-- dump date 20140619_110922 -- class Genbank::misc_feature -- table misc_feature_note -- id note 748449000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 748449000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 748449000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449000004 Walker A motif; other site 748449000005 ATP binding site [chemical binding]; other site 748449000006 Walker B motif; other site 748449000007 arginine finger; other site 748449000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 748449000009 DnaA box-binding interface [nucleotide binding]; other site 748449000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 748449000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 748449000012 putative DNA binding surface [nucleotide binding]; other site 748449000013 dimer interface [polypeptide binding]; other site 748449000014 beta-clamp/clamp loader binding surface; other site 748449000015 beta-clamp/translesion DNA polymerase binding surface; other site 748449000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748449000017 RNA binding surface [nucleotide binding]; other site 748449000018 recombination protein F; Reviewed; Region: recF; PRK00064 748449000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449000020 Walker A/P-loop; other site 748449000021 ATP binding site [chemical binding]; other site 748449000022 Q-loop/lid; other site 748449000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449000024 ABC transporter signature motif; other site 748449000025 Walker B; other site 748449000026 D-loop; other site 748449000027 H-loop/switch region; other site 748449000028 Protein of unknown function (DUF721); Region: DUF721; pfam05258 748449000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 748449000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449000031 Mg2+ binding site [ion binding]; other site 748449000032 G-X-G motif; other site 748449000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 748449000034 anchoring element; other site 748449000035 dimer interface [polypeptide binding]; other site 748449000036 ATP binding site [chemical binding]; other site 748449000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 748449000038 active site 748449000039 putative metal-binding site [ion binding]; other site 748449000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 748449000041 DNA gyrase subunit A; Validated; Region: PRK05560 748449000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 748449000043 CAP-like domain; other site 748449000044 active site 748449000045 primary dimer interface [polypeptide binding]; other site 748449000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748449000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748449000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748449000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748449000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748449000051 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 748449000052 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 748449000053 ligand binding site [chemical binding]; other site 748449000054 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748449000055 Spore germination protein; Region: Spore_permease; cl17796 748449000056 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748449000057 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748449000058 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 748449000059 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 748449000060 oligomer interface [polypeptide binding]; other site 748449000061 tandem repeat interface [polypeptide binding]; other site 748449000062 active site residues [active] 748449000063 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 748449000064 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 748449000065 homodimer interface [polypeptide binding]; other site 748449000066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449000067 catalytic residue [active] 748449000068 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 748449000069 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 748449000070 ligand binding site [chemical binding]; other site 748449000071 NAD binding site [chemical binding]; other site 748449000072 dimerization interface [polypeptide binding]; other site 748449000073 catalytic site [active] 748449000074 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 748449000075 putative L-serine binding site [chemical binding]; other site 748449000076 seryl-tRNA synthetase; Provisional; Region: PRK05431 748449000077 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 748449000078 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 748449000079 dimer interface [polypeptide binding]; other site 748449000080 active site 748449000081 motif 1; other site 748449000082 motif 2; other site 748449000083 motif 3; other site 748449000084 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 748449000085 beta-galactosidase; Region: BGL; TIGR03356 748449000086 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 748449000087 dimer interface [polypeptide binding]; other site 748449000088 [2Fe-2S] cluster binding site [ion binding]; other site 748449000089 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 748449000090 4Fe-4S binding domain; Region: Fer4; pfam00037 748449000091 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748449000092 PAS domain; Region: PAS; smart00091 748449000093 PAS domain; Region: PAS_9; pfam13426 748449000094 putative active site [active] 748449000095 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 748449000096 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 748449000097 putative dimer interface [polypeptide binding]; other site 748449000098 [2Fe-2S] cluster binding site [ion binding]; other site 748449000099 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 748449000100 4Fe-4S binding domain; Region: Fer4; pfam00037 748449000101 4Fe-4S binding domain; Region: Fer4; pfam00037 748449000102 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748449000103 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 748449000104 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 748449000105 CoA binding domain; Region: CoA_binding; pfam02629 748449000106 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 748449000107 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 748449000108 putative catalytic cysteine [active] 748449000109 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 748449000110 putative active site [active] 748449000111 metal binding site [ion binding]; metal-binding site 748449000112 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 748449000113 Mg binding site [ion binding]; other site 748449000114 nucleotide binding site [chemical binding]; other site 748449000115 putative protofilament interface [polypeptide binding]; other site 748449000116 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 748449000117 nucleoside/Zn binding site; other site 748449000118 dimer interface [polypeptide binding]; other site 748449000119 catalytic motif [active] 748449000120 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 748449000121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449000122 Walker A motif; other site 748449000123 ATP binding site [chemical binding]; other site 748449000124 Walker B motif; other site 748449000125 arginine finger; other site 748449000126 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 748449000127 hypothetical protein; Validated; Region: PRK00153 748449000128 recombination protein RecR; Reviewed; Region: recR; PRK00076 748449000129 RecR protein; Region: RecR; pfam02132 748449000130 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 748449000131 putative active site [active] 748449000132 putative metal-binding site [ion binding]; other site 748449000133 tetramer interface [polypeptide binding]; other site 748449000134 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 748449000135 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 748449000136 dimer interface [polypeptide binding]; other site 748449000137 PYR/PP interface [polypeptide binding]; other site 748449000138 TPP binding site [chemical binding]; other site 748449000139 substrate binding site [chemical binding]; other site 748449000140 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 748449000141 Domain of unknown function; Region: EKR; smart00890 748449000142 4Fe-4S binding domain; Region: Fer4_6; pfam12837 748449000143 4Fe-4S binding domain; Region: Fer4; pfam00037 748449000144 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 748449000145 TPP-binding site [chemical binding]; other site 748449000146 dimer interface [polypeptide binding]; other site 748449000147 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 748449000148 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 748449000149 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 748449000150 4Fe-4S binding domain; Region: Fer4; pfam00037 748449000151 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 748449000152 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 748449000153 dimer interface [polypeptide binding]; other site 748449000154 PYR/PP interface [polypeptide binding]; other site 748449000155 TPP binding site [chemical binding]; other site 748449000156 substrate binding site [chemical binding]; other site 748449000157 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 748449000158 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 748449000159 TPP-binding site [chemical binding]; other site 748449000160 putative dimer interface [polypeptide binding]; other site 748449000161 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449000162 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449000163 putative active site [active] 748449000164 putative NTP binding site [chemical binding]; other site 748449000165 putative nucleic acid binding site [nucleotide binding]; other site 748449000166 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449000167 YibE/F-like protein; Region: YibE_F; pfam07907 748449000168 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 748449000169 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 748449000170 dimer interface [polypeptide binding]; other site 748449000171 active site 748449000172 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 748449000173 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 748449000174 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 748449000175 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 748449000176 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 748449000177 active site 748449000178 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 748449000179 thymidylate kinase; Provisional; Region: PRK13975; cl17243 748449000180 Protein of unknown function (DUF327); Region: DUF327; pfam03885 748449000181 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 748449000182 DNA polymerase III subunit delta'; Validated; Region: PRK08485 748449000183 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 748449000184 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 748449000185 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 748449000186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449000187 S-adenosylmethionine binding site [chemical binding]; other site 748449000188 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 748449000189 GIY-YIG motif/motif A; other site 748449000190 putative active site [active] 748449000191 putative metal binding site [ion binding]; other site 748449000192 Predicted methyltransferases [General function prediction only]; Region: COG0313 748449000193 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 748449000194 putative SAM binding site [chemical binding]; other site 748449000195 putative homodimer interface [polypeptide binding]; other site 748449000196 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 748449000197 NurA domain; Region: NurA; pfam09376 748449000198 RRXRR protein; Region: RRXRR; pfam14239 748449000199 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 748449000200 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 748449000201 active site 748449000202 HerA helicase [Replication, recombination, and repair]; Region: COG0433 748449000203 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748449000204 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 748449000205 dimerization interface [polypeptide binding]; other site 748449000206 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449000207 dimer interface [polypeptide binding]; other site 748449000208 putative CheW interface [polypeptide binding]; other site 748449000209 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 748449000210 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 748449000211 active site 748449000212 HIGH motif; other site 748449000213 KMSKS motif; other site 748449000214 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 748449000215 tRNA binding surface [nucleotide binding]; other site 748449000216 anticodon binding site; other site 748449000217 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 748449000218 dimer interface [polypeptide binding]; other site 748449000219 putative tRNA-binding site [nucleotide binding]; other site 748449000220 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 748449000221 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 748449000222 active site 748449000223 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 748449000224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449000225 FeS/SAM binding site; other site 748449000226 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449000227 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748449000228 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 748449000229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449000230 dimer interface [polypeptide binding]; other site 748449000231 conserved gate region; other site 748449000232 putative PBP binding loops; other site 748449000233 ABC-ATPase subunit interface; other site 748449000234 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449000235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449000236 dimer interface [polypeptide binding]; other site 748449000237 conserved gate region; other site 748449000238 putative PBP binding loops; other site 748449000239 ABC-ATPase subunit interface; other site 748449000240 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449000241 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449000242 DNA binding site [nucleotide binding] 748449000243 domain linker motif; other site 748449000244 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 748449000245 putative dimerization interface [polypeptide binding]; other site 748449000246 putative ligand binding site [chemical binding]; other site 748449000247 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 748449000248 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 748449000249 putative active site [active] 748449000250 putative metal binding site [ion binding]; other site 748449000251 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 748449000252 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 748449000253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449000254 S-adenosylmethionine binding site [chemical binding]; other site 748449000255 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 748449000256 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449000257 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449000258 putative active site [active] 748449000259 putative NTP binding site [chemical binding]; other site 748449000260 putative nucleic acid binding site [nucleotide binding]; other site 748449000261 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449000262 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449000263 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449000264 putative active site [active] 748449000265 putative NTP binding site [chemical binding]; other site 748449000266 putative nucleic acid binding site [nucleotide binding]; other site 748449000267 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449000268 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 748449000269 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 748449000270 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 748449000271 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 748449000272 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 748449000273 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449000274 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 748449000275 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748449000276 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 748449000277 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 748449000278 proposed catalytic triad [active] 748449000279 active site nucleophile [active] 748449000280 cyanophycin synthetase; Provisional; Region: PRK14016 748449000281 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748449000282 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748449000283 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748449000284 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 748449000285 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 748449000286 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 748449000287 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 748449000288 active site 748449000289 pur operon repressor; Provisional; Region: PRK09213 748449000290 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 748449000291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748449000292 active site 748449000293 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 748449000294 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748449000295 DNA binding residues [nucleotide binding] 748449000296 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 748449000297 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 748449000298 active site 748449000299 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748449000300 putative substrate binding pocket [chemical binding]; other site 748449000301 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 748449000302 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 748449000303 Substrate binding site; other site 748449000304 Mg++ binding site; other site 748449000305 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 748449000306 active site 748449000307 substrate binding site [chemical binding]; other site 748449000308 CoA binding site [chemical binding]; other site 748449000309 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 748449000310 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 748449000311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748449000312 active site 748449000313 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 748449000314 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 748449000315 5S rRNA interface [nucleotide binding]; other site 748449000316 CTC domain interface [polypeptide binding]; other site 748449000317 L16 interface [polypeptide binding]; other site 748449000318 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 748449000319 putative active site [active] 748449000320 catalytic residue [active] 748449000321 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 748449000322 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 748449000323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449000324 ATP binding site [chemical binding]; other site 748449000325 putative Mg++ binding site [ion binding]; other site 748449000326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449000327 nucleotide binding region [chemical binding]; other site 748449000328 ATP-binding site [chemical binding]; other site 748449000329 TRCF domain; Region: TRCF; pfam03461 748449000330 stage V sporulation protein T; Region: spore_V_T; TIGR02851 748449000331 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 748449000332 GAF domain; Region: GAF; cl17456 748449000333 stage V sporulation protein B; Region: spore_V_B; TIGR02900 748449000334 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 748449000335 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 748449000336 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 748449000337 putative SAM binding site [chemical binding]; other site 748449000338 putative homodimer interface [polypeptide binding]; other site 748449000339 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 748449000340 homodimer interface [polypeptide binding]; other site 748449000341 metal binding site [ion binding]; metal-binding site 748449000342 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 748449000343 homodimer interface [polypeptide binding]; other site 748449000344 active site 748449000345 putative chemical substrate binding site [chemical binding]; other site 748449000346 metal binding site [ion binding]; metal-binding site 748449000347 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 748449000348 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748449000349 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 748449000350 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 748449000351 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 748449000352 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 748449000353 active site 748449000354 substrate binding site [chemical binding]; other site 748449000355 metal binding site [ion binding]; metal-binding site 748449000356 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449000357 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748449000358 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 748449000359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449000360 dimer interface [polypeptide binding]; other site 748449000361 conserved gate region; other site 748449000362 putative PBP binding loops; other site 748449000363 ABC-ATPase subunit interface; other site 748449000364 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449000366 dimer interface [polypeptide binding]; other site 748449000367 conserved gate region; other site 748449000368 putative PBP binding loops; other site 748449000369 ABC-ATPase subunit interface; other site 748449000370 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 748449000371 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 748449000372 Ca binding site [ion binding]; other site 748449000373 active site 748449000374 catalytic site [active] 748449000375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449000376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449000377 DNA binding site [nucleotide binding] 748449000378 domain linker motif; other site 748449000379 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449000380 ligand binding site [chemical binding]; other site 748449000381 dimerization interface [polypeptide binding]; other site 748449000382 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 748449000383 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 748449000384 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 748449000385 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 748449000386 UV-endonuclease UvdE; Region: UvdE; cl10036 748449000387 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 748449000388 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 748449000389 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 748449000390 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 748449000391 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449000392 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449000393 DNA binding site [nucleotide binding] 748449000394 domain linker motif; other site 748449000395 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449000396 dimerization interface [polypeptide binding]; other site 748449000397 ligand binding site [chemical binding]; other site 748449000398 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 748449000399 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 748449000400 Walker A/P-loop; other site 748449000401 ATP binding site [chemical binding]; other site 748449000402 Q-loop/lid; other site 748449000403 ABC transporter signature motif; other site 748449000404 Walker B; other site 748449000405 D-loop; other site 748449000406 H-loop/switch region; other site 748449000407 TOBE domain; Region: TOBE_2; pfam08402 748449000408 YabP family; Region: YabP; cl06766 748449000409 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 748449000410 Septum formation initiator; Region: DivIC; pfam04977 748449000411 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 748449000412 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 748449000413 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 748449000414 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 