-- dump date   	20140619_110738
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
866895000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
866895000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
866895000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895000004	Walker A motif; other site
866895000005	ATP binding site [chemical binding]; other site
866895000006	Walker B motif; other site
866895000007	arginine finger; other site
866895000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
866895000009	DnaA box-binding interface [nucleotide binding]; other site
866895000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
866895000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
866895000012	putative DNA binding surface [nucleotide binding]; other site
866895000013	dimer interface [polypeptide binding]; other site
866895000014	beta-clamp/clamp loader binding surface; other site
866895000015	beta-clamp/translesion DNA polymerase binding surface; other site
866895000016	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
866895000017	recombination protein F; Reviewed; Region: recF; PRK00064
866895000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
866895000019	Walker A/P-loop; other site
866895000020	ATP binding site [chemical binding]; other site
866895000021	Q-loop/lid; other site
866895000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895000023	ABC transporter signature motif; other site
866895000024	Walker B; other site
866895000025	D-loop; other site
866895000026	H-loop/switch region; other site
866895000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
866895000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895000029	Mg2+ binding site [ion binding]; other site
866895000030	G-X-G motif; other site
866895000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
866895000032	anchoring element; other site
866895000033	dimer interface [polypeptide binding]; other site
866895000034	ATP binding site [chemical binding]; other site
866895000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
866895000036	active site
866895000037	putative metal-binding site [ion binding]; other site
866895000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
866895000039	DNA gyrase subunit A; Validated; Region: PRK05560
866895000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
866895000041	CAP-like domain; other site
866895000042	active site
866895000043	primary dimer interface [polypeptide binding]; other site
866895000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866895000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866895000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866895000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866895000048	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
866895000049	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866895000050	Zn2+ binding site [ion binding]; other site
866895000051	Mg2+ binding site [ion binding]; other site
866895000052	YaaC-like Protein; Region: YaaC; pfam14175
866895000053	YaaC-like Protein; Region: YaaC; pfam14175
866895000054	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
866895000055	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
866895000056	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
866895000057	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
866895000058	active site
866895000059	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
866895000060	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
866895000061	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
866895000062	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
866895000063	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
866895000064	active site
866895000065	multimer interface [polypeptide binding]; other site
866895000066	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
866895000067	Glutamine amidotransferase class-I; Region: GATase; pfam00117
866895000068	predicted active site [active]
866895000069	catalytic triad [active]
866895000070	seryl-tRNA synthetase; Provisional; Region: PRK05431
866895000071	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
866895000072	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
866895000073	dimer interface [polypeptide binding]; other site
866895000074	active site
866895000075	motif 1; other site
866895000076	motif 2; other site
866895000077	motif 3; other site
866895000078	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
866895000079	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
866895000080	Substrate-binding site [chemical binding]; other site
866895000081	Substrate specificity [chemical binding]; other site
866895000082	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
866895000083	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
866895000084	Substrate-binding site [chemical binding]; other site
866895000085	Substrate specificity [chemical binding]; other site
866895000086	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
866895000087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895000088	Walker A/P-loop; other site
866895000089	ATP binding site [chemical binding]; other site
866895000090	Q-loop/lid; other site
866895000091	ABC transporter signature motif; other site
866895000092	Walker B; other site
866895000093	D-loop; other site
866895000094	H-loop/switch region; other site
866895000095	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
866895000096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895000097	dimer interface [polypeptide binding]; other site
866895000098	conserved gate region; other site
866895000099	putative PBP binding loops; other site
866895000100	ABC-ATPase subunit interface; other site
866895000101	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
866895000102	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
866895000103	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
866895000104	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
866895000105	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866895000106	NAD binding site [chemical binding]; other site
866895000107	catalytic residues [active]
866895000108	substrate binding site [chemical binding]; other site
866895000109	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
866895000110	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
866895000111	acetyl-CoA synthetase; Provisional; Region: PRK04319
866895000112	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
866895000113	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
866895000114	active site
866895000115	acyl-activating enzyme (AAE) consensus motif; other site
866895000116	putative CoA binding site [chemical binding]; other site
866895000117	AMP binding site [chemical binding]; other site
866895000118	putative uracil/xanthine transporter; Provisional; Region: PRK11412
866895000119	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
866895000120	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895000121	intracellular protease, PfpI family; Region: PfpI; TIGR01382
866895000122	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
866895000123	proposed catalytic triad [active]
866895000124	conserved cys residue [active]
866895000125	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
866895000126	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
866895000127	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
866895000128	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895000129	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895000130	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
866895000131	active site
866895000132	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
866895000133	nucleoside/Zn binding site; other site
866895000134	dimer interface [polypeptide binding]; other site
866895000135	catalytic motif [active]
866895000136	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
866895000137	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895000138	Walker A motif; other site
866895000139	ATP binding site [chemical binding]; other site
866895000140	Walker B motif; other site
866895000141	arginine finger; other site
866895000142	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
866895000143	hypothetical protein; Validated; Region: PRK00153
866895000144	recombination protein RecR; Reviewed; Region: recR; PRK00076
866895000145	RecR protein; Region: RecR; pfam02132
866895000146	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
866895000147	putative active site [active]
866895000148	putative metal-binding site [ion binding]; other site
866895000149	tetramer interface [polypeptide binding]; other site
866895000150	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
866895000151	SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441
866895000152	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
866895000153	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
866895000154	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866895000155	catalytic residue [active]
866895000156	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
866895000157	thymidylate kinase; Validated; Region: tmk; PRK00698
866895000158	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
866895000159	TMP-binding site; other site
866895000160	ATP-binding site [chemical binding]; other site
866895000161	Protein of unknown function (DUF970); Region: DUF970; pfam06153
866895000162	Protein of unknown function (DUF327); Region: DUF327; pfam03885
866895000163	DNA polymerase III subunit delta'; Validated; Region: PRK08058
866895000164	DNA polymerase III subunit delta'; Validated; Region: PRK08485
866895000165	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
866895000166	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
866895000167	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
866895000168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895000169	S-adenosylmethionine binding site [chemical binding]; other site
866895000170	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
866895000171	GIY-YIG motif/motif A; other site
866895000172	putative active site [active]
866895000173	putative metal binding site [ion binding]; other site
866895000174	Predicted methyltransferases [General function prediction only]; Region: COG0313
866895000175	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
866895000176	putative SAM binding site [chemical binding]; other site
866895000177	putative homodimer interface [polypeptide binding]; other site
866895000178	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
866895000179	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
866895000180	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
866895000181	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
866895000182	active site
866895000183	HIGH motif; other site
866895000184	KMSKS motif; other site
866895000185	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
866895000186	tRNA binding surface [nucleotide binding]; other site
866895000187	anticodon binding site; other site
866895000188	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
866895000189	dimer interface [polypeptide binding]; other site
866895000190	putative tRNA-binding site [nucleotide binding]; other site
866895000191	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
866895000192	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
866895000193	active site
866895000194	3D domain; Region: 3D; cl01439
866895000195	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
866895000196	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
866895000197	putative active site [active]
866895000198	putative metal binding site [ion binding]; other site
866895000199	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
866895000200	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
866895000201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895000202	S-adenosylmethionine binding site [chemical binding]; other site
866895000203	YabG peptidase U57; Region: Peptidase_U57; pfam05582
866895000204	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
866895000205	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
866895000206	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
866895000207	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866895000208	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
866895000209	pur operon repressor; Provisional; Region: PRK09213
866895000210	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
866895000211	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895000212	active site
866895000213	regulatory protein SpoVG; Reviewed; Region: PRK13259
866895000214	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
866895000215	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
866895000216	Substrate binding site; other site
866895000217	Mg++ binding site; other site
866895000218	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
866895000219	active site
866895000220	substrate binding site [chemical binding]; other site
866895000221	CoA binding site [chemical binding]; other site
866895000222	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
866895000223	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
866895000224	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895000225	active site
866895000226	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
866895000227	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
866895000228	5S rRNA interface [nucleotide binding]; other site
866895000229	CTC domain interface [polypeptide binding]; other site
866895000230	L16 interface [polypeptide binding]; other site
866895000231	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
866895000232	putative active site [active]
866895000233	catalytic residue [active]
866895000234	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
866895000235	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
866895000236	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
866895000237	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895000238	ATP binding site [chemical binding]; other site
866895000239	putative Mg++ binding site [ion binding]; other site
866895000240	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895000241	nucleotide binding region [chemical binding]; other site
866895000242	ATP-binding site [chemical binding]; other site
866895000243	TRCF domain; Region: TRCF; pfam03461
866895000244	stage V sporulation protein T; Region: spore_V_T; TIGR02851
866895000245	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
866895000246	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866895000247	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
866895000248	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
866895000249	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
866895000250	putative SAM binding site [chemical binding]; other site
866895000251	putative homodimer interface [polypeptide binding]; other site
866895000252	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
866895000253	homodimer interface [polypeptide binding]; other site
866895000254	metal binding site [ion binding]; metal-binding site
866895000255	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
866895000256	homodimer interface [polypeptide binding]; other site
866895000257	active site
866895000258	putative chemical substrate binding site [chemical binding]; other site
866895000259	metal binding site [ion binding]; metal-binding site
866895000260	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866895000261	RNA binding surface [nucleotide binding]; other site
866895000262	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
866895000263	sporulation protein YabP; Region: spore_yabP; TIGR02892
866895000264	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801
866895000265	Septum formation initiator; Region: DivIC; pfam04977
866895000266	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
866895000267	hypothetical protein; Provisional; Region: PRK08582
866895000268	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
866895000269	RNA binding site [nucleotide binding]; other site
866895000270	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
866895000271	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895000272	inhibitor-cofactor binding pocket; inhibition site
866895000273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895000274	catalytic residue [active]
866895000275	stage II sporulation protein E; Region: spore_II_E; TIGR02865
866895000276	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
866895000277	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
866895000278	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
866895000279	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
866895000280	metal ion-dependent adhesion site (MIDAS); other site
866895000281	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
866895000282	active site
866895000283	ATP binding site [chemical binding]; other site
866895000284	substrate binding site [chemical binding]; other site
866895000285	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
866895000286	substrate binding site [chemical binding]; other site
866895000287	activation loop (A-loop); other site
866895000288	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
866895000289	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
866895000290	Ligand Binding Site [chemical binding]; other site
866895000291	TilS substrate C-terminal domain; Region: TilS_C; smart00977
866895000292	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
866895000293	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895000294	active site
866895000295	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
866895000296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895000297	Walker A motif; other site
866895000298	ATP binding site [chemical binding]; other site
866895000299	Walker B motif; other site
866895000300	arginine finger; other site
866895000301	Peptidase family M41; Region: Peptidase_M41; pfam01434
866895000302	pantothenate kinase; Reviewed; Region: PRK13318
866895000303	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
866895000304	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
866895000305	dimerization interface [polypeptide binding]; other site
866895000306	domain crossover interface; other site
866895000307	redox-dependent activation switch; other site
866895000308	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
866895000309	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
866895000310	dimer interface [polypeptide binding]; other site
866895000311	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895000312	catalytic residue [active]
866895000313	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
866895000314	dihydropteroate synthase; Region: DHPS; TIGR01496
866895000315	substrate binding pocket [chemical binding]; other site
866895000316	dimer interface [polypeptide binding]; other site
866895000317	inhibitor binding site; inhibition site
866895000318	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
866895000319	homooctamer interface [polypeptide binding]; other site
866895000320	active site
866895000321	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
866895000322	catalytic center binding site [active]
866895000323	ATP binding site [chemical binding]; other site
866895000324	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
866895000325	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
866895000326	dimer interface [polypeptide binding]; other site
866895000327	putative anticodon binding site; other site
866895000328	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
866895000329	motif 1; other site
866895000330	active site
866895000331	motif 2; other site
866895000332	motif 3; other site
866895000333	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
866895000334	MgtC family; Region: MgtC; pfam02308
866895000335	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
866895000336	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
866895000337	UvrB/uvrC motif; Region: UVR; pfam02151
866895000338	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
866895000339	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
866895000340	ADP binding site [chemical binding]; other site
866895000341	phosphagen binding site; other site
866895000342	substrate specificity loop; other site
866895000343	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
866895000344	Clp amino terminal domain; Region: Clp_N; pfam02861
866895000345	Clp amino terminal domain; Region: Clp_N; pfam02861
866895000346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895000347	Walker A motif; other site
866895000348	ATP binding site [chemical binding]; other site
866895000349	Walker B motif; other site
866895000350	arginine finger; other site
866895000351	UvrB/uvrC motif; Region: UVR; pfam02151
866895000352	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895000353	Walker A motif; other site
866895000354	ATP binding site [chemical binding]; other site
866895000355	Walker B motif; other site
866895000356	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866895000357	DNA repair protein RadA; Provisional; Region: PRK11823
866895000358	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
866895000359	Walker A motif/ATP binding site; other site
866895000360	ATP binding site [chemical binding]; other site
866895000361	Walker B motif; other site
866895000362	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
866895000363	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
866895000364	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
866895000365	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
866895000366	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
866895000367	putative active site [active]
866895000368	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
866895000369	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
866895000370	substrate binding site; other site
866895000371	dimer interface; other site
866895000372	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
866895000373	homotrimer interaction site [polypeptide binding]; other site
866895000374	zinc binding site [ion binding]; other site
866895000375	CDP-binding sites; other site
866895000376	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
866895000377	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
866895000378	active site
866895000379	HIGH motif; other site
866895000380	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
866895000381	active site
866895000382	KMSKS motif; other site
866895000383	serine O-acetyltransferase; Region: cysE; TIGR01172
866895000384	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
866895000385	trimer interface [polypeptide binding]; other site
866895000386	active site
866895000387	substrate binding site [chemical binding]; other site
866895000388	CoA binding site [chemical binding]; other site
866895000389	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
866895000390	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
866895000391	active site
866895000392	HIGH motif; other site
866895000393	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
866895000394	KMSKS motif; other site
866895000395	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
866895000396	tRNA binding surface [nucleotide binding]; other site
866895000397	anticodon binding site; other site
866895000398	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
866895000399	active site
866895000400	metal binding site [ion binding]; metal-binding site
866895000401	dimerization interface [polypeptide binding]; other site
866895000402	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
866895000403	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
866895000404	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866895000405	YacP-like NYN domain; Region: NYN_YacP; pfam05991
866895000406	RNA polymerase factor sigma-70; Validated; Region: PRK08295
866895000407	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895000408	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
866895000409	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
866895000410	preprotein translocase, SecE subunit, bacterial; Region: secE_bact; TIGR00964
866895000411	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
866895000412	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
866895000413	putative homodimer interface [polypeptide binding]; other site
866895000414	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
866895000415	heterodimer interface [polypeptide binding]; other site
866895000416	homodimer interface [polypeptide binding]; other site
866895000417	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
866895000418	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
866895000419	23S rRNA interface [nucleotide binding]; other site
866895000420	L7/L12 interface [polypeptide binding]; other site
866895000421	putative thiostrepton binding site; other site
866895000422	L25 interface [polypeptide binding]; other site
866895000423	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
866895000424	mRNA/rRNA interface [nucleotide binding]; other site
866895000425	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
866895000426	23S rRNA interface [nucleotide binding]; other site
866895000427	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
866895000428	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
866895000429	core dimer interface [polypeptide binding]; other site
866895000430	peripheral dimer interface [polypeptide binding]; other site
866895000431	L10 interface [polypeptide binding]; other site
866895000432	L11 interface [polypeptide binding]; other site
866895000433	putative EF-Tu interaction site [polypeptide binding]; other site
866895000434	putative EF-G interaction site [polypeptide binding]; other site
866895000435	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
866895000436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895000437	S-adenosylmethionine binding site [chemical binding]; other site
866895000438	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
866895000439	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
866895000440	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
866895000441	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
866895000442	RPB1 interaction site [polypeptide binding]; other site
866895000443	RPB10 interaction site [polypeptide binding]; other site
866895000444	RPB11 interaction site [polypeptide binding]; other site
866895000445	RPB3 interaction site [polypeptide binding]; other site
866895000446	RPB12 interaction site [polypeptide binding]; other site
866895000447	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
866895000448	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
866895000449	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
866895000450	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
866895000451	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
866895000452	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
866895000453	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
866895000454	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
866895000455	DNA binding site [nucleotide binding]
866895000456	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
866895000457	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
866895000458	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
866895000459	S17 interaction site [polypeptide binding]; other site
866895000460	S8 interaction site; other site
866895000461	16S rRNA interaction site [nucleotide binding]; other site
866895000462	streptomycin interaction site [chemical binding]; other site
866895000463	23S rRNA interaction site [nucleotide binding]; other site
866895000464	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
866895000465	30S ribosomal protein S7; Validated; Region: PRK05302
866895000466	elongation factor G; Reviewed; Region: PRK00007
866895000467	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
866895000468	G1 box; other site
866895000469	putative GEF interaction site [polypeptide binding]; other site
866895000470	GTP/Mg2+ binding site [chemical binding]; other site
866895000471	Switch I region; other site
866895000472	G2 box; other site
866895000473	G3 box; other site
866895000474	Switch II region; other site
866895000475	G4 box; other site
866895000476	G5 box; other site
866895000477	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
866895000478	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
866895000479	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
866895000480	elongation factor Tu; Reviewed; Region: PRK00049
866895000481	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
866895000482	G1 box; other site
866895000483	GEF interaction site [polypeptide binding]; other site
866895000484	GTP/Mg2+ binding site [chemical binding]; other site
866895000485	Switch I region; other site
866895000486	G2 box; other site
866895000487	G3 box; other site
866895000488	Switch II region; other site
866895000489	G4 box; other site
866895000490	G5 box; other site
866895000491	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
866895000492	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
866895000493	Antibiotic Binding Site [chemical binding]; other site
866895000494	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
866895000495	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
866895000496	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
866895000497	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
866895000498	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
866895000499	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
866895000500	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
866895000501	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
866895000502	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
866895000503	putative translocon binding site; other site
866895000504	protein-rRNA interface [nucleotide binding]; other site
866895000505	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
866895000506	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
866895000507	G-X-X-G motif; other site
866895000508	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
866895000509	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
866895000510	23S rRNA interface [nucleotide binding]; other site
866895000511	5S rRNA interface [nucleotide binding]; other site
866895000512	putative antibiotic binding site [chemical binding]; other site
866895000513	L25 interface [polypeptide binding]; other site
866895000514	L27 interface [polypeptide binding]; other site
866895000515	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
866895000516	23S rRNA interface [nucleotide binding]; other site
866895000517	putative translocon interaction site; other site
866895000518	signal recognition particle (SRP54) interaction site; other site
866895000519	L23 interface [polypeptide binding]; other site
866895000520	trigger factor interaction site; other site
866895000521	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
866895000522	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
866895000523	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
866895000524	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
866895000525	RNA binding site [nucleotide binding]; other site
866895000526	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
866895000527	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
866895000528	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
866895000529	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
866895000530	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
866895000531	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
866895000532	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
866895000533	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
866895000534	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
866895000535	5S rRNA interface [nucleotide binding]; other site
866895000536	L27 interface [polypeptide binding]; other site
866895000537	23S rRNA interface [nucleotide binding]; other site
866895000538	L5 interface [polypeptide binding]; other site
866895000539	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
866895000540	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
866895000541	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
866895000542	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
866895000543	23S rRNA binding site [nucleotide binding]; other site
866895000544	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
866895000545	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
866895000546	SecY translocase; Region: SecY; pfam00344
866895000547	adenylate kinase; Reviewed; Region: adk; PRK00279
866895000548	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
866895000549	AMP-binding site [chemical binding]; other site
866895000550	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
866895000551	methionine aminopeptidase; Provisional; Region: PRK08671
866895000552	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
866895000553	active site
866895000554	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
866895000555	RNA binding site [nucleotide binding]; other site
866895000556	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
866895000557	rRNA binding site [nucleotide binding]; other site
866895000558	predicted 30S ribosome binding site; other site
866895000559	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
866895000560	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
866895000561	30S ribosomal protein S13; Region: bact_S13; TIGR03631
866895000562	30S ribosomal protein S11; Validated; Region: PRK05309
866895000563	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
866895000564	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
866895000565	alphaNTD homodimer interface [polypeptide binding]; other site
866895000566	alphaNTD - beta interaction site [polypeptide binding]; other site
866895000567	alphaNTD - beta' interaction site [polypeptide binding]; other site
866895000568	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
866895000569	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
866895000570	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
866895000571	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866895000572	Walker A/P-loop; other site
866895000573	ATP binding site [chemical binding]; other site
866895000574	Q-loop/lid; other site
866895000575	ABC transporter signature motif; other site
866895000576	Walker B; other site
866895000577	D-loop; other site
866895000578	H-loop/switch region; other site
866895000579	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
866895000580	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866895000581	Walker A/P-loop; other site
866895000582	ATP binding site [chemical binding]; other site
866895000583	Q-loop/lid; other site
866895000584	ABC transporter signature motif; other site
866895000585	Walker B; other site
866895000586	D-loop; other site
866895000587	H-loop/switch region; other site
866895000588	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
866895000589	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
866895000590	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
866895000591	dimerization interface 3.5A [polypeptide binding]; other site
866895000592	active site
866895000593	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
866895000594	23S rRNA interface [nucleotide binding]; other site
866895000595	L3 interface [polypeptide binding]; other site
866895000596	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
866895000597	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
866895000598	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
866895000599	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
866895000600	active site
866895000601	metal binding site [ion binding]; metal-binding site
866895000602	Domain of unknown function DUF59; Region: DUF59; cl00941
866895000603	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
866895000604	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
866895000605	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
866895000606	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
866895000607	Arginase family; Region: Arginase; cd09989
866895000608	agmatinase; Region: agmatinase; TIGR01230
866895000609	active site
866895000610	Mn binding site [ion binding]; other site
866895000611	oligomer interface [polypeptide binding]; other site
866895000612	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
866895000613	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
866895000614	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895000615	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895000616	DNA binding residues [nucleotide binding]
866895000617	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
866895000618	Putative zinc-finger; Region: zf-HC2; pfam13490
866895000619	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
866895000620	Uncharacterized conserved protein [Function unknown]; Region: COG1624
866895000621	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
866895000622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
866895000623	YbbR-like protein; Region: YbbR; pfam07949
866895000624	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
866895000625	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
866895000626	active site
866895000627	substrate binding site [chemical binding]; other site
866895000628	metal binding site [ion binding]; metal-binding site
866895000629	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
866895000630	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
866895000631	glutaminase active site [active]
866895000632	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
866895000633	dimer interface [polypeptide binding]; other site
866895000634	active site
866895000635	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
866895000636	dimer interface [polypeptide binding]; other site
866895000637	active site
866895000638	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
866895000639	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895000640	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895000641	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
866895000642	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
866895000643	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
866895000644	active site
866895000645	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
866895000646	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895000647	DNA-binding site [nucleotide binding]; DNA binding site
866895000648	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
866895000649	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
866895000650	Predicted membrane protein [Function unknown]; Region: COG2246
866895000651	GtrA-like protein; Region: GtrA; pfam04138
866895000652	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
866895000653	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
866895000654	Ligand binding site; other site
866895000655	Putative Catalytic site; other site
866895000656	DXD motif; other site
866895000657	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
866895000658	Putative esterase; Region: Esterase; pfam00756
866895000659	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
866895000660	nudix motif; other site
866895000661	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866895000662	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895000663	Coenzyme A binding pocket [chemical binding]; other site
866895000664	topology modulation protein; Reviewed; Region: PRK08118
866895000665	AAA domain; Region: AAA_17; pfam13207
866895000666	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
866895000667	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895000668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895000669	Walker A/P-loop; other site
866895000670	ATP binding site [chemical binding]; other site
866895000671	Q-loop/lid; other site
866895000672	ABC transporter signature motif; other site
866895000673	Walker B; other site
866895000674	D-loop; other site
866895000675	H-loop/switch region; other site
866895000676	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
866895000677	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895000678	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
866895000679	Walker A/P-loop; other site
866895000680	ATP binding site [chemical binding]; other site
866895000681	Q-loop/lid; other site
866895000682	ABC transporter signature motif; other site
866895000683	Walker B; other site
866895000684	D-loop; other site
866895000685	H-loop/switch region; other site
866895000686	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866895000687	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
866895000688	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895000689	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895000690	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
866895000691	dimer interface [polypeptide binding]; other site
866895000692	substrate binding site [chemical binding]; other site
866895000693	metal binding site [ion binding]; metal-binding site
866895000694	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
866895000695	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
866895000696	potential catalytic triad [active]
866895000697	conserved cys residue [active]
866895000698	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895000699	dimerization interface [polypeptide binding]; other site
866895000700	putative DNA binding site [nucleotide binding]; other site
866895000701	putative Zn2+ binding site [ion binding]; other site
866895000702	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
866895000703	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866895000704	Soluble P-type ATPase [General function prediction only]; Region: COG4087
866895000705	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
866895000706	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866895000707	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895000708	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866895000709	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
866895000710	HD domain; Region: HD_4; pfam13328
866895000711	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
866895000712	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
866895000713	active site
866895000714	Riboflavin kinase; Region: Flavokinase; pfam01687
866895000715	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
866895000716	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
866895000717	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
866895000718	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866895000719	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
866895000720	Helix-turn-helix domain; Region: HTH_28; pfam13518
866895000721	putative transposase OrfB; Reviewed; Region: PHA02517
866895000722	HTH-like domain; Region: HTH_21; pfam13276
866895000723	Integrase core domain; Region: rve; pfam00665
866895000724	Integrase core domain; Region: rve_2; pfam13333
866895000725	Uncharacterized conserved protein [Function unknown]; Region: COG1912
866895000726	Domain of unknown function (DUF4362); Region: DUF4362; pfam14275
866895000727	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895000728	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895000729	active site
866895000730	catalytic tetrad [active]
866895000731	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
866895000732	Subunit I/III interface [polypeptide binding]; other site
866895000733	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
866895000734	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866895000735	dimer interface [polypeptide binding]; other site
866895000736	putative CheW interface [polypeptide binding]; other site
866895000737	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
866895000738	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
866895000739	nucleoside/Zn binding site; other site
866895000740	dimer interface [polypeptide binding]; other site
866895000741	catalytic motif [active]
866895000742	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
866895000743	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
866895000744	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895000745	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
866895000746	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
866895000747	amino acid carrier protein; Region: agcS; TIGR00835
866895000748	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
866895000749	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
866895000750	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
866895000751	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
866895000752	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
866895000753	PYR/PP interface [polypeptide binding]; other site
866895000754	dimer interface [polypeptide binding]; other site
866895000755	TPP binding site [chemical binding]; other site
866895000756	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866895000757	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
866895000758	TPP-binding site [chemical binding]; other site
866895000759	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
866895000760	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
866895000761	GAF domain; Region: GAF; cl17456
866895000762	GAF domain; Region: GAF_2; pfam13185
866895000763	PAS domain S-box; Region: sensory_box; TIGR00229
866895000764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895000765	putative active site [active]
866895000766	heme pocket [chemical binding]; other site
866895000767	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866895000768	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866895000769	metal binding site [ion binding]; metal-binding site
866895000770	active site
866895000771	I-site; other site
866895000772	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866895000773	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
866895000774	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
866895000775	putative active site [active]
866895000776	putative NTP binding site [chemical binding]; other site
866895000777	putative nucleic acid binding site [nucleotide binding]; other site
866895000778	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
866895000779	active site
866895000780	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
866895000781	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
866895000782	intersubunit interface [polypeptide binding]; other site
866895000783	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866895000784	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866895000785	ABC-ATPase subunit  interface; other site
866895000786	dimer interface [polypeptide binding]; other site
866895000787	putative PBP binding regions; other site
866895000788	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
866895000789	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866895000790	ABC-ATPase subunit  interface; other site
866895000791	dimer interface [polypeptide binding]; other site
866895000792	putative PBP binding regions; other site
866895000793	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
866895000794	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895000795	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895000796	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
866895000797	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
866895000798	Glutaminase; Region: Glutaminase; cl00907
866895000799	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
866895000800	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
866895000801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895000802	Methyltransferase domain; Region: Methyltransf_31; pfam13847
866895000803	S-adenosylmethionine binding site [chemical binding]; other site
866895000804	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
866895000805	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866895000806	active site
866895000807	HIGH motif; other site
866895000808	nucleotide binding site [chemical binding]; other site
866895000809	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
866895000810	active site
866895000811	KMSKS motif; other site
866895000812	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
866895000813	tRNA binding surface [nucleotide binding]; other site
866895000814	anticodon binding site; other site
866895000815	PAS domain; Region: PAS_9; pfam13426
866895000816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895000817	putative active site [active]
866895000818	heme pocket [chemical binding]; other site
866895000819	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
866895000820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895000821	Walker A motif; other site
866895000822	ATP binding site [chemical binding]; other site
866895000823	Walker B motif; other site
866895000824	arginine finger; other site
866895000825	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
866895000826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
866895000827	Nucleoside recognition; Region: Gate; pfam07670
866895000828	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
866895000829	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895000830	inhibitor-cofactor binding pocket; inhibition site
866895000831	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895000832	catalytic residue [active]
866895000833	Protein of unknown function, DUF606; Region: DUF606; pfam04657
866895000834	quinolinate synthetase; Provisional; Region: PRK09375
866895000835	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
866895000836	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
866895000837	dimerization interface [polypeptide binding]; other site
866895000838	active site
866895000839	L-aspartate oxidase; Provisional; Region: PRK08071
866895000840	L-aspartate oxidase; Provisional; Region: PRK06175
866895000841	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
866895000842	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
866895000843	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
866895000844	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866895000845	catalytic residue [active]
866895000846	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
866895000847	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
866895000848	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
866895000849	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
866895000850	Walker A/P-loop; other site
866895000851	ATP binding site [chemical binding]; other site
866895000852	Q-loop/lid; other site
866895000853	ABC transporter signature motif; other site
866895000854	Walker B; other site
866895000855	D-loop; other site
866895000856	H-loop/switch region; other site
866895000857	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
866895000858	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
866895000859	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
866895000860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895000861	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895000862	putative substrate translocation pore; other site
866895000863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895000864	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
866895000865	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
866895000866	Virulence factor; Region: Virulence_fact; pfam13769
866895000867	HEAT repeats; Region: HEAT_2; pfam13646
866895000868	HEAT repeat; Region: HEAT; pfam02985
866895000869	HEAT repeats; Region: HEAT_2; pfam13646
866895000870	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
866895000871	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866895000872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895000873	Walker A/P-loop; other site
866895000874	ATP binding site [chemical binding]; other site
866895000875	Q-loop/lid; other site
866895000876	ABC transporter signature motif; other site
866895000877	Walker B; other site
866895000878	D-loop; other site
866895000879	H-loop/switch region; other site
866895000880	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
866895000881	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
866895000882	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
866895000883	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
866895000884	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
866895000885	active site pocket [active]
866895000886	oxyanion hole [active]
866895000887	catalytic triad [active]
866895000888	active site nucleophile [active]
866895000889	DinB superfamily; Region: DinB_2; pfam12867
866895000890	DinB family; Region: DinB; cl17821
866895000891	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
866895000892	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
866895000893	DNA binding residues [nucleotide binding]
866895000894	dimer interface [polypeptide binding]; other site
866895000895	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
866895000896	potential frameshift: common BLAST hit: gi|284045934|ref|YP_003396274.1| methyltransferase type 11
866895000897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895000898	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895000899	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895000900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
866895000901	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895000902	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
866895000903	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895000904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
866895000905	Predicted flavoprotein [General function prediction only]; Region: COG0431
866895000906	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866895000907	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866895000908	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866895000909	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
866895000910	classical (c) SDRs; Region: SDR_c; cd05233
866895000911	NAD(P) binding site [chemical binding]; other site
866895000912	active site
866895000913	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
866895000914	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866895000915	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
866895000916	EamA-like transporter family; Region: EamA; pfam00892
866895000917	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
866895000918	EamA-like transporter family; Region: EamA; pfam00892
866895000919	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
866895000920	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895000921	Coenzyme A binding pocket [chemical binding]; other site
866895000922	Predicted membrane protein [Function unknown]; Region: COG2855
866895000923	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866895000924	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866895000925	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
866895000926	putative dimerization interface [polypeptide binding]; other site
866895000927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895000928	putative substrate translocation pore; other site
866895000929	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866895000930	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866895000931	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866895000932	dimerization interface [polypeptide binding]; other site
866895000933	Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435
866895000934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895000935	PAS domain; Region: PAS_9; pfam13426
866895000936	putative active site [active]
866895000937	heme pocket [chemical binding]; other site
866895000938	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895000939	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
866895000940	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
866895000941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866895000942	Helix-turn-helix domain; Region: HTH_28; pfam13518
866895000943	putative transposase OrfB; Reviewed; Region: PHA02517
866895000944	HTH-like domain; Region: HTH_21; pfam13276
866895000945	Integrase core domain; Region: rve; pfam00665
866895000946	Integrase core domain; Region: rve_2; pfam13333
866895000947	intracellular protease, PfpI family; Region: PfpI; TIGR01382
866895000948	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
866895000949	proposed catalytic triad [active]
866895000950	conserved cys residue [active]
866895000951	Predicted membrane protein [Function unknown]; Region: COG4270
866895000952	Predicted secreted protein [Function unknown]; Region: COG4086
866895000953	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
866895000954	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866895000955	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
866895000956	nucleophilic elbow; other site
866895000957	catalytic triad; other site
866895000958	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
866895000959	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
866895000960	Cu(I) binding site [ion binding]; other site
866895000961	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866895000962	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
866895000963	potential frameshift: common BLAST hit: gi|218905896|ref|YP_002453730.1| prolyl aminopeptidase
866895000964	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
866895000965	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866895000966	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
866895000967	nudix motif; other site
866895000968	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
866895000969	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866895000970	homodimer interface [polypeptide binding]; other site
866895000971	substrate-cofactor binding pocket; other site
866895000972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895000973	catalytic residue [active]
866895000974	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866895000975	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
866895000976	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
866895000977	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895000978	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895000979	DNA binding residues [nucleotide binding]
866895000980	Putative zinc-finger; Region: zf-HC2; pfam13490
866895000981	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895000982	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895000983	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
866895000984	Cytochrome P450; Region: p450; pfam00067
866895000985	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
866895000986	Flavodoxin; Region: Flavodoxin_1; pfam00258
866895000987	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
866895000988	FAD binding pocket [chemical binding]; other site
866895000989	FAD binding motif [chemical binding]; other site
866895000990	catalytic residues [active]
866895000991	NAD binding pocket [chemical binding]; other site
866895000992	phosphate binding motif [ion binding]; other site
866895000993	beta-alpha-beta structure motif; other site
866895000994	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
866895000995	phytoene desaturase; Region: crtI_fam; TIGR02734
866895000996	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895000997	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
866895000998	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
866895000999	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
866895001000	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
866895001001	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
866895001002	active site
866895001003	Fe-S cluster binding site [ion binding]; other site
866895001004	YndJ-like protein; Region: YndJ; pfam14158
866895001005	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
866895001006	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
866895001007	dimer interface [polypeptide binding]; other site
866895001008	putative radical transfer pathway; other site
866895001009	diiron center [ion binding]; other site
866895001010	tyrosyl radical; other site
866895001011	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
866895001012	Class I ribonucleotide reductase; Region: RNR_I; cd01679
866895001013	active site
866895001014	dimer interface [polypeptide binding]; other site
866895001015	catalytic residues [active]
866895001016	effector binding site; other site
866895001017	R2 peptide binding site; other site
866895001018	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866895001019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895001020	S-adenosylmethionine binding site [chemical binding]; other site
866895001021	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
866895001022	PGAP1-like protein; Region: PGAP1; pfam07819
866895001023	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
866895001024	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
866895001025	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
866895001026	Predicted membrane protein [Function unknown]; Region: COG4325
866895001027	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
866895001028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895001029	Coenzyme A binding pocket [chemical binding]; other site
866895001030	NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151
866895001031	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866895001032	NAD(P) binding site [chemical binding]; other site
866895001033	catalytic residues [active]
866895001034	transaminase; Reviewed; Region: PRK08068
866895001035	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866895001036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895001037	homodimer interface [polypeptide binding]; other site
866895001038	catalytic residue [active]
866895001039	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
866895001040	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895001041	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895001042	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866895001043	Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575
866895001044	active site
866895001045	dimer interface [polypeptide binding]; other site
866895001046	Predicted amidohydrolase [General function prediction only]; Region: COG0388
866895001047	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
866895001048	putative active site [active]
866895001049	catalytic triad [active]
866895001050	putative dimer interface [polypeptide binding]; other site
866895001051	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
866895001052	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
866895001053	Histidine kinase; Region: His_kinase; pfam06580
866895001054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895001055	ATP binding site [chemical binding]; other site
866895001056	Mg2+ binding site [ion binding]; other site
866895001057	G-X-G motif; other site
866895001058	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
866895001059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895001060	active site
866895001061	phosphorylation site [posttranslational modification]
866895001062	intermolecular recognition site; other site
866895001063	dimerization interface [polypeptide binding]; other site
866895001064	LytTr DNA-binding domain; Region: LytTR; smart00850
866895001065	Carbon starvation protein CstA; Region: CstA; pfam02554
866895001066	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
866895001067	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
866895001068	Carbon starvation protein CstA; Region: CstA; pfam02554
866895001069	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
866895001070	Predicted acetyltransferase [General function prediction only]; Region: COG2388
866895001071	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
866895001072	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
866895001073	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
866895001074	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866895001075	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866895001076	catalytic residue [active]
866895001077	Predicted flavoprotein [General function prediction only]; Region: COG0431
866895001078	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866895001079	Uncharacterized conserved protein [Function unknown]; Region: COG3339
866895001080	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
866895001081	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
866895001082	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
866895001083	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895001084	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895001085	Probable transposase; Region: OrfB_IS605; pfam01385
866895001086	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895001087	BCCT family transporter; Region: BCCT; pfam02028
866895001088	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866895001089	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866895001090	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
866895001091	Predicted membrane protein [Function unknown]; Region: COG4325
866895001092	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
866895001093	BCCT family transporter; Region: BCCT; pfam02028
866895001094	Domain of unknown function (DUF368); Region: DUF368; pfam04018
866895001095	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866895001096	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866895001097	catalytic residues [active]
866895001098	Transposase; Region: HTH_Tnp_1; cl17663
866895001099	putative transposase OrfB; Reviewed; Region: PHA02517
866895001100	HTH-like domain; Region: HTH_21; pfam13276
866895001101	Integrase core domain; Region: rve; pfam00665
866895001102	Integrase core domain; Region: rve_3; pfam13683
866895001103	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
866895001104	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895001105	Uncharacterized conserved protein [Function unknown]; Region: COG0398
866895001106	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
866895001107	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
866895001108	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
866895001109	Walker A/P-loop; other site
866895001110	ATP binding site [chemical binding]; other site
866895001111	Q-loop/lid; other site
866895001112	ABC transporter signature motif; other site
866895001113	Walker B; other site
866895001114	D-loop; other site
866895001115	H-loop/switch region; other site
866895001116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895001117	dimer interface [polypeptide binding]; other site
866895001118	conserved gate region; other site
866895001119	putative PBP binding loops; other site
866895001120	ABC-ATPase subunit interface; other site
866895001121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895001122	dimer interface [polypeptide binding]; other site
866895001123	conserved gate region; other site
866895001124	putative PBP binding loops; other site
866895001125	ABC-ATPase subunit interface; other site
866895001126	hypothetical protein; Provisional; Region: PRK11622
866895001127	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
866895001128	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895001129	S-adenosylmethionine binding site [chemical binding]; other site
866895001130	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
866895001131	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
866895001132	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
866895001133	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
866895001134	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
866895001135	HlyD family secretion protein; Region: HlyD_3; pfam13437
866895001136	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
866895001137	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
866895001138	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866895001139	MarR family; Region: MarR_2; cl17246
866895001140	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
866895001141	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
866895001142	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
866895001143	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866895001144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895001145	S-adenosylmethionine binding site [chemical binding]; other site
866895001146	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866895001147	MarR family; Region: MarR; pfam01047
866895001148	MarR family; Region: MarR_2; cl17246
866895001149	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
866895001150	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895001151	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895001152	ABC transporter; Region: ABC_tran_2; pfam12848
866895001153	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895001154	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
866895001155	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
866895001156	putative NAD(P) binding site [chemical binding]; other site
866895001157	active site
866895001158	putative substrate binding site [chemical binding]; other site
866895001159	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
866895001160	catalytic residues [active]
866895001161	Esterase/lipase [General function prediction only]; Region: COG1647
866895001162	PGAP1-like protein; Region: PGAP1; pfam07819
866895001163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895001164	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895001165	putative substrate translocation pore; other site
866895001166	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
866895001167	EDD domain protein, DegV family; Region: DegV; TIGR00762
866895001168	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
866895001169	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
866895001170	EamA-like transporter family; Region: EamA; pfam00892
866895001171	helicase 45; Provisional; Region: PTZ00424
866895001172	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866895001173	ATP binding site [chemical binding]; other site
866895001174	Mg++ binding site [ion binding]; other site
866895001175	motif III; other site
866895001176	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895001177	nucleotide binding region [chemical binding]; other site
866895001178	ATP-binding site [chemical binding]; other site
866895001179	Rhomboid family; Region: Rhomboid; pfam01694
866895001180	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
866895001181	putative carbohydrate kinase; Provisional; Region: PRK10565
866895001182	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
866895001183	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
866895001184	putative substrate binding site [chemical binding]; other site
866895001185	putative ATP binding site [chemical binding]; other site
866895001186	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
866895001187	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
866895001188	alanine racemase; Reviewed; Region: alr; PRK00053
866895001189	active site
866895001190	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866895001191	dimer interface [polypeptide binding]; other site
866895001192	substrate binding site [chemical binding]; other site
866895001193	catalytic residues [active]
866895001194	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
866895001195	PemK-like protein; Region: PemK; pfam02452
866895001196	Rsbr N terminal; Region: Rsbr_N; pfam08678
866895001197	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895001198	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895001199	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
866895001200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895001201	ATP binding site [chemical binding]; other site
866895001202	Mg2+ binding site [ion binding]; other site
866895001203	G-X-G motif; other site
866895001204	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
866895001205	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
866895001206	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
866895001207	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
866895001208	anti sigma factor interaction site; other site
866895001209	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
866895001210	regulatory phosphorylation site [posttranslational modification]; other site
866895001211	serine-protein kinase RsbW; Provisional; Region: PRK04069
866895001212	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
866895001213	ATP binding site [chemical binding]; other site
866895001214	Mg2+ binding site [ion binding]; other site
866895001215	G-X-G motif; other site
866895001216	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
866895001217	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895001218	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
866895001219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895001220	DNA binding residues [nucleotide binding]
866895001221	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
866895001222	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
866895001223	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
866895001224	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
866895001225	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
866895001226	RNA binding site [nucleotide binding]; other site
866895001227	hypothetical protein; Provisional; Region: PRK04351
866895001228	SprT homologues; Region: SprT; cl01182
866895001229	thiamine monophosphate kinase; Provisional; Region: PRK05731
866895001230	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
866895001231	ATP binding site [chemical binding]; other site
866895001232	dimerization interface [polypeptide binding]; other site
866895001233	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
866895001234	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
866895001235	Glycoprotease family; Region: Peptidase_M22; pfam00814
866895001236	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
866895001237	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895001238	Coenzyme A binding pocket [chemical binding]; other site
866895001239	UGMP family protein; Validated; Region: PRK09604
866895001240	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
866895001241	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
866895001242	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895001243	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895001244	ABC transporter; Region: ABC_tran_2; pfam12848
866895001245	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895001246	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
866895001247	trimer interface [polypeptide binding]; other site
866895001248	dimer interface [polypeptide binding]; other site
866895001249	putative active site [active]
866895001250	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
866895001251	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
866895001252	CoA binding domain; Region: CoA_binding; pfam02629
866895001253	short chain dehydrogenase; Validated; Region: PRK08589
866895001254	classical (c) SDRs; Region: SDR_c; cd05233
866895001255	NAD(P) binding site [chemical binding]; other site
866895001256	active site
866895001257	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895001258	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895001259	putative substrate translocation pore; other site
866895001260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895001261	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866895001262	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895001263	Coenzyme A binding pocket [chemical binding]; other site
866895001264	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895001265	Domain of unknown function (DUF4305); Region: DUF4305; pfam14146
866895001266	CAAX protease self-immunity; Region: Abi; pfam02517
866895001267	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
866895001268	oligomerisation interface [polypeptide binding]; other site
866895001269	mobile loop; other site
866895001270	roof hairpin; other site
866895001271	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
866895001272	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
866895001273	ring oligomerisation interface [polypeptide binding]; other site
866895001274	ATP/Mg binding site [chemical binding]; other site
866895001275	stacking interactions; other site
866895001276	hinge regions; other site
866895001277	Uncharacterized conserved protein [Function unknown]; Region: COG2966
866895001278	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
866895001279	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
866895001280	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
866895001281	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
866895001282	Spore germination protein; Region: Spore_permease; cl17796
866895001283	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
866895001284	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
866895001285	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
866895001286	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
866895001287	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
866895001288	transmembrane helices; other site
866895001289	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
866895001290	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
866895001291	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
866895001292	NAD(P) binding site [chemical binding]; other site
866895001293	homodimer interface [polypeptide binding]; other site
866895001294	substrate binding site [chemical binding]; other site
866895001295	active site
866895001296	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866895001297	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895001298	S-adenosylmethionine binding site [chemical binding]; other site
866895001299	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
866895001300	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866895001301	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
866895001302	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895001303	NAD(P) binding site [chemical binding]; other site
866895001304	active site
866895001305	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
866895001306	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
866895001307	inhibitor-cofactor binding pocket; inhibition site
866895001308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895001309	catalytic residue [active]
866895001310	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
866895001311	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
866895001312	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
866895001313	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895001314	pseudaminic acid synthase; Region: PseI; TIGR03586
866895001315	NeuB family; Region: NeuB; pfam03102
866895001316	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
866895001317	NeuB binding interface [polypeptide binding]; other site
866895001318	putative substrate binding site [chemical binding]; other site
866895001319	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
866895001320	ligand binding site; other site
866895001321	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
866895001322	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
866895001323	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866895001324	putative active site [active]
866895001325	putative metal binding site [ion binding]; other site
866895001326	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866895001327	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895001328	S-layer homology domain; Region: SLH; pfam00395
866895001329	S-layer homology domain; Region: SLH; pfam00395
866895001330	S-layer homology domain; Region: SLH; pfam00395
866895001331	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
866895001332	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
866895001333	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
866895001334	Predicted transcriptional regulators [Transcription]; Region: COG1510
866895001335	MarR family; Region: MarR_2; pfam12802
866895001336	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
866895001337	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
866895001338	tetramerization interface [polypeptide binding]; other site
866895001339	NAD(P) binding site [chemical binding]; other site
866895001340	catalytic residues [active]
866895001341	choline dehydrogenase; Validated; Region: PRK02106
866895001342	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
866895001343	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
866895001344	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
866895001345	catalytic residue [active]
866895001346	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
866895001347	catalytic residues [active]
866895001348	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895001349	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895001350	peroxiredoxin; Region: AhpC; TIGR03137
866895001351	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
866895001352	dimer interface [polypeptide binding]; other site
866895001353	decamer (pentamer of dimers) interface [polypeptide binding]; other site
866895001354	catalytic triad [active]
866895001355	peroxidatic and resolving cysteines [active]
866895001356	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
866895001357	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
866895001358	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
866895001359	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895001360	active site
866895001361	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
866895001362	NADH(P)-binding; Region: NAD_binding_10; pfam13460
866895001363	NAD(P) binding site [chemical binding]; other site
866895001364	putative active site [active]
866895001365	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
866895001366	MPN+ (JAMM) motif; other site
866895001367	Zinc-binding site [ion binding]; other site
866895001368	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
866895001369	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
866895001370	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
866895001371	DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764
866895001372	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895001373	DNA-binding site [nucleotide binding]; DNA binding site
866895001374	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
866895001375	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
866895001376	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
866895001377	NAD binding site [chemical binding]; other site
866895001378	sugar binding site [chemical binding]; other site
866895001379	divalent metal binding site [ion binding]; other site
866895001380	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
866895001381	dimer interface [polypeptide binding]; other site
866895001382	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866895001383	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
866895001384	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866895001385	active site turn [active]
866895001386	phosphorylation site [posttranslational modification]
866895001387	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026
866895001388	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
866895001389	Methyltransferase domain; Region: Methyltransf_31; pfam13847
866895001390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895001391	S-adenosylmethionine binding site [chemical binding]; other site
866895001392	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
866895001393	Predicted membrane protein [Function unknown]; Region: COG2323
866895001394	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
866895001395	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
866895001396	metal binding triad; other site
866895001397	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
866895001398	hypothetical protein; Provisional; Region: PRK07740
866895001399	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
