Region: CHAT; pfam12770 760192010795 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192010797 binding surface 760192010798 TPR motif; other site 760192010799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192010800 binding surface 760192010801 TPR motif; other site 760192010802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010803 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192010805 binding surface 760192010806 TPR motif; other site 760192010807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010809 CHAT domain; Region: CHAT; pfam12770 760192010810 Protein of unknown function (DUF418); Region: DUF418; cl12135 760192010811 Protein of unknown function (DUF418); Region: DUF418; pfam04235 760192010812 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760192010813 TPR repeat; Region: TPR_11; pfam13414 760192010814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192010815 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192010816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192010817 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 760192010818 active site 760192010819 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192010820 Predicted membrane protein [Function unknown]; Region: COG2311 760192010821 Protein of unknown function (DUF418); Region: DUF418; cl12135 760192010822 Protein of unknown function (DUF418); Region: DUF418; pfam04235 760192010823 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 760192010824 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 760192010825 active site 760192010826 Cytochrome c; Region: Cytochrom_C; pfam00034 760192010827 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192010828 active site residue [active] 760192010829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192010830 TPR motif; other site 760192010831 TPR repeat; Region: TPR_11; pfam13414 760192010832 binding surface 760192010833 Predicted membrane protein [Function unknown]; Region: COG2311 760192010834 Protein of unknown function (DUF418); Region: DUF418; cl12135 760192010835 Protein of unknown function (DUF418); Region: DUF418; pfam04235 760192010836 active site 760192010837 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 760192010838 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 760192010839 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 760192010840 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 760192010841 Transposase IS200 like; Region: Y1_Tnp; cl00848 760192010842 Transposase IS200 like; Region: Y1_Tnp; cl00848 760192010843 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192010844 EthD domain; Region: EthD; cl17553 760192010845 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 760192010846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192010847 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192010848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192010849 Walker A motif; other site 760192010850 ATP binding site [chemical binding]; other site 760192010851 Walker B motif; other site 760192010852 arginine finger; other site 760192010853 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 760192010854 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 760192010855 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 760192010856 FMN-binding domain; Region: FMN_bind; cl01081 760192010857 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 760192010858 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 760192010859 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 760192010860 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 760192010861 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192010862 catalytic loop [active] 760192010863 iron binding site [ion binding]; other site 760192010864 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 760192010865 FAD binding pocket [chemical binding]; other site 760192010866 FAD binding motif [chemical binding]; other site 760192010867 phosphate binding motif [ion binding]; other site 760192010868 beta-alpha-beta structure motif; other site 760192010869 NAD binding pocket [chemical binding]; other site 760192010870 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192010871 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192010872 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192010873 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192010874 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192010875 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192010876 Bifunctional nuclease; Region: DNase-RNase; pfam02577 760192010877 UvrB/uvrC motif; Region: UVR; pfam02151 760192010878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192010879 AAA domain; Region: AAA_22; pfam13401 760192010880 Walker A motif; other site 760192010881 ATP binding site [chemical binding]; other site 760192010882 Walker B motif; other site 760192010883 arginine finger; other site 760192010884 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 760192010885 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 760192010886 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 760192010887 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 760192010888 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 760192010889 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 760192010890 Phage Tail Collar Domain; Region: Collar; pfam07484 760192010891 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192010892 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192010893 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192010894 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192010895 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192010896 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192010897 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192010898 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192010899 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192010900 AAA domain; Region: AAA_28; pfam13521 760192010901 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 760192010902 GTPase Era; Reviewed; Region: era; PRK00089 760192010903 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 760192010904 G1 box; other site 760192010905 GTP/Mg2+ binding site [chemical binding]; other site 760192010906 Switch I region; other site 760192010907 G2 box; other site 760192010908 Switch II region; other site 760192010909 G3 box; other site 760192010910 G4 box; other site 760192010911 G5 box; other site 760192010912 KH domain; Region: KH_2; pfam07650 760192010913 Electron transfer DM13; Region: DM13; pfam10517 760192010914 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 760192010915 putative hydrophobic ligand binding site [chemical binding]; other site 760192010916 Two component regulator propeller; Region: Reg_prop; pfam07494 760192010917 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 760192010918 TPR repeat; Region: TPR_11; pfam13414 760192010919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192010920 binding surface 760192010921 TPR repeat; Region: TPR_11; pfam13414 760192010922 TPR motif; other site 760192010923 TPR repeat; Region: TPR_11; pfam13414 760192010924 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192010925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192010926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192010927 Bacterial transcriptional repressor; Region: TetR; pfam13972 760192010928 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 760192010929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192010930 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 760192010931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 760192010932 NAD(P) binding site [chemical binding]; other site 760192010933 substrate binding site [chemical binding]; other site 760192010934 homotetramer interface [polypeptide binding]; other site 760192010935 active site 760192010936 homodimer interface [polypeptide binding]; other site 760192010937 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 760192010938 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 760192010939 acyl-activating enzyme (AAE) consensus motif; other site 760192010940 putative AMP binding site [chemical binding]; other site 760192010941 putative active site [active] 760192010942 putative CoA binding site [chemical binding]; other site 760192010943 short chain dehydrogenase; Provisional; Region: PRK06181 760192010944 classical (c) SDRs; Region: SDR_c; cd05233 760192010945 NAD(P) binding site [chemical binding]; other site 760192010946 active site 760192010947 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 760192010948 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 760192010949 NAD(P) binding site [chemical binding]; other site 760192010950 catalytic residues [active] 760192010951 Sporulation related domain; Region: SPOR; pfam05036 760192010952 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 760192010953 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 760192010954 Competence protein; Region: Competence; pfam03772 760192010955 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 760192010956 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 760192010957 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 760192010958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 760192010959 S-adenosylmethionine synthetase; Validated; Region: PRK05250 760192010960 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 760192010961 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 760192010962 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 760192010963 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 760192010964 nucleoside/Zn binding site; other site 760192010965 dimer interface [polypeptide binding]; other site 760192010966 catalytic motif [active] 760192010967 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 760192010968 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 760192010969 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 760192010970 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 760192010971 active site 760192010972 HIGH motif; other site 760192010973 dimer interface [polypeptide binding]; other site 760192010974 KMSKS motif; other site 760192010975 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 760192010976 homotrimer interaction site [polypeptide binding]; other site 760192010977 putative active site [active] 760192010978 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 760192010979 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 760192010980 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192010981 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192010982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 760192010983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192010984 S-adenosylmethionine binding site [chemical binding]; other site 760192010985 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 760192010986 hypothetical protein; Provisional; Region: PRK10621 760192010987 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 760192010988 active site 760192010989 catalytic site [active] 760192010990 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 760192010991 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192010992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192010993 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192010994 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 760192010995 hypothetical protein; Validated; Region: PRK00041 760192010996 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 760192010997 dimer interface [polypeptide binding]; other site 760192010998 allosteric magnesium binding site [ion binding]; other site 760192010999 active site 760192011000 aspartate-rich active site metal binding site; other site 760192011001 Schiff base residues; other site 760192011002 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 760192011003 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 760192011004 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 760192011005 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760192011006 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 760192011007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192011008 motif II; other site 760192011009 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 760192011010 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 760192011011 RNA polymerase sigma factor; Provisional; Region: PRK12513 760192011012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192011013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192011014 DNA binding residues [nucleotide binding] 760192011015 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 760192011016 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760192011017 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760192011018 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 760192011019 Bor protein; Region: Lambda_Bor; pfam06291 760192011020 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 760192011021 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 760192011022 NAD(P) binding site [chemical binding]; other site 760192011023 homotetramer interface [polypeptide binding]; other site 760192011024 homodimer interface [polypeptide binding]; other site 760192011025 active site 760192011026 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 760192011027 DinB superfamily; Region: DinB_2; pfam12867 760192011028 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 760192011029 active site 760192011030 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192011031 Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_3; cd04327 760192011032 active site 760192011033 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192011034 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192011035 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192011036 ligand binding site [chemical binding]; other site 760192011037 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 760192011038 hydrophobic ligand binding site; other site 760192011039 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192011040 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192011041 ligand binding site [chemical binding]; other site 760192011042 flexible hinge region; other site 760192011043 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 760192011044 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 760192011045 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 760192011046 Walker A/P-loop; other site 760192011047 ATP binding site [chemical binding]; other site 760192011048 Q-loop/lid; other site 760192011049 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 760192011050 ABC transporter signature motif; other site 760192011051 Walker B; other site 760192011052 D-loop; other site 760192011053 H-loop/switch region; other site 760192011054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192011055 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 760192011056 NAD(P) binding site [chemical binding]; other site 760192011057 active site 760192011058 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 760192011059 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192011060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192011061 non-specific DNA binding site [nucleotide binding]; other site 760192011062 salt bridge; other site 760192011063 sequence-specific DNA binding site [nucleotide binding]; other site 760192011064 Cupin domain; Region: Cupin_2; pfam07883 760192011065 Penicillin amidase; Region: Penicil_amidase; pfam01804 760192011066 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 760192011067 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 760192011068 active site 760192011069 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 760192011070 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 760192011071 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192011072 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192011073 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192011074 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 760192011075 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 760192011076 putative metal binding site [ion binding]; other site 760192011077 GxxExxY protein; Region: GxxExxY; TIGR04256 760192011078 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 760192011079 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 760192011080 Domain of unknown function (DUF303); Region: DUF303; pfam03629 760192011081 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192011082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 760192011083 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 760192011084 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011085 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 760192011086 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 760192011087 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 760192011088 active site 760192011089 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 760192011090 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 760192011091 Catalytic site [active] 760192011092 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 760192011093 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 760192011094 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 760192011095 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192011096 putative active site [active] 760192011097 putative metal binding site [ion binding]; other site 760192011098 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 760192011099 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 760192011100 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 760192011101 Predicted membrane protein [Function unknown]; Region: COG2259 760192011102 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192011103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192011104 active site 760192011105 phosphorylation site [posttranslational modification] 760192011106 intermolecular recognition site; other site 760192011107 dimerization interface [polypeptide binding]; other site 760192011108 LytTr DNA-binding domain; Region: LytTR; smart00850 760192011109 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011110 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 760192011111 nudix motif; other site 760192011112 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 760192011113 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192011114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192011115 active site 760192011116 phosphorylation site [posttranslational modification] 760192011117 intermolecular recognition site; other site 760192011118 dimerization interface [polypeptide binding]; other site 760192011119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192011120 DNA binding site [nucleotide binding] 760192011121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192011122 dimer interface [polypeptide binding]; other site 760192011123 phosphorylation site [posttranslational modification] 760192011124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192011125 ATP binding site [chemical binding]; other site 760192011126 Mg2+ binding site [ion binding]; other site 760192011127 G-X-G motif; other site 760192011128 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 760192011129 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192011130 inhibitor-cofactor binding pocket; inhibition site 760192011131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192011132 catalytic residue [active] 760192011133 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 760192011134 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 760192011135 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192011136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192011137 S-adenosylmethionine binding site [chemical binding]; other site 760192011138 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 760192011139 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 760192011140 Walker A/P-loop; other site 760192011141 ATP binding site [chemical binding]; other site 760192011142 Q-loop/lid; other site 760192011143 ABC transporter signature motif; other site 760192011144 Walker B; other site 760192011145 D-loop; other site 760192011146 H-loop/switch region; other site 760192011147 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 760192011148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760192011149 dimer interface [polypeptide binding]; other site 760192011150 conserved gate region; other site 760192011151 putative PBP binding loops; other site 760192011152 ABC-ATPase subunit interface; other site 760192011153 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 760192011154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760192011155 dimer interface [polypeptide binding]; other site 760192011156 conserved gate region; other site 760192011157 putative PBP binding loops; other site 760192011158 ABC-ATPase subunit interface; other site 760192011159 PBP superfamily domain; Region: PBP_like_2; cl17296 760192011160 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192011161 active site 760192011162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 760192011163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192011164 TPR motif; other site 760192011165 binding surface 760192011166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192011167 binding surface 760192011168 TPR motif; other site 760192011169 Histidine kinase; Region: His_kinase; pfam06580 760192011170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 760192011171 putative anti-sigmaE protein; Provisional; Region: PRK13920 760192011172 Anti-sigma-K factor rskA; Region: RskA; pfam10099 760192011173 RNA polymerase sigma factor; Provisional; Region: PRK12519 760192011174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192011175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192011176 DNA binding residues [nucleotide binding] 760192011177 KWG Leptospira; Region: KWG; pfam07656 760192011178 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 760192011179 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 760192011180 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 760192011181 CAAX protease self-immunity; Region: Abi; pfam02517 760192011182 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 760192011183 active site 760192011184 hydrophilic channel; other site 760192011185 dimerization interface [polypeptide binding]; other site 760192011186 catalytic residues [active] 760192011187 active site lid [active] 760192011188 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192011189 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192011190 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192011191 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192011192 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 760192011193 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192011194 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 760192011195 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 760192011196 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192011197 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192011198 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192011199 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192011200 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192011201 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192011202 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192011203 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192011204 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760192011205 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 760192011206 active site 760192011207 DNA binding site [nucleotide binding] 760192011208 Int/Topo IB signature motif; other site 760192011209 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 760192011210 30S subunit binding site; other site 760192011211 elongation factor Tu; Reviewed; Region: PRK12735 760192011212 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 760192011213 G1 box; other site 760192011214 GEF interaction site [polypeptide binding]; other site 760192011215 GTP/Mg2+ binding site [chemical binding]; other site 760192011216 Switch I region; other site 760192011217 G2 box; other site 760192011218 G3 box; other site 760192011219 Switch II region; other site 760192011220 G4 box; other site 760192011221 G5 box; other site 760192011222 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 760192011223 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 760192011224 Antibiotic Binding Site [chemical binding]; other site 760192011225 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 760192011226 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 760192011227 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 760192011228 putative homodimer interface [polypeptide binding]; other site 760192011229 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 760192011230 heterodimer interface [polypeptide binding]; other site 760192011231 homodimer interface [polypeptide binding]; other site 760192011232 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 760192011233 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 760192011234 23S rRNA interface [nucleotide binding]; other site 760192011235 L7/L12 interface [polypeptide binding]; other site 760192011236 putative thiostrepton binding site; other site 760192011237 L25 interface [polypeptide binding]; other site 760192011238 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 760192011239 mRNA/rRNA interface [nucleotide binding]; other site 760192011240 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 760192011241 23S rRNA interface [nucleotide binding]; other site 760192011242 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 760192011243 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 760192011244 core dimer interface [polypeptide binding]; other site 760192011245 peripheral dimer interface [polypeptide binding]; other site 760192011246 L10 interface [polypeptide binding]; other site 760192011247 L11 interface [polypeptide binding]; other site 760192011248 putative EF-Tu interaction site [polypeptide binding]; other site 760192011249 putative EF-G interaction site [polypeptide binding]; other site 760192011250 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 760192011251 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 760192011252 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 760192011253 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 760192011254 RPB11 interaction site [polypeptide binding]; other site 760192011255 RPB12 interaction site [polypeptide binding]; other site 760192011256 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 760192011257 RPB3 interaction site [polypeptide binding]; other site 760192011258 RPB1 interaction site [polypeptide binding]; other site 760192011259 RPB11 interaction site [polypeptide binding]; other site 760192011260 RPB10 interaction site [polypeptide binding]; other site 760192011261 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 760192011262 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 760192011263 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 760192011264 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 760192011265 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 760192011266 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 760192011267 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 760192011268 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 760192011269 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 760192011270 DNA binding site [nucleotide binding] 760192011271 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 760192011272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192011273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192011274 active site 760192011275 phosphorylation site [posttranslational modification] 760192011276 intermolecular recognition site; other site 760192011277 dimerization interface [polypeptide binding]; other site 760192011278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192011279 DNA binding residues [nucleotide binding] 760192011280 dimerization interface [polypeptide binding]; other site 760192011281 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 760192011282 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 760192011283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192011284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192011285 ATP binding site [chemical binding]; other site 760192011286 Mg2+ binding site [ion binding]; other site 760192011287 G-X-G motif; other site 760192011288 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 760192011289 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 760192011290 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 760192011291 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 760192011292 putative sugar binding sites [chemical binding]; other site 760192011293 Q-X-W motif; other site 760192011294 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192011295 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192011296 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192011297 AAA ATPase domain; Region: AAA_16; pfam13191 760192011298 AAA domain; Region: AAA_22; pfam13401 760192011299 CHAT domain; Region: CHAT; cl17868 760192011300 Response regulator receiver domain; Region: Response_reg; pfam00072 760192011301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192011302 active site 760192011303 phosphorylation site [posttranslational modification] 760192011304 intermolecular recognition site; other site 760192011305 dimerization interface [polypeptide binding]; other site 760192011306 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192011307 DNA binding residues [nucleotide binding] 760192011308 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 760192011309 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 760192011310 NMT1-like family; Region: NMT1_2; pfam13379 760192011311 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 760192011312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760192011313 dimer interface [polypeptide binding]; other site 760192011314 conserved gate region; other site 760192011315 putative PBP binding loops; other site 760192011316 ABC-ATPase subunit interface; other site 760192011317 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 760192011318 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 760192011319 Walker A/P-loop; other site 760192011320 ATP binding site [chemical binding]; other site 760192011321 Q-loop/lid; other site 760192011322 ABC transporter signature motif; other site 760192011323 Walker B; other site 760192011324 D-loop; other site 760192011325 H-loop/switch region; other site 760192011326 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 760192011327 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 760192011328 Walker A/P-loop; other site 760192011329 ATP binding site [chemical binding]; other site 760192011330 Q-loop/lid; other site 760192011331 ABC transporter signature motif; other site 760192011332 Walker B; other site 760192011333 D-loop; other site 760192011334 H-loop/switch region; other site 760192011335 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 760192011336 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 760192011337 [4Fe-4S] binding site [ion binding]; other site 760192011338 molybdopterin cofactor binding site; other site 760192011339 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 760192011340 molybdopterin cofactor binding site; other site 760192011341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 760192011342 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 760192011343 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 760192011344 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 760192011345 Rubredoxin; Region: Rubredoxin; pfam00301 760192011346 iron binding site [ion binding]; other site 760192011347 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 760192011348 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 760192011349 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 760192011350 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 760192011351 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011352 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 760192011353 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 760192011354 active site 760192011355 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192011356 flagellar motor protein MotA; Validated; Region: PRK08124 760192011357 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011358 Tetratricopeptide repeat; Region: TPR_10; pfam13374 760192011359 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011360 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192011362 binding surface 760192011363 TPR motif; other site 760192011364 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011365 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011366 CHAT domain; Region: CHAT; pfam12770 760192011367 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192011368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192011369 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192011370 PGAP1-like protein; Region: PGAP1; pfam07819 760192011371 Transposase IS200 like; Region: Y1_Tnp; pfam01797 760192011372 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 760192011373 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 760192011374 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192011375 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 760192011376 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 760192011377 active site 760192011378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192011379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192011380 putative substrate translocation pore; other site 760192011381 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192011382 Cytokine receptor motif; other site 760192011383 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192011384 Interdomain contacts; other site 760192011385 Cytokine receptor motif; other site 760192011386 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011387 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 760192011388 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192011389 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192011390 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192011391 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192011392 SusD family; Region: SusD; pfam07980 760192011393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192011394 TPR motif; other site 760192011395 binding surface 760192011396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 760192011398 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192011399 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192011400 Asp-box motif; other site 760192011401 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 760192011402 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 760192011403 acyl-activating enzyme (AAE) consensus motif; other site 760192011404 putative AMP binding site [chemical binding]; other site 760192011405 putative active site [active] 760192011406 putative CoA binding site [chemical binding]; other site 760192011407 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 760192011408 beta-galactosidase; Region: BGL; TIGR03356 760192011409 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 760192011410 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 760192011411 Na binding site [ion binding]; other site 760192011412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 760192011413 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 760192011414 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 760192011415 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 760192011416 active site 760192011417 (T/H)XGH motif; other site 760192011418 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 760192011419 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 760192011420 Glutamate binding site [chemical binding]; other site 760192011421 NAD binding site [chemical binding]; other site 760192011422 catalytic residues [active] 760192011423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760192011424 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760192011425 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 760192011426 PGAP1-like protein; Region: PGAP1; pfam07819 760192011427 Methyltransferase domain; Region: Methyltransf_23; pfam13489 760192011428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192011429 S-adenosylmethionine binding site [chemical binding]; other site 760192011430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 760192011431 peptidase T; Region: peptidase-T; TIGR01882 760192011432 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 760192011433 metal binding site [ion binding]; metal-binding site 760192011434 dimer interface [polypeptide binding]; other site 760192011435 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011436 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 760192011437 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 760192011438 proposed catalytic triad [active] 760192011439 active site nucleophile [active] 760192011440 Transposase; Region: DEDD_Tnp_IS110; pfam01548 760192011441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 760192011442 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 760192011443 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 760192011444 proposed catalytic triad [active] 760192011445 active site nucleophile [active] 760192011446 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192011447 active site residue [active] 760192011448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192011449 Walker A/P-loop; other site 760192011450 ATP binding site [chemical binding]; other site 760192011451 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 760192011452 putative active site [active] 760192011453 putative metal-binding site [ion binding]; other site 760192011454 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 760192011455 Part of AAA domain; Region: AAA_19; pfam13245 760192011456 Family description; Region: UvrD_C_2; pfam13538 760192011457 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192011458 FtsX-like permease family; Region: FtsX; pfam02687 760192011459 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192011460 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192011461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192011462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192011463 putative substrate translocation pore; other site 760192011464 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192011465 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192011466 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192011467 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192011468 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192011469 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192011470 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192011471 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 760192011472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192011473 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 760192011474 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 760192011475 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 760192011476 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192011477 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192011478 Caspase domain; Region: Peptidase_C14; pfam00656 760192011479 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192011480 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192011481 Caspase domain; Region: Peptidase_C14; pfam00656 760192011482 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192011483 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192011484 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 760192011485 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192011486 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192011487 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 760192011488 nucleoside/Zn binding site; other site 760192011489 dimer interface [polypeptide binding]; other site 760192011490 catalytic motif [active] 760192011491 Uncharacterized conserved protein [Function unknown]; Region: COG4278 760192011492 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 760192011493 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192011494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192011495 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192011496 active site 760192011497 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192011498 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192011499 ligand binding site [chemical binding]; other site 760192011500 flexible hinge region; other site 760192011501 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760192011502 putative switch regulator; other site 760192011503 non-specific DNA interactions [nucleotide binding]; other site 760192011504 DNA binding site [nucleotide binding] 760192011505 sequence specific DNA binding site [nucleotide binding]; other site 760192011506 putative cAMP binding site [chemical binding]; other site 760192011507 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 760192011508 SWIM zinc finger; Region: SWIM; pfam04434 760192011509 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 760192011510 putative active site [active] 760192011511 Zn binding site [ion binding]; other site 760192011512 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 760192011513 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 760192011514 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192011515 active site 760192011516 Cupin domain; Region: Cupin_2; cl17218 760192011517 Caspase domain; Region: Peptidase_C14; pfam00656 760192011518 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 760192011519 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 760192011520 motif 1; other site 760192011521 active site 760192011522 motif 2; other site 760192011523 motif 3; other site 760192011524 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 760192011525 DHHA1 domain; Region: DHHA1; pfam02272 760192011526 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 760192011527 Peptidase family M23; Region: Peptidase_M23; pfam01551 760192011528 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192011529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192011530 active site 760192011531 phosphorylation site [posttranslational modification] 760192011532 intermolecular recognition site; other site 760192011533 dimerization interface [polypeptide binding]; other site 760192011534 LytTr DNA-binding domain; Region: LytTR; smart00850 760192011535 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 760192011536 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192011538 binding surface 760192011539 TPR motif; other site 760192011540 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011541 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192011543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192011544 dimer interface [polypeptide binding]; other site 760192011545 phosphorylation site [posttranslational modification] 760192011546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192011547 binding surface 760192011548 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192011549 TPR motif; other site 760192011550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192011551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192011552 dimer interface [polypeptide binding]; other site 760192011553 phosphorylation site [posttranslational modification] 760192011554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192011555 ATP binding site [chemical binding]; other site 760192011556 Mg2+ binding site [ion binding]; other site 760192011557 G-X-G motif; other site 760192011558 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 760192011559 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 760192011560 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 760192011561 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 760192011562 GatB domain; Region: GatB_Yqey; smart00845 760192011563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192011564 Walker A/P-loop; other site 760192011565 ATP binding site [chemical binding]; other site 760192011566 ABC transporter; Region: ABC_tran; pfam00005 760192011567 Q-loop/lid; other