748449000415 RNA binding site [nucleotide binding]; other site 748449000416 hypothetical protein; Provisional; Region: PRK08582 748449000417 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 748449000418 RNA binding site [nucleotide binding]; other site 748449000419 Protein of unknown function (DUF501); Region: DUF501; pfam04417 748449000420 exopolyphosphatase; Region: exo_poly_only; TIGR03706 748449000421 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 748449000422 stage II sporulation protein E; Region: spore_II_E; TIGR02865 748449000423 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 748449000424 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 748449000425 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 748449000426 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 748449000427 Ligand Binding Site [chemical binding]; other site 748449000428 TilS substrate binding domain; Region: TilS; pfam09179 748449000429 TilS substrate C-terminal domain; Region: TilS_C; smart00977 748449000430 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748449000431 active site 748449000432 FtsH Extracellular; Region: FtsH_ext; pfam06480 748449000433 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 748449000434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449000435 Walker A motif; other site 748449000436 ATP binding site [chemical binding]; other site 748449000437 Walker B motif; other site 748449000438 arginine finger; other site 748449000439 Peptidase family M41; Region: Peptidase_M41; pfam01434 748449000440 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 748449000441 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 748449000442 Potassium binding sites [ion binding]; other site 748449000443 Cesium cation binding sites [ion binding]; other site 748449000444 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 748449000445 oligomerization interface [polypeptide binding]; other site 748449000446 active site 748449000447 metal binding site [ion binding]; metal-binding site 748449000448 pantoate--beta-alanine ligase; Region: panC; TIGR00018 748449000449 Pantoate-beta-alanine ligase; Region: PanC; cd00560 748449000450 active site 748449000451 ATP-binding site [chemical binding]; other site 748449000452 pantoate-binding site; other site 748449000453 HXXH motif; other site 748449000454 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 748449000455 tetramerization interface [polypeptide binding]; other site 748449000456 active site 748449000457 Predicted membrane protein [Function unknown]; Region: COG4684 748449000458 Biotin operon repressor [Transcription]; Region: BirA; COG1654 748449000459 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 748449000460 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 748449000461 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 748449000462 pantothenate kinase; Reviewed; Region: PRK13318 748449000463 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 748449000464 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 748449000465 FMN binding site [chemical binding]; other site 748449000466 active site 748449000467 catalytic residues [active] 748449000468 substrate binding site [chemical binding]; other site 748449000469 Predicted dehydrogenase [General function prediction only]; Region: COG5322 748449000470 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 748449000471 NAD(P) binding pocket [chemical binding]; other site 748449000472 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 748449000473 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 748449000474 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 748449000475 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 748449000476 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 748449000477 dimer interface [polypeptide binding]; other site 748449000478 putative anticodon binding site; other site 748449000479 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 748449000480 motif 1; other site 748449000481 active site 748449000482 motif 2; other site 748449000483 motif 3; other site 748449000484 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 748449000485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449000486 S-adenosylmethionine binding site [chemical binding]; other site 748449000487 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 748449000488 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 748449000489 UvrB/uvrC motif; Region: UVR; pfam02151 748449000490 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 748449000491 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 748449000492 ADP binding site [chemical binding]; other site 748449000493 phosphagen binding site; other site 748449000494 substrate specificity loop; other site 748449000495 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 748449000496 Clp amino terminal domain; Region: Clp_N; pfam02861 748449000497 Clp amino terminal domain; Region: Clp_N; pfam02861 748449000498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449000499 Walker A motif; other site 748449000500 ATP binding site [chemical binding]; other site 748449000501 Walker B motif; other site 748449000502 arginine finger; other site 748449000503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449000504 Walker A motif; other site 748449000505 ATP binding site [chemical binding]; other site 748449000506 Walker B motif; other site 748449000507 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 748449000508 DNA repair protein RadA; Provisional; Region: PRK11823 748449000509 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 748449000510 Walker A motif/ATP binding site; other site 748449000511 ATP binding site [chemical binding]; other site 748449000512 Walker B motif; other site 748449000513 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 748449000514 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 748449000515 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 748449000516 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 748449000517 Helix-hairpin-helix motif; Region: HHH; pfam00633 748449000518 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 748449000519 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 748449000520 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 748449000521 putative active site [active] 748449000522 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 748449000523 substrate binding site; other site 748449000524 dimer interface; other site 748449000525 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 748449000526 homotrimer interaction site [polypeptide binding]; other site 748449000527 zinc binding site [ion binding]; other site 748449000528 CDP-binding sites; other site 748449000529 FOG: CBS domain [General function prediction only]; Region: COG0517 748449000530 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 748449000531 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 748449000532 hexamer interface [polypeptide binding]; other site 748449000533 RNA binding site [nucleotide binding]; other site 748449000534 Histidine-zinc binding site [chemical binding]; other site 748449000535 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 748449000536 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 748449000537 HIGH motif; other site 748449000538 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 748449000539 active site 748449000540 KMSKS motif; other site 748449000541 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 748449000542 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 748449000543 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 748449000544 trimer interface [polypeptide binding]; other site 748449000545 active site 748449000546 substrate binding site [chemical binding]; other site 748449000547 CoA binding site [chemical binding]; other site 748449000548 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 748449000549 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 748449000550 active site 748449000551 HIGH motif; other site 748449000552 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 748449000553 KMSKS motif; other site 748449000554 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 748449000555 tRNA binding surface [nucleotide binding]; other site 748449000556 anticodon binding site; other site 748449000557 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 748449000558 active site 748449000559 metal binding site [ion binding]; metal-binding site 748449000560 dimerization interface [polypeptide binding]; other site 748449000561 Thymidylate synthase complementing protein; Region: Thy1; cl03630 748449000562 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449000563 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449000564 putative active site [active] 748449000565 putative NTP binding site [chemical binding]; other site 748449000566 putative nucleic acid binding site [nucleotide binding]; other site 748449000567 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 748449000568 active site 748449000569 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 748449000570 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 748449000571 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 748449000572 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 748449000573 VanW like protein; Region: VanW; pfam04294 748449000574 G5 domain; Region: G5; pfam07501 748449000575 RNA polymerase factor sigma-70; Validated; Region: PRK08295 748449000576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449000577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 748449000578 DNA binding residues [nucleotide binding] 748449000579 elongation factor Tu; Reviewed; Region: PRK00049 748449000580 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 748449000581 G1 box; other site 748449000582 GEF interaction site [polypeptide binding]; other site 748449000583 GTP/Mg2+ binding site [chemical binding]; other site 748449000584 Switch I region; other site 748449000585 G2 box; other site 748449000586 G3 box; other site 748449000587 Switch II region; other site 748449000588 G4 box; other site 748449000589 G5 box; other site 748449000590 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 748449000591 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 748449000592 Antibiotic Binding Site [chemical binding]; other site 748449000593 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 748449000594 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 748449000595 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 748449000596 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 748449000597 putative homodimer interface [polypeptide binding]; other site 748449000598 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 748449000599 heterodimer interface [polypeptide binding]; other site 748449000600 homodimer interface [polypeptide binding]; other site 748449000601 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 748449000602 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 748449000603 23S rRNA interface [nucleotide binding]; other site 748449000604 L7/L12 interface [polypeptide binding]; other site 748449000605 putative thiostrepton binding site; other site 748449000606 L25 interface [polypeptide binding]; other site 748449000607 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 748449000608 mRNA/rRNA interface [nucleotide binding]; other site 748449000609 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 748449000610 23S rRNA interface [nucleotide binding]; other site 748449000611 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 748449000612 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 748449000613 L11 interface [polypeptide binding]; other site 748449000614 putative EF-Tu interaction site [polypeptide binding]; other site 748449000615 putative EF-G interaction site [polypeptide binding]; other site 748449000616 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 748449000617 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 748449000618 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 748449000619 RPB10 interaction site [polypeptide binding]; other site 748449000620 RPB1 interaction site [polypeptide binding]; other site 748449000621 RPB11 interaction site [polypeptide binding]; other site 748449000622 RPB3 interaction site [polypeptide binding]; other site 748449000623 RPB12 interaction site [polypeptide binding]; other site 748449000624 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 748449000625 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 748449000626 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 748449000627 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 748449000628 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 748449000629 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 748449000630 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 748449000631 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 748449000632 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 748449000633 DNA binding site [nucleotide binding] 748449000634 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 748449000635 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 748449000636 S17 interaction site [polypeptide binding]; other site 748449000637 S8 interaction site; other site 748449000638 16S rRNA interaction site [nucleotide binding]; other site 748449000639 streptomycin interaction site [chemical binding]; other site 748449000640 23S rRNA interaction site [nucleotide binding]; other site 748449000641 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 748449000642 30S ribosomal protein S7; Validated; Region: PRK05302 748449000643 elongation factor G; Reviewed; Region: PRK00007 748449000644 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 748449000645 G1 box; other site 748449000646 putative GEF interaction site [polypeptide binding]; other site 748449000647 GTP/Mg2+ binding site [chemical binding]; other site 748449000648 Switch I region; other site 748449000649 G2 box; other site 748449000650 G3 box; other site 748449000651 Switch II region; other site 748449000652 G4 box; other site 748449000653 G5 box; other site 748449000654 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 748449000655 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 748449000656 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 748449000657 elongation factor Tu; Reviewed; Region: PRK00049 748449000658 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 748449000659 G1 box; other site 748449000660 GEF interaction site [polypeptide binding]; other site 748449000661 GTP/Mg2+ binding site [chemical binding]; other site 748449000662 Switch I region; other site 748449000663 G2 box; other site 748449000664 G3 box; other site 748449000665 Switch II region; other site 748449000666 G4 box; other site 748449000667 G5 box; other site 748449000668 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 748449000669 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 748449000670 Antibiotic Binding Site [chemical binding]; other site 748449000671 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 748449000672 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 748449000673 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 748449000674 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 748449000675 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 748449000676 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 748449000677 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 748449000678 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 748449000679 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 748449000680 putative translocon binding site; other site 748449000681 protein-rRNA interface [nucleotide binding]; other site 748449000682 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 748449000683 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 748449000684 G-X-X-G motif; other site 748449000685 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 748449000686 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 748449000687 23S rRNA interface [nucleotide binding]; other site 748449000688 5S rRNA interface [nucleotide binding]; other site 748449000689 putative antibiotic binding site [chemical binding]; other site 748449000690 L25 interface [polypeptide binding]; other site 748449000691 L27 interface [polypeptide binding]; other site 748449000692 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 748449000693 23S rRNA interface [nucleotide binding]; other site 748449000694 putative translocon interaction site; other site 748449000695 signal recognition particle (SRP54) interaction site; other site 748449000696 L23 interface [polypeptide binding]; other site 748449000697 trigger factor interaction site; other site 748449000698 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 748449000699 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 748449000700 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 748449000701 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 748449000702 RNA binding site [nucleotide binding]; other site 748449000703 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 748449000704 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 748449000705 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 748449000706 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 748449000707 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 748449000708 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 748449000709 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 748449000710 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 748449000711 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 748449000712 5S rRNA interface [nucleotide binding]; other site 748449000713 23S rRNA interface [nucleotide binding]; other site 748449000714 L5 interface [polypeptide binding]; other site 748449000715 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 748449000716 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 748449000717 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 748449000718 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 748449000719 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 748449000720 SecY translocase; Region: SecY; pfam00344 748449000721 adenylate kinase; Reviewed; Region: adk; PRK00279 748449000722 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 748449000723 AMP-binding site [chemical binding]; other site 748449000724 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 748449000725 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 748449000726 active site 748449000727 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 748449000728 rRNA binding site [nucleotide binding]; other site 748449000729 predicted 30S ribosome binding site; other site 748449000730 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 748449000731 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 748449000732 30S ribosomal protein S13; Region: bact_S13; TIGR03631 748449000733 30S ribosomal protein S11; Validated; Region: PRK05309 748449000734 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 748449000735 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 748449000736 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748449000737 RNA binding surface [nucleotide binding]; other site 748449000738 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 748449000739 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 748449000740 alphaNTD homodimer interface [polypeptide binding]; other site 748449000741 alphaNTD - beta interaction site [polypeptide binding]; other site 748449000742 alphaNTD - beta' interaction site [polypeptide binding]; other site 748449000743 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 748449000744 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 748449000745 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 748449000746 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748449000747 Walker A/P-loop; other site 748449000748 ATP binding site [chemical binding]; other site 748449000749 Q-loop/lid; other site 748449000750 ABC transporter signature motif; other site 748449000751 Walker B; other site 748449000752 D-loop; other site 748449000753 H-loop/switch region; other site 748449000754 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 748449000755 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748449000756 Walker A/P-loop; other site 748449000757 ATP binding site [chemical binding]; other site 748449000758 Q-loop/lid; other site 748449000759 ABC transporter signature motif; other site 748449000760 Walker B; other site 748449000761 D-loop; other site 748449000762 H-loop/switch region; other site 748449000763 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 748449000764 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 748449000765 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 748449000766 dimerization interface 3.5A [polypeptide binding]; other site 748449000767 active site 748449000768 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 748449000769 23S rRNA interface [nucleotide binding]; other site 748449000770 L3 interface [polypeptide binding]; other site 748449000771 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 748449000772 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 748449000773 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 748449000774 active site 748449000775 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748449000776 dimer interface [polypeptide binding]; other site 748449000777 substrate binding site [chemical binding]; other site 748449000778 catalytic residue [active] 748449000779 agmatinase; Region: agmatinase; TIGR01230 748449000780 Arginase family; Region: Arginase; cd09989 748449000781 active site 748449000782 Mn binding site [ion binding]; other site 748449000783 oligomer interface [polypeptide binding]; other site 748449000784 hypothetical protein; Provisional; Region: PRK03881 748449000785 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 748449000786 AMMECR1; Region: AMMECR1; pfam01871 748449000787 CAAX protease self-immunity; Region: Abi; pfam02517 748449000788 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 748449000789 6-phosphogluconate dehydratase; Region: edd; TIGR01196 748449000790 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449000791 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449000792 DNA binding site [nucleotide binding] 748449000793 domain linker motif; other site 748449000794 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449000795 dimerization interface [polypeptide binding]; other site 748449000796 ligand binding site [chemical binding]; other site 748449000797 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 748449000798 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748449000799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449000800 dimer interface [polypeptide binding]; other site 748449000801 conserved gate region; other site 748449000802 putative PBP binding loops; other site 748449000803 ABC-ATPase subunit interface; other site 748449000804 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449000805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449000806 dimer interface [polypeptide binding]; other site 748449000807 conserved gate region; other site 748449000808 putative PBP binding loops; other site 748449000809 ABC-ATPase subunit interface; other site 748449000810 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 748449000811 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 748449000812 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 748449000813 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 748449000814 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 748449000815 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 748449000816 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 748449000817 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 748449000818 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751 748449000819 Protein of unknown function, DUF608; Region: DUF608; pfam04685 748449000820 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748449000821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449000822 S-adenosylmethionine binding site [chemical binding]; other site 748449000823 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 748449000824 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 748449000825 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 748449000826 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 748449000827 AMP binding site [chemical binding]; other site 748449000828 active site 748449000829 acyl-activating enzyme (AAE) consensus motif; other site 748449000830 acyl-activating enzyme (AAE) consensus motif; other