866895001400	active site
866895001401	catalytic site [active]
866895001402	substrate binding site [chemical binding]; other site
866895001403	Uncharacterized conserved protein [Function unknown]; Region: COG0397
866895001404	hypothetical protein; Validated; Region: PRK00029
866895001405	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895001406	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895001407	Probable transposase; Region: OrfB_IS605; pfam01385
866895001408	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895001409	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
866895001410	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
866895001411	Spore Coat Protein X and V domain; Region: Coat_X; pfam07552
866895001412	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
866895001413	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
866895001414	active site
866895001415	catalytic triad [active]
866895001416	oxyanion hole [active]
866895001417	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895001418	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
866895001419	dimer interface [polypeptide binding]; other site
866895001420	putative metal binding site [ion binding]; other site
866895001421	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
866895001422	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
866895001423	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
866895001424	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
866895001425	Domain of unknown function DUF21; Region: DUF21; pfam01595
866895001426	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866895001427	Transporter associated domain; Region: CorC_HlyC; pfam03471
866895001428	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
866895001429	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895001430	Transcriptional regulator [Transcription]; Region: IclR; COG1414
866895001431	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895001432	putative DNA binding site [nucleotide binding]; other site
866895001433	putative Zn2+ binding site [ion binding]; other site
866895001434	Bacterial transcriptional regulator; Region: IclR; pfam01614
866895001435	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
866895001436	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
866895001437	active site
866895001438	intersubunit interface [polypeptide binding]; other site
866895001439	catalytic residue [active]
866895001440	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
866895001441	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
866895001442	galactonate dehydratase; Provisional; Region: PRK14017
866895001443	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
866895001444	putative active site pocket [active]
866895001445	putative metal binding site [ion binding]; other site
866895001446	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
866895001447	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
866895001448	N- and C-terminal domain interface [polypeptide binding]; other site
866895001449	active site
866895001450	catalytic site [active]
866895001451	metal binding site [ion binding]; metal-binding site
866895001452	carbohydrate binding site [chemical binding]; other site
866895001453	ATP binding site [chemical binding]; other site
866895001454	fructuronate transporter; Provisional; Region: PRK10034; cl15264
866895001455	GntP family permease; Region: GntP_permease; pfam02447
866895001456	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
866895001457	active site
866895001458	substrate binding pocket [chemical binding]; other site
866895001459	homodimer interaction site [polypeptide binding]; other site
866895001460	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895001461	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895001462	OsmC-like protein; Region: OsmC; pfam02566
866895001463	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
866895001464	active site residue [active]
866895001465	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
866895001466	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
866895001467	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
866895001468	active site
866895001469	NTP binding site [chemical binding]; other site
866895001470	metal binding triad [ion binding]; metal-binding site
866895001471	antibiotic binding site [chemical binding]; other site
866895001472	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
866895001473	allantoate amidohydrolase; Reviewed; Region: PRK09290
866895001474	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
866895001475	active site
866895001476	metal binding site [ion binding]; metal-binding site
866895001477	dimer interface [polypeptide binding]; other site
866895001478	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
866895001479	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
866895001480	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866895001481	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866895001482	AAA ATPase domain; Region: AAA_16; pfam13191
866895001483	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895001484	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895001485	DNA binding residues [nucleotide binding]
866895001486	dimerization interface [polypeptide binding]; other site
866895001487	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895001488	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895001489	Coenzyme A binding pocket [chemical binding]; other site
866895001490	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
866895001491	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895001492	inhibitor-cofactor binding pocket; inhibition site
866895001493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895001494	catalytic residue [active]
866895001495	Ectoine synthase; Region: Ectoine_synth; pfam06339
866895001496	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895001497	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866895001498	active site
866895001499	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
866895001500	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
866895001501	NAD(P) binding site [chemical binding]; other site
866895001502	homotetramer interface [polypeptide binding]; other site
866895001503	homodimer interface [polypeptide binding]; other site
866895001504	active site
866895001505	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
866895001506	active site
866895001507	catalytic site [active]
866895001508	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
866895001509	active site 2 [active]
866895001510	active site 1 [active]
866895001511	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895001512	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
866895001513	FAD binding site [chemical binding]; other site
866895001514	substrate binding site [chemical binding]; other site
866895001515	catalytic base [active]
866895001516	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
866895001517	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895001518	NAD(P) binding site [chemical binding]; other site
866895001519	active site
866895001520	putative acyltransferase; Provisional; Region: PRK05790
866895001521	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866895001522	dimer interface [polypeptide binding]; other site
866895001523	active site
866895001524	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895001525	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895001526	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
866895001527	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
866895001528	active site
866895001529	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
866895001530	classical (c) SDRs; Region: SDR_c; cd05233
866895001531	NAD(P) binding site [chemical binding]; other site
866895001532	active site
866895001533	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
866895001534	Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935
866895001535	acyl-activating enzyme (AAE) consensus motif; other site
866895001536	putative AMP binding site [chemical binding]; other site
866895001537	putative active site [active]
866895001538	putative CoA binding site [chemical binding]; other site
866895001539	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866895001540	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
866895001541	TM-ABC transporter signature motif; other site
866895001542	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
866895001543	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
866895001544	TM-ABC transporter signature motif; other site
866895001545	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
866895001546	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
866895001547	Walker A/P-loop; other site
866895001548	ATP binding site [chemical binding]; other site
866895001549	Q-loop/lid; other site
866895001550	ABC transporter signature motif; other site
866895001551	Walker B; other site
866895001552	D-loop; other site
866895001553	H-loop/switch region; other site
866895001554	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
866895001555	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
866895001556	Walker A/P-loop; other site
866895001557	ATP binding site [chemical binding]; other site
866895001558	Q-loop/lid; other site
866895001559	ABC transporter signature motif; other site
866895001560	Walker B; other site
866895001561	D-loop; other site
866895001562	H-loop/switch region; other site
866895001563	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
866895001564	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
866895001565	putative ligand binding site [chemical binding]; other site
866895001566	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895001567	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866895001568	active site
866895001569	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
866895001570	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
866895001571	acyl-activating enzyme (AAE) consensus motif; other site
866895001572	putative active site [active]
866895001573	putative AMP binding site [chemical binding]; other site
866895001574	putative CoA binding site [chemical binding]; other site
866895001575	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895001576	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866895001577	active site
866895001578	putative acyltransferase; Provisional; Region: PRK05790
866895001579	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866895001580	dimer interface [polypeptide binding]; other site
866895001581	active site
866895001582	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
866895001583	CoenzymeA binding site [chemical binding]; other site
866895001584	subunit interaction site [polypeptide binding]; other site
866895001585	PHB binding site; other site
866895001586	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
866895001587	CoenzymeA binding site [chemical binding]; other site
866895001588	subunit interaction site [polypeptide binding]; other site
866895001589	PHB binding site; other site
866895001590	Uncharacterized conserved protein [Function unknown]; Region: COG3189
866895001591	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
866895001592	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
866895001593	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
866895001594	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
866895001595	allantoate amidohydrolase; Reviewed; Region: PRK09290
866895001596	active site
866895001597	metal binding site [ion binding]; metal-binding site
866895001598	dimer interface [polypeptide binding]; other site
866895001599	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866895001600	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
866895001601	putative metal binding site [ion binding]; other site
866895001602	dimer interface [polypeptide binding]; other site
866895001603	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866895001604	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
866895001605	metal binding site [ion binding]; metal-binding site
866895001606	dimer interface [polypeptide binding]; other site
866895001607	Ion channel; Region: Ion_trans_2; pfam07885
866895001608	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
866895001609	TrkA-N domain; Region: TrkA_N; pfam02254
866895001610	TrkA-C domain; Region: TrkA_C; pfam02080
866895001611	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866895001612	DNA-binding site [nucleotide binding]; DNA binding site
866895001613	RNA-binding motif; other site
866895001614	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866895001615	DNA-binding site [nucleotide binding]; DNA binding site
866895001616	RNA-binding motif; other site
866895001617	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
866895001618	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
866895001619	dimer interface [polypeptide binding]; other site
866895001620	active site
866895001621	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866895001622	active site residue [active]
866895001623	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
866895001624	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
866895001625	NodB motif; other site
866895001626	active site
866895001627	catalytic site [active]
866895001628	metal binding site [ion binding]; metal-binding site
866895001629	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895001630	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895001631	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895001632	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866895001633	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866895001634	substrate binding pocket [chemical binding]; other site
866895001635	membrane-bound complex binding site; other site
866895001636	hinge residues; other site
866895001637	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866895001638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895001639	dimer interface [polypeptide binding]; other site
866895001640	conserved gate region; other site
866895001641	putative PBP binding loops; other site
866895001642	ABC-ATPase subunit interface; other site
866895001643	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866895001644	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866895001645	Walker A/P-loop; other site
866895001646	ATP binding site [chemical binding]; other site
866895001647	Q-loop/lid; other site
866895001648	ABC transporter signature motif; other site
866895001649	Walker B; other site
866895001650	D-loop; other site
866895001651	H-loop/switch region; other site
866895001652	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
866895001653	active site
866895001654	Zn binding site [ion binding]; other site
866895001655	YjzC-like protein; Region: YjzC; pfam14168
866895001656	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
866895001657	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895001658	Zn binding site [ion binding]; other site
866895001659	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
866895001660	Zn binding site [ion binding]; other site
866895001661	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
866895001662	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
866895001663	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
866895001664	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866895001665	catalytic residues [active]
866895001666	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866895001667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895001668	active site
866895001669	phosphorylation site [posttranslational modification]
866895001670	intermolecular recognition site; other site
866895001671	dimerization interface [polypeptide binding]; other site
866895001672	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866895001673	DNA binding site [nucleotide binding]
866895001674	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866895001675	HAMP domain; Region: HAMP; pfam00672
866895001676	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866895001677	dimer interface [polypeptide binding]; other site
866895001678	phosphorylation site [posttranslational modification]
866895001679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895001680	ATP binding site [chemical binding]; other site
866895001681	Mg2+ binding site [ion binding]; other site
866895001682	G-X-G motif; other site
866895001683	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
866895001684	E-class dimer interface [polypeptide binding]; other site
866895001685	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
866895001686	P-class dimer interface [polypeptide binding]; other site
866895001687	active site
866895001688	Cu2+ binding site [ion binding]; other site
866895001689	Zn2+ binding site [ion binding]; other site
866895001690	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
866895001691	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
866895001692	NAD binding site [chemical binding]; other site
866895001693	catalytic Zn binding site [ion binding]; other site
866895001694	structural Zn binding site [ion binding]; other site
866895001695	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
866895001696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895001697	S-adenosylmethionine binding site [chemical binding]; other site
866895001698	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
866895001699	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
866895001700	active site
866895001701	metal binding site [ion binding]; metal-binding site
866895001702	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
866895001703	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
866895001704	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
866895001705	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
866895001706	N- and C-terminal domain interface [polypeptide binding]; other site
866895001707	active site
866895001708	MgATP binding site [chemical binding]; other site
866895001709	catalytic site [active]
866895001710	metal binding site [ion binding]; metal-binding site
866895001711	xylulose binding site [chemical binding]; other site
866895001712	putative homodimer interface [polypeptide binding]; other site
866895001713	MoxR-like ATPases [General function prediction only]; Region: COG0714
866895001714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895001715	Walker A motif; other site
866895001716	ATP binding site [chemical binding]; other site
866895001717	Walker B motif; other site
866895001718	arginine finger; other site
866895001719	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
866895001720	Protein of unknown function DUF58; Region: DUF58; pfam01882
866895001721	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
866895001722	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
866895001723	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
866895001724	GMP synthase; Reviewed; Region: guaA; PRK00074
866895001725	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
866895001726	AMP/PPi binding site [chemical binding]; other site
866895001727	candidate oxyanion hole; other site
866895001728	catalytic triad [active]
866895001729	potential glutamine specificity residues [chemical binding]; other site
866895001730	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
866895001731	ATP Binding subdomain [chemical binding]; other site
866895001732	Ligand Binding sites [chemical binding]; other site
866895001733	Dimerization subdomain; other site
866895001734	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
866895001735	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
866895001736	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
866895001737	putative dimer interface [polypeptide binding]; other site
866895001738	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
866895001739	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
866895001740	NETI protein; Region: NETI; pfam14044
866895001741	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
866895001742	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
866895001743	XdhC Rossmann domain; Region: XdhC_C; pfam13478
866895001744	ATP-grasp domain; Region: ATP-grasp; pfam02222
866895001745	adenylosuccinate lyase; Provisional; Region: PRK07492
866895001746	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
866895001747	tetramer interface [polypeptide binding]; other site
866895001748	active site
866895001749	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
866895001750	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
866895001751	ATP binding site [chemical binding]; other site
866895001752	active site
866895001753	substrate binding site [chemical binding]; other site
866895001754	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
866895001755	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
866895001756	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
866895001757	putative active site [active]
866895001758	catalytic triad [active]
866895001759	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
866895001760	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
866895001761	dimerization interface [polypeptide binding]; other site
866895001762	ATP binding site [chemical binding]; other site
866895001763	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
866895001764	dimerization interface [polypeptide binding]; other site
866895001765	ATP binding site [chemical binding]; other site
866895001766	amidophosphoribosyltransferase; Provisional; Region: PRK07631
866895001767	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
866895001768	active site
866895001769	tetramer interface [polypeptide binding]; other site
866895001770	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895001771	active site
866895001772	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
866895001773	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
866895001774	dimerization interface [polypeptide binding]; other site
866895001775	putative ATP binding site [chemical binding]; other site
866895001776	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
866895001777	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
866895001778	active site
866895001779	substrate binding site [chemical binding]; other site
866895001780	cosubstrate binding site; other site
866895001781	catalytic site [active]
866895001782	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
866895001783	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
866895001784	purine monophosphate binding site [chemical binding]; other site
866895001785	dimer interface [polypeptide binding]; other site
866895001786	putative catalytic residues [active]
866895001787	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
866895001788	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
866895001789	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
866895001790	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
866895001791	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
866895001792	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
866895001793	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
866895001794	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
866895001795	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
866895001796	active site
866895001797	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
866895001798	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
866895001799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
866895001800	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
866895001801	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
866895001802	homodimer interface [polypeptide binding]; other site
866895001803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895001804	catalytic residue [active]
866895001805	Uncharacterized conserved protein [Function unknown]; Region: COG1284
866895001806	PcrB family; Region: PcrB; pfam01884
866895001807	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
866895001808	substrate binding site [chemical binding]; other site
866895001809	putative active site [active]
866895001810	dimer interface [polypeptide binding]; other site
866895001811	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
866895001812	Part of AAA domain; Region: AAA_19; pfam13245
866895001813	Family description; Region: UvrD_C_2; pfam13538
866895001814	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
866895001815	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
866895001816	nucleotide binding pocket [chemical binding]; other site
866895001817	K-X-D-G motif; other site
866895001818	catalytic site [active]
866895001819	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
866895001820	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
866895001821	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
866895001822	Dimer interface [polypeptide binding]; other site
866895001823	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
866895001824	putative dimer interface [polypeptide binding]; other site
866895001825	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
866895001826	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
866895001827	putative dimer interface [polypeptide binding]; other site
866895001828	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
866895001829	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
866895001830	Glutamate binding site [chemical binding]; other site
866895001831	homodimer interface [polypeptide binding]; other site
866895001832	NAD binding site [chemical binding]; other site
866895001833	catalytic residues [active]
866895001834	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
866895001835	Na binding site [ion binding]; other site
866895001836	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
866895001837	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
866895001838	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
866895001839	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
866895001840	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
866895001841	GatB domain; Region: GatB_Yqey; smart00845
866895001842	putative lipid kinase; Reviewed; Region: PRK13337
866895001843	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
866895001844	TRAM domain; Region: TRAM; pfam01938
866895001845	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
866895001846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
866895001847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895001848	S-adenosylmethionine binding site [chemical binding]; other site
866895001849	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
866895001850	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
866895001851	Int/Topo IB signature motif; other site
866895001852	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
866895001853	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866895001854	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895001855	non-specific DNA binding site [nucleotide binding]; other site
866895001856	salt bridge; other site
866895001857	sequence-specific DNA binding site [nucleotide binding]; other site
866895001858	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895001859	sequence-specific DNA binding site [nucleotide binding]; other site
866895001860	salt bridge; other site
866895001861	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
866895001862	ORF6C domain; Region: ORF6C; pfam10552
866895001863	Helix-turn-helix domain; Region: HTH_19; pfam12844
866895001864	non-specific DNA binding site [nucleotide binding]; other site
866895001865	salt bridge; other site
866895001866	sequence-specific DNA binding site [nucleotide binding]; other site
866895001867	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
866895001868	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
866895001869	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866895001870	Walker A motif; other site
866895001871	ATP binding site [chemical binding]; other site
866895001872	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
866895001873	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
866895001874	AF-4 proto-oncoprotein; Region: AF-4; pfam05110
866895001875	AAA-like domain; Region: AAA_10; pfam12846
866895001876	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
866895001877	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866895001878	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866895001879	catalytic residue [active]
866895001880	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
866895001881	Peptidase family M23; Region: Peptidase_M23; pfam01551
866895001882	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
866895001883	Domain of unknown function (DUF955); Region: DUF955; pfam06114
866895001884	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
866895001885	Toprim-like; Region: Toprim_2; pfam13155
866895001886	active site
866895001887	metal binding site [ion binding]; metal-binding site
866895001888	SprT homologues; Region: SprT; cl01182
866895001889	WYL domain; Region: WYL; pfam13280
866895001890	YolD-like protein; Region: YolD; pfam08863
866895001891	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
866895001892	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866895001893	active site
866895001894	DNA binding site [nucleotide binding]
866895001895	Int/Topo IB signature motif; other site
866895001896	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895001897	Coenzyme A binding pocket [chemical binding]; other site
866895001898	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
866895001899	RDD family; Region: RDD; pfam06271
866895001900	CAAX protease self-immunity; Region: Abi; pfam02517
866895001901	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
866895001902	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
866895001903	putative active site [active]
866895001904	putative NTP binding site [chemical binding]; other site
866895001905	putative nucleic acid binding site [nucleotide binding]; other site
866895001906	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
866895001907	active site
866895001908	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556
866895001909	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
866895001910	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
866895001911	dimer interface [polypeptide binding]; other site
866895001912	active site
866895001913	heme binding site [chemical binding]; other site
866895001914	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
866895001915	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
866895001916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895001917	S-adenosylmethionine binding site [chemical binding]; other site
866895001918	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
866895001919	Sodium Bile acid symporter family; Region: SBF; cl17470
866895001920	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
866895001921	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
866895001922	Part of AAA domain; Region: AAA_19; pfam13245
866895001923	Family description; Region: UvrD_C_2; pfam13538
866895001924	Helix-turn-helix domain; Region: HTH_36; pfam13730
866895001925	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
866895001926	DNA photolyase; Region: DNA_photolyase; pfam00875
866895001927	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
866895001928	Divergent PAP2 family; Region: DUF212; pfam02681
866895001929	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866895001930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895001931	S-adenosylmethionine binding site [chemical binding]; other site
866895001932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895001933	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895001934	putative substrate translocation pore; other site
866895001935	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
866895001936	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895001937	Uncharacterized conserved protein [Function unknown]; Region: COG3339
866895001938	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
866895001939	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
866895001940	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
866895001941	cystathionine beta-lyase; Provisional; Region: PRK08064
866895001942	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866895001943	homodimer interface [polypeptide binding]; other site
866895001944	substrate-cofactor binding pocket; other site
866895001945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895001946	catalytic residue [active]
866895001947	cystathionine gamma-synthase; Reviewed; Region: PRK08247
866895001948	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866895001949	homodimer interface [polypeptide binding]; other site
866895001950	substrate-cofactor binding pocket; other site
866895001951	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895001952	catalytic residue [active]
866895001953	Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107
866895001954	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
866895001955	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
866895001956	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
866895001957	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895001958	NAD(P) binding site [chemical binding]; other site
866895001959	active site
866895001960	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
866895001961	Predicted transcriptional regulators [Transcription]; Region: COG1725
866895001962	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895001963	DNA-binding site [nucleotide binding]; DNA binding site
866895001964	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
866895001965	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895001966	Walker A/P-loop; other site
866895001967	ATP binding site [chemical binding]; other site
866895001968	Q-loop/lid; other site
866895001969	ABC transporter signature motif; other site
866895001970	Walker B; other site
866895001971	D-loop; other site
866895001972	H-loop/switch region; other site
866895001973	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
866895001974	Sulfatase; Region: Sulfatase; pfam00884
866895001975	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
866895001976	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
866895001977	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866895001978	catalytic residue [active]
866895001979	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
866895001980	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
866895001981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895001982	dimer interface [polypeptide binding]; other site
866895001983	conserved gate region; other site
866895001984	putative PBP binding loops; other site
866895001985	ABC-ATPase subunit interface; other site
866895001986	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
866895001987	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
866895001988	Walker A/P-loop; other site
866895001989	ATP binding site [chemical binding]; other site
866895001990	Q-loop/lid; other site
866895001991	ABC transporter signature motif; other site
866895001992	Walker B; other site
866895001993	D-loop; other site
866895001994	H-loop/switch region; other site
866895001995	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
866895001996	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866895001997	substrate binding pocket [chemical binding]; other site
866895001998	membrane-bound complex binding site; other site
866895001999	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
866895002000	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
866895002001	D-serine dehydratase; Provisional; Region: PRK02991
866895002002	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
866895002003	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866895002004	catalytic residue [active]
866895002005	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
866895002006	classical (c) SDRs; Region: SDR_c; cd05233
866895002007	NAD(P) binding site [chemical binding]; other site
866895002008	active site
866895002009	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
866895002010	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
866895002011	transmembrane helices; other site
866895002012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895002013	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895002014	putative substrate translocation pore; other site
866895002015	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
866895002016	classical (c) SDRs; Region: SDR_c; cd05233
866895002017	NAD(P) binding site [chemical binding]; other site
866895002018	active site
866895002019	Nuclease-related domain; Region: NERD; pfam08378
866895002020	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
866895002021	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866895002022	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866895002023	active site turn [active]
866895002024	phosphorylation site [posttranslational modification]
866895002025	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
866895002026	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
866895002027	active site
866895002028	dimer interface [polypeptide binding]; other site
866895002029	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
866895002030	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
866895002031	active site
866895002032	trimer interface [polypeptide binding]; other site
866895002033	allosteric site; other site
866895002034	active site lid [active]
866895002035	hexamer (dimer of trimers) interface [polypeptide binding]; other site
866895002036	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
866895002037	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895002038	DNA-binding site [nucleotide binding]; DNA binding site
866895002039	UTRA domain; Region: UTRA; pfam07702
866895002040	hypothetical protein; Provisional; Region: PRK02947
866895002041	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866895002042	putative active site [active]
866895002043	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895002044	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895002045	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
866895002046	NADH(P)-binding; Region: NAD_binding_10; pfam13460
866895002047	NADP binding site [chemical binding]; other site
866895002048	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
866895002049	NADH(P)-binding; Region: NAD_binding_10; pfam13460
866895002050	NAD binding site [chemical binding]; other site
866895002051	substrate binding site [chemical binding]; other site
866895002052	putative active site [active]
866895002053	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866895002054	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866895002055	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
866895002056	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
866895002057	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
866895002058	DNA binding residues [nucleotide binding]
866895002059	putative dimer interface [polypeptide binding]; other site
866895002060	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
866895002061	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866895002062	Transposase; Region: HTH_Tnp_1; cl17663
866895002063	putative transposase OrfB; Reviewed; Region: PHA02517
866895002064	HTH-like domain; Region: HTH_21; pfam13276
866895002065	Integrase core domain; Region: rve; pfam00665
866895002066	Integrase core domain; Region: rve_3; pfam13683
866895002067	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
866895002068	Cytochrome P450; Region: p450; cl12078
866895002069	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
866895002070	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
866895002071	BCCT family transporter; Region: BCCT; pfam02028
866895002072	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895002073	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895002074	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866895002075	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895002076	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866895002077	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895002078	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
866895002079	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
866895002080	Helix-turn-helix domain; Region: HTH_17; cl17695
866895002081	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
866895002082	homotrimer interaction site [polypeptide binding]; other site
866895002083	putative active site [active]
866895002084	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
866895002085	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
866895002086	Carbon starvation protein CstA; Region: CstA; pfam02554
866895002087	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
866895002088	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
866895002089	putative catalytic residues [active]
866895002090	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866895002091	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
866895002092	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
866895002093	active site
866895002094	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
866895002095	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
866895002096	Walker A/P-loop; other site
866895002097	ATP binding site [chemical binding]; other site
866895002098	Q-loop/lid; other site
866895002099	ABC transporter signature motif; other site
866895002100	Walker B; other site
866895002101	D-loop; other site
866895002102	H-loop/switch region; other site
866895002103	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
866895002104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
866895002105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895002106	putative PBP binding loops; other site
866895002107	ABC-ATPase subunit interface; other site
866895002108	Domain of unknown function DUF77; Region: DUF77; pfam01910
866895002109	NMT1/THI5 like; Region: NMT1; pfam09084
866895002110	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866895002111	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
866895002112	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895002113	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
866895002114	active site
866895002115	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
866895002116	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
866895002117	Ligand Binding Site [chemical binding]; other site
866895002118	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
866895002119	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
866895002120	NAD binding site [chemical binding]; other site
866895002121	homotetramer interface [polypeptide binding]; other site
866895002122	homodimer interface [polypeptide binding]; other site
866895002123	substrate binding site [chemical binding]; other site
866895002124	active site
866895002125	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
866895002126	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
866895002127	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
866895002128	NAD(P) binding site [chemical binding]; other site
866895002129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895002130	putative substrate translocation pore; other site
866895002131	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
866895002132	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
866895002133	PLD-like domain; Region: PLDc_2; pfam13091
866895002134	putative active site [active]
866895002135	catalytic site [active]
866895002136	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
866895002137	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
866895002138	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
866895002139	Strictosidine synthase; Region: Str_synth; pfam03088
866895002140	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895002141	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895002142	Coenzyme A binding pocket [chemical binding]; other site
866895002143	Predicted transcriptional regulators [Transcription]; Region: COG1695
866895002144	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
866895002145	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
866895002146	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
866895002147	DinB superfamily; Region: DinB_2; pfam12867
866895002148	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
866895002149	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
866895002150	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
866895002151	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
866895002152	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
866895002153	methionine sulfoxide reductase A; Provisional; Region: PRK14054
866895002154	ethanolamine utilization protein EutH; Provisional; Region: PRK15086
866895002155	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
866895002156	putative catalytic residues [active]
866895002157	Protein of unknown function (DUF458); Region: DUF458; pfam04308
866895002158	Protein of unknown function (DUF867); Region: DUF867; pfam05908
866895002159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895002160	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895002161	putative substrate translocation pore; other site
866895002162	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
866895002163	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
866895002164	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
866895002165	active site
866895002166	HIGH motif; other site
866895002167	KMSK motif region; other site
866895002168	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
866895002169	tRNA binding surface [nucleotide binding]; other site
866895002170	anticodon binding site; other site
866895002171	Predicted membrane protein [Function unknown]; Region: COG2323
866895002172	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866895002173	catalytic residues [active]
866895002174	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
866895002175	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
866895002176	gamma-glutamyl kinase; Provisional; Region: PRK13402
866895002177	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
866895002178	nucleotide binding site [chemical binding]; other site
866895002179	homotetrameric interface [polypeptide binding]; other site
866895002180	putative phosphate binding site [ion binding]; other site
866895002181	putative allosteric binding site; other site
866895002182	PUA domain; Region: PUA; pfam01472
866895002183	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
866895002184	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
866895002185	putative catalytic cysteine [active]
866895002186	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895002187	DinB family; Region: DinB; cl17821
866895002188	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
866895002189	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895002190	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
866895002191	FAD binding site [chemical binding]; other site
866895002192	substrate binding site [chemical binding]; other site
866895002193	catalytic base [active]
866895002194	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
866895002195	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895002196	NAD(P) binding site [chemical binding]; other site
866895002197	active site
866895002198	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
866895002199	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
866895002200	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
866895002201	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
866895002202	active site
866895002203	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
866895002204	Phosphotransferase enzyme family; Region: APH; pfam01636
866895002205	putative active site [active]
866895002206	putative substrate binding site [chemical binding]; other site
866895002207	ATP binding site [chemical binding]; other site
866895002208	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
866895002209	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
866895002210	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866895002211	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895002212	active site
866895002213	enoyl-CoA hydratase; Provisional; Region: PRK06688
866895002214	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866895002215	substrate binding site [chemical binding]; other site
866895002216	oxyanion hole (OAH) forming residues; other site
866895002217	trimer interface [polypeptide binding]; other site
866895002218	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
866895002219	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
866895002220	NADP binding site [chemical binding]; other site
866895002221	dimer interface [polypeptide binding]; other site
866895002222	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866895002223	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895002224	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
866895002225	active site
866895002226	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866895002227	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866895002228	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
866895002229	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
866895002230	homodimer interface [polypeptide binding]; other site
866895002231	substrate-cofactor binding pocket; other site
866895002232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895002233	catalytic residue [active]
866895002234	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
866895002235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895002236	S-adenosylmethionine binding site [chemical binding]; other site
866895002237	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
866895002238	putative active site [active]
866895002239	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
866895002240	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
866895002241	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
866895002242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
866895002243	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
866895002244	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
866895002245	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
866895002246	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
866895002247	putative NADP binding site [chemical binding]; other site
866895002248	putative dimer interface [polypeptide binding]; other site
866895002249	PAS domain; Region: PAS; smart00091
866895002250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895002251	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
866895002252	Walker A motif; other site
866895002253	ATP binding site [chemical binding]; other site
866895002254	Walker B motif; other site
866895002255	arginine finger; other site
866895002256	RQC domain; Region: RQC; cl09632
866895002257	hypothetical protein; Provisional; Region: PRK11588
866895002258	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
866895002259	isoaspartyl dipeptidase; Provisional; Region: PRK10657
866895002260	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
866895002261	active site
866895002262	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
866895002263	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
866895002264	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
866895002265	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
866895002266	rod-share determining protein MreBH; Provisional; Region: PRK13929
866895002267	MreB and similar proteins; Region: MreB_like; cd10225
866895002268	nucleotide binding site [chemical binding]; other site
866895002269	Mg binding site [ion binding]; other site
866895002270	putative protofilament interaction site [polypeptide binding]; other site
866895002271	RodZ interaction site [polypeptide binding]; other site
866895002272	Flagellin N-methylase; Region: FliB; pfam03692
866895002273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
866895002274	MOSC domain; Region: MOSC; pfam03473
866895002275	3-alpha domain; Region: 3-alpha; pfam03475
866895002276	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
866895002277	nucleoside/Zn binding site; other site
866895002278	dimer interface [polypeptide binding]; other site
866895002279	catalytic motif [active]
866895002280	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
866895002281	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
866895002282	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
866895002283	Walker A/P-loop; other site
866895002284	ATP binding site [chemical binding]; other site
866895002285	Q-loop/lid; other site
866895002286	ABC transporter signature motif; other site
866895002287	Walker B; other site
866895002288	D-loop; other site
866895002289	H-loop/switch region; other site
866895002290	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
866895002291	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
866895002292	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
866895002293	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895002294	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895002295	Uncharacterized conserved protein [Function unknown]; Region: COG2135
866895002296	PAS domain S-box; Region: sensory_box; TIGR00229
866895002297	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866895002298	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866895002299	metal binding site [ion binding]; metal-binding site
866895002300	active site
866895002301	I-site; other site
866895002302	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866895002303	CAAX protease self-immunity; Region: Abi; pfam02517
866895002304	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
866895002305	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
866895002306	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
866895002307	Low molecular weight phosphatase family; Region: LMWPc; cd00115
866895002308	active site
866895002309	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
866895002310	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
866895002311	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866895002312	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895002313	motif II; other site
866895002314	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866895002315	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866895002316	substrate binding pocket [chemical binding]; other site
866895002317	membrane-bound complex binding site; other site
866895002318	hinge residues; other site
866895002319	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866895002320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895002321	dimer interface [polypeptide binding]; other site
866895002322	conserved gate region; other site
866895002323	putative PBP binding loops; other site
866895002324	ABC-ATPase subunit interface; other site
866895002325	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
866895002326	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
866895002327	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
866895002328	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866895002329	ABC-ATPase subunit  interface; other site
866895002330	dimer interface [polypeptide binding]; other site
866895002331	putative PBP binding regions; other site
866895002332	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
866895002333	metal binding site 2 [ion binding]; metal-binding site
866895002334	putative DNA binding helix; other site
866895002335	metal binding site 1 [ion binding]; metal-binding site
866895002336	dimer interface [polypeptide binding]; other site
866895002337	structural Zn2+ binding site [ion binding]; other site
866895002338	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
866895002339	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
866895002340	metal binding site [ion binding]; metal-binding site
866895002341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895002342	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895002343	putative substrate translocation pore; other site
866895002344	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
866895002345	Predicted membrane protein [Function unknown]; Region: COG2364
866895002346	YfkD-like protein; Region: YfkD; pfam14167
866895002347	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866895002348	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866895002349	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866895002350	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895002351	Walker A/P-loop; other site
866895002352	ATP binding site [chemical binding]; other site
866895002353	Q-loop/lid; other site
866895002354	ABC transporter signature motif; other site
866895002355	Walker B; other site
866895002356	D-loop; other site
866895002357	H-loop/switch region; other site
866895002358	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
866895002359	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
866895002360	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866895002361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895002362	active site
866895002363	phosphorylation site [posttranslational modification]
866895002364	intermolecular recognition site; other site
866895002365	dimerization interface [polypeptide binding]; other site
866895002366	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866895002367	DNA binding site [nucleotide binding]
866895002368	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866895002369	dimerization interface [polypeptide binding]; other site
866895002370	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866895002371	dimer interface [polypeptide binding]; other site
866895002372	phosphorylation site [posttranslational modification]
866895002373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895002374	ATP binding site [chemical binding]; other site
866895002375	Mg2+ binding site [ion binding]; other site
866895002376	G-X-G motif; other site
866895002377	Predicted permease [General function prediction only]; Region: COG2056
866895002378	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
866895002379	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
866895002380	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
866895002381	NodB motif; other site
866895002382	active site
866895002383	catalytic site [active]
866895002384	Cd binding site [ion binding]; other site
866895002385	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866895002386	endonuclease III; Region: ENDO3c; smart00478
866895002387	minor groove reading motif; other site
866895002388	helix-hairpin-helix signature motif; other site
866895002389	substrate binding pocket [chemical binding]; other site
866895002390	active site
866895002391	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895002392	PAS domain; Region: PAS_9; pfam13426
866895002393	putative active site [active]
866895002394	heme pocket [chemical binding]; other site
866895002395	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
866895002396	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895002397	putative active site [active]
866895002398	heme pocket [chemical binding]; other site
866895002399	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866895002400	dimer interface [polypeptide binding]; other site
866895002401	phosphorylation site [posttranslational modification]
866895002402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895002403	ATP binding site [chemical binding]; other site
866895002404	Mg2+ binding site [ion binding]; other site
866895002405	G-X-G motif; other site
866895002406	Uncharacterized conserved protein [Function unknown]; Region: COG1284
866895002407	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
866895002408	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
866895002409	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
866895002410	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
866895002411	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
866895002412	active site
866895002413	acyl-activating enzyme (AAE) consensus motif; other site
866895002414	putative CoA binding site [chemical binding]; other site
866895002415	AMP binding site [chemical binding]; other site
866895002416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895002417	Coenzyme A binding pocket [chemical binding]; other site
866895002418	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
866895002419	BCCT family transporter; Region: BCCT; pfam02028
866895002420	Protein of unknown function (DUF3951); Region: DUF3951; pfam13131
866895002421	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
866895002422	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
866895002423	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
866895002424	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
866895002425	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
866895002426	active site
866895002427	P-loop; other site
866895002428	phosphorylation site [posttranslational modification]
866895002429	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
866895002430	active site
866895002431	P-loop; other site
866895002432	phosphorylation site [posttranslational modification]
866895002433	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
866895002434	HTH domain; Region: HTH_11; pfam08279
866895002435	HTH domain; Region: HTH_11; pfam08279
866895002436	PRD domain; Region: PRD; pfam00874
866895002437	PRD domain; Region: PRD; pfam00874
866895002438	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
866895002439	active site
866895002440	P-loop; other site
866895002441	phosphorylation site [posttranslational modification]
866895002442	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
866895002443	active site
866895002444	phosphorylation site [posttranslational modification]
866895002445	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866895002446	active site
866895002447	phosphorylation site [posttranslational modification]
866895002448	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
866895002449	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
866895002450	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
866895002451	PilZ domain; Region: PilZ; pfam07238
866895002452	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
866895002453	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
866895002454	active site
866895002455	Zn binding site [ion binding]; other site
866895002456	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
866895002457	aromatic arch; other site
866895002458	DCoH dimer interaction site [polypeptide binding]; other site
866895002459	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
866895002460	DCoH tetramer interaction site [polypeptide binding]; other site
866895002461	substrate binding site [chemical binding]; other site
866895002462	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
866895002463	putative hydrophobic ligand binding site [chemical binding]; other site
866895002464	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866895002465	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866895002466	active site
866895002467	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
866895002468	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
866895002469	G1 box; other site
866895002470	putative GEF interaction site [polypeptide binding]; other site
866895002471	GTP/Mg2+ binding site [chemical binding]; other site
866895002472	Switch I region; other site
866895002473	G2 box; other site
866895002474	G3 box; other site
866895002475	Switch II region; other site
866895002476	G4 box; other site
866895002477	G5 box; other site
866895002478	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
866895002479	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
866895002480	YtkA-like; Region: YtkA; pfam13115
866895002481	YtkA-like; Region: YtkA; pfam13115
866895002482	bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000
866895002483	Predicted membrane protein [Function unknown]; Region: COG2364
866895002484	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
866895002485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895002486	putative substrate translocation pore; other site
866895002487	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895002488	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895002489	Probable transposase; Region: OrfB_IS605; pfam01385
866895002490	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895002491	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
866895002492	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895002493	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866895002494	active site
866895002495	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
866895002496	CoA-transferase family III; Region: CoA_transf_3; pfam02515
866895002497	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
866895002498	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866895002499	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895002500	homodimer interface [polypeptide binding]; other site
866895002501	catalytic residue [active]
866895002502	thiamine pyrophosphate protein; Validated; Region: PRK08199
866895002503	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
866895002504	PYR/PP interface [polypeptide binding]; other site
866895002505	dimer interface [polypeptide binding]; other site
866895002506	TPP binding site [chemical binding]; other site
866895002507	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866895002508	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
866895002509	TPP-binding site [chemical binding]; other site
866895002510	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
866895002511	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866895002512	NAD(P) binding site [chemical binding]; other site
866895002513	catalytic residues [active]
866895002514	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895002515	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
866895002516	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
866895002517	Nucleoside recognition; Region: Gate; pfam07670
866895002518	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
866895002519	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895002520	inhibitor-cofactor binding pocket; inhibition site
866895002521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895002522	catalytic residue [active]
866895002523	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
866895002524	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
866895002525	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
866895002526	classical (c) SDRs; Region: SDR_c; cd05233
866895002527	NAD(P) binding site [chemical binding]; other site
866895002528	active site
866895002529	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
866895002530	Acyltransferase family; Region: Acyl_transf_3; pfam01757
866895002531	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
866895002532	NAD synthase; Region: NAD_synthase; pfam02540
866895002533	homodimer interface [polypeptide binding]; other site
866895002534	NAD binding pocket [chemical binding]; other site
866895002535	ATP binding pocket [chemical binding]; other site
866895002536	Mg binding site [ion binding]; other site
866895002537	active-site loop [active]
866895002538	Isochorismatase family; Region: Isochorismatase; pfam00857
866895002539	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
866895002540	catalytic triad [active]
866895002541	conserved cis-peptide bond; other site
866895002542	MutS domain III; Region: MutS_III; pfam05192
866895002543	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
866895002544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895002545	Walker A/P-loop; other site
866895002546	ATP binding site [chemical binding]; other site
866895002547	Q-loop/lid; other site
866895002548	ABC transporter signature motif; other site
866895002549	Walker B; other site
866895002550	D-loop; other site
866895002551	H-loop/switch region; other site
866895002552	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
866895002553	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
866895002554	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895002555	PAS domain; Region: PAS_9; pfam13426
866895002556	putative active site [active]
866895002557	heme pocket [chemical binding]; other site
866895002558	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895002559	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
866895002560	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
866895002561	active site
866895002562	FMN binding site [chemical binding]; other site
866895002563	substrate binding site [chemical binding]; other site
866895002564	putative catalytic residue [active]
866895002565	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
866895002566	Part of AAA domain; Region: AAA_19; pfam13245
866895002567	Family description; Region: UvrD_C_2; pfam13538
866895002568	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866895002569	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866895002570	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
866895002571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895002572	Coenzyme A binding pocket [chemical binding]; other site
866895002573	hypothetical protein; Provisional; Region: PRK06770
866895002574	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
866895002575	classical (c) SDRs; Region: SDR_c; cd05233
866895002576	NAD(P) binding site [chemical binding]; other site
866895002577	active site
866895002578	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
866895002579	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866895002580	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866895002581	Walker A/P-loop; other site
866895002582	ATP binding site [chemical binding]; other site
866895002583	Q-loop/lid; other site
866895002584	ABC transporter signature motif; other site
866895002585	Walker B; other site
866895002586	D-loop; other site
866895002587	H-loop/switch region; other site
866895002588	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
866895002589	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
866895002590	hypothetical protein; Provisional; Region: PRK00967
866895002591	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
866895002592	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895002593	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895002594	DNA binding residues [nucleotide binding]
866895002595	anthranilate synthase component I; Provisional; Region: PRK13569
866895002596	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
866895002597	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
866895002598	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
866895002599	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
866895002600	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
866895002601	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
866895002602	active site
866895002603	ribulose/triose binding site [chemical binding]; other site
866895002604	phosphate binding site [ion binding]; other site
866895002605	substrate (anthranilate) binding pocket [chemical binding]; other site
866895002606	product (indole) binding pocket [chemical binding]; other site
866895002607	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
866895002608	active site
866895002609	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
866895002610	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
866895002611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895002612	catalytic residue [active]
866895002613	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
866895002614	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
866895002615	substrate binding site [chemical binding]; other site
866895002616	active site
866895002617	catalytic residues [active]
866895002618	heterodimer interface [polypeptide binding]; other site
866895002619	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
866895002620	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
866895002621	glutamine binding [chemical binding]; other site
866895002622	catalytic triad [active]
866895002623	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
866895002624	Na binding site [ion binding]; other site
866895002625	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895002626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895002627	active site
866895002628	phosphorylation site [posttranslational modification]
866895002629	intermolecular recognition site; other site
866895002630	dimerization interface [polypeptide binding]; other site
866895002631	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895002632	DNA binding residues [nucleotide binding]
866895002633	dimerization interface [polypeptide binding]; other site
866895002634	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
866895002635	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
866895002636	Catalytic site [active]
866895002637	Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389
866895002638	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
866895002639	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
866895002640	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
866895002641	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
866895002642	active site
866895002643	Zn binding site [ion binding]; other site
866895002644	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
866895002645	dimanganese center [ion binding]; other site
866895002646	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
866895002647	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
866895002648	inhibitor binding site; inhibition site
866895002649	active site
866895002650	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
866895002651	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
866895002652	non-specific DNA interactions [nucleotide binding]; other site
866895002653	DNA binding site [nucleotide binding]
866895002654	sequence specific DNA binding site [nucleotide binding]; other site
866895002655	putative cAMP binding site [chemical binding]; other site
866895002656	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866895002657	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866895002658	nucleotide binding site [chemical binding]; other site
866895002659	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866895002660	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866895002661	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866895002662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
866895002663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895002664	dimer interface [polypeptide binding]; other site
866895002665	putative PBP binding loops; other site
866895002666	ABC-ATPase subunit interface; other site
866895002667	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866895002668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895002669	dimer interface [polypeptide binding]; other site
866895002670	conserved gate region; other site
866895002671	putative PBP binding loops; other site
866895002672	ABC-ATPase subunit interface; other site
866895002673	Protein of unknown function, DUF624; Region: DUF624; cl02369
866895002674	xylose isomerase; Provisional; Region: PRK05474
866895002675	xylose isomerase; Region: xylose_isom_A; TIGR02630
866895002676	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
866895002677	N- and C-terminal domain interface [polypeptide binding]; other site
866895002678	D-xylulose kinase; Region: XylB; TIGR01312
866895002679	active site
866895002680	MgATP binding site [chemical binding]; other site
866895002681	catalytic site [active]
866895002682	metal binding site [ion binding]; metal-binding site
866895002683	xylulose binding site [chemical binding]; other site
866895002684	homodimer interface [polypeptide binding]; other site
866895002685	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895002686	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895002687	active site
866895002688	catalytic tetrad [active]
866895002689	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
866895002690	active site
866895002691	catalytic residues [active]
866895002692	Chain length determinant protein; Region: Wzz; cl15801
866895002693	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
866895002694	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
866895002695	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
866895002696	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
866895002697	NAD(P) binding site [chemical binding]; other site
866895002698	homodimer interface [polypeptide binding]; other site
866895002699	substrate binding site [chemical binding]; other site
866895002700	active site
866895002701	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
866895002702	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895002703	putative ADP-binding pocket [chemical binding]; other site
866895002704	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895002705	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
866895002706	putative ADP-binding pocket [chemical binding]; other site
866895002707	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
866895002708	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866895002709	active site
866895002710	UDP-glucose 4-epimerase; Region: PLN02240
866895002711	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
866895002712	NAD binding site [chemical binding]; other site
866895002713	homodimer interface [polypeptide binding]; other site
866895002714	active site
866895002715	substrate binding site [chemical binding]; other site
866895002716	Bacterial sugar transferase; Region: Bac_transf; pfam02397
866895002717	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
866895002718	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
866895002719	putative trimer interface [polypeptide binding]; other site
866895002720	putative CoA binding site [chemical binding]; other site
866895002721	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
866895002722	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
866895002723	inhibitor-cofactor binding pocket; inhibition site
866895002724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895002725	catalytic residue [active]
866895002726	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866895002727	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895002728	non-specific DNA binding site [nucleotide binding]; other site
866895002729	salt bridge; other site
866895002730	sequence-specific DNA binding site [nucleotide binding]; other site
866895002731	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895002732	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
866895002733	putative ADP-binding pocket [chemical binding]; other site
866895002734	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895002735	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
866895002736	putative ADP-binding pocket [chemical binding]; other site
866895002737	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
866895002738	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866895002739	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
866895002740	Predicted integral membrane protein [Function unknown]; Region: COG5542
866895002741	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
866895002742	active site
866895002743	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
866895002744	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895002745	motif II; other site
866895002746	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
866895002747	Uncharacterized conserved protein [Function unknown]; Region: COG3347
866895002748	intersubunit interface [polypeptide binding]; other site
866895002749	active site
866895002750	Zn2+ binding site [ion binding]; other site
866895002751	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
866895002752	Ligand binding site; other site
866895002753	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866895002754	active site
866895002755	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
866895002756	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
866895002757	Ligand binding site; other site
866895002758	Putative Catalytic site; other site
866895002759	DXD motif; other site
866895002760	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584
866895002761	putative active site [active]
866895002762	catalytic site [active]
866895002764	SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249
866895002765	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
866895002766	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
866895002767	Catalytic site [active]
866895002768	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866895002769	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895002770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895002771	Walker A/P-loop; other site
866895002772	ATP binding site [chemical binding]; other site
866895002773	Q-loop/lid; other site
866895002774	ABC transporter signature motif; other site
866895002775	Walker B; other site
866895002776	D-loop; other site
866895002777	H-loop/switch region; other site
866895002778	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
866895002779	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866895002780	active site
866895002781	metal binding site [ion binding]; metal-binding site
866895002782	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
866895002783	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
866895002784	putative active site [active]
866895002785	putative NTP binding site [chemical binding]; other site
866895002786	putative nucleic acid binding site [nucleotide binding]; other site
866895002787	short chain dehydrogenase; Provisional; Region: PRK09291
866895002788	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
866895002789	NADP binding site [chemical binding]; other site
866895002790	active site
866895002791	steroid binding site; other site
866895002792	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
866895002793	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
866895002794	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
866895002795	acyl-activating enzyme (AAE) consensus motif; other site
866895002796	putative active site [active]
866895002797	AMP binding site [chemical binding]; other site
866895002798	putative CoA binding site [chemical binding]; other site
866895002799	thioester reductase domain; Region: Thioester-redct; TIGR01746
866895002800	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
866895002801	putative NAD(P) binding site [chemical binding]; other site
866895002802	active site
866895002803	putative substrate binding site [chemical binding]; other site
866895002804	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866895002805	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866895002806	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
866895002807	Sodium Bile acid symporter family; Region: SBF; cl17470
866895002808	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
866895002809	active site
866895002810	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
866895002811	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
866895002812	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866895002813	FeS/SAM binding site; other site
866895002814	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
866895002815	active site
866895002816	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
866895002817	Ligand Binding Site [chemical binding]; other site
866895002818	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
866895002819	L-lactate permease; Region: Lactate_perm; cl00701
866895002820	argininosuccinate synthase; Provisional; Region: PRK13820
866895002821	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
866895002822	ANP binding site [chemical binding]; other site
866895002823	Substrate Binding Site II [chemical binding]; other site
866895002824	Substrate Binding Site I [chemical binding]; other site
866895002825	argininosuccinate lyase; Provisional; Region: PRK00855
866895002826	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