site 760192011568 ABC transporter signature motif; other site 760192011569 Walker B; other site 760192011570 D-loop; other site 760192011571 H-loop/switch region; other site 760192011572 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 760192011573 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 760192011574 active site 760192011575 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 760192011576 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 760192011577 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 760192011578 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 760192011579 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 760192011580 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 760192011581 trimer interface [polypeptide binding]; other site 760192011582 active site 760192011583 UDP-GlcNAc binding site [chemical binding]; other site 760192011584 lipid binding site [chemical binding]; lipid-binding site 760192011585 Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181 760192011586 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 760192011587 domain interfaces; other site 760192011588 active site 760192011589 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 760192011590 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 760192011591 active site 760192011592 Domain of unknown function (DUF4348); Region: DUF4348; pfam14254 760192011593 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 760192011594 active site 760192011595 catalytic residues [active] 760192011596 Calx-beta domain; Region: Calx-beta; cl02522 760192011597 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192011598 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192011599 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011600 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192011601 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192011602 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192011603 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 760192011604 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 760192011605 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192011606 active site 760192011607 metal binding site [ion binding]; metal-binding site 760192011608 hexamer interface [polypeptide binding]; other site 760192011609 Peptidase family C69; Region: Peptidase_C69; cl17793 760192011610 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 760192011611 active site 760192011612 catalytic residues [active] 760192011613 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192011614 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011615 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 760192011616 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 760192011617 hydrophobic ligand binding site; other site 760192011618 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 760192011619 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 760192011620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192011621 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 760192011622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192011623 DNA binding residues [nucleotide binding] 760192011624 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 760192011625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192011626 putative DNA binding site [nucleotide binding]; other site 760192011627 putative Zn2+ binding site [ion binding]; other site 760192011628 AsnC family; Region: AsnC_trans_reg; pfam01037 760192011629 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192011630 putative active site [active] 760192011631 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760192011632 C-terminal peptidase (prc); Region: prc; TIGR00225 760192011633 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760192011634 protein binding site [polypeptide binding]; other site 760192011635 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 760192011636 Catalytic dyad [active] 760192011637 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 760192011638 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192011639 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192011640 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192011641 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192011642 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192011643 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192011644 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192011645 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192011646 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192011647 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 760192011648 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 760192011649 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 760192011650 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 760192011651 active site 760192011652 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 760192011653 active site 760192011654 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 760192011655 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192011656 active site 760192011657 Caspase domain; Region: Peptidase_C14; pfam00656 760192011658 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192011659 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192011660 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192011661 putative active site [active] 760192011662 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 760192011663 S17 interaction site [polypeptide binding]; other site 760192011664 S8 interaction site; other site 760192011665 16S rRNA interaction site [nucleotide binding]; other site 760192011666 streptomycin interaction site [chemical binding]; other site 760192011667 23S rRNA interaction site [nucleotide binding]; other site 760192011668 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 760192011669 30S ribosomal protein S7; Validated; Region: PRK05302 760192011670 elongation factor G; Reviewed; Region: PRK12739 760192011671 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 760192011672 G1 box; other site 760192011673 putative GEF interaction site [polypeptide binding]; other site 760192011674 GTP/Mg2+ binding site [chemical binding]; other site 760192011675 Switch I region; other site 760192011676 G2 box; other site 760192011677 G3 box; other site 760192011678 Switch II region; other site 760192011679 G4 box; other site 760192011680 G5 box; other site 760192011681 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 760192011682 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 760192011683 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 760192011684 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 760192011685 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 760192011686 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 760192011687 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 760192011688 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 760192011689 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 760192011690 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 760192011691 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 760192011692 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 760192011693 putative translocon binding site; other site 760192011694 protein-rRNA interface [nucleotide binding]; other site 760192011695 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 760192011696 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 760192011697 G-X-X-G motif; other site 760192011698 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 760192011699 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 760192011700 23S rRNA interface [nucleotide binding]; other site 760192011701 5S rRNA interface [nucleotide binding]; other site 760192011702 putative antibiotic binding site [chemical binding]; other site 760192011703 L25 interface [polypeptide binding]; other site 760192011704 L27 interface [polypeptide binding]; other site 760192011705 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 760192011706 putative translocon interaction site; other site 760192011707 23S rRNA interface [nucleotide binding]; other site 760192011708 signal recognition particle (SRP54) interaction site; other site 760192011709 L23 interface [polypeptide binding]; other site 760192011710 trigger factor interaction site; other site 760192011711 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 760192011712 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 760192011713 ribosomal protein L24, bacterial/organelle; Region: rplX_bact; TIGR01079 760192011714 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 760192011715 RNA binding site [nucleotide binding]; other site 760192011716 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 760192011717 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 760192011718 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 760192011719 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 760192011720 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 760192011721 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 760192011722 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 760192011723 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 760192011724 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 760192011725 5S rRNA interface [nucleotide binding]; other site 760192011726 L27 interface [polypeptide binding]; other site 760192011727 23S rRNA interface [nucleotide binding]; other site 760192011728 L5 interface [polypeptide binding]; other site 760192011729 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 760192011730 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 760192011731 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 760192011732 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 760192011733 23S rRNA binding site [nucleotide binding]; other site 760192011734 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 760192011735 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 760192011736 SecY translocase; Region: SecY; pfam00344 760192011737 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 760192011738 active site 760192011739 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 760192011740 rRNA binding site [nucleotide binding]; other site 760192011741 predicted 30S ribosome binding site; other site 760192011742 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 760192011743 30S ribosomal protein S13; Region: bact_S13; TIGR03631 760192011744 30S ribosomal protein S11; Validated; Region: PRK05309 760192011745 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 760192011746 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 760192011747 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760192011748 RNA binding surface [nucleotide binding]; other site 760192011749 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 760192011750 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 760192011751 alphaNTD - beta interaction site [polypeptide binding]; other site 760192011752 alphaNTD homodimer interface [polypeptide binding]; other site 760192011753 alphaNTD - beta' interaction site [polypeptide binding]; other site 760192011754 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 760192011755 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 760192011756 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 760192011757 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 760192011758 XisI protein; Region: XisI; pfam08869 760192011759 XisH protein; Region: XisH; pfam08814 760192011760 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011761 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 760192011762 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 760192011763 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 760192011764 catalytic site [active] 760192011765 subunit interface [polypeptide binding]; other site 760192011766 enolase; Provisional; Region: eno; PRK00077 760192011767 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 760192011768 dimer interface [polypeptide binding]; other site 760192011769 metal binding site [ion binding]; metal-binding site 760192011770 substrate binding pocket [chemical binding]; other site 760192011771 Septum formation initiator; Region: DivIC; cl17659 760192011772 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 760192011773 CoA binding domain; Region: CoA_binding; smart00881 760192011774 CoA-ligase; Region: Ligase_CoA; pfam00549 760192011775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192011776 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192011777 putative substrate translocation pore; other site 760192011778 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 760192011779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760192011780 active site 760192011781 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 760192011782 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 760192011783 putative trimer interface [polypeptide binding]; other site 760192011784 putative CoA binding site [chemical binding]; other site 760192011785 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 760192011786 iron-sulfur cluster [ion binding]; other site 760192011787 [2Fe-2S] cluster binding site [ion binding]; other site 760192011788 Amidohydrolase; Region: Amidohydro_2; pfam04909 760192011789 beta-carotene hydroxylase; Region: PLN02601 760192011790 Protein of unknown function (DUF422); Region: DUF422; cl00991 760192011791 phytoene desaturase; Region: crtI_fam; TIGR02734 760192011792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192011793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192011794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760192011795 dimerization interface [polypeptide binding]; other site 760192011796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192011797 dimer interface [polypeptide binding]; other site 760192011798 phosphorylation site [posttranslational modification] 760192011799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192011800 ATP binding site [chemical binding]; other site 760192011801 Mg2+ binding site [ion binding]; other site 760192011802 G-X-G motif; other site 760192011803 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 760192011804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192011805 non-specific DNA binding site [nucleotide binding]; other site 760192011806 salt bridge; other site 760192011807 sequence-specific DNA binding site [nucleotide binding]; other site 760192011808 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011809 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 760192011810 active site 760192011811 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 760192011812 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 760192011813 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 760192011814 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 760192011815 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 760192011816 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 760192011817 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760192011818 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760192011819 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 760192011820 active site 760192011821 metal binding site [ion binding]; metal-binding site 760192011822 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192011823 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192011824 ligand binding site [chemical binding]; other site 760192011825 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192011826 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192011827 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192011828 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192011829 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192011830 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192011831 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192011832 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192011833 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192011834 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192011835 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192011836 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 760192011837 dimerization interface [polypeptide binding]; other site 760192011838 active site 760192011839 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 760192011840 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 760192011841 NAD(P) binding site [chemical binding]; other site 760192011842 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192011843 putative active site [active] 760192011844 Uncharacterized conserved protein [Function unknown]; Region: COG4850 760192011845 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 760192011846 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 760192011847 Sporulation related domain; Region: SPOR; pfam05036 760192011848 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 760192011849 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 760192011850 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 760192011851 GTP binding site [chemical binding]; other site 760192011852 ribosomal protein L33; Region: rpl33; CHL00104 760192011853 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 760192011854 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 760192011855 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192011856 dockerin binding interface; other site 760192011857 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011858 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 760192011859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192011860 DNA binding residues [nucleotide binding] 760192011861 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 760192011862 FecR protein; Region: FecR; pfam04773 760192011863 Secretin and TonB N terminus short domain; Region: STN; pfam07660 760192011864 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192011865 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192011866 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192011867 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192011868 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192011869 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192011870 Family description; Region: VCBS; pfam13517 760192011871 Family description; Region: VCBS; pfam13517 760192011872 Family description; Region: VCBS; pfam13517 760192011873 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 760192011874 Family description; Region: VCBS; pfam13517 760192011875 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 760192011876 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 760192011877 catalytic triad [active] 760192011878 putative active site [active] 760192011879 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011880 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192011881 Leucine-rich repeats, typical (most populated) subfamily; Region: LRR_TYP; cl15310 760192011882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192011883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192011884 active site 760192011885 phosphorylation site [posttranslational modification] 760192011886 dimerization interface [polypeptide binding]; other site 760192011887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192011888 DNA binding residues [nucleotide binding] 760192011889 dimerization interface [polypeptide binding]; other site 760192011890 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 760192011891 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 760192011892 dihydropteroate synthase; Region: DHPS; TIGR01496 760192011893 substrate binding pocket [chemical binding]; other site 760192011894 dimer interface [polypeptide binding]; other site 760192011895 inhibitor binding site; inhibition site 760192011896 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 760192011897 Family description; Region: VCBS; pfam13517 760192011898 Family description; Region: VCBS; pfam13517 760192011899 FG-GAP repeat; Region: FG-GAP; pfam01839 760192011900 Family description; Region: VCBS; pfam13517 760192011901 Family description; Region: VCBS; pfam13517 760192011902 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 760192011903 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 760192011904 active site 760192011905 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 760192011906 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 760192011907 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 760192011908 active site 760192011909 RNA/DNA hybrid binding site [nucleotide binding]; other site 760192011910 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 760192011911 active site 760192011912 catalytic residues [active] 760192011913 metal binding site [ion binding]; metal-binding site 760192011914 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 760192011915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192011916 S-adenosylmethionine binding site [chemical binding]; other site 760192011917 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 760192011918 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 760192011919 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 760192011920 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192011921 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192011922 catalytic residues [active] 760192011923 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 760192011924 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192011925 putative catalytic residue [active] 760192011926 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 760192011927 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760192011928 RNA binding surface [nucleotide binding]; other site 760192011929 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 760192011930 probable active site [active] 760192011931 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192011932 Asp-box motif; other site 760192011933 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 760192011934 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192011935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192011936 active site 760192011937 phosphorylation site [posttranslational modification] 760192011938 intermolecular recognition site; other site 760192011939 dimerization interface [polypeptide binding]; other site 760192011940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192011941 DNA binding residues [nucleotide binding] 760192011942 dimerization interface [polypeptide binding]; other site 760192011943 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760192011944 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192011945 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 760192011946 Walker A/P-loop; other site 760192011947 ATP binding site [chemical binding]; other site 760192011948 Q-loop/lid; other site 760192011949 ABC transporter signature motif; other site 760192011950 Walker B; other site 760192011951 D-loop; other site 760192011952 H-loop/switch region; other site 760192011953 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 760192011954 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192011955 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192011956 DNA binding residues [nucleotide binding] 760192011957 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760192011958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760192011959 DNA binding site [nucleotide binding] 760192011960 domain linker motif; other site 760192011961 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760192011962 dimerization interface [polypeptide binding]; other site 760192011963 ligand binding site [chemical binding]; other site 760192011964 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 760192011965 four helix bundle protein; Region: TIGR02436 760192011966 glutamine synthetase; Region: PLN02284 760192011967 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 760192011968 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 760192011969 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 760192011970 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 760192011971 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 760192011972 active site 760192011973 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 760192011974 Amidinotransferase; Region: Amidinotransf; pfam02274 760192011975 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192011976 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192011977 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192011978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192011979 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192011980 dockerin binding interface; other site 760192011981 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011982 Putative Ig domain; Region: He_PIG; pfam05345 760192011983 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192011984 dockerin binding interface; other site 760192011985 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192011986 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192011987 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011988 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011989 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011990 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011991 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011992 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011993 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011994 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011995 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011996 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 760192011997 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192011998 dockerin binding interface; other site 760192011999 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192012001 Histidine kinase; Region: HisKA_2; pfam07568 760192012002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192012003 Mg2+ binding site [ion binding]; other site 760192012004 G-X-G motif; other site 760192012005 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192012006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012007 active site 760192012008 phosphorylation site [posttranslational modification] 760192012009 intermolecular recognition site; other site 760192012010 dimerization interface [polypeptide binding]; other site 760192012011 LytTr DNA-binding domain; Region: LytTR; smart00850 760192012012 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 760192012013 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 760192012014 Histidine kinase; Region: His_kinase; pfam06580 760192012015 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 760192012016 thymidylate synthase; Reviewed; Region: thyA; PRK01827 760192012017 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 760192012018 dimerization interface [polypeptide binding]; other site 760192012019 active site 760192012020 Cytochrome c; Region: Cytochrom_C; pfam00034 760192012021 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 760192012022 heme-binding residues [chemical binding]; other site 760192012023 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 760192012024 heme-binding residues [chemical binding]; other site 760192012025 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 760192012026 molybdopterin cofactor binding site; other site 760192012027 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 760192012028 4Fe-4S binding domain; Region: Fer4_2; pfam12797 760192012029 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 760192012030 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 760192012031 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 760192012032 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 760192012033 Cytochrome c; Region: Cytochrom_C; pfam00034 760192012034 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 760192012035 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 760192012036 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 760192012037 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192012038 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192012039 ligand binding site [chemical binding]; other site 760192012040 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 760192012041 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 760192012042 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 760192012043 UbiA prenyltransferase family; Region: UbiA; pfam01040 760192012044 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 760192012045 Subunit I/III interface [polypeptide binding]; other site 760192012046 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 760192012047 Subunit I/III interface [polypeptide binding]; other site 760192012048 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 760192012049 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 760192012050 Protein of unknown function (DUF420); Region: DUF420; pfam04238 760192012051 Protein of unknown function (DUF423); Region: DUF423; pfam04241 760192012052 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192012053 Two component regulator propeller; Region: Reg_prop; pfam07494 760192012054 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192012055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192012056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192012057 dimer interface [polypeptide binding]; other site 760192012058 phosphorylation site [posttranslational modification] 760192012059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192012060 ATP binding site [chemical binding]; other site 760192012061 Mg2+ binding site [ion binding]; other site 760192012062 G-X-G motif; other site 760192012063 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192012064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012065 active site 760192012066 phosphorylation site [posttranslational modification] 760192012067 intermolecular recognition site; other site 760192012068 dimerization interface [polypeptide binding]; other site 760192012069 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192012070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192012071 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 760192012072 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 760192012073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192012074 ATP binding site [chemical binding]; other site 760192012075 putative Mg++ binding site [ion binding]; other site 760192012076 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 760192012077 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760192012078 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760192012079 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 760192012080 HsdM N-terminal domain; Region: HsdM_N; pfam12161 760192012081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192012082 S-adenosylmethionine binding site [chemical binding]; other site 760192012083 Transposase IS200 like; Region: Y1_Tnp; pfam01797 760192012084 KilA-N domain; Region: KilA-N; pfam04383 760192012085 DoxX-like family; Region: DoxX_2; pfam13564 760192012086 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760192012087 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760192012088 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760192012089 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 760192012090 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 760192012091 SusE outer membrane protein; Region: SusE; pfam14292 760192012092 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 760192012093 starch binding site [chemical binding]; other site 760192012094 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 760192012095 starch binding site [chemical binding]; other site 760192012096 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192012097 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192012098 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192012099 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192012100 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192012101 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192012102 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192012103 Pirin; Region: Pirin; pfam02678 760192012104 Pirin-related protein [General function prediction only]; Region: COG1741 760192012105 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 760192012106 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 760192012107 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 760192012108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012109 active site 760192012110 phosphorylation site [posttranslational modification] 760192012111 intermolecular recognition site; other site 760192012112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192012113 Walker A motif; other site 760192012114 ATP binding site [chemical binding]; other site 760192012115 Walker B motif; other site 760192012116 arginine finger; other site 760192012117 TIR domain; Region: TIR_2; pfam13676 760192012118 Sporulation related domain; Region: SPOR; pfam05036 760192012119 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 760192012120 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 760192012121 TraB family; Region: TraB; pfam01963 760192012122 Winged helix-turn helix; Region: HTH_29; pfam13551 760192012123 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192012124 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 760192012125 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192012126 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 760192012127 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 760192012128 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192012129 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192012130 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192012131 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192012132 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 760192012133 Leucine-rich repeats; other site 760192012134 Substrate binding site [chemical binding]; other site 760192012135 Leucine rich repeat; Region: LRR_8; pfam13855 760192012136 Leucine rich repeat; Region: LRR_8; pfam13855 760192012137 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192012138 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 760192012139 G1 box; other site 760192012140 GTP/Mg2+ binding site [chemical binding]; other site 760192012141 G2 box; other site 760192012142 Switch I region; other site 760192012143 G3 box; other site 760192012144 Switch II region; other site 760192012145 G4 box; other site 760192012146 G5 box; other site 760192012147 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 760192012148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192012149 NAD(P) binding site [chemical binding]; other site 760192012150 active site 760192012151 Domain of unknown function (DUF362); Region: DUF362; pfam04015 760192012152 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 760192012153 active site 760192012154 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192012155 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 760192012156 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760192012157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192012158 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 760192012159 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 760192012160 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 760192012161 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 760192012162 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192012163 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 760192012164 active site 760192012165 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192012166 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192012167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192012168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192012169 dimer interface [polypeptide binding]; other site 760192012170 phosphorylation site [posttranslational modification] 760192012171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192012172 ATP binding site [chemical binding]; other site 760192012173 Mg2+ binding site [ion binding]; other site 760192012174 G-X-G motif; other site 760192012175 Response regulator receiver domain; Region: Response_reg; pfam00072 760192012176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012177 active site 760192012178 phosphorylation site [posttranslational modification] 760192012179 intermolecular recognition site; other site 760192012180 dimerization interface [polypeptide binding]; other site 760192012181 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760192012182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192012183 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192012184 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760192012185 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192012186 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192012187 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 760192012188 DoxX; Region: DoxX; pfam07681 760192012189 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 760192012190 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 760192012191 Predicted membrane protein [Function unknown]; Region: COG2860 760192012192 UPF0126 domain; Region: UPF0126; pfam03458 760192012193 UPF0126 domain; Region: UPF0126; pfam03458 760192012194 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 760192012195 L-fuculokinase; Region: fuculo_kin_coli; TIGR02628 760192012196 nucleotide binding site [chemical binding]; other site 760192012197 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 760192012198 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 760192012199 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 760192012200 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 760192012201 PIN domain; Region: PIN_3; pfam13470 760192012202 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 760192012203 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192012204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012205 active site 760192012206 phosphorylation site [posttranslational modification] 760192012207 intermolecular recognition site; other site 760192012208 dimerization interface [polypeptide binding]; other site 760192012209 LytTr DNA-binding domain; Region: LytTR; smart00850 760192012210 Histidine kinase; Region: His_kinase; pfam06580 760192012211 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 760192012212 ABC1 family; Region: ABC1; pfam03109 760192012213 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 760192012214 active site 760192012215 ATP binding site [chemical binding]; other site 760192012216 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 760192012217 Acyltransferase family; Region: Acyl_transf_3; pfam01757 760192012218 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192012219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192012220 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192012221 Putative esterase; Region: Esterase; pfam00756 760192012222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 760192012223 TIR domain; Region: TIR_2; pfam13676 760192012224 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192012225 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192012226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012227 binding surface 760192012228 TPR repeat; Region: TPR_11; pfam13414 760192012229 TPR motif; other site 760192012230 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 760192012231 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192012232 putative active site [active] 760192012233 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192012234 Sulfatase; Region: Sulfatase; pfam00884 760192012235 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 760192012236 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 760192012237 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192012238 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192012239 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 760192012240 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192012241 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192012242 ligand binding site [chemical binding]; other site 760192012243 flexible hinge region; other site 760192012244 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 760192012245 Zn binding site [ion binding]; other site 760192012246 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 760192012247 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 760192012248 TrkA-C domain; Region: TrkA_C; pfam02080 760192012249 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 760192012250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192012251 S-adenosylmethionine binding site [chemical binding]; other site 760192012252 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 760192012253 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 760192012254 substrate binding site [chemical binding]; other site 760192012255 active site 760192012256 catalytic residues [active] 760192012257 heterodimer interface [polypeptide binding]; other site 760192012258 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 760192012259 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 760192012260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192012261 catalytic residue [active] 760192012262 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 760192012263 active site 760192012264 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 760192012265 active site 760192012266 ribulose/triose binding site [chemical binding]; other site 760192012267 phosphate binding site [ion binding]; other site 760192012268 substrate (anthranilate) binding pocket [chemical binding]; other site 760192012269 product (indole) binding pocket [chemical binding]; other site 760192012270 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 760192012271 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 760192012272 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 760192012273 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 760192012274 Glutamine amidotransferase class-I; Region: GATase; pfam00117 760192012275 glutamine binding [chemical binding]; other site 760192012276 catalytic triad [active] 760192012277 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 760192012278 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 760192012279 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 760192012280 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192012281 Protein of unknown function, DUF486; Region: DUF486; cl01236 760192012282 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 760192012283 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 760192012284 tetramer interface [polypeptide binding]; other site 760192012285 active site 760192012286 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 760192012287 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 760192012288 dimer interface [polypeptide binding]; other site 760192012289 active site 760192012290 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 760192012291 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 760192012292 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 760192012293 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 760192012294 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 760192012295 active site 760192012296 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 760192012297 heterodimer interface [polypeptide binding]; other site 760192012298 multimer interface [polypeptide binding]; other site 760192012299 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 760192012300 active site 760192012301 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 760192012302 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 760192012303 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 760192012304 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 760192012305 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192012306 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192012307 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 760192012308 putative active site [active] 760192012309 YdjC motif; other site 760192012310 Mg binding site [ion binding]; other site 760192012311 homodimer interface [polypeptide binding]; other site 760192012312 Membrane transport protein; Region: Mem_trans; cl09117 760192012313 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 