site 748449000831 CoA binding site [chemical binding]; other site 748449000832 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 748449000833 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 748449000834 dimer interface [polypeptide binding]; other site 748449000835 active site 748449000836 BioY family; Region: BioY; pfam02632 748449000837 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 748449000838 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 748449000839 PYR/PP interface [polypeptide binding]; other site 748449000840 dimer interface [polypeptide binding]; other site 748449000841 TPP binding site [chemical binding]; other site 748449000842 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 748449000843 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 748449000844 TPP-binding site [chemical binding]; other site 748449000845 dimer interface [polypeptide binding]; other site 748449000846 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 748449000847 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 748449000848 putative valine binding site [chemical binding]; other site 748449000849 dimer interface [polypeptide binding]; other site 748449000850 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 748449000851 ketol-acid reductoisomerase; Provisional; Region: PRK05479 748449000852 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 748449000853 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 748449000854 2-isopropylmalate synthase; Validated; Region: PRK00915 748449000855 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 748449000856 active site 748449000857 catalytic residues [active] 748449000858 metal binding site [ion binding]; metal-binding site 748449000859 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 748449000860 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 748449000861 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 748449000862 substrate binding site [chemical binding]; other site 748449000863 ligand binding site [chemical binding]; other site 748449000864 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 748449000865 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 748449000866 substrate binding site [chemical binding]; other site 748449000867 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 748449000868 tartrate dehydrogenase; Region: TTC; TIGR02089 748449000869 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 748449000870 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 748449000871 active site 748449000872 catalytic residues [active] 748449000873 metal binding site [ion binding]; metal-binding site 748449000874 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 748449000875 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748449000876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748449000877 DNA-binding site [nucleotide binding]; DNA binding site 748449000878 UTRA domain; Region: UTRA; pfam07702 748449000879 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 748449000880 active site 748449000881 P-loop; other site 748449000882 phosphorylation site [posttranslational modification] 748449000883 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748449000884 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 748449000885 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449000886 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748449000887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449000888 dimer interface [polypeptide binding]; other site 748449000889 conserved gate region; other site 748449000890 putative PBP binding loops; other site 748449000891 ABC-ATPase subunit interface; other site 748449000892 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449000893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449000894 dimer interface [polypeptide binding]; other site 748449000895 conserved gate region; other site 748449000896 putative PBP binding loops; other site 748449000897 ABC-ATPase subunit interface; other site 748449000898 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 748449000899 beta-galactosidase; Region: BGL; TIGR03356 748449000900 N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749 748449000901 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 748449000902 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748449000903 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748449000904 active site 748449000905 catalytic tetrad [active] 748449000906 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 748449000907 active site 748449000908 catalytic residues [active] 748449000909 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 748449000910 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 748449000911 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 748449000912 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 748449000913 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 748449000914 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 748449000915 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 748449000916 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 748449000917 active site 748449000918 catalytic residues [active] 748449000919 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 748449000920 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449000921 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449000922 dimer interface [polypeptide binding]; other site 748449000923 putative CheW interface [polypeptide binding]; other site 748449000924 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748449000925 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 748449000926 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 748449000927 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748449000928 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748449000929 active site 748449000930 catalytic tetrad [active] 748449000931 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 748449000932 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 748449000933 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 748449000934 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 748449000935 Uncharacterized conserved protein [Function unknown]; Region: COG1624 748449000936 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 748449000937 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 748449000938 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 748449000939 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 748449000940 active site 748449000941 P-loop; other site 748449000942 phosphorylation site [posttranslational modification] 748449000943 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 748449000944 HTH domain; Region: HTH_11; pfam08279 748449000945 PRD domain; Region: PRD; pfam00874 748449000946 PRD domain; Region: PRD; pfam00874 748449000947 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 748449000948 active site 748449000949 P-loop; other site 748449000950 phosphorylation site [posttranslational modification] 748449000951 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 748449000952 active site 748449000953 phosphorylation site [posttranslational modification] 748449000954 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748449000955 active site 748449000956 phosphorylation site [posttranslational modification] 748449000957 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 748449000958 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 748449000959 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 748449000960 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 748449000961 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 748449000962 active site 748449000963 substrate binding site [chemical binding]; other site 748449000964 metal binding site [ion binding]; metal-binding site 748449000965 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 748449000966 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 748449000967 glutaminase active site [active] 748449000968 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 748449000969 dimer interface [polypeptide binding]; other site 748449000970 active site 748449000971 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 748449000972 dimer interface [polypeptide binding]; other site 748449000973 active site 748449000974 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748449000975 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 748449000976 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 748449000977 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 748449000978 Uncharacterized conserved protein [Function unknown]; Region: COG0062 748449000979 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 748449000980 putative substrate binding site [chemical binding]; other site 748449000981 putative ATP binding site [chemical binding]; other site 748449000982 FOG: CBS domain [General function prediction only]; Region: COG0517 748449000983 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 748449000984 DbpA RNA binding domain; Region: DbpA; pfam03880 748449000985 DNA helicase, putative; Region: TIGR00376 748449000986 AAA domain; Region: AAA_30; pfam13604 748449000987 AAA domain; Region: AAA_12; pfam13087 748449000988 PemK-like protein; Region: PemK; pfam02452 748449000989 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 748449000990 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 748449000991 metal binding site [ion binding]; metal-binding site 748449000992 dimer interface [polypeptide binding]; other site 748449000993 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 748449000994 Tetratricopeptide repeat; Region: TPR_16; pfam13432 748449000995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449000996 binding surface 748449000997 TPR motif; other site 748449000998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449000999 binding surface 748449001000 TPR motif; other site 748449001001 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 748449001002 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 748449001003 Glycoprotease family; Region: Peptidase_M22; pfam00814 748449001004 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 748449001005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748449001006 Coenzyme A binding pocket [chemical binding]; other site 748449001007 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 748449001008 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 748449001009 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748449001010 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 748449001011 Na2 binding site [ion binding]; other site 748449001012 putative substrate binding site 1 [chemical binding]; other site 748449001013 Na binding site 1 [ion binding]; other site 748449001014 putative substrate binding site 2 [chemical binding]; other site 748449001015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449001016 Radical SAM superfamily; Region: Radical_SAM; pfam04055 748449001017 FeS/SAM binding site; other site 748449001018 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 748449001019 Protein of unknown function (DUF512); Region: DUF512; pfam04459 748449001020 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 748449001021 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 748449001022 NAD(P) binding site [chemical binding]; other site 748449001023 LDH/MDH dimer interface [polypeptide binding]; other site 748449001024 substrate binding site [chemical binding]; other site 748449001025 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 748449001026 hypothetical protein; Validated; Region: PRK00194 748449001027 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 748449001028 oligomerisation interface [polypeptide binding]; other site 748449001029 mobile loop; other site 748449001030 roof hairpin; other site 748449001031 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 748449001032 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 748449001033 ring oligomerisation interface [polypeptide binding]; other site 748449001034 ATP/Mg binding site [chemical binding]; other site 748449001035 stacking interactions; other site 748449001036 hinge regions; other site 748449001037 nickel responsive regulator; Provisional; Region: PRK04460 748449001038 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 748449001039 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 748449001040 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 748449001041 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 748449001042 Ligand Binding Site [chemical binding]; other site 748449001043 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 748449001044 AIR carboxylase; Region: AIRC; smart01001 748449001045 GMP synthase; Reviewed; Region: guaA; PRK00074 748449001046 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 748449001047 AMP/PPi binding site [chemical binding]; other site 748449001048 candidate oxyanion hole; other site 748449001049 catalytic triad [active] 748449001050 potential glutamine specificity residues [chemical binding]; other site 748449001051 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 748449001052 ATP Binding subdomain [chemical binding]; other site 748449001053 Ligand Binding sites [chemical binding]; other site 748449001054 Dimerization subdomain; other site 748449001055 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 748449001056 Sulfate transporter family; Region: Sulfate_transp; pfam00916 748449001057 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 748449001058 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 748449001059 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 748449001060 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 748449001061 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 748449001062 substrate binding site [chemical binding]; other site 748449001063 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 748449001064 substrate binding site [chemical binding]; other site 748449001065 ligand binding site [chemical binding]; other site 748449001066 Predicted permeases [General function prediction only]; Region: COG0679 748449001067 EamA-like transporter family; Region: EamA; pfam00892 748449001068 EamA-like transporter family; Region: EamA; cl17759 748449001069 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 748449001070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748449001071 putative substrate translocation pore; other site 748449001072 FOG: CBS domain [General function prediction only]; Region: COG0517 748449001073 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 748449001074 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449001075 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449001076 dimer interface [polypeptide binding]; other site 748449001077 putative CheW interface [polypeptide binding]; other site 748449001078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748449001079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748449001080 putative substrate translocation pore; other site 748449001081 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 748449001082 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 748449001083 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748449001084 catalytic residue [active] 748449001085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748449001086 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748449001087 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748449001088 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 748449001089 SEC-C motif; Region: SEC-C; pfam02810 748449001090 epoxyqueuosine reductase; Region: TIGR00276 748449001091 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 748449001092 4Fe-4S binding domain; Region: Fer4; cl02805 748449001093 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 748449001094 HEAT repeat; Region: HEAT; pfam02985 748449001095 biotin synthase; Region: bioB; TIGR00433 748449001096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449001097 FeS/SAM binding site; other site 748449001098 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 748449001099 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 748449001100 putative FMN binding site [chemical binding]; other site 748449001101 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 748449001102 active site 1 [active] 748449001103 dimer interface [polypeptide binding]; other site 748449001104 hexamer interface [polypeptide binding]; other site 748449001105 active site 2 [active] 748449001106 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 748449001107 Uncharacterized conserved protein [Function unknown]; Region: COG2006 748449001108 4Fe-4S binding domain; Region: Fer4; pfam00037 748449001109 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 748449001110 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748449001111 MarR family; Region: MarR; pfam01047 748449001112 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 748449001113 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 748449001114 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 748449001115 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 748449001116 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449001117 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449001118 putative active site [active] 748449001119 putative NTP binding site [chemical binding]; other site 748449001120 putative nucleic acid binding site [nucleotide binding]; other site 748449001121 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 748449001122 active site 748449001123 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748449001124 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 748449001125 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 748449001126 catalytic triad [active] 748449001127 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 748449001128 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 748449001129 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449001130 Zn2+ binding site [ion binding]; other site 748449001131 Mg2+ binding site [ion binding]; other site 748449001132 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 748449001133 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 748449001134 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 748449001135 E-class dimer interface [polypeptide binding]; other site 748449001136 P-class dimer interface [polypeptide binding]; other site 748449001137 active site 748449001138 Cu2+ binding site [ion binding]; other site 748449001139 Zn2+ binding site [ion binding]; other site 748449001140 Uncharacterized conserved protein [Function unknown]; Region: COG2006 748449001141 Domain of unknown function (DUF362); Region: DUF362; pfam04015 748449001142 Uncharacterized conserved protein [Function unknown]; Region: COG1683 748449001143 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 748449001144 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 748449001145 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 748449001146 homodimer interface [polypeptide binding]; other site 748449001147 substrate-cofactor binding pocket; other site 748449001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449001149 catalytic residue [active] 748449001150 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748449001151 catalytic residues [active] 748449001152 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 748449001153 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 748449001154 dimer interface [polypeptide binding]; other site 748449001155 NAD binding site [chemical binding]; other site 748449001156 substrate binding site [chemical binding]; other site 748449001157 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748449001158 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748449001159 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 748449001160 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748449001161 metal binding site 2 [ion binding]; metal-binding site 748449001162 putative DNA binding helix; other site 748449001163 metal binding site 1 [ion binding]; metal-binding site 748449001164 dimer interface [polypeptide binding]; other site 748449001165 structural Zn2+ binding site [ion binding]; other site 748449001166 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 748449001167 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 748449001168 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 748449001169 putative dimer interface [polypeptide binding]; other site 748449001170 [2Fe-2S] cluster binding site [ion binding]; other site 748449001171 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 748449001172 dimer interface [polypeptide binding]; other site 748449001173 [2Fe-2S] cluster binding site [ion binding]; other site 748449001174 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 748449001175 SLBB domain; Region: SLBB; pfam10531 748449001176 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 748449001177 4Fe-4S binding domain; Region: Fer4; pfam00037 748449001178 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748449001179 4Fe-4S binding domain; Region: Fer4; pfam00037 748449001180 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 748449001181 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748449001182 catalytic loop [active] 748449001183 iron binding site [ion binding]; other site 748449001184 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 748449001185 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 748449001186 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748449001187 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 748449001188 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 748449001189 histidinol-phosphatase; Provisional; Region: PRK07328 748449001190 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 748449001191 active site 748449001192 dimer interface [polypeptide binding]; other site 748449001193 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 748449001194 MgtE intracellular N domain; Region: MgtE_N; pfam03448 748449001195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 748449001196 Divalent cation transporter; Region: MgtE; pfam01769 748449001197 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 748449001198 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 748449001199 G1 box; other site 748449001200 putative GEF interaction site [polypeptide binding]; other site 748449001201 GTP/Mg2+ binding site [chemical binding]; other site 748449001202 Switch I region; other site 748449001203 G2 box; other site 748449001204 G3 box; other site 748449001205 Switch II region; other site 748449001206 G4 box; other site 748449001207 G5 box; other site 748449001208 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 748449001209 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 748449001210 aspartate aminotransferase; Provisional; Region: PRK05764 748449001211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748449001212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449001213 homodimer interface [polypeptide binding]; other site 748449001214 catalytic residue [active] 748449001215 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 748449001216 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 748449001217 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 748449001218 active site 748449001219 PHP Thumb interface [polypeptide binding]; other site 748449001220 metal binding site [ion binding]; metal-binding site 748449001221 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 748449001222 generic binding surface II; other site 748449001223 generic binding surface I; other site 748449001224 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 748449001225 tetramer interfaces [polypeptide binding]; other site 748449001226 binuclear metal-binding site [ion binding]; other site 748449001227 Domain of unknown function (DUF368); Region: DUF368; pfam04018 748449001228 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 748449001229 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 748449001230 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 748449001231 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 748449001232 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 748449001233 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 748449001234 glutamine binding [chemical binding]; other site 748449001235 catalytic triad [active] 748449001236 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 748449001237 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 748449001238 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 748449001239 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 748449001240 active site 748449001241 ribulose/triose binding site [chemical binding]; other site 748449001242 