866895002827	active sites [active]
866895002828	tetramer interface [polypeptide binding]; other site
866895002829	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
866895002830	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895002831	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
866895002832	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895002833	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
866895002834	putative active site [active]
866895002835	Zn binding site [ion binding]; other site
866895002836	peroxiredoxin; Provisional; Region: PRK13189
866895002837	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
866895002838	dimer interface [polypeptide binding]; other site
866895002839	decamer (pentamer of dimers) interface [polypeptide binding]; other site
866895002840	catalytic triad [active]
866895002841	helicase 45; Provisional; Region: PTZ00424
866895002842	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866895002843	ATP binding site [chemical binding]; other site
866895002844	Mg++ binding site [ion binding]; other site
866895002845	motif III; other site
866895002846	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895002847	nucleotide binding region [chemical binding]; other site
866895002848	ATP-binding site [chemical binding]; other site
866895002849	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866895002850	Methyltransferase domain; Region: Methyltransf_12; pfam08242
866895002851	S-ribosylhomocysteinase; Provisional; Region: PRK02260
866895002852	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
866895002853	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
866895002854	dimer interface [polypeptide binding]; other site
866895002855	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895002856	catalytic residue [active]
866895002857	cystathionine beta-lyase; Provisional; Region: PRK07671
866895002858	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866895002859	homodimer interface [polypeptide binding]; other site
866895002860	substrate-cofactor binding pocket; other site
866895002861	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895002862	catalytic residue [active]
866895002863	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
866895002864	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
866895002865	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
866895002866	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
866895002867	Walker A/P-loop; other site
866895002868	ATP binding site [chemical binding]; other site
866895002869	Q-loop/lid; other site
866895002870	ABC transporter signature motif; other site
866895002871	Walker B; other site
866895002872	D-loop; other site
866895002873	H-loop/switch region; other site
866895002874	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
866895002875	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895002876	dimer interface [polypeptide binding]; other site
866895002877	conserved gate region; other site
866895002878	putative PBP binding loops; other site
866895002879	ABC-ATPase subunit interface; other site
866895002880	NMT1-like family; Region: NMT1_2; pfam13379
866895002881	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
866895002882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
866895002883	PAS domain; Region: PAS_9; pfam13426
866895002884	putative active site [active]
866895002885	heme pocket [chemical binding]; other site
866895002886	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
866895002887	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895002888	Walker A motif; other site
866895002889	ATP binding site [chemical binding]; other site
866895002890	Walker B motif; other site
866895002891	arginine finger; other site
866895002892	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
866895002893	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
866895002894	Coenzyme A transferase; Region: CoA_trans; cl17247
866895002895	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
866895002896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895002897	NAD(P) binding site [chemical binding]; other site
866895002898	active site
866895002899	putative acyltransferase; Provisional; Region: PRK05790
866895002900	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866895002901	dimer interface [polypeptide binding]; other site
866895002902	active site
866895002903	Citrate transporter; Region: CitMHS; pfam03600
866895002904	fructuronate transporter; Provisional; Region: PRK10034; cl15264
866895002905	Predicted acetyltransferase [General function prediction only]; Region: COG3393
866895002906	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895002907	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
866895002908	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
866895002909	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895002910	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
866895002911	active site
866895002912	putative catalytic site [active]
866895002913	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
866895002914	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
866895002915	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
866895002916	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
866895002917	active site
866895002918	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
866895002919	TIGR01777 family protein; Region: yfcH
866895002920	putative NAD(P) binding site [chemical binding]; other site
866895002921	putative active site [active]
866895002922	RecX family; Region: RecX; cl00936
866895002923	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895002924	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895002925	Probable transposase; Region: OrfB_IS605; pfam01385
866895002926	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895002927	NIPSNAP; Region: NIPSNAP; pfam07978
866895002928	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
866895002929	nudix motif; other site
866895002930	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895002931	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866895002932	active site
866895002933	motif I; other site
866895002934	motif II; other site
866895002935	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866895002936	CAT RNA binding domain; Region: CAT_RBD; smart01061
866895002937	transcriptional antiterminator BglG; Provisional; Region: PRK09772
866895002938	PRD domain; Region: PRD; pfam00874
866895002939	PRD domain; Region: PRD; pfam00874
866895002940	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866895002941	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
866895002942	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866895002943	active site turn [active]
866895002944	phosphorylation site [posttranslational modification]
866895002945	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
866895002946	HPr interaction site; other site
866895002947	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866895002948	active site
866895002949	phosphorylation site [posttranslational modification]
866895002950	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866895002951	regulatory protein interface [polypeptide binding]; other site
866895002952	active site
866895002953	regulatory phosphorylation site [posttranslational modification]; other site
866895002954	short chain dehydrogenase; Provisional; Region: PRK06924
866895002955	classical (c) SDRs; Region: SDR_c; cd05233
866895002956	NAD(P) binding site [chemical binding]; other site
866895002957	active site
866895002958	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
866895002959	WVELL protein; Region: WVELL; pfam14043
866895002960	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
866895002961	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
866895002962	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866895002963	minor groove reading motif; other site
866895002964	helix-hairpin-helix signature motif; other site
866895002965	substrate binding pocket [chemical binding]; other site
866895002966	active site
866895002967	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
866895002968	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
866895002969	DNA binding and oxoG recognition site [nucleotide binding]
866895002970	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895002971	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895002972	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866895002973	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895002974	hypothetical protein; Provisional; Region: PRK13662
866895002975	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866895002976	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895002977	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
866895002978	Walker A/P-loop; other site
866895002979	ATP binding site [chemical binding]; other site
866895002980	Q-loop/lid; other site
866895002981	ABC transporter signature motif; other site
866895002982	Walker B; other site
866895002983	D-loop; other site
866895002984	H-loop/switch region; other site
866895002985	Predicted membrane protein [Function unknown]; Region: COG4129
866895002986	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
866895002987	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
866895002988	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895002989	inhibitor-cofactor binding pocket; inhibition site
866895002990	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895002991	catalytic residue [active]
866895002992	Ion channel; Region: Ion_trans_2; pfam07885
866895002993	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
866895002994	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
866895002995	catalytic triad [active]
866895002996	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
866895002997	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
866895002998	NAD binding site [chemical binding]; other site
866895002999	ligand binding site [chemical binding]; other site
866895003000	catalytic site [active]
866895003001	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
866895003002	ferric uptake regulator; Provisional; Region: fur; PRK09462
866895003003	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
866895003004	metal binding site 2 [ion binding]; metal-binding site
866895003005	putative DNA binding helix; other site
866895003006	metal binding site 1 [ion binding]; metal-binding site
866895003007	dimer interface [polypeptide binding]; other site
866895003008	structural Zn2+ binding site [ion binding]; other site
866895003009	Protein of unknown function (DUF2614); Region: DUF2614; pfam11023
866895003010	Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250
866895003011	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
866895003012	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
866895003013	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
866895003014	active site
866895003015	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
866895003016	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
866895003017	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
866895003018	EamA-like transporter family; Region: EamA; pfam00892
866895003019	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
866895003020	epoxyqueuosine reductase; Region: TIGR00276
866895003021	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
866895003022	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
866895003023	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
866895003024	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
866895003025	DNA binding site [nucleotide binding]
866895003026	active site
866895003027	Putative amidase domain; Region: Amidase_6; pfam12671
866895003028	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
866895003029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866895003030	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
866895003031	Helix-turn-helix domain; Region: HTH_28; pfam13518
866895003032	putative transposase OrfB; Reviewed; Region: PHA02517
866895003033	HTH-like domain; Region: HTH_21; pfam13276
866895003034	Integrase core domain; Region: rve; pfam00665
866895003035	Integrase core domain; Region: rve_2; pfam13333
866895003036	lipoyl synthase; Provisional; Region: PRK05481
866895003037	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866895003038	FeS/SAM binding site; other site
866895003039	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
866895003040	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
866895003041	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
866895003042	exopolyphosphatase; Region: exo_poly_only; TIGR03706
866895003043	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
866895003044	polyphosphate kinase; Provisional; Region: PRK05443
866895003045	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
866895003046	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
866895003047	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
866895003048	putative domain interface [polypeptide binding]; other site
866895003049	putative active site [active]
866895003050	catalytic site [active]
866895003051	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
866895003052	putative domain interface [polypeptide binding]; other site
866895003053	putative active site [active]
866895003054	catalytic site [active]
866895003055	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
866895003056	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
866895003057	TPP-binding site [chemical binding]; other site
866895003058	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
866895003059	dimer interface [polypeptide binding]; other site
866895003060	PYR/PP interface [polypeptide binding]; other site
866895003061	TPP binding site [chemical binding]; other site
866895003062	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866895003063	E3 interaction surface; other site
866895003064	lipoyl attachment site [posttranslational modification]; other site
866895003065	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
866895003066	e3 binding domain; Region: E3_binding; pfam02817
866895003067	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
866895003068	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
866895003069	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
866895003070	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
866895003071	Part of AAA domain; Region: AAA_19; pfam13245
866895003072	Family description; Region: UvrD_C_2; pfam13538
866895003073	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
866895003074	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
866895003075	TrkA-C domain; Region: TrkA_C; pfam02080
866895003076	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
866895003077	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
866895003078	Uncharacterized conserved protein [Function unknown]; Region: COG3402
866895003079	Predicted membrane protein [Function unknown]; Region: COG3428
866895003080	Bacterial PH domain; Region: DUF304; pfam03703
866895003081	Bacterial PH domain; Region: DUF304; pfam03703
866895003082	Bacterial PH domain; Region: DUF304; pfam03703
866895003083	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
866895003084	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
866895003085	Spore germination protein; Region: Spore_permease; cl17796
866895003086	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
866895003087	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
866895003088	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895003089	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
866895003090	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
866895003091	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
866895003092	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
866895003093	Nucleoside recognition; Region: Gate; pfam07670
866895003094	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
866895003095	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866895003096	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
866895003097	NAD(P) binding site [chemical binding]; other site
866895003098	catalytic residues [active]
866895003099	multidrug efflux protein; Reviewed; Region: PRK01766
866895003100	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
866895003101	cation binding site [ion binding]; other site
866895003102	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
866895003103	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
866895003104	active site
866895003105	homodimer interface [polypeptide binding]; other site
866895003106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
866895003107	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
866895003108	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
866895003109	Part of AAA domain; Region: AAA_19; pfam13245
866895003110	Family description; Region: UvrD_C_2; pfam13538
866895003111	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895003112	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895003113	active site
866895003114	catalytic tetrad [active]
866895003115	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
866895003116	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
866895003117	Spore germination protein; Region: Spore_permease; cl17796
866895003118	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
866895003119	Domain of unknown function (DUF389); Region: DUF389; cl00781
866895003120	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895003121	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
866895003122	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895003123	Walker A/P-loop; other site
866895003124	ATP binding site [chemical binding]; other site
866895003125	Q-loop/lid; other site
866895003126	ABC transporter signature motif; other site
866895003127	Walker B; other site
866895003128	D-loop; other site
866895003129	H-loop/switch region; other site
866895003130	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866895003131	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895003132	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
866895003133	Walker A/P-loop; other site
866895003134	ATP binding site [chemical binding]; other site
866895003135	Q-loop/lid; other site
866895003136	ABC transporter signature motif; other site
866895003137	Walker B; other site
866895003138	D-loop; other site
866895003139	H-loop/switch region; other site
866895003140	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
866895003141	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
866895003142	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
866895003143	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866895003144	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
866895003145	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895003146	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
866895003147	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
866895003148	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
866895003149	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895003150	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866895003151	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
866895003152	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895003153	Coenzyme A binding pocket [chemical binding]; other site
866895003154	Predicted amidohydrolase [General function prediction only]; Region: COG0388
866895003155	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
866895003156	putative active site [active]
866895003157	catalytic triad [active]
866895003158	putative dimer interface [polypeptide binding]; other site
866895003159	short chain dehydrogenase; Provisional; Region: PRK07326
866895003160	classical (c) SDRs; Region: SDR_c; cd05233
866895003161	NAD(P) binding site [chemical binding]; other site
866895003162	active site
866895003163	YhdB-like protein; Region: YhdB; pfam14148
866895003164	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
866895003165	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
866895003166	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895003167	Coenzyme A binding pocket [chemical binding]; other site
866895003168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895003169	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
866895003170	SpoVR like protein; Region: SpoVR; pfam04293
866895003171	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
866895003172	putative nucleotide binding site [chemical binding]; other site
866895003173	uridine monophosphate binding site [chemical binding]; other site
866895003174	homohexameric interface [polypeptide binding]; other site
866895003175	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
866895003176	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
866895003177	homodimer interface [polypeptide binding]; other site
866895003178	substrate-cofactor binding pocket; other site
866895003179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895003180	catalytic residue [active]
866895003181	Predicted membrane protein [Function unknown]; Region: COG2364
866895003182	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
866895003183	short chain dehydrogenase; Provisional; Region: PRK06924
866895003184	sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367
866895003185	NADP binding site [chemical binding]; other site
866895003186	homodimer interface [polypeptide binding]; other site
866895003187	active site
866895003188	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
866895003189	putative dimer interface [polypeptide binding]; other site
866895003190	catalytic triad [active]
866895003191	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
866895003192	RibD C-terminal domain; Region: RibD_C; cl17279
866895003193	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
866895003194	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895003195	ABC transporter; Region: ABC_tran_2; pfam12848
866895003196	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866895003197	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895003198	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
866895003199	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
866895003200	EamA-like transporter family; Region: EamA; cl17759
866895003201	EamA-like transporter family; Region: EamA; pfam00892
866895003202	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866895003203	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866895003204	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
866895003205	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
866895003206	Sulfate transporter family; Region: Sulfate_transp; pfam00916
866895003207	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
866895003208	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866895003209	Ligand Binding Site [chemical binding]; other site
866895003210	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
866895003211	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
866895003212	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866895003213	Walker A/P-loop; other site
866895003214	ATP binding site [chemical binding]; other site
866895003215	Q-loop/lid; other site
866895003216	ABC transporter signature motif; other site
866895003217	Walker B; other site
866895003218	D-loop; other site
866895003219	H-loop/switch region; other site
866895003220	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
866895003221	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895003222	Coenzyme A binding pocket [chemical binding]; other site
866895003223	maltose O-acetyltransferase; Provisional; Region: PRK10092
866895003224	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
866895003225	active site
866895003226	substrate binding site [chemical binding]; other site
866895003227	trimer interface [polypeptide binding]; other site
866895003228	CoA binding site [chemical binding]; other site
866895003229	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
866895003230	active site
866895003231	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866895003232	DNA-binding site [nucleotide binding]; DNA binding site
866895003233	RNA-binding motif; other site
866895003234	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866895003235	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
866895003236	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
866895003237	cobalamin binding residues [chemical binding]; other site
866895003238	putative BtuC binding residues; other site
866895003239	dimer interface [polypeptide binding]; other site
866895003240	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866895003241	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
866895003242	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
866895003243	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
866895003244	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895003245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895003246	Coenzyme A binding pocket [chemical binding]; other site
866895003247	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
866895003248	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
866895003249	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
866895003250	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866895003251	IDEAL domain; Region: IDEAL; pfam08858
866895003252	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
866895003253	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
866895003254	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
866895003255	NADH(P)-binding; Region: NAD_binding_10; pfam13460
866895003256	NAD binding site [chemical binding]; other site
866895003257	substrate binding site [chemical binding]; other site
866895003258	putative active site [active]
866895003259	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
866895003260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895003261	putative substrate translocation pore; other site
866895003262	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
866895003263	fumarate hydratase; Reviewed; Region: fumC; PRK00485
866895003264	Class II fumarases; Region: Fumarase_classII; cd01362
866895003265	active site
866895003266	tetramer interface [polypeptide binding]; other site
866895003267	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
866895003268	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
866895003269	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
866895003270	Walker A/P-loop; other site
866895003271	ATP binding site [chemical binding]; other site
866895003272	Q-loop/lid; other site
866895003273	ABC transporter signature motif; other site
866895003274	Walker B; other site
866895003275	D-loop; other site
866895003276	H-loop/switch region; other site
866895003277	TOBE domain; Region: TOBE; pfam03459
866895003278	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
866895003279	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
866895003280	putative homodimer interface [polypeptide binding]; other site
866895003281	putative homotetramer interface [polypeptide binding]; other site
866895003282	putative metal binding site [ion binding]; other site
866895003283	putative homodimer-homodimer interface [polypeptide binding]; other site
866895003284	putative allosteric switch controlling residues; other site
866895003285	Protein of unknown function (DUF445); Region: DUF445; pfam04286
866895003286	hypothetical protein; Provisional; Region: PRK13676
866895003287	enoyl-CoA hydratase; Provisional; Region: PRK07659
866895003288	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866895003289	substrate binding site [chemical binding]; other site
866895003290	oxyanion hole (OAH) forming residues; other site
866895003291	trimer interface [polypeptide binding]; other site
866895003292	YhzD-like protein; Region: YhzD; pfam14120
866895003293	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
866895003294	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
866895003295	Walker A/P-loop; other site
866895003296	ATP binding site [chemical binding]; other site
866895003297	Q-loop/lid; other site
866895003298	ABC transporter signature motif; other site
866895003299	Walker B; other site
866895003300	D-loop; other site
866895003301	H-loop/switch region; other site
866895003302	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
866895003303	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
866895003304	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
866895003305	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
866895003306	active site
866895003307	metal binding site [ion binding]; metal-binding site
866895003308	DNA binding site [nucleotide binding]
866895003309	Uncharacterized conserved protein [Function unknown]; Region: COG4717
866895003310	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895003311	Walker A/P-loop; other site
866895003312	ATP binding site [chemical binding]; other site
866895003313	Predicted transcriptional regulators [Transcription]; Region: COG1510
866895003314	MarR family; Region: MarR_2; cl17246
866895003315	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
866895003316	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
866895003317	generic binding surface II; other site
866895003318	generic binding surface I; other site
866895003319	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866895003320	Zn2+ binding site [ion binding]; other site
866895003321	Mg2+ binding site [ion binding]; other site
866895003322	Transposase; Region: HTH_Tnp_1; cl17663
866895003323	putative transposase OrfB; Reviewed; Region: PHA02517
866895003324	HTH-like domain; Region: HTH_21; pfam13276
866895003325	Integrase core domain; Region: rve; pfam00665
866895003326	Integrase core domain; Region: rve_3; pfam13683
866895003327	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002
866895003328	SurA N-terminal domain; Region: SurA_N_3; cl07813
866895003329	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
866895003330	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
866895003331	transcriptional regulator Hpr; Provisional; Region: PRK13777
866895003332	MarR family; Region: MarR; pfam01047
866895003333	Predicted transcriptional regulators [Transcription]; Region: COG1510
866895003334	MarR family; Region: MarR_2; pfam12802
866895003335	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
866895003336	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
866895003337	Walker A/P-loop; other site
866895003338	ATP binding site [chemical binding]; other site
866895003339	Q-loop/lid; other site
866895003340	ABC transporter signature motif; other site
866895003341	Walker B; other site
866895003342	D-loop; other site
866895003343	H-loop/switch region; other site
866895003344	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
866895003345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895003346	dimer interface [polypeptide binding]; other site
866895003347	conserved gate region; other site
866895003348	putative PBP binding loops; other site
866895003349	ABC-ATPase subunit interface; other site
866895003350	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
866895003351	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
866895003352	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
866895003353	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
866895003354	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
866895003355	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
866895003356	HIT family signature motif; other site
866895003357	catalytic residue [active]
866895003358	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
866895003359	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866895003360	Walker A/P-loop; other site
866895003361	ATP binding site [chemical binding]; other site
866895003362	Q-loop/lid; other site
866895003363	ABC transporter signature motif; other site
866895003364	Walker B; other site
866895003365	D-loop; other site
866895003366	H-loop/switch region; other site
866895003367	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
866895003368	EcsC protein family; Region: EcsC; pfam12787
866895003369	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866895003370	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
866895003371	metal binding site [ion binding]; metal-binding site
866895003372	dimer interface [polypeptide binding]; other site
866895003373	Ferritin-like domain; Region: Ferritin; pfam00210
866895003374	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
866895003375	dinuclear metal binding motif [ion binding]; other site
866895003376	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
866895003377	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866895003378	Haemolysin-III related; Region: HlyIII; cl03831
866895003379	HAMP domain; Region: HAMP; pfam00672
866895003380	Histidine kinase; Region: HisKA_3; pfam07730
866895003381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895003382	ATP binding site [chemical binding]; other site
866895003383	Mg2+ binding site [ion binding]; other site
866895003384	G-X-G motif; other site
866895003385	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895003386	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895003387	active site
866895003388	phosphorylation site [posttranslational modification]
866895003389	intermolecular recognition site; other site
866895003390	dimerization interface [polypeptide binding]; other site
866895003391	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895003392	DNA binding residues [nucleotide binding]
866895003393	dimerization interface [polypeptide binding]; other site
866895003394	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
866895003395	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866895003396	catalytic residues [active]
866895003397	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
866895003398	Transglycosylase; Region: Transgly; pfam00912
866895003399	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
866895003400	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866895003401	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
866895003402	substrate binding site [chemical binding]; other site
866895003403	active site
866895003404	ferrochelatase; Provisional; Region: PRK12435
866895003405	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
866895003406	C-terminal domain interface [polypeptide binding]; other site
866895003407	active site
866895003408	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
866895003409	active site
866895003410	N-terminal domain interface [polypeptide binding]; other site
866895003411	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
866895003412	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895003413	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895003414	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895003415	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895003416	DNA binding site [nucleotide binding]
866895003417	domain linker motif; other site
866895003418	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
866895003419	putative dimerization interface [polypeptide binding]; other site
866895003420	putative ligand binding site [chemical binding]; other site
866895003421	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
866895003422	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
866895003423	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
866895003424	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
866895003425	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
866895003426	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
866895003427	acyl-activating enzyme (AAE) consensus motif; other site
866895003428	putative AMP binding site [chemical binding]; other site
866895003429	putative active site [active]
866895003430	putative CoA binding site [chemical binding]; other site
866895003431	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895003432	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895003433	Coenzyme A binding pocket [chemical binding]; other site
866895003434	Protein of unknown function (DUF3939); Region: DUF3939; pfam13075
866895003435	ComK protein; Region: ComK; cl11560
866895003436	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
866895003437	Uncharacterized conserved protein [Function unknown]; Region: COG0398
866895003438	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
866895003439	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
866895003440	Catalytic site [active]
866895003441	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
866895003442	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
866895003443	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
866895003444	Part of AAA domain; Region: AAA_19; pfam13245
866895003445	Family description; Region: UvrD_C_2; pfam13538
866895003446	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
866895003447	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
866895003448	active site
866895003449	Predicted membrane protein [Function unknown]; Region: COG2364
866895003450	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
866895003451	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
866895003452	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895003453	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895003454	Probable transposase; Region: OrfB_IS605; pfam01385
866895003455	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895003456	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895003457	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895003458	DNA binding site [nucleotide binding]
866895003459	domain linker motif; other site
866895003460	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
866895003461	dimerization interface [polypeptide binding]; other site
866895003462	ligand binding site [chemical binding]; other site
866895003463	sodium binding site [ion binding]; other site
866895003464	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
866895003465	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866895003466	active site turn [active]
866895003467	phosphorylation site [posttranslational modification]
866895003468	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866895003469	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
866895003470	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
866895003471	substrate binding [chemical binding]; other site
866895003472	active site
866895003473	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
866895003474	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
866895003475	Amidinotransferase; Region: Amidinotransf; pfam02274
866895003476	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
866895003477	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
866895003478	Spore germination protein GerPC; Region: GerPC; pfam10737
866895003479	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
866895003480	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
866895003481	Predicted membrane protein [Function unknown]; Region: COG2311
866895003482	Protein of unknown function (DUF418); Region: DUF418; cl12135
866895003483	Protein of unknown function (DUF418); Region: DUF418; pfam04235
866895003484	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
866895003485	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
866895003486	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
866895003487	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895003488	inhibitor-cofactor binding pocket; inhibition site
866895003489	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895003490	catalytic residue [active]
866895003491	hypothetical protein; Provisional; Region: PRK13673
866895003492	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
866895003493	active site
866895003494	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
866895003495	dimer interface [polypeptide binding]; other site
866895003496	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
866895003497	Ligand Binding Site [chemical binding]; other site
866895003498	Molecular Tunnel; other site
866895003499	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
866895003500	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
866895003501	active site
866895003502	catalytic site [active]
866895003503	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
866895003504	EDD domain protein, DegV family; Region: DegV; TIGR00762
866895003505	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
866895003506	Uncharacterized conserved protein [Function unknown]; Region: COG1284
866895003507	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
866895003508	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
866895003509	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
866895003510	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
866895003511	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
866895003512	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
866895003513	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866895003514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
866895003515	motif II; other site
866895003516	esterase; Provisional; Region: PRK10566
866895003517	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866895003518	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
866895003519	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866895003520	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
866895003521	MoaE homodimer interface [polypeptide binding]; other site
866895003522	MoaD interaction [polypeptide binding]; other site
866895003523	active site residues [active]
866895003524	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
866895003525	MoaE interaction surface [polypeptide binding]; other site
866895003526	MoeB interaction surface [polypeptide binding]; other site
866895003527	thiocarboxylated glycine; other site
866895003528	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
866895003529	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
866895003530	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
866895003531	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
866895003532	putative ligand binding site [chemical binding]; other site
866895003533	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
866895003534	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
866895003535	dimer interface [polypeptide binding]; other site
866895003536	active site
866895003537	CoA binding pocket [chemical binding]; other site
866895003538	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
866895003539	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
866895003540	dimer interface [polypeptide binding]; other site
866895003541	active site
866895003542	Transcriptional regulator [Transcription]; Region: LytR; COG1316
866895003543	Protein of unknown function (DUF3603); Region: DUF3603; pfam12227
866895003544	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
866895003545	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
866895003546	active site
866895003547	HIGH motif; other site
866895003548	dimer interface [polypeptide binding]; other site
866895003549	KMSKS motif; other site
866895003550	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
866895003551	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866895003552	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866895003553	peptide binding site [polypeptide binding]; other site
866895003554	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866895003555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895003556	dimer interface [polypeptide binding]; other site
866895003557	conserved gate region; other site
866895003558	putative PBP binding loops; other site
866895003559	ABC-ATPase subunit interface; other site
866895003560	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
866895003561	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
866895003562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895003563	dimer interface [polypeptide binding]; other site
866895003564	conserved gate region; other site
866895003565	putative PBP binding loops; other site
866895003566	ABC-ATPase subunit interface; other site
866895003567	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
866895003568	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866895003569	Walker A/P-loop; other site
866895003570	ATP binding site [chemical binding]; other site
866895003571	Q-loop/lid; other site
866895003572	ABC transporter signature motif; other site
866895003573	Walker B; other site
866895003574	D-loop; other site
866895003575	H-loop/switch region; other site
866895003576	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866895003577	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
866895003578	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866895003579	Walker A/P-loop; other site
866895003580	ATP binding site [chemical binding]; other site
866895003581	Q-loop/lid; other site
866895003582	ABC transporter signature motif; other site
866895003583	Walker B; other site
866895003584	D-loop; other site
866895003585	H-loop/switch region; other site
866895003586	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866895003587	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866895003588	Helix-turn-helix domain; Region: HTH_28; pfam13518
866895003589	putative transposase OrfB; Reviewed; Region: PHA02517
866895003590	HTH-like domain; Region: HTH_21; pfam13276
866895003591	Integrase core domain; Region: rve; pfam00665
866895003592	Integrase core domain; Region: rve_2; pfam13333
866895003593	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
866895003594	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
866895003595	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895003596	Coenzyme A binding pocket [chemical binding]; other site
866895003597	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
866895003598	ArsC family; Region: ArsC; pfam03960
866895003599	putative catalytic residues [active]
866895003600	thiol/disulfide switch; other site
866895003601	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
866895003602	adaptor protein; Provisional; Region: PRK02315
866895003603	Competence protein CoiA-like family; Region: CoiA; cl11541
866895003604	oligoendopeptidase F; Region: pepF; TIGR00181
866895003605	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
866895003606	active site
866895003607	Zn binding site [ion binding]; other site
866895003608	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
866895003609	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
866895003610	catalytic residues [active]
866895003611	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
866895003612	apolar tunnel; other site
866895003613	heme binding site [chemical binding]; other site
866895003614	dimerization interface [polypeptide binding]; other site
866895003615	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
866895003616	putative active site [active]
866895003617	putative metal binding residues [ion binding]; other site
866895003618	signature motif; other site
866895003619	putative triphosphate binding site [ion binding]; other site
866895003620	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
866895003621	synthetase active site [active]
866895003622	NTP binding site [chemical binding]; other site
866895003623	metal binding site [ion binding]; metal-binding site
866895003624	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
866895003625	ATP-NAD kinase; Region: NAD_kinase; pfam01513
866895003626	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866895003627	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866895003628	active site
866895003629	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
866895003630	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
866895003631	active site
866895003632	metal binding site [ion binding]; metal-binding site
866895003633	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
866895003634	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
866895003635	MgtE intracellular N domain; Region: MgtE_N; pfam03448
866895003636	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
866895003637	Divalent cation transporter; Region: MgtE; pfam01769
866895003638	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
866895003639	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
866895003640	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
866895003641	TrkA-N domain; Region: TrkA_N; pfam02254
866895003642	TrkA-C domain; Region: TrkA_C; pfam02080
866895003643	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
866895003644	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
866895003645	substrate binding pocket [chemical binding]; other site
866895003646	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866895003647	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
866895003648	active site
866895003649	Protein of unknown function (DUF2651); Region: DUF2651; pfam10852
866895003650	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
866895003651	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
866895003652	NAD binding site [chemical binding]; other site
866895003653	homotetramer interface [polypeptide binding]; other site
866895003654	homodimer interface [polypeptide binding]; other site
866895003655	substrate binding site [chemical binding]; other site
866895003656	active site
866895003657	Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153
866895003658	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
866895003659	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
866895003660	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
866895003661	Predicted membrane protein [Function unknown]; Region: COG2323
866895003662	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
866895003663	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895003664	Coenzyme A binding pocket [chemical binding]; other site
866895003665	hypothetical protein; Provisional; Region: PRK13679
866895003666	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
866895003667	Putative esterase; Region: Esterase; pfam00756
866895003668	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
866895003669	Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate...; Region: ZnMc_MMP; cd04278
866895003670	TIMP-binding surface; other site
866895003671	active site
866895003672	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
866895003673	EDD domain protein, DegV family; Region: DegV; TIGR00762
866895003674	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
866895003675	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895003676	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
866895003677	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
866895003678	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866895003679	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895003680	homodimer interface [polypeptide binding]; other site
866895003681	catalytic residue [active]
866895003682	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
866895003683	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
866895003684	TPP-binding site [chemical binding]; other site
866895003685	tetramer interface [polypeptide binding]; other site
866895003686	heterodimer interface [polypeptide binding]; other site
866895003687	phosphorylation loop region [posttranslational modification]
866895003688	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
866895003689	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
866895003690	alpha subunit interface [polypeptide binding]; other site
866895003691	TPP binding site [chemical binding]; other site
866895003692	heterodimer interface [polypeptide binding]; other site
866895003693	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866895003694	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866895003695	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
866895003696	E3 interaction surface; other site
866895003697	lipoyl attachment site [posttranslational modification]; other site
866895003698	e3 binding domain; Region: E3_binding; pfam02817
866895003699	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
866895003700	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
866895003701	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
866895003702	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
866895003703	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
866895003704	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
866895003705	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
866895003706	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
866895003707	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
866895003708	putative substrate binding pocket [chemical binding]; other site
866895003709	trimer interface [polypeptide binding]; other site
866895003710	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
866895003711	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
866895003712	Na binding site [ion binding]; other site
866895003713	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866895003714	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866895003715	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866895003716	dimerization interface [polypeptide binding]; other site
866895003717	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
866895003718	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
866895003719	NAD binding site [chemical binding]; other site
866895003720	catalytic residues [active]
866895003721	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
866895003722	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
866895003723	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
866895003724	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
866895003725	tetramer interface [polypeptide binding]; other site
866895003726	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
866895003727	tetramer interface [polypeptide binding]; other site
866895003728	active site
866895003729	metal binding site [ion binding]; metal-binding site
866895003730	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
866895003731	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
866895003732	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
866895003733	active site
866895003734	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
866895003735	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
866895003736	dimer interface [polypeptide binding]; other site
866895003737	active site
866895003738	catalytic residue [active]
866895003739	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239
866895003740	putative active site [active]
866895003741	Zn binding site [ion binding]; other site
866895003742	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
866895003743	active site
866895003744	Zn binding site [ion binding]; other site
866895003746	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
866895003747	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895003748	DNA-binding site [nucleotide binding]; DNA binding site
866895003749	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866895003750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895003751	homodimer interface [polypeptide binding]; other site
866895003752	catalytic residue [active]
866895003753	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
866895003754	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895003755	inhibitor-cofactor binding pocket; inhibition site
866895003756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895003757	catalytic residue [active]
866895003758	succinic semialdehyde dehydrogenase; Region: PLN02278
866895003759	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
866895003760	tetramerization interface [polypeptide binding]; other site
866895003761	NAD(P) binding site [chemical binding]; other site
866895003762	catalytic residues [active]
866895003763	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
866895003764	Na binding site [ion binding]; other site
866895003765	allantoate amidohydrolase; Reviewed; Region: PRK09290
866895003766	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
866895003767	active site
866895003768	metal binding site [ion binding]; metal-binding site
866895003769	dimer interface [polypeptide binding]; other site
866895003770	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
866895003771	acetylornithine deacetylase; Provisional; Region: PRK06837
866895003772	metal binding site [ion binding]; metal-binding site
866895003773	dimer interface [polypeptide binding]; other site
866895003774	FRG domain; Region: FRG; pfam08867
866895003775	ethanolamine permease; Region: 2A0305; TIGR00908
866895003776	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
866895003777	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
866895003778	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
866895003779	flagellin; Reviewed; Region: PRK08869
866895003780	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
866895003781	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
866895003782	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
866895003783	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
866895003784	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866895003785	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866895003786	metal binding site [ion binding]; metal-binding site
866895003787	active site
866895003788	I-site; other site
866895003789	malate:quinone oxidoreductase; Validated; Region: PRK05257
866895003790	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
866895003791	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
866895003792	L-lactate permease; Region: Lactate_perm; cl00701
866895003793	YjzC-like protein; Region: YjzC; pfam14168
866895003794	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
866895003795	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
866895003796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
866895003797	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
866895003798	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
866895003799	DHHA1 domain; Region: DHHA1; pfam02272
866895003800	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
866895003801	DNA topoisomerase III; Provisional; Region: PRK07726
866895003802	active site
866895003803	putative interdomain interaction site [polypeptide binding]; other site
866895003804	putative metal-binding site [ion binding]; other site
866895003805	putative nucleotide binding site [chemical binding]; other site
866895003806	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
866895003807	domain I; other site
866895003808	DNA binding groove [nucleotide binding]
866895003809	phosphate binding site [ion binding]; other site
866895003810	domain II; other site
866895003811	domain III; other site
866895003812	nucleotide binding site [chemical binding]; other site
866895003813	catalytic site [active]
866895003814	domain IV; other site
866895003815	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
866895003816	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
866895003817	Predicted integral membrane protein [Function unknown]; Region: COG5505
866895003818	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
866895003819	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
866895003820	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866895003821	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
866895003822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895003823	active site
866895003824	motif I; other site
866895003825	motif II; other site
866895003826	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
866895003827	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
866895003828	high affinity sulphate transporter 1; Region: sulP; TIGR00815
866895003829	Sulfate transporter family; Region: Sulfate_transp; pfam00916
866895003830	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
866895003831	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
866895003832	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
866895003833	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
866895003834	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
866895003835	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
866895003836	inhibitor-cofactor binding pocket; inhibition site
866895003837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895003838	catalytic residue [active]
866895003839	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866895003840	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895003841	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866895003842	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
866895003843	putative trimer interface [polypeptide binding]; other site
866895003844	putative CoA binding site [chemical binding]; other site
866895003845	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
866895003846	putative trimer interface [polypeptide binding]; other site
866895003847	putative active site [active]
866895003848	putative substrate binding site [chemical binding]; other site
866895003849	putative CoA binding site [chemical binding]; other site
866895003850	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
866895003851	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
866895003852	putative metal binding site; other site
866895003853	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895003854	binding surface
866895003855	TPR motif; other site
866895003856	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866895003857	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895003858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895003859	S-adenosylmethionine binding site [chemical binding]; other site
866895003860	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
866895003861	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
866895003862	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
866895003863	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866895003864	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
866895003865	Walker A/P-loop; other site
866895003866	ATP binding site [chemical binding]; other site
866895003867	Q-loop/lid; other site
866895003868	ABC transporter signature motif; other site
866895003869	Walker B; other site
866895003870	D-loop; other site
866895003871	H-loop/switch region; other site
866895003872	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
866895003873	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
866895003874	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895003875	motif II; other site
866895003876	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
866895003877	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
866895003878	ligand binding site [chemical binding]; other site
866895003879	flexible hinge region; other site
866895003880	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
866895003881	putative switch regulator; other site
866895003882	non-specific DNA interactions [nucleotide binding]; other site
866895003883	DNA binding site [nucleotide binding]
866895003884	sequence specific DNA binding site [nucleotide binding]; other site
866895003885	putative cAMP binding site [chemical binding]; other site
866895003886	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
866895003887	Sulfatase; Region: Sulfatase; pfam00884
866895003888	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866895003889	Ligand Binding Site [chemical binding]; other site
866895003890	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
866895003891	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
866895003892	Sulfate transporter family; Region: Sulfate_transp; pfam00916
866895003893	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
866895003894	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866895003895	Ligand Binding Site [chemical binding]; other site
866895003896	Helix-turn-helix domain; Region: HTH_17; pfam12728
866895003897	Uncharacterized conserved protein [Function unknown]; Region: COG0398
866895003898	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
866895003899	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
866895003900	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
866895003901	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
866895003902	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
866895003903	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
866895003904	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
866895003905	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
866895003906	ligand binding site [chemical binding]; other site
866895003907	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
866895003908	pyruvate phosphate dikinase; Provisional; Region: PRK09279
866895003909	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
866895003910	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
866895003911	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
866895003912	PEP synthetase regulatory protein; Provisional; Region: PRK05339
866895003913	6-phosphofructokinase; Provisional; Region: PRK03202
866895003914	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
866895003915	active site
866895003916	ADP/pyrophosphate binding site [chemical binding]; other site
866895003917	dimerization interface [polypeptide binding]; other site
866895003918	allosteric effector site; other site
866895003919	fructose-1,6-bisphosphate binding site; other site
866895003920	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
866895003921	putative lipoprotein, rSAM/lipoprotein system; Region: lipo_with_rSAM; TIGR04134
866895003922	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
866895003923	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
866895003924	intersubunit interface [polypeptide binding]; other site
866895003925	YodA lipocalin-like domain; Region: YodA; pfam09223
866895003926	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
866895003927	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
866895003928	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
866895003929	CopC domain; Region: CopC; pfam04234
866895003930	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
866895003931	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
866895003932	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
866895003933	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
866895003934	Bacterial Ig-like domain 2; Region: BID_2; smart00635
866895003935	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
866895003936	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
866895003937	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
866895003938	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
866895003939	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
866895003940	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
866895003941	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866895003942	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866895003943	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
866895003944	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
866895003945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895003946	dimer interface [polypeptide binding]; other site
866895003947	conserved gate region; other site
866895003948	putative PBP binding loops; other site
866895003949	ABC-ATPase subunit interface; other site
866895003950	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866895003951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895003952	dimer interface [polypeptide binding]; other site
866895003953	conserved gate region; other site
866895003954	putative PBP binding loops; other site
866895003955	ABC-ATPase subunit interface; other site
866895003956	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
866895003957	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
866895003958	Ca binding site [ion binding]; other site
866895003959	active site
866895003960	catalytic site [active]
866895003961	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895003962	Coenzyme A binding pocket [chemical binding]; other site
866895003963	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
866895003964	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
866895003965	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
866895003966	putative active site [active]
866895003967	putative NTP binding site [chemical binding]; other site
866895003968	putative nucleic acid binding site [nucleotide binding]; other site
866895003969	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
866895003970	active site
866895003971	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
866895003972	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
866895003973	putative active site [active]
866895003974	putative NTP binding site [chemical binding]; other site
866895003975	putative nucleic acid binding site [nucleotide binding]; other site
866895003976	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
866895003977	active site
866895003978	P-type ATPase of unknown pump specificity (type V); Region: P-ATPase-V; TIGR01657
866895003979	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
866895003980	RDD family; Region: RDD; pfam06271
866895003981	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
866895003982	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
866895003983	putative active site [active]
866895003984	putative NTP binding site [chemical binding]; other site
866895003985	putative nucleic acid binding site [nucleotide binding]; other site
866895003986	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
866895003987	active site
866895003988	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
866895003989	Protein of unknown function (DUF1569); Region: DUF1569; pfam07606
866895003990	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866895003991	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
866895003992	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
866895003993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895003994	S-adenosylmethionine binding site [chemical binding]; other site
866895003995	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866895003996	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
866895003997	hypothetical protein; Provisional; Region: PRK08244
866895003998	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
866895003999	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
866895004000	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
866895004001	Predicted membrane protein [Function unknown]; Region: COG2323
866895004002	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
866895004003	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
866895004004	YjzC-like protein; Region: YjzC; pfam14168
866895004005	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
866895004006	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866895004007	putative active site [active]
866895004008	putative metal binding site [ion binding]; other site
866895004009	RDD family; Region: RDD; pfam06271
866895004010	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
866895004011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895004012	ATP-grasp domain; Region: ATP-grasp; pfam02222
866895004013	Helix-turn-helix domain; Region: HTH_36; pfam13730
866895004014	EamA-like transporter family; Region: EamA; pfam00892
866895004015	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
866895004016	EamA-like transporter family; Region: EamA; pfam00892
866895004017	Protein of unknown function, DUF488; Region: DUF488; pfam04343
866895004018	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
866895004019	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866895004020	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866895004021	catalytic residue [active]
866895004022	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
866895004023	short chain dehydrogenase; Provisional; Region: PRK06701
866895004024	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
866895004025	NAD binding site [chemical binding]; other site
866895004026	metal binding site [ion binding]; metal-binding site
866895004027	active site
866895004028	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
866895004029	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
866895004030	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
866895004031	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866895004032	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
866895004033	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866895004034	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895004035	putative transporter; Provisional; Region: PRK10484
866895004036	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
866895004037	Na binding site [ion binding]; other site
866895004038	OsmC-like protein; Region: OsmC; pfam02566
866895004039	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
866895004040	EamA-like transporter family; Region: EamA; pfam00892
866895004041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
866895004042	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
866895004043	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866895004044	dimer interface [polypeptide binding]; other site
866895004045	putative CheW interface [polypeptide binding]; other site
866895004046	Predicted membrane protein [Function unknown]; Region: COG3601
866895004047	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
866895004048	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
866895004049	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
866895004050	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
866895004051	homodimer interface [polypeptide binding]; other site
866895004052	substrate-cofactor binding pocket; other site
866895004053	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895004054	catalytic residue [active]
866895004055	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
866895004056	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
866895004057	PYR/PP interface [polypeptide binding]; other site
866895004058	dimer interface [polypeptide binding]; other site
866895004059	TPP binding site [chemical binding]; other site
866895004060	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866895004061	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
866895004062	TPP-binding site [chemical binding]; other site
866895004063	dimer interface [polypeptide binding]; other site
866895004064	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
866895004065	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
866895004066	putative valine binding site [chemical binding]; other site
866895004067	dimer interface [polypeptide binding]; other site
866895004068	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
866895004069	ketol-acid reductoisomerase; Provisional; Region: PRK05479
866895004070	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
866895004071	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
866895004072	2-isopropylmalate synthase; Validated; Region: PRK00915
866895004073	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
866895004074	active site
866895004075	catalytic residues [active]
866895004076	metal binding site [ion binding]; metal-binding site
866895004077	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
866895004078	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
866895004079	tartrate dehydrogenase; Provisional; Region: PRK08194
866895004080	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
866895004081	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
866895004082	substrate binding site [chemical binding]; other site
866895004083	ligand binding site [chemical binding]; other site
866895004084	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
866895004085	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
866895004086	substrate binding site [chemical binding]; other site
866895004087	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
866895004088	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
866895004089	tetramer interface [polypeptide binding]; other site
866895004090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895004091	catalytic residue [active]
866895004092	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
866895004093	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
866895004094	siderophore binding site; other site
866895004095	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866895004096	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866895004097	ABC-ATPase subunit  interface; other site
866895004098	dimer interface [polypeptide binding]; other site
866895004099	putative PBP binding regions; other site
866895004100	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866895004101	ABC-ATPase subunit  interface; other site
866895004102	dimer interface [polypeptide binding]; other site
866895004103	putative PBP binding regions; other site
866895004104	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
866895004105	hypothetical protein; Provisional; Region: PRK06184
866895004106	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866895004107	MarR family; Region: MarR; pfam01047
866895004108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895004109	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895004110	putative substrate translocation pore; other site
866895004111	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
866895004112	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
866895004113	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
866895004114	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
866895004115	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
866895004116	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
866895004117	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895004118	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895004119	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
866895004120	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895004121	salt bridge; other site
866895004122	non-specific DNA binding site [nucleotide binding]; other site
866895004123	sequence-specific DNA binding site [nucleotide binding]; other site
866895004124	Protein of unknown function (DUF817); Region: DUF817; pfam05675
866895004125	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
866895004126	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
866895004127	putative NAD(P) binding site [chemical binding]; other site
866895004128	active site
866895004129	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
866895004130	Staygreen protein; Region: Staygreen; pfam12638
866895004131	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866895004132	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
866895004133	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
866895004134	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
866895004135	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
866895004137	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895004138	Coenzyme A binding pocket [chemical binding]; other site
866895004139	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
866895004140	putative dimer interface [polypeptide binding]; other site
866895004141	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895004142	ligand binding site [chemical binding]; other site
866895004143	Zn binding site [ion binding]; other site
866895004144	Transposase; Region: DEDD_Tnp_IS110; pfam01548
866895004145	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
866895004146	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
866895004147	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
866895004148	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895004149	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
866895004150	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895004151	NADH(P)-binding; Region: NAD_binding_10; pfam13460
866895004152	NAD(P) binding site [chemical binding]; other site
866895004153	active site
866895004154	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
866895004155	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
866895004156	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
866895004157	putative NAD(P) binding site [chemical binding]; other site
866895004158	dimer interface [polypeptide binding]; other site
866895004159	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
866895004160	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
866895004161	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
866895004162	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
866895004163	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866895004164	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866895004165	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866895004166	dimerization interface [polypeptide binding]; other site
866895004167	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
866895004168	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
866895004169	Domain of unknown function (DUF373); Region: DUF373; cl12079
866895004170	Sulphur transport; Region: Sulf_transp; pfam04143
866895004171	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
866895004172	Uncharacterized conserved protein [Function unknown]; Region: COG2968
866895004173	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
866895004174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895004175	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895004176	Probable transposase; Region: OrfB_IS605; pfam01385
866895004177	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895004178	zinc transporter ZupT; Provisional; Region: PRK04201
866895004179	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
866895004180	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
866895004181	tetrameric interface [polypeptide binding]; other site
866895004182	NAD binding site [chemical binding]; other site
866895004183	catalytic residues [active]
866895004184	mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568
866895004185	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
866895004186	putative active site [active]
866895004187	catalytic triad [active]
866895004188	multimer interface [polypeptide binding]; other site
866895004189	dimer interface [polypeptide binding]; other site
866895004190	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
866895004191	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866895004192	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895004193	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895004194	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
866895004195	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
866895004196	homodimer interface [polypeptide binding]; other site
866895004197	active site
866895004198	FMN binding site [chemical binding]; other site
866895004199	substrate binding site [chemical binding]; other site
866895004200	phenylhydantoinase; Validated; Region: PRK08323
866895004201	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
866895004202	tetramer interface [polypeptide binding]; other site
866895004203	active site
866895004204	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866895004205	Helix-turn-helix domain; Region: HTH_28; pfam13518
866895004206	putative transposase OrfB; Reviewed; Region: PHA02517
866895004207	HTH-like domain; Region: HTH_21; pfam13276
866895004208	Integrase core domain; Region: rve; pfam00665
866895004209	Integrase core domain; Region: rve_2; pfam13333
866895004210	nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483
866895004211	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
866895004212	Na binding site [ion binding]; other site
866895004213	substrate binding site [chemical binding]; other site
866895004214	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
866895004215	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
866895004216	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
866895004217	aminotransferase; Validated; Region: PRK07678
866895004218	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895004219	inhibitor-cofactor binding pocket; inhibition site
866895004220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895004221	catalytic residue [active]
866895004222	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
866895004223	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