760192012314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760192012315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192012316 homodimer interface [polypeptide binding]; other site 760192012317 catalytic residue [active] 760192012318 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012320 binding surface 760192012321 TPR motif; other site 760192012322 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012324 binding surface 760192012325 TPR motif; other site 760192012326 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012328 binding surface 760192012329 TPR motif; other site 760192012330 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012331 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012333 binding surface 760192012334 TPR motif; other site 760192012335 CHAT domain; Region: CHAT; pfam12770 760192012336 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192012337 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192012338 putative active site [active] 760192012339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 760192012340 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 760192012341 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 760192012342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192012343 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192012344 Walker A motif; other site 760192012345 ATP binding site [chemical binding]; other site 760192012346 Walker B motif; other site 760192012347 PemK-like protein; Region: PemK; pfam02452 760192012348 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192012349 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192012350 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192012351 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192012352 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192012353 HYR domain; Region: HYR; pfam02494 760192012354 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192012355 Ceramidase; Region: Ceramidase; pfam05875 760192012356 Divergent AAA domain; Region: AAA_4; pfam04326 760192012357 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 760192012358 Putative addiction module component; Region: Unstab_antitox; cl09921 760192012359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012360 binding surface 760192012361 TPR motif; other site 760192012362 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012363 TPR repeat; Region: TPR_11; pfam13414 760192012364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012365 binding surface 760192012366 TPR motif; other site 760192012367 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012369 binding surface 760192012370 TPR motif; other site 760192012371 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012372 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012374 binding surface 760192012375 TPR motif; other site 760192012376 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012377 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012379 binding surface 760192012380 TPR motif; other site 760192012381 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012382 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012384 binding surface 760192012385 TPR motif; other site 760192012386 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012387 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012389 binding surface 760192012390 TPR motif; other site 760192012391 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012392 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 760192012393 four helix bundle protein; Region: TIGR02436 760192012394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192012395 non-specific DNA binding site [nucleotide binding]; other site 760192012396 salt bridge; other site 760192012397 sequence-specific DNA binding site [nucleotide binding]; other site 760192012398 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 760192012399 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 760192012400 Transcriptional regulators [Transcription]; Region: MarR; COG1846 760192012401 MarR family; Region: MarR_2; pfam12802 760192012402 TPR repeat; Region: TPR_11; pfam13414 760192012403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012404 binding surface 760192012405 TPR motif; other site 760192012406 TPR repeat; Region: TPR_11; pfam13414 760192012407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012408 binding surface 760192012409 TPR motif; other site 760192012410 TPR repeat; Region: TPR_11; pfam13414 760192012411 TPR repeat; Region: TPR_11; pfam13414 760192012412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012413 binding surface 760192012414 TPR motif; other site 760192012415 TPR repeat; Region: TPR_11; pfam13414 760192012416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192012417 binding surface 760192012418 TPR motif; other site 760192012419 Methyltransferase domain; Region: Methyltransf_31; pfam13847 760192012420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192012421 S-adenosylmethionine binding site [chemical binding]; other site 760192012422 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 760192012423 polyphosphate kinase; Provisional; Region: PRK05443 760192012424 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 760192012425 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 760192012426 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 760192012427 domain interface [polypeptide binding]; other site 760192012428 active site 760192012429 catalytic site [active] 760192012430 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 760192012431 domain interface [polypeptide binding]; other site 760192012432 active site 760192012433 catalytic site [active] 760192012434 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192012435 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 760192012436 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192012437 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 760192012438 Walker A/P-loop; other site 760192012439 ATP binding site [chemical binding]; other site 760192012440 Q-loop/lid; other site 760192012441 ABC transporter signature motif; other site 760192012442 Walker B; other site 760192012443 D-loop; other site 760192012444 H-loop/switch region; other site 760192012445 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 760192012446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192012447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192012448 YceI-like domain; Region: YceI; pfam04264 760192012449 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760192012450 MarR family; Region: MarR_2; pfam12802 760192012451 MarR family; Region: MarR_2; cl17246 760192012452 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 760192012453 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 760192012454 RmuC family; Region: RmuC; pfam02646 760192012455 Histidine kinase; Region: His_kinase; pfam06580 760192012456 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 760192012457 ZIP Zinc transporter; Region: Zip; pfam02535 760192012458 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 760192012459 Mechanosensitive ion channel; Region: MS_channel; pfam00924 760192012460 EVE domain; Region: EVE; pfam01878 760192012461 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 760192012462 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 760192012463 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192012464 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192012465 PspC domain; Region: PspC; cl00864 760192012466 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 760192012467 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 760192012468 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 760192012469 ferrochelatase; Reviewed; Region: hemH; PRK00035 760192012470 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 760192012471 C-terminal domain interface [polypeptide binding]; other site 760192012472 active site 760192012473 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 760192012474 active site 760192012475 N-terminal domain interface [polypeptide binding]; other site 760192012476 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192012477 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192012478 active site 760192012479 catalytic tetrad [active] 760192012480 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 760192012481 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192012482 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192012483 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192012484 CheB methylesterase; Region: CheB_methylest; pfam01339 760192012485 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 760192012486 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 760192012487 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 760192012488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192012489 PAS domain; Region: PAS_9; pfam13426 760192012490 putative active site [active] 760192012491 heme pocket [chemical binding]; other site 760192012492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192012493 dimer interface [polypeptide binding]; other site 760192012494 phosphorylation site [posttranslational modification] 760192012495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192012496 ATP binding site [chemical binding]; other site 760192012497 Mg2+ binding site [ion binding]; other site 760192012498 G-X-G motif; other site 760192012499 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192012500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012501 active site 760192012502 phosphorylation site [posttranslational modification] 760192012503 intermolecular recognition site; other site 760192012504 dimerization interface [polypeptide binding]; other site 760192012505 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 760192012506 NAD binding site [chemical binding]; other site 760192012507 NADH(P)-binding; Region: NAD_binding_10; pfam13460 760192012508 active site 760192012509 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192012510 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 760192012511 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 760192012512 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 760192012513 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 760192012514 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 760192012515 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 760192012516 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192012517 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192012518 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 760192012519 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 760192012520 putative active site [active] 760192012521 Zn binding site [ion binding]; other site 760192012522 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 760192012523 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192012524 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 760192012525 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 760192012526 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 760192012527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192012528 motif II; other site 760192012529 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192012530 Alpha-2-macroglobulin family; Region: A2M; pfam00207 760192012531 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 760192012532 surface patch; other site 760192012533 thioester region; other site 760192012534 specificity defining residues; other site 760192012535 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 760192012536 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 760192012537 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 760192012538 nucleotide binding site [chemical binding]; other site 760192012539 putative NEF/HSP70 interaction site [polypeptide binding]; other site 760192012540 SBD interface [polypeptide binding]; other site 760192012541 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 760192012542 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 760192012543 dimer interface [polypeptide binding]; other site 760192012544 active site 760192012545 heme binding site [chemical binding]; other site 760192012546 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 760192012547 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 760192012548 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192012549 FtsX-like permease family; Region: FtsX; pfam02687 760192012550 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192012551 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 760192012552 putative chaperone; Provisional; Region: PRK11678 760192012553 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 760192012554 nucleotide binding site [chemical binding]; other site 760192012555 putative NEF/HSP70 interaction site [polypeptide binding]; other site 760192012556 SBD interface [polypeptide binding]; other site 760192012557 DoxX; Region: DoxX; cl17842 760192012558 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 760192012559 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 760192012560 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192012561 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192012562 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192012563 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192012564 N-terminal plug; other site 760192012565 ligand-binding site [chemical binding]; other site 760192012566 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 760192012567 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 760192012568 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 760192012569 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 760192012570 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 760192012571 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760192012572 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760192012573 Walker A/P-loop; other site 760192012574 ATP binding site [chemical binding]; other site 760192012575 Q-loop/lid; other site 760192012576 ABC transporter signature motif; other site 760192012577 Walker B; other site 760192012578 D-loop; other site 760192012579 H-loop/switch region; other site 760192012580 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 760192012581 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192012582 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 760192012583 Response regulator receiver domain; Region: Response_reg; pfam00072 760192012584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012585 active site 760192012586 phosphorylation site [posttranslational modification] 760192012587 intermolecular recognition site; other site 760192012588 dimerization interface [polypeptide binding]; other site 760192012589 LytTr DNA-binding domain; Region: LytTR; smart00850 760192012590 Histidine kinase; Region: His_kinase; pfam06580 760192012591 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 760192012592 GLPGLI family protein; Region: GLPGLI; TIGR01200 760192012593 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192012594 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192012595 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192012596 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192012597 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 760192012598 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 760192012599 generic binding surface II; other site 760192012600 generic binding surface I; other site 760192012601 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 760192012602 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 760192012603 catalytic center binding site [active] 760192012604 ATP binding site [chemical binding]; other site 760192012605 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 760192012606 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 760192012607 Substrate-binding site [chemical binding]; other site 760192012608 Substrate specificity [chemical binding]; other site 760192012609 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 760192012610 FAD binding domain; Region: FAD_binding_4; pfam01565 760192012611 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 760192012612 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 760192012613 active site 760192012614 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192012615 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760192012616 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192012617 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192012618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760192012619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192012620 Protein of unknown function (DUF458); Region: DUF458; cl00861 760192012621 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 760192012622 putative active site pocket [active] 760192012623 dimerization interface [polypeptide binding]; other site 760192012624 putative catalytic residue [active] 760192012625 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 760192012626 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192012627 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192012628 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192012629 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192012630 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192012631 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192012632 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192012633 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 760192012634 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192012635 PA14 domain; Region: PA14; cl08459 760192012636 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 760192012637 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 760192012638 Nucleoside recognition; Region: Gate; pfam07670 760192012639 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 760192012640 YCII-related domain; Region: YCII; cl00999 760192012641 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192012642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012643 active site 760192012644 phosphorylation site [posttranslational modification] 760192012645 intermolecular recognition site; other site 760192012646 dimerization interface [polypeptide binding]; other site 760192012647 LytTr DNA-binding domain; Region: LytTR; smart00850 760192012648 Histidine kinase; Region: His_kinase; pfam06580 760192012649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 760192012650 ATP binding site [chemical binding]; other site 760192012651 Mg2+ binding site [ion binding]; other site 760192012652 G-X-G motif; other site 760192012653 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192012654 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 760192012655 substrate binding pocket [chemical binding]; other site 760192012656 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192012657 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192012658 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 760192012659 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 760192012660 substrate binding site [chemical binding]; other site 760192012661 oxyanion hole (OAH) forming residues; other site 760192012662 trimer interface [polypeptide binding]; other site 760192012663 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 760192012664 30S subunit binding site; other site 760192012665 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 760192012666 L-fucose transporter; Provisional; Region: PRK10133; cl17665 760192012667 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 760192012668 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192012669 active site 760192012670 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192012671 catalytic tetrad [active] 760192012672 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 760192012673 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760192012674 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760192012675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192012676 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192012677 putative active site [active] 760192012678 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 760192012679 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192012680 catalytic loop [active] 760192012681 iron binding site [ion binding]; other site 760192012682 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 760192012683 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 760192012684 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 760192012685 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192012686 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192012687 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 760192012688 23S rRNA binding site [nucleotide binding]; other site 760192012689 L21 binding site [polypeptide binding]; other site 760192012690 L13 binding site [polypeptide binding]; other site 760192012691 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 760192012692 Bacterial Ig-like domain; Region: Big_5; pfam13205 760192012693 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 760192012694 generic binding surface I; other site 760192012695 generic binding surface II; other site 760192012696 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 760192012697 putative active site [active] 760192012698 putative catalytic site [active] 760192012699 putative Mg binding site IVb [ion binding]; other site 760192012700 putative DNA binding site [nucleotide binding]; other site 760192012701 putative phosphate binding site [ion binding]; other site 760192012702 putative Mg binding site IVa [ion binding]; other site 760192012703 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192012704 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192012705 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 760192012706 putative catalytic site [active] 760192012707 putative metal binding site [ion binding]; other site 760192012708 putative phosphate binding site [ion binding]; other site 760192012709 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192012710 dockerin binding interface; other site 760192012711 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192012712 dockerin binding interface; other site 760192012713 peptidase T; Region: peptidase-T; TIGR01882 760192012714 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 760192012715 metal binding site [ion binding]; metal-binding site 760192012716 dimer interface [polypeptide binding]; other site 760192012717 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760192012718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192012719 Coenzyme A binding pocket [chemical binding]; other site 760192012720 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 760192012721 Phage Tail Collar Domain; Region: Collar; pfam07484 760192012722 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 760192012723 Phage Tail Collar Domain; Region: Collar; pfam07484 760192012724 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 760192012725 Phage Tail Collar Domain; Region: Collar; pfam07484 760192012726 Calx-beta domain; Region: Calx-beta; cl02522 760192012727 Calx-beta domain; Region: Calx-beta; cl02522 760192012728 Calx-beta domain; Region: Calx-beta; cl02522 760192012729 flagellin; Validated; Region: PRK08026 760192012730 Calx-beta domain; Region: Calx-beta; cl02522 760192012731 Calx-beta domain; Region: Calx-beta; cl02522 760192012732 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192012733 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192012734 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 760192012735 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 760192012736 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 760192012737 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 760192012738 Clp amino terminal domain; Region: Clp_N; pfam02861 760192012739 Clp amino terminal domain; Region: Clp_N; pfam02861 760192012740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192012741 Walker A motif; other site 760192012742 ATP binding site [chemical binding]; other site 760192012743 Walker B motif; other site 760192012744 arginine finger; other site 760192012745 UvrB/uvrC motif; Region: UVR; pfam02151 760192012746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192012747 Walker A motif; other site 760192012748 ATP binding site [chemical binding]; other site 760192012749 Walker B motif; other site 760192012750 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 760192012751 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 760192012752 anti sigma factor interaction site; other site 760192012753 regulatory phosphorylation site [posttranslational modification]; other site 760192012754 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192012755 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192012756 ligand binding site [chemical binding]; other site 760192012757 flexible hinge region; other site 760192012758 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760192012759 putative switch regulator; other site 760192012760 non-specific DNA interactions [nucleotide binding]; other site 760192012761 DNA binding site [nucleotide binding] 760192012762 sequence specific DNA binding site [nucleotide binding]; other site 760192012763 putative cAMP binding site [chemical binding]; other site 760192012764 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192012765 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192012766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192012767 PAS domain; Region: PAS_9; pfam13426 760192012768 putative active site [active] 760192012769 heme pocket [chemical binding]; other site 760192012770 PAS domain S-box; Region: sensory_box; TIGR00229 760192012771 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 760192012772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192012773 Walker A motif; other site 760192012774 ATP binding site [chemical binding]; other site 760192012775 Walker B motif; other site 760192012776 arginine finger; other site 760192012777 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760192012778 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 760192012779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760192012780 DNA-binding site [nucleotide binding]; DNA binding site 760192012781 UTRA domain; Region: UTRA; pfam07702 760192012782 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 760192012783 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 760192012784 tetrameric interface [polypeptide binding]; other site 760192012785 NAD binding site [chemical binding]; other site 760192012786 catalytic residues [active] 760192012787 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 760192012788 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 760192012789 putative NAD(P) binding site [chemical binding]; other site 760192012790 catalytic Zn binding site [ion binding]; other site 760192012791 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 760192012792 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 760192012793 tetramerization interface [polypeptide binding]; other site 760192012794 NAD(P) binding site [chemical binding]; other site 760192012795 catalytic residues [active] 760192012796 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 760192012797 active site 760192012798 intersubunit interface [polypeptide binding]; other site 760192012799 zinc binding site [ion binding]; other site 760192012800 Na+ binding site [ion binding]; other site 760192012801 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 760192012802 RloB-like protein; Region: RloB; pfam13707 760192012803 AAA domain; Region: AAA_21; pfam13304 760192012804 AAA domain; Region: AAA_21; pfam13304 760192012805 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 760192012806 Na binding site [ion binding]; other site 760192012807 Ureide permease; Region: Ureide_permease; pfam07168 760192012808 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760192012809 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 760192012810 substrate binding site [chemical binding]; other site 760192012811 dimer interface [polypeptide binding]; other site 760192012812 ATP binding site [chemical binding]; other site 760192012813 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 760192012814 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 760192012815 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192012816 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 760192012817 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 760192012818 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192012819 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192012820 catalytic residues [active] 760192012821 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 760192012822 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 760192012823 dimerization interface [polypeptide binding]; other site 760192012824 ATP binding site [chemical binding]; other site 760192012825 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 760192012826 dimerization interface [polypeptide binding]; other site 760192012827 ATP binding site [chemical binding]; other site 760192012828 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 760192012829 putative hydrophobic ligand binding site [chemical binding]; other site 760192012830 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192012831 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192012832 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192012833 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 760192012834 active site 760192012835 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192012836 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 760192012837 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 760192012838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192012839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192012840 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 760192012841 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192012842 catalytic loop [active] 760192012843 iron binding site [ion binding]; other site 760192012844 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 760192012845 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192012846 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 760192012847 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 760192012848 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192012849 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192012850 methionine sulfoxide reductase A; Provisional; Region: PRK14054 760192012851 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192012852 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192012853 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 760192012854 XisI protein; Region: XisI; pfam08869 760192012855 XisI protein; Region: XisI; pfam08869 760192012856 XisH protein; Region: XisH; pfam08814 760192012857 MG2 domain; Region: A2M_N; pfam01835 760192012858 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 760192012859 Alpha-2-macroglobulin family; Region: A2M; pfam00207 760192012860 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 760192012861 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 760192012862 Protein of unknown function (DUF419); Region: DUF419; pfam04237 760192012863 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 760192012864 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192012865 Zn binding site [ion binding]; other site 760192012866 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 760192012867 Zn binding site [ion binding]; other site 760192012868 DUF619 domain of various N-acetylglutamate Kinases and N-acetylglutamate Synthases; Region: DUF619-like; cl14605 760192012869 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 760192012870 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 760192012871 putative active site [active] 760192012872 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760192012873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192012874 Walker A/P-loop; other site 760192012875 ATP binding site [chemical binding]; other site 760192012876 Q-loop/lid; other site 760192012877 ABC transporter signature motif; other site 760192012878 Walker B; other site 760192012879 D-loop; other site 760192012880 H-loop/switch region; other site 760192012881 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192012882 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 760192012883 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192012884 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192012885 active site 760192012886 catalytic tetrad [active] 760192012887 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 760192012888 homotrimer interaction site [polypeptide binding]; other site 760192012889 putative active site [active] 760192012890 PIF1-like helicase; Region: PIF1; pfam05970 760192012891 AAA domain; Region: AAA_30; pfam13604 760192012892 Family description; Region: UvrD_C_2; pfam13538 760192012893 Protein of unknown function DUF72; Region: DUF72; pfam01904 760192012894 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 760192012895 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 760192012896 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192012897 catalytic residue [active] 760192012898 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 760192012899 AAA domain; Region: AAA_26; pfam13500 760192012900 Suppressor of forked protein (Suf); Region: Suf; pfam05843 760192012901 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192012902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012903 active site 760192012904 phosphorylation site [posttranslational modification] 760192012905 intermolecular recognition site; other site 760192012906 dimerization interface [polypeptide binding]; other site 760192012907 LytTr DNA-binding domain; Region: LytTR; smart00850 760192012908 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 760192012909 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 760192012910 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 760192012911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192012912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192012913 dimer interface [polypeptide binding]; other site 760192012914 phosphorylation site [posttranslational modification] 760192012915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192012916 ATP binding site [chemical binding]; other site 760192012917 Mg2+ binding site [ion binding]; other site 760192012918 G-X-G motif; other site 760192012919 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192012920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012921 active site 760192012922 phosphorylation site [posttranslational modification] 760192012923 intermolecular recognition site; other site 760192012924 dimerization interface [polypeptide binding]; other site 760192012925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192012926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192012927 TPR motif; other site 760192012928 binding surface 760192012929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192012930 dimer interface [polypeptide binding]; other site 760192012931 phosphorylation site [posttranslational modification] 760192012932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192012933 ATP binding site [chemical binding]; other site 760192012934 Mg2+ binding site [ion binding]; other site 760192012935 G-X-G motif; other site 760192012936 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192012937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012938 active site 760192012939 phosphorylation site [posttranslational modification] 760192012940 intermolecular recognition site; other site 760192012941 dimerization interface [polypeptide binding]; other site 760192012942 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192012943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012944 active site 760192012945 phosphorylation site [posttranslational modification] 760192012946 intermolecular recognition site; other site 760192012947 dimerization interface [polypeptide binding]; other site 760192012948 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 760192012949 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760192012950 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 760192012951 inhibitor-cofactor binding pocket; inhibition site 760192012952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192012953 catalytic residue [active] 760192012954 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08439 760192012955 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 760192012956 active site 760192012957 biotin synthase; Region: bioB; TIGR00433 760192012958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192012959 FeS/SAM binding site; other site 760192012960 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 760192012961 triosephosphate isomerase; Provisional; Region: PRK14567 760192012962 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 760192012963 substrate binding site [chemical binding]; other site 760192012964 dimer interface [polypeptide binding]; other site 760192012965 catalytic triad [active] 760192012966 Sporulation related domain; Region: SPOR; pfam05036 760192012967 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 760192012968 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 760192012969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012970 active site 760192012971 phosphorylation site [posttranslational modification] 760192012972 intermolecular recognition site; other site 760192012973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192012974 Walker A motif; other site 760192012975 ATP binding site [chemical binding]; other site 760192012976 Walker B motif; other site 760192012977 arginine finger; other site 760192012978 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 760192012979 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760192012980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192012981 active site 760192012982 phosphorylation site [posttranslational modification] 760192012983 intermolecular recognition site; other site 760192012984 dimerization interface [polypeptide binding]; other site 760192012985 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 760192012986 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192012987 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192012988 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192012989 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 760192012990 Glyco_18 domain; Region: Glyco_18; smart00636 760192012991 active site 760192012992 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192012993 putative hydrolase; Provisional; Region: PRK10985 760192012994 Amidohydrolase; Region: Amidohydro_2; pfam04909 760192012995 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 760192012996 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192012997 Putative esterase; Region: Esterase; pfam00756 760192012998 short chain dehydrogenase; Provisional; Region: PRK07326 760192012999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192013000 NAD(P) binding site [chemical binding]; other site 760192013001 active site 760192013002 Cupin domain; Region: Cupin_2; pfam07883 760192013003 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192013004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192013005 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760192013006 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 760192013007 Metal-binding active site; metal-binding site 760192013008 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192013009 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192013010 Trehalose utilisation; Region: ThuA; pfam06283 760192013011 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192013012 HEAT repeats; Region: HEAT_2; pfam13646 760192013013 CARDB; Region: CARDB; pfam07705 760192013014 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 760192013015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 760192013016 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 760192013017 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192013018 active site 760192013019 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 760192013020 hypothetical protein; Provisional; Region: PRK06753 760192013021 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 760192013022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192013023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192013024 Bacterial transcriptional repressor; Region: TetR; pfam13972 760192013025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192013026 Coenzyme A binding pocket [chemical binding]; other site 760192013027 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 760192013028 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013029 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192013030 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192013031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192013032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192013033 dimer interface [polypeptide binding]; other site 760192013034 phosphorylation site [posttranslational modification] 760192013035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192013036 ATP binding site [chemical binding]; other site 760192013037 Mg2+ binding site [ion binding]; other site 760192013038 G-X-G motif; other site 760192013039 Response regulator receiver domain; Region: Response_reg; pfam00072 760192013040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192013041 active site 760192013042 phosphorylation site [posttranslational modification] 760192013043 intermolecular recognition site; other site 760192013044 dimerization interface [polypeptide binding]; other site 760192013045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192013046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192013047 Family description; Region: VCBS; pfam13517 760192013048 Family description; Region: VCBS; pfam13517 760192013049 Family description; Region: VCBS; pfam13517 760192013050 Family description; Region: VCBS; pfam13517 760192013051 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 760192013052 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192013053 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192013054 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192013055 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192013056 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192013057 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760192013058 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760192013059 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192013060 Cupin domain; Region: Cupin_2; pfam07883 760192013061 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 760192013062 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 760192013063 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 760192013064 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192013065 catalytic loop [active] 760192013066 iron binding site [ion binding]; other site 760192013067 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 760192013068 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 760192013069 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 760192013070 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760192013071 MoxR-like ATPases [General function prediction only]; Region: COG0714 760192013072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192013073 Walker A motif; other site 760192013074 ATP binding site [chemical binding]; other site 760192013075 Walker B motif; other site 760192013076 arginine finger; other site 760192013077 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 760192013078 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 760192013079 metal ion-dependent adhesion site (MIDAS); other site 760192013080 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 760192013081 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 760192013082 XdhC Rossmann domain; Region: XdhC_C; pfam13478 760192013083 YHS domain; Region: YHS; pfam04945 760192013084 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 760192013085 putative hydrophobic ligand binding site [chemical binding]; other site 760192013086 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192013087 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192013088 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192013089 putative active site [active] 760192013090 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 760192013091 