phosphate binding site [ion binding]; other site 748449001243 substrate (anthranilate) binding pocket [chemical binding]; other site 748449001244 product (indole) binding pocket [chemical binding]; other site 748449001245 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 748449001246 active site 748449001247 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 748449001248 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 748449001249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449001250 catalytic residue [active] 748449001251 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 748449001252 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 748449001253 substrate binding site [chemical binding]; other site 748449001254 active site 748449001255 catalytic residues [active] 748449001256 heterodimer interface [polypeptide binding]; other site 748449001257 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 748449001258 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 748449001259 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 748449001260 6-phosphofructokinase; Provisional; Region: PRK03202 748449001261 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 748449001262 active site 748449001263 ADP/pyrophosphate binding site [chemical binding]; other site 748449001264 dimerization interface [polypeptide binding]; other site 748449001265 allosteric effector site; other site 748449001266 fructose-1,6-bisphosphate binding site; other site 748449001267 pyruvate kinase; Provisional; Region: PRK06354 748449001268 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 748449001269 domain interfaces; other site 748449001270 active site 748449001271 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 748449001272 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 748449001273 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449001274 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449001275 putative active site [active] 748449001276 putative NTP binding site [chemical binding]; other site 748449001277 putative nucleic acid binding site [nucleotide binding]; other site 748449001278 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449001279 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748449001280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748449001281 active site 748449001282 phosphorylation site [posttranslational modification] 748449001283 intermolecular recognition site; other site 748449001284 dimerization interface [polypeptide binding]; other site 748449001285 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748449001286 DNA binding site [nucleotide binding] 748449001287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748449001288 HAMP domain; Region: HAMP; pfam00672 748449001289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748449001290 dimer interface [polypeptide binding]; other site 748449001291 phosphorylation site [posttranslational modification] 748449001292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449001293 ATP binding site [chemical binding]; other site 748449001294 Mg2+ binding site [ion binding]; other site 748449001295 G-X-G motif; other site 748449001296 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 748449001297 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 748449001298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748449001299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748449001300 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 748449001301 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748449001302 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 748449001303 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 748449001304 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449001305 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449001306 putative active site [active] 748449001307 putative NTP binding site [chemical binding]; other site 748449001308 putative nucleic acid binding site [nucleotide binding]; other site 748449001309 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449001310 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748449001311 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748449001312 hybrid cluster protein; Provisional; Region: PRK05290 748449001313 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748449001314 ACS interaction site; other site 748449001315 CODH interaction site; other site 748449001316 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 748449001317 hybrid metal cluster; other site 748449001318 Isochorismatase family; Region: Isochorismatase; pfam00857 748449001319 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 748449001320 catalytic triad [active] 748449001321 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 748449001322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748449001323 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748449001324 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 748449001325 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 748449001326 Hemerythrin-like domain; Region: Hr-like; cd12108 748449001327 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748449001328 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 748449001329 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 748449001330 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 748449001331 active site 748449001332 catalytic residues [active] 748449001333 DNA binding site [nucleotide binding] 748449001334 Int/Topo IB signature motif; other site 748449001335 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 748449001336 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748449001337 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 748449001338 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 748449001339 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 748449001340 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 748449001341 CryBP1 protein; Region: CryBP1; pfam07029 748449001342 S-layer homology domain; Region: SLH; pfam00395 748449001343 S-layer homology domain; Region: SLH; pfam00395 748449001344 S-layer homology domain; Region: SLH; pfam00395 748449001345 DNA polymerase I; Provisional; Region: PRK05755 748449001346 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 748449001347 active site 748449001348 metal binding site 1 [ion binding]; metal-binding site 748449001349 putative 5' ssDNA interaction site; other site 748449001350 metal binding site 3; metal-binding site 748449001351 metal binding site 2 [ion binding]; metal-binding site 748449001352 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 748449001353 putative DNA binding site [nucleotide binding]; other site 748449001354 putative metal binding site [ion binding]; other site 748449001355 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 748449001356 active site 748449001357 substrate binding site [chemical binding]; other site 748449001358 catalytic site [active] 748449001359 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 748449001360 active site 748449001361 DNA binding site [nucleotide binding] 748449001362 catalytic site [active] 748449001363 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 748449001364 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 748449001365 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 748449001366 PLD-like domain; Region: PLDc_2; pfam13091 748449001367 putative active site [active] 748449001368 catalytic site [active] 748449001369 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 748449001370 PLD-like domain; Region: PLDc_2; pfam13091 748449001371 putative active site [active] 748449001372 catalytic site [active] 748449001373 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 748449001374 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 748449001375 DNA binding site [nucleotide binding] 748449001376 catalytic residue [active] 748449001377 H2TH interface [polypeptide binding]; other site 748449001378 putative catalytic residues [active] 748449001379 turnover-facilitating residue; other site 748449001380 intercalation triad [nucleotide binding]; other site 748449001381 8OG recognition residue [nucleotide binding]; other site 748449001382 putative reading head residues; other site 748449001383 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 748449001384 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 748449001385 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748449001386 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748449001387 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748449001388 ABC transporter; Region: ABC_tran_2; pfam12848 748449001389 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748449001390 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 748449001391 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 748449001392 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 748449001393 CoA-binding site [chemical binding]; other site 748449001394 ATP-binding [chemical binding]; other site 748449001395 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 748449001396 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 748449001397 N-acetyl-D-glucosamine binding site [chemical binding]; other site 748449001398 catalytic residue [active] 748449001399 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 748449001400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449001401 dimer interface [polypeptide binding]; other site 748449001402 conserved gate region; other site 748449001403 putative PBP binding loops; other site 748449001404 ABC-ATPase subunit interface; other site 748449001405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 748449001406 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 748449001407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449001408 dimer interface [polypeptide binding]; other site 748449001409 conserved gate region; other site 748449001410 putative PBP binding loops; other site 748449001411 ABC-ATPase subunit interface; other site 748449001412 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 748449001413 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748449001414 Walker A/P-loop; other site 748449001415 ATP binding site [chemical binding]; other site 748449001416 Q-loop/lid; other site 748449001417 ABC transporter signature motif; other site 748449001418 Walker B; other site 748449001419 D-loop; other site 748449001420 H-loop/switch region; other site 748449001421 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 748449001422 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 748449001423 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748449001424 Walker A/P-loop; other site 748449001425 ATP binding site [chemical binding]; other site 748449001426 Q-loop/lid; other site 748449001427 ABC transporter signature motif; other site 748449001428 Walker B; other site 748449001429 D-loop; other site 748449001430 H-loop/switch region; other site 748449001431 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 748449001432 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 748449001433 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 748449001434 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 748449001435 UbiA prenyltransferase family; Region: UbiA; pfam01040 748449001436 hypothetical protein; Provisional; Region: PRK10621 748449001437 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 748449001438 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748449001439 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 748449001440 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748449001441 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 748449001442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 748449001443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748449001444 Transposase; Region: HTH_Tnp_1; pfam01527 748449001445 CGGC domain; Region: CGGC; pfam08821 748449001446 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 748449001447 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 748449001448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748449001449 catalytic residue [active] 748449001450 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 748449001451 4Fe-4S binding domain; Region: Fer4; pfam00037 748449001452 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 748449001453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748449001454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748449001455 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 748449001456 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 748449001457 active site 748449001458 catalytic site [active] 748449001459 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 748449001460 putative ligand binding site [chemical binding]; other site 748449001461 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 748449001462 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 748449001463 starch binding site [chemical binding]; other site 748449001464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748449001465 Transposase; Region: HTH_Tnp_1; pfam01527 748449001466 putative transposase OrfB; Reviewed; Region: PHA02517 748449001467 HTH-like domain; Region: HTH_21; pfam13276 748449001468 Integrase core domain; Region: rve; pfam00665 748449001469 Integrase core domain; Region: rve_3; pfam13683 748449001470 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 748449001471 HTH domain; Region: HTH_11; pfam08279 748449001472 Mga helix-turn-helix domain; Region: Mga; pfam05043 748449001473 PRD domain; Region: PRD; pfam00874 748449001474 PRD domain; Region: PRD; pfam00874 748449001475 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 748449001476 active site 748449001477 P-loop; other site 748449001478 phosphorylation site [posttranslational modification] 748449001479 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748449001480 active site 748449001481 phosphorylation site [posttranslational modification] 748449001482 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748449001483 active site 748449001484 phosphorylation site [posttranslational modification] 748449001485 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 748449001486 active site 748449001487 P-loop; other site 748449001488 phosphorylation site [posttranslational modification] 748449001489 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 748449001490 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 748449001491 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 748449001492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449001493 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 748449001494 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 748449001495 dimer interface [polypeptide binding]; other site 748449001496 GEMM cis-regulatory element; Halha_0486 748449001497 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 748449001498 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 748449001499 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 748449001500 active site 748449001501 dimer interface [polypeptide binding]; other site 748449001502 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 748449001503 dimer interface [polypeptide binding]; other site 748449001504 active site 748449001505 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 748449001506 AMIN domain; Region: AMIN; pfam11741 748449001507 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 748449001508 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 748449001509 active site 748449001510 metal binding site [ion binding]; metal-binding site 748449001511 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 748449001512 AMIN domain; Region: AMIN; pfam11741 748449001513 AMIN domain; Region: AMIN; pfam11741 748449001514 AMIN domain; Region: AMIN; pfam11741 748449001515 AMIN domain; Region: AMIN; pfam11741 748449001516 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 748449001517 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 748449001518 active site 748449001519 metal binding site [ion binding]; metal-binding site 748449001520 Sporulation and spore germination; Region: Germane; pfam10646 748449001521 glutamate racemase; Provisional; Region: PRK00865 748449001522 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 748449001523 GTP cyclohydrolase I; Provisional; Region: PLN03044 748449001524 active site 748449001525 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 748449001526 dihydropteroate synthase; Region: DHPS; TIGR01496 748449001527 substrate binding pocket [chemical binding]; other site 748449001528 dimer interface [polypeptide binding]; other site 748449001529 inhibitor binding site; inhibition site 748449001530 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 748449001531 homooctamer interface [polypeptide binding]; other site 748449001532 active site 748449001533 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 748449001534 catalytic center binding site [active] 748449001535 ATP binding site [chemical binding]; other site 748449001536 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 748449001537 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 748449001538 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 748449001539 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 748449001540 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 748449001541 G1 box; other site 748449001542 GTP/Mg2+ binding site [chemical binding]; other site 748449001543 Switch I region; other site 748449001544 G2 box; other site 748449001545 G3 box; other site 748449001546 Switch II region; other site 748449001547 G4 box; other site 748449001548 G5 box; other site 748449001549 Nucleoside recognition; Region: Gate; pfam07670 748449001550 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 748449001551 Nucleoside recognition; Region: Gate; pfam07670 748449001552 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748449001553 metal binding site 2 [ion binding]; metal-binding site 748449001554 putative DNA binding helix; other site 748449001555 metal binding site 1 [ion binding]; metal-binding site 748449001556 dimer interface [polypeptide binding]; other site 748449001557 structural Zn2+ binding site [ion binding]; other site 748449001558 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748449001559 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748449001560 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 748449001561 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 748449001562 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 748449001563 G1 box; other site 748449001564 GTP/Mg2+ binding site [chemical binding]; other site 748449001565 Switch I region; other site 748449001566 G2 box; other site 748449001567 G3 box; other site 748449001568 Switch II region; other site 748449001569 G4 box; other site 748449001570 G5 box; other site 748449001571 Nucleoside recognition; Region: Gate; pfam07670 748449001572 Nucleoside recognition; Region: Gate; pfam07670 748449001573 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 748449001574 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 748449001575 Nucleoside recognition; Region: Gate; pfam07670 748449001576 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 748449001577 EamA-like transporter family; Region: EamA; pfam00892 748449001578 EamA-like transporter family; Region: EamA; pfam00892 748449001579 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 748449001580 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 748449001581 tetramer interface [polypeptide binding]; other site 748449001582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449001583 catalytic residue [active] 748449001584 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 748449001585 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 748449001586 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 748449001587 shikimate binding site; other site 748449001588 NAD(P) binding site [chemical binding]; other site 748449001589 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 748449001590 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748449001591 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748449001592 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 748449001593 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 748449001594 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 748449001595 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 748449001596 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 748449001597 Competence protein A; Region: Competence_A; pfam11104 748449001598 Cell division protein FtsA; Region: FtsA; cl17206 748449001599 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748449001600 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 748449001601 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 748449001602 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 748449001603 Tetramer interface [polypeptide binding]; other site 748449001604 active site 748449001605 FMN-binding site [chemical binding]; other site 748449001606 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 748449001607 Shikimate kinase; Region: SKI; pfam01202 748449001608 ADP binding site [chemical binding]; other site 748449001609 magnesium binding site [ion binding]; other site 748449001610 putative shikimate binding site; other site 748449001611 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 748449001612 active site 748449001613 dimer interface [polypeptide binding]; other site 748449001614 metal binding site [ion binding]; metal-binding site 748449001615 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 748449001616 Dehydroquinase class II; Region: DHquinase_II; pfam01220 748449001617 trimer interface [polypeptide binding]; other site 748449001618 active site 748449001619 dimer interface [polypeptide binding]; other site 748449001620 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 748449001621 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 748449001622 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 748449001623 active site 748449001624 elongation factor P; Validated; Region: PRK00529 748449001625 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 748449001626 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 748449001627 RNA binding site [nucleotide binding]; other site 748449001628 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 748449001629 RNA binding site [nucleotide binding]; other site 748449001630 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 748449001631 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 748449001632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449001633 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748449001634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449001635 DNA binding residues [nucleotide binding] 748449001636 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 748449001637 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 748449001638 Walker A motif; other site 748449001639 ATP binding site [chemical binding]; other site 748449001640 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 748449001641 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 748449001642 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 748449001643 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 748449001644 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 748449001645 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 748449001646 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 748449001647 pyruvate carboxylase subunit B; Validated; Region: PRK09282 748449001648 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 748449001649 active site 748449001650 catalytic residues [active] 748449001651 metal binding site [ion binding]; metal-binding site 748449001652 homodimer binding site [polypeptide binding]; other site 748449001653 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 748449001654 carboxyltransferase (CT) interaction site; other site 748449001655 biotinylation site [posttranslational modification]; other site 748449001656 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 748449001657 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748449001658 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 748449001659 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 748449001660 Asp23 family; Region: Asp23; pfam03780 748449001661 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 748449001662 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 748449001663 putative RNA binding site [nucleotide binding]; other site 748449001664 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 748449001665 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 748449001666 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748449001667 