866895004224	hexamer interface [polypeptide binding]; other site
866895004225	ligand binding site [chemical binding]; other site
866895004226	putative active site [active]
866895004227	NAD(P) binding site [chemical binding]; other site
866895004228	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895004229	dimerization interface [polypeptide binding]; other site
866895004230	putative DNA binding site [nucleotide binding]; other site
866895004231	putative Zn2+ binding site [ion binding]; other site
866895004232	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866895004233	metal-binding site [ion binding]
866895004234	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
866895004235	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866895004236	metal-binding site [ion binding]
866895004237	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866895004238	Soluble P-type ATPase [General function prediction only]; Region: COG4087
866895004239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
866895004240	Transposase; Region: DDE_Tnp_ISL3; pfam01610
866895004241	Protein of unknown function DUF45; Region: DUF45; cl00636
866895004242	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895004243	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895004244	Probable transposase; Region: OrfB_IS605; pfam01385
866895004245	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
866895004246	Small acid-soluble spore protein H family; Region: SspH; pfam08141
866895004247	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
866895004248	active site
866895004249	NAD binding site [chemical binding]; other site
866895004250	metal binding site [ion binding]; metal-binding site
866895004251	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866895004252	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
866895004253	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895004254	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895004255	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
866895004256	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
866895004257	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
866895004258	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
866895004259	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866895004260	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895004261	putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693
866895004262	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
866895004263	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
866895004264	YcaO-like family; Region: YcaO; pfam02624
866895004265	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
866895004266	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
866895004267	NADPH bind site [chemical binding]; other site
866895004268	putative FMN binding site [chemical binding]; other site
866895004269	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
866895004270	putative FMN binding site [chemical binding]; other site
866895004271	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
866895004272	hypothetical protein; Provisional; Region: PRK10621
866895004273	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
866895004274	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
866895004275	Active Sites [active]
866895004276	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
866895004277	ATP-sulfurylase; Region: ATPS; cd00517
866895004278	active site
866895004279	HXXH motif; other site
866895004280	flexible loop; other site
866895004281	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
866895004282	ligand-binding site [chemical binding]; other site
866895004283	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
866895004284	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
866895004285	active site
866895004286	SAM binding site [chemical binding]; other site
866895004287	homodimer interface [polypeptide binding]; other site
866895004288	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
866895004289	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
866895004290	putative active site [active]
866895004291	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
866895004292	putative active site [active]
866895004293	precorrin-2 dehydrogenase; Reviewed; Region: PRK06718
866895004294	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
866895004295	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
866895004296	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
866895004297	active site
866895004298	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
866895004299	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
866895004300	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
866895004301	FAD binding pocket [chemical binding]; other site
866895004302	FAD binding motif [chemical binding]; other site
866895004303	catalytic residues [active]
866895004304	NAD binding pocket [chemical binding]; other site
866895004305	phosphate binding motif [ion binding]; other site
866895004306	beta-alpha-beta structure motif; other site
866895004307	sulfite reductase subunit beta; Provisional; Region: PRK13504
866895004308	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
866895004309	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
866895004310	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
866895004311	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866895004312	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866895004313	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
866895004314	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866895004315	Predicted membrane protein [Function unknown]; Region: COG2323
866895004316	hypothetical protein; Provisional; Region: PRK11281
866895004317	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895004318	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895004319	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866895004320	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866895004321	Walker A/P-loop; other site
866895004322	ATP binding site [chemical binding]; other site
866895004323	Q-loop/lid; other site
866895004324	ABC transporter signature motif; other site
866895004325	Walker B; other site
866895004326	D-loop; other site
866895004327	H-loop/switch region; other site
866895004328	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
866895004329	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
866895004330	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
866895004331	Protein of unknown function (DUF664); Region: DUF664; pfam04978
866895004332	DinB superfamily; Region: DinB_2; pfam12867
866895004333	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895004334	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895004335	active site
866895004336	catalytic tetrad [active]
866895004337	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
866895004338	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895004339	Coenzyme A binding pocket [chemical binding]; other site
866895004340	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
866895004341	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866895004342	FeS/SAM binding site; other site
866895004343	YfkB-like domain; Region: YfkB; pfam08756
866895004344	short chain dehydrogenase; Provisional; Region: PRK06914
866895004345	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
866895004346	NADP binding site [chemical binding]; other site
866895004347	active site
866895004348	steroid binding site; other site
866895004349	Esterase/lipase [General function prediction only]; Region: COG1647
866895004350	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
866895004351	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
866895004352	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
866895004353	putative active site [active]
866895004354	putative catalytic site [active]
866895004355	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
866895004356	PLD-like domain; Region: PLDc_2; pfam13091
866895004357	putative active site [active]
866895004358	putative catalytic site [active]
866895004359	Heat induced stress protein YflT; Region: YflT; pfam11181
866895004360	Uncharacterized conserved protein [Function unknown]; Region: COG3342
866895004361	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
866895004362	Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823
866895004363	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866895004364	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
866895004365	Helix-turn-helix domain; Region: HTH_28; pfam13518
866895004366	putative transposase OrfB; Reviewed; Region: PHA02517
866895004367	HTH-like domain; Region: HTH_21; pfam13276
866895004368	Integrase core domain; Region: rve; pfam00665
866895004369	Integrase core domain; Region: rve_2; pfam13333
866895004370	Domain of unknown function (DUF4181); Region: DUF4181; pfam13789
866895004371	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895004372	putative DNA binding site [nucleotide binding]; other site
866895004373	dimerization interface [polypeptide binding]; other site
866895004374	putative Zn2+ binding site [ion binding]; other site
866895004375	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589
866895004376	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895004377	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895004378	Probable transposase; Region: OrfB_IS605; pfam01385
866895004379	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895004380	H+ Antiporter protein; Region: 2A0121; TIGR00900
866895004381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895004382	putative substrate translocation pore; other site
866895004383	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
866895004384	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
866895004385	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
866895004386	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
866895004387	4Fe-4S binding domain; Region: Fer4_6; pfam12837
866895004388	4Fe-4S binding domain; Region: Fer4; pfam00037
866895004389	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
866895004390	[4Fe-4S] binding site [ion binding]; other site
866895004391	molybdopterin cofactor binding site; other site
866895004392	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
866895004393	molybdopterin cofactor binding site; other site
866895004394	Uncharacterized conserved protein [Function unknown]; Region: COG2427
866895004395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
866895004396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
866895004397	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895004398	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895004399	active site
866895004400	catalytic tetrad [active]
866895004401	Penicillin amidase; Region: Penicil_amidase; pfam01804
866895004402	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
866895004403	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
866895004404	active site
866895004405	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
866895004406	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
866895004407	potential catalytic triad [active]
866895004408	conserved cys residue [active]
866895004409	Uncharacterized conserved protein [Function unknown]; Region: COG1359
866895004410	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
866895004411	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
866895004412	tetrameric interface [polypeptide binding]; other site
866895004413	activator binding site; other site
866895004414	NADP binding site [chemical binding]; other site
866895004415	substrate binding site [chemical binding]; other site
866895004416	catalytic residues [active]
866895004417	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
866895004418	NAD-dependent deacetylase; Provisional; Region: PRK00481
866895004419	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
866895004420	NAD+ binding site [chemical binding]; other site
866895004421	substrate binding site [chemical binding]; other site
866895004422	Zn binding site [ion binding]; other site
866895004423	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
866895004424	dimer interface [polypeptide binding]; other site
866895004425	FMN binding site [chemical binding]; other site
866895004426	NADPH bind site [chemical binding]; other site
866895004427	Microsomal signal peptidase 12 kDa subunit (SPC12); Region: SPC12; pfam06645
866895004428	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895004429	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
866895004430	Walker A/P-loop; other site
866895004431	ATP binding site [chemical binding]; other site
866895004432	Q-loop/lid; other site
866895004433	ABC transporter signature motif; other site
866895004434	Walker B; other site
866895004435	D-loop; other site
866895004436	H-loop/switch region; other site
866895004437	ABC-2 type transporter; Region: ABC2_membrane; cl17235
866895004438	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
866895004439	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866895004440	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895004441	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866895004442	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866895004443	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895004444	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866895004445	VanW like protein; Region: VanW; pfam04294
866895004446	Predicted GTPases [General function prediction only]; Region: COG1162
866895004447	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
866895004448	RNA binding site [nucleotide binding]; other site
866895004449	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
866895004450	GTPase/Zn-binding domain interface [polypeptide binding]; other site
866895004451	GTP/Mg2+ binding site [chemical binding]; other site
866895004452	G4 box; other site
866895004453	G5 box; other site
866895004454	G1 box; other site
866895004455	Switch I region; other site
866895004456	G2 box; other site
866895004457	G3 box; other site
866895004458	Switch II region; other site
866895004459	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
866895004460	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
866895004461	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
866895004462	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
866895004463	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
866895004464	DHHA2 domain; Region: DHHA2; pfam02833
866895004465	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866895004466	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895004467	Coenzyme A binding pocket [chemical binding]; other site
866895004468	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
866895004469	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
866895004470	oligomer interface [polypeptide binding]; other site
866895004471	metal binding site [ion binding]; metal-binding site
866895004472	metal binding site [ion binding]; metal-binding site
866895004473	putative Cl binding site [ion binding]; other site
866895004474	aspartate ring; other site
866895004475	basic sphincter; other site
866895004476	hydrophobic gate; other site
866895004477	periplasmic entrance; other site
866895004478	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
866895004479	putative mercuric reductase; Provisional; Region: PRK14694
866895004480	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
866895004481	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895004482	NAD(P) binding site [chemical binding]; other site
866895004483	active site
866895004484	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866895004485	Zn2+ binding site [ion binding]; other site
866895004486	Mg2+ binding site [ion binding]; other site
866895004487	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
866895004488	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
866895004489	dimer interface [polypeptide binding]; other site
866895004490	putative functional site; other site
866895004491	putative MPT binding site; other site
866895004492	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
866895004493	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866895004494	FeS/SAM binding site; other site
866895004495	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
866895004496	Transposase; Region: DEDD_Tnp_IS110; pfam01548
866895004497	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
866895004498	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
866895004499	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
866895004500	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
866895004501	putative NAD(P) binding site [chemical binding]; other site
866895004502	YwpF-like protein; Region: YwpF; pfam14183
866895004503	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
866895004504	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
866895004505	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853
866895004506	phytoene desaturase; Region: crtI_fam; TIGR02734
866895004507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895004508	phytoene desaturase; Region: crtI_fam; TIGR02734
866895004509	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895004510	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
866895004511	active site lid residues [active]
866895004512	substrate binding pocket [chemical binding]; other site
866895004513	catalytic residues [active]
866895004514	substrate-Mg2+ binding site; other site
866895004515	aspartate-rich region 1; other site
866895004516	aspartate-rich region 2; other site
866895004517	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895004518	phytoene desaturase; Region: crtI_fam; TIGR02734
866895004519	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866895004520	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866895004521	active site
866895004522	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
866895004523	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
866895004524	putative acyl-acceptor binding pocket; other site
866895004525	Protein of unknown function (DUF422); Region: DUF422; cl00991
866895004526	Predicted membrane protein [Function unknown]; Region: COG2259
866895004527	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
866895004528	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
866895004529	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
866895004530	YvrJ protein family; Region: YvrJ; pfam12841
866895004531	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
866895004532	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
866895004533	Catalytic site [active]
866895004534	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
866895004535	aminotransferase A; Validated; Region: PRK07683
866895004536	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866895004537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895004538	homodimer interface [polypeptide binding]; other site
866895004539	catalytic residue [active]
866895004540	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
866895004541	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
866895004542	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
866895004543	active site
866895004544	nucleophile elbow; other site
866895004545	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
866895004546	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
866895004547	active site
866895004548	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
866895004549	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
866895004550	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895004551	active site
866895004552	phosphorylation site [posttranslational modification]
866895004553	intermolecular recognition site; other site
866895004554	dimerization interface [polypeptide binding]; other site
866895004555	tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334
866895004556	YkyB-like protein; Region: YkyB; pfam14177
866895004557	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
866895004558	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
866895004559	Cu(I) binding site [ion binding]; other site
866895004560	phosphodiesterase YaeI; Provisional; Region: PRK11340
866895004561	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
866895004562	putative active site [active]
866895004563	putative metal binding site [ion binding]; other site
866895004564	short chain dehydrogenase; Provisional; Region: PRK07677
866895004565	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
866895004566	NAD(P) binding site [chemical binding]; other site
866895004567	substrate binding site [chemical binding]; other site
866895004568	homotetramer interface [polypeptide binding]; other site
866895004569	active site
866895004570	homodimer interface [polypeptide binding]; other site
866895004571	Haemolysin-III related; Region: HlyIII; cl03831
866895004572	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
866895004573	FOG: CBS domain [General function prediction only]; Region: COG0517
866895004574	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
866895004575	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895004576	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895004577	putative substrate translocation pore; other site
866895004578	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
866895004579	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
866895004580	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
866895004581	trimer interface [polypeptide binding]; other site
866895004582	active site
866895004583	substrate binding site [chemical binding]; other site
866895004584	CoA binding site [chemical binding]; other site
866895004585	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866895004586	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
866895004587	metal binding site [ion binding]; metal-binding site
866895004588	Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698
866895004589	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
866895004590	Domain of unknown function DUF21; Region: DUF21; pfam01595
866895004591	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866895004592	Transporter associated domain; Region: CorC_HlyC; smart01091
866895004593	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866895004594	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866895004595	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
866895004596	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
866895004597	dimer interface [polypeptide binding]; other site
866895004598	decamer (pentamer of dimers) interface [polypeptide binding]; other site
866895004599	catalytic triad [active]
866895004600	peroxidatic and resolving cysteines [active]
866895004601	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
866895004602	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866895004603	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866895004604	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895004605	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
866895004606	Walker A/P-loop; other site
866895004607	ATP binding site [chemical binding]; other site
866895004608	Q-loop/lid; other site
866895004609	ABC transporter signature motif; other site
866895004610	Walker B; other site
866895004611	D-loop; other site
866895004612	H-loop/switch region; other site
866895004613	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866895004614	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895004615	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
866895004616	Walker A/P-loop; other site
866895004617	ATP binding site [chemical binding]; other site
866895004618	Q-loop/lid; other site
866895004619	ABC transporter signature motif; other site
866895004620	Walker B; other site
866895004621	D-loop; other site
866895004622	H-loop/switch region; other site
866895004623	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
866895004624	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
866895004625	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
866895004626	TrkA-N domain; Region: TrkA_N; pfam02254
866895004627	TrkA-C domain; Region: TrkA_C; pfam02080
866895004628	pyruvate oxidase; Provisional; Region: PRK08611
866895004629	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
866895004630	PYR/PP interface [polypeptide binding]; other site
866895004631	tetramer interface [polypeptide binding]; other site
866895004632	dimer interface [polypeptide binding]; other site
866895004633	TPP binding site [chemical binding]; other site
866895004634	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866895004635	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
866895004636	TPP-binding site [chemical binding]; other site
866895004637	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
866895004638	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866895004639	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
866895004640	Protein of unknown function (DUF1447); Region: DUF1447; cl11492
866895004641	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895004642	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866895004643	active site
866895004644	motif I; other site
866895004645	motif II; other site
866895004646	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866895004647	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
866895004648	active site
866895004649	catalytic residues [active]
866895004650	metal binding site [ion binding]; metal-binding site
866895004651	Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368
866895004652	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
866895004653	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
866895004654	TPP-binding site [chemical binding]; other site
866895004655	tetramer interface [polypeptide binding]; other site
866895004656	heterodimer interface [polypeptide binding]; other site
866895004657	phosphorylation loop region [posttranslational modification]
866895004658	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
866895004659	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
866895004660	alpha subunit interface [polypeptide binding]; other site
866895004661	TPP binding site [chemical binding]; other site
866895004662	heterodimer interface [polypeptide binding]; other site
866895004663	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866895004664	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866895004665	E3 interaction surface; other site
866895004666	lipoyl attachment site [posttranslational modification]; other site
866895004667	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
866895004668	e3 binding domain; Region: E3_binding; pfam02817
866895004669	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
866895004670	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
866895004671	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895004672	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895004673	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866895004674	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866895004675	BCCT family transporter; Region: BCCT; pfam02028
866895004676	Predicted membrane protein [Function unknown]; Region: COG4129
866895004677	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
866895004678	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
866895004679	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
866895004680	NodB motif; other site
866895004681	active site
866895004682	catalytic site [active]
866895004683	metal binding site [ion binding]; metal-binding site
866895004684	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
866895004685	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
866895004686	homodimer interface [polypeptide binding]; other site
866895004687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895004688	catalytic residue [active]
866895004689	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
866895004690	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
866895004691	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
866895004692	FMN binding site [chemical binding]; other site
866895004693	substrate binding site [chemical binding]; other site
866895004694	putative catalytic residue [active]
866895004695	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
866895004696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
866895004697	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
866895004698	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
866895004699	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
866895004700	active site
866895004701	YlaH-like protein; Region: YlaH; pfam14036
866895004702	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
866895004703	glutaminase A; Region: Gln_ase; TIGR03814
866895004704	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
866895004705	hypothetical protein; Provisional; Region: PRK13666
866895004706	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
866895004707	pyruvate carboxylase; Reviewed; Region: PRK12999
866895004708	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866895004709	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866895004710	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
866895004711	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
866895004712	active site
866895004713	catalytic residues [active]
866895004714	metal binding site [ion binding]; metal-binding site
866895004715	homodimer binding site [polypeptide binding]; other site
866895004716	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866895004717	carboxyltransferase (CT) interaction site; other site
866895004718	biotinylation site [posttranslational modification]; other site
866895004719	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
866895004720	UbiA prenyltransferase family; Region: UbiA; pfam01040
866895004721	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
866895004722	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
866895004723	cytochrome c-550; Provisional; Region: psbV; cl17239
866895004724	Cytochrome c; Region: Cytochrom_C; pfam00034
866895004725	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
866895004726	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
866895004727	D-pathway; other site
866895004728	Putative ubiquinol binding site [chemical binding]; other site
866895004729	Low-spin heme (heme b) binding site [chemical binding]; other site
866895004730	Putative water exit pathway; other site
866895004731	Binuclear center (heme o3/CuB) [ion binding]; other site
866895004732	K-pathway; other site
866895004733	Putative proton exit pathway; other site
866895004734	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
866895004735	Subunit I/III interface [polypeptide binding]; other site
866895004736	Subunit III/IV interface [polypeptide binding]; other site
866895004737	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
866895004738	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
866895004739	Protein of unknown function (DUF420); Region: DUF420; pfam04238
866895004740	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866895004741	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895004742	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
866895004743	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866895004744	YugN-like family; Region: YugN; pfam08868
866895004745	FOG: CBS domain [General function prediction only]; Region: COG0517
866895004746	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
866895004747	Putative coat protein; Region: YlbD_coat; pfam14071
866895004748	Protein of unknown function (DUF964); Region: DUF964; pfam06133
866895004749	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
866895004750	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
866895004751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895004752	S-adenosylmethionine binding site [chemical binding]; other site
866895004753	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
866895004754	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
866895004755	active site
866895004756	(T/H)XGH motif; other site
866895004757	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
866895004758	Nucleoside recognition; Region: Gate; pfam07670
866895004759	hypothetical protein; Provisional; Region: PRK10279
866895004760	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
866895004761	active site
866895004762	nucleophile elbow; other site
866895004763	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
866895004764	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
866895004765	protein binding site [polypeptide binding]; other site
866895004766	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
866895004767	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
866895004768	hypothetical protein; Provisional; Region: PRK13670
866895004769	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
866895004770	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
866895004771	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
866895004772	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866895004773	substrate binding site [chemical binding]; other site
866895004774	oxyanion hole (OAH) forming residues; other site
866895004775	trimer interface [polypeptide binding]; other site
866895004776	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
866895004777	hypothetical protein; Provisional; Region: PRK13688
866895004778	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866895004779	Coenzyme A binding pocket [chemical binding]; other site
866895004780	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
866895004781	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
866895004782	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
866895004783	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
866895004784	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
866895004785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
866895004786	cell division protein MraZ; Reviewed; Region: PRK00326
866895004787	MraZ protein; Region: MraZ; pfam02381
866895004788	MraZ protein; Region: MraZ; pfam02381
866895004789	MraW methylase family; Region: Methyltransf_5; pfam01795
866895004790	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
866895004791	Cell division protein FtsL; Region: FtsL; cl11433
866895004792	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
866895004793	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866895004794	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866895004795	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
866895004796	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
866895004797	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
866895004798	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866895004799	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866895004800	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
866895004801	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
866895004802	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866895004803	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895004804	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866895004805	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
866895004806	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866895004807	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895004808	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866895004809	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
866895004810	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
866895004811	Mg++ binding site [ion binding]; other site
866895004812	putative catalytic motif [active]
866895004813	putative substrate binding site [chemical binding]; other site
866895004814	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
866895004815	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895004816	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866895004817	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
866895004818	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
866895004819	Cell division protein FtsQ; Region: FtsQ; pfam03799
866895004820	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
866895004821	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866895004822	nucleotide binding site [chemical binding]; other site
866895004823	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
866895004824	Cell division protein FtsA; Region: FtsA; pfam14450
866895004825	cell division protein FtsZ; Validated; Region: PRK09330
866895004826	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
866895004827	nucleotide binding site [chemical binding]; other site
866895004828	SulA interaction site; other site
866895004829	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
866895004830	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
866895004831	sporulation sigma factor SigE; Reviewed; Region: PRK08301
866895004832	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895004833	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895004834	DNA binding residues [nucleotide binding]
866895004835	sporulation sigma factor SigG; Reviewed; Region: PRK08215
866895004836	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895004837	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
866895004838	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895004839	DNA binding residues [nucleotide binding]
866895004840	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
866895004841	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
866895004842	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
866895004843	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
866895004844	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866895004845	catalytic residue [active]
866895004846	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
866895004847	YGGT family; Region: YGGT; pfam02325
866895004848	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
866895004849	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866895004850	RNA binding surface [nucleotide binding]; other site
866895004851	DivIVA protein; Region: DivIVA; pfam05103
866895004852	DivIVA domain; Region: DivI1A_domain; TIGR03544
866895004853	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
866895004854	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
866895004855	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866895004856	RNA binding surface [nucleotide binding]; other site
866895004857	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866895004858	active site
866895004859	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
866895004860	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895004861	active site
866895004862	uracil transporter; Provisional; Region: PRK10720
866895004863	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
866895004864	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
866895004865	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
866895004866	dihydroorotase; Validated; Region: pyrC; PRK09357
866895004867	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
866895004868	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
866895004869	active site
866895004870	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
866895004871	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
866895004872	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
866895004873	catalytic site [active]
866895004874	subunit interface [polypeptide binding]; other site
866895004875	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
866895004876	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866895004877	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
866895004878	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
866895004879	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866895004880	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866895004881	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
866895004882	IMP binding site; other site
866895004883	dimer interface [polypeptide binding]; other site
866895004884	interdomain contacts; other site
866895004885	partial ornithine binding site; other site
866895004886	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
866895004887	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
866895004888	FAD binding pocket [chemical binding]; other site
866895004889	FAD binding motif [chemical binding]; other site
866895004890	phosphate binding motif [ion binding]; other site
866895004891	beta-alpha-beta structure motif; other site
866895004892	NAD binding pocket [chemical binding]; other site
866895004893	Iron coordination center [ion binding]; other site
866895004894	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
866895004895	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
866895004896	heterodimer interface [polypeptide binding]; other site
866895004897	active site
866895004898	FMN binding site [chemical binding]; other site
866895004899	homodimer interface [polypeptide binding]; other site
866895004900	substrate binding site [chemical binding]; other site
866895004901	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
866895004902	active site
866895004903	dimer interface [polypeptide binding]; other site
866895004904	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895004905	active site
866895004906	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
866895004907	Domain of unknown function (DUF814); Region: DUF814; pfam05670
866895004908	hypothetical protein; Provisional; Region: PRK11820
866895004909	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
866895004910	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
866895004911	hypothetical protein; Provisional; Region: PRK04323
866895004912	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
866895004913	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
866895004914	catalytic site [active]
866895004915	G-X2-G-X-G-K; other site
866895004916	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
866895004917	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
866895004918	Flavoprotein; Region: Flavoprotein; pfam02441
866895004919	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
866895004920	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
866895004921	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895004922	ATP binding site [chemical binding]; other site
866895004923	putative Mg++ binding site [ion binding]; other site
866895004924	nucleotide binding region [chemical binding]; other site
866895004925	helicase superfamily c-terminal domain; Region: HELICc; smart00490
866895004926	ATP-binding site [chemical binding]; other site
866895004927	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
866895004928	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
866895004929	putative active site [active]
866895004930	substrate binding site [chemical binding]; other site
866895004931	putative cosubstrate binding site; other site
866895004932	catalytic site [active]
866895004933	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
866895004934	substrate binding site [chemical binding]; other site
866895004935	16S rRNA methyltransferase B; Provisional; Region: PRK14902
866895004936	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
866895004937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895004938	S-adenosylmethionine binding site [chemical binding]; other site
866895004939	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
866895004940	Protein phosphatase 2C; Region: PP2C; pfam00481
866895004941	active site
866895004942	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
866895004943	Catalytic domain of Protein Kinases; Region: PKc; cd00180
866895004944	active site
866895004945	ATP binding site [chemical binding]; other site
866895004946	substrate binding site [chemical binding]; other site
866895004947	activation loop (A-loop); other site
866895004948	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
866895004949	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866895004950	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866895004951	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866895004952	GTPase RsgA; Reviewed; Region: PRK00098
866895004953	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
866895004954	RNA binding site [nucleotide binding]; other site
866895004955	homodimer interface [polypeptide binding]; other site
866895004956	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
866895004957	GTPase/Zn-binding domain interface [polypeptide binding]; other site
866895004958	GTP/Mg2+ binding site [chemical binding]; other site
866895004959	G4 box; other site
866895004960	G5 box; other site
866895004961	G1 box; other site
866895004962	Switch I region; other site
866895004963	G2 box; other site
866895004964	G3 box; other site
866895004965	Switch II region; other site
866895004966	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
866895004967	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
866895004968	substrate binding site [chemical binding]; other site
866895004969	hexamer interface [polypeptide binding]; other site
866895004970	metal binding site [ion binding]; metal-binding site
866895004971	Thiamine pyrophosphokinase; Region: TPK; cd07995
866895004972	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
866895004973	active site
866895004974	dimerization interface [polypeptide binding]; other site
866895004975	thiamine binding site [chemical binding]; other site
866895004976	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
866895004977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
866895004978	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
866895004979	DAK2 domain; Region: Dak2; pfam02734
866895004980	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895004981	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
866895004982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895004983	putative substrate translocation pore; other site
866895004984	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
866895004985	classical (c) SDRs; Region: SDR_c; cd05233
866895004986	NAD(P) binding site [chemical binding]; other site
866895004987	active site
866895004988	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
866895004989	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
866895004990	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
866895004991	putative dimer interface [polypeptide binding]; other site
866895004992	Predicted membrane protein [Function unknown]; Region: COG2322
866895004993	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
866895004994	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
866895004995	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866895004996	FeS/SAM binding site; other site
866895004997	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866895004998	Ligand Binding Site [chemical binding]; other site
866895004999	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895005000	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895005001	DNA binding site [nucleotide binding]
866895005002	domain linker motif; other site
866895005003	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
866895005004	putative dimerization interface [polypeptide binding]; other site
866895005005	putative ligand binding site [chemical binding]; other site
866895005006	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866895005007	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866895005008	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
866895005009	putative homodimer interface [polypeptide binding]; other site
866895005010	putative homotetramer interface [polypeptide binding]; other site
866895005011	putative allosteric switch controlling residues; other site
866895005012	putative metal binding site [ion binding]; other site
866895005013	putative homodimer-homodimer interface [polypeptide binding]; other site
866895005014	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
866895005015	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866895005016	metal-binding site [ion binding]
866895005017	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
866895005018	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866895005019	metal-binding site [ion binding]
866895005020	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866895005021	Soluble P-type ATPase [General function prediction only]; Region: COG4087
866895005022	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
866895005023	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866895005024	Soluble P-type ATPase [General function prediction only]; Region: COG4087
866895005025	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
866895005026	nudix motif; other site
866895005027	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
866895005028	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
866895005029	active site
866895005030	metal binding site [ion binding]; metal-binding site
866895005031	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
866895005032	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
866895005033	active site
866895005034	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866895005035	EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388
866895005036	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
866895005037	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
866895005038	putative active site [active]
866895005039	putative FMN binding site [chemical binding]; other site
866895005040	putative substrate binding site [chemical binding]; other site
866895005041	putative catalytic residue [active]
866895005042	4Fe-4S binding domain; Region: Fer4; pfam00037
866895005043	Pirin; Region: Pirin; pfam02678
866895005044	Pirin-related protein [General function prediction only]; Region: COG1741
866895005045	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
866895005046	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866895005047	MarR family; Region: MarR_2; cl17246
866895005048	Protein of unknown function (DUF997); Region: DUF997; pfam06196
866895005049	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
866895005050	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
866895005051	Na binding site [ion binding]; other site
866895005052	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
866895005053	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
866895005054	siderophore binding site; other site
866895005055	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866895005056	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866895005057	ABC-ATPase subunit  interface; other site
866895005058	dimer interface [polypeptide binding]; other site
866895005059	putative PBP binding regions; other site
866895005060	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866895005061	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866895005062	ABC-ATPase subunit  interface; other site
866895005063	dimer interface [polypeptide binding]; other site
866895005064	putative PBP binding regions; other site
866895005065	Endonuclease I; Region: Endonuclease_1; cl01003
866895005066	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895005067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
866895005068	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
866895005069	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
866895005070	Putative ammonia monooxygenase; Region: AmoA; pfam05145
866895005071	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
866895005072	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
866895005073	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
866895005074	carbohydrate binding site [chemical binding]; other site
866895005075	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
866895005076	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
866895005077	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
866895005078	Ca binding site [ion binding]; other site
866895005079	active site
866895005080	catalytic site [active]
866895005081	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895005082	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895005083	DNA binding site [nucleotide binding]
866895005084	domain linker motif; other site
866895005085	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866895005086	ligand binding site [chemical binding]; other site
866895005087	dimerization interface [polypeptide binding]; other site
866895005088	Small acid-soluble spore protein H family; Region: SspH; pfam08141
866895005089	LysE type translocator; Region: LysE; pfam01810
866895005090	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
866895005091	active site
866895005092	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
866895005093	Transposase; Region: DDE_Tnp_ISL3; pfam01610
866895005094	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
866895005095	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866895005096	FeS/SAM binding site; other site
866895005097	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
866895005098	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
866895005099	NAD binding site [chemical binding]; other site
866895005100	substrate binding site [chemical binding]; other site
866895005101	catalytic Zn binding site [ion binding]; other site
866895005102	tetramer interface [polypeptide binding]; other site
866895005103	structural Zn binding site [ion binding]; other site
866895005104	Pyruvate formate lyase 1; Region: PFL1; cd01678
866895005105	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
866895005106	coenzyme A binding site [chemical binding]; other site
866895005107	active site
866895005108	catalytic residues [active]
866895005109	glycine loop; other site
866895005110	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
866895005111	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
866895005112	classical (c) SDRs; Region: SDR_c; cd05233
866895005113	NAD(P) binding site [chemical binding]; other site
866895005114	active site
866895005115	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895005116	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895005117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895005118	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895005119	putative substrate translocation pore; other site
866895005120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895005121	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
866895005122	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
866895005123	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
866895005124	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
866895005125	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
866895005126	acyl-activating enzyme (AAE) consensus motif; other site
866895005127	AMP binding site [chemical binding]; other site
866895005128	active site
866895005129	CoA binding site [chemical binding]; other site
866895005130	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
866895005131	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866895005132	NAD binding site [chemical binding]; other site
866895005133	catalytic residues [active]
866895005134	SET domain; Region: SET; pfam00856
866895005135	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
866895005136	active site
866895005137	DNA binding site [nucleotide binding]
866895005138	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
866895005139	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895005140	NAD(P) binding site [chemical binding]; other site
866895005141	active site
866895005142	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
866895005143	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
866895005144	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866895005145	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895005146	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866895005147	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
866895005148	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
866895005149	active site
866895005150	metal binding site [ion binding]; metal-binding site
866895005151	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
866895005152	S-layer homology domain; Region: SLH; pfam00395
866895005153	S-layer homology domain; Region: SLH; pfam00395
866895005154	S-layer homology domain; Region: SLH; pfam00395
866895005155	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
866895005156	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
866895005157	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
866895005158	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
866895005159	putative L-serine binding site [chemical binding]; other site
866895005160	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
866895005161	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
866895005162	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
866895005163	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
866895005164	generic binding surface II; other site
866895005165	ssDNA binding site; other site
866895005166	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895005167	ATP binding site [chemical binding]; other site
866895005168	putative Mg++ binding site [ion binding]; other site
866895005169	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895005170	nucleotide binding region [chemical binding]; other site
866895005171	ATP-binding site [chemical binding]; other site
866895005172	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
866895005173	dimer interface [polypeptide binding]; other site
866895005174	catalytic triad [active]
866895005175	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
866895005176	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
866895005177	active site 2 [active]
866895005178	active site 1 [active]
866895005179	putative phosphate acyltransferase; Provisional; Region: PRK05331
866895005180	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
866895005181	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
866895005182	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
866895005183	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
866895005184	NAD(P) binding site [chemical binding]; other site
866895005185	homotetramer interface [polypeptide binding]; other site
866895005186	homodimer interface [polypeptide binding]; other site
866895005187	active site
866895005188	acyl carrier protein; Provisional; Region: acpP; PRK00982
866895005189	ribonuclease III; Reviewed; Region: rnc; PRK00102
866895005190	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
866895005191	dimerization interface [polypeptide binding]; other site
866895005192	active site
866895005193	metal binding site [ion binding]; metal-binding site
866895005194	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
866895005195	dsRNA binding site [nucleotide binding]; other site
866895005196	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
866895005197	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
866895005198	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
866895005199	Walker A/P-loop; other site
866895005200	ATP binding site [chemical binding]; other site
866895005201	Q-loop/lid; other site
866895005202	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
866895005203	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
866895005204	ABC transporter signature motif; other site
866895005205	Walker B; other site
866895005206	D-loop; other site
866895005207	H-loop/switch region; other site
866895005208	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
866895005209	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
866895005210	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
866895005211	P loop; other site
866895005212	GTP binding site [chemical binding]; other site
866895005213	putative DNA-binding protein; Validated; Region: PRK00118
866895005214	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
866895005215	signal recognition particle protein; Provisional; Region: PRK10867
866895005216	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
866895005217	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
866895005218	P loop; other site
866895005219	GTP binding site [chemical binding]; other site
866895005220	Signal peptide binding domain; Region: SRP_SPB; pfam02978
866895005221	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
866895005222	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
866895005223	KH domain; Region: KH_4; pfam13083
866895005224	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
866895005225	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
866895005226	RimM N-terminal domain; Region: RimM; pfam01782
866895005227	PRC-barrel domain; Region: PRC; pfam05239
866895005228	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
866895005229	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
866895005230	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
866895005231	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
866895005232	Catalytic site [active]
866895005233	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
866895005234	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
866895005235	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
866895005236	GTP/Mg2+ binding site [chemical binding]; other site
866895005237	G4 box; other site
866895005238	G5 box; other site
866895005239	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
866895005240	G1 box; other site
866895005241	G1 box; other site
866895005242	GTP/Mg2+ binding site [chemical binding]; other site
866895005243	Switch I region; other site
866895005244	G2 box; other site
866895005245	G2 box; other site
866895005246	Switch I region; other site
866895005247	G3 box; other site
866895005248	G3 box; other site
866895005249	Switch II region; other site
866895005250	Switch II region; other site
866895005251	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
866895005252	RNA/DNA hybrid binding site [nucleotide binding]; other site
866895005253	active site
866895005254	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
866895005255	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
866895005256	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
866895005257	CoA-ligase; Region: Ligase_CoA; pfam00549
866895005258	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
866895005259	CoA binding domain; Region: CoA_binding; pfam02629
866895005260	CoA-ligase; Region: Ligase_CoA; pfam00549
866895005261	DNA protecting protein DprA; Region: dprA; TIGR00732
866895005262	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
866895005263	DNA topoisomerase I; Validated; Region: PRK05582
866895005264	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
866895005265	active site
866895005266	interdomain interaction site; other site
866895005267	putative metal-binding site [ion binding]; other site
866895005268	nucleotide binding site [chemical binding]; other site
866895005269	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
866895005270	domain I; other site
866895005271	DNA binding groove [nucleotide binding]
866895005272	phosphate binding site [ion binding]; other site
866895005273	domain II; other site
866895005274	domain III; other site
866895005275	nucleotide binding site [chemical binding]; other site
866895005276	catalytic site [active]
866895005277	domain IV; other site
866895005278	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866895005279	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866895005280	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866895005281	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
866895005282	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
866895005283	active site
866895005284	Int/Topo IB signature motif; other site
866895005285	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
866895005286	active site
866895005287	HslU subunit interaction site [polypeptide binding]; other site
866895005288	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
866895005289	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
866895005290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895005291	Walker A motif; other site
866895005292	ATP binding site [chemical binding]; other site
866895005293	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
866895005294	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
866895005295	transcriptional repressor CodY; Validated; Region: PRK04158
866895005296	CodY GAF-like domain; Region: CodY; pfam06018
866895005297	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
866895005298	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
866895005299	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
866895005300	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
866895005301	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
866895005302	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
866895005303	flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728
866895005304	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
866895005305	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
866895005306	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
866895005307	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
866895005308	FliG C-terminal domain; Region: FliG_C; pfam01706
866895005309	flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825
866895005310	Flagellar assembly protein FliH; Region: FliH; pfam02108
866895005311	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721
866895005312	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866895005313	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
866895005314	Walker A motif/ATP binding site; other site
866895005315	Walker B motif; other site
866895005316	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
866895005317	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
866895005318	Uncharacterized conserved protein [Function unknown]; Region: COG3334
866895005319	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
866895005320	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
866895005321	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
866895005322	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
866895005323	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
866895005324	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
866895005325	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
866895005326	Flagellar protein (FlbD); Region: FlbD; pfam06289
866895005327	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
866895005328	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
866895005329	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
866895005330	flagellar motor switch protein; Validated; Region: PRK08119
866895005331	CheC-like family; Region: CheC; pfam04509
866895005332	CheC-like family; Region: CheC; pfam04509
866895005333	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
866895005334	Response regulator receiver domain; Region: Response_reg; pfam00072
866895005335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895005336	active site
866895005337	phosphorylation site [posttranslational modification]
866895005338	intermolecular recognition site; other site
866895005339	dimerization interface [polypeptide binding]; other site
866895005340	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
866895005341	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
866895005342	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
866895005343	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
866895005344	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
866895005345	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
866895005346	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
866895005347	FHIPEP family; Region: FHIPEP; pfam00771
866895005348	Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419
866895005349	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866895005350	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
866895005351	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866895005352	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
866895005353	CheB methylesterase; Region: CheB_methylest; pfam01339
866895005354	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
866895005355	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
866895005356	putative binding surface; other site
866895005357	active site
866895005358	P2 response regulator binding domain; Region: P2; pfam07194
866895005359	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
866895005360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895005361	ATP binding site [chemical binding]; other site
866895005362	Mg2+ binding site [ion binding]; other site
866895005363	G-X-G motif; other site
866895005364	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
866895005365	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
866895005366	putative CheA interaction surface; other site
866895005367	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
866895005368	CheC-like family; Region: CheC; pfam04509
866895005369	CheC-like family; Region: CheC; pfam04509
866895005370	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
866895005371	RNA polymerase sigma factor SigD; Validated; Region: PRK07670
866895005372	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895005373	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
866895005374	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895005375	DNA binding residues [nucleotide binding]
866895005376	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
866895005377	rRNA interaction site [nucleotide binding]; other site
866895005378	S8 interaction site; other site
866895005379	putative laminin-1 binding site; other site
866895005380	elongation factor Ts; Provisional; Region: tsf; PRK09377
866895005381	UBA/TS-N domain; Region: UBA; pfam00627
866895005382	Elongation factor TS; Region: EF_TS; pfam00889
866895005383	Elongation factor TS; Region: EF_TS; pfam00889
866895005384	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
866895005385	putative nucleotide binding site [chemical binding]; other site
866895005386	uridine monophosphate binding site [chemical binding]; other site
866895005387	homohexameric interface [polypeptide binding]; other site
866895005388	ribosome recycling factor; Reviewed; Region: frr; PRK00083
866895005389	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
866895005390	hinge region; other site
866895005391	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
866895005392	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
866895005393	catalytic residue [active]
866895005394	putative FPP diphosphate  binding site; other site
866895005395	putative FPP binding hydrophobic cleft; other site
866895005396	dimer interface [polypeptide binding]; other site
866895005397	putative IPP diphosphate binding site; other site
866895005398	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
866895005399	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
866895005400	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
866895005401	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
866895005402	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
866895005403	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
866895005404	RIP metalloprotease RseP; Region: TIGR00054
866895005405	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
866895005406	active site
866895005407	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
866895005408	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
866895005409	protein binding site [polypeptide binding]; other site
866895005410	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
866895005411	putative substrate binding region [chemical binding]; other site
866895005412	prolyl-tRNA synthetase; Provisional; Region: PRK09194
866895005413	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
866895005414	dimer interface [polypeptide binding]; other site
866895005415	motif 1; other site
866895005416	active site
866895005417	motif 2; other site
866895005418	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
866895005419	putative deacylase active site [active]
866895005420	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866895005421	active site
866895005422	motif 3; other site
866895005423	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
866895005424	anticodon binding site; other site
866895005425	DNA polymerase III PolC; Validated; Region: polC; PRK00448
866895005426	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
866895005427	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
866895005428	generic binding surface II; other site
866895005429	generic binding surface I; other site
866895005430	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
866895005431	active site
866895005432	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
866895005433	active site
866895005434	catalytic site [active]
866895005435	substrate binding site [chemical binding]; other site
866895005436	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
866895005437	Sm and related proteins; Region: Sm_like; cl00259
866895005438	ribosome maturation protein RimP; Reviewed; Region: PRK00092
866895005439	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
866895005440	putative oligomer interface [polypeptide binding]; other site
866895005441	putative RNA binding site [nucleotide binding]; other site
866895005442	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
866895005443	NusA N-terminal domain; Region: NusA_N; pfam08529
866895005444	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
866895005445	RNA binding site [nucleotide binding]; other site
866895005446	homodimer interface [polypeptide binding]; other site
866895005447	NusA-like KH domain; Region: KH_5; pfam13184
866895005448	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
866895005449	G-X-X-G motif; other site
866895005450	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
866895005451	putative RNA binding cleft [nucleotide binding]; other site
866895005452	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
866895005453	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
866895005454	translation initiation factor IF-2; Region: IF-2; TIGR00487
866895005455	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
866895005456	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
866895005457	G1 box; other site
866895005458	putative GEF interaction site [polypeptide binding]; other site
866895005459	GTP/Mg2+ binding site [chemical binding]; other site
866895005460	Switch I region; other site
866895005461	G2 box; other site
866895005462	G3 box; other site
866895005463	Switch II region; other site
866895005464	G4 box; other site
866895005465	G5 box; other site
866895005466	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
866895005467	Translation-initiation factor 2; Region: IF-2; pfam11987
866895005468	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
866895005469	Protein of unknown function (DUF503); Region: DUF503; cl00669
866895005470	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
866895005471	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
866895005472	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
866895005473	RNA binding site [nucleotide binding]; other site
866895005474	active site
866895005475	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
866895005476	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
866895005477	active site
866895005478	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
866895005479	16S/18S rRNA binding site [nucleotide binding]; other site
866895005480	S13e-L30e interaction site [polypeptide binding]; other site
866895005481	25S rRNA binding site [nucleotide binding]; other site
866895005482	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
866895005483	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
866895005484	RNase E interface [polypeptide binding]; other site
866895005485	trimer interface [polypeptide binding]; other site
866895005486	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
866895005487	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
866895005488	RNase E interface [polypeptide binding]; other site
866895005489	trimer interface [polypeptide binding]; other site
866895005490	active site
866895005491	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
866895005492	putative nucleic acid binding region [nucleotide binding]; other site
866895005493	G-X-X-G motif; other site
866895005494	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
866895005495	RNA binding site [nucleotide binding]; other site
866895005496	domain interface; other site
866895005497	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
866895005498	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
866895005499	NodB motif; other site
866895005500	Protein implicated in RNA metabolism, contains PRC-barrel domain [General    function prediction only]; Region: COG1873; cl17889
866895005501	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
866895005502	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
866895005503	NAD binding site [chemical binding]; other site
866895005504	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
866895005505	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
866895005506	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
866895005507	aspartate kinase I; Reviewed; Region: PRK08210
866895005508	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
866895005509	nucleotide binding site [chemical binding]; other site
866895005510	substrate binding site [chemical binding]; other site
866895005511	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
866895005512	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
866895005513	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
866895005514	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
866895005515	dimer interface [polypeptide binding]; other site
866895005516	active site
866895005517	catalytic residue [active]
866895005518	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
866895005519	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
866895005520	active site
866895005521	YlzJ-like protein; Region: YlzJ; pfam14035
866895005522	Acyltransferase family; Region: Acyl_transf_3; pfam01757
866895005523	Membrane-associating domain; Region: MARVEL; pfam01284
866895005524	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
866895005525	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
866895005526	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
866895005527	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
866895005528	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895005529	DNA-binding site [nucleotide binding]; DNA binding site
866895005530	UTRA domain; Region: UTRA; pfam07702
866895005531	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
866895005532	ligand binding site [chemical binding]; other site
866895005533	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
866895005534	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
866895005535	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895005536	Walker A/P-loop; other site
866895005537	ATP binding site [chemical binding]; other site
866895005538	Q-loop/lid; other site
866895005539	ABC transporter signature motif; other site
866895005540	Walker B; other site
866895005541	D-loop; other site
866895005542	H-loop/switch region; other site
866895005543	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
866895005544	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866895005545	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
866895005546	TM-ABC transporter signature motif; other site
866895005547	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866895005548	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
866895005549	TM-ABC transporter signature motif; other site
866895005550	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
866895005551	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
866895005552	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
866895005553	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
866895005554	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
866895005555	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
866895005556	classical (c) SDRs; Region: SDR_c; cd05233
866895005557	NAD(P) binding site [chemical binding]; other site
866895005558	active site
866895005559	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
866895005560	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
866895005561	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
866895005562	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895005563	non-specific DNA binding site [nucleotide binding]; other site
866895005564	salt bridge; other site
866895005565	sequence-specific DNA binding site [nucleotide binding]; other site
866895005566	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
866895005567	competence damage-inducible protein A; Provisional; Region: PRK00549
866895005568	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
866895005569	putative MPT binding site; other site
866895005570	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
866895005571	recombinase A; Provisional; Region: recA; PRK09354
866895005572	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
866895005573	hexamer interface [polypeptide binding]; other site
866895005574	Walker A motif; other site
866895005575	ATP binding site [chemical binding]; other site
866895005576	Walker B motif; other site
866895005577	phosphodiesterase; Provisional; Region: PRK12704
866895005578	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866895005579	Zn2+ binding site [ion binding]; other site
866895005580	Mg2+ binding site [ion binding]; other site
866895005581	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
866895005582	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866895005583	putative active site [active]
866895005584	metal binding site [ion binding]; metal-binding site
866895005585	homodimer binding site [polypeptide binding]; other site
866895005586	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
866895005587	Threonine dehydrogenase; Region: TDH; cd05281
866895005588	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
866895005589	structural Zn binding site [ion binding]; other site
866895005590	catalytic Zn binding site [ion binding]; other site
866895005591	tetramer interface [polypeptide binding]; other site
866895005592	NADP binding site [chemical binding]; other site
866895005593	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
866895005594	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
866895005595	substrate-cofactor binding pocket; other site
866895005596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895005597	catalytic residue [active]
866895005598	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
866895005599	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
866895005600	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866895005601	FeS/SAM binding site; other site
866895005602	TRAM domain; Region: TRAM; pfam01938
866895005603	Predicted membrane protein [Function unknown]; Region: COG4550
866895005604	Outer spore coat protein E (CotE); Region: CotE; pfam10628
866895005605	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
866895005606	MutS domain I; Region: MutS_I; pfam01624
866895005607	MutS domain II; Region: MutS_II; pfam05188
866895005608	MutS domain III; Region: MutS_III; pfam05192
866895005609	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
866895005610	Walker A/P-loop; other site
866895005611	ATP binding site [chemical binding]; other site
866895005612	Q-loop/lid; other site
866895005613	ABC transporter signature motif; other site
866895005614	Walker B; other site
866895005615	D-loop; other site
866895005616	H-loop/switch region; other site
866895005617	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
866895005618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895005619	ATP binding site [chemical binding]; other site
866895005620	Mg2+ binding site [ion binding]; other site
866895005621	G-X-G motif; other site
866895005622	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
866895005623	ATP binding site [chemical binding]; other site
866895005624	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
866895005625	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866895005626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895005627	non-specific DNA binding site [nucleotide binding]; other site