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 760192013092 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192013093 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192013094 ligand binding site [chemical binding]; other site 760192013095 flexible hinge region; other site 760192013096 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 760192013097 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 760192013098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192013099 catalytic loop [active] 760192013100 iron binding site [ion binding]; other site 760192013101 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 760192013102 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 760192013103 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 760192013104 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 760192013105 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 760192013106 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192013107 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192013108 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192013109 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192013110 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192013111 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192013112 SusD family; Region: SusD; pfam07980 760192013113 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760192013114 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 760192013115 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 760192013116 dimerization interface [polypeptide binding]; other site 760192013117 putative active cleft [active] 760192013118 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 760192013119 Pathogenicity locus; Region: Cdd1; pfam11731 760192013120 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 760192013121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 760192013122 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 760192013123 glycerol kinase; Provisional; Region: glpK; PRK00047 760192013124 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 760192013125 N- and C-terminal domain interface [polypeptide binding]; other site 760192013126 active site 760192013127 MgATP binding site [chemical binding]; other site 760192013128 catalytic site [active] 760192013129 metal binding site [ion binding]; metal-binding site 760192013130 glycerol binding site [chemical binding]; other site 760192013131 homotetramer interface [polypeptide binding]; other site 760192013132 homodimer interface [polypeptide binding]; other site 760192013133 FBP binding site [chemical binding]; other site 760192013134 protein IIAGlc interface [polypeptide binding]; other site 760192013135 DDE superfamily endonuclease; Region: DDE_5; cl17874 760192013136 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 760192013137 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 760192013138 YHYH protein; Region: YHYH; pfam14240 760192013139 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013140 Methyltransferase domain; Region: Methyltransf_31; pfam13847 760192013141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192013142 S-adenosylmethionine binding site [chemical binding]; other site 760192013143 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 760192013144 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 760192013145 active site 760192013146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192013147 S-adenosylmethionine binding site [chemical binding]; other site 760192013148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192013149 S-adenosylmethionine binding site [chemical binding]; other site 760192013150 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 760192013151 Fic family protein [Function unknown]; Region: COG3177 760192013152 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 760192013153 Fic/DOC family; Region: Fic; pfam02661 760192013154 CAAX protease self-immunity; Region: Abi; pfam02517 760192013155 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 760192013156 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 760192013157 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 760192013158 SLBB domain; Region: SLBB; pfam10531 760192013159 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 760192013160 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 760192013161 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760192013162 catalytic loop [active] 760192013163 iron binding site [ion binding]; other site 760192013164 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 760192013165 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 760192013166 4Fe-4S binding domain; Region: Fer4; pfam00037 760192013167 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 760192013168 [4Fe-4S] binding site [ion binding]; other site 760192013169 molybdopterin cofactor binding site; other site 760192013170 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 760192013171 molybdopterin cofactor binding site; other site 760192013172 pyruvate phosphate dikinase; Provisional; Region: PRK09279 760192013173 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 760192013174 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 760192013175 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 760192013176 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 760192013177 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 760192013178 hydrophobic ligand binding site; other site 760192013179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192013180 short chain dehydrogenase; Provisional; Region: PRK08267 760192013181 NAD(P) binding site [chemical binding]; other site 760192013182 active site 760192013183 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 760192013184 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 760192013185 acyl-activating enzyme (AAE) consensus motif; other site 760192013186 AMP binding site [chemical binding]; other site 760192013187 active site 760192013188 CoA binding site [chemical binding]; other site 760192013189 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 760192013190 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 760192013191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192013192 Caspase domain; Region: Peptidase_C14; pfam00656 760192013193 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192013194 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192013195 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192013196 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192013197 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192013198 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192013199 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192013200 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192013201 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192013202 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192013203 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192013204 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192013205 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192013206 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013207 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 760192013208 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 760192013209 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 760192013210 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 760192013211 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 760192013212 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 760192013213 active site 760192013214 catalytic site [active] 760192013215 substrate binding site [chemical binding]; other site 760192013216 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 760192013217 ApbE family; Region: ApbE; pfam02424 760192013218 Predicted membrane protein [Function unknown]; Region: COG2259 760192013219 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 760192013220 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 760192013221 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 760192013222 Ligand binding site; other site 760192013223 Putative Catalytic site; other site 760192013224 DXD motif; other site 760192013225 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 760192013226 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 760192013227 Ligand binding site; other site 760192013228 Putative Catalytic site; other site 760192013229 DXD motif; other site 760192013230 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 760192013231 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 760192013232 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 760192013233 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760192013234 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 760192013235 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 760192013236 active site 760192013237 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013238 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013239 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192013240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192013241 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 760192013242 Flavoprotein; Region: Flavoprotein; pfam02441 760192013243 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 760192013244 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 760192013245 ligand binding site [chemical binding]; other site 760192013246 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 760192013247 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 760192013248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760192013249 Gram-negative bacterial tonB protein; Region: TonB; cl10048 760192013250 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 760192013251 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 760192013252 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 760192013253 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 760192013254 LabA_like proteins; Region: LabA_like; cd06167 760192013255 putative metal binding site [ion binding]; other site 760192013256 Uncharacterized conserved protein [Function unknown]; Region: COG1432 760192013257 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 760192013258 RNA-binding motif; other site 760192013259 DNA-binding site [nucleotide binding]; DNA binding site 760192013260 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 760192013261 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 760192013262 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 760192013263 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 760192013264 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 760192013265 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 760192013266 substrate binding site [chemical binding]; other site 760192013267 oxyanion hole (OAH) forming residues; other site 760192013268 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 760192013269 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 760192013270 dimer interface [polypeptide binding]; other site 760192013271 active site 760192013272 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 760192013273 ADP-ribose binding site [chemical binding]; other site 760192013274 dimer interface [polypeptide binding]; other site 760192013275 active site 760192013276 nudix motif; other site 760192013277 metal binding site [ion binding]; metal-binding site 760192013278 Preprotein translocase SecG subunit; Region: SecG; pfam03840 760192013279 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192013280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192013281 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192013282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192013283 binding surface 760192013284 TPR motif; other site 760192013285 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192013286 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192013287 Tetratricopeptide repeat; Region: TPR_10; cl17452 760192013288 CHAT domain; Region: CHAT; pfam12770 760192013289 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192013290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192013291 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192013292 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013293 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 760192013294 Phage Tail Collar Domain; Region: Collar; pfam07484 760192013295 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013296 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192013297 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 760192013298 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 760192013299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192013300 ATP binding site [chemical binding]; other site 760192013301 putative Mg++ binding site [ion binding]; other site 760192013302 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 760192013303 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192013304 nucleotide binding region [chemical binding]; other site 760192013305 ATP-binding site [chemical binding]; other site 760192013306 adenylosuccinate lyase; Provisional; Region: PRK09285 760192013307 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 760192013308 tetramer interface [polypeptide binding]; other site 760192013309 active site 760192013310 AAA domain; Region: AAA_26; pfam13500 760192013311 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 760192013312 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 760192013313 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 760192013314 active site 760192013315 interdomain interaction site; other site 760192013316 putative metal-binding site [ion binding]; other site 760192013317 nucleotide binding site [chemical binding]; other site 760192013318 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 760192013319 domain I; other site 760192013320 DNA binding groove [nucleotide binding] 760192013321 phosphate binding site [ion binding]; other site 760192013322 domain II; other site 760192013323 domain III; other site 760192013324 nucleotide binding site [chemical binding]; other site 760192013325 catalytic site [active] 760192013326 domain IV; other site 760192013327 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 760192013328 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 760192013329 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 760192013330 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 760192013331 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 760192013332 active site 760192013333 metal binding site [ion binding]; metal-binding site 760192013334 hypothetical protein; Provisional; Region: PRK08609 760192013335 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 760192013336 metal binding triad [ion binding]; metal-binding site 760192013337 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 760192013338 active site 760192013339 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 760192013340 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 760192013341 UbiA prenyltransferase family; Region: UbiA; pfam01040 760192013342 TPR repeat; Region: TPR_11; pfam13414 760192013343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192013344 TPR motif; other site 760192013345 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192013346 binding surface 760192013347 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 760192013348 Sporulation related domain; Region: SPOR; pfam05036 760192013349 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 760192013350 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192013351 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 760192013352 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 760192013353 acyl-activating enzyme (AAE) consensus motif; other site 760192013354 active site 760192013355 AMP binding site [chemical binding]; other site 760192013356 CoA binding site [chemical binding]; other site 760192013357 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192013358 Asp-box motif; other site 760192013359 Predicted permeases [General function prediction only]; Region: COG0679 760192013360 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 760192013361 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760192013362 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760192013363 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760192013364 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 760192013365 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 760192013366 Predicted transcriptional regulator [Transcription]; Region: COG5340 760192013367 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 760192013368 Predicted acyl esterases [General function prediction only]; Region: COG2936 760192013369 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 760192013370 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192013371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192013372 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760192013373 catalytic residues [active] 760192013374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192013375 TPR repeat; Region: TPR_11; pfam13414 760192013376 binding surface 760192013377 TPR motif; other site 760192013378 Uncharacterized conserved protein [Function unknown]; Region: COG0397 760192013379 hypothetical protein; Validated; Region: PRK00029 760192013380 HEAT repeats; Region: HEAT_2; pfam13646 760192013381 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192013382 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192013383 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192013384 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192013385 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192013386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192013387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192013388 DNA binding residues [nucleotide binding] 760192013389 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 760192013390 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 760192013391 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 760192013392 Beta-lactamase; Region: Beta-lactamase; cl17358 760192013393 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192013394 Beta-lactamase; Region: Beta-lactamase; cl17358 760192013395 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192013396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 760192013397 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 760192013398 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192013399 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 760192013400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760192013401 active site 760192013402 4Fe-4S binding domain; Region: Fer4_2; pfam12797 760192013403 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 760192013404 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 760192013405 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 760192013406 Cysteine-rich domain; Region: CCG; pfam02754 760192013407 Cysteine-rich domain; Region: CCG; pfam02754 760192013408 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 760192013409 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 760192013410 homodimer interface [polypeptide binding]; other site 760192013411 substrate-cofactor binding pocket; other site 760192013412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192013413 catalytic residue [active] 760192013414 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 760192013415 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 760192013416 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 760192013417 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 760192013418 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760192013419 DDE superfamily endonuclease; Region: DDE_5; cl17874 760192013420 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 760192013421 Bacterial sugar transferase; Region: Bac_transf; pfam02397 760192013422 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192013423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192013424 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 760192013425 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192013426 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 760192013427 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192013428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192013429 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760192013430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 760192013431 active site 760192013432 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 760192013433 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 760192013434 active site 760192013435 dimer interface [polypeptide binding]; other site 760192013436 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 760192013437 Ligand Binding Site [chemical binding]; other site 760192013438 Molecular Tunnel; other site 760192013439 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 760192013440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192013441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192013442 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760192013443 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 760192013444 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 760192013445 inhibitor-cofactor binding pocket; inhibition site 760192013446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192013447 catalytic residue [active] 760192013448 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 760192013449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192013450 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 760192013451 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 760192013452 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 760192013453 NAD binding site [chemical binding]; other site 760192013454 homotetramer interface [polypeptide binding]; other site 760192013455 homodimer interface [polypeptide binding]; other site 760192013456 substrate binding site [chemical binding]; other site 760192013457 active site 760192013458 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 760192013459 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 760192013460 Methyltransferase domain; Region: Methyltransf_23; pfam13489 760192013461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192013462 S-adenosylmethionine binding site [chemical binding]; other site 760192013463 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 760192013464 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 760192013465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760192013466 active site 760192013467 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 760192013468 TrkA-N domain; Region: TrkA_N; pfam02254 760192013469 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 760192013470 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 760192013471 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 760192013472 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 760192013473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192013474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192013475 catalytic residue [active] 760192013476 Methyltransferase domain; Region: Methyltransf_31; pfam13847 760192013477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192013478 S-adenosylmethionine binding site [chemical binding]; other site 760192013479 M28 Zn-Peptidases; Region: M28_like_3; cd05644 760192013480 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 760192013481 active site 760192013482 metal binding site [ion binding]; metal-binding site 760192013483 Right handed beta helix region; Region: Beta_helix; pfam13229 760192013484 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 760192013485 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 760192013486 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 760192013487 NADP-binding site; other site 760192013488 homotetramer interface [polypeptide binding]; other site 760192013489 substrate binding site [chemical binding]; other site 760192013490 homodimer interface [polypeptide binding]; other site 760192013491 active site 760192013492 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 760192013493 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 760192013494 NADP binding site [chemical binding]; other site 760192013495 active site 760192013496 putative substrate binding site [chemical binding]; other site 760192013497 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 760192013498 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 760192013499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192013500 S-adenosylmethionine binding site [chemical binding]; other site 760192013501 Cupin domain; Region: Cupin_2; pfam07883 760192013502 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 760192013503 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 760192013504 metal ion-dependent adhesion site (MIDAS); other site 760192013505 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 760192013506 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 760192013507 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 760192013508 non-specific DNA binding site [nucleotide binding]; other site 760192013509 salt bridge; other site 760192013510 sequence-specific DNA binding site [nucleotide binding]; other site 760192013511 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 760192013512 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192013513 Low molecular weight phosphatase family; Region: LMWPc; cl00105 760192013514 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 760192013515 active site 760192013516 putative transposase OrfB; Reviewed; Region: PHA02517 760192013517 Integrase core domain; Region: rve; pfam00665 760192013518 Integrase core domain; Region: rve_3; pfam13683 760192013519 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 760192013520 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192013521 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192013522 SusD family; Region: SusD; pfam07980 760192013523 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192013524 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192013525 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192013526 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192013527 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760192013528 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760192013529 Walker A/P-loop; other site 760192013530 ATP binding site [chemical binding]; other site 760192013531 Q-loop/lid; other site 760192013532 ABC transporter signature motif; other site 760192013533 Walker B; other site 760192013534 D-loop; other site 760192013535 H-loop/switch region; other site 760192013536 Kelch motif; Region: Kelch_6; pfam13964 760192013537 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 760192013538 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 760192013539 Kelch motif; Region: Kelch_1; pfam01344 760192013540 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 760192013541 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 760192013542 dimer interface [polypeptide binding]; other site 760192013543 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192013544 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 760192013545 dimer interface [polypeptide binding]; other site 760192013546 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192013547 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 760192013548 dimer interface [polypeptide binding]; other site 760192013549 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 760192013550 putative hydrophobic ligand binding site [chemical binding]; other site 760192013551 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192013552 putative active site [active] 760192013553 XisI protein; Region: XisI; pfam08869 760192013554 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 760192013555 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 760192013556 Hemerythrin-like domain; Region: Hr-like; cd12108 760192013557 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 760192013558 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760192013559 Walker A/P-loop; other site 760192013560 ATP binding site [chemical binding]; other site 760192013561 Q-loop/lid; other site 760192013562 ABC transporter signature motif; other site 760192013563 Walker B; other site 760192013564 D-loop; other site 760192013565 H-loop/switch region; other site 760192013566 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 760192013567 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 760192013568 NosL; Region: NosL; cl01769 760192013569 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 760192013570 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 760192013571 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 760192013572 Fasciclin domain; Region: Fasciclin; pfam02469 760192013573 Rrf2 family protein; Region: rrf2_super; TIGR00738 760192013574 Transcriptional regulator; Region: Rrf2; pfam02082 760192013575 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192013576 LysE type translocator; Region: LysE; cl00565 760192013577 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 760192013578 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 760192013579 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 760192013580 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 760192013581 RNA binding site [nucleotide binding]; other site 760192013582 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 760192013583 putative FMN binding site [chemical binding]; other site 760192013584 Pirin-related protein [General function prediction only]; Region: COG1741 760192013585 Pirin; Region: Pirin; pfam02678 760192013586 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 760192013587 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192013588 putative active site [active] 760192013589 putative NTP binding site [chemical binding]; other site 760192013590 putative nucleic acid binding site [nucleotide binding]; other site 760192013591 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 760192013592 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192013593 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192013594 ligand binding site [chemical binding]; other site 760192013595 flexible hinge region; other site 760192013596 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192013597 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192013598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192013599 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192013600 DNA binding residues [nucleotide binding] 760192013601 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 760192013602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192013603 Coenzyme A binding pocket [chemical binding]; other site 760192013604 Caspase domain; Region: Peptidase_C14; pfam00656 760192013605 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 760192013606 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192013607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192013608 Histidine kinase; Region: HisKA_3; pfam07730 760192013609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192013610 Mg2+ binding site [ion binding]; other site 760192013611 G-X-G motif; other site 760192013612 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192013613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192013614 active site 760192013615 phosphorylation site [posttranslational modification] 760192013616 intermolecular recognition site; other site 760192013617 dimerization interface [polypeptide binding]; other site 760192013618 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 760192013619 dimerization interface [polypeptide binding]; other site 760192013620 DNA binding residues [nucleotide binding] 760192013621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192013622 binding surface 760192013623 TPR motif; other site 760192013624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192013625 TPR motif; other site 760192013626 binding surface 760192013627 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 760192013628 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 760192013629 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013630 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 760192013631 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 760192013632 Sulfatase; Region: Sulfatase; pfam00884 760192013633 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192013634 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013635 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 760192013636 SdpI/YhfL protein family; Region: SdpI; pfam13630 760192013637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192013638 dimerization interface [polypeptide binding]; other site 760192013639 putative DNA binding site [nucleotide binding]; other site 760192013640 putative Zn2+ binding site [ion binding]; other site 760192013641 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192013642 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 760192013643 CHAT domain; Region: CHAT; cl17868 760192013644 CHAT domain; Region: CHAT; cl17868 760192013645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760192013646 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 760192013647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 760192013648 dimerization interface [polypeptide binding]; other site 760192013649 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 760192013650 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 760192013651 dimer interface [polypeptide binding]; other site 760192013652 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 760192013653 active site 760192013654 Fe binding site [ion binding]; other site 760192013655 Family of unknown function (DUF490); Region: DUF490; pfam04357 760192013656 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 760192013657 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 760192013658 Tetramer interface [polypeptide binding]; other site 760192013659 active site 760192013660 FMN-binding site [chemical binding]; other site 760192013661 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 760192013662 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 760192013663 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 760192013664 Predicted membrane protein [Function unknown]; Region: COG4270 760192013665 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 760192013666 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 760192013667 putative metal binding site [ion binding]; other site 760192013668 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 760192013669 Protein of unknown function, DUF258; Region: DUF258; pfam03193 760192013670 PA14 domain; Region: PA14; cl08459 760192013671 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 760192013672 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 760192013673 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 760192013674 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 760192013675 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 760192013676 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 760192013677 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 760192013678 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 760192013679 dimer interface [polypeptide binding]; other site 760192013680 active site 760192013681 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 760192013682 active site 760192013683 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 760192013684 dimerization interface [polypeptide binding]; other site 760192013685 putative active cleft [active] 760192013686 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 760192013687 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 760192013688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192013689 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 760192013690 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192013691 DNA binding residues [nucleotide binding] 760192013692 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013693 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 760192013694 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 760192013695 RNase E interface [polypeptide binding]; other site 760192013696 trimer interface [polypeptide binding]; other site 760192013697 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 760192013698 RNase E interface [polypeptide binding]; other site 760192013699 trimer interface [polypeptide binding]; other site 760192013700 active site 760192013701 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 760192013702 putative nucleic acid binding region [nucleotide binding]; other site 760192013703 G-X-X-G motif; other site 760192013704 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 760192013705 RNA binding site [nucleotide binding]; other site 760192013706 domain interface; other site 760192013707 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 760192013708 16S/18S rRNA binding site [nucleotide binding]; other site 760192013709 S13e-L30e interaction site [polypeptide binding]; other site 760192013710 25S rRNA binding site [nucleotide binding]; other site 760192013711 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 760192013712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192013713 NAD(P) binding site [chemical binding]; other site 760192013714 active site 760192013715 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192013716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192013717 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 760192013718 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 760192013719 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 760192013720 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 760192013721 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 760192013722 NAD binding site [chemical binding]; other site 760192013723 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 760192013724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192013725 ATP binding site [chemical binding]; other site 760192013726 putative Mg++ binding site [ion binding]; other site 760192013727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192013728 nucleotide binding region [chemical binding]; other site 760192013729 ATP-binding site [chemical binding]; other site 760192013730 Restriction endonuclease XhoI; Region: XhoI; pfam04555 760192013731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192013732 S-adenosylmethionine binding site [chemical binding]; other site 760192013733 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192013734 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192013735 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192013736 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192013737 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192013738 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192013739 SusD family; Region: SusD; pfam07980 760192013740 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 760192013741 Bacterial Ig-like domain (DUF1927); Region: DUF1927; pfam09099 760192013742 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 760192013743 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 760192013744 Peptidase family U32; Region: Peptidase_U32; pfam01136 760192013745 Collagenase; Region: DUF3656; pfam12392 760192013746 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192013747 FtsX-like permease family; Region: FtsX; pfam02687 760192013748 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192013749 FtsX-like permease family; Region: FtsX; pfam02687 760192013750 recombination protein F; Reviewed; Region: recF; PRK00064 760192013751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192013752 Walker A/P-loop; other site 760192013753 ATP binding site [chemical binding]; other site 760192013754 Q-loop/lid; other site 760192013755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192013756 ABC transporter signature motif; other site 760192013757 Walker B; other site 760192013758 D-loop; other site 760192013759 H-loop/switch region; other site 760192013760 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 760192013761 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 760192013762 tetramer interface [polypeptide binding]; other site 760192013763 TPP-binding site [chemical binding]; other site 760192013764 heterodimer interface [polypeptide binding]; other site 760192013765 phosphorylation loop region [posttranslational modification] 760192013766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192013767 binding surface 760192013768 TPR motif; other site 760192013769 Tetratricopeptide repeat; Region: TPR_16; pfam13432 760192013770 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 760192013771 homopentamer interface [polypeptide binding]; other site 760192013772 active site 760192013773 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 760192013774 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 760192013775 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 760192013776 dimerization interface [polypeptide binding]; other site 760192013777 active site 760192013778 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 760192013779 Bacterial SH3 domain; Region: SH3_3; pfam08239 760192013780 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 760192013781 NlpC/P60 family; Region: NLPC_P60; pfam00877 760192013782 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192013783 putative active site [active] 760192013784 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192013785 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192013786 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192013787 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192013788 structural tetrad; other site 760192013789 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192013790 Winged helix-turn helix; Region: HTH_29; pfam13551 760192013791 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192013792 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192013793 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192013794 structural tetrad; other site 760192013795 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 760192013796 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192013797 FtsX-like permease family; Region: FtsX; pfam02687 760192013798 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192013799 FtsX-like permease family; Region: FtsX; pfam02687 760192013800 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 760192013801 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192013802 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192013803 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192013804 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192013805 catalytic residues [active] 760192013806 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192013807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192013808 active site 760192013809 phosphorylation site [posttranslational modification] 760192013810 intermolecular recognition site; other site 760192013811 dimerization interface [polypeptide binding]; other site 760192013812 LytTr DNA-binding domain; Region: LytTR; smart00850 760192013813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 760192013814 Histidine kinase; Region: HisKA_2; pfam07568 760192013815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192013816 ATP binding site [chemical binding]; other site 760192013817 Mg2+ binding site [ion binding]; other site 760192013818 G-X-G motif; other site 760192013819 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 760192013820 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 760192013821 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 760192013822 dimerization interface [polypeptide binding]; other site 760192013823 mannose binding site [chemical binding]; other site 760192013824 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 760192013825 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 760192013826 active site 760192013827 D-mannose binding lectin; Region: B_lectin; pfam01453 760192013828 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192013829 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192013830 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192013831 N-terminal plug; other site 760192013832 ligand-binding site [chemical binding]; other site 760192013833 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760192013834 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192013835 