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 748449001668 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 748449001669 putative active site [active] 748449001670 metal binding site [ion binding]; metal-binding site 748449001671 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 748449001672 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 748449001673 FAD binding pocket [chemical binding]; other site 748449001674 FAD binding motif [chemical binding]; other site 748449001675 phosphate binding motif [ion binding]; other site 748449001676 beta-alpha-beta structure motif; other site 748449001677 NAD binding pocket [chemical binding]; other site 748449001678 Iron coordination center [ion binding]; other site 748449001679 putative oxidoreductase; Provisional; Region: PRK12831 748449001680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449001681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449001682 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 748449001683 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 748449001684 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 748449001685 homodimer interface [polypeptide binding]; other site 748449001686 NADP binding site [chemical binding]; other site 748449001687 substrate binding site [chemical binding]; other site 748449001688 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 748449001689 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 748449001690 generic binding surface II; other site 748449001691 generic binding surface I; other site 748449001692 Helix-turn-helix domain; Region: HTH_17; pfam12728 748449001693 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449001694 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449001695 putative active site [active] 748449001696 putative NTP binding site [chemical binding]; other site 748449001697 putative nucleic acid binding site [nucleotide binding]; other site 748449001698 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449001699 plasmid segregation protein ParM; Provisional; Region: PRK13917 748449001700 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 748449001701 Mg binding site [ion binding]; other site 748449001702 nucleotide binding site [chemical binding]; other site 748449001703 putative protofilament interface [polypeptide binding]; other site 748449001704 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 748449001705 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 748449001706 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 748449001707 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 748449001708 substrate binding pocket [chemical binding]; other site 748449001709 chain length determination region; other site 748449001710 substrate-Mg2+ binding site; other site 748449001711 catalytic residues [active] 748449001712 aspartate-rich region 1; other site 748449001713 active site lid residues [active] 748449001714 aspartate-rich region 2; other site 748449001715 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 748449001716 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 748449001717 TPP-binding site; other site 748449001718 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 748449001719 PYR/PP interface [polypeptide binding]; other site 748449001720 dimer interface [polypeptide binding]; other site 748449001721 TPP binding site [chemical binding]; other site 748449001722 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 748449001723 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 748449001724 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748449001725 RNA binding surface [nucleotide binding]; other site 748449001726 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 748449001727 ATP-NAD kinase; Region: NAD_kinase; pfam01513 748449001728 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 748449001729 arginine repressor; Provisional; Region: PRK04280 748449001730 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 748449001731 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 748449001732 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 748449001733 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 748449001734 Walker A/P-loop; other site 748449001735 ATP binding site [chemical binding]; other site 748449001736 Q-loop/lid; other site 748449001737 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 748449001738 ABC transporter signature motif; other site 748449001739 Walker B; other site 748449001740 D-loop; other site 748449001741 H-loop/switch region; other site 748449001742 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 748449001743 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 748449001744 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 748449001745 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 748449001746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748449001747 active site 748449001748 phosphorylation site [posttranslational modification] 748449001749 intermolecular recognition site; other site 748449001750 dimerization interface [polypeptide binding]; other site 748449001751 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 748449001752 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 748449001753 Thiamine pyrophosphokinase; Region: TPK; cl08415 748449001754 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 748449001755 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 748449001756 Ligand binding site; other site 748449001757 Putative Catalytic site; other site 748449001758 DXD motif; other site 748449001759 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 748449001760 Mg++ binding site [ion binding]; other site 748449001761 putative catalytic motif [active] 748449001762 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 748449001763 Na2 binding site [ion binding]; other site 748449001764 putative substrate binding site 1 [chemical binding]; other site 748449001765 Na binding site 1 [ion binding]; other site 748449001766 putative substrate binding site 2 [chemical binding]; other site 748449001767 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 748449001768 peptidase T-like protein; Region: PepT-like; TIGR01883 748449001769 metal binding site [ion binding]; metal-binding site 748449001770 putative dimer interface [polypeptide binding]; other site 748449001771 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 748449001772 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 748449001773 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 748449001774 dimer interface [polypeptide binding]; other site 748449001775 ADP-ribose binding site [chemical binding]; other site 748449001776 active site 748449001777 nudix motif; other site 748449001778 metal binding site [ion binding]; metal-binding site 748449001779 Integral membrane protein DUF95; Region: DUF95; cl00572 748449001780 phosphopentomutase; Provisional; Region: PRK05362 748449001781 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 748449001782 purine nucleoside phosphorylase; Provisional; Region: PRK08202 748449001783 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 748449001784 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 748449001785 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 748449001786 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748449001787 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 748449001788 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 748449001789 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 748449001790 anti sigma factor interaction site; other site 748449001791 regulatory phosphorylation site [posttranslational modification]; other site 748449001792 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 748449001793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449001794 ATP binding site [chemical binding]; other site 748449001795 Mg2+ binding site [ion binding]; other site 748449001796 G-X-G motif; other site 748449001797 sporulation sigma factor SigF; Validated; Region: PRK05572 748449001798 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449001799 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748449001800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449001801 DNA binding residues [nucleotide binding] 748449001802 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 748449001803 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 748449001804 SpoVA protein; Region: SpoVA; cl04298 748449001805 stage V sporulation protein AD; Validated; Region: PRK08304 748449001806 stage V sporulation protein AD; Provisional; Region: PRK12404 748449001807 SpoVA protein; Region: SpoVA; cl04298 748449001808 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 748449001809 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748449001810 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 748449001811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 748449001812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 748449001813 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 748449001814 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 748449001815 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 748449001816 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 748449001817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748449001818 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 748449001819 DNA-binding interface [nucleotide binding]; DNA binding site 748449001820 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 748449001821 diaminopimelate decarboxylase; Region: lysA; TIGR01048 748449001822 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 748449001823 active site 748449001824 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748449001825 substrate binding site [chemical binding]; other site 748449001826 catalytic residues [active] 748449001827 dimer interface [polypeptide binding]; other site 748449001828 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 748449001829 FOG: CBS domain [General function prediction only]; Region: COG0517 748449001830 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 748449001831 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 748449001832 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 748449001833 active site 748449001834 NTP binding site [chemical binding]; other site 748449001835 metal binding triad [ion binding]; metal-binding site 748449001836 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 748449001837 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 748449001838 Peptidase family M50; Region: Peptidase_M50; pfam02163 748449001839 active site 748449001840 putative substrate binding region [chemical binding]; other site 748449001841 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 748449001842 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 748449001843 active site 748449001844 HIGH motif; other site 748449001845 dimer interface [polypeptide binding]; other site 748449001846 KMSKS motif; other site 748449001847 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 748449001848 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 748449001849 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748449001850 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 748449001851 Walker A/P-loop; other site 748449001852 ATP binding site [chemical binding]; other site 748449001853 Q-loop/lid; other site 748449001854 ABC transporter signature motif; other site 748449001855 Walker B; other site 748449001856 D-loop; other site 748449001857 H-loop/switch region; other site 748449001858 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 748449001859 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 748449001860 putative ligand binding residues [chemical binding]; other site 748449001861 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 748449001862 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748449001863 ABC-ATPase subunit interface; other site 748449001864 dimer interface [polypeptide binding]; other site 748449001865 putative PBP binding regions; other site 748449001866 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 748449001867 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748449001868 ABC-ATPase subunit interface; other site 748449001869 dimer interface [polypeptide binding]; other site 748449001870 putative PBP binding regions; other site 748449001871 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 748449001872 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 748449001873 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 748449001874 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748449001875 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 748449001876 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 748449001877 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748449001878 RNA binding surface [nucleotide binding]; other site 748449001879 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 748449001880 active site 748449001881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449001882 Radical SAM superfamily; Region: Radical_SAM; pfam04055 748449001883 FeS/SAM binding site; other site 748449001884 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 748449001885 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 748449001886 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 748449001887 Walker A/P-loop; other site 748449001888 ATP binding site [chemical binding]; other site 748449001889 Q-loop/lid; other site 748449001890 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 748449001891 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 748449001892 ABC transporter signature motif; other site 748449001893 Walker B; other site 748449001894 D-loop; other site 748449001895 H-loop/switch region; other site 748449001896 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 748449001897 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 748449001898 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748449001899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449001900 DNA binding residues [nucleotide binding] 748449001901 signal recognition particle protein; Provisional; Region: PRK10867 748449001902 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 748449001903 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 748449001904 P loop; other site 748449001905 GTP binding site [chemical binding]; other site 748449001906 Signal peptide binding domain; Region: SRP_SPB; pfam02978 748449001907 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 748449001908 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 748449001909 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 748449001910 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 748449001911 RimM N-terminal domain; Region: RimM; pfam01782 748449001912 PRC-barrel domain; Region: PRC; pfam05239 748449001913 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 748449001914 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 748449001915 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 748449001916 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 748449001917 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 748449001918 Catalytic site [active] 748449001919 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 748449001920 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 748449001921 GTP/Mg2+ binding site [chemical binding]; other site 748449001922 G4 box; other site 748449001923 G5 box; other site 748449001924 G1 box; other site 748449001925 Switch I region; other site 748449001926 G2 box; other site 748449001927 G3 box; other site 748449001928 Switch II region; other site 748449001929 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 748449001930 RNA/DNA hybrid binding site [nucleotide binding]; other site 748449001931 active site 748449001932 hypothetical protein; Reviewed; Region: PRK12497 748449001933 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 748449001934 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 748449001935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449001936 Walker A motif; other site 748449001937 ATP binding site [chemical binding]; other site 748449001938 Walker B motif; other site 748449001939 arginine finger; other site 748449001940 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 748449001941 Carbohydrate binding domain; Region: CBM_25; smart01066 748449001942 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 748449001943 dinuclear metal binding motif [ion binding]; other site 748449001944 DNA protecting protein DprA; Region: dprA; TIGR00732 748449001945 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 748449001946 DNA topoisomerase I; Validated; Region: PRK05582 748449001947 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 748449001948 active site 748449001949 interdomain interaction site; other site 748449001950 putative metal-binding site [ion binding]; other site 748449001951 nucleotide binding site [chemical binding]; other site 748449001952 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 748449001953 domain I; other site 748449001954 DNA binding groove [nucleotide binding] 748449001955 phosphate binding site [ion binding]; other site 748449001956 domain II; other site 748449001957 domain III; other site 748449001958 nucleotide binding site [chemical binding]; other site 748449001959 catalytic site [active] 748449001960 domain IV; other site 748449001961 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 748449001962 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 748449001963 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 748449001964 active site 748449001965 HslU subunit interaction site [polypeptide binding]; other site 748449001966 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 748449001967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449001968 Walker A motif; other site 748449001969 ATP binding site [chemical binding]; other site 748449001970 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 748449001971 Walker B motif; other site 748449001972 arginine finger; other site 748449001973 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 748449001974 transcriptional repressor CodY; Validated; Region: PRK04158 748449001975 CodY GAF-like domain; Region: CodY; pfam06018 748449001976 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 748449001977 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 748449001978 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 748449001979 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 748449001980 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 748449001981 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 748449001982 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 748449001983 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 748449001984 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 748449001985 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 748449001986 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 748449001987 FliG C-terminal domain; Region: FliG_C; pfam01706 748449001988 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 748449001989 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 748449001990 Flagellar assembly protein FliH; Region: FliH; pfam02108 748449001991 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 748449001992 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 748449001993 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 748449001994 Walker A motif/ATP binding site; other site 748449001995 Walker B motif; other site 748449001996 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 748449001997 Uncharacterized conserved protein [Function unknown]; Region: COG3334 748449001998 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 748449001999 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 748449002000 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 748449002001 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 748449002002 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 748449002003 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 748449002004 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 748449002005 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 748449002006 Flagellar protein (FlbD); Region: FlbD; pfam06289 748449002007 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 748449002008 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 748449002009 flagellar motor protein MotS; Reviewed; Region: PRK06925 748449002010 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 748449002011 ligand binding site [chemical binding]; other site 748449002012 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 748449002013 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 748449002014 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 748449002015 flagellar motor switch protein; Validated; Region: PRK08119 748449002016 CheC-like family; Region: CheC; pfam04509 748449002017 CheC-like family; Region: CheC; pfam04509 748449002018 flagellar motor switch protein FliN; Region: fliN; TIGR02480 748449002019 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 748449002020 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 748449002021 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 748449002022 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 748449002023 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 748449002024 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 748449002025 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 748449002026 FHIPEP family; Region: FHIPEP; pfam00771 748449002027 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 748449002028 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748449002029 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 748449002030 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 748449002031 P-loop; other site 748449002032 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 748449002033 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 748449002034 Flagellar protein YcgR; Region: YcgR_2; pfam12945 748449002035 PilZ domain; Region: PilZ; pfam07238 748449002036 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 748449002037 CheC-like family; Region: CheC; pfam04509 748449002038 CheC-like family; Region: CheC; pfam04509 748449002039 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 748449002040 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 748449002041 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449002042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449002043 DNA binding residues [nucleotide binding] 748449002044 Protein of unknown function (DUF342); Region: DUF342; pfam03961 748449002045 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 748449002046 YceG-like family; Region: YceG; pfam02618 748449002047 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 748449002048 rRNA interaction site [nucleotide binding]; other site 748449002049 S8 interaction site; other site 748449002050 putative laminin-1 binding site; other site 748449002051 elongation factor Ts; Provisional; Region: tsf; PRK09377 748449002052 UBA/TS-N domain; Region: UBA; pfam00627 748449002053 Elongation factor TS; Region: EF_TS; pfam00889 748449002054 Elongation factor TS; Region: EF_TS; pfam00889 748449002055 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 748449002056 putative nucleotide binding site [chemical binding]; other site 748449002057 uridine monophosphate binding site [chemical binding]; other site 748449002058 homohexameric interface [polypeptide binding]; other site 748449002059 ribosome recycling factor; Reviewed; Region: frr; PRK00083 748449002060 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 748449002061 hinge region; other site 748449002062 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 748449002063 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 748449002064 catalytic residue [active] 748449002065 putative FPP diphosphate binding site; other site 748449002066 putative FPP binding hydrophobic cleft; other site 748449002067 dimer interface [polypeptide binding]; other site 748449002068 putative IPP diphosphate binding site; other site 748449002069 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 748449002070 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 748449002071 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 748449002072 Domain of unknown function DUF20; Region: UPF0118; pfam01594 748449002073 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 748449002074 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 748449002075 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 748449002076 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 748449002077 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 748449002078 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 