866895005628	salt bridge; other site
866895005629	sequence-specific DNA binding site [nucleotide binding]; other site
866895005630	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
866895005631	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
866895005632	bacterial Hfq-like; Region: Hfq; cd01716
866895005633	hexamer interface [polypeptide binding]; other site
866895005634	Sm1 motif; other site
866895005635	RNA binding site [nucleotide binding]; other site
866895005636	Sm2 motif; other site
866895005637	stage V sporulation protein K; Region: spore_V_K; TIGR02881
866895005638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895005639	Walker A motif; other site
866895005640	ATP binding site [chemical binding]; other site
866895005641	Walker B motif; other site
866895005642	arginine finger; other site
866895005643	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
866895005644	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
866895005645	HflX GTPase family; Region: HflX; cd01878
866895005646	G1 box; other site
866895005647	GTP/Mg2+ binding site [chemical binding]; other site
866895005648	Switch I region; other site
866895005649	G2 box; other site
866895005650	G3 box; other site
866895005651	Switch II region; other site
866895005652	G4 box; other site
866895005653	G5 box; other site
866895005654	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
866895005655	Aluminium resistance protein; Region: Alum_res; pfam06838
866895005656	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
866895005657	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
866895005658	DNA binding residues [nucleotide binding]
866895005659	putative dimer interface [polypeptide binding]; other site
866895005660	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
866895005661	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
866895005662	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
866895005663	Helix-turn-helix domain; Region: HTH_17; pfam12728
866895005664	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
866895005665	Transposase; Region: DDE_Tnp_ISL3; pfam01610
866895005666	LexA repressor; Validated; Region: PRK00215
866895005667	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895005668	putative DNA binding site [nucleotide binding]; other site
866895005669	putative Zn2+ binding site [ion binding]; other site
866895005670	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
866895005671	Catalytic site [active]
866895005672	multiple promoter invertase; Provisional; Region: mpi; PRK13413
866895005673	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
866895005674	catalytic residues [active]
866895005675	catalytic nucleophile [active]
866895005676	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
866895005677	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
866895005678	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
866895005679	TPP-binding site [chemical binding]; other site
866895005680	dimer interface [polypeptide binding]; other site
866895005681	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866895005682	PYR/PP interface [polypeptide binding]; other site
866895005683	dimer interface [polypeptide binding]; other site
866895005684	TPP binding site [chemical binding]; other site
866895005685	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866895005686	hypothetical protein; Provisional; Region: PRK01844
866895005687	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
866895005688	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
866895005689	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
866895005690	Response regulator receiver domain; Region: Response_reg; pfam00072
866895005691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895005692	active site
866895005693	phosphorylation site [posttranslational modification]
866895005694	intermolecular recognition site; other site
866895005695	dimerization interface [polypeptide binding]; other site
866895005696	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
866895005697	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
866895005698	aconitate hydratase; Validated; Region: PRK09277
866895005699	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
866895005700	substrate binding site [chemical binding]; other site
866895005701	ligand binding site [chemical binding]; other site
866895005702	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
866895005703	substrate binding site [chemical binding]; other site
866895005704	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
866895005705	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866895005706	catalytic residues [active]
866895005707	Protein of unknown function (DUF3901); Region: DUF3901; pfam13040
866895005708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895005709	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895005710	Probable transposase; Region: OrfB_IS605; pfam01385
866895005711	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895005712	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
866895005713	stage V sporulation protein K; Region: spore_V_K; TIGR02881
866895005714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895005715	Walker A motif; other site
866895005716	ATP binding site [chemical binding]; other site
866895005717	Walker B motif; other site
866895005718	arginine finger; other site
866895005719	stage V sporulation protein K; Region: spore_V_K; TIGR02881
866895005720	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895005721	Walker A motif; other site
866895005722	ATP binding site [chemical binding]; other site
866895005723	Walker B motif; other site
866895005724	arginine finger; other site
866895005725	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
866895005726	active site
866895005727	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
866895005728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
866895005729	Haemolytic domain; Region: Haemolytic; pfam01809
866895005730	putative GTP cyclohydrolase; Provisional; Region: PRK13674
866895005731	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
866895005732	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
866895005733	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
866895005734	Walker A/P-loop; other site
866895005735	ATP binding site [chemical binding]; other site
866895005736	Q-loop/lid; other site
866895005737	ABC transporter signature motif; other site
866895005738	Walker B; other site
866895005739	D-loop; other site
866895005740	H-loop/switch region; other site
866895005741	CBS domain; Region: CBS; pfam00571
866895005742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895005743	dimer interface [polypeptide binding]; other site
866895005744	conserved gate region; other site
866895005745	ABC-ATPase subunit interface; other site
866895005746	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
866895005747	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
866895005748	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
866895005749	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
866895005750	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895005751	ATP binding site [chemical binding]; other site
866895005752	Mg2+ binding site [ion binding]; other site
866895005753	G-X-G motif; other site
866895005754	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
866895005755	anchoring element; other site
866895005756	dimer interface [polypeptide binding]; other site
866895005757	ATP binding site [chemical binding]; other site
866895005758	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
866895005759	active site
866895005760	putative metal-binding site [ion binding]; other site
866895005761	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
866895005762	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
866895005763	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
866895005764	CAP-like domain; other site
866895005765	active site
866895005766	primary dimer interface [polypeptide binding]; other site
866895005767	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866895005768	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866895005769	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895005770	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895005771	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
866895005772	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895005773	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
866895005774	FAD binding site [chemical binding]; other site
866895005775	homotetramer interface [polypeptide binding]; other site
866895005776	substrate binding pocket [chemical binding]; other site
866895005777	catalytic base [active]
866895005778	AMP-binding domain protein; Validated; Region: PRK08315
866895005779	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
866895005780	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
866895005781	acyl-activating enzyme (AAE) consensus motif; other site
866895005782	acyl-activating enzyme (AAE) consensus motif; other site
866895005783	putative AMP binding site [chemical binding]; other site
866895005784	putative active site [active]
866895005785	putative CoA binding site [chemical binding]; other site
866895005786	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
866895005787	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866895005788	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866895005789	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
866895005790	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866895005791	carboxyltransferase (CT) interaction site; other site
866895005792	biotinylation site [posttranslational modification]; other site
866895005793	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
866895005794	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
866895005795	active site
866895005796	catalytic residues [active]
866895005797	metal binding site [ion binding]; metal-binding site
866895005798	enoyl-CoA hydratase; Provisional; Region: PRK07657
866895005799	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866895005800	substrate binding site [chemical binding]; other site
866895005801	oxyanion hole (OAH) forming residues; other site
866895005802	trimer interface [polypeptide binding]; other site
866895005803	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
866895005804	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
866895005805	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
866895005806	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
866895005807	acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188
866895005808	Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968
866895005809	acyl-activating enzyme (AAE) consensus motif; other site
866895005810	putative AMP binding site [chemical binding]; other site
866895005811	putative active site [active]
866895005812	putative CoA binding site [chemical binding]; other site
866895005813	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
866895005814	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
866895005815	NAD binding site [chemical binding]; other site
866895005816	substrate binding site [chemical binding]; other site
866895005817	active site
866895005818	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895005819	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
866895005820	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
866895005821	Peptidase family M50; Region: Peptidase_M50; pfam02163
866895005822	active site
866895005823	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
866895005824	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
866895005825	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
866895005826	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
866895005827	active site
866895005828	catalytic site [active]
866895005829	substrate binding site [chemical binding]; other site
866895005830	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
866895005831	Dimer interface [polypeptide binding]; other site
866895005832	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
866895005833	putative FMN binding site [chemical binding]; other site
866895005834	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
866895005835	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895005836	Coenzyme A binding pocket [chemical binding]; other site
866895005837	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895005838	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
866895005839	active site
866895005840	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
866895005841	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
866895005842	siderophore binding site; other site
866895005843	methionine sulfoxide reductase B; Provisional; Region: PRK00222
866895005844	SelR domain; Region: SelR; pfam01641
866895005845	YusW-like protein; Region: YusW; pfam14039
866895005846	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
866895005847	S1 domain; Region: S1_2; pfam13509
866895005848	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
866895005849	RNA binding site [nucleotide binding]; other site
866895005850	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
866895005851	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
866895005852	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
866895005853	Transcriptional regulator PadR-like family; Region: PadR; cl17335
866895005854	Predicted transcriptional regulators [Transcription]; Region: COG1695
866895005855	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
866895005856	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
866895005857	putative NAD(P) binding site [chemical binding]; other site
866895005858	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895005859	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895005860	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
866895005861	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
866895005862	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895005863	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895005864	ABC transporter; Region: ABC_tran_2; pfam12848
866895005865	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895005866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
866895005867	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
866895005868	Cold-inducible protein YdjO; Region: YdjO; pfam14169
866895005869	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866895005870	DNA-binding site [nucleotide binding]; DNA binding site
866895005871	RNA-binding motif; other site
866895005872	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
866895005873	E-class dimer interface [polypeptide binding]; other site
866895005874	P-class dimer interface [polypeptide binding]; other site
866895005875	active site
866895005876	Cu2+ binding site [ion binding]; other site
866895005877	Zn2+ binding site [ion binding]; other site
866895005878	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
866895005879	Dynamin family; Region: Dynamin_N; pfam00350
866895005880	G1 box; other site
866895005881	GTP/Mg2+ binding site [chemical binding]; other site
866895005882	G2 box; other site
866895005883	Switch I region; other site
866895005884	G3 box; other site
866895005885	Switch II region; other site
866895005886	G4 box; other site
866895005887	G5 box; other site
866895005888	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
866895005889	Dynamin family; Region: Dynamin_N; pfam00350
866895005890	G1 box; other site
866895005891	GTP/Mg2+ binding site [chemical binding]; other site
866895005892	G2 box; other site
866895005893	Switch I region; other site
866895005894	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
866895005895	G3 box; other site
866895005896	Switch II region; other site
866895005897	G4 box; other site
866895005898	G5 box; other site
866895005899	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
866895005900	active site
866895005901	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
866895005902	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866895005903	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
866895005904	putative active site pocket [active]
866895005905	dimerization interface [polypeptide binding]; other site
866895005906	putative catalytic residue [active]
866895005907	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
866895005908	putative active site pocket [active]
866895005909	dimerization interface [polypeptide binding]; other site
866895005910	putative catalytic residue [active]
866895005911	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
866895005912	putative active site pocket [active]
866895005913	cleavage site
866895005914	Acylphosphatase; Region: Acylphosphatase; pfam00708
866895005915	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
866895005916	clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
866895005917	NADP binding site [chemical binding]; other site
866895005918	homotetramer interface [polypeptide binding]; other site
866895005919	homodimer interface [polypeptide binding]; other site
866895005920	active site
866895005921	4Fe-4S binding domain; Region: Fer4; pfam00037
866895005922	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866895005923	catalytic core [active]
866895005924	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
866895005925	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
866895005926	active site
866895005927	Predicted esterase [General function prediction only]; Region: COG0400
866895005928	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
866895005929	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
866895005930	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
866895005931	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
866895005932	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895005933	Coenzyme A binding pocket [chemical binding]; other site
866895005934	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895005935	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
866895005936	DNA-binding interface [nucleotide binding]; DNA binding site
866895005937	methionine sulfoxide reductase A; Provisional; Region: PRK14054
866895005938	methionine sulfoxide reductase B; Provisional; Region: PRK00222
866895005939	SelR domain; Region: SelR; pfam01641
866895005940	YqfQ-like protein; Region: YqfQ; pfam14181
866895005941	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
866895005942	ligand binding site [chemical binding]; other site
866895005943	active site
866895005944	UGI interface [polypeptide binding]; other site
866895005945	catalytic site [active]
866895005946	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
866895005947	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
866895005948	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
866895005949	Walker A/P-loop; other site
866895005950	ATP binding site [chemical binding]; other site
866895005951	Q-loop/lid; other site
866895005952	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
866895005953	ABC transporter signature motif; other site
866895005954	Walker B; other site
866895005955	D-loop; other site
866895005956	H-loop/switch region; other site
866895005957	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
866895005958	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
866895005959	active site
866895005960	metal binding site [ion binding]; metal-binding site
866895005961	DNA binding site [nucleotide binding]
866895005962	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
866895005963	hypothetical protein; Provisional; Region: PRK13672
866895005964	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
866895005965	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
866895005966	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
866895005967	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
866895005968	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
866895005969	GTP binding site; other site
866895005970	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
866895005971	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
866895005972	folate binding site [chemical binding]; other site
866895005973	NADP+ binding site [chemical binding]; other site
866895005974	thymidylate synthase; Region: thym_sym; TIGR03284
866895005975	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
866895005976	dimerization interface [polypeptide binding]; other site
866895005977	active site
866895005978	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
866895005979	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866895005980	Zn2+ binding site [ion binding]; other site
866895005981	Mg2+ binding site [ion binding]; other site
866895005982	Protein of unknown function DUF72; Region: DUF72; pfam01904
866895005983	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
866895005984	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
866895005985	Potassium binding sites [ion binding]; other site
866895005986	Cesium cation binding sites [ion binding]; other site
866895005987	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866895005988	DNA-binding site [nucleotide binding]; DNA binding site
866895005989	RNA-binding motif; other site
866895005990	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
866895005991	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
866895005992	RNA/DNA hybrid binding site [nucleotide binding]; other site
866895005993	active site
866895005994	Phospholipid methyltransferase; Region: PEMT; cl17370
866895005995	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
866895005996	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
866895005997	malonyl-CoA binding site [chemical binding]; other site
866895005998	dimer interface [polypeptide binding]; other site
866895005999	active site
866895006000	product binding site; other site
866895006001	tropinone reductase; Provisional; Region: PRK09242
866895006002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895006003	NAD(P) binding site [chemical binding]; other site
866895006004	active site
866895006005	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
866895006006	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
866895006007	active site
866895006008	Zn binding site [ion binding]; other site
866895006009	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
866895006010	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
866895006011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
866895006012	cell division protein GpsB; Provisional; Region: PRK14127
866895006013	DivIVA domain; Region: DivI1A_domain; TIGR03544
866895006014	hypothetical protein; Provisional; Region: PRK13660
866895006015	Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122
866895006016	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
866895006017	active site
866895006018	catalytic motif [active]
866895006019	Zn binding site [ion binding]; other site
866895006020	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
866895006021	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
866895006022	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
866895006023	Transglycosylase; Region: Transgly; pfam00912
866895006024	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
866895006025	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866895006026	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
866895006027	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866895006028	minor groove reading motif; other site
866895006029	helix-hairpin-helix signature motif; other site
866895006030	substrate binding pocket [chemical binding]; other site
866895006031	active site
866895006032	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
866895006033	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
866895006034	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
866895006035	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
866895006036	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
866895006037	putative dimer interface [polypeptide binding]; other site
866895006038	putative anticodon binding site; other site
866895006039	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
866895006040	homodimer interface [polypeptide binding]; other site
866895006041	motif 1; other site
866895006042	motif 2; other site
866895006043	active site
866895006044	motif 3; other site
866895006045	aspartate aminotransferase; Provisional; Region: PRK05764
866895006046	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866895006047	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895006048	homodimer interface [polypeptide binding]; other site
866895006049	catalytic residue [active]
866895006050	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
866895006051	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
866895006052	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
866895006053	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
866895006054	active site
866895006055	catalytic site [active]
866895006056	substrate binding site [chemical binding]; other site
866895006057	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
866895006058	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
866895006059	tetramerization interface [polypeptide binding]; other site
866895006060	active site
866895006061	pantoate--beta-alanine ligase; Region: panC; TIGR00018
866895006062	Pantoate-beta-alanine ligase; Region: PanC; cd00560
866895006063	active site
866895006064	ATP-binding site [chemical binding]; other site
866895006065	pantoate-binding site; other site
866895006066	HXXH motif; other site
866895006067	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
866895006068	oligomerization interface [polypeptide binding]; other site
866895006069	active site
866895006070	metal binding site [ion binding]; metal-binding site
866895006071	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895006072	putative DNA binding site [nucleotide binding]; other site
866895006073	putative Zn2+ binding site [ion binding]; other site
866895006074	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
866895006075	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
866895006076	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
866895006077	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
866895006078	active site
866895006079	NTP binding site [chemical binding]; other site
866895006080	metal binding triad [ion binding]; metal-binding site
866895006081	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
866895006082	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
866895006083	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
866895006084	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
866895006085	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
866895006086	active site
866895006087	dimer interfaces [polypeptide binding]; other site
866895006088	catalytic residues [active]
866895006089	dihydrodipicolinate reductase; Provisional; Region: PRK00048
866895006090	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
866895006091	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
866895006092	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
866895006093	homodimer interface [polypeptide binding]; other site
866895006094	metal binding site [ion binding]; metal-binding site
866895006095	Uncharacterized conserved protein [Function unknown]; Region: COG1284
866895006096	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
866895006097	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
866895006098	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
866895006099	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
866895006100	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
866895006101	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
866895006102	intrachain domain interface; other site
866895006103	Qi binding site; other site
866895006104	Qo binding site; other site
866895006105	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
866895006106	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
866895006107	cytochrome b6; Provisional; Region: PRK03735
866895006108	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
866895006109	interchain domain interface [polypeptide binding]; other site
866895006110	intrachain domain interface; other site
866895006111	heme bH binding site [chemical binding]; other site
866895006112	Qi binding site; other site
866895006113	heme bL binding site [chemical binding]; other site
866895006114	Qo binding site; other site
866895006115	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
866895006116	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
866895006117	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
866895006118	iron-sulfur cluster [ion binding]; other site
866895006119	[2Fe-2S] cluster binding site [ion binding]; other site
866895006120	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
866895006121	hypothetical protein; Provisional; Region: PRK03636
866895006122	UPF0302 domain; Region: UPF0302; pfam08864
866895006123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895006124	TPR motif; other site
866895006125	binding surface
866895006126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895006127	binding surface
866895006128	TPR motif; other site
866895006129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895006130	binding surface
866895006131	TPR motif; other site
866895006132	TPR repeat; Region: TPR_11; pfam13414
866895006133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895006134	TPR motif; other site
866895006135	binding surface
866895006136	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
866895006137	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
866895006138	hinge; other site
866895006139	active site
866895006140	prephenate dehydrogenase; Validated; Region: PRK08507
866895006141	prephenate dehydrogenase; Validated; Region: PRK06545
866895006142	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
866895006143	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
866895006144	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866895006145	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895006146	homodimer interface [polypeptide binding]; other site
866895006147	catalytic residue [active]
866895006148	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
866895006149	homotrimer interaction site [polypeptide binding]; other site
866895006150	active site
866895006151	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
866895006152	active site
866895006153	dimer interface [polypeptide binding]; other site
866895006154	metal binding site [ion binding]; metal-binding site
866895006155	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
866895006156	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
866895006157	Tetramer interface [polypeptide binding]; other site
866895006158	active site
866895006159	FMN-binding site [chemical binding]; other site
866895006160	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
866895006161	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
866895006162	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
866895006163	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
866895006164	active site
866895006165	multimer interface [polypeptide binding]; other site
866895006166	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
866895006167	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
866895006168	substrate binding pocket [chemical binding]; other site
866895006169	chain length determination region; other site
866895006170	substrate-Mg2+ binding site; other site
866895006171	catalytic residues [active]
866895006172	aspartate-rich region 1; other site
866895006173	active site lid residues [active]
866895006174	aspartate-rich region 2; other site
866895006175	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
866895006176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895006177	S-adenosylmethionine binding site [chemical binding]; other site
866895006178	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
866895006179	transcription attenuation protein MtrB; Provisional; Region: PRK13251
866895006180	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
866895006181	IHF dimer interface [polypeptide binding]; other site
866895006182	IHF - DNA interface [nucleotide binding]; other site
866895006183	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
866895006184	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
866895006185	Protein of unknown function (DUF2768); Region: DUF2768; pfam10966
866895006186	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
866895006187	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
866895006188	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
866895006189	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
866895006190	GTP-binding protein Der; Reviewed; Region: PRK00093
866895006191	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
866895006192	G1 box; other site
866895006193	GTP/Mg2+ binding site [chemical binding]; other site
866895006194	Switch I region; other site
866895006195	G2 box; other site
866895006196	Switch II region; other site
866895006197	G3 box; other site
866895006198	G4 box; other site
866895006199	G5 box; other site
866895006200	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
866895006201	G1 box; other site
866895006202	GTP/Mg2+ binding site [chemical binding]; other site
866895006203	Switch I region; other site
866895006204	G2 box; other site
866895006205	G3 box; other site
866895006206	Switch II region; other site
866895006207	G4 box; other site
866895006208	G5 box; other site
866895006209	YIEGIA protein; Region: YIEGIA; pfam14045
866895006210	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
866895006211	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
866895006212	homotetramer interface [polypeptide binding]; other site
866895006213	FMN binding site [chemical binding]; other site
866895006214	homodimer contacts [polypeptide binding]; other site
866895006215	putative active site [active]
866895006216	putative substrate binding site [chemical binding]; other site
866895006217	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
866895006218	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
866895006219	RNA binding site [nucleotide binding]; other site
866895006220	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
866895006221	RNA binding site [nucleotide binding]; other site
866895006222	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
866895006223	RNA binding site [nucleotide binding]; other site
866895006224	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
866895006225	RNA binding site [nucleotide binding]; other site
866895006226	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
866895006227	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
866895006228	putative acyl-acceptor binding pocket; other site
866895006229	cytidylate kinase; Provisional; Region: cmk; PRK00023
866895006230	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
866895006231	CMP-binding site; other site
866895006232	The sites determining sugar specificity; other site
866895006233	Flagellar protein YcgR; Region: YcgR_2; pfam12945
866895006234	PilZ domain; Region: PilZ; pfam07238
866895006235	germination protein YpeB; Region: spore_YpeB; TIGR02889
866895006236	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
866895006237	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
866895006238	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
866895006239	Protease prsW family; Region: PrsW-protease; pfam13367
866895006240	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
866895006241	active site
866895006242	homotetramer interface [polypeptide binding]; other site
866895006243	homodimer interface [polypeptide binding]; other site
866895006244	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
866895006245	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
866895006246	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
866895006247	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
866895006248	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
866895006249	NAD(P) binding site [chemical binding]; other site
866895006250	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
866895006251	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
866895006252	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866895006253	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
866895006254	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
866895006255	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
866895006256	DNA binding residues [nucleotide binding]
866895006257	B12 binding domain; Region: B12-binding_2; pfam02607
866895006258	B12 binding domain; Region: B12-binding; pfam02310
866895006259	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
866895006260	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866895006261	active site
866895006262	metal binding site [ion binding]; metal-binding site
866895006263	FOG: CBS domain [General function prediction only]; Region: COG0517
866895006264	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
866895006265	CotJB protein; Region: CotJB; pfam12652
866895006266	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
866895006267	dimanganese center [ion binding]; other site
866895006268	CAAX protease self-immunity; Region: Abi; pfam02517
866895006269	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866895006270	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895006271	ATP binding site [chemical binding]; other site
866895006272	putative Mg++ binding site [ion binding]; other site
866895006273	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895006274	nucleotide binding region [chemical binding]; other site
866895006275	ATP-binding site [chemical binding]; other site
866895006276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
866895006277	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
866895006278	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866895006279	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895006280	non-specific DNA binding site [nucleotide binding]; other site
866895006281	salt bridge; other site
866895006282	sequence-specific DNA binding site [nucleotide binding]; other site
866895006283	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
866895006284	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895006285	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895006286	DNA binding residues [nucleotide binding]
866895006287	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
866895006288	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
866895006289	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
866895006290	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866895006291	dimerization interface [polypeptide binding]; other site
866895006292	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866895006293	dimer interface [polypeptide binding]; other site
866895006294	phosphorylation site [posttranslational modification]
866895006295	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895006296	ATP binding site [chemical binding]; other site
866895006297	Mg2+ binding site [ion binding]; other site
866895006298	G-X-G motif; other site
866895006299	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866895006300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895006301	active site
866895006302	phosphorylation site [posttranslational modification]
866895006303	intermolecular recognition site; other site
866895006304	dimerization interface [polypeptide binding]; other site
866895006305	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866895006306	DNA binding site [nucleotide binding]
866895006307	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
866895006308	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
866895006309	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
866895006310	ResB-like family; Region: ResB; pfam05140
866895006311	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
866895006312	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866895006313	catalytic residues [active]
866895006314	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
866895006315	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866895006316	RNA binding surface [nucleotide binding]; other site
866895006317	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
866895006318	active site
866895006319	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
866895006320	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
866895006321	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
866895006322	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
866895006323	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
866895006324	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
866895006325	Domain of unknown function (DUF309); Region: DUF309; pfam03745
866895006326	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895006327	Coenzyme A binding pocket [chemical binding]; other site
866895006328	Peptidase family M50; Region: Peptidase_M50; pfam02163
866895006329	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
866895006330	active site
866895006331	diaminopimelate decarboxylase; Region: lysA; TIGR01048
866895006332	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
866895006333	active site
866895006334	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866895006335	substrate binding site [chemical binding]; other site
866895006336	catalytic residues [active]
866895006337	dimer interface [polypeptide binding]; other site
866895006338	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
866895006339	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
866895006340	stage V sporulation protein AD; Validated; Region: PRK08304
866895006341	stage V sporulation protein AD; Provisional; Region: PRK12404
866895006342	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
866895006343	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
866895006344	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
866895006345	sporulation sigma factor SigF; Validated; Region: PRK05572
866895006346	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895006347	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
866895006348	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895006349	DNA binding residues [nucleotide binding]
866895006350	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
866895006351	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895006352	ATP binding site [chemical binding]; other site
866895006353	Mg2+ binding site [ion binding]; other site
866895006354	G-X-G motif; other site
866895006355	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
866895006356	anti sigma factor interaction site; other site
866895006357	regulatory phosphorylation site [posttranslational modification]; other site
866895006358	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
866895006359	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
866895006360	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
866895006361	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
866895006362	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
866895006363	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
866895006364	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
866895006365	purine nucleoside phosphorylase; Provisional; Region: PRK08202
866895006366	phosphopentomutase; Provisional; Region: PRK05362
866895006367	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
866895006368	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
866895006369	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
866895006370	active site
866895006371	Int/Topo IB signature motif; other site
866895006372	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
866895006373	metal binding site 2 [ion binding]; metal-binding site
866895006374	putative DNA binding helix; other site
866895006375	metal binding site 1 [ion binding]; metal-binding site
866895006376	dimer interface [polypeptide binding]; other site
866895006377	structural Zn2+ binding site [ion binding]; other site
866895006378	Integral membrane protein DUF95; Region: DUF95; cl00572
866895006379	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
866895006380	dimer interface [polypeptide binding]; other site
866895006381	ADP-ribose binding site [chemical binding]; other site
866895006382	active site
866895006383	nudix motif; other site
866895006384	metal binding site [ion binding]; metal-binding site
866895006385	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895006386	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895006387	active site
866895006388	catalytic tetrad [active]
866895006389	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
866895006390	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
866895006391	active site
866895006392	dimer interface [polypeptide binding]; other site
866895006393	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895006394	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
866895006395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895006396	putative substrate translocation pore; other site
866895006397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895006398	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
866895006399	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895006400	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866895006401	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866895006402	peptide binding site [polypeptide binding]; other site
866895006403	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
866895006404	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
866895006405	tandem repeat interface [polypeptide binding]; other site
866895006406	oligomer interface [polypeptide binding]; other site
866895006407	active site residues [active]
866895006408	RDD family; Region: RDD; pfam06271
866895006409	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
866895006410	Cytochrome P450; Region: p450; cl12078
866895006411	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866895006412	Helix-turn-helix domain; Region: HTH_28; pfam13518
866895006413	putative transposase OrfB; Reviewed; Region: PHA02517
866895006414	HTH-like domain; Region: HTH_21; pfam13276
866895006415	Integrase core domain; Region: rve; pfam00665
866895006416	Integrase core domain; Region: rve_2; pfam13333
866895006417	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
866895006418	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828
866895006419	active site
866895006420	catalytic site [active]
866895006421	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
866895006422	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
866895006423	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
866895006424	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895006425	Transcriptional regulators [Transcription]; Region: FadR; COG2186
866895006426	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895006427	DNA-binding site [nucleotide binding]; DNA binding site
866895006428	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
866895006429	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
866895006430	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
866895006431	classical (c) SDRs; Region: SDR_c; cd05233
866895006432	NAD(P) binding site [chemical binding]; other site
866895006433	active site
866895006434	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
866895006435	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
866895006436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895006437	ABC-ATPase subunit interface; other site
866895006438	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
866895006439	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
866895006440	Walker A/P-loop; other site
866895006441	ATP binding site [chemical binding]; other site
866895006442	Q-loop/lid; other site
866895006443	ABC transporter signature motif; other site
866895006444	Walker B; other site
866895006445	D-loop; other site
866895006446	H-loop/switch region; other site
866895006447	NIL domain; Region: NIL; pfam09383
866895006448	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
866895006449	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
866895006450	putative active site [active]
866895006451	metal binding site [ion binding]; metal-binding site
866895006452	EamA-like transporter family; Region: EamA; pfam00892
866895006453	EamA-like transporter family; Region: EamA; pfam00892
866895006454	Nitronate monooxygenase; Region: NMO; pfam03060
866895006455	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
866895006456	FMN binding site [chemical binding]; other site
866895006457	substrate binding site [chemical binding]; other site
866895006458	putative catalytic residue [active]
866895006459	Excalibur calcium-binding domain; Region: Excalibur; cl05460
866895006460	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
866895006461	Protein of unknown function (DUF4257); Region: DUF4257; pfam14074
866895006462	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
866895006463	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
866895006464	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895006465	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895006466	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866895006467	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
866895006468	hypothetical protein; Validated; Region: PRK07708
866895006469	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
866895006470	RNA/DNA hybrid binding site [nucleotide binding]; other site
866895006471	active site
866895006472	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
866895006473	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
866895006474	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
866895006475	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
866895006476	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
866895006477	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895006478	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895006479	ABC transporter; Region: ABC_tran_2; pfam12848
866895006480	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895006481	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895006482	Coenzyme A binding pocket [chemical binding]; other site
866895006483	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895006484	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895006485	Coenzyme A binding pocket [chemical binding]; other site
866895006486	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
866895006487	Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002
866895006488	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
866895006489	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895006490	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
866895006491	active site
866895006492	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
866895006493	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
866895006494	ATP binding site [chemical binding]; other site
866895006495	substrate interface [chemical binding]; other site
866895006496	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
866895006497	ThiS interaction site; other site
866895006498	putative active site [active]
866895006499	tetramer interface [polypeptide binding]; other site
866895006500	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
866895006501	thiS-thiF/thiG interaction site; other site
866895006502	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
866895006503	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
866895006504	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
866895006505	thiamine phosphate binding site [chemical binding]; other site
866895006506	active site
866895006507	pyrophosphate binding site [ion binding]; other site
866895006508	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
866895006509	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
866895006510	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
866895006511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
866895006512	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895006513	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
866895006514	NAD(P) binding site [chemical binding]; other site
866895006515	active site
866895006516	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866895006517	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
866895006518	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
866895006519	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
866895006520	metal binding site [ion binding]; metal-binding site
866895006521	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
866895006522	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
866895006523	active site
866895006524	catalytic site [active]
866895006525	metal binding site [ion binding]; metal-binding site
866895006526	dimer interface [polypeptide binding]; other site
866895006527	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
866895006528	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866895006529	active site
866895006530	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
866895006531	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
866895006532	active site
866895006533	FMN binding site [chemical binding]; other site
866895006534	substrate binding site [chemical binding]; other site
866895006535	homotetramer interface [polypeptide binding]; other site
866895006536	catalytic residue [active]
866895006537	ribonuclease Z; Region: RNase_Z; TIGR02651
866895006538	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
866895006539	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
866895006540	NAD(P) binding site [chemical binding]; other site
866895006541	catalytic residues [active]
866895006542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895006543	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895006544	Probable transposase; Region: OrfB_IS605; pfam01385
866895006545	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895006546	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
866895006547	LysE type translocator; Region: LysE; pfam01810
866895006548	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
866895006549	YpzI-like protein; Region: YpzI; pfam14140
866895006550	DNA polymerase IV; Validated; Region: PRK01810
866895006551	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
866895006552	active site
866895006553	DNA binding site [nucleotide binding]
866895006554	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
866895006555	peptidase T-like protein; Region: PepT-like; TIGR01883
866895006556	metal binding site [ion binding]; metal-binding site
866895006557	putative dimer interface [polypeptide binding]; other site
866895006558	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
866895006559	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
866895006560	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
866895006561	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
866895006562	B12 binding site [chemical binding]; other site
866895006563	cobalt ligand [ion binding]; other site
866895006564	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895006565	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
866895006566	dimer interface [polypeptide binding]; other site
866895006567	substrate binding site [chemical binding]; other site
866895006568	metal binding site [ion binding]; metal-binding site
866895006569	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
866895006570	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866895006571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
866895006572	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895006573	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895006574	Probable transposase; Region: OrfB_IS605; pfam01385
866895006575	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895006576	Predicted membrane protein [Function unknown]; Region: COG4129
866895006577	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
866895006578	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
866895006579	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
866895006580	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
866895006581	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866895006582	E3 interaction surface; other site
866895006583	lipoyl attachment site [posttranslational modification]; other site
866895006584	e3 binding domain; Region: E3_binding; pfam02817
866895006585	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
866895006586	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
866895006587	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
866895006588	alpha subunit interface [polypeptide binding]; other site
866895006589	TPP binding site [chemical binding]; other site
866895006590	heterodimer interface [polypeptide binding]; other site
866895006591	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866895006592	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
866895006593	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
866895006594	tetramer interface [polypeptide binding]; other site
866895006595	TPP-binding site [chemical binding]; other site
866895006596	heterodimer interface [polypeptide binding]; other site
866895006597	phosphorylation loop region [posttranslational modification]
866895006598	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
866895006599	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895006600	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866895006601	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866895006602	nucleotide binding site [chemical binding]; other site
866895006603	Acetokinase family; Region: Acetate_kinase; cl17229
866895006604	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
866895006605	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
866895006606	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
866895006607	NAD binding site [chemical binding]; other site
866895006608	Phe binding site; other site
866895006609	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
866895006610	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
866895006611	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895006612	putative active site [active]
866895006613	heme pocket [chemical binding]; other site
866895006614	PAS domain; Region: PAS; smart00091
866895006615	putative active site [active]
866895006616	heme pocket [chemical binding]; other site
866895006617	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895006618	Walker A motif; other site
866895006619	ATP binding site [chemical binding]; other site
866895006620	Walker B motif; other site
866895006621	arginine finger; other site
866895006622	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
866895006623	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
866895006624	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
866895006625	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
866895006626	ligand binding site [chemical binding]; other site
866895006627	flexible hinge region; other site
866895006628	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
866895006629	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
866895006630	metal binding triad; other site
866895006631	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
866895006632	active site
866895006633	catalytic site [active]
866895006634	substrate binding site [chemical binding]; other site
866895006635	aspartate kinase; Reviewed; Region: PRK09034
866895006636	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
866895006637	nucleotide binding site [chemical binding]; other site
866895006638	substrate binding site [chemical binding]; other site
866895006639	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
866895006640	allosteric regulatory residue; other site
866895006641	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
866895006642	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
866895006643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895006644	active site
866895006645	phosphorylation site [posttranslational modification]
866895006646	intermolecular recognition site; other site
866895006647	dimerization interface [polypeptide binding]; other site
866895006648	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
866895006649	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
866895006650	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
866895006651	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
866895006652	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
866895006653	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
866895006654	Walker A/P-loop; other site
866895006655	ATP binding site [chemical binding]; other site
866895006656	Q-loop/lid; other site
866895006657	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
866895006658	ABC transporter signature motif; other site
866895006659	Walker B; other site
866895006660	D-loop; other site
866895006661	H-loop/switch region; other site
866895006662	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
866895006663	arginine repressor; Provisional; Region: PRK04280
866895006664	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
866895006665	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
866895006666	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866895006667	RNA binding surface [nucleotide binding]; other site
866895006668	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
866895006669	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
866895006670	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
866895006671	TPP-binding site; other site
866895006672	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866895006673	PYR/PP interface [polypeptide binding]; other site
866895006674	dimer interface [polypeptide binding]; other site
866895006675	TPP binding site [chemical binding]; other site
866895006676	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866895006677	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
866895006678	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
866895006679	substrate binding pocket [chemical binding]; other site
866895006680	chain length determination region; other site
866895006681	substrate-Mg2+ binding site; other site
866895006682	catalytic residues [active]
866895006683	aspartate-rich region 1; other site
866895006684	active site lid residues [active]
866895006685	aspartate-rich region 2; other site
866895006686	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
866895006687	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
866895006688	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
866895006689	generic binding surface II; other site
866895006690	generic binding surface I; other site
866895006691	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
866895006692	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
866895006693	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
866895006694	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
866895006695	homodimer interface [polypeptide binding]; other site
866895006696	NADP binding site [chemical binding]; other site
866895006697	substrate binding site [chemical binding]; other site
866895006698	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
866895006699	putative RNA binding site [nucleotide binding]; other site
866895006700	Asp23 family; Region: Asp23; pfam03780
866895006701	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
866895006702	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866895006703	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
866895006704	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
866895006705	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
866895006706	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866895006707	carboxyltransferase (CT) interaction site; other site
866895006708	biotinylation site [posttranslational modification]; other site
866895006709	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
866895006710	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
866895006711	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
866895006712	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
866895006713	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
866895006714	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
866895006715	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
866895006716	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
866895006717	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895006718	Walker A/P-loop; other site
866895006719	ATP binding site [chemical binding]; other site
866895006720	ABC transporter signature motif; other site
866895006721	Walker B; other site
866895006722	D-loop; other site
866895006723	H-loop/switch region; other site
866895006724	elongation factor P; Validated; Region: PRK00529
866895006725	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
866895006726	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
866895006727	RNA binding site [nucleotide binding]; other site
866895006728	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
866895006729	RNA binding site [nucleotide binding]; other site
866895006730	potential frameshift: common BLAST hit: gi|319767459|ref|YP_004132960.1| peptidase M24
866895006731	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
866895006732	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
866895006733	active site
866895006734	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
866895006735	Dehydroquinase class II; Region: DHquinase_II; pfam01220
866895006736	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
866895006737	trimer interface [polypeptide binding]; other site
866895006738	active site
866895006739	dimer interface [polypeptide binding]; other site
866895006740	Conserved membrane protein YqhR; Region: YqhR; pfam11085
866895006741	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
866895006742	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
866895006743	active site
866895006744	nucleophile elbow; other site
866895006745	manganese transport transcriptional regulator; Provisional; Region: PRK03902
866895006746	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
866895006747	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
866895006748	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
866895006749	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
866895006750	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
866895006751	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
866895006752	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866895006753	active site residue [active]
866895006754	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
866895006755	tetramer interface [polypeptide binding]; other site
866895006756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895006757	catalytic residue [active]
866895006758	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
866895006759	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
866895006760	tetramer interface [polypeptide binding]; other site
866895006761	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895006762	catalytic residue [active]
866895006763	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
866895006764	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
866895006765	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866895006766	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895006767	ATP binding site [chemical binding]; other site
866895006768	putative Mg++ binding site [ion binding]; other site
866895006769	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895006770	nucleotide binding region [chemical binding]; other site
866895006771	ATP-binding site [chemical binding]; other site
866895006772	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
866895006773	YqzE-like protein; Region: YqzE; pfam14038
866895006774	shikimate kinase; Reviewed; Region: aroK; PRK00131
866895006775	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
866895006776	ADP binding site [chemical binding]; other site
866895006777	magnesium binding site [ion binding]; other site
866895006778	putative shikimate binding site; other site
866895006779	Type II/IV secretion system protein; Region: T2SE; pfam00437
866895006780	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866895006781	Walker A motif; other site
866895006782	ATP binding site [chemical binding]; other site
866895006783	Walker B motif; other site
866895006784	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
866895006785	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
866895006786	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
866895006787	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
866895006788	ArsC family; Region: ArsC; pfam03960
866895006789	putative catalytic residues [active]
866895006790	thiol/disulfide switch; other site
866895006791	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
866895006792	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866895006793	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
866895006794	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
866895006795	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
866895006796	Walker A/P-loop; other site
866895006797	ATP binding site [chemical binding]; other site
866895006798	Q-loop/lid; other site
866895006799	ABC transporter signature motif; other site
866895006800	Walker B; other site
866895006801	D-loop; other site
866895006802	H-loop/switch region; other site
866895006803	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
866895006804	Sulfatase; Region: Sulfatase; pfam00884
866895006805	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
866895006806	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866895006807	nucleotide binding site [chemical binding]; other site
866895006808	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
866895006809	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
866895006810	Rhomboid family; Region: Rhomboid; pfam01694
866895006811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895006812	binding surface
866895006813	TPR motif; other site
866895006814	TPR repeat; Region: TPR_11; pfam13414
866895006815	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
866895006816	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
866895006817	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866895006818	NAD binding site [chemical binding]; other site
866895006819	dimer interface [polypeptide binding]; other site
866895006820	substrate binding site [chemical binding]; other site
866895006821	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
866895006822	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
866895006823	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
866895006824	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
866895006825	PhoU domain; Region: PhoU; pfam01895
866895006826	PhoU domain; Region: PhoU; pfam01895
866895006827	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
866895006828	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
866895006829	Walker A/P-loop; other site
866895006830	ATP binding site [chemical binding]; other site
866895006831	Q-loop/lid; other site
866895006832	ABC transporter signature motif; other site
866895006833	Walker B; other site
866895006834	D-loop; other site
866895006835	H-loop/switch region; other site
866895006836	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
866895006837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895006838	dimer interface [polypeptide binding]; other site
866895006839	conserved gate region; other site
866895006840	putative PBP binding loops; other site
866895006841	ABC-ATPase subunit interface; other site
866895006842	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
866895006843	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895006844	dimer interface [polypeptide binding]; other site
866895006845	conserved gate region; other site
866895006846	putative PBP binding loops; other site
866895006847	ABC-ATPase subunit interface; other site
866895006848	PBP superfamily domain; Region: PBP_like_2; cl17296
866895006849	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
866895006850	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866895006851	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866895006852	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895006853	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895006854	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
866895006855	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
866895006856	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
866895006857	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
866895006858	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
866895006859	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
866895006860	PhoU domain; Region: PhoU; pfam01895
866895006861	PhoU domain; Region: PhoU; pfam01895
866895006862	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
866895006863	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
866895006864	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
866895006865	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
866895006866	Protein of unknown function (DUF2624); Region: DUF2624; pfam11116
866895006867	endonuclease IV; Provisional; Region: PRK01060
866895006868	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
866895006869	AP (apurinic/apyrimidinic) site pocket; other site
866895006870	DNA interaction; other site
866895006871	Metal-binding active site; metal-binding site
866895006872	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866895006873	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866895006874	ATP binding site [chemical binding]; other site
866895006875	Mg++ binding site [ion binding]; other site
866895006876	motif III; other site
866895006877	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895006878	nucleotide binding region [chemical binding]; other site
866895006879	ATP-binding site [chemical binding]; other site
866895006880	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
866895006881	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
866895006882	Uncharacterized conserved protein [Function unknown]; Region: COG0327
866895006883	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
866895006884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
866895006885	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
866895006886	Uncharacterized conserved protein [Function unknown]; Region: COG0327
866895006887	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
866895006888	Family of unknown function (DUF633); Region: DUF633; pfam04816
866895006889	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
866895006890	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
866895006891	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
866895006892	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
866895006893	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
866895006894	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895006895	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
866895006896	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895006897	DNA binding residues [nucleotide binding]
866895006898	DNA primase; Validated; Region: dnaG; PRK05667
866895006899	CHC2 zinc finger; Region: zf-CHC2; pfam01807
866895006900	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
866895006901	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
866895006902	active site
866895006903	metal binding site [ion binding]; metal-binding site
866895006904	interdomain interaction site; other site
866895006905	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
866895006906	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
866895006907	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
866895006908	HTH domain; Region: HTH_11; pfam08279
866895006909	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
866895006910	FOG: CBS domain [General function prediction only]; Region: COG0517
866895006911	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
866895006912	DALR anticodon binding domain; Region: DALR_1; pfam05746
866895006913	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
866895006914	dimer interface [polypeptide binding]; other site
866895006915	motif 1; other site
866895006916	active site
866895006917	motif 2; other site
866895006918	motif 3; other site
866895006919	Recombination protein O N terminal; Region: RecO_N; pfam11967
866895006920	DNA repair protein RecO; Region: reco; TIGR00613
866895006921	Recombination protein O C terminal; Region: RecO_C; pfam02565
866895006922	YqzL-like protein; Region: YqzL; pfam14006
866895006923	GTPase Era; Reviewed; Region: era; PRK00089
866895006924	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
866895006925	G1 box; other site
866895006926	GTP/Mg2+ binding site [chemical binding]; other site
866895006927	Switch I region; other site
866895006928	G2 box; other site
866895006929	Switch II region; other site
866895006930	G3 box; other site
866895006931	G4 box; other site
866895006932	G5 box; other site
866895006933	KH domain; Region: KH_2; pfam07650
866895006934	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
866895006935	metal-binding heat shock protein; Provisional; Region: PRK00016
866895006936	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
866895006937	PhoH-like protein; Region: PhoH; pfam02562
866895006938	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
866895006939	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
866895006940	YabP family; Region: YabP; cl06766
866895006941	hypothetical protein; Provisional; Region: PRK13665
866895006942	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
866895006943	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
866895006944	dimer interface [polypeptide binding]; other site
866895006945	active site residues [active]
866895006946	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
866895006947	Yqey-like protein; Region: YqeY; pfam09424
866895006948	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
866895006949	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
866895006950	intersubunit interface [polypeptide binding]; other site
866895006951	active site
866895006952	catalytic residue [active]
866895006953	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
866895006954	RNA methyltransferase, RsmE family; Region: TIGR00046
866895006955	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
866895006956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895006957	S-adenosylmethionine binding site [chemical binding]; other site
866895006958	chaperone protein DnaJ; Provisional; Region: PRK14280
866895006959	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
866895006960	HSP70 interaction site [polypeptide binding]; other site
866895006961	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
866895006962	substrate binding site [polypeptide binding]; other site
866895006963	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
866895006964	Zn binding sites [ion binding]; other site
866895006965	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
866895006966	dimer interface [polypeptide binding]; other site
866895006967	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
866895006968	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
866895006969	nucleotide binding site [chemical binding]; other site
866895006970	NEF interaction site [polypeptide binding]; other site
866895006971	SBD interface [polypeptide binding]; other site
866895006972	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
866895006973	dimer interface [polypeptide binding]; other site
866895006974	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
866895006975	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
866895006976	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
866895006977	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
866895006978	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866895006979	FeS/SAM binding site; other site
866895006980	HemN C-terminal domain; Region: HemN_C; pfam06969
866895006981	GTP-binding protein LepA; Provisional; Region: PRK05433
866895006982	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
866895006983	G1 box; other site
866895006984	putative GEF interaction site [polypeptide binding]; other site
866895006985	GTP/Mg2+ binding site [chemical binding]; other site
866895006986	Switch I region; other site
866895006987	G2 box; other site
866895006988	G3 box; other site
866895006989	Switch II region; other site
866895006990	G4 box; other site
866895006991	G5 box; other site
866895006992	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
866895006993	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
866895006994	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
866895006995	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
866895006996	stage II sporulation protein P; Region: spore_II_P; TIGR02867
866895006997	germination protease; Provisional; Region: PRK02858
866895006998	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
866895006999	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
866895007000	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
866895007001	YqzM-like protein; Region: YqzM; pfam14141
866895007002	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
866895007003	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
866895007004	Competence protein; Region: Competence; pfam03772
866895007005	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866895007006	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
866895007007	catalytic motif [active]
866895007008	Zn binding site [ion binding]; other site
866895007009	Transcriptional regulator; Region: Transcrip_reg; cl00361
866895007010	comEA protein; Region: comE; TIGR01259
866895007011	Helix-hairpin-helix motif; Region: HHH; pfam00633
866895007012	late competence protein ComER; Validated; Region: PRK07680
866895007013	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
866895007014	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
866895007015	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
866895007016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895007017	S-adenosylmethionine binding site [chemical binding]; other site
866895007018	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
866895007019	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866895007020	Zn2+ binding site [ion binding]; other site
866895007021	Mg2+ binding site [ion binding]; other site
866895007022	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
866895007023	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
866895007024	active site
866895007025	(T/H)XGH motif; other site
866895007026	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
866895007027	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
866895007028	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
866895007029	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
866895007030	shikimate binding site; other site
866895007031	NAD(P) binding site [chemical binding]; other site
866895007032	GTPase YqeH; Provisional; Region: PRK13796
866895007033	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
866895007034	GTP/Mg2+ binding site [chemical binding]; other site
866895007035	G4 box; other site
866895007036	G5 box; other site
866895007037	G1 box; other site
866895007038	Switch I region; other site
866895007039	G2 box; other site
866895007040	G3 box; other site
866895007041	Switch II region; other site
866895007042	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
866895007043	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895007044	active site
866895007045	motif I; other site
866895007046	motif II; other site
866895007047	Sporulation inhibitor A; Region: Sda; pfam08970
866895007048	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
866895007049	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
866895007050	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
866895007051	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
866895007052	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
866895007053	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