active site 760192013836 metal binding site [ion binding]; metal-binding site 760192013837 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 760192013838 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 760192013839 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 760192013840 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 760192013841 putative NAD(P) binding site [chemical binding]; other site 760192013842 catalytic Zn binding site [ion binding]; other site 760192013843 structural Zn binding site [ion binding]; other site 760192013844 Haemolysin-III related; Region: HlyIII; cl03831 760192013845 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 760192013846 AAA domain; Region: AAA_22; pfam13401 760192013847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192013848 Walker A motif; other site 760192013849 ATP binding site [chemical binding]; other site 760192013850 Walker B motif; other site 760192013851 Family description; Region: UvrD_C_2; pfam13538 760192013852 HRDC domain; Region: HRDC; pfam00570 760192013853 Predicted transcriptional regulators [Transcription]; Region: COG1318 760192013854 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192013855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192013856 binding surface 760192013857 TPR motif; other site 760192013858 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192013859 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192013860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192013861 TPR motif; other site 760192013862 binding surface 760192013863 CHAT domain; Region: CHAT; pfam12770 760192013864 Peptidase C10 family; Region: Peptidase_C10; pfam01640 760192013865 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013866 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 760192013867 putative sugar binding sites [chemical binding]; other site 760192013868 Q-X-W motif; other site 760192013869 Family of unknown function (DUF706); Region: DUF706; pfam05153 760192013870 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 760192013871 putative transporter; Provisional; Region: PRK10484 760192013872 Na binding site [ion binding]; other site 760192013873 substrate binding site [chemical binding]; other site 760192013874 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192013875 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 760192013876 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192013877 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 760192013878 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192013879 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192013880 Uncharacterized conserved protein [Function unknown]; Region: COG1739 760192013881 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 760192013882 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 760192013883 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 760192013884 TPR repeat; Region: TPR_11; pfam13414 760192013885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192013886 binding surface 760192013887 TPR motif; other site 760192013888 TPR repeat; Region: TPR_11; pfam13414 760192013889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192013890 binding surface 760192013891 TPR motif; other site 760192013892 TPR repeat; Region: TPR_11; pfam13414 760192013893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192013894 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 760192013895 NAD(P) binding site [chemical binding]; other site 760192013896 active site 760192013897 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192013898 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192013899 catalytic residues [active] 760192013900 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 760192013901 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 760192013902 substrate binding site [chemical binding]; other site 760192013903 active site 760192013904 Predicted membrane protein [Function unknown]; Region: COG3650 760192013905 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 760192013906 Response regulator receiver domain; Region: Response_reg; pfam00072 760192013907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192013908 active site 760192013909 phosphorylation site [posttranslational modification] 760192013910 intermolecular recognition site; other site 760192013911 dimerization interface [polypeptide binding]; other site 760192013912 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 760192013913 cyclase homology domain; Region: CHD; cd07302 760192013914 nucleotidyl binding site; other site 760192013915 metal binding site [ion binding]; metal-binding site 760192013916 dimer interface [polypeptide binding]; other site 760192013917 Response regulator receiver domain; Region: Response_reg; pfam00072 760192013918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192013919 active site 760192013920 phosphorylation site [posttranslational modification] 760192013921 intermolecular recognition site; other site 760192013922 dimerization interface [polypeptide binding]; other site 760192013923 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 760192013924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192013925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192013926 dimer interface [polypeptide binding]; other site 760192013927 phosphorylation site [posttranslational modification] 760192013928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192013929 ATP binding site [chemical binding]; other site 760192013930 Mg2+ binding site [ion binding]; other site 760192013931 G-X-G motif; other site 760192013932 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 760192013933 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 760192013934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192013935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192013936 dimer interface [polypeptide binding]; other site 760192013937 phosphorylation site [posttranslational modification] 760192013938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192013939 ATP binding site [chemical binding]; other site 760192013940 Mg2+ binding site [ion binding]; other site 760192013941 G-X-G motif; other site 760192013942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192013943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192013944 putative substrate translocation pore; other site 760192013945 YCII-related domain; Region: YCII; cl00999 760192013946 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 760192013947 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192013948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192013949 S-adenosylmethionine binding site [chemical binding]; other site 760192013950 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192013951 Predicted membrane protein [Function unknown]; Region: COG2311 760192013952 Protein of unknown function (DUF418); Region: DUF418; cl12135 760192013953 Protein of unknown function (DUF418); Region: DUF418; pfam04235 760192013954 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 760192013955 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 760192013956 homodimer interface [polypeptide binding]; other site 760192013957 substrate-cofactor binding pocket; other site 760192013958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192013959 catalytic residue [active] 760192013960 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 760192013961 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 760192013962 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 760192013963 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 760192013964 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 760192013965 XdhC Rossmann domain; Region: XdhC_C; pfam13478 760192013966 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 760192013967 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 760192013968 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 760192013969 Ca binding site [ion binding]; other site 760192013970 active site 760192013971 homodimer interface [polypeptide binding]; other site 760192013972 catalytic site [active] 760192013973 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 760192013974 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 760192013975 homotrimer interaction site [polypeptide binding]; other site 760192013976 putative active site [active] 760192013977 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192013978 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192013979 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192013980 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 760192013981 Uncharacterized conserved protein [Function unknown]; Region: COG5276 760192013982 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192013983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192013984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192013985 DNA binding residues [nucleotide binding] 760192013986 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 760192013987 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 760192013988 DNA gyrase subunit A; Validated; Region: PRK05560 760192013989 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 760192013990 CAP-like domain; other site 760192013991 active site 760192013992 primary dimer interface [polypeptide binding]; other site 760192013993 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760192013994 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760192013995 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760192013996 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760192013997 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760192013998 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 760192013999 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 760192014000 ATP binding site [chemical binding]; other site 760192014001 Mg++ binding site [ion binding]; other site 760192014002 motif III; other site 760192014003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192014004 nucleotide binding region [chemical binding]; other site 760192014005 ATP-binding site [chemical binding]; other site 760192014006 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 760192014007 Domain of unknown function DUF20; Region: UPF0118; pfam01594 760192014008 Bacterial Ig-like domain; Region: Big_5; pfam13205 760192014009 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192014010 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 760192014011 ligand binding site [chemical binding]; other site 760192014012 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192014013 ligand binding site [chemical binding]; other site 760192014014 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 760192014015 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760192014016 TAP-like protein; Region: Abhydrolase_4; pfam08386 760192014017 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 760192014018 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 760192014019 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192014020 putative homodimer interface [polypeptide binding]; other site 760192014021 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 760192014022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192014023 UDP-galactopyranose mutase; Region: GLF; pfam03275 760192014024 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 760192014025 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 760192014026 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014027 YtxH-like protein; Region: YtxH; pfam12732 760192014028 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 760192014029 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 760192014030 putative ligand binding site [chemical binding]; other site 760192014031 putative NAD binding site [chemical binding]; other site 760192014032 catalytic site [active] 760192014033 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192014034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192014035 PAS fold; Region: PAS_4; pfam08448 760192014036 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 760192014037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192014038 putative active site [active] 760192014039 heme pocket [chemical binding]; other site 760192014040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192014041 dimer interface [polypeptide binding]; other site 760192014042 phosphorylation site [posttranslational modification] 760192014043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192014044 ATP binding site [chemical binding]; other site 760192014045 Mg2+ binding site [ion binding]; other site 760192014046 G-X-G motif; other site 760192014047 Response regulator receiver domain; Region: Response_reg; pfam00072 760192014048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192014049 active site 760192014050 phosphorylation site [posttranslational modification] 760192014051 intermolecular recognition site; other site 760192014052 dimerization interface [polypeptide binding]; other site 760192014053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192014054 active site 760192014055 phosphorylation site [posttranslational modification] 760192014056 intermolecular recognition site; other site 760192014057 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 760192014058 hydroperoxidase II; Provisional; Region: katE; PRK11249 760192014059 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 760192014060 tetramer interface [polypeptide binding]; other site 760192014061 heme binding pocket [chemical binding]; other site 760192014062 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 760192014063 domain interactions; other site 760192014064 Domain of unknown function (DUF305); Region: DUF305; pfam03713 760192014065 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192014066 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192014067 ligand binding site [chemical binding]; other site 760192014068 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192014069 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192014070 Ligand Binding Site [chemical binding]; other site 760192014071 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760192014072 Ligand Binding Site [chemical binding]; other site 760192014073 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 760192014074 dimerization interface [polypeptide binding]; other site 760192014075 metal binding site [ion binding]; metal-binding site 760192014076 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 760192014077 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192014078 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192014079 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192014080 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 760192014081 active site 760192014082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760192014083 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 760192014084 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192014085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192014086 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 760192014087 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 760192014088 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192014089 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192014090 DNA binding residues [nucleotide binding] 760192014091 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 760192014092 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192014093 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 760192014094 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 760192014095 folate binding site [chemical binding]; other site 760192014096 NADP+ binding site [chemical binding]; other site 760192014097 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192014098 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192014099 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192014100 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 760192014101 CTP synthetase; Validated; Region: pyrG; PRK05380 760192014102 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 760192014103 Catalytic site [active] 760192014104 active site 760192014105 UTP binding site [chemical binding]; other site 760192014106 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 760192014107 active site 760192014108 putative oxyanion hole; other site 760192014109 catalytic triad [active] 760192014110 Aspartyl protease; Region: Asp_protease_2; pfam13650 760192014111 inhibitor binding site; inhibition site 760192014112 catalytic motif [active] 760192014113 Catalytic residue [active] 760192014114 Active site flap [active] 760192014115 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 760192014116 catalytic motif [active] 760192014117 Catalytic residue [active] 760192014118 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014119 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192014120 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192014121 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192014122 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 760192014123 arsenical-resistance protein; Region: acr3; TIGR00832 760192014124 Low molecular weight phosphatase family; Region: LMWPc; cd00115 760192014125 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 760192014126 active site 760192014127 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 760192014128 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192014129 active site 760192014130 metal binding site [ion binding]; metal-binding site 760192014131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192014132 putative DNA binding site [nucleotide binding]; other site 760192014133 putative Zn2+ binding site [ion binding]; other site 760192014134 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 760192014135 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 760192014136 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014137 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 760192014138 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 760192014139 Isochorismatase family; Region: Isochorismatase; pfam00857 760192014140 catalytic triad [active] 760192014141 metal binding site [ion binding]; metal-binding site 760192014142 conserved cis-peptide bond; other site 760192014143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192014144 binding surface 760192014145 TPR motif; other site 760192014146 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 760192014147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192014148 binding surface 760192014149 TPR motif; other site 760192014150 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192014151 Family description; Region: VCBS; pfam13517 760192014152 Family description; Region: VCBS; pfam13517 760192014153 Family description; Region: VCBS; pfam13517 760192014154 Family description; Region: VCBS; pfam13517 760192014155 FG-GAP repeat; Region: FG-GAP; pfam01839 760192014156 Family description; Region: VCBS; pfam13517 760192014157 FG-GAP repeat; Region: FG-GAP; pfam01839 760192014158 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014159 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 760192014160 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 760192014161 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 760192014162 putative active site [active] 760192014163 DNA primase, catalytic core; Region: dnaG; TIGR01391 760192014164 CHC2 zinc finger; Region: zf-CHC2; pfam01807 760192014165 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 760192014166 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 760192014167 active site 760192014168 metal binding site [ion binding]; metal-binding site 760192014169 interdomain interaction site; other site 760192014170 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 760192014171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192014172 Walker A/P-loop; other site 760192014173 ATP binding site [chemical binding]; other site 760192014174 ABC transporter signature motif; other site 760192014175 Walker B; other site 760192014176 D-loop; other site 760192014177 H-loop/switch region; other site 760192014178 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192014179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192014180 Walker A/P-loop; other site 760192014181 ATP binding site [chemical binding]; other site 760192014182 Q-loop/lid; other site 760192014183 ABC transporter signature motif; other site 760192014184 Walker B; other site 760192014185 D-loop; other site 760192014186 H-loop/switch region; other site 760192014187 benzoate transport; Region: 2A0115; TIGR00895 760192014188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192014189 putative substrate translocation pore; other site 760192014190 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014191 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 760192014192 Cna protein B-type domain; Region: Cna_B; pfam05738 760192014193 Cna protein B-type domain; Region: Cna_B; pfam05738 760192014194 Cna protein B-type domain; Region: Cna_B; pfam05738 760192014195 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192014196 dockerin binding interface; other site 760192014197 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 760192014198 Domain of unknown function DUF87; Region: DUF87; pfam01935 760192014199 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 760192014200 Zonular occludens toxin (Zot); Region: Zot; cl17485 760192014201 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 760192014202 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 760192014203 active site 760192014204 substrate binding site [chemical binding]; other site 760192014205 Mg2+ binding site [ion binding]; other site 760192014206 dephospho-CoA kinase; Region: TIGR00152 760192014207 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 760192014208 CoA-binding site [chemical binding]; other site 760192014209 RloB-like protein; Region: RloB; pfam13707 760192014210 AAA domain; Region: AAA_21; pfam13304 760192014211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192014212 Walker B; other site 760192014213 D-loop; other site 760192014214 H-loop/switch region; other site 760192014215 Predicted transcriptional regulators [Transcription]; Region: COG1695 760192014216 Transcriptional regulator PadR-like family; Region: PadR; cl17335 760192014217 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192014218 FtsX-like permease family; Region: FtsX; pfam02687 760192014219 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192014220 FtsX-like permease family; Region: FtsX; pfam02687 760192014221 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192014222 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192014223 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192014224 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 760192014225 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192014226 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192014227 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014228 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 760192014229 oligomerisation interface [polypeptide binding]; other site 760192014230 mobile loop; other site 760192014231 roof hairpin; other site 760192014232 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 760192014233 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 760192014234 ring oligomerisation interface [polypeptide binding]; other site 760192014235 ATP/Mg binding site [chemical binding]; other site 760192014236 stacking interactions; other site 760192014237 hinge regions; other site 760192014238 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 760192014239 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 760192014240 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 760192014241 Transposase IS200 like; Region: Y1_Tnp; pfam01797 760192014242 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 760192014243 dimer interface [polypeptide binding]; other site 760192014244 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760192014245 ligand binding site [chemical binding]; other site 760192014246 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760192014247 hypothetical protein; Provisional; Region: PRK06446 760192014248 metal binding site [ion binding]; metal-binding site 760192014249 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 760192014250 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014251 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014252 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014253 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014254 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014255 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014256 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014257 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014258 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014259 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014260 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014261 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192014262 Caspase domain; Region: Peptidase_C14; pfam00656 760192014263 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 760192014264 active site 760192014265 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 760192014266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192014267 S-adenosylmethionine binding site [chemical binding]; other site 760192014268 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 760192014269 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 760192014270 active site 760192014271 catalytic triad [active] 760192014272 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 760192014273 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 760192014274 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 760192014275 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 760192014276 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 760192014277 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 760192014278 Histidine kinase; Region: His_kinase; pfam06580 760192014279 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192014280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192014281 active site 760192014282 phosphorylation site [posttranslational modification] 760192014283 intermolecular recognition site; other site 760192014284 dimerization interface [polypeptide binding]; other site 760192014285 LytTr DNA-binding domain; Region: LytTR; smart00850 760192014286 Predicted transcriptional regulator [Transcription]; Region: COG2378 760192014287 HTH domain; Region: HTH_11; pfam08279 760192014288 WYL domain; Region: WYL; pfam13280 760192014289 CotH protein; Region: CotH; pfam08757 760192014290 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 760192014291 hydrophobic ligand binding site; other site 760192014292 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192014293 FeS/SAM binding site; other site 760192014294 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 760192014295 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192014296 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 760192014297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192014298 Coenzyme A binding pocket [chemical binding]; other site 760192014299 hypothetical protein; Provisional; Region: PRK08201 760192014300 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 760192014301 metal binding site [ion binding]; metal-binding site 760192014302 putative dimer interface [polypeptide binding]; other site 760192014303 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 760192014304 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 760192014305 metal binding site [ion binding]; metal-binding site 760192014306 putative dimer interface [polypeptide binding]; other site 760192014307 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192014308 Amidohydrolase; Region: Amidohydro_4; pfam13147 760192014309 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192014310 active site 760192014311 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192014312 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 760192014313 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 760192014314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192014315 S-adenosylmethionine binding site [chemical binding]; other site 760192014316 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 760192014317 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 760192014318 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 760192014319 Ligand Binding Site [chemical binding]; other site 760192014320 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192014321 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192014322 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192014323 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 760192014324 dinuclear metal binding motif [ion binding]; other site 760192014325 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 760192014326 WbqC-like protein family; Region: WbqC; pfam08889 760192014327 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049 760192014328 heterodimerization interface [polypeptide binding]; other site 760192014329 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192014330 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935 760192014331 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014332 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014333 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192014334 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 760192014335 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192014336 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 760192014337 active site 760192014338 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 760192014339 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 760192014340 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 760192014341 homodimer interface [polypeptide binding]; other site 760192014342 NADP binding site [chemical binding]; other site 760192014343 substrate binding site [chemical binding]; other site 760192014344 DinB superfamily; Region: DinB_2; pfam12867 760192014345 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 760192014346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192014347 S-adenosylmethionine binding site [chemical binding]; other site 760192014348 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 760192014349 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192014350 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192014351 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192014352 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 760192014353 Na binding site [ion binding]; other site 760192014354 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 760192014355 hypothetical protein; Provisional; Region: PRK04081 760192014356 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 760192014357 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 760192014358 active site 760192014359 DNA polymerase IV; Validated; Region: PRK02406 760192014360 DNA binding site [nucleotide binding] 760192014361 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192014362 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192014363 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 760192014364 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 760192014365 conserved cys residue [active] 760192014366 carboxylate-amine ligase; Provisional; Region: PRK13515 760192014367 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 760192014368 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760192014369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 760192014370 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192014371 Putative esterase; Region: Esterase; pfam00756 760192014372 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192014373 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 760192014374 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192014375 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192014376 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 760192014377 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192014378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192014379 Predicted permease [General function prediction only]; Region: COG2985 760192014380 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 760192014381 TrkA-C domain; Region: TrkA_C; pfam02080 760192014382 TrkA-C domain; Region: TrkA_C; pfam02080 760192014383 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 760192014384 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 760192014385 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 760192014386 active site 760192014387 HIGH motif; other site 760192014388 dimer interface [polypeptide binding]; other site 760192014389 KMSKS motif; other site 760192014390 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 760192014391 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014392 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 760192014393 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 760192014394 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 760192014395 hexamer interface [polypeptide binding]; other site 760192014396 ligand binding site [chemical binding]; other site 760192014397 putative active site [active] 760192014398 NAD(P) binding site [chemical binding]; other site 760192014399 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 760192014400 active site 2 [active] 760192014401 active site 1 [active] 760192014402 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 760192014403 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 760192014404 CoA-ligase; Region: Ligase_CoA; pfam00549 760192014405 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 760192014406 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 760192014407 putative trimer interface [polypeptide binding]; other site 760192014408 putative CoA binding site [chemical binding]; other site 760192014409 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 760192014410 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192014411 substrate binding pocket [chemical binding]; other site 760192014412 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014413 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192014414 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192014415 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192014416 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192014417 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 760192014418 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 760192014419 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 760192014420 active site 760192014421 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 760192014422 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 760192014423 active site 760192014424 substrate binding site [chemical binding]; other site 760192014425 metal binding site [ion binding]; metal-binding site 760192014426 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 760192014427 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192014428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192014429 catalytic residue [active] 760192014430 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 760192014431 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 760192014432 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192014433 catalytic residue [active] 760192014434 Caspase domain; Region: Peptidase_C14; pfam00656 760192014435 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192014436 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192014437 structural tetrad; other site 760192014438 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 760192014439 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 760192014440 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 760192014441 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014442 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 760192014443 AAA ATPase domain; Region: AAA_16; pfam13191 760192014444 CHAT domain; Region: CHAT; cl17868 760192014445 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 760192014446 CoA-transferase family III; Region: CoA_transf_3; pfam02515 760192014447 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 760192014448 pyruvate kinase; Validated; Region: PRK08187 760192014449 active site 760192014450 domain interfaces; other site 760192014451 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 760192014452 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 760192014453 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 760192014454 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 760192014455 putative active site [active] 760192014456 catalytic site [active] 760192014457 putative metal binding site [ion binding]; other site 760192014458 oligomer interface [polypeptide binding]; other site 760192014459 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192014460 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192014461 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 760192014462 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 760192014463 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192014464 putative active site [active] 760192014465 flavoprotein, HI0933 family; Region: TIGR00275 760192014466 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 760192014467 Penicillinase repressor; Region: Pencillinase_R; pfam03965 760192014468 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 760192014469 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192014470 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 760192014471 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192014472 putative active site [active] 760192014473 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 760192014474 CoenzymeA binding site [chemical binding]; other site 760192014475 subunit interaction site [polypeptide binding]; other site 760192014476 PHB binding site; other site 760192014477 chaperone protein HscA; Provisional; Region: hscA; PRK05183 760192014478 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 760192014479 nucleotide binding site [chemical binding]; other site 760192014480 putative NEF/HSP70 interaction site [polypeptide binding]; other site 760192014481 SBD interface [polypeptide binding]; other site 760192014482 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 760192014483 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 760192014484 dimer interface [polypeptide binding]; other site 760192014485 substrate binding site [chemical binding]; other site 760192014486 metal binding sites [ion binding]; metal-binding site 760192014487 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192014488 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760192014489 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192014490 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192014491 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192014492 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192014493 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192014494 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192014495 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014496 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192014497 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192014498 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192014499 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192014500 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192014501 Interdomain contacts; other site 760192014502 Cytokine receptor motif; other site 760192014503 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 760192014504 Interdomain contacts; other site 760192014505 Cytokine receptor motif; other site 760192014506 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192014507 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014508 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760192014509 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760192014510 DNA binding site [nucleotide binding] 760192014511 domain linker motif; other site 760192014512 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760192014513 dimerization interface [polypeptide binding]; other site 760192014514 ligand binding site [chemical binding]; other site 760192014515 Bacterial Ig-like domain; Region: Big_5; pfam13205 760192014516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192014517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192014518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192014519 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192014520 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 760192014521 SnoaL-like domain; Region: SnoaL_2; pfam12680 760192014522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192014523 TPR motif; other site 760192014524 binding surface 760192014525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192014526 Histidine kinase; Region: HisKA_3; pfam07730 760192014527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192014528 ATP binding site [chemical binding]; other site 760192014529 Mg2+ binding site [ion binding]; other site 760192014530 G-X-G motif; other site 760192014531 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192014532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192014533 active site 760192014534 phosphorylation site [posttranslational modification] 760192014535 intermolecular recognition site; other site 760192014536 dimerization interface [polypeptide binding]; other site 760192014537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192014538 DNA binding residues [nucleotide binding] 760192014539 dimerization interface [polypeptide binding]; other site 760192014540 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 760192014541 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 760192014542 Mechanosensitive ion channel; Region: MS_channel; pfam00924 760192014543 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014544 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 760192014545 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 760192014546 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 760192014547 dockerin binding interface; other site 760192014548 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 760192014549 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192014550 FtsX-like permease family; Region: FtsX; pfam02687 760192014551 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 760192014552 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 760192014553 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 760192014554 Cl binding site [ion binding]; other site 760192014555 oligomer interface [polypeptide binding]; other site 760192014556 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192014557 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192014558 ligand binding site [chemical binding]; other site 760192014559 D-mannonate oxidoreductase; Provisional; Region: PRK08277 760192014560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192014561 NAD(P) binding site [chemical binding]; other site 760192014562 active site 760192014563 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192014564 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192014565 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192014566 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192014567 SusD family; Region: SusD; pfam07980 760192014568 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192014569 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192014570 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192014571 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192014572 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192014573 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192014574 SusD family; Region: SusD; pfam07980 760192014575 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192014576 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192014577 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192014578 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192014579 Cupin domain; Region: Cupin_2; pfam07883 760192014580 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760192014581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192014582 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 760192014583 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760192014584 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760192014585 active site 760192014586 