748449002079 active site 748449002080 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 748449002081 protein binding site [polypeptide binding]; other site 748449002082 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 748449002083 putative substrate binding region [chemical binding]; other site 748449002084 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449002085 Zn2+ binding site [ion binding]; other site 748449002086 Mg2+ binding site [ion binding]; other site 748449002087 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 748449002088 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 748449002089 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 748449002090 prolyl-tRNA synthetase; Provisional; Region: PRK09194 748449002091 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 748449002092 dimer interface [polypeptide binding]; other site 748449002093 motif 1; other site 748449002094 active site 748449002095 motif 2; other site 748449002096 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 748449002097 putative deacylase active site [active] 748449002098 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 748449002099 active site 748449002100 motif 3; other site 748449002101 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 748449002102 anticodon binding site; other site 748449002103 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 748449002104 Ligand binding site; other site 748449002105 Putative Catalytic site; other site 748449002106 DXD motif; other site 748449002107 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 748449002108 MgtC family; Region: MgtC; pfam02308 748449002109 DNA polymerase III PolC; Validated; Region: polC; PRK00448 748449002110 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 748449002111 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 748449002112 generic binding surface II; other site 748449002113 generic binding surface I; other site 748449002114 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 748449002115 active site 748449002116 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 748449002117 active site 748449002118 catalytic site [active] 748449002119 substrate binding site [chemical binding]; other site 748449002120 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 748449002121 ribosome maturation protein RimP; Reviewed; Region: PRK00092 748449002122 Sm and related proteins; Region: Sm_like; cl00259 748449002123 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 748449002124 putative oligomer interface [polypeptide binding]; other site 748449002125 putative RNA binding site [nucleotide binding]; other site 748449002126 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 748449002127 NusA N-terminal domain; Region: NusA_N; pfam08529 748449002128 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 748449002129 RNA binding site [nucleotide binding]; other site 748449002130 homodimer interface [polypeptide binding]; other site 748449002131 NusA-like KH domain; Region: KH_5; pfam13184 748449002132 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 748449002133 G-X-X-G motif; other site 748449002134 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 748449002135 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 748449002136 translation initiation factor IF-2; Region: IF-2; TIGR00487 748449002137 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 748449002138 G1 box; other site 748449002139 putative GEF interaction site [polypeptide binding]; other site 748449002140 GTP/Mg2+ binding site [chemical binding]; other site 748449002141 Switch I region; other site 748449002142 G2 box; other site 748449002143 G3 box; other site 748449002144 Switch II region; other site 748449002145 G4 box; other site 748449002146 G5 box; other site 748449002147 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 748449002148 Translation-initiation factor 2; Region: IF-2; pfam11987 748449002149 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 748449002150 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 748449002151 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 748449002152 DHH family; Region: DHH; pfam01368 748449002153 DHHA1 domain; Region: DHHA1; pfam02272 748449002154 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 748449002155 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 748449002156 active site 748449002157 Riboflavin kinase; Region: Flavokinase; pfam01687 748449002158 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 748449002159 16S/18S rRNA binding site [nucleotide binding]; other site 748449002160 S13e-L30e interaction site [polypeptide binding]; other site 748449002161 25S rRNA binding site [nucleotide binding]; other site 748449002162 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 748449002163 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 748449002164 RNase E interface [polypeptide binding]; other site 748449002165 trimer interface [polypeptide binding]; other site 748449002166 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 748449002167 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 748449002168 RNase E interface [polypeptide binding]; other site 748449002169 trimer interface [polypeptide binding]; other site 748449002170 active site 748449002171 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 748449002172 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 748449002173 RNA binding site [nucleotide binding]; other site 748449002174 domain interface; other site 748449002175 endonuclease IV; Provisional; Region: PRK01060 748449002176 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 748449002177 AP (apurinic/apyrimidinic) site pocket; other site 748449002178 DNA interaction; other site 748449002179 Metal-binding active site; metal-binding site 748449002180 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449002181 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 748449002182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449002183 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748449002184 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449002185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449002186 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449002187 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748449002188 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 748449002189 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 748449002190 active site 748449002191 metal binding site [ion binding]; metal-binding site 748449002192 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 748449002193 NodB motif; other site 748449002194 active site 748449002195 catalytic site [active] 748449002196 metal binding site [ion binding]; metal-binding site 748449002197 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 748449002198 NodB motif; other site 748449002199 VanW like protein; Region: VanW; pfam04294 748449002200 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 748449002201 trimer interface [polypeptide binding]; other site 748449002202 active site 748449002203 Cache domain; Region: Cache_1; pfam02743 748449002204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449002205 dimerization interface [polypeptide binding]; other site 748449002206 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449002207 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449002208 dimer interface [polypeptide binding]; other site 748449002209 putative CheW interface [polypeptide binding]; other site 748449002210 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 748449002211 dihydrodipicolinate reductase; Provisional; Region: PRK00048 748449002212 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 748449002213 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 748449002214 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 748449002215 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 748449002216 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 748449002217 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 748449002218 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 748449002219 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 748449002220 aspartate kinase I; Reviewed; Region: PRK08210 748449002221 nucleotide binding site [chemical binding]; other site 748449002222 substrate binding site [chemical binding]; other site 748449002223 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 748449002224 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 748449002225 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 748449002226 dihydrodipicolinate synthase; Region: dapA; TIGR00674 748449002227 dimer interface [polypeptide binding]; other site 748449002228 active site 748449002229 catalytic residue [active] 748449002230 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 748449002231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748449002232 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 748449002233 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748449002234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449002235 binding surface 748449002236 TPR motif; other site 748449002237 TPR repeat; Region: TPR_11; pfam13414 748449002238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449002239 binding surface 748449002240 TPR repeat; Region: TPR_11; pfam13414 748449002241 TPR motif; other site 748449002242 QueT transporter; Region: QueT; pfam06177 748449002243 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 748449002244 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 748449002245 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748449002246 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 748449002247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449002248 motif II; other site 748449002249 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 748449002250 Clp protease; Region: CLP_protease; pfam00574 748449002251 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 748449002252 active site 748449002253 YlzJ-like protein; Region: YlzJ; pfam14035 748449002254 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 748449002255 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 748449002256 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 748449002257 Bacitracin resistance protein BacA; Region: BacA; pfam02673 748449002258 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 748449002259 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 748449002260 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 748449002261 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 748449002262 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748449002263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748449002264 DNA-binding site [nucleotide binding]; DNA binding site 748449002265 UTRA domain; Region: UTRA; pfam07702 748449002266 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 748449002267 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 748449002268 ligand binding site [chemical binding]; other site 748449002269 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 748449002270 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 748449002271 Walker A/P-loop; other site 748449002272 ATP binding site [chemical binding]; other site 748449002273 Q-loop/lid; other site 748449002274 ABC transporter signature motif; other site 748449002275 Walker B; other site 748449002276 D-loop; other site 748449002277 H-loop/switch region; other site 748449002278 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 748449002279 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748449002280 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 748449002281 TM-ABC transporter signature motif; other site 748449002282 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748449002283 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 748449002284 TM-ABC transporter signature motif; other site 748449002285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748449002286 non-specific DNA binding site [nucleotide binding]; other site 748449002287 salt bridge; other site 748449002288 sequence-specific DNA binding site [nucleotide binding]; other site 748449002289 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748449002290 CAAX protease self-immunity; Region: Abi; pfam02517 748449002291 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 748449002292 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 748449002293 dimer interface [polypeptide binding]; other site 748449002294 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 748449002295 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 748449002296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449002297 ATP binding site [chemical binding]; other site 748449002298 putative Mg++ binding site [ion binding]; other site 748449002299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449002300 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 748449002301 nucleotide binding region [chemical binding]; other site 748449002302 ATP-binding site [chemical binding]; other site 748449002303 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 748449002304 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 748449002305 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 748449002306 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 748449002307 heterotetramer interface [polypeptide binding]; other site 748449002308 active site pocket [active] 748449002309 cleavage site 748449002310 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 748449002311 feedback inhibition sensing region; other site 748449002312 homohexameric interface [polypeptide binding]; other site 748449002313 nucleotide binding site [chemical binding]; other site 748449002314 N-acetyl-L-glutamate binding site [chemical binding]; other site 748449002315 acetylornithine aminotransferase; Provisional; Region: PRK02627 748449002316 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 748449002317 inhibitor-cofactor binding pocket; inhibition site 748449002318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449002319 catalytic residue [active] 748449002320 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 748449002321 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 748449002322 putative substrate binding site [chemical binding]; other site 748449002323 putative ATP binding site [chemical binding]; other site 748449002324 FOG: CBS domain [General function prediction only]; Region: COG0517 748449002325 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 748449002326 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 748449002327 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 748449002328 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 748449002329 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 748449002330 Esterase/lipase [General function prediction only]; Region: COG1647 748449002331 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 748449002332 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449002333 Zn2+ binding site [ion binding]; other site 748449002334 Mg2+ binding site [ion binding]; other site 748449002335 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 748449002336 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 748449002337 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 748449002338 catalytic site [active] 748449002339 subunit interface [polypeptide binding]; other site 748449002340 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 748449002341 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748449002342 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 748449002343 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 748449002344 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748449002345 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748449002346 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 748449002347 IMP binding site; other site 748449002348 dimer interface [polypeptide binding]; other site 748449002349 interdomain contacts; other site 748449002350 partial ornithine binding site; other site 748449002351 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 748449002352 Predicted membrane protein [Function unknown]; Region: COG2323 748449002353 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748449002354 metal-binding site [ion binding] 748449002355 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 748449002356 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748449002357 metal-binding site [ion binding] 748449002358 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748449002359 Soluble P-type ATPase [General function prediction only]; Region: COG4087 748449002360 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 748449002361 putative homodimer interface [polypeptide binding]; other site 748449002362 putative homotetramer interface [polypeptide binding]; other site 748449002363 putative allosteric switch controlling residues; other site 748449002364 putative metal binding site [ion binding]; other site 748449002365 putative homodimer-homodimer interface [polypeptide binding]; other site 748449002366 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748449002367 metal-binding site [ion binding] 748449002368 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449002369 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449002370 dimer interface [polypeptide binding]; other site 748449002371 putative CheW interface [polypeptide binding]; other site 748449002372 Hemerythrin; Region: Hemerythrin; cd12107 748449002373 Fe binding site [ion binding]; other site 748449002374 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 748449002375 Bacterial transcriptional activator domain; Region: BTAD; smart01043 748449002376 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 748449002377 zinc transporter ZupT; Provisional; Region: PRK04201 748449002378 ZIP Zinc transporter; Region: Zip; pfam02535 748449002379 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 748449002380 Rubredoxin; Region: Rubredoxin; pfam00301 748449002381 iron binding site [ion binding]; other site 748449002382 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 748449002383 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 748449002384 non-heme iron binding site [ion binding]; other site 748449002385 dimer interface [polypeptide binding]; other site 748449002386 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 748449002387 non-heme iron binding site [ion binding]; other site 748449002388 Rubrerythrin [Energy production and conversion]; Region: COG1592 748449002389 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 748449002390 binuclear metal center [ion binding]; other site 748449002391 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 748449002392 iron binding site [ion binding]; other site 748449002393 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 748449002394 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748449002395 Flavodoxin; Region: Flavodoxin_1; pfam00258 748449002396 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 748449002397 dimer interface [polypeptide binding]; other site 748449002398 substrate binding site [chemical binding]; other site 748449002399 ATP binding site [chemical binding]; other site 748449002400 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 748449002401 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 748449002402 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748449002403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748449002404 DNA-binding site [nucleotide binding]; DNA binding site 748449002405 UTRA domain; Region: UTRA; pfam07702 748449002406 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 748449002407 active site 748449002408 substrate binding pocket [chemical binding]; other site 748449002409 homodimer interaction site [polypeptide binding]; other site 748449002410 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748449002411 active site 748449002412 phosphorylation site [posttranslational modification] 748449002413 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 748449002414 active site 748449002415 P-loop; other site 748449002416 phosphorylation site [posttranslational modification] 748449002417 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 748449002418 Creatinine amidohydrolase; Region: Creatininase; pfam02633 748449002419 hypothetical protein; Provisional; Region: PRK02947 748449002420 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 748449002421 putative active site [active] 748449002422 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 748449002423 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 748449002424 active site 748449002425 trimer interface [polypeptide binding]; other site 748449002426 allosteric site; other site 748449002427 active site lid [active] 748449002428 hexamer (dimer of trimers) interface [polypeptide binding]; other site 748449002429 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 748449002430 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 748449002431 active site 748449002432 dimer interface [polypeptide binding]; other site 748449002433 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 748449002434 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 748449002435 Uncharacterized conserved protein [Function unknown]; Region: COG1633 748449002436 diiron binding motif [ion binding]; other site 748449002437 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748449002438 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 748449002439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 748449002440 NAD(P) binding site [chemical binding]; other site 748449002441 active site 748449002442 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 748449002443 Sulfatase; Region: Sulfatase; cl17466 748449002444 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 748449002445 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 748449002446 Ligand binding site; other site 748449002447 Putative Catalytic site; other site 748449002448 DXD motif; other site 748449002449 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 748449002450 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 748449002451 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 748449002452 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 748449002453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449002454 dimer interface [polypeptide binding]; other site 748449002455 conserved gate region; other site 748449002456 putative PBP binding loops; other site 748449002457 ABC-ATPase subunit interface; other site 748449002458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449002459 dimer interface [polypeptide binding]; other site 748449002460 conserved gate region; other site 748449002461 putative PBP binding loops; other site 748449002462 ABC-ATPase subunit interface; other site 748449002463 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 748449002464 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 748449002465 Walker A/P-loop; other site 748449002466 ATP binding site [chemical binding]; other site 748449002467 Q-loop/lid; other site 748449002468 ABC transporter signature motif; other site 748449002469 Walker B; other site 748449002470 D-loop; other site 748449002471 H-loop/switch region; other site 748449002472 hydroxylamine reductase; Provisional; Region: PRK12310 748449002473 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 748449002474 cubane metal cluster [ion binding]; other site 748449002475 hybrid metal cluster; other site 748449002476 hypothetical protein; Provisional; Region: PRK06851 748449002477 NTPase; Region: NTPase_1; cl17478 748449002478 FlaG protein; Region: FlaG; cl00591 748449002479 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 748449002480 active site 748449002481 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 748449002482 dimer interface [polypeptide binding]; other site 748449002483 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 748449002484 Ligand Binding Site [chemical binding]; other site 748449002485 Molecular Tunnel; other site 748449002486 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748449002487 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 748449002488 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 748449002489 Nitrogen regulatory protein P-II; Region: P-II; smart00938 748449002490 ornithine carbamoyltransferase; Provisional; Region: PRK00779 748449002491 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748449002492 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748449002493 Short C-terminal domain; Region: SHOCT; pfam09851 748449002494 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 748449002495 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 748449002496 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 748449002497 