866895007054	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
866895007055	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
866895007056	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
866895007057	sporulation sigma factor SigK; Reviewed; Region: PRK05803
866895007058	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895007059	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895007060	DNA binding residues [nucleotide binding]
866895007061	YrhC-like protein; Region: YrhC; pfam14143
866895007062	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
866895007063	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
866895007064	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
866895007065	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
866895007066	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
866895007067	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
866895007068	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
866895007069	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
866895007070	ATP-binding site [chemical binding]; other site
866895007071	Sugar specificity; other site
866895007072	Pyrimidine base specificity; other site
866895007073	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
866895007074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895007075	S-adenosylmethionine binding site [chemical binding]; other site
866895007076	YceG-like family; Region: YceG; pfam02618
866895007077	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
866895007078	dimerization interface [polypeptide binding]; other site
866895007079	hypothetical protein; Provisional; Region: PRK13678
866895007080	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
866895007081	hypothetical protein; Provisional; Region: PRK05473
866895007082	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
866895007083	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
866895007084	motif 1; other site
866895007085	active site
866895007086	motif 2; other site
866895007087	motif 3; other site
866895007088	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
866895007089	DHHA1 domain; Region: DHHA1; pfam02272
866895007090	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
866895007091	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866895007092	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
866895007093	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
866895007094	AAA domain; Region: AAA_30; pfam13604
866895007095	Family description; Region: UvrD_C_2; pfam13538
866895007096	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895007097	binding surface
866895007098	TPR repeat; Region: TPR_11; pfam13414
866895007099	TPR motif; other site
866895007100	TPR repeat; Region: TPR_11; pfam13414
866895007101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895007102	binding surface
866895007103	TPR motif; other site
866895007104	TPR repeat; Region: TPR_11; pfam13414
866895007105	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
866895007106	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
866895007107	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
866895007108	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
866895007109	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866895007110	catalytic residue [active]
866895007111	Predicted transcriptional regulator [Transcription]; Region: COG1959
866895007112	Transcriptional regulator; Region: Rrf2; pfam02082
866895007113	Predicted membrane protein [Function unknown]; Region: COG2364
866895007114	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
866895007115	recombination factor protein RarA; Reviewed; Region: PRK13342
866895007116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895007117	Walker A motif; other site
866895007118	ATP binding site [chemical binding]; other site
866895007119	Walker B motif; other site
866895007120	arginine finger; other site
866895007121	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
866895007122	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
866895007123	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
866895007124	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
866895007125	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
866895007126	dimer interface [polypeptide binding]; other site
866895007127	anticodon binding site; other site
866895007128	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
866895007129	homodimer interface [polypeptide binding]; other site
866895007130	motif 1; other site
866895007131	active site
866895007132	motif 2; other site
866895007133	GAD domain; Region: GAD; pfam02938
866895007134	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
866895007135	motif 3; other site
866895007136	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
866895007137	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
866895007138	dimer interface [polypeptide binding]; other site
866895007139	motif 1; other site
866895007140	active site
866895007141	motif 2; other site
866895007142	motif 3; other site
866895007143	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
866895007144	anticodon binding site; other site
866895007145	Bacterial SH3 domain homologues; Region: SH3b; smart00287
866895007146	Bacterial SH3 domain; Region: SH3_3; pfam08239
866895007147	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
866895007148	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
866895007149	active site
866895007150	metal binding site [ion binding]; metal-binding site
866895007151	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
866895007152	putative active site [active]
866895007153	dimerization interface [polypeptide binding]; other site
866895007154	putative tRNAtyr binding site [nucleotide binding]; other site
866895007155	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
866895007156	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866895007157	Zn2+ binding site [ion binding]; other site
866895007158	Mg2+ binding site [ion binding]; other site
866895007159	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
866895007160	synthetase active site [active]
866895007161	NTP binding site [chemical binding]; other site
866895007162	metal binding site [ion binding]; metal-binding site
866895007163	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
866895007164	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
866895007165	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895007166	active site
866895007167	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
866895007168	DHH family; Region: DHH; pfam01368
866895007169	DHHA1 domain; Region: DHHA1; pfam02272
866895007170	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
866895007171	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
866895007172	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
866895007173	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
866895007174	Protein export membrane protein; Region: SecD_SecF; pfam02355
866895007175	stage V sporulation protein B; Region: spore_V_B; TIGR02900
866895007176	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
866895007177	Predicted membrane protein [Function unknown]; Region: COG2323
866895007178	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
866895007179	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
866895007180	transmembrane helices; other site
866895007181	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
866895007182	Preprotein translocase subunit; Region: YajC; pfam02699
866895007183	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
866895007184	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
866895007185	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
866895007186	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
866895007187	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
866895007188	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
866895007189	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895007190	Walker A motif; other site
866895007191	ATP binding site [chemical binding]; other site
866895007192	Walker B motif; other site
866895007193	arginine finger; other site
866895007194	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
866895007195	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
866895007196	RuvA N terminal domain; Region: RuvA_N; pfam01330
866895007197	Amidase; Region: Amidase; cl11426
866895007198	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
866895007199	Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977
866895007200	BofC C-terminal domain; Region: BofC_C; pfam08955
866895007201	hypothetical protein; Validated; Region: PRK00110
866895007202	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
866895007203	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
866895007204	homodimer interface [polypeptide binding]; other site
866895007205	NAD binding pocket [chemical binding]; other site
866895007206	ATP binding pocket [chemical binding]; other site
866895007207	Mg binding site [ion binding]; other site
866895007208	active-site loop [active]
866895007209	Phosphotransferase enzyme family; Region: APH; pfam01636
866895007210	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
866895007211	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895007212	prephenate dehydratase; Provisional; Region: PRK11898
866895007213	Prephenate dehydratase; Region: PDT; pfam00800
866895007214	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
866895007215	putative L-Phe binding site [chemical binding]; other site
866895007216	hypothetical protein; Provisional; Region: PRK04435
866895007217	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
866895007218	GTPase CgtA; Reviewed; Region: obgE; PRK12297
866895007219	GTP1/OBG; Region: GTP1_OBG; pfam01018
866895007220	Obg GTPase; Region: Obg; cd01898
866895007221	G1 box; other site
866895007222	GTP/Mg2+ binding site [chemical binding]; other site
866895007223	Switch I region; other site
866895007224	G2 box; other site
866895007225	G3 box; other site
866895007226	Switch II region; other site
866895007227	G4 box; other site
866895007228	G5 box; other site
866895007229	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
866895007230	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
866895007231	Protein of unknown function (DUF464); Region: DUF464; pfam04327
866895007232	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
866895007233	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
866895007234	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
866895007235	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
866895007236	homodimer interface [polypeptide binding]; other site
866895007237	oligonucleotide binding site [chemical binding]; other site
866895007238	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
866895007239	Peptidase family M50; Region: Peptidase_M50; pfam02163
866895007240	active site
866895007241	putative substrate binding region [chemical binding]; other site
866895007242	Peptidase family M23; Region: Peptidase_M23; pfam01551
866895007243	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
866895007244	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
866895007245	Switch I; other site
866895007246	Switch II; other site
866895007247	septum formation inhibitor; Reviewed; Region: minC; PRK00513
866895007248	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
866895007249	rod shape-determining protein MreD; Region: MreD; cl01087
866895007250	rod shape-determining protein MreC; Provisional; Region: PRK13922
866895007251	rod shape-determining protein MreC; Region: MreC; pfam04085
866895007252	rod shape-determining protein MreB; Provisional; Region: PRK13927
866895007253	MreB and similar proteins; Region: MreB_like; cd10225
866895007254	nucleotide binding site [chemical binding]; other site
866895007255	Mg binding site [ion binding]; other site
866895007256	putative protofilament interaction site [polypeptide binding]; other site
866895007257	RodZ interaction site [polypeptide binding]; other site
866895007258	hypothetical protein; Reviewed; Region: PRK00024
866895007259	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
866895007260	helix-hairpin-helix signature motif; other site
866895007261	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
866895007262	MPN+ (JAMM) motif; other site
866895007263	Zinc-binding site [ion binding]; other site
866895007264	Maf-like protein; Region: Maf; pfam02545
866895007265	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
866895007266	active site
866895007267	dimer interface [polypeptide binding]; other site
866895007268	Sporulation related domain; Region: SPOR; cl10051
866895007269	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
866895007270	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
866895007271	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
866895007272	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
866895007273	GAF domain; Region: GAF_3; pfam13492
866895007274	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866895007275	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866895007276	metal binding site [ion binding]; metal-binding site
866895007277	active site
866895007278	I-site; other site
866895007279	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
866895007280	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895007281	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866895007282	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
866895007283	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866895007284	active site
866895007285	HIGH motif; other site
866895007286	nucleotide binding site [chemical binding]; other site
866895007287	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
866895007288	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
866895007289	active site
866895007290	KMSKS motif; other site
866895007291	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
866895007292	tRNA binding surface [nucleotide binding]; other site
866895007293	anticodon binding site; other site
866895007294	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
866895007295	stage VI sporulation protein D; Region: spore_VI_D; TIGR02907
866895007296	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895007297	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
866895007298	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895007299	inhibitor-cofactor binding pocket; inhibition site
866895007300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895007301	catalytic residue [active]
866895007302	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
866895007303	dimer interface [polypeptide binding]; other site
866895007304	active site
866895007305	Schiff base residues; other site
866895007306	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
866895007307	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
866895007308	active site
866895007309	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
866895007310	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
866895007311	domain interfaces; other site
866895007312	active site
866895007313	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
866895007314	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
866895007315	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
866895007316	tRNA; other site
866895007317	putative tRNA binding site [nucleotide binding]; other site
866895007318	putative NADP binding site [chemical binding]; other site
866895007319	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
866895007320	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866895007321	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866895007322	Walker A/P-loop; other site
866895007323	ATP binding site [chemical binding]; other site
866895007324	Q-loop/lid; other site
866895007325	ABC transporter signature motif; other site
866895007326	Walker B; other site
866895007327	D-loop; other site
866895007328	H-loop/switch region; other site
866895007329	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866895007330	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866895007331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895007332	dimer interface [polypeptide binding]; other site
866895007333	conserved gate region; other site
866895007334	putative PBP binding loops; other site
866895007335	ABC-ATPase subunit interface; other site
866895007336	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866895007337	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866895007338	substrate binding pocket [chemical binding]; other site
866895007339	membrane-bound complex binding site; other site
866895007340	hinge residues; other site
866895007341	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
866895007342	G1 box; other site
866895007343	GTP/Mg2+ binding site [chemical binding]; other site
866895007344	Switch I region; other site
866895007345	G2 box; other site
866895007346	G3 box; other site
866895007347	Switch II region; other site
866895007348	G4 box; other site
866895007349	G5 box; other site
866895007350	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
866895007351	Found in ATP-dependent protease La (LON); Region: LON; smart00464
866895007352	Found in ATP-dependent protease La (LON); Region: LON; smart00464
866895007353	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895007354	Walker A motif; other site
866895007355	ATP binding site [chemical binding]; other site
866895007356	Walker B motif; other site
866895007357	arginine finger; other site
866895007358	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
866895007359	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
866895007360	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
866895007361	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895007362	Walker A motif; other site
866895007363	ATP binding site [chemical binding]; other site
866895007364	Walker B motif; other site
866895007365	arginine finger; other site
866895007366	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
866895007367	trigger factor; Provisional; Region: tig; PRK01490
866895007368	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866895007369	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
866895007370	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
866895007371	binding surface
866895007372	Tetratricopeptide repeat; Region: TPR_16; pfam13432
866895007373	TPR motif; other site
866895007374	Transposase; Region: HTH_Tnp_1; cl17663
866895007375	putative transposase OrfB; Reviewed; Region: PHA02517
866895007376	HTH-like domain; Region: HTH_21; pfam13276
866895007377	Integrase core domain; Region: rve; pfam00665
866895007378	Integrase core domain; Region: rve_3; pfam13683
866895007379	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
866895007380	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
866895007381	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
866895007382	Subunit I/III interface [polypeptide binding]; other site
866895007383	Subunit III/IV interface [polypeptide binding]; other site
866895007384	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
866895007385	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
866895007386	D-pathway; other site
866895007387	Putative ubiquinol binding site [chemical binding]; other site
866895007388	Low-spin heme (heme b) binding site [chemical binding]; other site
866895007389	Putative water exit pathway; other site
866895007390	Binuclear center (heme o3/CuB) [ion binding]; other site
866895007391	K-pathway; other site
866895007392	Putative proton exit pathway; other site
866895007393	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
866895007394	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
866895007395	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
866895007396	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
866895007397	PA/protease or protease-like domain interface [polypeptide binding]; other site
866895007398	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
866895007399	Peptidase family M28; Region: Peptidase_M28; pfam04389
866895007400	metal binding site [ion binding]; metal-binding site
866895007401	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
866895007402	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866895007403	active site
866895007404	metal binding site [ion binding]; metal-binding site
866895007405	homotetramer interface [polypeptide binding]; other site
866895007406	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
866895007407	active site
866895007408	dimerization interface [polypeptide binding]; other site
866895007409	ribonuclease PH; Reviewed; Region: rph; PRK00173
866895007410	Ribonuclease PH; Region: RNase_PH_bact; cd11362
866895007411	hexamer interface [polypeptide binding]; other site
866895007412	active site
866895007413	Sporulation and spore germination; Region: Germane; pfam10646
866895007414	Spore germination protein [General function prediction only]; Region: COG5401
866895007415	Sporulation and spore germination; Region: Germane; pfam10646
866895007416	glutamate racemase; Provisional; Region: PRK00865
866895007417	Transcriptional regulators [Transcription]; Region: MarR; COG1846
866895007418	MarR family; Region: MarR; pfam01047
866895007419	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895007420	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895007421	DNA binding residues [nucleotide binding]
866895007422	dimerization interface [polypeptide binding]; other site
866895007423	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895007424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895007425	active site
866895007426	phosphorylation site [posttranslational modification]
866895007427	intermolecular recognition site; other site
866895007428	dimerization interface [polypeptide binding]; other site
866895007429	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895007430	DNA binding residues [nucleotide binding]
866895007431	dimerization interface [polypeptide binding]; other site
866895007432	potential frameshift: common BLAST hit: gi|325289008|ref|YP_004265189.1| signal transduction histidine kinase
866895007433	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866895007434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895007435	ATP binding site [chemical binding]; other site
866895007436	Mg2+ binding site [ion binding]; other site
866895007437	G-X-G motif; other site
866895007438	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
866895007439	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
866895007440	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866895007441	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
866895007442	L-aspartate oxidase; Provisional; Region: PRK06175
866895007443	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
866895007444	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
866895007445	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
866895007446	putative Iron-sulfur protein interface [polypeptide binding]; other site
866895007447	proximal heme binding site [chemical binding]; other site
866895007448	distal heme binding site [chemical binding]; other site
866895007449	putative dimer interface [polypeptide binding]; other site
866895007450	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
866895007451	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
866895007452	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
866895007453	GIY-YIG motif/motif A; other site
866895007454	active site
866895007455	catalytic site [active]
866895007456	putative DNA binding site [nucleotide binding]; other site
866895007457	metal binding site [ion binding]; metal-binding site
866895007458	UvrB/uvrC motif; Region: UVR; pfam02151
866895007459	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
866895007460	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866895007461	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866895007462	catalytic residues [active]
866895007463	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
866895007464	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
866895007465	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
866895007466	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
866895007467	Ligand binding site [chemical binding]; other site
866895007468	Electron transfer flavoprotein domain; Region: ETF; pfam01012
866895007469	enoyl-CoA hydratase; Provisional; Region: PRK07658
866895007470	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866895007471	substrate binding site [chemical binding]; other site
866895007472	oxyanion hole (OAH) forming residues; other site
866895007473	trimer interface [polypeptide binding]; other site
866895007474	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
866895007475	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895007476	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895007477	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
866895007478	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
866895007479	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
866895007480	acyl-activating enzyme (AAE) consensus motif; other site
866895007481	putative AMP binding site [chemical binding]; other site
866895007482	putative active site [active]
866895007483	putative CoA binding site [chemical binding]; other site
866895007484	Predicted membrane protein [Function unknown]; Region: COG3766
866895007485	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
866895007486	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
866895007487	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
866895007488	MutS domain III; Region: MutS_III; pfam05192
866895007489	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
866895007490	Walker A/P-loop; other site
866895007491	ATP binding site [chemical binding]; other site
866895007492	Q-loop/lid; other site
866895007493	ABC transporter signature motif; other site
866895007494	Walker B; other site
866895007495	D-loop; other site
866895007496	H-loop/switch region; other site
866895007497	Smr domain; Region: Smr; pfam01713
866895007498	hypothetical protein; Provisional; Region: PRK08609
866895007499	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
866895007500	active site
866895007501	primer binding site [nucleotide binding]; other site
866895007502	NTP  binding site [chemical binding]; other site
866895007503	metal binding triad [ion binding]; metal-binding site
866895007504	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
866895007505	active site
866895007506	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
866895007507	Colicin V production protein; Region: Colicin_V; pfam02674
866895007508	Cell division protein ZapA; Region: ZapA; cl01146
866895007509	ribonuclease HIII; Provisional; Region: PRK00996
866895007510	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
866895007511	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
866895007512	RNA/DNA hybrid binding site [nucleotide binding]; other site
866895007513	active site
866895007514	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
866895007515	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
866895007516	putative tRNA-binding site [nucleotide binding]; other site
866895007517	B3/4 domain; Region: B3_4; pfam03483
866895007518	tRNA synthetase B5 domain; Region: B5; smart00874
866895007519	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
866895007520	dimer interface [polypeptide binding]; other site
866895007521	motif 1; other site
866895007522	motif 3; other site
866895007523	motif 2; other site
866895007524	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
866895007525	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
866895007526	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
866895007527	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
866895007528	dimer interface [polypeptide binding]; other site
866895007529	motif 1; other site
866895007530	active site
866895007531	motif 2; other site
866895007532	motif 3; other site
866895007533	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
866895007534	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
866895007535	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866895007536	small acid-soluble spore protein SspI; Provisional; Region: PRK02955
866895007537	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
866895007538	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
866895007539	oligomer interface [polypeptide binding]; other site
866895007540	active site
866895007541	metal binding site [ion binding]; metal-binding site
866895007542	dUTPase; Region: dUTPase_2; pfam08761
866895007543	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
866895007544	active site
866895007545	homodimer interface [polypeptide binding]; other site
866895007546	metal binding site [ion binding]; metal-binding site
866895007547	Uncharacterized conserved protein [Function unknown]; Region: COG0398
866895007548	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
866895007549	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
866895007550	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
866895007551	23S rRNA binding site [nucleotide binding]; other site
866895007552	L21 binding site [polypeptide binding]; other site
866895007553	L13 binding site [polypeptide binding]; other site
866895007554	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
866895007555	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
866895007556	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
866895007557	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
866895007558	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
866895007559	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
866895007560	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
866895007561	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
866895007562	active site
866895007563	dimer interface [polypeptide binding]; other site
866895007564	motif 1; other site
866895007565	motif 2; other site
866895007566	motif 3; other site
866895007567	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
866895007568	anticodon binding site; other site
866895007569	YtxC-like family; Region: YtxC; cl08500
866895007570	primosomal protein DnaI; Reviewed; Region: PRK08939
866895007571	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
866895007572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895007573	Walker A motif; other site
866895007574	ATP binding site [chemical binding]; other site
866895007575	Walker B motif; other site
866895007576	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
866895007577	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
866895007578	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
866895007579	ATP cone domain; Region: ATP-cone; pfam03477
866895007580	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
866895007581	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
866895007582	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
866895007583	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
866895007584	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
866895007585	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
866895007586	CoA-binding site [chemical binding]; other site
866895007587	ATP-binding [chemical binding]; other site
866895007588	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
866895007589	Domain of unknown function DUF; Region: DUF204; pfam02659
866895007590	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
866895007591	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
866895007592	DNA binding site [nucleotide binding]
866895007593	catalytic residue [active]
866895007594	H2TH interface [polypeptide binding]; other site
866895007595	putative catalytic residues [active]
866895007596	turnover-facilitating residue; other site
866895007597	intercalation triad [nucleotide binding]; other site
866895007598	8OG recognition residue [nucleotide binding]; other site
866895007599	putative reading head residues; other site
866895007600	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
866895007601	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
866895007602	DNA polymerase I; Provisional; Region: PRK05755
866895007603	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
866895007604	active site
866895007605	metal binding site 1 [ion binding]; metal-binding site
866895007606	putative 5' ssDNA interaction site; other site
866895007607	metal binding site 3; metal-binding site
866895007608	metal binding site 2 [ion binding]; metal-binding site
866895007609	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
866895007610	putative DNA binding site [nucleotide binding]; other site
866895007611	putative metal binding site [ion binding]; other site
866895007612	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
866895007613	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
866895007614	active site
866895007615	DNA binding site [nucleotide binding]
866895007616	catalytic site [active]
866895007617	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866895007618	dimerization interface [polypeptide binding]; other site
866895007619	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
866895007620	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895007621	putative active site [active]
866895007622	heme pocket [chemical binding]; other site
866895007623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866895007624	dimer interface [polypeptide binding]; other site
866895007625	phosphorylation site [posttranslational modification]
866895007626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895007627	ATP binding site [chemical binding]; other site
866895007628	Mg2+ binding site [ion binding]; other site
866895007629	G-X-G motif; other site
866895007630	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866895007631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895007632	active site
866895007633	phosphorylation site [posttranslational modification]
866895007634	intermolecular recognition site; other site
866895007635	dimerization interface [polypeptide binding]; other site
866895007636	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866895007637	DNA binding site [nucleotide binding]
866895007638	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
866895007639	dimer interaction site [polypeptide binding]; other site
866895007640	substrate-binding tunnel; other site
866895007641	active site
866895007642	catalytic site [active]
866895007643	substrate binding site [chemical binding]; other site
866895007644	malate dehydrogenase; Reviewed; Region: PRK06223
866895007645	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
866895007646	NAD(P) binding site [chemical binding]; other site
866895007647	dimer interface [polypeptide binding]; other site
866895007648	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866895007649	substrate binding site [chemical binding]; other site
866895007650	isocitrate dehydrogenase; Reviewed; Region: PRK07006
866895007651	isocitrate dehydrogenase; Validated; Region: PRK07362
866895007652	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
866895007653	dimer interface [polypeptide binding]; other site
866895007654	Citrate synthase; Region: Citrate_synt; pfam00285
866895007655	active site
866895007656	citrylCoA binding site [chemical binding]; other site
866895007657	oxalacetate/citrate binding site [chemical binding]; other site
866895007658	coenzyme A binding site [chemical binding]; other site
866895007659	catalytic triad [active]
866895007660	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
866895007661	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866895007662	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
866895007663	pyruvate kinase; Provisional; Region: PRK06354
866895007664	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
866895007665	domain interfaces; other site
866895007666	active site
866895007667	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
866895007668	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
866895007669	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
866895007670	active site
866895007671	ADP/pyrophosphate binding site [chemical binding]; other site
866895007672	dimerization interface [polypeptide binding]; other site
866895007673	allosteric effector site; other site
866895007674	fructose-1,6-bisphosphate binding site; other site
866895007675	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
866895007676	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
866895007677	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
866895007678	TIGR02300 family protein; Region: FYDLN_acid
866895007679	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
866895007680	Transcriptional regulators [Transcription]; Region: FadR; COG2186
866895007681	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895007682	DNA-binding site [nucleotide binding]; DNA binding site
866895007683	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
866895007684	Malic enzyme, N-terminal domain; Region: malic; pfam00390
866895007685	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
866895007686	putative NAD(P) binding site [chemical binding]; other site
866895007687	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920
866895007688	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
866895007689	active site
866895007690	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
866895007691	generic binding surface II; other site
866895007692	generic binding surface I; other site
866895007693	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
866895007694	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
866895007695	DHH family; Region: DHH; pfam01368
866895007696	DHHA1 domain; Region: DHHA1; pfam02272
866895007697	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
866895007698	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895007699	DNA-binding site [nucleotide binding]; DNA binding site
866895007700	DRTGG domain; Region: DRTGG; pfam07085
866895007701	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
866895007702	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
866895007703	active site 2 [active]
866895007704	active site 1 [active]
866895007705	metal-dependent hydrolase; Provisional; Region: PRK00685
866895007706	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
866895007707	spermidine synthase; Provisional; Region: PRK03612
866895007708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895007709	S-adenosylmethionine binding site [chemical binding]; other site
866895007710	Predicted membrane protein [Function unknown]; Region: COG3766
866895007711	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
866895007712	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
866895007713	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
866895007714	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
866895007715	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
866895007716	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
866895007717	Sodium Bile acid symporter family; Region: SBF; pfam01758
866895007718	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
866895007719	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
866895007720	hexamer interface [polypeptide binding]; other site
866895007721	ligand binding site [chemical binding]; other site
866895007722	putative active site [active]
866895007723	NAD(P) binding site [chemical binding]; other site
866895007724	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
866895007725	classical (c) SDRs; Region: SDR_c; cd05233
866895007726	NAD(P) binding site [chemical binding]; other site
866895007727	active site
866895007728	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
866895007729	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
866895007730	Na binding site [ion binding]; other site
866895007731	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866895007732	Ligand Binding Site [chemical binding]; other site
866895007733	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
866895007734	MPT binding site; other site
866895007735	trimer interface [polypeptide binding]; other site
866895007736	EcsC protein family; Region: EcsC; pfam12787
866895007737	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
866895007738	propionate/acetate kinase; Provisional; Region: PRK12379
866895007739	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
866895007740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895007741	S-adenosylmethionine binding site [chemical binding]; other site
866895007742	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
866895007743	ATP-NAD kinase; Region: NAD_kinase; pfam01513
866895007744	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
866895007745	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
866895007746	active site
866895007747	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
866895007748	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
866895007749	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
866895007750	Ligand Binding Site [chemical binding]; other site
866895007751	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
866895007752	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
866895007753	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866895007754	catalytic residue [active]
866895007755	septation ring formation regulator EzrA; Provisional; Region: PRK04778
866895007756	histidinol-phosphatase; Reviewed; Region: PRK08123
866895007757	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
866895007758	active site
866895007759	dimer interface [polypeptide binding]; other site
866895007760	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895007761	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895007762	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
866895007763	GAF domain; Region: GAF_2; pfam13185
866895007764	GAF domain; Region: GAF; cl17456
866895007765	GAF domain; Region: GAF_2; pfam13185
866895007766	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866895007767	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866895007768	metal binding site [ion binding]; metal-binding site
866895007769	active site
866895007770	I-site; other site
866895007771	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
866895007772	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
866895007773	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866895007774	RNA binding surface [nucleotide binding]; other site
866895007775	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
866895007776	active site
866895007777	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
866895007778	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
866895007779	active site
866895007780	HIGH motif; other site
866895007781	dimer interface [polypeptide binding]; other site
866895007782	KMSKS motif; other site
866895007783	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866895007784	RNA binding surface [nucleotide binding]; other site
866895007785	Transglycosylase; Region: Transgly; pfam00912
866895007786	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
866895007787	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
866895007788	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895007789	Coenzyme A binding pocket [chemical binding]; other site
866895007790	FOG: CBS domain [General function prediction only]; Region: COG0517
866895007791	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
866895007792	C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883
866895007793	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
866895007794	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
866895007795	active site
866895007796	Zn binding site [ion binding]; other site
866895007797	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
866895007798	flagellar motor protein MotS; Reviewed; Region: PRK06925
866895007799	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
866895007800	ligand binding site [chemical binding]; other site
866895007801	flagellar motor protein MotP; Reviewed; Region: PRK06926
866895007802	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
866895007803	catabolite control protein A; Region: ccpA; TIGR01481
866895007804	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895007805	DNA binding site [nucleotide binding]
866895007806	domain linker motif; other site
866895007807	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
866895007808	dimerization interface [polypeptide binding]; other site
866895007809	effector binding site; other site
866895007810	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
866895007811	Chorismate mutase type II; Region: CM_2; cl00693
866895007812	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
866895007813	Protein of unknown function (DUF2847); Region: DUF2847; cl17683
866895007814	YtxH-like protein; Region: YtxH; pfam12732
866895007815	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
866895007816	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
866895007817	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866895007818	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895007819	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866895007820	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
866895007821	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
866895007822	active site
866895007823	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
866895007824	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
866895007825	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
866895007826	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
866895007827	putative tRNA-binding site [nucleotide binding]; other site
866895007828	hypothetical protein; Provisional; Region: PRK13668
866895007829	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866895007830	catalytic residues [active]
866895007831	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
866895007832	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
866895007833	YtoQ family protein; Region: YtoQ_fam; TIGR03646
866895007834	NTPase; Reviewed; Region: PRK03114
866895007835	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
866895007836	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
866895007837	oligomer interface [polypeptide binding]; other site
866895007838	active site
866895007839	metal binding site [ion binding]; metal-binding site
866895007840	Predicted small secreted protein [Function unknown]; Region: COG5584
866895007841	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
866895007842	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
866895007843	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895007844	S-adenosylmethionine binding site [chemical binding]; other site
866895007845	Phosphotransferase enzyme family; Region: APH; pfam01636
866895007846	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
866895007847	active site
866895007848	substrate binding site [chemical binding]; other site
866895007849	ATP binding site [chemical binding]; other site
866895007850	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
866895007851	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
866895007852	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
866895007853	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866895007854	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
866895007855	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
866895007856	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
866895007857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895007858	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895007859	putative substrate translocation pore; other site
866895007860	dipeptidase PepV; Reviewed; Region: PRK07318
866895007861	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
866895007862	active site
866895007863	metal binding site [ion binding]; metal-binding site
866895007864	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
866895007865	TrkA-N domain; Region: TrkA_N; pfam02254
866895007866	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
866895007867	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866895007868	RNA binding surface [nucleotide binding]; other site
866895007869	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
866895007870	active site
866895007871	uracil binding [chemical binding]; other site
866895007872	stage V sporulation protein B; Region: spore_V_B; TIGR02900
866895007873	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
866895007874	HI0933-like protein; Region: HI0933_like; pfam03486
866895007875	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895007876	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
866895007877	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866895007878	active site residue [active]
866895007879	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
866895007880	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
866895007881	HIGH motif; other site
866895007882	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
866895007883	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866895007884	active site
866895007885	KMSKS motif; other site
866895007886	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
866895007887	tRNA binding surface [nucleotide binding]; other site
866895007888	Methyltransferase domain; Region: Methyltransf_31; pfam13847
866895007889	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
866895007890	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
866895007891	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866895007892	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866895007893	PGAP1-like protein; Region: PGAP1; pfam07819
866895007894	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
866895007895	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
866895007896	trimer interface [polypeptide binding]; other site
866895007897	putative metal binding site [ion binding]; other site
866895007898	S-adenosylmethionine synthetase; Validated; Region: PRK05250
866895007899	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
866895007900	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
866895007901	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
866895007902	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
866895007903	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
866895007904	active site
866895007905	substrate-binding site [chemical binding]; other site
866895007906	metal-binding site [ion binding]
866895007907	ATP binding site [chemical binding]; other site
866895007908	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
866895007909	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
866895007910	nudix motif; other site
866895007911	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
866895007912	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
866895007913	active site
866895007914	octamer interface [polypeptide binding]; other site
866895007915	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
866895007916	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
866895007917	acyl-activating enzyme (AAE) consensus motif; other site
866895007918	putative AMP binding site [chemical binding]; other site
866895007919	putative active site [active]
866895007920	putative CoA binding site [chemical binding]; other site
866895007921	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866895007922	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
866895007923	substrate binding site [chemical binding]; other site
866895007924	oxyanion hole (OAH) forming residues; other site
866895007925	trimer interface [polypeptide binding]; other site
866895007926	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
866895007927	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
866895007928	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
866895007929	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
866895007930	dimer interface [polypeptide binding]; other site
866895007931	tetramer interface [polypeptide binding]; other site
866895007932	PYR/PP interface [polypeptide binding]; other site
866895007933	TPP binding site [chemical binding]; other site
866895007934	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
866895007935	TPP-binding site; other site
866895007936	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
866895007937	isochorismate synthases; Region: isochor_syn; TIGR00543
866895007938	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
866895007939	UbiA prenyltransferase family; Region: UbiA; pfam01040
866895007940	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
866895007941	CoenzymeA binding site [chemical binding]; other site
866895007942	subunit interaction site [polypeptide binding]; other site
866895007943	PHB binding site; other site
866895007944	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
866895007945	Predicted membrane protein [Function unknown]; Region: COG3601
866895007946	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
866895007947	YolD-like protein; Region: YolD; pfam08863
866895007948	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
866895007949	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
866895007950	active site
866895007951	metal binding site [ion binding]; metal-binding site
866895007952	S-layer homology domain; Region: SLH; pfam00395
866895007953	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
866895007954	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
866895007955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895007956	Coenzyme A binding pocket [chemical binding]; other site
866895007957	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
866895007958	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
866895007959	oligomer interface [polypeptide binding]; other site
866895007960	active site
866895007961	metal binding site [ion binding]; metal-binding site
866895007962	Ion channel; Region: Ion_trans_2; pfam07885
866895007963	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
866895007964	TrkA-N domain; Region: TrkA_N; pfam02254
866895007965	YugN-like family; Region: YugN; pfam08868
866895007966	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
866895007967	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
866895007968	active site
866895007969	dimer interface [polypeptide binding]; other site
866895007970	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
866895007971	dimer interface [polypeptide binding]; other site
866895007972	active site
866895007973	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
866895007974	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
866895007975	dimer interface [polypeptide binding]; other site
866895007976	active site
866895007977	metal binding site [ion binding]; metal-binding site
866895007978	Uncharacterized conserved protein [Function unknown]; Region: COG2155
866895007979	general stress protein 13; Validated; Region: PRK08059
866895007980	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
866895007981	RNA binding site [nucleotide binding]; other site
866895007982	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895007983	non-specific DNA binding site [nucleotide binding]; other site
866895007984	salt bridge; other site
866895007985	sequence-specific DNA binding site [nucleotide binding]; other site
866895007986	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
866895007987	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866895007988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895007989	homodimer interface [polypeptide binding]; other site
866895007990	catalytic residue [active]
866895007991	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
866895007992	E-class dimer interface [polypeptide binding]; other site
866895007993	P-class dimer interface [polypeptide binding]; other site
866895007994	active site
866895007995	Cu2+ binding site [ion binding]; other site
866895007996	Zn2+ binding site [ion binding]; other site
866895007997	Kinase associated protein B; Region: KapB; pfam08810
866895007998	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
866895007999	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
866895008000	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
866895008001	TrkA-C domain; Region: TrkA_C; pfam02080
866895008002	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
866895008003	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
866895008004	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866895008005	Divergent PAP2 family; Region: DUF212; pfam02681
866895008006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
866895008007	Putative membrane protein; Region: YuiB; pfam14068
866895008008	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
866895008009	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895008010	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
866895008011	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895008012	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895008013	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
866895008014	hypothetical protein; Provisional; Region: PRK13669
866895008015	Protein of unknown function (DUF1462); Region: DUF1462; pfam07315
866895008016	NifU-like domain; Region: NifU; cl00484
866895008017	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
866895008018	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
866895008019	dimerization interface [polypeptide binding]; other site
866895008020	ligand binding site [chemical binding]; other site
866895008021	NADP binding site [chemical binding]; other site
866895008022	catalytic site [active]
866895008023	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
866895008024	tetramer interfaces [polypeptide binding]; other site
866895008025	binuclear metal-binding site [ion binding]; other site
866895008026	Acyltransferase family; Region: Acyl_transf_3; pfam01757
866895008027	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
866895008028	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895008029	active site
866895008030	motif I; other site
866895008031	motif II; other site
866895008032	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895008033	Uncharacterized conserved protein [Function unknown]; Region: COG2445
866895008034	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
866895008035	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
866895008036	putative active site [active]
866895008037	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
866895008038	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
866895008039	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
866895008040	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
866895008041	Peptidase family M23; Region: Peptidase_M23; pfam01551
866895008042	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
866895008043	Na2 binding site [ion binding]; other site
866895008044	putative substrate binding site 1 [chemical binding]; other site
866895008045	Na binding site 1 [ion binding]; other site
866895008046	putative substrate binding site 2 [chemical binding]; other site
866895008047	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
866895008048	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
866895008049	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
866895008050	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
866895008051	active site
866895008052	metal binding site [ion binding]; metal-binding site
866895008053	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
866895008054	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
866895008055	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
866895008056	FeS assembly protein SufB; Region: sufB; TIGR01980
866895008057	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
866895008058	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
866895008059	trimerization site [polypeptide binding]; other site
866895008060	active site
866895008061	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
866895008062	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
866895008063	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866895008064	catalytic residue [active]
866895008065	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
866895008066	FeS assembly protein SufD; Region: sufD; TIGR01981
866895008067	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
866895008068	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
866895008069	Walker A/P-loop; other site
866895008070	ATP binding site [chemical binding]; other site
866895008071	Q-loop/lid; other site
866895008072	ABC transporter signature motif; other site
866895008073	Walker B; other site
866895008074	D-loop; other site
866895008075	H-loop/switch region; other site
866895008076	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
866895008077	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
866895008078	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
866895008079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895008080	ABC-ATPase subunit interface; other site
866895008081	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
866895008082	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
866895008083	Walker A/P-loop; other site
866895008084	ATP binding site [chemical binding]; other site
866895008085	Q-loop/lid; other site
866895008086	ABC transporter signature motif; other site
866895008087	Walker B; other site
866895008088	D-loop; other site
866895008089	H-loop/switch region; other site
866895008090	NIL domain; Region: NIL; pfam09383
866895008091	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
866895008092	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866895008093	catalytic residues [active]
866895008094	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866895008095	catalytic residues [active]
866895008096	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
866895008097	active site
866895008098	metal binding site [ion binding]; metal-binding site
866895008099	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
866895008100	lipoyl attachment site [posttranslational modification]; other site
866895008101	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
866895008102	ArsC family; Region: ArsC; pfam03960
866895008103	putative ArsC-like catalytic residues; other site
866895008104	putative TRX-like catalytic residues [active]
866895008105	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866895008106	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895008107	active site
866895008108	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
866895008109	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866895008110	dimer interface [polypeptide binding]; other site
866895008111	active site
866895008112	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
866895008113	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
866895008114	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
866895008115	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
866895008116	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
866895008117	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866895008118	substrate binding site [chemical binding]; other site
866895008119	oxyanion hole (OAH) forming residues; other site
866895008120	Proline dehydrogenase; Region: Pro_dh; cl03282
866895008121	Coat F domain; Region: Coat_F; pfam07875
866895008122	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
866895008123	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866895008124	metal-binding site [ion binding]
866895008125	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
866895008126	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895008127	B12 binding domain; Region: B12-binding_2; pfam02607
866895008128	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
866895008129	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
866895008130	B12 binding site [chemical binding]; other site
866895008131	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
866895008132	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
866895008133	Protein of unknown function DUF58; Region: DUF58; pfam01882
866895008134	MoxR-like ATPases [General function prediction only]; Region: COG0714
866895008135	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895008136	Walker A motif; other site
866895008137	ATP binding site [chemical binding]; other site
866895008138	Walker B motif; other site
866895008139	arginine finger; other site
866895008140	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
866895008141	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
866895008142	YfhD-like protein; Region: YfhD; pfam14151
866895008143	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
866895008144	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895008145	putative substrate translocation pore; other site
866895008146	Predicted transcriptional regulators [Transcription]; Region: COG1378
866895008147	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
866895008148	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
866895008149	C-terminal domain interface [polypeptide binding]; other site
866895008150	sugar binding site [chemical binding]; other site
866895008151	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866895008152	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
866895008153	active site
866895008154	ATP binding site [chemical binding]; other site
866895008155	substrate binding site [chemical binding]; other site
866895008156	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
866895008157	Protein of unknown function (DUF4025); Region: DUF4025; pfam13217
866895008158	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309
866895008159	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
866895008160	isocitrate lyase; Provisional; Region: PRK15063
866895008161	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
866895008162	tetramer interface [polypeptide binding]; other site
866895008163	active site
866895008164	Mg2+/Mn2+ binding site [ion binding]; other site
866895008165	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
866895008166	malate synthase A; Region: malate_syn_A; TIGR01344
866895008167	active site
866895008168	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895008169	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895008170	active site
866895008171	catalytic tetrad [active]
866895008172	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
866895008173	dimer interface [polypeptide binding]; other site
866895008174	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895008175	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866895008176	catalytic core [active]
866895008177	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
866895008178	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
866895008179	FAD binding domain; Region: FAD_binding_4; pfam01565
866895008180	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
866895008181	short chain dehydrogenase; Provisional; Region: PRK07454
866895008182	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
866895008183	NADP binding site [chemical binding]; other site
866895008184	substrate binding site [chemical binding]; other site
866895008185	active site
866895008186	YpjP-like protein; Region: YpjP; pfam14005
866895008187	Coat F domain; Region: Coat_F; pfam07875
866895008188	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
866895008189	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
866895008190	Amidinotransferase; Region: Amidinotransf; cl12043
866895008191	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
866895008192	active pocket/dimerization site; other site
866895008193	active site
866895008194	phosphorylation site [posttranslational modification]
866895008195	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
866895008196	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
866895008197	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
866895008198	glycerol kinase; Provisional; Region: glpK; PRK00047
866895008199	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
866895008200	N- and C-terminal domain interface [polypeptide binding]; other site
866895008201	active site
866895008202	MgATP binding site [chemical binding]; other site
866895008203	catalytic site [active]
866895008204	metal binding site [ion binding]; metal-binding site
866895008205	glycerol binding site [chemical binding]; other site
866895008206	homotetramer interface [polypeptide binding]; other site
866895008207	homodimer interface [polypeptide binding]; other site
866895008208	FBP binding site [chemical binding]; other site
866895008209	protein IIAGlc interface [polypeptide binding]; other site
866895008210	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
866895008211	amphipathic channel; other site
866895008212	Asn-Pro-Ala signature motifs; other site
866895008213	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
866895008214	SmpB-tmRNA interface; other site
866895008215	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895008216	ribonuclease R; Region: RNase_R; TIGR02063
866895008217	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
866895008218	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
866895008219	RNB domain; Region: RNB; pfam00773
866895008220	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
866895008221	RNA binding site [nucleotide binding]; other site
866895008222	Esterase/lipase [General function prediction only]; Region: COG1647
866895008223	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866895008224	Preprotein translocase SecG subunit; Region: SecG; cl09123
866895008225	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866895008226	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866895008227	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866895008228	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
866895008229	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
866895008230	putative substrate binding site [chemical binding]; other site
866895008231	putative ATP binding site [chemical binding]; other site
866895008232	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866895008233	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
866895008234	active site
866895008235	phosphorylation site [posttranslational modification]
866895008236	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
866895008237	active site
866895008238	P-loop; other site
866895008239	phosphorylation site [posttranslational modification]
866895008240	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
866895008241	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866895008242	dimerization domain swap beta strand [polypeptide binding]; other site
866895008243	regulatory protein interface [polypeptide binding]; other site
866895008244	active site
866895008245	regulatory phosphorylation site [posttranslational modification]; other site
866895008246	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
866895008247	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
866895008248	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
866895008249	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
866895008250	Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606
866895008251	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
866895008252	putative FMN binding site [chemical binding]; other site
866895008253	Uncharacterized conserved protein [Function unknown]; Region: COG1434
866895008254	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
866895008255	putative active site [active]
866895008256	enolase; Provisional; Region: eno; PRK00077
866895008257	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
866895008258	dimer interface [polypeptide binding]; other site
866895008259	metal binding site [ion binding]; metal-binding site
866895008260	substrate binding pocket [chemical binding]; other site
866895008261	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
866895008262	phosphoglyceromutase; Provisional; Region: PRK05434
866895008263	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
866895008264	triosephosphate isomerase; Provisional; Region: PRK14565
866895008265	substrate binding site [chemical binding]; other site
866895008266	dimer interface [polypeptide binding]; other site
866895008267	catalytic triad [active]
866895008268	Phosphoglycerate kinase; Region: PGK; pfam00162
866895008269	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
866895008270	substrate binding site [chemical binding]; other site
866895008271	hinge regions; other site
866895008272	ADP binding site [chemical binding]; other site
866895008273	catalytic site [active]
866895008274	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
866895008275	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
866895008276	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
866895008277	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
866895008278	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
866895008279	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
866895008280	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895008281	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895008282	Probable transposase; Region: OrfB_IS605; pfam01385
866895008283	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895008284	Clp protease; Region: CLP_protease; pfam00574
866895008285	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
866895008286	oligomer interface [polypeptide binding]; other site
866895008287	active site residues [active]
866895008288	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866895008289	dimerization domain swap beta strand [polypeptide binding]; other site
866895008290	regulatory protein interface [polypeptide binding]; other site
866895008291	active site
866895008292	regulatory phosphorylation site [posttranslational modification]; other site
866895008293	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
866895008294	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
866895008295	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
866895008296	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
866895008297	phosphate binding site [ion binding]; other site
866895008298	putative substrate binding pocket [chemical binding]; other site
866895008299	dimer interface [polypeptide binding]; other site
866895008300	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
866895008301	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
866895008302	putative active site [active]
866895008303	nucleotide binding site [chemical binding]; other site
866895008304	nudix motif; other site
866895008305	putative metal binding site [ion binding]; other site
866895008306	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
866895008307	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895008308	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895008309	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895008310	binding surface
866895008311	TPR motif; other site
866895008312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895008313	binding surface
866895008314	TPR motif; other site
866895008315	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
866895008316	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
866895008317	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
866895008318	metal binding site [ion binding]; metal-binding site
866895008319	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
866895008320	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
866895008321	substrate binding site [chemical binding]; other site
866895008322	glutamase interaction surface [polypeptide binding]; other site
866895008323	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
866895008324	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
866895008325	catalytic residues [active]
866895008326	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
866895008327	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
866895008328	putative active site [active]
866895008329	oxyanion strand; other site
866895008330	catalytic triad [active]
866895008331	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
866895008332	putative active site pocket [active]
866895008333	4-fold oligomerization interface [polypeptide binding]; other site
866895008334	metal binding residues [ion binding]; metal-binding site
866895008335	3-fold/trimer interface [polypeptide binding]; other site
866895008336	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
866895008337	histidinol dehydrogenase; Region: hisD; TIGR00069
866895008338	NAD binding site [chemical binding]; other site
866895008339	dimerization interface [polypeptide binding]; other site
866895008340	product binding site; other site
866895008341	substrate binding site [chemical binding]; other site
866895008342	zinc binding site [ion binding]; other site
866895008343	catalytic residues [active]
866895008344	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
866895008345	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
866895008346	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
866895008347	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
866895008348	dimer interface [polypeptide binding]; other site
866895008349	motif 1; other site
866895008350	active site
866895008351	motif 2; other site
866895008352	motif 3; other site
866895008353	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866895008354	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895008355	active site
866895008356	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
866895008357	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
866895008358	acyl-activating enzyme (AAE) consensus motif; other site
866895008359	AMP binding site [chemical binding]; other site
866895008360	active site
866895008361	CoA binding site [chemical binding]; other site
866895008362	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
866895008363	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
866895008364	DNA binding residues [nucleotide binding]
866895008365	putative dimer interface [polypeptide binding]; other site
866895008366	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
866895008367	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895008368	glycerol kinase; Provisional; Region: glpK; PRK00047
866895008369	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
866895008370	N- and C-terminal domain interface [polypeptide binding]; other site
866895008371	active site
866895008372	MgATP binding site [chemical binding]; other site
866895008373	catalytic site [active]
866895008374	metal binding site [ion binding]; metal-binding site
866895008375	glycerol binding site [chemical binding]; other site
866895008376	homotetramer interface [polypeptide binding]; other site
866895008377	homodimer interface [polypeptide binding]; other site
866895008378	FBP binding site [chemical binding]; other site
866895008379	protein IIAGlc interface [polypeptide binding]; other site
866895008380	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
866895008381	amphipathic channel; other site
866895008382	Asn-Pro-Ala signature motifs; other site
866895008383	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
866895008384	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
866895008385	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
866895008386	trimer interface [polypeptide binding]; other site
866895008387	active site
866895008388	substrate binding site [chemical binding]; other site
866895008389	CoA binding site [chemical binding]; other site
866895008390	pyrophosphatase PpaX; Provisional; Region: PRK13288
866895008391	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895008392	motif II; other site
866895008393	Nucleoside recognition; Region: Gate; pfam07670
866895008394	Nucleoside recognition; Region: Gate; pfam07670
866895008395	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
866895008396	HPr kinase/phosphorylase; Provisional; Region: PRK05428
866895008397	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
866895008398	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
866895008399	Hpr binding site; other site
866895008400	active site
866895008401	homohexamer subunit interaction site [polypeptide binding]; other site
866895008402	Predicted membrane protein [Function unknown]; Region: COG1950
866895008403	Uncharacterized conserved protein [Function unknown]; Region: COG3595
866895008404	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
866895008405	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
866895008406	Protein of unknown function (DUF1806); Region: DUF1806; pfam08830
866895008407	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
866895008408	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
866895008409	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
866895008410	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
866895008411	excinuclease ABC subunit B; Provisional; Region: PRK05298
866895008412	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895008413	ATP binding site [chemical binding]; other site
866895008414	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895008415	nucleotide binding region [chemical binding]; other site
866895008416	ATP-binding site [chemical binding]; other site
866895008417	Ultra-violet resistance protein B; Region: UvrB; pfam12344
866895008418	UvrB/uvrC motif; Region: UVR; pfam02151
866895008419	HAMP domain; Region: HAMP; pfam00672
866895008420	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895008421	PAS domain; Region: PAS_9; pfam13426
866895008422	putative active site [active]
866895008423	heme pocket [chemical binding]; other site
866895008424	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
866895008425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866895008426	dimer interface [polypeptide binding]; other site
866895008427	phosphorylation site [posttranslational modification]
866895008428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895008429	ATP binding site [chemical binding]; other site
866895008430	Mg2+ binding site [ion binding]; other site
866895008431	G-X-G motif; other site
866895008432	Response regulator receiver domain; Region: Response_reg; pfam00072
866895008433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895008434	active site
866895008435	phosphorylation site [posttranslational modification]
866895008436	intermolecular recognition site; other site
866895008437	dimerization interface [polypeptide binding]; other site
866895008438	Response regulator receiver domain; Region: Response_reg; pfam00072
866895008439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895008440	active site
866895008441	phosphorylation site [posttranslational modification]
866895008442	intermolecular recognition site; other site
866895008443	dimerization interface [polypeptide binding]; other site
866895008444	Response regulator receiver domain; Region: Response_reg; pfam00072
866895008445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895008446	active site
866895008447	phosphorylation site [posttranslational modification]
866895008448	intermolecular recognition site; other site
866895008449	dimerization interface [polypeptide binding]; other site
866895008450	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866895008451	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866895008452	metal binding site [ion binding]; metal-binding site
866895008453	active site
866895008454	I-site; other site
866895008455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895008456	Response regulator receiver domain; Region: Response_reg; pfam00072
866895008457	active site
866895008458	phosphorylation site [posttranslational modification]
866895008459	intermolecular recognition site; other site
866895008460	dimerization interface [polypeptide binding]; other site
866895008461	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
866895008462	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
866895008463	G1 box; other site
866895008464	putative GEF interaction site [polypeptide binding]; other site
866895008465	GTP/Mg2+ binding site [chemical binding]; other site
866895008466	Switch I region; other site
866895008467	G2 box; other site
866895008468	G3 box; other site
866895008469	Switch II region; other site
866895008470	G4 box; other site
866895008471	G5 box; other site
866895008472	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
866895008473	SWIM zinc finger; Region: SWIM; pfam04434