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 760192014587 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760192014588 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 760192014589 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 760192014590 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 760192014591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192014592 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 760192014593 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 760192014594 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 760192014595 active site 760192014596 intersubunit interface [polypeptide binding]; other site 760192014597 zinc binding site [ion binding]; other site 760192014598 Na+ binding site [ion binding]; other site 760192014599 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 760192014600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192014601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192014602 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 760192014603 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 760192014604 active site 760192014605 catalytic residues [active] 760192014606 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 760192014607 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 760192014608 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 760192014609 HEPN domain; Region: HEPN; cl00824 760192014610 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 760192014611 active site 760192014612 SAM binding site [chemical binding]; other site 760192014613 homodimer interface [polypeptide binding]; other site 760192014614 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 760192014615 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 760192014616 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 760192014617 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 760192014618 Active Sites [active] 760192014619 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 760192014620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760192014621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192014622 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 760192014623 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 760192014624 exosortase K; Region: exosort_XrtK; TIGR04287 760192014625 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 760192014626 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 760192014627 active site 760192014628 catalytic residues [active] 760192014629 DNA binding site [nucleotide binding] 760192014630 Int/Topo IB signature motif; other site 760192014631 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 760192014632 amidase catalytic site [active] 760192014633 Zn binding residues [ion binding]; other site 760192014634 substrate binding site [chemical binding]; other site 760192014635 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 760192014636 active site 760192014637 catalytic residues [active] 760192014638 virion protein; Provisional; Region: V; PHA02564 760192014639 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 760192014640 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 760192014641 putative DNA binding helix; other site 760192014642 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192014643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192014644 Walker A/P-loop; other site 760192014645 ATP binding site [chemical binding]; other site 760192014646 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 760192014647 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 760192014648 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 760192014649 cofactor binding site; other site 760192014650 DNA binding site [nucleotide binding] 760192014651 substrate interaction site [chemical binding]; other site 760192014652 Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211 760192014653 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 760192014654 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 760192014655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192014656 non-specific DNA binding site [nucleotide binding]; other site 760192014657 salt bridge; other site 760192014658 sequence-specific DNA binding site [nucleotide binding]; other site 760192014659 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 760192014660 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192014661 Amidohydrolase; Region: Amidohydro_4; pfam13147 760192014662 active site 760192014663 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 760192014664 AAA domain; Region: AAA_33; pfam13671 760192014665 ADP binding site [chemical binding]; other site 760192014666 magnesium binding site [ion binding]; other site 760192014667 putative shikimate binding site; other site 760192014668 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 760192014669 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 760192014670 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 760192014671 tartrate dehydrogenase; Region: TTC; TIGR02089 760192014672 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 760192014673 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 760192014674 active site 760192014675 catalytic residues [active] 760192014676 metal binding site [ion binding]; metal-binding site 760192014677 methionine sulfoxide reductase A; Provisional; Region: PRK14054 760192014678 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 760192014679 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760192014680 catalytic core [active] 760192014681 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 760192014682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760192014683 FeS/SAM binding site; other site 760192014684 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 760192014685 active site 760192014686 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 760192014687 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 760192014688 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 760192014689 polyphosphate kinase; Provisional; Region: PRK05443 760192014690 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 760192014691 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 760192014692 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 760192014693 domain interface [polypeptide binding]; other site 760192014694 active site 760192014695 catalytic site [active] 760192014696 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 760192014697 domain interface [polypeptide binding]; other site 760192014698 active site 760192014699 catalytic site [active] 760192014700 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 760192014701 tandem repeat interface [polypeptide binding]; other site 760192014702 oligomer interface [polypeptide binding]; other site 760192014703 active site residues [active] 760192014704 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 760192014705 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 760192014706 tandem repeat interface [polypeptide binding]; other site 760192014707 oligomer interface [polypeptide binding]; other site 760192014708 active site residues [active] 760192014709 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 760192014710 RimM N-terminal domain; Region: RimM; pfam01782 760192014711 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 760192014712 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 760192014713 Ligand Binding Site [chemical binding]; other site 760192014714 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 760192014715 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 760192014716 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 760192014717 Sporulation related domain; Region: SPOR; pfam05036 760192014718 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 760192014719 B12 binding site [chemical binding]; other site 760192014720 Radical SAM superfamily; Region: Radical_SAM; pfam04055 760192014721 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 760192014722 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760192014723 catalytic residue [active] 760192014724 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 760192014725 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 760192014726 active site 760192014727 dimer interface [polypeptide binding]; other site 760192014728 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 760192014729 dimer interface [polypeptide binding]; other site 760192014730 active site 760192014731 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 760192014732 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192014733 active site 760192014734 metal binding site [ion binding]; metal-binding site 760192014735 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192014736 putative active site [active] 760192014737 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192014738 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 760192014739 Cytochrome c; Region: Cytochrom_C; pfam00034 760192014740 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 760192014741 intersubunit interface [polypeptide binding]; other site 760192014742 active site 760192014743 Zn2+ binding site [ion binding]; other site 760192014744 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 760192014745 Cupin domain; Region: Cupin_2; pfam07883 760192014746 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 760192014747 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192014748 motif II; other site 760192014749 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192014750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192014751 Walker A motif; other site 760192014752 ATP binding site [chemical binding]; other site 760192014753 Walker B motif; other site 760192014754 arginine finger; other site 760192014755 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 760192014756 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 760192014757 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 760192014758 active site 760192014759 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192014760 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192014761 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192014762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192014763 TPR motif; other site 760192014764 binding surface 760192014765 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192014766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192014767 binding surface 760192014768 TPR motif; other site 760192014769 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192014770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192014771 CHAT domain; Region: CHAT; pfam12770 760192014772 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 760192014773 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192014774 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 760192014775 Active_site [active] 760192014776 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 760192014777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760192014778 DNA-binding site [nucleotide binding]; DNA binding site 760192014779 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760192014780 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760192014781 Walker A/P-loop; other site 760192014782 ATP binding site [chemical binding]; other site 760192014783 Q-loop/lid; other site 760192014784 ABC transporter signature motif; other site 760192014785 Walker B; other site 760192014786 D-loop; other site 760192014787 H-loop/switch region; other site 760192014788 Haem-binding domain; Region: Haem_bd; pfam14376 760192014789 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192014790 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 760192014791 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192014792 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 760192014793 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 760192014794 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 760192014795 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 760192014796 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 760192014797 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 760192014798 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 760192014799 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192014800 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 760192014801 active site 760192014802 dimer interface [polypeptide binding]; other site 760192014803 catalytic nucleophile [active] 760192014804 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 760192014805 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 760192014806 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 760192014807 HD domain; Region: HD_4; pfam13328 760192014808 TROVE domain; Region: TROVE; pfam05731 760192014809 WYL domain; Region: WYL; pfam13280 760192014810 Predicted flavoprotein [General function prediction only]; Region: COG0431 760192014811 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760192014812 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 760192014813 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192014814 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192014815 catalytic residue [active] 760192014816 Winged helix-turn helix; Region: HTH_29; pfam13551 760192014817 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192014818 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 760192014819 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 760192014820 Walker A/P-loop; other site 760192014821 ATP binding site [chemical binding]; other site 760192014822 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 760192014823 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 760192014824 ABC transporter signature motif; other site 760192014825 Walker B; other site 760192014826 D-loop; other site 760192014827 H-loop/switch region; other site 760192014828 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 760192014829 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 760192014830 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192014831 BNR repeat-like domain; Region: BNR_2; pfam13088 760192014832 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 760192014833 Asp-box motif; other site 760192014834 catalytic site [active] 760192014835 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 760192014836 FAD binding domain; Region: FAD_binding_4; pfam01565 760192014837 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 760192014838 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 760192014839 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 760192014840 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192014841 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192014842 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192014843 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 760192014844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760192014845 active site 760192014846 motif I; other site 760192014847 motif II; other site 760192014848 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 760192014849 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 760192014850 active site 760192014851 catalytic triad [active] 760192014852 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 760192014853 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 760192014854 active site 760192014855 catalytic site [active] 760192014856 Winged helix-turn helix; Region: HTH_29; pfam13551 760192014857 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192014858 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192014859 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 760192014860 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192014861 N-terminal plug; other site 760192014862 ligand-binding site [chemical binding]; other site 760192014863 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 760192014864 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 760192014865 ATP binding site [chemical binding]; other site 760192014866 substrate interface [chemical binding]; other site 760192014867 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192014868 active site residue [active] 760192014869 acetyl-CoA synthetase; Provisional; Region: PRK00174 760192014870 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 760192014871 active site 760192014872 CoA binding site [chemical binding]; other site 760192014873 acyl-activating enzyme (AAE) consensus motif; other site 760192014874 AMP binding site [chemical binding]; other site 760192014875 acetate binding site [chemical binding]; other site 760192014876 Cytochrome c [Energy production and conversion]; Region: COG3258 760192014877 Cytochrome c; Region: Cytochrom_C; pfam00034 760192014878 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 760192014879 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 760192014880 active site 760192014881 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 760192014882 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 760192014883 RecX family; Region: RecX; pfam02631 760192014884 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 760192014885 Mechanosensitive ion channel; Region: MS_channel; pfam00924 760192014886 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 760192014887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192014888 ATP binding site [chemical binding]; other site 760192014889 putative Mg++ binding site [ion binding]; other site 760192014890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192014891 nucleotide binding region [chemical binding]; other site 760192014892 ATP-binding site [chemical binding]; other site 760192014893 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 760192014894 HRDC domain; Region: HRDC; pfam00570 760192014895 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 760192014896 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192014897 structural tetrad; other site 760192014898 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 760192014899 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 760192014900 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 760192014901 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192014902 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760192014903 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192014904 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 760192014905 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760192014906 signal recognition particle protein; Provisional; Region: PRK10867 760192014907 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 760192014908 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 760192014909 P loop; other site 760192014910 GTP binding site [chemical binding]; other site 760192014911 Signal peptide binding domain; Region: SRP_SPB; pfam02978 760192014912 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192014913 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192014914 ligand binding site [chemical binding]; other site 760192014915 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 760192014916 Uncharacterized conserved protein [Function unknown]; Region: COG3743 760192014917 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 760192014918 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 760192014919 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 760192014920 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 760192014921 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 760192014922 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 760192014923 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 760192014924 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 760192014925 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 760192014926 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 760192014927 Substrate-binding site [chemical binding]; other site 760192014928 Substrate specificity [chemical binding]; other site 760192014929 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 760192014930 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760192014931 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760192014932 Walker A/P-loop; other site 760192014933 ATP binding site [chemical binding]; other site 760192014934 Q-loop/lid; other site 760192014935 ABC transporter signature motif; other site 760192014936 Walker B; other site 760192014937 D-loop; other site 760192014938 H-loop/switch region; other site 760192014939 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192014940 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 760192014941 DNA-binding site [nucleotide binding]; DNA binding site 760192014942 RNA-binding motif; other site 760192014943 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192014944 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192014945 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 760192014946 ATP-grasp domain; Region: ATP-grasp; pfam02222 760192014947 dihydroorotase; Reviewed; Region: PRK09236 760192014948 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192014949 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 760192014950 active site 760192014951 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 760192014952 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192014953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192014954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192014955 DNA binding residues [nucleotide binding] 760192014956 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 760192014957 catalytic site [active] 760192014958 putative active site [active] 760192014959 putative substrate binding site [chemical binding]; other site 760192014960 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 760192014961 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 760192014962 Walker A/P-loop; other site 760192014963 ATP binding site [chemical binding]; other site 760192014964 Q-loop/lid; other site 760192014965 ABC transporter signature motif; other site 760192014966 Walker B; other site 760192014967 D-loop; other site 760192014968 H-loop/switch region; other site 760192014969 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 760192014970 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 760192014971 Walker A/P-loop; other site 760192014972 ATP binding site [chemical binding]; other site 760192014973 Q-loop/lid; other site 760192014974 ABC transporter signature motif; other site 760192014975 Walker B; other site 760192014976 D-loop; other site 760192014977 H-loop/switch region; other site 760192014978 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 760192014979 hypothetical protein; Reviewed; Region: PRK09588 760192014980 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 760192014981 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192014982 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192014983 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192014984 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192014985 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 760192014986 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192014987 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192014988 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192014989 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192014990 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192014991 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 760192014992 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192014993 G1 box; other site 760192014994 GTP/Mg2+ binding site [chemical binding]; other site 760192014995 G2 box; other site 760192014996 Switch I region; other site 760192014997 G3 box; other site 760192014998 Switch II region; other site 760192014999 G4 box; other site 760192015000 G5 box; other site 760192015001 TIR domain; Region: TIR_2; pfam13676 760192015002 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 760192015003 putative active site [active] 760192015004 Protein of unknown function, DUF479; Region: DUF479; cl01203 760192015005 GTP-binding protein YchF; Reviewed; Region: PRK09601 760192015006 YchF GTPase; Region: YchF; cd01900 760192015007 G1 box; other site 760192015008 GTP/Mg2+ binding site [chemical binding]; other site 760192015009 Switch I region; other site 760192015010 G2 box; other site 760192015011 Switch II region; other site 760192015012 G3 box; other site 760192015013 G4 box; other site 760192015014 G5 box; other site 760192015015 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 760192015016 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 760192015017 pseudouridine synthase; Region: TIGR00093 760192015018 active site 760192015019 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 760192015020 active site 760192015021 catalytic site [active] 760192015022 substrate binding site [chemical binding]; other site 760192015023 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 760192015024 putative acyl-acceptor binding pocket; other site 760192015025 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 760192015026 G1 box; other site 760192015027 GTP/Mg2+ binding site [chemical binding]; other site 760192015028 Switch I region; other site 760192015029 G2 box; other site 760192015030 G3 box; other site 760192015031 Switch II region; other site 760192015032 G4 box; other site 760192015033 G5 box; other site 760192015034 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192015035 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 760192015036 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 760192015037 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192015038 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192015039 ligand binding site [chemical binding]; other site 760192015040 Sporulation related domain; Region: SPOR; pfam05036 760192015041 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 760192015042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192015043 AAA domain; Region: AAA_21; pfam13304 760192015044 Walker A/P-loop; other site 760192015045 ATP binding site [chemical binding]; other site 760192015046 TIGR02646 family protein; Region: TIGR02646 760192015047 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 760192015048 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 760192015049 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 760192015050 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 760192015051 CRISPR type III-B/RAMP module RAMP protein Cmr4; Region: cas_RAMP_Cmr4; TIGR02580 760192015052 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 760192015053 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 760192015054 PemK-like protein; Region: PemK; pfam02452 760192015055 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 760192015056 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 760192015057 Sporulation related domain; Region: SPOR; cl10051 760192015058 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192015059 DNA binding residues [nucleotide binding] 760192015060 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192015061 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 760192015062 putative active site [active] 760192015063 putative NTP binding site [chemical binding]; other site 760192015064 putative nucleic acid binding site [nucleotide binding]; other site 760192015065 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 760192015066 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 760192015067 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 760192015068 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 760192015069 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192015070 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192015071 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 760192015072 Phosphotransferase enzyme family; Region: APH; pfam01636 760192015073 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 760192015074 active site 760192015075 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 760192015076 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 760192015077 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 760192015078 putative active site [active] 760192015079 putative metal binding site [ion binding]; other site 760192015080 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 760192015081 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 760192015082 active site 760192015083 catalytic site [active] 760192015084 substrate binding site [chemical binding]; other site 760192015085 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 760192015086 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 760192015087 GIY-YIG motif/motif A; other site 760192015088 active site 760192015089 catalytic site [active] 760192015090 putative DNA binding site [nucleotide binding]; other site 760192015091 metal binding site [ion binding]; metal-binding site 760192015092 TM2 domain; Region: TM2; pfam05154 760192015093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192015094 TPR motif; other site 760192015095 TPR repeat; Region: TPR_11; pfam13414 760192015096 binding surface 760192015097 Short C-terminal domain; Region: SHOCT; pfam09851 760192015098 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 760192015099 Dynamin family; Region: Dynamin_N; pfam00350 760192015100 G1 box; other site 760192015101 GTP/Mg2+ binding site [chemical binding]; other site 760192015102 G2 box; other site 760192015103 Switch I region; other site 760192015104 G3 box; other site 760192015105 Switch II region; other site 760192015106 G4 box; other site 760192015107 G5 box; other site 760192015108 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 760192015109 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 760192015110 dimer interface [polypeptide binding]; other site 760192015111 active site 760192015112 CoA binding pocket [chemical binding]; other site 760192015113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192015114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192015115 active site 760192015116 phosphorylation site [posttranslational modification] 760192015117 intermolecular recognition site; other site 760192015118 dimerization interface [polypeptide binding]; other site 760192015119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192015120 DNA binding residues [nucleotide binding] 760192015121 dimerization interface [polypeptide binding]; other site 760192015122 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192015123 Histidine kinase; Region: HisKA_3; pfam07730 760192015124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192015125 ATP binding site [chemical binding]; other site 760192015126 Mg2+ binding site [ion binding]; other site 760192015127 G-X-G motif; other site 760192015128 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 760192015129 PA/protease or protease-like domain interface [polypeptide binding]; other site 760192015130 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015131 isocitrate dehydrogenase; Reviewed; Region: PRK07006 760192015132 isocitrate dehydrogenase; Validated; Region: PRK07362 760192015133 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 760192015134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192015135 Walker A motif; other site 760192015136 ATP binding site [chemical binding]; other site 760192015137 Walker B motif; other site 760192015138 arginine finger; other site 760192015139 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 760192015140 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 760192015141 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192015142 active site 760192015143 metal binding site [ion binding]; metal-binding site 760192015144 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 760192015145 classical (c) SDRs; Region: SDR_c; cd05233 760192015146 NAD(P) binding site [chemical binding]; other site 760192015147 active site 760192015148 beta-phosphoglucomutase; Region: bPGM; TIGR01990 760192015149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 760192015150 motif II; other site 760192015151 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 760192015152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 760192015153 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015154 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 760192015155 ApbE family; Region: ApbE; pfam02424 760192015156 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760192015157 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 760192015158 active site 760192015159 catalytic triad [active] 760192015160 oxyanion hole [active] 760192015161 Trehalose utilisation; Region: ThuA; pfam06283 760192015162 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 760192015163 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192015164 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192015165 Cytochrome c; Region: Cytochrom_C; cl11414 760192015166 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 760192015167 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 760192015168 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 760192015169 MOSC domain; Region: MOSC; pfam03473 760192015170 Ion transport protein; Region: Ion_trans; pfam00520 760192015171 Ion channel; Region: Ion_trans_2; pfam07885 760192015172 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 760192015173 Double zinc ribbon; Region: DZR; pfam12773 760192015174 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 760192015175 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 760192015176 active site 760192015177 nucleophile elbow; other site 760192015178 Histidine kinase; Region: His_kinase; pfam06580 760192015179 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 760192015180 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192015181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192015182 active site 760192015183 phosphorylation site [posttranslational modification] 760192015184 intermolecular recognition site; other site 760192015185 dimerization interface [polypeptide binding]; other site 760192015186 LytTr DNA-binding domain; Region: LytTR; pfam04397 760192015187 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 760192015188 catalytic motif [active] 760192015189 Catalytic residue [active] 760192015190 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 760192015191 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760192015192 active site 760192015193 metal binding site [ion binding]; metal-binding site 760192015194 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 760192015195 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 760192015196 active site 760192015197 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 760192015198 Amidase; Region: Amidase; pfam01425 760192015199 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 760192015200 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 760192015201 nucleotide binding site [chemical binding]; other site 760192015202 substrate binding site [chemical binding]; other site 760192015203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760192015204 sequence-specific DNA binding site [nucleotide binding]; other site 760192015205 salt bridge; other site 760192015206 Predicted transcriptional regulator [Transcription]; Region: COG2932 760192015207 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760192015208 Catalytic site [active] 760192015209 aspartate aminotransferase; Provisional; Region: PRK07568 760192015210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760192015211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192015212 homodimer interface [polypeptide binding]; other site 760192015213 catalytic residue [active] 760192015214 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 760192015215 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 760192015216 cofactor binding site; other site 760192015217 DNA binding site [nucleotide binding] 760192015218 substrate interaction site [chemical binding]; other site 760192015219 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 760192015220 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 760192015221 membrane protein insertase; Provisional; Region: PRK01318 760192015222 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 760192015223 Preprotein translocase subunit; Region: YajC; pfam02699 760192015224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 760192015225 YbbR-like protein; Region: YbbR; pfam07949 760192015226 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 760192015227 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192015228 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192015229 catalytic residues [active] 760192015230 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 760192015231 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192015232 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192015233 catalytic residues [active] 760192015234 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192015235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192015236 binding surface 760192015237 TPR motif; other site 760192015238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192015239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192015240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 760192015241 dimer interface [polypeptide binding]; other site 760192015242 phosphorylation site [posttranslational modification] 760192015243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192015244 ATP binding site [chemical binding]; other site 760192015245 Mg2+ binding site [ion binding]; other site 760192015246 G-X-G motif; other site 760192015247 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192015248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192015249 active site 760192015250 phosphorylation site [posttranslational modification] 760192015251 intermolecular recognition site; other site 760192015252 dimerization interface [polypeptide binding]; other site 760192015253 LytTr DNA-binding domain; Region: LytTR; smart00850 760192015254 Right handed beta helix region; Region: Beta_helix; pfam13229 760192015255 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015256 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 760192015257 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 760192015258 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 760192015259 PhnA protein; Region: PhnA; pfam03831 760192015260 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 760192015261 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 760192015262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192015263 TPR repeat; Region: TPR_11; pfam13414 760192015264 binding surface 760192015265 TPR motif; other site 760192015266 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192015267 TPR motif; other site 760192015268 binding surface 760192015269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192015270 TPR motif; other site 760192015271 binding surface 760192015272 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192015273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192015274 ATP binding site [chemical binding]; other site 760192015275 Walker A motif; other site 760192015276 Walker B motif; other site 760192015277 arginine finger; other site 760192015278 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 760192015279 active site 760192015280 catalytic residues [active] 760192015281 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 760192015282 Lamin Tail Domain; Region: LTD; pfam00932 760192015283 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 760192015284 YceG-like family; Region: YceG; pfam02618 760192015285 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 760192015286 dimerization interface [polypeptide binding]; other site 760192015287 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 760192015288 active site 760192015289 oligomerization interface [polypeptide binding]; other site 760192015290 metal binding site [ion binding]; metal-binding site 760192015291 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 760192015292 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 760192015293 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 760192015294 FMN binding site [chemical binding]; other site 760192015295 active site 760192015296 substrate binding site [chemical binding]; other site 760192015297 catalytic residue [active] 760192015298 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 760192015299 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 760192015300 Walker A/P-loop; other site 760192015301 ATP binding site [chemical binding]; other site 760192015302 Q-loop/lid; other site 760192015303 ABC transporter signature motif; other site 760192015304 Walker B; other site 760192015305 D-loop; other site 760192015306 H-loop/switch region; other site 760192015307 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 760192015308 Permease; Region: Permease; pfam02405 760192015309 SOUL heme-binding protein; Region: SOUL; pfam04832 760192015310 BON domain; Region: BON; pfam04972 760192015311 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 760192015312 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 760192015313 nucleotide binding site [chemical binding]; other site 760192015314 NEF interaction site [polypeptide binding]; other site 760192015315 SBD interface [polypeptide binding]; other site 760192015316 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 760192015317 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 760192015318 Ligand binding site; other site 760192015319 Putative Catalytic site; other site 760192015320 DXD motif; other site 760192015321 2TM domain; Region: 2TM; pfam13239 760192015322 2TM domain; Region: 2TM; pfam13239 760192015323 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192015324 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192015325 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015326 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 760192015327 Na binding site [ion binding]; other site 760192015328 DNA photolyase; Region: DNA_photolyase; pfam00875 760192015329 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 760192015330 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 760192015331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760192015332 ATP binding site [chemical binding]; other site 760192015333 putative Mg++ binding site [ion binding]; other site 760192015334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192015335 nucleotide binding region [chemical binding]; other site 760192015336 ATP-binding site [chemical binding]; other site 760192015337 DbpA RNA binding domain; Region: DbpA; pfam03880 760192015338 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192015339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192015340 active site 760192015341 phosphorylation site [posttranslational modification] 760192015342 intermolecular recognition site; other site 760192015343 dimerization interface [polypeptide binding]; other site 760192015344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192015345 DNA binding residues [nucleotide binding] 760192015346 dimerization interface [polypeptide binding]; other site 760192015347 TPR repeat; Region: TPR_11; pfam13414 760192015348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192015349 binding surface 760192015350 TPR motif; other site 760192015351 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192015352 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192015353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 760192015354 Histidine kinase; Region: HisKA_2; pfam07568 760192015355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192015356 ATP binding site [chemical binding]; other site 760192015357 Mg2+ binding site [ion binding]; other site 760192015358 G-X-G motif; other site 760192015359 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 760192015360 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 760192015361 Zn binding site [ion binding]; other site 760192015362 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 760192015363 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760192015364 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 760192015365 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 760192015366 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 760192015367 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 760192015368 Ca binding site [ion binding]; other site 760192015369 active site 760192015370 homodimer interface [polypeptide binding]; other site 760192015371 catalytic site [active] 760192015372 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 760192015373 potential frameshift: common BLAST hit: gi|194336771|ref|YP_002018565.1| TPR repeat-containing protein 