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748449002498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748449002499 active site 748449002500 phosphorylation site [posttranslational modification] 748449002501 intermolecular recognition site; other site 748449002502 dimerization interface [polypeptide binding]; other site 748449002503 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748449002504 DNA binding site [nucleotide binding] 748449002505 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449002506 dimerization interface [polypeptide binding]; other site 748449002507 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 748449002508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748449002509 dimer interface [polypeptide binding]; other site 748449002510 phosphorylation site [posttranslational modification] 748449002511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449002512 ATP binding site [chemical binding]; other site 748449002513 Mg2+ binding site [ion binding]; other site 748449002514 G-X-G motif; other site 748449002515 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748449002516 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748449002517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449002518 Walker A/P-loop; other site 748449002519 ATP binding site [chemical binding]; other site 748449002520 Q-loop/lid; other site 748449002521 ABC transporter signature motif; other site 748449002522 Walker B; other site 748449002523 D-loop; other site 748449002524 H-loop/switch region; other site 748449002525 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748449002526 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748449002527 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 748449002528 Walker A/P-loop; other site 748449002529 ATP binding site [chemical binding]; other site 748449002530 Q-loop/lid; other site 748449002531 ABC transporter signature motif; other site 748449002532 Walker B; other site 748449002533 D-loop; other site 748449002534 H-loop/switch region; other site 748449002535 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 748449002536 Transposase; Region: HTH_Tnp_1; cl17663 748449002537 Cupin domain; Region: Cupin_2; cl17218 748449002538 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 748449002539 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449002540 FeS/SAM binding site; other site 748449002541 hypothetical protein; Provisional; Region: PRK10977 748449002542 Pyruvate formate lyase; Region: PFL; pfam02901 748449002543 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 748449002544 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 748449002545 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 748449002546 putative substrate binding site [chemical binding]; other site 748449002547 putative ATP binding site [chemical binding]; other site 748449002548 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449002549 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449002550 DNA binding site [nucleotide binding] 748449002551 domain linker motif; other site 748449002552 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 748449002553 dimerization interface [polypeptide binding]; other site 748449002554 ligand binding site [chemical binding]; other site 748449002555 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 748449002556 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748449002557 active site turn [active] 748449002558 phosphorylation site [posttranslational modification] 748449002559 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748449002560 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 748449002561 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 748449002562 substrate binding [chemical binding]; other site 748449002563 active site 748449002564 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 748449002565 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 748449002566 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 748449002567 active site 748449002568 catalytic site [active] 748449002569 PBP superfamily domain; Region: PBP_like_2; cl17296 748449002570 PBP superfamily domain; Region: PBP_like_2; cl17296 748449002571 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 748449002572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449002573 dimer interface [polypeptide binding]; other site 748449002574 conserved gate region; other site 748449002575 putative PBP binding loops; other site 748449002576 ABC-ATPase subunit interface; other site 748449002577 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 748449002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449002579 dimer interface [polypeptide binding]; other site 748449002580 conserved gate region; other site 748449002581 putative PBP binding loops; other site 748449002582 ABC-ATPase subunit interface; other site 748449002583 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 748449002584 HAMP domain; Region: HAMP; pfam00672 748449002585 dimerization interface [polypeptide binding]; other site 748449002586 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449002587 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449002588 dimer interface [polypeptide binding]; other site 748449002589 putative CheW interface [polypeptide binding]; other site 748449002590 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 748449002591 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 748449002592 Walker A/P-loop; other site 748449002593 ATP binding site [chemical binding]; other site 748449002594 Q-loop/lid; other site 748449002595 ABC transporter signature motif; other site 748449002596 Walker B; other site 748449002597 D-loop; other site 748449002598 H-loop/switch region; other site 748449002599 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 748449002600 PhoU domain; Region: PhoU; pfam01895 748449002601 PhoU domain; Region: PhoU; pfam01895 748449002602 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 748449002603 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 748449002604 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 748449002605 PhoU domain; Region: PhoU; pfam01895 748449002606 PhoU domain; Region: PhoU; pfam01895 748449002607 HlyD family secretion protein; Region: HlyD_2; pfam12700 748449002608 putative membrane fusion protein; Region: TIGR02828 748449002609 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 748449002610 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748449002611 catalytic residue [active] 748449002612 Protein of unknown function (DUF552); Region: DUF552; pfam04472 748449002613 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 748449002614 pyrroline-5-carboxylate reductase; Region: PLN02688 748449002615 YGGT family; Region: YGGT; pfam02325 748449002616 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 748449002617 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748449002618 RNA binding surface [nucleotide binding]; other site 748449002619 DivIVA domain; Region: DivI1A_domain; TIGR03544 748449002620 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 748449002621 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 748449002622 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 748449002623 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 748449002624 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 748449002625 HIGH motif; other site 748449002626 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 748449002627 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 748449002628 active site 748449002629 KMSKS motif; other site 748449002630 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 748449002631 tRNA binding surface [nucleotide binding]; other site 748449002632 anticodon binding site; other site 748449002633 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 748449002634 Domain of unknown function (DUF370); Region: DUF370; cl00898 748449002635 Guanylate kinase; Region: Guanylate_kin; pfam00625 748449002636 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 748449002637 catalytic site [active] 748449002638 G-X2-G-X-G-K; other site 748449002639 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 748449002640 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 748449002641 Flavoprotein; Region: Flavoprotein; pfam02441 748449002642 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 748449002643 S-ribosylhomocysteinase; Provisional; Region: PRK02260 748449002644 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 748449002645 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 748449002646 zinc binding site [ion binding]; other site 748449002647 putative ligand binding site [chemical binding]; other site 748449002648 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748449002649 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 748449002650 TM-ABC transporter signature motif; other site 748449002651 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 748449002652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449002653 Walker A/P-loop; other site 748449002654 ATP binding site [chemical binding]; other site 748449002655 Q-loop/lid; other site 748449002656 ABC transporter signature motif; other site 748449002657 Walker B; other site 748449002658 D-loop; other site 748449002659 H-loop/switch region; other site 748449002660 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 748449002661 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 748449002662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748449002663 putative substrate translocation pore; other site 748449002664 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449002665 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 748449002666 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 748449002667 NodB motif; other site 748449002668 active site 748449002669 catalytic site [active] 748449002670 metal binding site [ion binding]; metal-binding site 748449002671 S-adenosylmethionine synthetase; Validated; Region: PRK05250 748449002672 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 748449002673 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 748449002674 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 748449002675 Nitroreductase family; Region: Nitroreductase; pfam00881 748449002676 FMN binding site [chemical binding]; other site 748449002677 dimer interface [polypeptide binding]; other site 748449002678 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 748449002679 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 748449002680 NAD binding site [chemical binding]; other site 748449002681 ligand binding site [chemical binding]; other site 748449002682 catalytic site [active] 748449002683 methionine sulfoxide reductase A; Provisional; Region: PRK14054 748449002684 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 748449002685 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748449002686 Predicted membrane protein [Function unknown]; Region: COG2364 748449002687 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748449002688 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748449002689 Restriction endonuclease; Region: Mrr_cat; pfam04471 748449002690 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748449002691 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748449002692 metal binding site [ion binding]; metal-binding site 748449002693 active site 748449002694 I-site; other site 748449002695 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748449002696 Uncharacterized conserved protein [Function unknown]; Region: COG3339 748449002697 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 748449002698 primosome assembly protein PriA; Validated; Region: PRK05580 748449002699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449002700 ATP binding site [chemical binding]; other site 748449002701 putative Mg++ binding site [ion binding]; other site 748449002702 helicase superfamily c-terminal domain; Region: HELICc; smart00490 748449002703 ATP-binding site [chemical binding]; other site 748449002704 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 748449002705 active site 748449002706 catalytic residues [active] 748449002707 metal binding site [ion binding]; metal-binding site 748449002708 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 748449002709 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 748449002710 putative active site [active] 748449002711 substrate binding site [chemical binding]; other site 748449002712 putative cosubstrate binding site; other site 748449002713 catalytic site [active] 748449002714 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 748449002715 substrate binding site [chemical binding]; other site 748449002716 Protein of unknown function DUF116; Region: DUF116; pfam01976 748449002717 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 748449002718 16S rRNA methyltransferase B; Provisional; Region: PRK14902 748449002719 NusB family; Region: NusB; pfam01029 748449002720 putative RNA binding site [nucleotide binding]; other site 748449002721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449002722 S-adenosylmethionine binding site [chemical binding]; other site 748449002723 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 748449002724 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449002725 FeS/SAM binding site; other site 748449002726 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 748449002727 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 748449002728 phosphopeptide binding site; other site 748449002729 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 748449002730 Protein phosphatase 2C; Region: PP2C; pfam00481 748449002731 active site 748449002732 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 748449002733 Catalytic domain of Protein Kinases; Region: PKc; cd00180 748449002734 active site 748449002735 ATP binding site [chemical binding]; other site 748449002736 substrate binding site [chemical binding]; other site 748449002737 activation loop (A-loop); other site 748449002738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 748449002739 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 748449002740 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 748449002741 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 748449002742 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 748449002743 GTPase RsgA; Reviewed; Region: PRK00098 748449002744 RNA binding site [nucleotide binding]; other site 748449002745 homodimer interface [polypeptide binding]; other site 748449002746 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 748449002747 GTPase/Zn-binding domain interface [polypeptide binding]; other site 748449002748 GTP/Mg2+ binding site [chemical binding]; other site 748449002749 G4 box; other site 748449002750 G5 box; other site 748449002751 G1 box; other site 748449002752 Switch I region; other site 748449002753 G2 box; other site 748449002754 G3 box; other site 748449002755 Switch II region; other site 748449002756 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 748449002757 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 748449002758 substrate binding site [chemical binding]; other site 748449002759 hexamer interface [polypeptide binding]; other site 748449002760 metal binding site [ion binding]; metal-binding site 748449002761 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 748449002762 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 748449002763 catalytic motif [active] 748449002764 Zn binding site [ion binding]; other site 748449002765 RibD C-terminal domain; Region: RibD_C; cl17279 748449002766 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 748449002767 Lumazine binding domain; Region: Lum_binding; pfam00677 748449002768 Lumazine binding domain; Region: Lum_binding; pfam00677 748449002769 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 748449002770 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 748449002771 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 748449002772 dimerization interface [polypeptide binding]; other site 748449002773 active site 748449002774 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 748449002775 homopentamer interface [polypeptide binding]; other site 748449002776 active site 748449002777 YmaF family; Region: YmaF; pfam12788 748449002778 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 748449002779 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 748449002780 minor groove reading motif; other site 748449002781 helix-hairpin-helix signature motif; other site 748449002782 substrate binding pocket [chemical binding]; other site 748449002783 active site 748449002784 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 748449002785 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 748449002786 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 748449002787 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 748449002788 Fe-S cluster binding site [ion binding]; other site 748449002789 active site 748449002790 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 748449002791 lipoprotein signal peptidase; Provisional; Region: PRK14787 748449002792 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 748449002793 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 748449002794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748449002795 RNA binding surface [nucleotide binding]; other site 748449002796 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 748449002797 active site 748449002798 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 748449002799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748449002800 active site 748449002801 uracil transporter; Provisional; Region: PRK10720 748449002802 Domain of unknown function (DUF373); Region: DUF373; cl12079 748449002803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748449002804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449002805 ATP binding site [chemical binding]; other site 748449002806 Mg2+ binding site [ion binding]; other site 748449002807 G-X-G motif; other site 748449002808 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 748449002809 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748449002810 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748449002811 dihydroorotase; Validated; Region: pyrC; PRK09357 748449002812 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748449002813 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 748449002814 active site 748449002815 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 748449002816 active site 748449002817 dimer interface [polypeptide binding]; other site 748449002818 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 748449002819 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 748449002820 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 748449002821 catalytic site [active] 748449002822 subunit interface [polypeptide binding]; other site 748449002823 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 748449002824 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748449002825 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 748449002826 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 748449002827 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748449002828 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748449002829 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 748449002830 IMP binding site; other site 748449002831 dimer interface [polypeptide binding]; other site 748449002832 interdomain contacts; other site 748449002833 partial ornithine binding site; other site 748449002834 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 748449002835 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 748449002836 FAD binding pocket [chemical binding]; other site 748449002837 FAD binding motif [chemical binding]; other site 748449002838 phosphate binding motif [ion binding]; other site 748449002839 beta-alpha-beta structure motif; other site 748449002840 NAD binding pocket [chemical binding]; other site 748449002841 Iron coordination center [ion binding]; other site 748449002842 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 748449002843 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 748449002844 heterodimer interface [polypeptide binding]; other site 748449002845 active site 748449002846 FMN binding site [chemical binding]; other site 748449002847 homodimer interface [polypeptide binding]; other site 748449002848 substrate binding site [chemical binding]; other site 748449002849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748449002850 active site 748449002851 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449002852 Zn2+ binding site [ion binding]; other site 748449002853 Mg2+ binding site [ion binding]; other site 748449002854 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 748449002855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449002856 Zn2+ binding site [ion binding]; other site 748449002857 Mg2+ binding site [ion binding]; other site 748449002858 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 748449002859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748449002860 Coenzyme A binding pocket [chemical binding]; other site 748449002861 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 748449002862 Domain of unknown function (DUF814); Region: DUF814; pfam05670 748449002863 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 748449002864 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 748449002865 dimer interface [polypeptide binding]; other site 748449002866 ADP-ribose binding site [chemical binding]; other site 748449002867 active site 748449002868 nudix motif; other site 748449002869 metal binding site [ion binding]; metal-binding site 748449002870 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 748449002871 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 748449002872 GAF domain; Region: GAF_3; pfam13492 748449002873 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 748449002874 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748449002875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748449002876 metal binding site [ion binding]; metal-binding site 748449002877 active site 748449002878 I-site; other site 748449002879 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 748449002880 active site 748449002881 metal binding site [ion binding]; metal-binding site 748449002882 homotetramer interface [polypeptide binding]; other site 748449002883 putative pseudouridylate synthase; Provisional; Region: PRK14554 748449002884 TruB family pseudouridylate synthase (N terminal domain); Region: TruB_N; pfam01509 748449002885 MoxR-like ATPases [General function prediction only]; Region: COG0714 748449002886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449002887 Walker A motif; other site 748449002888 ATP binding site [chemical binding]; other site 748449002889 Walker B motif; other site 748449002890 arginine finger; other site 748449002891 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 748449002892 Protein of unknown function DUF58; Region: DUF58; pfam01882 748449002893 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748449002894 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748449002895 Walker A/P-loop; other site 748449002896 ATP binding site [chemical binding]; other site 748449002897 Q-loop/lid; other site 748449002898 ABC transporter signature motif; other site 748449002899 Walker B; other site 748449002900 D-loop; other site 748449002901 H-loop/switch region; other site 748449002902 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 748449002903 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748449002904 FtsX-like permease family; Region: FtsX; pfam02687 748449002905 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 748449002906 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748449002907 FtsX-like permease family; Region: FtsX; pfam02687 748449002908 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 748449002909 4-alpha-glucanotransferase; Provisional; Region: PRK14508 748449002910 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142 748449002911 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748449002912 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 748449002913 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748449002914 active site 748449002915 catalytic tetrad [active] 748449002916 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748449002917 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 748449002918 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 748449002919 dimer interface [polypeptide binding]; other site 748449002920 active site residues [active] 748449002921 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 748449002922 hypothetical protein; Provisional; Region: PRK13665 748449002923 