866895008474	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
866895008475	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
866895008476	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895008477	ATP binding site [chemical binding]; other site
866895008478	putative Mg++ binding site [ion binding]; other site
866895008479	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895008480	nucleotide binding region [chemical binding]; other site
866895008481	ATP-binding site [chemical binding]; other site
866895008482	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895008483	non-specific DNA binding site [nucleotide binding]; other site
866895008484	salt bridge; other site
866895008485	sequence-specific DNA binding site [nucleotide binding]; other site
866895008486	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
866895008487	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
866895008488	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
866895008489	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
866895008490	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
866895008491	putative active site [active]
866895008492	putative metal binding site [ion binding]; other site
866895008493	Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102
866895008494	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
866895008495	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895008496	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
866895008497	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
866895008498	Walker A/P-loop; other site
866895008499	ATP binding site [chemical binding]; other site
866895008500	Q-loop/lid; other site
866895008501	ABC transporter signature motif; other site
866895008502	Walker B; other site
866895008503	D-loop; other site
866895008504	H-loop/switch region; other site
866895008505	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866895008506	protein binding site [polypeptide binding]; other site
866895008507	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
866895008508	C-terminal peptidase (prc); Region: prc; TIGR00225
866895008509	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
866895008510	protein binding site [polypeptide binding]; other site
866895008511	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
866895008512	Catalytic dyad [active]
866895008513	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
866895008514	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
866895008515	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895008516	motif II; other site
866895008517	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
866895008518	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866895008519	catalytic residue [active]
866895008520	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
866895008521	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895008522	Walker A/P-loop; other site
866895008523	ATP binding site [chemical binding]; other site
866895008524	Q-loop/lid; other site
866895008525	ABC transporter signature motif; other site
866895008526	Walker B; other site
866895008527	D-loop; other site
866895008528	H-loop/switch region; other site
866895008529	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
866895008530	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
866895008531	Uncharacterized conserved protein [Function unknown]; Region: COG1284
866895008532	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
866895008533	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
866895008534	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
866895008535	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
866895008536	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
866895008537	active site
866895008538	tetramer interface; other site
866895008539	peptide chain release factor 2; Provisional; Region: PRK06746
866895008540	This domain is found in peptide chain release factors; Region: PCRF; smart00937
866895008541	RF-1 domain; Region: RF-1; pfam00472
866895008542	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
866895008543	DEAD/DEAH box helicase; Region: DEAD; pfam00270
866895008544	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
866895008545	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895008546	nucleotide binding region [chemical binding]; other site
866895008547	ATP-binding site [chemical binding]; other site
866895008548	SEC-C motif; Region: SEC-C; pfam02810
866895008549	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
866895008550	30S subunit binding site; other site
866895008551	Flagellar protein FliT; Region: FliT; pfam05400
866895008552	flagellar protein FliS; Validated; Region: fliS; PRK05685
866895008553	flagellar capping protein; Validated; Region: fliD; PRK07737
866895008554	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
866895008555	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
866895008556	carbon storage regulator; Provisional; Region: PRK01712
866895008557	flagellar assembly protein FliW; Provisional; Region: PRK13285
866895008558	Fijivirus 64 kDa capsid protein; Region: Fiji_64_capsid; pfam05880
866895008559	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
866895008560	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
866895008561	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
866895008562	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
866895008563	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
866895008564	FlgN protein; Region: FlgN; pfam05130
866895008565	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
866895008566	flagellar operon protein TIGR03826; Region: YvyF
866895008567	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
866895008568	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895008569	active site
866895008570	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
866895008571	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895008572	ATP binding site [chemical binding]; other site
866895008573	putative Mg++ binding site [ion binding]; other site
866895008574	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895008575	nucleotide binding region [chemical binding]; other site
866895008576	ATP-binding site [chemical binding]; other site
866895008577	EDD domain protein, DegV family; Region: DegV; TIGR00762
866895008578	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
866895008579	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895008580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895008581	active site
866895008582	phosphorylation site [posttranslational modification]
866895008583	intermolecular recognition site; other site
866895008584	dimerization interface [polypeptide binding]; other site
866895008585	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895008586	DNA binding residues [nucleotide binding]
866895008587	dimerization interface [polypeptide binding]; other site
866895008588	Sensor protein DegS; Region: DegS; pfam05384
866895008589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866895008590	Histidine kinase; Region: HisKA_3; pfam07730
866895008591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895008592	ATP binding site [chemical binding]; other site
866895008593	Mg2+ binding site [ion binding]; other site
866895008594	G-X-G motif; other site
866895008595	Uncharacterized conserved protein [Function unknown]; Region: COG1739
866895008596	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
866895008597	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
866895008598	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
866895008599	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
866895008600	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
866895008601	Mg++ binding site [ion binding]; other site
866895008602	putative catalytic motif [active]
866895008603	substrate binding site [chemical binding]; other site
866895008604	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
866895008605	Lamin Tail Domain; Region: LTD; pfam00932
866895008606	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
866895008607	generic binding surface I; other site
866895008608	generic binding surface II; other site
866895008609	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
866895008610	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
866895008611	generic binding surface I; other site
866895008612	generic binding surface II; other site
866895008613	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
866895008614	putative active site [active]
866895008615	putative catalytic site [active]
866895008616	putative Mg binding site IVb [ion binding]; other site
866895008617	putative phosphate binding site [ion binding]; other site
866895008618	putative DNA binding site [nucleotide binding]; other site
866895008619	putative Mg binding site IVa [ion binding]; other site
866895008620	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
866895008621	Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556
866895008622	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
866895008623	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
866895008624	active site
866895008625	homodimer interface [polypeptide binding]; other site
866895008626	catalytic site [active]
866895008627	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
866895008628	starch-binding site 1 [chemical binding]; other site
866895008629	S-layer homology domain; Region: SLH; pfam00395
866895008630	S-layer homology domain; Region: SLH; pfam00395
866895008631	S-layer homology domain; Region: SLH; pfam00395
866895008632	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
866895008633	putative active site [active]
866895008634	putative metal binding site [ion binding]; other site
866895008635	UDP-glucose 4-epimerase; Region: PLN02240
866895008636	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
866895008637	NAD binding site [chemical binding]; other site
866895008638	homodimer interface [polypeptide binding]; other site
866895008639	active site
866895008640	substrate binding site [chemical binding]; other site
866895008641	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
866895008642	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
866895008643	GAF domain; Region: GAF_3; pfam13492
866895008644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866895008645	binding surface
866895008646	TPR motif; other site
866895008647	Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960
866895008648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878
866895008649	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
866895008650	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
866895008651	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895008652	Predicted membrane protein [Function unknown]; Region: COG4267
866895008653	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
866895008654	Sulfatase; Region: Sulfatase; pfam00884
866895008655	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895008656	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895008657	DNA binding site [nucleotide binding]
866895008658	domain linker motif; other site
866895008659	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
866895008660	putative dimerization interface [polypeptide binding]; other site
866895008661	putative ligand binding site [chemical binding]; other site
866895008662	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866895008663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895008664	dimer interface [polypeptide binding]; other site
866895008665	conserved gate region; other site
866895008666	putative PBP binding loops; other site
866895008667	ABC-ATPase subunit interface; other site
866895008668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895008669	dimer interface [polypeptide binding]; other site
866895008670	conserved gate region; other site
866895008671	ABC-ATPase subunit interface; other site
866895008672	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
866895008673	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866895008674	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
866895008675	homodimer interface [polypeptide binding]; other site
866895008676	maltodextrin glucosidase; Provisional; Region: PRK10785
866895008677	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
866895008678	active site
866895008679	homodimer interface [polypeptide binding]; other site
866895008680	catalytic site [active]
866895008681	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
866895008682	catalytic residue [active]
866895008683	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
866895008684	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
866895008685	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
866895008686	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
866895008687	Glutamate binding site [chemical binding]; other site
866895008688	homodimer interface [polypeptide binding]; other site
866895008689	NAD binding site [chemical binding]; other site
866895008690	catalytic residues [active]
866895008691	Proline dehydrogenase; Region: Pro_dh; cl03282
866895008692	PRC-barrel domain; Region: PRC; pfam05239
866895008693	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
866895008694	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
866895008695	Nucleotide binding site [chemical binding]; other site
866895008696	DTAP/Switch II; other site
866895008697	Switch I; other site
866895008698	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
866895008699	Carbon starvation protein CstA; Region: CstA; pfam02554
866895008700	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
866895008701	Gas vesicle protein; Region: Gas_vesicle; pfam00741
866895008702	Gas vesicle protein K; Region: GvpK; pfam05121
866895008703	Gas vesicle protein; Region: Gas_vesicle; pfam00741
866895008704	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
866895008705	Gas vesicle protein G; Region: GvpG; pfam05120
866895008706	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
866895008707	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866895008708	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
866895008709	Walker A motif; other site
866895008710	ATP binding site [chemical binding]; other site
866895008711	Walker B motif; other site
866895008712	arginine finger; other site
866895008713	Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800
866895008714	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
866895008715	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
866895008716	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
866895008717	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
866895008718	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
866895008719	Acyltransferase family; Region: Acyl_transf_3; pfam01757
866895008720	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
866895008721	putative substrate binding pocket [chemical binding]; other site
866895008722	AC domain interface; other site
866895008723	catalytic triad [active]
866895008724	AB domain interface; other site
866895008725	interchain disulfide; other site
866895008726	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
866895008727	GAF domain; Region: GAF; cl17456
866895008728	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
866895008729	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895008730	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
866895008731	Predicted membrane protein [Function unknown]; Region: COG1289
866895008732	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
866895008733	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866895008734	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866895008735	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866895008736	putative active site [active]
866895008737	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866895008738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895008739	dimer interface [polypeptide binding]; other site
866895008740	conserved gate region; other site
866895008741	putative PBP binding loops; other site
866895008742	ABC-ATPase subunit interface; other site
866895008743	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866895008744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895008745	dimer interface [polypeptide binding]; other site
866895008746	conserved gate region; other site
866895008747	putative PBP binding loops; other site
866895008748	ABC-ATPase subunit interface; other site
866895008749	carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851
866895008750	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
866895008751	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
866895008752	putative active site [active]
866895008753	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866895008754	nucleotide binding site [chemical binding]; other site
866895008755	Uncharacterized conserved protein [Function unknown]; Region: COG2353
866895008756	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
866895008757	active site
866895008758	PQQ-like domain; Region: PQQ_2; pfam13360
866895008759	Trp docking motif [polypeptide binding]; other site
866895008760	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
866895008761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895008762	putative substrate translocation pore; other site
866895008763	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
866895008764	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895008765	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895008766	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
866895008767	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895008768	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
866895008769	active site
866895008770	Predicted membrane protein [Function unknown]; Region: COG4640
866895008771	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
866895008772	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
866895008773	Double zinc ribbon; Region: DZR; pfam12773
866895008774	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
866895008775	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
866895008776	RDD family; Region: RDD; pfam06271
866895008777	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
866895008778	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866895008779	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895008780	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895008781	Probable transposase; Region: OrfB_IS605; pfam01385
866895008782	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895008783	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
866895008784	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895008785	motif II; other site
866895008786	murein hydrolase B; Provisional; Region: PRK10760; cl17906
866895008787	hypothetical protein; Provisional; Region: PRK05463
866895008788	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
866895008789	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
866895008790	Ca binding site [ion binding]; other site
866895008791	active site
866895008792	catalytic site [active]
866895008793	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
866895008794	acetylornithine deacetylase; Validated; Region: PRK06915
866895008795	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
866895008796	metal binding site [ion binding]; metal-binding site
866895008797	dimer interface [polypeptide binding]; other site
866895008798	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
866895008799	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
866895008800	hypothetical protein; Provisional; Region: PRK06917
866895008801	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895008802	inhibitor-cofactor binding pocket; inhibition site
866895008803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895008804	catalytic residue [active]
866895008805	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
866895008806	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
866895008807	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
866895008808	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
866895008809	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
866895008810	active site
866895008811	tetramer interface; other site
866895008812	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
866895008813	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
866895008814	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
866895008815	putative active site [active]
866895008816	putative substrate binding site [chemical binding]; other site
866895008817	putative cosubstrate binding site; other site
866895008818	catalytic site [active]
866895008819	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895008820	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
866895008821	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866895008822	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895008823	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866895008824	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895008825	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866895008826	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895008827	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
866895008828	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
866895008829	putative NAD(P) binding site [chemical binding]; other site
866895008830	putative active site [active]
866895008831	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
866895008832	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
866895008833	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
866895008834	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
866895008835	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
866895008836	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
866895008837	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
866895008838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895008839	active site
866895008840	phosphorylation site [posttranslational modification]
866895008841	intermolecular recognition site; other site
866895008842	dimerization interface [polypeptide binding]; other site
866895008843	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
866895008844	PAS domain; Region: PAS; smart00091
866895008845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895008846	ATP binding site [chemical binding]; other site
866895008847	Mg2+ binding site [ion binding]; other site
866895008848	G-X-G motif; other site
866895008849	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
866895008850	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
866895008851	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
866895008852	Predicted dehydrogenase [General function prediction only]; Region: COG0579
866895008853	hydroxyglutarate oxidase; Provisional; Region: PRK11728
866895008854	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
866895008855	substrate binding pocket [chemical binding]; other site
866895008856	active site
866895008857	iron coordination sites [ion binding]; other site
866895008858	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
866895008859	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
866895008860	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
866895008861	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
866895008862	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
866895008863	active site
866895008864	Zn binding site [ion binding]; other site
866895008865	3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640
866895008866	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866895008867	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
866895008868	metal binding site [ion binding]; metal-binding site
866895008869	dimer interface [polypeptide binding]; other site
866895008870	Nuclease-related domain; Region: NERD; pfam08378
866895008871	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895008872	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895008873	active site
866895008874	catalytic tetrad [active]
866895008875	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
866895008876	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
866895008877	AsnC family; Region: AsnC_trans_reg; pfam01037
866895008878	hypothetical protein; Validated; Region: PRK07682
866895008879	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866895008880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895008881	homodimer interface [polypeptide binding]; other site
866895008882	catalytic residue [active]
866895008883	S-layer homology domain; Region: SLH; pfam00395
866895008884	S-layer homology domain; Region: SLH; pfam00395
866895008885	S-layer homology domain; Region: SLH; pfam00395
866895008886	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866895008887	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895008888	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895008889	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
866895008890	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895008891	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895008892	DNA binding residues [nucleotide binding]
866895008893	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
866895008894	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
866895008895	active site
866895008896	catalytic residues [active]
866895008897	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
866895008898	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
866895008899	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
866895008900	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895008901	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895008902	DNA binding site [nucleotide binding]
866895008903	domain linker motif; other site
866895008904	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866895008905	dimerization interface [polypeptide binding]; other site
866895008906	ligand binding site [chemical binding]; other site
866895008907	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
866895008908	proposed catalytic triad [active]
866895008909	active site nucleophile [active]
866895008910	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
866895008911	proposed catalytic triad [active]
866895008912	active site nucleophile [active]
866895008913	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
866895008914	beta-galactosidase; Region: BGL; TIGR03356
866895008915	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866895008916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895008917	dimer interface [polypeptide binding]; other site
866895008918	conserved gate region; other site
866895008919	putative PBP binding loops; other site
866895008920	ABC-ATPase subunit interface; other site
866895008921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895008922	dimer interface [polypeptide binding]; other site
866895008923	conserved gate region; other site
866895008924	putative PBP binding loops; other site
866895008925	ABC-ATPase subunit interface; other site
866895008926	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866895008927	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866895008928	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
866895008929	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
866895008930	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866895008931	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866895008932	catalytic residue [active]
866895008933	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
866895008934	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
866895008935	active site
866895008936	FMN binding site [chemical binding]; other site
866895008937	substrate binding site [chemical binding]; other site
866895008938	putative catalytic residue [active]
866895008939	Low molecular weight phosphatase family; Region: LMWPc; cd00115
866895008940	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
866895008941	active site
866895008942	arsenical pump membrane protein; Provisional; Region: PRK15445
866895008943	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
866895008944	transmembrane helices; other site
866895008945	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895008946	dimerization interface [polypeptide binding]; other site
866895008947	putative DNA binding site [nucleotide binding]; other site
866895008948	putative Zn2+ binding site [ion binding]; other site
866895008949	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
866895008950	non-specific DNA binding site [nucleotide binding]; other site
866895008951	salt bridge; other site
866895008952	sequence-specific DNA binding site [nucleotide binding]; other site
866895008953	transglutaminase; Provisional; Region: tgl; PRK03187
866895008954	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
866895008955	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
866895008956	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
866895008957	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
866895008958	putative active site [active]
866895008959	putative metal binding site [ion binding]; other site
866895008960	Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102
866895008961	poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012
866895008962	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895008963	Protein of unknown function, DUF606; Region: DUF606; pfam04657
866895008964	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
866895008965	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
866895008966	ligand binding site [chemical binding]; other site
866895008967	flexible hinge region; other site
866895008968	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
866895008969	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
866895008970	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
866895008971	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
866895008972	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895008973	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
866895008974	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
866895008975	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
866895008976	SpoOM protein; Region: Spo0M; pfam07070
866895008977	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
866895008978	hydrophobic ligand binding site; other site
866895008979	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
866895008980	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
866895008981	DNA binding residues [nucleotide binding]
866895008982	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866895008983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895008984	S-adenosylmethionine binding site [chemical binding]; other site
866895008985	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
866895008986	Helix-turn-helix domain; Region: HTH_17; cl17695
866895008987	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895008988	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895008989	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
866895008990	Protein export membrane protein; Region: SecD_SecF; cl14618
866895008991	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895008992	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895008993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
866895008994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895008995	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895008996	putative substrate translocation pore; other site
866895008997	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866895008998	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
866895008999	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866895009000	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
866895009001	catalytic site [active]
866895009002	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
866895009003	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
866895009004	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866895009005	NAD binding site [chemical binding]; other site
866895009006	dimer interface [polypeptide binding]; other site
866895009007	substrate binding site [chemical binding]; other site
866895009008	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
866895009009	L-lactate permease; Region: Lactate_perm; cl00701
866895009010	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895009011	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
866895009012	active site
866895009013	metal binding site [ion binding]; metal-binding site
866895009014	Predicted transcriptional regulators [Transcription]; Region: COG1733
866895009015	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
866895009016	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
866895009017	hypothetical protein; Provisional; Region: PRK07588
866895009018	hypothetical protein; Provisional; Region: PRK07236
866895009019	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866895009020	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866895009021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
866895009022	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
866895009023	active site
866895009024	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
866895009025	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
866895009026	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
866895009027	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
866895009028	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895009029	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895009030	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
866895009031	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
866895009032	NodB motif; other site
866895009033	active site
866895009034	catalytic site [active]
866895009035	metal binding site [ion binding]; metal-binding site
866895009036	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
866895009037	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895009038	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
866895009039	Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash.  The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838
866895009040	catalytic triad [active]
866895009041	oxyanion hole [active]
866895009042	active site
866895009043	RDD family; Region: RDD; pfam06271
866895009044	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
866895009045	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866895009046	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
866895009047	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
866895009048	EamA-like transporter family; Region: EamA; pfam00892
866895009049	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
866895009050	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866895009051	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895009052	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
866895009053	active site
866895009054	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
866895009055	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895009056	cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104
866895009057	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
866895009058	Predicted transcriptional regulators [Transcription]; Region: COG1695
866895009059	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
866895009060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895009061	Coenzyme A binding pocket [chemical binding]; other site
866895009062	Beta-lactamase; Region: Beta-lactamase; pfam00144
866895009063	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
866895009064	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
866895009065	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
866895009066	dimer interface [polypeptide binding]; other site
866895009067	active site
866895009068	metal binding site [ion binding]; metal-binding site
866895009069	Pathogenicity locus; Region: Cdd1; pfam11731
866895009070	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
866895009071	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
866895009072	Phosphotransferase enzyme family; Region: APH; pfam01636
866895009073	active site
866895009074	substrate binding site [chemical binding]; other site
866895009075	ATP binding site [chemical binding]; other site
866895009076	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866895009077	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
866895009078	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895009079	putative DNA binding site [nucleotide binding]; other site
866895009080	dimerization interface [polypeptide binding]; other site
866895009081	putative Zn2+ binding site [ion binding]; other site
866895009082	DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817
866895009083	Predicted transcriptional regulators [Transcription]; Region: COG1695
866895009084	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
866895009085	UreD urease accessory protein; Region: UreD; cl00530
866895009086	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866895009087	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
866895009088	UreF; Region: UreF; pfam01730
866895009089	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
866895009090	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
866895009091	dimer interface [polypeptide binding]; other site
866895009092	catalytic residues [active]
866895009093	urease subunit alpha; Reviewed; Region: ureC; PRK13207
866895009094	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
866895009095	subunit interactions [polypeptide binding]; other site
866895009096	active site
866895009097	flap region; other site
866895009098	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
866895009099	gamma-beta subunit interface [polypeptide binding]; other site
866895009100	alpha-beta subunit interface [polypeptide binding]; other site
866895009101	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
866895009102	alpha-gamma subunit interface [polypeptide binding]; other site
866895009103	beta-gamma subunit interface [polypeptide binding]; other site
866895009104	Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476
866895009105	Na binding site [ion binding]; other site
866895009106	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866895009107	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866895009108	ABC-ATPase subunit  interface; other site
866895009109	dimer interface [polypeptide binding]; other site
866895009110	putative PBP binding regions; other site
866895009111	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
866895009112	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
866895009113	Walker A/P-loop; other site
866895009114	ATP binding site [chemical binding]; other site
866895009115	Q-loop/lid; other site
866895009116	ABC transporter signature motif; other site
866895009117	Walker B; other site
866895009118	D-loop; other site
866895009119	H-loop/switch region; other site
866895009120	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
866895009121	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
866895009122	intersubunit interface [polypeptide binding]; other site
866895009123	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895009124	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895009125	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
866895009126	active site
866895009127	NTP binding site [chemical binding]; other site
866895009128	metal binding triad [ion binding]; metal-binding site
866895009129	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
866895009130	Ferritin-like domain; Region: Ferritin; pfam00210
866895009131	ferroxidase diiron center [ion binding]; other site
866895009132	Uncharacterized conserved protein [Function unknown]; Region: COG1633
866895009133	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
866895009134	dinuclear metal binding motif [ion binding]; other site
866895009135	Methyltransferase domain; Region: Methyltransf_31; pfam13847
866895009136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895009137	S-adenosylmethionine binding site [chemical binding]; other site
866895009138	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
866895009139	Domain of unknown function DUF21; Region: DUF21; pfam01595
866895009140	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866895009141	Transporter associated domain; Region: CorC_HlyC; pfam03471
866895009142	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
866895009143	Domain of unknown function DUF21; Region: DUF21; pfam01595
866895009144	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866895009145	Transporter associated domain; Region: CorC_HlyC; smart01091
866895009146	SpoOM protein; Region: Spo0M; pfam07070
866895009147	allantoate amidohydrolase; Reviewed; Region: PRK09290
866895009148	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
866895009149	active site
866895009150	metal binding site [ion binding]; metal-binding site
866895009151	dimer interface [polypeptide binding]; other site
866895009152	DoxX-like family; Region: DoxX_2; pfam13564
866895009153	Peptidase family M23; Region: Peptidase_M23; pfam01551
866895009154	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
866895009155	HTH domain; Region: HTH_11; pfam08279
866895009156	PRD domain; Region: PRD; pfam00874
866895009157	PRD domain; Region: PRD; pfam00874
866895009158	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
866895009159	active site
866895009160	P-loop; other site
866895009161	phosphorylation site [posttranslational modification]
866895009162	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866895009163	active site
866895009164	phosphorylation site [posttranslational modification]
866895009165	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
866895009166	active site
866895009167	P-loop; other site
866895009168	phosphorylation site [posttranslational modification]
866895009169	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
866895009170	short chain dehydrogenase; Provisional; Region: PRK06197
866895009171	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
866895009172	putative NAD(P) binding site [chemical binding]; other site
866895009173	active site
866895009174	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
866895009175	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
866895009176	putative metal binding site [ion binding]; other site
866895009177	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
866895009178	active site
866895009179	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
866895009180	classical (c) SDRs; Region: SDR_c; cd05233
866895009181	NAD(P) binding site [chemical binding]; other site
866895009182	active site
866895009183	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
866895009184	Na binding site [ion binding]; other site
866895009185	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866895009186	catalytic core [active]
866895009187	Predicted ATPase [General function prediction only]; Region: COG3910
866895009188	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895009189	Walker A/P-loop; other site
866895009190	ATP binding site [chemical binding]; other site
866895009191	Q-loop/lid; other site
866895009192	ABC transporter signature motif; other site
866895009193	Walker B; other site
866895009194	D-loop; other site
866895009195	H-loop/switch region; other site
866895009196	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866895009197	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866895009198	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895009199	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895009200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895009201	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
866895009202	putative substrate translocation pore; other site
866895009203	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
866895009204	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
866895009205	active site
866895009206	NAD binding site [chemical binding]; other site
866895009207	metal binding site [ion binding]; metal-binding site
866895009209	bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019
866895009210	Predicted integral membrane protein [Function unknown]; Region: COG5652
866895009211	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
866895009212	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
866895009213	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866895009214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895009215	dimer interface [polypeptide binding]; other site
866895009216	conserved gate region; other site
866895009217	putative PBP binding loops; other site
866895009218	ABC-ATPase subunit interface; other site
866895009219	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
866895009220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895009221	dimer interface [polypeptide binding]; other site
866895009222	putative PBP binding loops; other site
866895009223	ABC-ATPase subunit interface; other site
866895009224	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866895009225	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866895009226	Protein of unknown function, DUF624; Region: DUF624; cl02369
866895009227	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895009228	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895009229	DNA binding site [nucleotide binding]
866895009230	domain linker motif; other site
866895009231	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866895009232	dimerization interface [polypeptide binding]; other site
866895009233	ligand binding site [chemical binding]; other site
866895009234	Helix-turn-helix domain; Region: HTH_36; pfam13730
866895009235	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
866895009237	Protein of unknown function DUF91; Region: DUF91; cl00709
866895009238	EVE domain; Region: EVE; cl00728
866895009239	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
866895009240	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895009241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895009242	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895009243	Probable transposase; Region: OrfB_IS605; pfam01385
866895009244	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
866895009245	DctM-like transporters; Region: DctM; pfam06808
866895009246	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
866895009247	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
866895009248	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
866895009249	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
866895009250	Transcriptional regulators [Transcription]; Region: GntR; COG1802
866895009251	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895009252	DNA-binding site [nucleotide binding]; DNA binding site
866895009253	FCD domain; Region: FCD; pfam07729
866895009254	RDD family; Region: RDD; pfam06271
866895009255	RDD family; Region: RDD; pfam06271
866895009256	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866895009257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895009258	non-specific DNA binding site [nucleotide binding]; other site
866895009259	salt bridge; other site
866895009260	sequence-specific DNA binding site [nucleotide binding]; other site
866895009261	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
866895009262	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
866895009263	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
866895009264	HSP70 interaction site [polypeptide binding]; other site
866895009265	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
866895009266	Protein of unknown function (DUF3260); Region: DUF3260; cl11881
866895009267	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
866895009268	O-Antigen ligase; Region: Wzy_C; pfam04932
866895009269	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
866895009270	ATP-sulfurylase; Region: ATPS; cd00517
866895009271	active site
866895009272	HXXH motif; other site
866895009273	flexible loop; other site
866895009274	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
866895009275	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
866895009276	active site
866895009277	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
866895009278	ligand-binding site [chemical binding]; other site
866895009279	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
866895009280	transmembrane helices; other site
866895009281	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
866895009282	TrkA-C domain; Region: TrkA_C; pfam02080
866895009283	TrkA-C domain; Region: TrkA_C; pfam02080
866895009284	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
866895009285	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895009286	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
866895009287	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
866895009288	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
866895009289	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
866895009290	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
866895009291	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
866895009292	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
866895009293	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
866895009294	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866895009295	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895009296	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866895009297	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
866895009298	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
866895009299	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895009300	NAD(P) binding site [chemical binding]; other site
866895009301	active site
866895009302	Bacterial sugar transferase; Region: Bac_transf; pfam02397
866895009303	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
866895009304	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
866895009305	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866895009306	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
866895009307	Chain length determinant protein; Region: Wzz; cl15801
866895009308	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866895009309	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895009310	S-layer homology domain; Region: SLH; pfam00395
866895009311	S-layer homology domain; Region: SLH; pfam00395
866895009312	S-layer homology domain; Region: SLH; pfam00395
866895009313	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
866895009314	putative active site [active]
866895009315	catalytic triad [active]
866895009316	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
866895009317	PA/protease domain interface [polypeptide binding]; other site
866895009318	putative integrin binding motif; other site
866895009319	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
866895009320	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
866895009321	S-layer homology domain; Region: SLH; pfam00395
866895009322	S-layer homology domain; Region: SLH; pfam00395
866895009323	S-layer homology domain; Region: SLH; pfam00395
866895009324	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
866895009325	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
866895009326	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895009327	nucleotide binding region [chemical binding]; other site
866895009328	ATP-binding site [chemical binding]; other site
866895009329	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
866895009330	active site
866895009331	catalytic triad [active]
866895009332	S-layer homology domain; Region: SLH; pfam00395
866895009333	S-layer homology domain; Region: SLH; pfam00395
866895009334	S-layer homology domain; Region: SLH; pfam00395
866895009335	S-layer homology domain; Region: SLH; pfam00395
866895009336	S-layer homology domain; Region: SLH; pfam00395
866895009337	S-layer homology domain; Region: SLH; pfam00395
866895009338	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866895009339	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
866895009340	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
866895009341	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
866895009342	S-layer homology domain; Region: SLH; pfam00395
866895009343	S-layer homology domain; Region: SLH; pfam00395
866895009344	S-layer homology domain; Region: SLH; pfam00395
866895009345	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
866895009346	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
866895009347	active site
866895009348	metal binding site [ion binding]; metal-binding site
866895009349	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
866895009350	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
866895009351	active site
866895009352	catalytic residues [active]
866895009353	S-layer homology domain; Region: SLH; pfam00395
866895009354	S-layer homology domain; Region: SLH; pfam00395
866895009355	S-layer homology domain; Region: SLH; pfam00395
866895009356	S-layer homology domain; Region: SLH; pfam00395
866895009357	S-layer homology domain; Region: SLH; pfam00395
866895009358	S-layer homology domain; Region: SLH; pfam00395
866895009359	Bacterial SH3 domain; Region: SH3_3; pfam08239
866895009360	Bacterial SH3 domain; Region: SH3_3; pfam08239
866895009361	Bacterial SH3 domain; Region: SH3_3; pfam08239
866895009362	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
866895009363	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
866895009364	active site
866895009365	metal binding site [ion binding]; metal-binding site
866895009366	S-layer homology domain; Region: SLH; pfam00395
866895009367	S-layer homology domain; Region: SLH; pfam00395
866895009368	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
866895009369	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
866895009370	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
866895009371	stage V sporulation protein B; Region: spore_V_B; TIGR02900
866895009372	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
866895009373	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
866895009374	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
866895009375	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
866895009376	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866895009377	dimerization interface [polypeptide binding]; other site
866895009378	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
866895009379	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
866895009380	dimer interface [polypeptide binding]; other site
866895009381	putative CheW interface [polypeptide binding]; other site
866895009382	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
866895009383	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
866895009384	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
866895009385	metal-binding site [ion binding]
866895009386	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
866895009387	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866895009388	putative active site [active]
866895009389	putative metal binding site [ion binding]; other site
866895009390	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
866895009391	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
866895009392	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
866895009393	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
866895009394	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
866895009395	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
866895009396	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
866895009397	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
866895009398	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866895009399	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
866895009400	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895009401	Coenzyme A binding pocket [chemical binding]; other site
866895009402	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
866895009403	Amidohydrolase; Region: Amidohydro_2; pfam04909
866895009404	active site
866895009405	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
866895009406	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895009407	Coenzyme A binding pocket [chemical binding]; other site
866895009408	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
866895009409	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
866895009410	Chromate transporter; Region: Chromate_transp; pfam02417
866895009411	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866895009412	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
866895009413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895009414	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895009415	putative substrate translocation pore; other site
866895009416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895009417	putative substrate translocation pore; other site
866895009418	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
866895009419	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
866895009420	Mg++ binding site [ion binding]; other site
866895009421	putative catalytic motif [active]
866895009422	substrate binding site [chemical binding]; other site
866895009423	Anti-repressor SinI; Region: SinI; pfam08671
866895009424	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895009425	non-specific DNA binding site [nucleotide binding]; other site
866895009426	salt bridge; other site
866895009427	sequence-specific DNA binding site [nucleotide binding]; other site
866895009428	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
866895009429	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866895009430	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866895009431	Anti-repressor SinI; Region: SinI; pfam08671
866895009432	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
866895009433	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
866895009434	active site
866895009435	substrate binding site [chemical binding]; other site
866895009436	metal binding site [ion binding]; metal-binding site
866895009437	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
866895009438	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
866895009439	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
866895009440	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866895009441	active site turn [active]
866895009442	phosphorylation site [posttranslational modification]
866895009443	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866895009444	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895009445	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895009446	DNA binding site [nucleotide binding]
866895009447	domain linker motif; other site
866895009448	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
866895009449	dimerization interface [polypeptide binding]; other site
866895009450	ligand binding site [chemical binding]; other site
866895009451	homoserine dehydrogenase; Provisional; Region: PRK06349
866895009452	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
866895009453	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
866895009454	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
866895009455	threonine synthase; Reviewed; Region: PRK06721
866895009456	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
866895009457	homodimer interface [polypeptide binding]; other site
866895009458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895009459	catalytic residue [active]
866895009460	homoserine kinase; Provisional; Region: PRK01212
866895009461	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866895009462	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
866895009463	Predicted integral membrane protein [Function unknown]; Region: COG5652
866895009464	RNA polymerase factor sigma-70; Validated; Region: PRK06759
866895009465	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866895009466	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
866895009467	Predicted permeases [General function prediction only]; Region: COG0679
866895009468	Transposase IS200 like; Region: Y1_Tnp; pfam01797
866895009469	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
866895009470	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866895009471	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866895009472	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866895009473	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866895009474	putative active site [active]
866895009475	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
866895009476	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
866895009477	Na binding site [ion binding]; other site
866895009478	Predicted membrane protein [Function unknown]; Region: COG4327
866895009479	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
866895009480	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
866895009481	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
866895009482	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
866895009483	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
866895009484	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
866895009485	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
866895009486	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
866895009487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895009488	putative substrate translocation pore; other site
866895009489	Predicted transcriptional regulator [Transcription]; Region: COG4189
866895009490	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895009491	putative DNA binding site [nucleotide binding]; other site
866895009492	putative Zn2+ binding site [ion binding]; other site
866895009493	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
866895009494	Sodium Bile acid symporter family; Region: SBF; pfam01758
866895009495	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
866895009496	FAD binding domain; Region: FAD_binding_4; pfam01565
866895009497	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
866895009498	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
866895009499	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
866895009500	catalytic residues [active]
866895009501	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
866895009502	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
866895009503	Cysteine-rich domain; Region: CCG; pfam02754
866895009504	Cysteine-rich domain; Region: CCG; pfam02754
866895009505	FAD binding domain; Region: FAD_binding_4; pfam01565
866895009506	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
866895009507	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
866895009508	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
866895009509	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
866895009510	active site
866895009511	Zn binding site [ion binding]; other site
866895009512	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
866895009513	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
866895009514	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
866895009515	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
866895009516	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
866895009517	active site
866895009518	catalytic residues [active]
866895009519	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
866895009520	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
866895009521	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
866895009522	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
866895009523	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
866895009524	NAD binding site [chemical binding]; other site
866895009525	homodimer interface [polypeptide binding]; other site
866895009526	active site
866895009527	substrate binding site [chemical binding]; other site
866895009528	galactokinase; Provisional; Region: PRK05322
866895009529	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
866895009530	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866895009531	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
866895009532	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
866895009533	Melibiase; Region: Melibiase; pfam02065
866895009534	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866895009535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895009536	dimer interface [polypeptide binding]; other site
866895009537	conserved gate region; other site
866895009538	putative PBP binding loops; other site
866895009539	ABC-ATPase subunit interface; other site
866895009540	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866895009541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895009542	dimer interface [polypeptide binding]; other site
866895009543	conserved gate region; other site
866895009544	putative PBP binding loops; other site
866895009545	ABC-ATPase subunit interface; other site
866895009546	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866895009547	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866895009548	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866895009549	dimerization interface [polypeptide binding]; other site
866895009550	putative DNA binding site [nucleotide binding]; other site
866895009551	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
866895009552	putative Zn2+ binding site [ion binding]; other site
866895009553	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866895009554	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866895009555	nucleotide binding site [chemical binding]; other site
866895009556	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
866895009557	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
866895009558	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866895009559	nucleotide binding site [chemical binding]; other site
866895009560	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
866895009561	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
866895009562	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
866895009563	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866895009564	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866895009565	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
866895009566	putative dimerization interface [polypeptide binding]; other site
866895009567	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
866895009568	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
866895009569	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
866895009570	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
866895009571	Ligand binding site; other site
866895009572	Putative Catalytic site; other site
866895009573	DXD motif; other site
866895009574	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
866895009575	Protein of unknown function, DUF624; Region: DUF624; cl02369
866895009576	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
866895009577	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
866895009578	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866895009579	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895009580	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866895009581	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895009582	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866895009583	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
866895009584	conserved cys residue [active]
866895009585	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895009586	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895009587	DNA binding site [nucleotide binding]
866895009588	domain linker motif; other site
866895009589	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
866895009590	putative dimerization interface [polypeptide binding]; other site
866895009591	putative ligand binding site [chemical binding]; other site
866895009592	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866895009593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895009594	dimer interface [polypeptide binding]; other site
866895009595	conserved gate region; other site
866895009596	putative PBP binding loops; other site
866895009597	ABC-ATPase subunit interface; other site
866895009598	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895009599	dimer interface [polypeptide binding]; other site
866895009600	conserved gate region; other site
866895009601	putative PBP binding loops; other site
866895009602	ABC-ATPase subunit interface; other site
866895009603	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866895009604	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
866895009605	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
866895009606	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
866895009607	putative dimer interface [polypeptide binding]; other site
866895009608	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
866895009609	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866895009610	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895009611	non-specific DNA binding site [nucleotide binding]; other site
866895009612	salt bridge; other site
866895009613	sequence-specific DNA binding site [nucleotide binding]; other site
866895009614	Anti-repressor SinI; Region: SinI; pfam08671
866895009615	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
866895009616	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866895009617	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895009618	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895009619	Walker A/P-loop; other site
866895009620	ATP binding site [chemical binding]; other site
866895009621	Q-loop/lid; other site
866895009622	ABC transporter signature motif; other site
866895009623	Walker B; other site
866895009624	D-loop; other site
866895009625	H-loop/switch region; other site
866895009626	PilZ domain; Region: PilZ; pfam07238
866895009627	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
866895009628	active site
866895009629	putative catalytic site [active]
866895009630	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
866895009631	Protein export membrane protein; Region: SecD_SecF; cl14618
866895009632	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
866895009633	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
866895009634	HlyD family secretion protein; Region: HlyD_3; pfam13437
866895009635	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
866895009636	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866895009637	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866895009638	catalytic residue [active]
866895009639	Bacterial SH3 domain; Region: SH3_3; pfam08239
866895009640	S-layer homology domain; Region: SLH; pfam00395
866895009641	S-layer homology domain; Region: SLH; pfam00395
866895009642	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
866895009643	Methyltransferase domain; Region: Methyltransf_31; pfam13847
866895009644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895009645	S-adenosylmethionine binding site [chemical binding]; other site
866895009646	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
866895009647	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
866895009648	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
866895009649	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
866895009650	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
866895009651	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
866895009652	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
866895009653	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
866895009654	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
866895009655	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
866895009656	rod shape-determining protein Mbl; Provisional; Region: PRK13928
866895009657	MreB and similar proteins; Region: MreB_like; cd10225
866895009658	nucleotide binding site [chemical binding]; other site
866895009659	Mg binding site [ion binding]; other site
866895009660	putative protofilament interaction site [polypeptide binding]; other site
866895009661	RodZ interaction site [polypeptide binding]; other site
866895009662	Stage III sporulation protein D; Region: SpoIIID; pfam12116
866895009663	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
866895009664	Peptidase family M23; Region: Peptidase_M23; pfam01551
866895009665	stage II sporulation protein D; Region: spore_II_D; TIGR02870
866895009666	Stage II sporulation protein; Region: SpoIID; pfam08486
866895009667	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
866895009668	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
866895009669	hinge; other site
866895009670	active site
866895009671	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
866895009672	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
866895009673	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
866895009674	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
866895009675	gamma subunit interface [polypeptide binding]; other site
866895009676	epsilon subunit interface [polypeptide binding]; other site
866895009677	LBP interface [polypeptide binding]; other site
866895009678	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
866895009679	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866895009680	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
866895009681	alpha subunit interaction interface [polypeptide binding]; other site
866895009682	Walker A motif; other site
866895009683	ATP binding site [chemical binding]; other site
866895009684	Walker B motif; other site
866895009685	inhibitor binding site; inhibition site
866895009686	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866895009687	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
866895009688	core domain interface [polypeptide binding]; other site
866895009689	delta subunit interface [polypeptide binding]; other site
866895009690	epsilon subunit interface [polypeptide binding]; other site
866895009691	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
866895009692	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866895009693	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
866895009694	beta subunit interaction interface [polypeptide binding]; other site
866895009695	Walker A motif; other site
866895009696	ATP binding site [chemical binding]; other site
866895009697	Walker B motif; other site
866895009698	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866895009699	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
866895009700	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
866895009701	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
866895009702	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
866895009703	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
866895009704	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
866895009705	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
866895009706	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
866895009707	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
866895009708	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
866895009709	putative active site [active]
866895009710	catalytic triad [active]
866895009711	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
866895009712	putative integrin binding motif; other site
866895009713	PA/protease domain interface [polypeptide binding]; other site
866895009714	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
866895009715	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
866895009716	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
866895009717	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
866895009718	active site
866895009719	homodimer interface [polypeptide binding]; other site
866895009720	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
866895009721	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866895009722	N-terminal domain interface [polypeptide binding]; other site
866895009723	active site
866895009724	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
866895009725	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
866895009726	dimer interface [polypeptide binding]; other site
866895009727	active site
866895009728	glycine-pyridoxal phosphate binding site [chemical binding]; other site
866895009729	folate binding site [chemical binding]; other site
866895009730	hypothetical protein; Provisional; Region: PRK13690
866895009731	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
866895009732	Low molecular weight phosphatase family; Region: LMWPc; cd00115
866895009733	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
866895009734	active site
866895009735	Predicted membrane protein [Function unknown]; Region: COG1971
866895009736	Domain of unknown function DUF; Region: DUF204; pfam02659
866895009737	Domain of unknown function DUF; Region: DUF204; pfam02659
866895009738	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
866895009739	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
866895009740	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
866895009741	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
866895009742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895009743	S-adenosylmethionine binding site [chemical binding]; other site
866895009744	peptide chain release factor 1; Validated; Region: prfA; PRK00591
866895009745	This domain is found in peptide chain release factors; Region: PCRF; smart00937
866895009746	RF-1 domain; Region: RF-1; pfam00472
866895009747	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
866895009748	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
866895009749	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
866895009750	thymidine kinase; Provisional; Region: PRK04296
866895009751	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
866895009752	transcription termination factor Rho; Provisional; Region: rho; PRK09376
866895009753	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
866895009754	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
866895009755	RNA binding site [nucleotide binding]; other site
866895009756	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866895009757	Walker A motif; other site
866895009758	ATP binding site [chemical binding]; other site
866895009759	Walker B motif; other site
866895009760	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
866895009761	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
866895009762	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
866895009763	hinge; other site
866895009764	active site
866895009765	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
866895009766	active site
866895009767	intersubunit interactions; other site
866895009768	catalytic residue [active]
866895009769	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
866895009770	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
866895009771	intersubunit interface [polypeptide binding]; other site
866895009772	active site
866895009773	zinc binding site [ion binding]; other site
866895009774	Na+ binding site [ion binding]; other site
866895009775	Response regulator receiver domain; Region: Response_reg; pfam00072
866895009776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895009777	active site
866895009778	phosphorylation site [posttranslational modification]
866895009779	intermolecular recognition site; other site
866895009780	dimerization interface [polypeptide binding]; other site
866895009781	CTP synthetase; Validated; Region: pyrG; PRK05380
866895009782	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
866895009783	Catalytic site [active]
866895009784	active site
866895009785	UTP binding site [chemical binding]; other site
866895009786	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
866895009787	active site
866895009788	putative oxyanion hole; other site
866895009789	catalytic triad [active]
866895009790	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
866895009791	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
866895009792	B12 binding site [chemical binding]; other site
866895009793	cobalt ligand [ion binding]; other site
866895009794	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
866895009795	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866895009796	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
866895009797	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895009798	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895009799	ArgK protein; Region: ArgK; pfam03308
866895009800	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
866895009801	Walker A; other site
866895009802	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895009803	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
866895009804	FAD binding site [chemical binding]; other site
866895009805	homotetramer interface [polypeptide binding]; other site
866895009806	substrate binding pocket [chemical binding]; other site
866895009807	catalytic base [active]
866895009808	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895009809	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
866895009810	FAD binding site [chemical binding]; other site
866895009811	homotetramer interface [polypeptide binding]; other site
866895009812	substrate binding pocket [chemical binding]; other site
866895009813	catalytic base [active]
866895009814	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
866895009815	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
866895009816	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
866895009817	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
866895009818	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866895009819	dimer interface [polypeptide binding]; other site
866895009820	active site
866895009821	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
866895009822	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
866895009823	4Fe-4S binding domain; Region: Fer4_2; pfam12797
866895009824	Cysteine-rich domain; Region: CCG; pfam02754
866895009825	Cysteine-rich domain; Region: CCG; pfam02754
866895009826	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
866895009827	PLD-like domain; Region: PLDc_2; pfam13091
866895009828	putative active site [active]
866895009829	catalytic site [active]
866895009830	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
866895009831	PLD-like domain; Region: PLDc_2; pfam13091
866895009832	putative active site [active]
866895009833	catalytic site [active]
866895009834	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
866895009835	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
866895009836	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
866895009837	active site
866895009838	HIGH motif; other site
866895009839	KMSK motif region; other site
866895009840	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
866895009841	tRNA binding surface [nucleotide binding]; other site
866895009842	anticodon binding site; other site
866895009843	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
866895009844	agmatinase; Region: agmatinase; TIGR01230
866895009845	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
866895009846	putative active site [active]
866895009847	Mn binding site [ion binding]; other site
866895009848	spermidine synthase; Provisional; Region: PRK00811
866895009849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895009850	Transglycosylase; Region: Transgly; pfam00912
866895009851	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
866895009852	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
866895009853	YolD-like protein; Region: YolD; pfam08863
866895009854	YwhD family; Region: YwhD; pfam08741
866895009855	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
866895009856	Uncharacterized conserved protein [Function unknown]; Region: COG3465
866895009857	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
866895009858	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866895009859	Zn2+ binding site [ion binding]; other site
866895009860	Mg2+ binding site [ion binding]; other site
866895009861	Hemolytic toxin N terminal; Region: Hemolysin_N; pfam12563
866895009862	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
866895009863	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
866895009864	putative heme peroxidase; Provisional; Region: PRK12276
866895009865	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
866895009866	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
866895009867	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
866895009868	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