760192015374 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192015375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192015376 binding surface 760192015377 TPR motif; other site 760192015378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192015379 NB-ARC domain; Region: NB-ARC; pfam00931 760192015380 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192015381 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 760192015382 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192015383 putative active site [active] 760192015384 putative NTP binding site [chemical binding]; other site 760192015385 putative nucleic acid binding site [nucleotide binding]; other site 760192015386 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 760192015387 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 760192015388 Asp-box motif; other site 760192015389 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 760192015390 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192015391 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192015392 ligand binding site [chemical binding]; other site 760192015393 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 760192015394 putative active site [active] 760192015395 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 760192015396 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 760192015397 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 760192015398 Protein export membrane protein; Region: SecD_SecF; pfam02355 760192015399 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 760192015400 BON domain; Region: BON; pfam04972 760192015401 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192015402 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 760192015403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192015404 active site 760192015405 phosphorylation site [posttranslational modification] 760192015406 intermolecular recognition site; other site 760192015407 dimerization interface [polypeptide binding]; other site 760192015408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192015409 DNA binding site [nucleotide binding] 760192015410 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 760192015411 NHAD transporter family protein; Provisional; Region: PLN00137 760192015412 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 760192015413 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 760192015414 putative ligand binding site [chemical binding]; other site 760192015415 putative NAD binding site [chemical binding]; other site 760192015416 catalytic site [active] 760192015417 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 760192015418 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 760192015419 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192015420 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192015421 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192015422 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 760192015423 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 760192015424 Cation efflux family; Region: Cation_efflux; pfam01545 760192015425 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 760192015426 active site 760192015427 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 760192015428 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 760192015429 active site 760192015430 CARDB; Region: CARDB; pfam07705 760192015431 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 760192015432 Cytochrome c; Region: Cytochrom_C; cl11414 760192015433 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192015434 PA14 domain; Region: PA14; cl08459 760192015435 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 760192015436 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 760192015437 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 760192015438 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192015439 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 760192015440 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 760192015441 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 760192015442 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 760192015443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760192015444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192015445 active site 760192015446 phosphorylation site [posttranslational modification] 760192015447 intermolecular recognition site; other site 760192015448 dimerization interface [polypeptide binding]; other site 760192015449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760192015450 DNA binding site [nucleotide binding] 760192015451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760192015452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192015453 dimer interface [polypeptide binding]; other site 760192015454 phosphorylation site [posttranslational modification] 760192015455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192015456 ATP binding site [chemical binding]; other site 760192015457 Mg2+ binding site [ion binding]; other site 760192015458 G-X-G motif; other site 760192015459 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 760192015460 ATP binding site [chemical binding]; other site 760192015461 active site 760192015462 substrate binding site [chemical binding]; other site 760192015463 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 760192015464 active site 760192015465 ligand binding site [chemical binding]; other site 760192015466 NAD(P) binding site [chemical binding]; other site 760192015467 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 760192015468 apolar tunnel; other site 760192015469 heme binding site [chemical binding]; other site 760192015470 dimerization interface [polypeptide binding]; other site 760192015471 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192015472 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192015473 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015474 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 760192015475 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 760192015476 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 760192015477 mannonate dehydratase; Provisional; Region: PRK03906 760192015478 mannonate dehydratase; Region: uxuA; TIGR00695 760192015479 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 760192015480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760192015481 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 760192015482 dimerization interface [polypeptide binding]; other site 760192015483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 760192015484 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 760192015485 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 760192015486 Gram-negative bacterial tonB protein; Region: TonB; cl10048 760192015487 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192015488 FtsX-like permease family; Region: FtsX; pfam02687 760192015489 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760192015490 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 760192015491 active site 760192015492 catalytic triad [active] 760192015493 oxyanion hole [active] 760192015494 Cupin domain; Region: Cupin_2; cl17218 760192015495 Cupin domain; Region: Cupin_2; cl17218 760192015496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 760192015497 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760192015498 Coenzyme A binding pocket [chemical binding]; other site 760192015499 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 760192015500 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 760192015501 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192015502 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192015503 active site 760192015504 catalytic tetrad [active] 760192015505 PLD-like domain; Region: PLDc_2; pfam13091 760192015506 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 760192015507 putative homodimer interface [polypeptide binding]; other site 760192015508 putative active site [active] 760192015509 catalytic site [active] 760192015510 DinB superfamily; Region: DinB_2; pfam12867 760192015511 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 760192015512 active site 760192015513 catalytic triad [active] 760192015514 oxyanion hole [active] 760192015515 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 760192015516 active site 760192015517 catalytic triad [active] 760192015518 oxyanion hole [active] 760192015519 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 760192015520 catalytic site [active] 760192015521 BNR repeat-like domain; Region: BNR_2; pfam13088 760192015522 Asp-box motif; other site 760192015523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 760192015524 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 760192015525 active site 760192015526 catalytic triad [active] 760192015527 oxyanion hole [active] 760192015528 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 760192015529 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192015530 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192015531 Sulfatase; Region: Sulfatase; pfam00884 760192015532 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192015533 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192015534 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192015535 active site 760192015536 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192015537 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 760192015538 Peptidase S46; Region: Peptidase_S46; pfam10459 760192015539 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760192015540 DinB superfamily; Region: DinB_2; pfam12867 760192015541 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 760192015542 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 760192015543 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 760192015544 [2Fe-2S] cluster binding site [ion binding]; other site 760192015545 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 760192015546 hydrophobic ligand binding site; other site 760192015547 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760192015548 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 760192015549 putative ribose interaction site [chemical binding]; other site 760192015550 putative ADP binding site [chemical binding]; other site 760192015551 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 760192015552 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 760192015553 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760192015554 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 760192015555 NAD binding site [chemical binding]; other site 760192015556 putative substrate binding site 2 [chemical binding]; other site 760192015557 putative substrate binding site 1 [chemical binding]; other site 760192015558 active site 760192015559 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 760192015560 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 760192015561 NAD binding site [chemical binding]; other site 760192015562 substrate binding site [chemical binding]; other site 760192015563 homodimer interface [polypeptide binding]; other site 760192015564 active site 760192015565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760192015566 Coenzyme A binding pocket [chemical binding]; other site 760192015567 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 760192015568 active site triad [active] 760192015569 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760192015570 active site 760192015571 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 760192015572 active site 760192015573 Ap6A binding site [chemical binding]; other site 760192015574 nudix motif; other site 760192015575 metal binding site [ion binding]; metal-binding site 760192015576 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 760192015577 dockerin binding interface; other site 760192015578 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 760192015580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192015581 PAS domain; Region: PAS_9; pfam13426 760192015582 putative active site [active] 760192015583 heme pocket [chemical binding]; other site 760192015584 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192015585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192015586 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 760192015587 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 760192015588 active site 760192015589 metal binding site [ion binding]; metal-binding site 760192015590 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 760192015591 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 760192015592 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 760192015593 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 760192015594 NAD(P) binding site [chemical binding]; other site 760192015595 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 760192015596 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 760192015597 AsnC family; Region: AsnC_trans_reg; pfam01037 760192015598 TraB family; Region: TraB; pfam01963 760192015599 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760192015600 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 760192015601 AP (apurinic/apyrimidinic) site pocket; other site 760192015602 DNA interaction; other site 760192015603 Metal-binding active site; metal-binding site 760192015604 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 760192015605 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760192015606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192015607 catalytic residue [active] 760192015608 PA14 domain; Region: PA14; cl08459 760192015609 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192015610 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192015611 ligand binding site [chemical binding]; other site 760192015612 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015613 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192015614 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192015615 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 760192015616 N-terminal plug; other site 760192015617 ligand-binding site [chemical binding]; other site 760192015618 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 760192015619 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192015620 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192015621 active site 760192015622 catalytic tetrad [active] 760192015623 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192015624 Sulfatase; Region: Sulfatase; cl17466 760192015625 CotH protein; Region: CotH; pfam08757 760192015626 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015627 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 760192015628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192015629 S-adenosylmethionine binding site [chemical binding]; other site 760192015630 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 760192015631 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 760192015632 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 760192015633 ligand binding site [chemical binding]; other site 760192015634 homodimer interface [polypeptide binding]; other site 760192015635 NAD(P) binding site [chemical binding]; other site 760192015636 trimer interface B [polypeptide binding]; other site 760192015637 trimer interface A [polypeptide binding]; other site 760192015638 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 760192015639 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 760192015640 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 760192015641 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 760192015642 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 760192015643 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 760192015644 dimer interface [polypeptide binding]; other site 760192015645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760192015646 catalytic residue [active] 760192015647 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 760192015648 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760192015649 LysM domain; Region: LysM; pfam01476 760192015650 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 760192015651 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 760192015652 Ligand binding site; other site 760192015653 oligomer interface; other site 760192015654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 760192015655 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 760192015656 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 760192015657 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 760192015658 active site 760192015659 catalytic motif [active] 760192015660 Zn binding site [ion binding]; other site 760192015661 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 760192015662 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 760192015663 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 760192015664 Multicopper oxidase; Region: Cu-oxidase; pfam00394 760192015665 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 760192015666 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 760192015667 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 760192015668 putative NAD(P) binding site [chemical binding]; other site 760192015669 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 760192015670 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192015671 FAD binding domain; Region: FAD_binding_4; pfam01565 760192015672 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 760192015673 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 760192015674 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 760192015675 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 760192015676 dimer interface [polypeptide binding]; other site 760192015677 active site 760192015678 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760192015679 catalytic residues [active] 760192015680 substrate binding site [chemical binding]; other site 760192015681 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 760192015682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192015683 S-adenosylmethionine binding site [chemical binding]; other site 760192015684 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 760192015685 exonuclease subunit SbcD; Provisional; Region: PRK10966 760192015686 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 760192015687 active site 760192015688 metal binding site [ion binding]; metal-binding site 760192015689 DNA binding site [nucleotide binding] 760192015690 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 760192015691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192015692 AAA domain; Region: AAA_23; pfam13476 760192015693 Walker A/P-loop; other site 760192015694 ATP binding site [chemical binding]; other site 760192015695 Q-loop/lid; other site 760192015696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192015697 ABC transporter signature motif; other site 760192015698 Walker B; other site 760192015699 D-loop; other site 760192015700 H-loop/switch region; other site 760192015701 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 760192015702 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 760192015703 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 760192015704 G1 box; other site 760192015705 putative GEF interaction site [polypeptide binding]; other site 760192015706 GTP/Mg2+ binding site [chemical binding]; other site 760192015707 Switch I region; other site 760192015708 G2 box; other site 760192015709 G3 box; other site 760192015710 Switch II region; other site 760192015711 G4 box; other site 760192015712 G5 box; other site 760192015713 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 760192015714 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 760192015715 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 760192015716 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015717 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 760192015718 active site 760192015719 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760192015720 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760192015721 RNA binding surface [nucleotide binding]; other site 760192015722 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760192015723 active site 760192015724 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 760192015725 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760192015726 putative active site [active] 760192015727 putative metal binding site [ion binding]; other site 760192015728 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 760192015729 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 760192015730 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 760192015731 active site 760192015732 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 760192015733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192015734 Walker A motif; other site 760192015735 ATP binding site [chemical binding]; other site 760192015736 Walker B motif; other site 760192015737 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 760192015738 stage V sporulation protein K; Region: spore_V_K; TIGR02881 760192015739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192015740 Walker A motif; other site 760192015741 ATP binding site [chemical binding]; other site 760192015742 Walker B motif; other site 760192015743 arginine finger; other site 760192015744 stage V sporulation protein K; Region: spore_V_K; TIGR02881 760192015745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192015746 Walker A motif; other site 760192015747 ATP binding site [chemical binding]; other site 760192015748 Walker B motif; other site 760192015749 arginine finger; other site 760192015750 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 760192015751 HEAT repeats; Region: HEAT_2; pfam13646 760192015752 HEAT repeats; Region: HEAT_2; pfam13646 760192015753 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 760192015754 Cytochrome c; Region: Cytochrom_C; pfam00034 760192015755 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 760192015756 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192015757 putative active site [active] 760192015758 putative NTP binding site [chemical binding]; other site 760192015759 putative nucleic acid binding site [nucleotide binding]; other site 760192015760 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 760192015761 Protease prsW family; Region: PrsW-protease; pfam13367 760192015762 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 760192015763 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 760192015764 active site 760192015765 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192015766 structural tetrad; other site 760192015767 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192015768 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192015769 structural tetrad; other site 760192015770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192015771 binding surface 760192015772 TPR motif; other site 760192015773 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 760192015774 SnoaL-like domain; Region: SnoaL_3; pfam13474 760192015775 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 760192015776 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 760192015777 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192015778 catalytic residue [active] 760192015779 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 760192015780 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 760192015781 dimer interface [polypeptide binding]; other site 760192015782 putative functional site; other site 760192015783 putative MPT binding site; other site 760192015784 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 760192015785 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 760192015786 trimerization site [polypeptide binding]; other site 760192015787 active site 760192015788 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 760192015789 Cysteine-rich domain; Region: CCG; pfam02754 760192015790 Cysteine-rich domain; Region: CCG; pfam02754 760192015791 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192015792 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192015793 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192015794 Sulfatase; Region: Sulfatase; cl17466 760192015795 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 760192015796 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015797 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 760192015798 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 760192015799 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 760192015800 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 760192015801 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760192015802 Zn2+ binding site [ion binding]; other site 760192015803 Mg2+ binding site [ion binding]; other site 760192015804 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015805 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015806 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 760192015807 Proline dehydrogenase; Region: Pro_dh; cl03282 760192015808 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 760192015809 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 760192015810 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 760192015811 shikimate binding site; other site 760192015812 NAD(P) binding site [chemical binding]; other site 760192015813 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 760192015814 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 760192015815 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 760192015816 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 760192015817 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 760192015818 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 760192015819 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 760192015820 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760192015821 Walker A/P-loop; other site 760192015822 ATP binding site [chemical binding]; other site 760192015823 Q-loop/lid; other site 760192015824 ABC transporter signature motif; other site 760192015825 Walker B; other site 760192015826 D-loop; other site 760192015827 H-loop/switch region; other site 760192015828 DoxX-like family; Region: DoxX_2; pfam13564 760192015829 Heme NO binding associated; Region: HNOBA; pfam07701 760192015830 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 760192015831 cyclase homology domain; Region: CHD; cd07302 760192015832 nucleotidyl binding site; other site 760192015833 metal binding site [ion binding]; metal-binding site 760192015834 dimer interface [polypeptide binding]; other site 760192015835 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 760192015836 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192015837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192015838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192015839 DNA binding residues [nucleotide binding] 760192015840 Uncharacterized conserved protein [Function unknown]; Region: COG3538 760192015841 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 760192015842 putative transporter; Provisional; Region: PRK10484 760192015843 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 760192015844 Na binding site [ion binding]; other site 760192015845 substrate binding site [chemical binding]; other site 760192015846 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192015847 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192015848 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192015849 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192015850 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 760192015851 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192015852 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192015853 ligand binding site [chemical binding]; other site 760192015854 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 760192015855 active site 760192015856 catalytic residues [active] 760192015857 metal binding site [ion binding]; metal-binding site 760192015858 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 760192015859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192015860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192015861 active site 760192015862 phosphorylation site [posttranslational modification] 760192015863 intermolecular recognition site; other site 760192015864 dimerization interface [polypeptide binding]; other site 760192015865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 760192015866 dimerization interface [polypeptide binding]; other site 760192015867 DNA binding residues [nucleotide binding] 760192015868 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 760192015869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192015870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192015871 ATP binding site [chemical binding]; other site 760192015872 Mg2+ binding site [ion binding]; other site 760192015873 G-X-G motif; other site 760192015874 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 760192015875 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 760192015876 nucleophile elbow; other site 760192015877 NAD-dependent deacetylase; Provisional; Region: PRK00481 760192015878 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 760192015879 NAD+ binding site [chemical binding]; other site 760192015880 substrate binding site [chemical binding]; other site 760192015881 Zn binding site [ion binding]; other site 760192015882 choline dehydrogenase; Validated; Region: PRK02106 760192015883 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192015884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192015885 AAA domain; Region: AAA_21; pfam13304 760192015886 Walker A/P-loop; other site 760192015887 ATP binding site [chemical binding]; other site 760192015888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 760192015889 Walker B; other site 760192015890 D-loop; other site 760192015891 H-loop/switch region; other site 760192015892 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760192015893 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 760192015894 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 760192015895 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 760192015896 active site 760192015897 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 760192015898 Peptidase family M23; Region: Peptidase_M23; pfam01551 760192015899 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 760192015900 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 760192015901 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 760192015902 mannose binding site [chemical binding]; other site 760192015903 dimerization interface [polypeptide binding]; other site 760192015904 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192015905 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192015906 putative active site [active] 760192015907 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 760192015908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 760192015909 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 760192015910 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192015911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192015912 Walker A motif; other site 760192015913 ATP binding site [chemical binding]; other site 760192015914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192015915 Walker A motif; other site 760192015916 ATP binding site [chemical binding]; other site 760192015917 Walker B motif; other site 760192015918 arginine finger; other site 760192015919 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 760192015920 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192015921 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192015922 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192015923 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192015924 CotH protein; Region: CotH; pfam08757 760192015925 CotH protein; Region: CotH; pfam08757 760192015926 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 760192015927 dimerization interface [polypeptide binding]; other site 760192015928 active site 760192015929 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760192015930 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 760192015931 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 760192015932 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 760192015933 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192015934 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 760192015935 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 760192015936 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 760192015937 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760192015938 protein binding site [polypeptide binding]; other site 760192015939 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 760192015940 Domain interface; other site 760192015941 Peptide binding site; other site 760192015942 Active site tetrad [active] 760192015943 Protein of unknown function (DUF433); Region: DUF433; pfam04255 760192015944 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 760192015945 ADP-ribose binding site [chemical binding]; other site 760192015946 Uncharacterized conserved protein [Function unknown]; Region: COG2442 760192015947 XisI protein; Region: XisI; pfam08869 760192015948 KWG Leptospira; Region: KWG; pfam07656 760192015949 DDE superfamily endonuclease; Region: DDE_5; cl17874 760192015950 Protein of unknown function (DUF416); Region: DUF416; cl01166 760192015951 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192015952 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192015953 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192015954 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760192015955 metal-dependent hydrolase; Provisional; Region: PRK13291 760192015956 DinB superfamily; Region: DinB_2; pfam12867 760192015957 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192015958 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192015959 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 760192015960 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 760192015961 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 760192015962 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192015963 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192015964 catalytic residues [active] 760192015965 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 760192015966 Putative esterase; Region: Esterase; pfam00756 760192015967 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192015968 Domain of unknown function (DUF303); Region: DUF303; pfam03629 760192015969 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 760192015970 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 760192015971 Putative esterase; Region: Esterase; pfam00756 760192015972 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192015973 Beta-lactamase; Region: Beta-lactamase; cl17358 760192015974 DoxX-like family; Region: DoxX_2; pfam13564 760192015975 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 760192015976 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192015977 ligand binding site [chemical binding]; other site 760192015978 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 760192015979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192015980 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 760192015981 YCII-related domain; Region: YCII; cl00999 760192015982 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 760192015983 putative active site [active] 760192015984 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 760192015985 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 760192015986 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 760192015987 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 760192015988 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192015989 putative catalytic residue [active] 760192015990 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 760192015991 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760192015992 catalytic residues [active] 760192015993 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 760192015994 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 760192015995 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 760192015996 TIR domain; Region: TIR_2; pfam13676 760192015997 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192015998 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192015999 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192016000 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192016001 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 760192016002 putative dimer interface [polypeptide binding]; other site 760192016003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760192016004 dimerization interface [polypeptide binding]; other site 760192016005 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 760192016006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 760192016007 putative active site [active] 760192016008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760192016009 dimer interface [polypeptide binding]; other site 760192016010 phosphorylation site [posttranslational modification] 760192016011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192016012 ATP binding site [chemical binding]; other site 760192016013 Mg2+ binding site [ion binding]; other site 760192016014 G-X-G motif; other site 760192016015 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 760192016016 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 760192016017 Ligand Binding Site [chemical binding]; other site 760192016018 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 760192016019 K+-transporting ATPase, c chain; Region: KdpC; cl00944 760192016020 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 760192016021 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760192016022 Soluble P-type ATPase [General function prediction only]; Region: COG4087 760192016023 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 760192016024 Uncharacterized conserved protein [Function unknown]; Region: COG1284 760192016025 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 760192016026 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 760192016027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192016028 active site 760192016029 phosphorylation site [posttranslational modification] 760192016030 intermolecular recognition site; other site 760192016031 dimerization interface [polypeptide binding]; other site 760192016032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192016033 Walker A motif; other site 760192016034 ATP binding site [chemical binding]; other site 760192016035 Walker B motif; other site 760192016036 arginine finger; other site 760192016037 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760192016038 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 760192016039 A new structural DNA glycosylase; Region: AlkD_like; cd06561 760192016040 active site 760192016041 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 760192016042 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 760192016043 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 760192016044 active site 760192016045 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 760192016046 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 760192016047 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 760192016048 tetramer interface [polypeptide binding]; other site 760192016049 TPP-binding site [chemical binding]; other site 760192016050 heterodimer interface [polypeptide binding]; other site 760192016051 phosphorylation loop region [posttranslational modification] 760192016052 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 760192016053 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 760192016054 PYR/PP interface [polypeptide binding]; other site 760192016055 dimer interface [polypeptide binding]; other site 760192016056 TPP binding site [chemical binding]; other site 760192016057 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 760192016058 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 760192016059 active site 760192016060 TIR domain; Region: TIR_2; pfam13676 760192016061 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016062 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016063 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 760192016064 Beta-lactamase; Region: Beta-lactamase; pfam00144 760192016065 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 760192016066 Zn binding site [ion binding]; other site 760192016067 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 760192016068 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 760192016069 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 760192016070 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 760192016071 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 760192016072 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 760192016073 putative acyl-acceptor binding pocket; other site 760192016074 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 760192016075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760192016076 catalytic residue [active] 760192016077 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 760192016078 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 760192016079 Heavy-metal-associated domain; Region: HMA; pfam00403 760192016080 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760192016081 Soluble P-type ATPase [General function prediction only]; Region: COG4087 760192016082 L-fucose transporter; Provisional; Region: PRK10133; cl17665 760192016083 glucose/galactose transporter; Region: gluP; TIGR01272 760192016084 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 760192016085 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 760192016086 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 760192016087 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 760192016088 iron-sulfur cluster [ion binding]; other site 760192016089 [2Fe-2S] cluster binding site [ion binding]; other site 760192016090 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 760192016091 active site 760192016092 dimer interface [polypeptide binding]; other site 760192016093 NifU-like domain; Region: NifU; cl00484 760192016094 Domain of unknown function DUF59; Region: DUF59; pfam01883 760192016095 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 760192016096 Walker A motif; other site 760192016097 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 760192016098 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 760192016099 active site 760192016100 Riboflavin kinase; Region: Flavokinase; pfam01687 760192016101 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 760192016102 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 760192016103 Probable Catalytic site; other site 760192016104 metal-binding site 760192016105 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760192016106 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760192016107 active site 760192016108 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 760192016109 XisI protein; Region: XisI; pfam08869 760192016110 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 760192016111 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 760192016112 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 760192016113 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 760192016114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760192016115 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 760192016116 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 760192016117 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 760192016118 dimer interface [polypeptide binding]; other site 760192016119 PYR/PP interface [polypeptide binding]; other site 760192016120 TPP binding site [chemical binding]; other site 760192016121 substrate binding site [chemical binding]; other site 760192016122 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 760192016123 Domain of unknown function; Region: EKR; pfam10371 760192016124 4Fe-4S binding domain; Region: Fer4_6; pfam12837 760192016125 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 760192016126 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 760192016127 TPP-binding site [chemical binding]; other site 760192016128 dimer interface [polypeptide binding]; other site 760192016129 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 760192016130 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 760192016131 folate binding site [chemical binding]; other site 760192016132 NADP+ binding site [chemical binding]; other site 760192016133 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 760192016134 isocitrate dehydrogenase; Validated; Region: PRK09222 760192016135 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 760192016136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 760192016137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760192016138 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 760192016139 dimerization interface [polypeptide binding]; other site 760192016140 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 760192016141 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760192016142 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 760192016143 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 760192016144 homodimer interface [polypeptide binding]; other site 760192016145 putative substrate binding pocket [chemical binding]; other site 760192016146 diiron center [ion binding]; other site 760192016147 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 760192016148 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192016149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192016150 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192016151 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 760192016152 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 760192016153 homodimer interface [polypeptide binding]; other site 760192016154 substrate-cofactor binding pocket; other site 760192016155 catalytic residue [active] 760192016156 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 760192016157 acetolactate synthase, small subunit; Region: acolac_sm; TIGR00119 760192016158 putative valine binding site [chemical binding]; other site 760192016159 dimer interface [polypeptide binding]; other site 760192016160 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 760192016161 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 760192016162 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 760192016163 PYR/PP interface [polypeptide binding]; other site 760192016164 dimer interface [polypeptide binding]; other site 760192016165 TPP binding site [chemical binding]; other site 760192016166 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 760192016167 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 760192016168 TPP-binding site [chemical binding]; other site 760192016169 dimer interface [polypeptide binding]; other site 760192016170 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 760192016171 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192016172 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 760192016173 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192016174 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 760192016175 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 760192016176 active site 760192016177 catalytic residues [active] 760192016178 transcription antitermination factor NusB; Region: nusB; TIGR01951 760192016179 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 760192016180 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 760192016181 ligand binding site [chemical binding]; other site 760192016182 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016183 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192016185 binding surface 760192016186 TPR motif; other site 760192016187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760192016188 Histidine kinase; Region: HisKA_3; pfam07730 760192016189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760192016190 ATP binding site [chemical binding]; other site 760192016191 Mg2+ binding site [ion binding]; other site 760192016192 G-X-G motif; other site 760192016193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760192016194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192016195 active site 760192016196 phosphorylation site [posttranslational modification] 760192016197 intermolecular recognition site; other site 760192016198 dimerization interface [polypeptide binding]; other site 760192016199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760192016200 DNA binding residues [nucleotide binding] 760192016201 dimerization interface [polypeptide binding]; other site 760192016202 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 760192016203 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 760192016204 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 760192016205 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192016206 protein binding site [polypeptide binding]; other site 760192016207 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 760192016208 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192016209 protein binding site [polypeptide binding]; other site 760192016210 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760192016211 protein binding site [polypeptide binding]; other site 760192016212 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192016213 TIR domain; Region: TIR_2; pfam13676 760192016214 CHAT domain; Region: CHAT; cl17868 760192016215 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016216 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 760192016217 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192016218 G1 box; other site 760192016219 GTP/Mg2+ binding site [chemical binding]; other site 760192016220 G2 box; other site 760192016221 Switch I region; other site 760192016222 G3 box; other site 760192016223 Switch II region; other site 760192016224 G4 box; other site 760192016225 G5 box; other site 760192016226 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016227 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016228 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016229 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016230 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016231 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 760192016232 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192016233 G1 box; other site 760192016234 GTP/Mg2+ binding site [chemical binding]; other site 760192016235 G2 box; other site 760192016236 Switch I region; other site 760192016237 G3 box; other site 760192016238 Switch II region; other site 760192016239 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016240 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016241 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016242 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016243 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016244 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016245 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016246 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016247 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016248 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192016249 G1 box; other site 760192016250 GTP/Mg2+ binding site [chemical binding]; other site 760192016251 G2 box; other site 760192016252 Switch I region; other site 760192016253 G3 box; other site 760192016254 Switch II region; other site 760192016255 G4 box; other site 760192016256 G5 box; other site 760192016257 TIR domain; Region: TIR_2; pfam13676 760192016258 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 760192016259 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 760192016260 active site 760192016261 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 760192016262 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 760192016263 active site 760192016264 trimer interface [polypeptide binding]; other site 760192016265 allosteric site; other site 760192016266 active site lid [active] 760192016267 hexamer (dimer of trimers) interface [polypeptide binding]; other site 760192016268 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 760192016269 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760192016270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760192016271 nucleotide binding site [chemical binding]; other site 760192016272 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760192016273 DNA binding site [nucleotide binding] 760192016274 domain linker motif; other site 760192016275 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 760192016276 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760192016277 ligand binding site [chemical binding]; other site 760192016278 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192016279 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192016280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 760192016281 DNA binding residues [nucleotide binding] 760192016282 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192016283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192016284 active site 760192016285 phosphorylation site [posttranslational modification] 760192016286 intermolecular recognition site; other site 760192016287 dimerization interface [polypeptide binding]; other site 760192016288 LytTr DNA-binding domain; Region: LytTR; smart00850 760192016289 Histidine kinase; Region: His_kinase; pfam06580 760192016290 ATP binding site [chemical binding]; other site 760192016291 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 760192016292 Mg2+ binding site [ion binding]; other site 760192016293 G-X-G motif; other site 760192016294 Histidine kinase; Region: His_kinase; pfam06580 760192016295 KilA-N domain; Region: KilA-N; pfam04383 760192016296 RmuC family; Region: RmuC; pfam02646 760192016297 Caspase domain; Region: Peptidase_C14; pfam00656 760192016298 AAA domain; Region: AAA_22; pfam13401 760192016299 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016300 structural tetrad; other site 760192016301 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016302 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192016303 structural tetrad; other site 760192016304 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016305 structural tetrad; other site 760192016306 Caspase domain; Region: Peptidase_C14; pfam00656 760192016307 NACHT domain; Region: NACHT; pfam05729 760192016308 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016309 structural tetrad; other site 760192016310 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192016311 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016312 structural tetrad; other site 760192016313 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016314 structural tetrad; other site 760192016315 Caspase domain; Region: Peptidase_C14; pfam00656 760192016316 NACHT domain; Region: NACHT; pfam05729 760192016317 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192016318 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016319 structural tetrad; other site 760192016320 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016321 structural tetrad; other site 760192016322 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016323 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016324 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016325 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016326 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016327 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016328 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016329 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016330 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192016331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192016332 Walker A motif; other site 760192016333 ATP binding site [chemical binding]; other site 760192016334 Walker B motif; other site 760192016335 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 760192016336 arginine finger; other site 760192016337 CHAT domain; Region: CHAT; cl17868 760192016338 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 760192016339 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760192016340 Catalytic site [active] 760192016341 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 760192016342 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 760192016343 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 760192016344 putative active site [active] 760192016345 putative NTP binding site [chemical binding]; other site 760192016346 putative nucleic acid binding site [nucleotide binding]; other site 760192016347 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 760192016348 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 760192016349 active site 760192016350 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 760192016351 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 760192016352 active site 760192016353 DNA binding site [nucleotide binding] 760192016354 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 760192016355 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 760192016356 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 760192016357 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 760192016358 active site 760192016359 NTP binding site [chemical binding]; other site 760192016360 metal binding triad [ion binding]; metal-binding site 760192016361 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760192016362 putative DNA binding site [nucleotide binding]; other site 760192016363 putative Zn2+ binding site [ion binding]; other site 760192016364 MerT mercuric transport protein; Region: MerT; cl03578 760192016365 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 760192016366 metal-binding site [ion binding] 760192016367 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192016368 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192016369 ligand binding site [chemical binding]; other site 760192016370 flexible hinge region; other site 760192016371 Helix-turn-helix domain; Region: HTH_18; pfam12833 760192016372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192016373 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 760192016374 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 760192016375 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 760192016376 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 760192016377 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 760192016378 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 760192016379 active site residue [active] 760192016380 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 760192016381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760192016382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760192016383 putative substrate translocation pore; other site 760192016384 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 760192016385 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 760192016386 BRO family, N-terminal domain; Region: Bro-N; smart01040 760192016387 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760192016388 S-adenosylmethionine binding site [chemical binding]; other site 760192016389 Methyltransferase domain; Region: Methyltransf_27; pfam13708 760192016390 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 760192016391 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 760192016392 chaperone protein DnaJ; Provisional; Region: PRK14279 760192016393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192016394 Virulence protein [General function prediction only]; Region: COG3943 760192016395 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 760192016396 CHAT domain; Region: CHAT; cl17868 760192016397 AAA ATPase domain; Region: AAA_16; pfam13191 760192016398 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016400 binding surface 760192016401 TPR motif; other site 760192016402 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016403 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016405 binding surface 760192016406 TPR motif; other site 760192016407 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016408 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016409 Tetratricopeptide repeat; Region: TPR_10; pfam13374 760192016410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 760192016412 binding surface 760192016413 TPR motif; other site 760192016414 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192016415 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 760192016416 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192016417 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192016418 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192016419 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192016420 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 760192016421 Outer membrane efflux protein; Region: OEP; pfam02321 760192016422 Outer membrane efflux protein; Region: OEP; pfam02321 760192016423 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192016424 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 760192016425 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192016426 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 760192016427 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760192016428 Soluble P-type ATPase [General function prediction only]; Region: COG4087 760192016429 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 760192016430 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 760192016431 iron-sulfur cluster [ion binding]; other site 760192016432 [2Fe-2S] cluster binding site [ion binding]; other site 760192016433 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 760192016434 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 760192016435 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 760192016436 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 760192016437 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 760192016438 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 760192016439 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 760192016440 Protein export membrane protein; Region: SecD_SecF; cl14618 760192016441 Outer membrane efflux protein; Region: OEP; pfam02321 760192016442 Outer membrane efflux protein; Region: OEP; pfam02321 760192016443 YtkA-like; Region: YtkA; pfam13115 760192016444 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192016445 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 760192016446 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192016447 Tubby C 2; Region: Tub_2; cl02043 760192016448 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 760192016449 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 760192016450 Outer membrane efflux protein; Region: OEP; pfam02321 760192016451 Outer membrane efflux protein; Region: OEP; pfam02321 760192016452 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 760192016453 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 760192016454 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192016455 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760192016456 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 760192016457 HlyD family secretion protein; Region: HlyD_3; pfam13437 760192016458 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 760192016459 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 760192016460 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 760192016461 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192016462 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 760192016463 active site 760192016464 FOG: PKD repeat [General function prediction only]; Region: COG3291 760192016465 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192016466 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 760192016467 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760192016468 Soluble P-type ATPase [General function prediction only]; Region: COG4087 760192016469 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192016470 Galactose oxidase, central domain; Region: Kelch_3; cl02701 760192016471 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 760192016472 KilA-N domain; Region: KilA-N; pfam04383 760192016473 CHC2 zinc finger; Region: zf-CHC2; cl17510 760192016474 Toprim-like; Region: Toprim_2; pfam13155 760192016475 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760192016476 Magnesium ion binding site [ion binding]; other site 760192016477 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 760192016478 Initiator Replication protein; Region: Rep_3; pfam01051 760192016479 KilA-N domain; Region: KilA-N; pfam04383 760192016480 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 760192016481 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 760192016482 active site 760192016483 catalytic residues [active] 760192016484 DNA binding site [nucleotide binding] 760192016485 Int/Topo IB signature motif; other site 760192016486 AAA ATPase domain; Region: AAA_16; pfam13191 760192016487 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760192016488 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 760192016489 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 760192016490 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 760192016491 active site 760192016492 catalytic triad [active] 760192016493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192016494 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192016495 Walker A motif; other site 760192016496 ATP binding site [chemical binding]; other site 760192016497 Walker B motif; other site 760192016498 arginine finger; other site 760192016499 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 760192016500 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 760192016501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192016502 ATP binding site [chemical binding]; other site 760192016503 putative Mg++ binding site [ion binding]; other site 760192016504 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 760192016505 nucleotide binding region [chemical binding]; other site 760192016506 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 760192016507 ATP-binding site [chemical binding]; other site 760192016508 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 760192016509 putative homodimer interface [polypeptide binding]; other site 760192016510 putative active site [active] 760192016511 catalytic site [active] 760192016512 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760192016513 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 760192016514 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 760192016515 HsdM N-terminal domain; Region: HsdM_N; pfam12161 760192016516 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 760192016517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760192016518 S-adenosylmethionine binding site [chemical binding]; other site 760192016519 Leucine rich repeat; Region: LRR_8; pfam13855 760192016520 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016521 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192016522 G1 box; other site 760192016523 GTP/Mg2+ binding site [chemical binding]; other site 760192016524 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 760192016525 G2 box; other site 760192016526 Switch I region; other site 760192016527 G3 box; other site 760192016528 Switch II region; other site 760192016529 G4 box; other site 760192016530 G5 box; other site 760192016531 KilA-N domain; Region: KilA-N; pfam04383 760192016532 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 760192016533 GTP/Mg2+ binding site [chemical binding]; other site 760192016534 G5 box; other site 760192016535 G1 box; other site 760192016536 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 760192016537 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192016538 WD domain, G-beta repeat; Region: WD40; pfam00400 760192016539 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016540 structural tetrad; other site 760192016541 WD40 repeats; Region: WD40; smart00320 760192016542 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 760192016543 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 760192016544 FOG: WD40 repeat [General function prediction only]; Region: COG2319 760192016545 structural tetrad; other site 760192016546 Septum formation initiator; Region: DivIC; cl17659 760192016547 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 760192016548 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 760192016549 nucleotide binding site [chemical binding]; other site 760192016550 putative NEF/HSP70 interaction site [polypeptide binding]; other site 760192016551 SBD interface [polypeptide binding]; other site 760192016552 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 760192016553 Catalytic domain of Protein Kinases; Region: PKc; cd00180 760192016554 active site 760192016555 ATP binding site [chemical binding]; other site 760192016556 substrate binding site [chemical binding]; other site 760192016557 activation loop (A-loop); other site 760192016558 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760192016559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192016560 Walker A motif; other site 760192016561 ATP binding site [chemical binding]; other site 760192016562 Walker B motif; other site 760192016563 arginine finger; other site 760192016564 Vps4 C terminal oligomerisation domain; Region: Vps4_C; pfam09336 760192016565 tellurium resistance terB-like protein; Region: terB_like; cd07177 760192016566 metal binding site [ion binding]; metal-binding site 760192016567 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 760192016568 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 760192016569 TIGR02687 family protein; Region: TIGR02687 760192016570 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 760192016571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 760192016572 Walker A motif; other site 760192016573 ATP binding site [chemical binding]; other site 760192016574 Walker B motif; other site 760192016575 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 760192016576 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760192016577 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 760192016578 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 760192016579 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 760192016580 G1 box; other site 760192016581 GTP/Mg2+ binding site [chemical binding]; other site 760192016582 G2 box; other site 760192016583 Switch I region; other site 760192016584 G3 box; other site 760192016585 Switch II region; other site 760192016586 G4 box; other site 760192016587 G5 box; other site 760192016588 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 760192016589 ADP-ribose binding site [chemical binding]; other site 760192016590 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192016591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192016592 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 760192016593 DNA binding residues [nucleotide binding] 760192016594 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192016595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192016596 active site 760192016597 phosphorylation site [posttranslational modification] 760192016598 intermolecular recognition site; other site 760192016599 dimerization interface [polypeptide binding]; other site 760192016600 LytTr DNA-binding domain; Region: LytTR; smart00850 760192016601 Histidine kinase; Region: His_kinase; pfam06580 760192016602 ATP binding site [chemical binding]; other site 760192016603 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 760192016604 Mg2+ binding site [ion binding]; other site 760192016605 G-X-G motif; other site 760192016606 Histidine kinase; Region: His_kinase; pfam06580 760192016607 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 760192016608 CHC2 zinc finger; Region: zf-CHC2; cl17510 760192016609 Toprim-like; Region: Toprim_2; pfam13155 760192016610 KilA-N domain; Region: KilA-N; pfam04383 760192016611 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016612 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016613 CHAT domain; Region: CHAT; cl17868 760192016614 NB-ARC domain; Region: NB-ARC; pfam00931 760192016615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016617 binding surface 760192016618 TPR motif; other site 760192016619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016620 binding surface 760192016621 TPR motif; other site 760192016622 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016623 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016625 binding surface 760192016626 TPR motif; other site 760192016627 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016630 binding surface 760192016631 TPR motif; other site 760192016632 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016634 AAA ATPase domain; Region: AAA_16; pfam13191 760192016635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016636 binding surface 760192016637 TPR motif; other site 760192016638 TPR repeat; Region: TPR_11; pfam13414 760192016639 TPR repeat; Region: TPR_11; pfam13414 760192016640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016641 binding surface 760192016642 Tetratricopeptide repeat; Region: TPR_16; pfam13432 760192016643 TPR motif; other site 760192016644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016645 binding surface 760192016646 TPR motif; other site 760192016647 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 760192016648 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760192016649 Catalytic site [active] 760192016650 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 760192016651 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 760192016652 active site 760192016653 DNA binding site [nucleotide binding] 760192016654 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 760192016655 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 760192016656 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 760192016657 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 760192016658 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 760192016659 putative active site [active] 760192016660 putative NTP binding site [chemical binding]; other site 760192016661 putative nucleic acid binding site [nucleotide binding]; other site 760192016662 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 760192016663 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 760192016664 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 760192016665 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 760192016666 CRISPR-associated protein; Region: DUF3692; pfam12469 760192016667 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 760192016668 SEC-C motif; Region: SEC-C; pfam02810 760192016669 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 760192016670 active site 760192016671 NTP binding site [chemical binding]; other site 760192016672 metal binding triad [ion binding]; metal-binding site 760192016673 BRO family, N-terminal domain; Region: Bro-N; smart01040 760192016674 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760192016675 S-adenosylmethionine binding site [chemical binding]; other site 760192016676 Methyltransferase domain; Region: Methyltransf_27; pfam13708 760192016677 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 760192016678 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 760192016679 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 760192016680 CHAT domain; Region: CHAT; cl17868 760192016681 Archaeal ATPase; Region: Arch_ATPase; pfam01637 760192016682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760192016683 Walker A motif; other site 760192016684 ATP binding site [chemical binding]; other site 760192016685 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016688 binding surface 760192016689 TPR motif; other site 760192016690 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016692 binding surface 760192016693 TPR motif; other site 760192016694 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016695 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016696 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016697 Tetratricopeptide repeat; Region: TPR_10; pfam13374 760192016698 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 760192016699 DEAD-like helicases superfamily; Region: DEXDc; smart00487 760192016700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760192016701 ATP binding site [chemical binding]; other site 760192016702 putative Mg++ binding site [ion binding]; other site 760192016703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192016704 ATP-binding site [chemical binding]; other site 760192016705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760192016706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760192016707 nucleotide binding region [chemical binding]; other site 760192016708 ATP-binding site [chemical binding]; other site 760192016709 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 760192016710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760192016711 AAA domain; Region: AAA_21; pfam13304 760192016712 Walker A/P-loop; other site 760192016713 ATP binding site [chemical binding]; other site 760192016714 AAA domain; Region: AAA_21; pfam13304 760192016715 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 760192016716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760192016717 Zn2+ binding site [ion binding]; other site 760192016718 Mg2+ binding site [ion binding]; other site 760192016719 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 760192016720 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016721 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016722 Caspase domain; Region: Peptidase_C14; pfam00656 760192016723 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016724 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016725 Caspase domain; Region: Peptidase_C14; pfam00656 760192016726 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016727 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016728 Caspase domain; Region: Peptidase_C14; pfam00656 760192016729 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016730 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016731 WGR domain; Region: WGR; cl01581 760192016732 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 760192016733 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 760192016734 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 760192016735 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760192016736 P-loop; other site 760192016737 Magnesium ion binding site [ion binding]; other site 760192016738 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760192016739 Magnesium ion binding site [ion binding]; other site 760192016740 AAA ATPase domain; Region: AAA_16; pfam13191 760192016741 Walker A motif; other site 760192016742 ATP binding site [chemical binding]; other site 760192016743 Walker B motif; other site 760192016744 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016746 binding surface 760192016747 TPR motif; other site 760192016748 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016749 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760192016751 binding surface 760192016752 TPR motif; other site 760192016753 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760192016754 BRO family, N-terminal domain; Region: Bro-N; cl10591 760192016755 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 760192016756 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 760192016757 active site 760192016758 catalytic residues [active] 760192016759 DNA binding site [nucleotide binding] 760192016760 Int/Topo IB signature motif; other site 760192016761 AAA ATPase domain; Region: AAA_16; pfam13191 760192016762 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 760192016763 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 760192016764 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192016765 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 760192016766 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192016767 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 760192016768 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 760192016769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760192016770 active site 760192016771 phosphorylation site [posttranslational modification] 760192016772 intermolecular recognition site; other site 760192016773 dimerization interface [polypeptide binding]; other site 760192016774 LytTr DNA-binding domain; Region: LytTR; smart00850 760192016775 Histidine kinase; Region: His_kinase; pfam06580 760192016776 Fic family protein [Function unknown]; Region: COG3177 760192016777 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 760192016778 Fic/DOC family; Region: Fic; pfam02661 760192016779 Uncharacterized conserved protein [Function unknown]; Region: COG1262 760192016780 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760192016781 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192016782 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 760192016783 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 760192016784 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 760192016785 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 760192016786 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 760192016787 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 760192016788 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192016789 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760192016790 DNA binding residues [nucleotide binding] 760192016791 FecR protein; Region: FecR; pfam04773 760192016792 Secretin and TonB N terminus short domain; Region: STN; pfam07660 760192016793 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192016794 Cna protein B-type domain; Region: Cna_B_2; pfam13715 760192016795 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192016796 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 760192016797 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192016798 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192016799 SusD family; Region: SusD; pfam07980 760192016800 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 760192016801 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 760192016802 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 760192016803 starch binding outer membrane protein SusD; Region: SusD; cl17845 760192016804 SusD family; Region: SusD; pfam07980 760192016805 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 760192016806 potential frameshift: common BLAST hit: gi|182415023|ref|YP_001820089.1| glycoside hydrolase family protein 760192016807 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 760192016808 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 760192016809 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 760192016810 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192016811 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192016812 Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718 760192016813 Melibiase; Region: Melibiase; pfam02065 760192016814 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 760192016815 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 760192016816 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 760192016817 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760192016818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192016819 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760192016820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192016821 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 760192016822 putative active site [active] 760192016823 catalytic site [active] 760192016824 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 760192016825 Domain of unknown function (DUF303); Region: DUF303; pfam03629 760192016826 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760192016827 Sulfatase; Region: Sulfatase; cl17466 760192016828 Transcriptional regulator [Transcription]; Region: IclR; COG1414 760192016829 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 760192016830 Bacterial transcriptional regulator; Region: IclR; pfam01614 760192016831 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 760192016832 starch binding outer membrane protein SusD; Region: SusD; cd08977 760192016833 SusD family; Region: SusD; pfam07980 760192016834 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760192016835 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760192016836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192016837 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760192016838 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760192016839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192016840 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 760192016841 classical (c) SDRs; Region: SDR_c; cd05233 760192016842 NAD(P) binding site [chemical binding]; other site 760192016843 active site 760192016844 hypothetical protein; Provisional; Region: PRK02947 760192016845 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 760192016846 putative active site [active] 760192016847 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 760192016848 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760192016849 active site 760192016850 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760192016851 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760192016852 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760192016853 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 760192016854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760192016855 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 760192016856 KilA-N domain; Region: KilA-N; pfam04383 760192016857 Initiator Replication protein; Region: Rep_3; pfam01051 760192016858 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 760192016859 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760192016860 P-loop; other site 760192016861 Magnesium ion binding site [ion binding]; other site 760192016862 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192016863 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192016864 ligand binding site [chemical binding]; other site 760192016865 flexible hinge region; other site 760192016866 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760192016867 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760192016868 ligand binding site [chemical binding]; other site 760192016869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192016870 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 760192016871 NAD(P) binding site [chemical binding]; other site 760192016872 active site 760192016873 NADH(P)-binding; Region: NAD_binding_10; pfam13460 760192016874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760192016875 NAD(P) binding site [chemical binding]; other site 760192016876 active site 760192016877 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 760192016878 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760192016879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760192016880 SnoaL-like domain; Region: SnoaL_2; pfam12680 760192016881 short chain dehydrogenase; Provisional; Region: PRK06180 760192016882 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 760192016883 NADP binding site [chemical binding]; other site 760192016884 active site 760192016885 steroid binding site; other site 760192016886 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760192016887 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760192016888 active site 760192016889 catalytic tetrad [active] 760192016890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760192016891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760192016892 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 760192016893 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 760192016894 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760192016895 substrate binding pocket [chemical binding]; other site 760192016896 Domain of unknown function (DUF897); Region: DUF897; cl01312 760192016897 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 760192016898 DDE superfamily endonuclease; Region: DDE_3; pfam13358 760192016899 Winged helix-turn helix; Region: HTH_29; pfam13551 760192016900 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760192016901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760192016902 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 760192016903 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 760192016904 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 760192016905 NADP binding site [chemical binding]; other site 760192016906 dimer interface [polypeptide binding]; other site 760192016907 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 760192016908 catalytic motif [active] 760192016909 Catalytic residue [active] 760192016910 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 760192016911 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 760192016912 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 760192016913 potential catalytic triad [active] 760192016914 conserved cys residue [active] 760192016915 Predicted transcriptional regulators [Transcription]; Region: COG1733 760192016916 HxlR-like helix-turn-helix; Region: HxlR; pfam01638