866895009869	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
866895009870	Na2 binding site [ion binding]; other site
866895009871	putative substrate binding site 1 [chemical binding]; other site
866895009872	Na binding site 1 [ion binding]; other site
866895009873	putative substrate binding site 2 [chemical binding]; other site
866895009874	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
866895009875	Uncharacterized conserved protein [Function unknown]; Region: COG3937
866895009876	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
866895009877	ABC1 family; Region: ABC1; cl17513
866895009878	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
866895009879	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895009880	Coenzyme A binding pocket [chemical binding]; other site
866895009881	Phosphotransferase enzyme family; Region: APH; pfam01636
866895009882	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
866895009883	active site
866895009884	ATP binding site [chemical binding]; other site
866895009885	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
866895009886	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
866895009887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
866895009888	Nucleoside recognition; Region: Gate; pfam07670
866895009889	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
866895009890	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
866895009891	potential catalytic triad [active]
866895009892	conserved cys residue [active]
866895009893	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
866895009894	Acyltransferase family; Region: Acyl_transf_3; pfam01757
866895009895	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
866895009896	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
866895009897	Predicted membrane protein [Function unknown]; Region: COG4325
866895009898	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
866895009899	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
866895009900	DNA photolyase; Region: DNA_photolyase; pfam00875
866895009901	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
866895009902	homopentamer interface [polypeptide binding]; other site
866895009903	active site
866895009904	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
866895009905	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
866895009906	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
866895009907	dimerization interface [polypeptide binding]; other site
866895009908	active site
866895009909	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
866895009910	Lumazine binding domain; Region: Lum_binding; pfam00677
866895009911	Lumazine binding domain; Region: Lum_binding; pfam00677
866895009912	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
866895009913	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
866895009914	catalytic motif [active]
866895009915	Zn binding site [ion binding]; other site
866895009916	RibD C-terminal domain; Region: RibD_C; cl17279
866895009917	YolD-like protein; Region: YolD; pfam08863
866895009918	WYL domain; Region: WYL; cl14852
866895009919	Part of AAA domain; Region: AAA_19; pfam13245
866895009920	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
866895009921	Family description; Region: UvrD_C_2; pfam13538
866895009922	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
866895009923	putative active site [active]
866895009924	putative metal-binding site [ion binding]; other site
866895009926	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895009927	AAA domain; Region: AAA_23; pfam13476
866895009928	Walker A/P-loop; other site
866895009929	ATP binding site [chemical binding]; other site
866895009930	Uncharacterized conserved protein [Function unknown]; Region: COG4938
866895009931	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
866895009932	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
866895009933	Toprim-like; Region: Toprim_2; pfam13155
866895009934	active site
866895009935	metal binding site [ion binding]; metal-binding site
866895009936	Domain of unknown function (DUF955); Region: DUF955; pfam06114
866895009937	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
866895009938	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
866895009939	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
866895009940	N-acetyl-D-glucosamine binding site [chemical binding]; other site
866895009941	catalytic residue [active]
866895009942	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
866895009943	Peptidase family M23; Region: Peptidase_M23; pfam01551
866895009944	AAA-like domain; Region: AAA_10; pfam12846
866895009945	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866895009946	Walker A motif; other site
866895009947	ATP binding site [chemical binding]; other site
866895009948	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
866895009949	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
866895009950	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
866895009951	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
866895009952	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
866895009953	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
866895009954	Helix-turn-helix domain; Region: HTH_17; cl17695
866895009955	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895009956	non-specific DNA binding site [nucleotide binding]; other site
866895009957	salt bridge; other site
866895009958	sequence-specific DNA binding site [nucleotide binding]; other site
866895009959	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866895009960	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895009961	non-specific DNA binding site [nucleotide binding]; other site
866895009962	salt bridge; other site
866895009963	sequence-specific DNA binding site [nucleotide binding]; other site
866895009964	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
866895009965	Abortive infection C-terminus; Region: Abi_C; pfam14355
866895009966	Predicted transcriptional regulators [Transcription]; Region: COG1695
866895009967	Transcriptional regulator PadR-like family; Region: PadR; cl17335
866895009968	Domain of unknown function (DUF955); Region: DUF955; pfam06114
866895009969	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
866895009970	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
866895009971	Int/Topo IB signature motif; other site
866895009972	Restriction endonuclease; Region: Mrr_cat; pfam04471
866895009973	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866895009974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895009975	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895009976	Probable transposase; Region: OrfB_IS605; pfam01385
866895009977	Glucan phosphorylase [Carbohydrate transport and metabolism]; Region: GlgP; COG0058
866895009978	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
866895009979	Mg binding site [ion binding]; other site
866895009980	nucleotide binding site [chemical binding]; other site
866895009981	putative protofilament interface [polypeptide binding]; other site
866895009982	Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612
866895009983	DNA polymerase IV; Reviewed; Region: PRK03103
866895009984	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
866895009985	active site
866895009986	DNA binding site [nucleotide binding]
866895009987	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
866895009988	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
866895009989	Ca binding site [ion binding]; other site
866895009990	active site
866895009991	catalytic site [active]
866895009992	peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563
866895009993	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
866895009994	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
866895009995	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895009996	Coenzyme A binding pocket [chemical binding]; other site
866895009997	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
866895009998	peptidase T; Region: peptidase-T; TIGR01882
866895009999	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
866895010000	metal binding site [ion binding]; metal-binding site
866895010001	dimer interface [polypeptide binding]; other site
866895010002	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
866895010003	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866895010004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895010005	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895010006	putative substrate translocation pore; other site
866895010007	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
866895010008	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
866895010009	DctM-like transporters; Region: DctM; pfam06808
866895010010	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
866895010011	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
866895010012	Predicted acetyltransferase [General function prediction only]; Region: COG3393
866895010013	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
866895010014	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
866895010015	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
866895010016	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
866895010017	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
866895010018	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
866895010019	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
866895010020	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
866895010021	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
866895010022	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
866895010023	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
866895010024	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
866895010025	putative NAD(P) binding site [chemical binding]; other site
866895010026	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
866895010027	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895010028	ATP binding site [chemical binding]; other site
866895010029	putative Mg++ binding site [ion binding]; other site
866895010030	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895010031	nucleotide binding region [chemical binding]; other site
866895010032	ATP-binding site [chemical binding]; other site
866895010033	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
866895010034	HRDC domain; Region: HRDC; pfam00570
866895010035	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
866895010036	kynureninase; Region: kynureninase; TIGR01814
866895010037	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866895010038	catalytic residue [active]
866895010039	Putative cyclase; Region: Cyclase; cl00814
866895010040	BCCT family transporter; Region: BCCT; pfam02028
866895010041	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895010042	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
866895010043	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
866895010044	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
866895010045	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
866895010046	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895010047	Walker A/P-loop; other site
866895010048	ATP binding site [chemical binding]; other site
866895010049	Q-loop/lid; other site
866895010050	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895010051	ABC transporter signature motif; other site
866895010052	Walker B; other site
866895010053	D-loop; other site
866895010054	ABC transporter; Region: ABC_tran_2; pfam12848
866895010055	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866895010056	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
866895010057	amino acid carrier protein; Region: agcS; TIGR00835
866895010058	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
866895010059	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
866895010060	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
866895010061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895010062	dimer interface [polypeptide binding]; other site
866895010063	conserved gate region; other site
866895010064	putative PBP binding loops; other site
866895010065	ABC-ATPase subunit interface; other site
866895010066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895010067	dimer interface [polypeptide binding]; other site
866895010068	conserved gate region; other site
866895010069	putative PBP binding loops; other site
866895010070	ABC-ATPase subunit interface; other site
866895010071	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
866895010072	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866895010073	Walker A/P-loop; other site
866895010074	ATP binding site [chemical binding]; other site
866895010075	Q-loop/lid; other site
866895010076	ABC transporter signature motif; other site
866895010077	Walker B; other site
866895010078	D-loop; other site
866895010079	H-loop/switch region; other site
866895010080	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
866895010081	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866895010082	HAMP domain; Region: HAMP; pfam00672
866895010083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866895010084	dimer interface [polypeptide binding]; other site
866895010085	phosphorylation site [posttranslational modification]
866895010086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895010087	ATP binding site [chemical binding]; other site
866895010088	Mg2+ binding site [ion binding]; other site
866895010089	G-X-G motif; other site
866895010090	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866895010091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895010092	active site
866895010093	phosphorylation site [posttranslational modification]
866895010094	intermolecular recognition site; other site
866895010095	dimerization interface [polypeptide binding]; other site
866895010096	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866895010097	DNA binding site [nucleotide binding]
866895010098	serine endoprotease; Provisional; Region: PRK10898
866895010099	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
866895010100	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866895010101	protein binding site [polypeptide binding]; other site
866895010102	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
866895010103	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
866895010104	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
866895010105	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
866895010106	putative active site [active]
866895010107	catalytic site [active]
866895010108	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
866895010109	putative active site [active]
866895010110	catalytic site [active]
866895010111	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
866895010112	HTH domain; Region: HTH_11; pfam08279
866895010113	3H domain; Region: 3H; pfam02829
866895010114	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
866895010115	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
866895010116	substrate binding [chemical binding]; other site
866895010117	active site
866895010118	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
866895010119	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866895010120	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
866895010121	putative substrate binding site [chemical binding]; other site
866895010122	putative ATP binding site [chemical binding]; other site
866895010123	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
866895010124	HPr interaction site; other site
866895010125	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866895010126	active site
866895010127	phosphorylation site [posttranslational modification]
866895010128	methionine gamma-lyase; Provisional; Region: PRK06767
866895010129	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866895010130	homodimer interface [polypeptide binding]; other site
866895010131	substrate-cofactor binding pocket; other site
866895010132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895010133	catalytic residue [active]
866895010134	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
866895010135	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
866895010136	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
866895010137	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
866895010138	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
866895010139	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
866895010140	[2Fe-2S] cluster binding site [ion binding]; other site
866895010141	Predicted permeases [General function prediction only]; Region: RarD; COG2962
866895010142	EamA-like transporter family; Region: EamA; pfam00892
866895010143	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866895010144	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
866895010145	Probable transposase; Region: OrfB_IS605; pfam01385
866895010146	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
866895010147	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895010148	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895010149	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895010150	FAD binding domain; Region: FAD_binding_3; pfam01494
866895010151	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
866895010152	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
866895010153	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895010154	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895010155	active site
866895010156	catalytic tetrad [active]
866895010157	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
866895010158	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866895010159	Walker A/P-loop; other site
866895010160	ATP binding site [chemical binding]; other site
866895010161	Q-loop/lid; other site
866895010162	ABC transporter signature motif; other site
866895010163	Walker B; other site
866895010164	D-loop; other site
866895010165	H-loop/switch region; other site
866895010166	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
866895010167	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
866895010168	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866895010169	homodimer interface [polypeptide binding]; other site
866895010170	substrate-cofactor binding pocket; other site
866895010171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895010172	catalytic residue [active]
866895010173	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
866895010174	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
866895010175	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
866895010176	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
866895010177	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
866895010178	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
866895010179	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
866895010180	RQC domain; Region: RQC; pfam09382
866895010181	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
866895010182	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866895010183	active site
866895010184	dimer interface [polypeptide binding]; other site
866895010185	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895010186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895010187	active site
866895010188	phosphorylation site [posttranslational modification]
866895010189	intermolecular recognition site; other site
866895010190	dimerization interface [polypeptide binding]; other site
866895010191	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895010192	DNA binding residues [nucleotide binding]
866895010193	dimerization interface [polypeptide binding]; other site
866895010194	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866895010195	Histidine kinase; Region: HisKA_3; pfam07730
866895010196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895010197	ATP binding site [chemical binding]; other site
866895010198	Mg2+ binding site [ion binding]; other site
866895010199	G-X-G motif; other site
866895010200	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
866895010201	PspA/IM30 family; Region: PspA_IM30; pfam04012
866895010202	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
866895010203	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
866895010204	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
866895010205	active site
866895010206	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
866895010207	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
866895010208	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
866895010209	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
866895010210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895010211	S-adenosylmethionine binding site [chemical binding]; other site
866895010212	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
866895010213	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
866895010214	DEAD_2; Region: DEAD_2; pfam06733
866895010215	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
866895010216	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
866895010217	active site
866895010218	catalytic triad [active]
866895010219	oxyanion hole [active]
866895010220	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548
866895010221	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
866895010222	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
866895010223	dimer interface [polypeptide binding]; other site
866895010224	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895010225	catalytic residue [active]
866895010226	Predicted membrane protein [Function unknown]; Region: COG2860
866895010227	UPF0126 domain; Region: UPF0126; pfam03458
866895010228	UPF0126 domain; Region: UPF0126; pfam03458
866895010229	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895010230	sequence-specific DNA binding site [nucleotide binding]; other site
866895010231	salt bridge; other site
866895010232	PAS fold; Region: PAS_4; pfam08448
866895010233	Sporulation inhibitor A; Region: Sda; pfam08970
866895010234	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
866895010235	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
866895010236	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895010237	Zn binding site [ion binding]; other site
866895010238	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
866895010239	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895010240	Zn binding site [ion binding]; other site
866895010241	aconitate hydratase; Validated; Region: PRK07229
866895010242	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
866895010243	substrate binding site [chemical binding]; other site
866895010244	ligand binding site [chemical binding]; other site
866895010245	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
866895010246	substrate binding site [chemical binding]; other site
866895010247	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
866895010248	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
866895010249	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
866895010250	active site
866895010251	Zn binding site [ion binding]; other site
866895010252	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895010253	non-specific DNA binding site [nucleotide binding]; other site
866895010254	salt bridge; other site
866895010255	sequence-specific DNA binding site [nucleotide binding]; other site
866895010256	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
866895010257	TPR motif; other site
866895010258	Tetratricopeptide repeat; Region: TPR_12; pfam13424
866895010259	binding surface
866895010260	Protein of unknown function (DUF429); Region: DUF429; pfam04250
866895010261	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
866895010262	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866895010263	DNA-binding site [nucleotide binding]; DNA binding site
866895010264	UTRA domain; Region: UTRA; pfam07702
866895010265	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
866895010266	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
866895010267	Ca binding site [ion binding]; other site
866895010268	active site
866895010269	catalytic site [active]
866895010270	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
866895010271	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866895010272	active site turn [active]
866895010273	phosphorylation site [posttranslational modification]
866895010274	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866895010275	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
866895010276	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866895010277	HPr interaction site; other site
866895010278	active site
866895010279	phosphorylation site [posttranslational modification]
866895010280	drug efflux system protein MdtG; Provisional; Region: PRK09874
866895010281	Isochorismatase family; Region: Isochorismatase; pfam00857
866895010282	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
866895010283	catalytic triad [active]
866895010284	conserved cis-peptide bond; other site
866895010285	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
866895010286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895010287	putative substrate translocation pore; other site
866895010288	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
866895010289	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
866895010290	active site residue [active]
866895010291	Regulatory protein YrvL; Region: YrvL; pfam14184
866895010292	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
866895010293	catalytic triad [active]
866895010294	active site nucleophile [active]
866895010295	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
866895010296	substrate binding site [chemical binding]; other site
866895010297	dimer interface [polypeptide binding]; other site
866895010298	ATP binding site [chemical binding]; other site
866895010299	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
866895010300	DNA binding site [nucleotide binding]
866895010301	active site
866895010302	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
866895010303	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
866895010304	NADH(P)-binding; Region: NAD_binding_10; pfam13460
866895010305	NAD(P) binding site [chemical binding]; other site
866895010306	putative active site [active]
866895010307	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866895010308	non-specific DNA binding site [nucleotide binding]; other site
866895010309	salt bridge; other site
866895010310	sequence-specific DNA binding site [nucleotide binding]; other site
866895010311	Tetratricopeptide repeat; Region: TPR_12; pfam13424
866895010312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
866895010313	binding surface
866895010314	TPR motif; other site
866895010315	5'-3' exonuclease; Region: 53EXOc; smart00475
866895010316	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
866895010317	active site
866895010318	metal binding site 1 [ion binding]; metal-binding site
866895010319	putative 5' ssDNA interaction site; other site
866895010320	metal binding site 3; metal-binding site
866895010321	metal binding site 2 [ion binding]; metal-binding site
866895010322	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
866895010323	putative DNA binding site [nucleotide binding]; other site
866895010324	putative metal binding site [ion binding]; other site
866895010325	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
866895010326	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866895010327	NAD(P) binding site [chemical binding]; other site
866895010328	catalytic residues [active]
866895010329	Protein of unknown function (DUF779); Region: DUF779; pfam05610
866895010330	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866895010331	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895010332	Coenzyme A binding pocket [chemical binding]; other site
866895010333	Prostaglandin dehydrogenases; Region: PGDH; cd05288
866895010334	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
866895010335	NAD(P) binding site [chemical binding]; other site
866895010336	substrate binding site [chemical binding]; other site
866895010337	dimer interface [polypeptide binding]; other site
866895010338	BioY family; Region: BioY; pfam02632
866895010339	Protein of unknown function, DUF393; Region: DUF393; pfam04134
866895010340	aminodeoxychorismate synthase; Provisional; Region: PRK07508
866895010341	chorismate binding enzyme; Region: Chorismate_bind; cl10555
866895010342	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
866895010343	substrate-cofactor binding pocket; other site
866895010344	homodimer interface [polypeptide binding]; other site
866895010345	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
866895010346	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895010347	catalytic residue [active]
866895010348	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
866895010349	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
866895010350	glutamine binding [chemical binding]; other site
866895010351	catalytic triad [active]
866895010352	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866895010353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866895010354	dimer interface [polypeptide binding]; other site
866895010355	phosphorylation site [posttranslational modification]
866895010356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895010357	ATP binding site [chemical binding]; other site
866895010358	Mg2+ binding site [ion binding]; other site
866895010359	G-X-G motif; other site
866895010360	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
866895010361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895010362	active site
866895010363	phosphorylation site [posttranslational modification]
866895010364	intermolecular recognition site; other site
866895010365	dimerization interface [polypeptide binding]; other site
866895010366	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
866895010367	Bax inhibitor 1 like; Region: BaxI_1; cl17691
866895010368	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866895010369	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
866895010370	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895010371	putative substrate translocation pore; other site
866895010372	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
866895010373	nudix motif; other site
866895010374	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
866895010375	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
866895010376	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
866895010377	Amidase; Region: Amidase; pfam01425
866895010378	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
866895010379	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
866895010380	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866895010381	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
866895010382	ATP binding site [chemical binding]; other site
866895010383	Mg++ binding site [ion binding]; other site
866895010384	motif III; other site
866895010385	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895010386	nucleotide binding region [chemical binding]; other site
866895010387	ATP-binding site [chemical binding]; other site
866895010388	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
866895010389	hydrophobic ligand binding site; other site
866895010390	GAF domain; Region: GAF_3; pfam13492
866895010391	GAF domain; Region: GAF_2; pfam13185
866895010392	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
866895010393	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
866895010394	RDD family; Region: RDD; pfam06271
866895010395	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
866895010396	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
866895010397	dimer interface [polypeptide binding]; other site
866895010398	active site
866895010399	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866895010400	catalytic residues [active]
866895010401	substrate binding site [chemical binding]; other site
866895010402	IucA / IucC family; Region: IucA_IucC; pfam04183
866895010403	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
866895010404	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
866895010405	IucA / IucC family; Region: IucA_IucC; pfam04183
866895010406	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
866895010407	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
866895010408	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
866895010409	ornithine carbamoyltransferase; Provisional; Region: PRK00779
866895010410	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
866895010411	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
866895010412	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815
866895010413	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866895010414	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
866895010415	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
866895010416	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866895010417	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866895010418	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838
866895010419	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
866895010420	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
866895010421	catalytic site [active]
866895010422	subunit interface [polypeptide binding]; other site
866895010423	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
866895010424	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
866895010425	inhibitor-cofactor binding pocket; inhibition site
866895010426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895010427	catalytic residue [active]
866895010428	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
866895010429	nucleotide binding site [chemical binding]; other site
866895010430	N-acetyl-L-glutamate binding site [chemical binding]; other site
866895010431	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
866895010432	heterotetramer interface [polypeptide binding]; other site
866895010433	active site pocket [active]
866895010434	cleavage site
866895010435	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
866895010436	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
866895010437	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
866895010438	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895010439	NAD(P) binding site [chemical binding]; other site
866895010440	active site
866895010441	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
866895010442	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895010443	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866895010444	Coenzyme A binding pocket [chemical binding]; other site
866895010445	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
866895010446	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
866895010447	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
866895010448	Spore germination protein; Region: Spore_permease; cl17796
866895010449	nitrosocyanin; Region: nitroso_cyanin; TIGR03096
866895010450	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866895010451	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
866895010452	RNA binding surface [nucleotide binding]; other site
866895010453	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866895010454	active site
866895010455	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
866895010456	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
866895010457	active site
866895010458	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866895010459	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895010460	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
866895010461	Walker A/P-loop; other site
866895010462	ATP binding site [chemical binding]; other site
866895010463	Q-loop/lid; other site
866895010464	ABC transporter signature motif; other site
866895010465	Walker B; other site
866895010466	D-loop; other site
866895010467	H-loop/switch region; other site
866895010468	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866895010469	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866895010470	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895010471	Walker A/P-loop; other site
866895010472	ATP binding site [chemical binding]; other site
866895010473	Q-loop/lid; other site
866895010474	ABC transporter signature motif; other site
866895010475	Walker B; other site
866895010476	D-loop; other site
866895010477	H-loop/switch region; other site
866895010478	Predicted transcriptional regulators [Transcription]; Region: COG1733
866895010479	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
866895010480	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
866895010481	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
866895010482	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866895010483	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895010484	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
866895010485	active site
866895010486	catalytic triad [active]
866895010487	oxyanion hole [active]
866895010488	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
866895010489	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
866895010490	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866895010491	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
866895010492	NAD(P) binding site [chemical binding]; other site
866895010493	catalytic residues [active]
866895010494	homoserine dehydrogenase; Provisional; Region: PRK06270
866895010495	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
866895010496	NAD(P) binding pocket [chemical binding]; other site
866895010497	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
866895010498	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866895010499	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
866895010500	metal binding site [ion binding]; metal-binding site
866895010501	dimer interface [polypeptide binding]; other site
866895010502	cystathionine gamma-synthase; Provisional; Region: PRK08249
866895010503	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866895010504	homodimer interface [polypeptide binding]; other site
866895010505	substrate-cofactor binding pocket; other site
866895010506	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895010507	catalytic residue [active]
866895010508	ectoine utilization protein EutC; Validated; Region: PRK08291
866895010509	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
866895010510	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
866895010511	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
866895010512	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
866895010513	active site
866895010514	threonine synthase; Validated; Region: PRK08197
866895010515	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
866895010516	homodimer interface [polypeptide binding]; other site
866895010517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895010518	catalytic residue [active]
866895010519	BCCT family transporter; Region: BCCT; pfam02028
866895010520	short chain dehydrogenase; Provisional; Region: PRK06197
866895010521	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
866895010522	putative NAD(P) binding site [chemical binding]; other site
866895010523	active site
866895010524	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
866895010525	thiamine phosphate binding site [chemical binding]; other site
866895010526	active site
866895010527	pyrophosphate binding site [ion binding]; other site
866895010528	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
866895010529	substrate binding site [chemical binding]; other site
866895010530	multimerization interface [polypeptide binding]; other site
866895010531	ATP binding site [chemical binding]; other site
866895010532	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
866895010533	dimer interface [polypeptide binding]; other site
866895010534	substrate binding site [chemical binding]; other site
866895010535	ATP binding site [chemical binding]; other site
866895010536	Putative transcription activator [Transcription]; Region: TenA; COG0819
866895010537	thiW protein; Region: thiW; TIGR02359
866895010538	serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184
866895010539	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
866895010540	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
866895010541	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
866895010542	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
866895010543	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
866895010544	tetramer interface [polypeptide binding]; other site
866895010545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895010546	catalytic residue [active]
866895010547	asparagine synthetase B; Provisional; Region: asnB; PRK09431
866895010548	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
866895010549	active site
866895010550	dimer interface [polypeptide binding]; other site
866895010551	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
866895010552	Ligand Binding Site [chemical binding]; other site
866895010553	Molecular Tunnel; other site
866895010554	Fic/DOC family; Region: Fic; cl00960
866895010555	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
866895010556	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
866895010557	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
866895010558	putative DNA binding site [nucleotide binding]; other site
866895010559	putative homodimer interface [polypeptide binding]; other site
866895010560	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633
866895010561	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
866895010562	active site
866895010563	DNA binding site [nucleotide binding]
866895010564	LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866
866895010565	nucleotide binding site [chemical binding]; other site
866895010566	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
866895010567	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
866895010568	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
866895010569	acyl-activating enzyme (AAE) consensus motif; other site
866895010570	acyl-activating enzyme (AAE) consensus motif; other site
866895010571	putative AMP binding site [chemical binding]; other site
866895010572	putative active site [active]
866895010573	putative CoA binding site [chemical binding]; other site
866895010574	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
866895010575	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
866895010576	NAD binding site [chemical binding]; other site
866895010577	homodimer interface [polypeptide binding]; other site
866895010578	homotetramer interface [polypeptide binding]; other site
866895010579	active site
866895010580	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
866895010581	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866895010582	dimer interface [polypeptide binding]; other site
866895010583	active site
866895010584	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
866895010585	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866895010586	active site
866895010587	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
866895010588	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895010589	active site
866895010590	motif I; other site
866895010591	motif II; other site
866895010592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895010593	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866895010594	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
866895010595	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
866895010596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866895010597	dimer interface [polypeptide binding]; other site
866895010598	conserved gate region; other site
866895010599	ABC-ATPase subunit interface; other site
866895010600	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
866895010601	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
866895010602	Walker A/P-loop; other site
866895010603	ATP binding site [chemical binding]; other site
866895010604	Q-loop/lid; other site
866895010605	ABC transporter signature motif; other site
866895010606	Walker B; other site
866895010607	D-loop; other site
866895010608	H-loop/switch region; other site
866895010609	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
866895010610	Domain of unknown function DUF302; Region: DUF302; cl01364
866895010611	Predicted membrane protein [Function unknown]; Region: COG2323
866895010612	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
866895010613	putative homodimer interface [polypeptide binding]; other site
866895010614	putative homotetramer interface [polypeptide binding]; other site
866895010615	putative metal binding site [ion binding]; other site
866895010616	putative homodimer-homodimer interface [polypeptide binding]; other site
866895010617	putative allosteric switch controlling residues; other site
866895010618	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
866895010619	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866895010620	active site residue [active]
866895010621	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
866895010622	CPxP  motif; other site
866895010623	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866895010624	active site residue [active]
866895010625	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
866895010626	active site residue [active]
866895010627	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866895010628	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
866895010629	CPxP  motif; other site
866895010630	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
866895010631	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
866895010632	Sulfatase; Region: Sulfatase; pfam00884
866895010633	DinB family; Region: DinB; cl17821
866895010634	YrhK-like protein; Region: YrhK; pfam14145
866895010635	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
866895010636	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
866895010637	putative active site [active]
866895010638	putative metal binding site [ion binding]; other site
866895010639	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
866895010640	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
866895010641	D-pathway; other site
866895010642	Low-spin heme binding site [chemical binding]; other site
866895010643	Putative water exit pathway; other site
866895010644	Binuclear center (active site) [active]
866895010645	K-pathway; other site
866895010646	Putative proton exit pathway; other site
866895010647	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
866895010648	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
866895010649	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895010650	PAS domain; Region: PAS_9; pfam13426
866895010651	putative active site [active]
866895010652	heme pocket [chemical binding]; other site
866895010653	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866895010654	Histidine kinase; Region: HisKA_3; pfam07730
866895010655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895010656	ATP binding site [chemical binding]; other site
866895010657	Mg2+ binding site [ion binding]; other site
866895010658	G-X-G motif; other site
866895010659	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895010660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895010661	active site
866895010662	phosphorylation site [posttranslational modification]
866895010663	intermolecular recognition site; other site
866895010664	dimerization interface [polypeptide binding]; other site
866895010665	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895010666	DNA binding residues [nucleotide binding]
866895010667	dimerization interface [polypeptide binding]; other site
866895010668	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866895010669	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
866895010670	CHAD domain; Region: CHAD; pfam05235
866895010671	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
866895010672	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866895010673	Walker A/P-loop; other site
866895010674	ATP binding site [chemical binding]; other site
866895010675	Q-loop/lid; other site
866895010676	ABC transporter signature motif; other site
866895010677	Walker B; other site
866895010678	D-loop; other site
866895010679	H-loop/switch region; other site
866895010680	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
866895010681	Mg binding site [ion binding]; other site
866895010682	nucleotide binding site [chemical binding]; other site
866895010683	putative protofilament interface [polypeptide binding]; other site
866895010684	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
866895010685	active site
866895010686	catalytic residues [active]
866895010687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
866895010688	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
866895010689	Peptidase family M23; Region: Peptidase_M23; pfam01551
866895010690	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
866895010691	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
866895010692	aspartate racemase; Region: asp_race; TIGR00035
866895010693	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
866895010694	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
866895010695	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866895010696	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866895010697	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
866895010698	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
866895010699	hypothetical protein; Provisional; Region: PRK08201
866895010700	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
866895010701	metal binding site [ion binding]; metal-binding site
866895010702	putative dimer interface [polypeptide binding]; other site
866895010703	hydroperoxidase II; Provisional; Region: katE; PRK11249
866895010704	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
866895010705	tetramer interface [polypeptide binding]; other site
866895010706	heme binding pocket [chemical binding]; other site
866895010707	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
866895010708	domain interactions; other site
866895010709	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
866895010710	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895010711	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866895010712	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
866895010713	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
866895010714	active site
866895010715	dimer interface [polypeptide binding]; other site
866895010716	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
866895010717	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
866895010718	active site
866895010719	FMN binding site [chemical binding]; other site
866895010720	substrate binding site [chemical binding]; other site
866895010721	3Fe-4S cluster binding site [ion binding]; other site
866895010722	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
866895010723	domain interface; other site
866895010724	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
866895010725	homodimer interface [polypeptide binding]; other site
866895010726	homotetramer interface [polypeptide binding]; other site
866895010727	active site pocket [active]
866895010728	cleavage site
866895010729	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
866895010730	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
866895010731	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
866895010732	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
866895010733	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
866895010734	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
866895010735	pentamer interface [polypeptide binding]; other site
866895010736	dodecaamer interface [polypeptide binding]; other site
866895010737	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
866895010738	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
866895010739	active site
866895010740	homodimer interface [polypeptide binding]; other site
866895010741	catalytic site [active]
866895010742	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
866895010743	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
866895010744	active site pocket [active]
866895010745	glycogen synthase; Provisional; Region: glgA; PRK00654
866895010746	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
866895010747	ADP-binding pocket [chemical binding]; other site
866895010748	homodimer interface [polypeptide binding]; other site
866895010749	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
866895010750	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
866895010751	ligand binding site; other site
866895010752	oligomer interface; other site
866895010753	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
866895010754	dimer interface [polypeptide binding]; other site
866895010755	N-terminal domain interface [polypeptide binding]; other site
866895010756	sulfate 1 binding site; other site
866895010757	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
866895010758	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
866895010759	ligand binding site; other site
866895010760	oligomer interface; other site
866895010761	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
866895010762	dimer interface [polypeptide binding]; other site
866895010763	N-terminal domain interface [polypeptide binding]; other site
866895010764	sulfate 1 binding site; other site
866895010765	glycogen branching enzyme; Provisional; Region: PRK12313
866895010766	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
866895010767	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
866895010768	active site
866895010769	catalytic site [active]
866895010770	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
866895010771	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
866895010772	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
866895010773	YtxH-like protein; Region: YtxH; cl02079
866895010774	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866895010775	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
866895010776	NAD(P) binding site [chemical binding]; other site
866895010777	active site
866895010778	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
866895010779	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866895010780	Transposase; Region: HTH_Tnp_1; cl17663
866895010781	putative transposase OrfB; Reviewed; Region: PHA02517
866895010782	HTH-like domain; Region: HTH_21; pfam13276
866895010783	Integrase core domain; Region: rve; pfam00665
866895010784	Integrase core domain; Region: rve_3; pfam13683
866895010785	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
866895010786	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
866895010787	putative active site [active]
866895010788	putative substrate binding site [chemical binding]; other site
866895010789	putative FMN binding site [chemical binding]; other site
866895010790	putative catalytic residues [active]
866895010791	Transposase; Region: DEDD_Tnp_IS110; pfam01548
866895010792	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
866895010793	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
866895010794	H+ Antiporter protein; Region: 2A0121; TIGR00900
866895010795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895010796	putative substrate translocation pore; other site
866895010797	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866895010798	Ligand Binding Site [chemical binding]; other site
866895010799	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
866895010800	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866895010801	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866895010802	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
866895010803	active site residue [active]
866895010804	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
866895010805	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
866895010806	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
866895010807	hypothetical protein; Validated; Region: PRK07668
866895010808	Predicted transcriptional regulators [Transcription]; Region: COG1695
866895010809	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
866895010810	Protein of unknown function (DUF454); Region: DUF454; pfam04304
866895010811	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
866895010812	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
866895010813	putative di-iron ligands [ion binding]; other site
866895010814	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866895010815	Histidine kinase; Region: HisKA_3; pfam07730
866895010816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895010817	ATP binding site [chemical binding]; other site
866895010818	Mg2+ binding site [ion binding]; other site
866895010819	G-X-G motif; other site
866895010820	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895010821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895010822	active site
866895010823	phosphorylation site [posttranslational modification]
866895010824	intermolecular recognition site; other site
866895010825	dimerization interface [polypeptide binding]; other site
866895010826	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895010827	DNA binding residues [nucleotide binding]
866895010828	dimerization interface [polypeptide binding]; other site
866895010829	SurA N-terminal domain; Region: SurA_N_3; cl07813
866895010830	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
866895010831	dihydrodipicolinate synthase; Region: dapA; TIGR00674
866895010832	dimer interface [polypeptide binding]; other site
866895010833	active site
866895010834	catalytic residue [active]
866895010835	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895010836	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895010837	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866895010838	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
866895010839	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
866895010840	homodimer interface [polypeptide binding]; other site
866895010841	substrate-cofactor binding pocket; other site
866895010842	catalytic residue [active]
866895010843	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866895010844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895010845	active site
866895010846	phosphorylation site [posttranslational modification]
866895010847	intermolecular recognition site; other site
866895010848	dimerization interface [polypeptide binding]; other site
866895010849	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866895010850	DNA binding site [nucleotide binding]
866895010851	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866895010852	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895010853	ATP binding site [chemical binding]; other site
866895010854	Mg2+ binding site [ion binding]; other site
866895010855	G-X-G motif; other site
866895010856	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866895010857	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866895010858	Walker A/P-loop; other site
866895010859	ATP binding site [chemical binding]; other site
866895010860	Q-loop/lid; other site
866895010861	ABC transporter signature motif; other site
866895010862	Walker B; other site
866895010863	D-loop; other site
866895010864	H-loop/switch region; other site
866895010865	FtsX-like permease family; Region: FtsX; pfam02687
866895010866	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
866895010867	putative ADP-ribose binding site [chemical binding]; other site
866895010868	putative active site [active]
866895010869	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
866895010870	putative active site [active]
866895010871	putative CoA binding site [chemical binding]; other site
866895010872	nudix motif; other site
866895010873	metal binding site [ion binding]; metal-binding site
866895010874	Uncharacterized conserved protein [Function unknown]; Region: COG1633
866895010875	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
866895010876	dinuclear metal binding motif [ion binding]; other site
866895010877	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048
866895010878	diiron binding motif [ion binding]; other site
866895010879	PGAP1-like protein; Region: PGAP1; pfam07819
866895010880	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
866895010881	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
866895010882	NlpC/P60 family; Region: NLPC_P60; pfam00877
866895010883	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
866895010884	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
866895010885	active site
866895010886	PHP-associated; Region: PHP_C; pfam13263
866895010887	Cobalt transport protein; Region: CbiQ; cl00463
866895010888	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
866895010889	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866895010890	Walker A/P-loop; other site
866895010891	ATP binding site [chemical binding]; other site
866895010892	Q-loop/lid; other site
866895010893	ABC transporter signature motif; other site
866895010894	Walker B; other site
866895010895	D-loop; other site
866895010896	H-loop/switch region; other site
866895010897	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866895010898	Walker A/P-loop; other site
866895010899	ATP binding site [chemical binding]; other site
866895010900	Q-loop/lid; other site
866895010901	ABC transporter signature motif; other site
866895010902	Walker B; other site
866895010903	D-loop; other site
866895010904	H-loop/switch region; other site
866895010905	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866895010906	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866895010907	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866895010908	putative active site [active]
866895010909	malate:quinone oxidoreductase; Validated; Region: PRK05257
866895010910	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
866895010911	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866895010912	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866895010913	active site
866895010914	catalytic tetrad [active]
866895010915	Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171
866895010916	glutamate 5-kinase; Region: proB; TIGR01027
866895010917	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
866895010918	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
866895010919	putative active site [active]
866895010920	catalytic site [active]
866895010921	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
866895010922	putative active site [active]
866895010923	catalytic site [active]
866895010924	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
866895010925	active site
866895010926	metal binding site [ion binding]; metal-binding site
866895010927	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866895010928	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866895010929	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866895010930	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
866895010931	H+ Antiporter protein; Region: 2A0121; TIGR00900
866895010932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895010933	putative substrate translocation pore; other site
866895010934	putative transporter; Provisional; Region: PRK10484
866895010935	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
866895010936	Na binding site [ion binding]; other site
866895010937	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
866895010938	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
866895010939	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
866895010940	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
866895010941	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
866895010942	metal binding site [ion binding]; metal-binding site
866895010943	active site
866895010944	I-site; other site
866895010945	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866895010946	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
866895010947	PLD-like domain; Region: PLDc_2; pfam13091
866895010948	putative active site [active]
866895010949	catalytic site [active]
866895010950	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866895010951	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895010952	ATP binding site [chemical binding]; other site
866895010953	putative Mg++ binding site [ion binding]; other site
866895010954	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895010955	nucleotide binding region [chemical binding]; other site
866895010956	ATP-binding site [chemical binding]; other site
866895010957	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866895010958	DNA binding residues [nucleotide binding]
866895010959	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
866895010960	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
866895010961	putative homodimer interface [polypeptide binding]; other site
866895010962	putative active site [active]
866895010963	catalytic site [active]
866895010964	Protein of unknown function DUF91; Region: DUF91; cl00709
866895010965	Uncharacterized conserved protein [Function unknown]; Region: COG3586
866895010966	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
866895010967	Protein of unknown function (DUF524); Region: DUF524; pfam04411
866895010968	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
866895010969	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
866895010970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
866895010971	AAA domain; Region: AAA_11; pfam13086
866895010972	Part of AAA domain; Region: AAA_19; pfam13245
866895010973	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
866895010974	AAA domain; Region: AAA_12; pfam13087
866895010975	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
866895010976	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
866895010977	replicative DNA helicase; Region: DnaB; TIGR00665
866895010978	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
866895010979	Walker A motif; other site
866895010980	ATP binding site [chemical binding]; other site
866895010981	Walker B motif; other site
866895010982	DNA binding loops [nucleotide binding]
866895010983	Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417
866895010984	Helix-turn-helix domain; Region: HTH_36; pfam13730
866895010985	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
866895010986	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
866895010987	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
866895010988	FMN binding site [chemical binding]; other site
866895010989	active site
866895010990	catalytic residues [active]
866895010991	substrate binding site [chemical binding]; other site
866895010992	Uncharacterized conserved protein [Function unknown]; Region: COG4127
866895010993	Restriction endonuclease; Region: Mrr_cat; pfam04471
866895010994	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
866895010995	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866895010996	ATP binding site [chemical binding]; other site
866895010997	putative Mg++ binding site [ion binding]; other site
866895010998	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
866895010999	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866895011000	nucleotide binding region [chemical binding]; other site
866895011001	ATP-binding site [chemical binding]; other site
866895011002	TIGR02687 family protein; Region: TIGR02687
866895011003	PglZ domain; Region: PglZ; pfam08665
866895011004	Methyltransferase domain; Region: Methyltransf_26; pfam13659
866895011005	Methyltransferase domain; Region: Methyltransf_26; pfam13659
866895011006	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
866895011007	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
866895011008	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866895011009	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866895011010	Walker A/P-loop; other site
866895011011	ATP binding site [chemical binding]; other site
866895011012	Q-loop/lid; other site
866895011013	ABC transporter signature motif; other site
866895011014	Walker B; other site
866895011015	D-loop; other site
866895011016	H-loop/switch region; other site
866895011017	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
866895011018	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
866895011019	RDD family; Region: RDD; pfam06271
866895011020	alanine racemase; Reviewed; Region: alr; PRK00053
866895011021	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
866895011022	active site
866895011023	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866895011024	dimer interface [polypeptide binding]; other site
866895011025	substrate binding site [chemical binding]; other site
866895011026	catalytic residues [active]
866895011027	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
866895011028	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
866895011029	hexamer interface [polypeptide binding]; other site
866895011030	ligand binding site [chemical binding]; other site
866895011031	putative active site [active]
866895011032	NAD(P) binding site [chemical binding]; other site
866895011033	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
866895011034	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
866895011035	Uncharacterized membrane protein [Function unknown]; Region: COG3949
866895011036	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
866895011037	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
866895011038	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
866895011039	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
866895011040	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
866895011041	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
866895011042	ligand binding site [chemical binding]; other site
866895011043	dimerization interface [polypeptide binding]; other site
866895011044	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866895011045	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
866895011046	TM-ABC transporter signature motif; other site
866895011047	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
866895011048	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
866895011049	Walker A/P-loop; other site
866895011050	ATP binding site [chemical binding]; other site
866895011051	Q-loop/lid; other site
866895011052	ABC transporter signature motif; other site
866895011053	Walker B; other site
866895011054	D-loop; other site
866895011055	H-loop/switch region; other site
866895011056	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
866895011057	D-ribose pyranase; Provisional; Region: PRK11797
866895011058	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866895011059	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866895011060	substrate binding site [chemical binding]; other site
866895011061	dimer interface [polypeptide binding]; other site
866895011062	ATP binding site [chemical binding]; other site
866895011063	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866895011064	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866895011065	DNA binding site [nucleotide binding]
866895011066	domain linker motif; other site
866895011067	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
866895011068	dimerization interface [polypeptide binding]; other site
866895011069	ligand binding site [chemical binding]; other site
866895011070	Peptidase family M48; Region: Peptidase_M48; pfam01435
866895011071	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
866895011072	nudix motif; other site
866895011074	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
866895011075	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
866895011076	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
866895011077	tetramer interface [polypeptide binding]; other site
866895011078	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895011079	catalytic residue [active]
866895011080	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
866895011081	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
866895011082	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866895011083	protein binding site [polypeptide binding]; other site
866895011084	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
866895011085	YycH protein; Region: YycI; cl02015
866895011086	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
866895011087	YycH protein; Region: YycH; pfam07435
866895011088	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
866895011089	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866895011090	dimerization interface [polypeptide binding]; other site
866895011091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866895011092	putative active site [active]
866895011093	heme pocket [chemical binding]; other site
866895011094	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866895011095	dimer interface [polypeptide binding]; other site
866895011096	phosphorylation site [posttranslational modification]
866895011097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866895011098	ATP binding site [chemical binding]; other site
866895011099	Mg2+ binding site [ion binding]; other site
866895011100	G-X-G motif; other site
866895011101	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866895011102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895011103	active site
866895011104	phosphorylation site [posttranslational modification]
866895011105	intermolecular recognition site; other site
866895011106	dimerization interface [polypeptide binding]; other site
866895011107	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866895011108	DNA binding site [nucleotide binding]
866895011109	G5 domain; Region: G5; pfam07501
866895011110	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
866895011111	Peptidase family M23; Region: Peptidase_M23; pfam01551
866895011112	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
866895011113	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
866895011114	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
866895011115	GDP-binding site [chemical binding]; other site
866895011116	ACT binding site; other site
866895011117	IMP binding site; other site
866895011118	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866895011119	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
866895011120	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866895011121	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866895011122	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866895011123	active site
866895011124	motif I; other site
866895011125	motif II; other site
866895011126	replicative DNA helicase; Provisional; Region: PRK05748
866895011127	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
866895011128	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
866895011129	Walker A motif; other site
866895011130	ATP binding site [chemical binding]; other site
866895011131	Walker B motif; other site
866895011132	DNA binding loops [nucleotide binding]
866895011133	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
866895011134	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
866895011135	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
866895011136	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
866895011137	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
866895011138	DHH family; Region: DHH; pfam01368
866895011139	DHHA1 domain; Region: DHHA1; pfam02272
866895011140	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
866895011141	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
866895011142	histidinol-phosphatase; Provisional; Region: PRK07328
866895011143	active site
866895011144	dimer interface [polypeptide binding]; other site
866895011145	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
866895011146	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
866895011147	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
866895011148	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
866895011149	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
866895011150	ligand binding site [chemical binding]; other site
866895011151	NAD binding site [chemical binding]; other site
866895011152	dimerization interface [polypeptide binding]; other site
866895011153	catalytic site [active]
866895011154	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
866895011155	putative L-serine binding site [chemical binding]; other site
866895011156	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
866895011157	homodimer interface [polypeptide binding]; other site
866895011158	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866895011159	catalytic residue [active]
866895011160	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866895011161	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866895011162	peptide binding site [polypeptide binding]; other site
866895011163	Predicted membrane protein [Function unknown]; Region: COG2364
866895011164	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
866895011165	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
866895011166	heme-binding site [chemical binding]; other site
866895011167	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
866895011168	FAD binding pocket [chemical binding]; other site
866895011169	FAD binding motif [chemical binding]; other site
866895011170	phosphate binding motif [ion binding]; other site
866895011171	beta-alpha-beta structure motif; other site
866895011172	NAD binding pocket [chemical binding]; other site
866895011173	Predicted transcriptional regulator [Transcription]; Region: COG1959
866895011174	Transcriptional regulator; Region: Rrf2; cl17282
866895011175	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
866895011176	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
866895011177	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
866895011178	dimer interface [polypeptide binding]; other site
866895011179	ssDNA binding site [nucleotide binding]; other site
866895011180	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866895011181	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
866895011182	GTP-binding protein YchF; Reviewed; Region: PRK09601
866895011183	YchF GTPase; Region: YchF; cd01900
866895011184	G1 box; other site
866895011185	GTP/Mg2+ binding site [chemical binding]; other site
866895011186	Switch I region; other site
866895011187	G2 box; other site
866895011188	Switch II region; other site
866895011189	G3 box; other site
866895011190	G4 box; other site
866895011191	G5 box; other site
866895011192	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
866895011193	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
866895011194	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866895011195	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866895011196	Uncharacterized membrane protein [Function unknown]; Region: COG3949
866895011197	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
866895011198	Protein of unknown function (DUF554); Region: DUF554; pfam04474
866895011199	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
866895011200	ParB-like nuclease domain; Region: ParBc; pfam02195
866895011201	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
866895011202	ParB-like nuclease domain; Region: ParBc; pfam02195
866895011203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866895011204	putative substrate translocation pore; other site
866895011205	Major Facilitator Superfamily; Region: MFS_1; pfam07690
866895011206	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
866895011207	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
866895011208	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
866895011209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866895011210	active site
866895011211	phosphorylation site [posttranslational modification]
866895011212	intermolecular recognition site; other site
866895011213	dimerization interface [polypeptide binding]; other site
866895011214	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
866895011215	DNA binding residues [nucleotide binding]
866895011216	dimerization interface [polypeptide binding]; other site
866895011217	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
866895011218	Histidine kinase; Region: HisKA_3; pfam07730
866895011219	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
866895011220	Mg2+ binding site [ion binding]; other site
866895011221	G-X-G motif; other site
866895011222	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
866895011223	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866895011224	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866895011225	Walker A/P-loop; other site
866895011226	ATP binding site [chemical binding]; other site
866895011227	Q-loop/lid; other site
866895011228	ABC transporter signature motif; other site
866895011229	Walker B; other site
866895011230	D-loop; other site
866895011231	H-loop/switch region; other site
866895011232	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866895011233	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866895011234	Transcriptional regulator protein (SplA); Region: SplA; pfam11132
866895011235	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
866895011236	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
866895011237	FeS/SAM binding site; other site
866895011238	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
866895011239	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
866895011240	NAD binding site [chemical binding]; other site
866895011241	metal binding site [ion binding]; metal-binding site
866895011242	active site
866895011243	endonuclease VIII; Provisional; Region: PRK10445
866895011244	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
866895011245	DNA binding site [nucleotide binding]
866895011246	catalytic residue [active]
866895011247	putative catalytic residues [active]
866895011248	H2TH interface [polypeptide binding]; other site
866895011249	intercalation triad [nucleotide binding]; other site
866895011250	substrate specificity determining residue; other site
866895011251	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
866895011252	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
866895011253	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866895011254	active site
866895011255	metal binding site [ion binding]; metal-binding site
866895011256	homotetramer interface [polypeptide binding]; other site
866895011257	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
866895011258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866895011259	S-adenosylmethionine binding site [chemical binding]; other site
866895011260	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
866895011261	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
866895011262	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
866895011263	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
866895011264	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
866895011265	trmE is a tRNA modification GTPase; Region: trmE; cd04164
866895011266	G1 box; other site
866895011267	GTP/Mg2+ binding site [chemical binding]; other site
866895011268	Switch I region; other site
866895011269	G2 box; other site
866895011270	Switch II region; other site
866895011271	G3 box; other site
866895011272	G4 box; other site
866895011273	G5 box; other site
866895011274	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
866895011275	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
866895011276	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
866895011277	G-X-X-G motif; other site
866895011278	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
866895011279	RxxxH motif; other site
866895011280	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
866895011281	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
866895011282	ribonuclease P; Reviewed; Region: rnpA; PRK00499
866895011283	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
866895011284	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866895011285	active site
866895011286	DNA binding site [nucleotide binding]
866895011287	Int/Topo IB signature motif; other site
866895011288	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
866895011289	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
866895011290	CHAT domain; Region: CHAT; cl17868
866895011291	Homeodomain-like domain; Region: HTH_23; cl17451
866895011292	Helix-turn-helix domain; Region: HTH_36; pfam13730
866895011293	Replication protein; Region: Rep_1; pfam01446
866895011294	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
866895011295	DNA binding residues [nucleotide binding]