Predicted membrane protein [Function unknown]; Region: COG2323 748449002924 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748449002925 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 748449002926 GSH binding site [chemical binding]; other site 748449002927 catalytic residues [active] 748449002928 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 748449002929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449002930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449002931 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 748449002932 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 748449002933 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 748449002934 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 748449002935 Archaeal protein of unknown function (DUF911); Region: DUF911; pfam06023 748449002936 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A; cl17680 748449002937 Predicted transcriptional regulator [Transcription]; Region: COG2378 748449002938 WYL domain; Region: WYL; pfam13280 748449002939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 748449002940 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 748449002941 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 748449002942 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 748449002943 CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905 748449002944 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 748449002945 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 748449002946 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 748449002947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449002948 FeS/SAM binding site; other site 748449002949 TRAM domain; Region: TRAM; pfam01938 748449002950 Protein of unknown function (DUF964); Region: DUF964; pfam06133 748449002951 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 748449002952 MutS domain I; Region: MutS_I; pfam01624 748449002953 MutS domain II; Region: MutS_II; pfam05188 748449002954 MutS domain III; Region: MutS_III; pfam05192 748449002955 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 748449002956 Walker A/P-loop; other site 748449002957 ATP binding site [chemical binding]; other site 748449002958 Q-loop/lid; other site 748449002959 ABC transporter signature motif; other site 748449002960 Walker B; other site 748449002961 D-loop; other site 748449002962 H-loop/switch region; other site 748449002963 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 748449002964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449002965 ATP binding site [chemical binding]; other site 748449002966 Mg2+ binding site [ion binding]; other site 748449002967 G-X-G motif; other site 748449002968 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 748449002969 ATP binding site [chemical binding]; other site 748449002970 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 748449002971 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 748449002972 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 748449002973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 748449002974 stage V sporulation protein K; Region: spore_V_K; TIGR02881 748449002975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449002976 Walker A motif; other site 748449002977 ATP binding site [chemical binding]; other site 748449002978 Walker B motif; other site 748449002979 arginine finger; other site 748449002980 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 748449002981 G1 box; other site 748449002982 GTP/Mg2+ binding site [chemical binding]; other site 748449002983 G2 box; other site 748449002984 Switch I region; other site 748449002985 G3 box; other site 748449002986 Switch II region; other site 748449002987 G4 box; other site 748449002988 G5 box; other site 748449002989 bacterial Hfq-like; Region: Hfq; cd01716 748449002990 hexamer interface [polypeptide binding]; other site 748449002991 Sm1 motif; other site 748449002992 RNA binding site [nucleotide binding]; other site 748449002993 Sm2 motif; other site 748449002994 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 748449002995 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 748449002996 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 748449002997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449002998 binding surface 748449002999 Tetratricopeptide repeat; Region: TPR_16; pfam13432 748449003000 TPR motif; other site 748449003001 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 748449003002 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 748449003003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449003004 ATP binding site [chemical binding]; other site 748449003005 Mg2+ binding site [ion binding]; other site 748449003006 G-X-G motif; other site 748449003007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 748449003008 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 748449003009 LytB protein; Region: LYTB; cl00507 748449003010 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 748449003011 RNA binding site [nucleotide binding]; other site 748449003012 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 748449003013 RNA binding site [nucleotide binding]; other site 748449003014 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 748449003015 RNA binding site [nucleotide binding]; other site 748449003016 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 748449003017 RNA binding site [nucleotide binding]; other site 748449003018 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 748449003019 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 748449003020 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 748449003021 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 748449003022 active site 748449003023 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 748449003024 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 748449003025 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 748449003026 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 748449003027 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 748449003028 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 748449003029 dockerin binding interface; other site 748449003030 S-layer homology domain; Region: SLH; pfam00395 748449003031 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748449003032 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 748449003033 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 748449003034 dimer interface [polypeptide binding]; other site 748449003035 motif 1; other site 748449003036 active site 748449003037 motif 2; other site 748449003038 motif 3; other site 748449003039 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 748449003040 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 748449003041 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 748449003042 histidinol dehydrogenase; Region: hisD; TIGR00069 748449003043 NAD binding site [chemical binding]; other site 748449003044 dimerization interface [polypeptide binding]; other site 748449003045 product binding site; other site 748449003046 substrate binding site [chemical binding]; other site 748449003047 zinc binding site [ion binding]; other site 748449003048 catalytic residues [active] 748449003049 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 748449003050 putative active site pocket [active] 748449003051 4-fold oligomerization interface [polypeptide binding]; other site 748449003052 metal binding residues [ion binding]; metal-binding site 748449003053 3-fold/trimer interface [polypeptide binding]; other site 748449003054 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 748449003055 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 748449003056 putative active site [active] 748449003057 oxyanion strand; other site 748449003058 catalytic triad [active] 748449003059 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 748449003060 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 748449003061 catalytic residues [active] 748449003062 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 748449003063 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 748449003064 substrate binding site [chemical binding]; other site 748449003065 glutamase interaction surface [polypeptide binding]; other site 748449003066 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 748449003067 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 748449003068 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 748449003069 metal binding site [ion binding]; metal-binding site 748449003070 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748449003071 active site 748449003072 DNA binding site [nucleotide binding] 748449003073 Int/Topo IB signature motif; other site 748449003074 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 748449003075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449003076 Zn2+ binding site [ion binding]; other site 748449003077 Mg2+ binding site [ion binding]; other site 748449003078 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 748449003079 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 748449003080 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 748449003081 putative binding surface; other site 748449003082 active site 748449003083 P2 response regulator binding domain; Region: P2; pfam07194 748449003084 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 748449003085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449003086 ATP binding site [chemical binding]; other site 748449003087 Mg2+ binding site [ion binding]; other site 748449003088 G-X-G motif; other site 748449003089 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 748449003090 Response regulator receiver domain; Region: Response_reg; pfam00072 748449003091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748449003092 active site 748449003093 phosphorylation site [posttranslational modification] 748449003094 intermolecular recognition site; other site 748449003095 dimerization interface [polypeptide binding]; other site 748449003096 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 748449003097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748449003098 active site 748449003099 phosphorylation site [posttranslational modification] 748449003100 intermolecular recognition site; other site 748449003101 dimerization interface [polypeptide binding]; other site 748449003102 CheB methylesterase; Region: CheB_methylest; pfam01339 748449003103 DNA gyrase subunit A; Validated; Region: PRK05560 748449003104 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 748449003105 CAP-like domain; other site 748449003106 active site 748449003107 primary dimer interface [polypeptide binding]; other site 748449003108 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748449003109 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748449003110 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 748449003111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449003112 Mg2+ binding site [ion binding]; other site 748449003113 G-X-G motif; other site 748449003114 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 748449003115 anchoring element; other site 748449003116 dimer interface [polypeptide binding]; other site 748449003117 ATP binding site [chemical binding]; other site 748449003118 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 748449003119 active site 748449003120 putative metal-binding site [ion binding]; other site 748449003121 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 748449003122 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 748449003123 hypothetical protein; Provisional; Region: PRK08317 748449003124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449003125 S-adenosylmethionine binding site [chemical binding]; other site 748449003126 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449003127 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449003128 putative active site [active] 748449003129 putative NTP binding site [chemical binding]; other site 748449003130 putative nucleic acid binding site [nucleotide binding]; other site 748449003131 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 748449003132 Fic family protein [Function unknown]; Region: COG3177 748449003133 Fic/DOC family; Region: Fic; pfam02661 748449003134 Fic family protein [Function unknown]; Region: COG3177 748449003135 Fic/DOC family; Region: Fic; pfam02661 748449003136 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 748449003137 active site 748449003138 NTP binding site [chemical binding]; other site 748449003139 metal binding triad [ion binding]; metal-binding site 748449003140 antibiotic binding site [chemical binding]; other site 748449003141 Uncharacterized conserved protein [Function unknown]; Region: COG2361 748449003142 Methyltransferase domain; Region: Methyltransf_23; pfam13489 748449003143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449003144 S-adenosylmethionine binding site [chemical binding]; other site 748449003145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748449003146 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 748449003147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748449003148 Coenzyme A binding pocket [chemical binding]; other site 748449003149 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 748449003150 dinuclear metal binding motif [ion binding]; other site 748449003151 Predicted membrane protein [Function unknown]; Region: COG2323 748449003152 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 748449003153 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 748449003154 dimer interface [polypeptide binding]; other site 748449003155 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748449003156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449003157 dimerization interface [polypeptide binding]; other site 748449003158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449003159 dimer interface [polypeptide binding]; other site 748449003160 putative CheW interface [polypeptide binding]; other site 748449003161 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 748449003162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449003163 S-adenosylmethionine binding site [chemical binding]; other site 748449003164 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 748449003165 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 748449003166 putative dimer interface [polypeptide binding]; other site 748449003167 putative anticodon binding site; other site 748449003168 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 748449003169 homodimer interface [polypeptide binding]; other site 748449003170 motif 1; other site 748449003171 motif 2; other site 748449003172 active site 748449003173 motif 3; other site 748449003174 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 748449003175 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 748449003176 putative catalytic cysteine [active] 748449003177 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 748449003178 putative active site [active] 748449003179 metal binding site [ion binding]; metal-binding site 748449003180 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 748449003181 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 748449003182 TrkA-C domain; Region: TrkA_C; pfam02080 748449003183 TrkA-C domain; Region: TrkA_C; pfam02080 748449003184 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 748449003185 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 748449003186 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 748449003187 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 748449003188 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748449003189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449003190 S-adenosylmethionine binding site [chemical binding]; other site 748449003191 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449003192 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 748449003193 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449003194 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 748449003195 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449003196 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 748449003197 glycerate kinase; Region: TIGR00045 748449003198 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 748449003199 fructuronate transporter; Provisional; Region: PRK10034; cl15264 748449003200 Spore germination protein; Region: Spore_permease; cl17796 748449003201 4-alpha-glucanotransferase; Provisional; Region: PRK14508 748449003202 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 748449003203 homotrimer interaction site [polypeptide binding]; other site 748449003204 putative active site [active] 748449003205 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 748449003206 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 748449003207 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748449003208 catalytic residue [active] 748449003209 probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316 748449003210 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748449003211 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748449003212 peptidase; Reviewed; Region: PRK13004 748449003213 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 748449003214 putative metal binding site [ion binding]; other site 748449003215 putative dimer interface [polypeptide binding]; other site 748449003216 xanthine permease; Region: pbuX; TIGR03173 748449003217 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 748449003218 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 748449003219 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 748449003220 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 748449003221 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 748449003222 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 748449003223 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748449003224 catalytic loop [active] 748449003225 iron binding site [ion binding]; other site 748449003226 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 748449003227 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 748449003228 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 748449003229 active site 748449003230 putative substrate binding pocket [chemical binding]; other site 748449003231 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 748449003232 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748449003233 active site 748449003234 FAD binding domain; Region: FAD_binding_4; pfam01565 748449003235 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 748449003236 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 748449003237 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 748449003238 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 748449003239 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 748449003240 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 748449003241 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 748449003242 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 748449003243 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 748449003244 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 748449003245 phosphate binding site [ion binding]; other site 748449003246 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748449003247 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748449003248 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 748449003249 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748449003250 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 748449003251 active site 748449003252 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 748449003253 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 748449003254 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 748449003255 Ligand binding site; other site 748449003256 metal-binding site 748449003257 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 748449003258 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 748449003259 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 748449003260 XdhC Rossmann domain; Region: XdhC_C; pfam13478 748449003261 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 748449003262 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 748449003263 putative MPT binding site; other site 748449003264 phenylhydantoinase; Validated; Region: PRK08323 748449003265 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748449003266 active site 748449003267 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 748449003268 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 748449003269 FAD binding pocket [chemical binding]; other site 748449003270 FAD binding motif [chemical binding]; other site 748449003271 phosphate binding motif [ion binding]; other site 748449003272 beta-alpha-beta structure motif; other site 748449003273 NAD binding pocket [chemical binding]; other site 748449003274 Iron coordination center [ion binding]; other site 748449003275 putative oxidoreductase; Provisional; Region: PRK12831 748449003276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449003277 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449003278 carbamate kinase; Reviewed; Region: PRK12686 748449003279 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 748449003280 putative substrate binding site [chemical binding]; other site 748449003281 nucleotide binding site [chemical binding]; other site 748449003282 nucleotide binding site [chemical binding]; other site 748449003283 homodimer interface [polypeptide binding]; other site 748449003284 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 748449003285 Ligand binding site; other site 748449003286 metal-binding site 748449003287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 748449003288 YheO-like PAS domain; Region: PAS_6; pfam08348 748449003289 HTH domain; Region: HTH_22; pfam13309 748449003290 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748449003291 metal binding site 2 [ion binding]; metal-binding site 748449003292 putative DNA binding helix; other site 748449003293 metal binding site 1 [ion binding]; metal-binding site 748449003294 dimer interface [polypeptide binding]; other site 748449003295 structural Zn2+ binding site [ion binding]; other site 748449003296 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 748449003297 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 748449003298 Chromate transporter; Region: Chromate_transp; pfam02417 748449003299 Uncharacterized conserved protein [Function unknown]; Region: COG2014 748449003300 Domain of unknown function (DUF364); Region: DUF364; pfam04016 748449003301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748449003302 dimerization interface [polypeptide binding]; other site 748449003303 putative DNA binding site [nucleotide binding]; other site 748449003304 putative Zn2+ binding site [ion binding]; other site 748449003305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449003306 DNA binding residues [nucleotide binding] 748449003307 Late competence development protein ComFB; Region: ComFB; pfam10719 748449003308 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 748449003309 DNA-binding site [nucleotide binding]; DNA binding site 748449003310 RNA-binding motif; other site 748449003311 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 748449003312 DNA-binding site [nucleotide binding]; DNA binding site 748449003313 RNA-binding motif; other site 748449003314 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 748449003315 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 748449003316 Family description; Region: UvrD_C_2; pfam13538 748449003317 Methyltransferase domain; Region: Methyltransf_26; pfam13659 748449003318 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 748449003319 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 748449003320 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 748449003321 Part of AAA domain; Region: AAA_19; pfam13245 748449003322 putative recombination protein RecB; Provisional; Region: PRK13909 748449003323 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 748449003324 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 748449003325 Dynamin family; Region: Dynamin_N; pfam00350 748449003326 G1 box; other site 748449003327 GTP/Mg2+ binding site [chemical binding]; other site 748449003328 G2 box; other site 748449003329 Switch I region; other site 748449003330 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 748449003331 G3 box; other site 748449003332 Switch II region; other site 748449003333 GTP/Mg2+ binding site [chemical binding]; other site 748449003334 G4 box; other site 748449003335 G5 box; other site 748449003336 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 748449003337 GTP/Mg2+ binding site [chemical binding]; other site 748449003338 Dynamin family; Region: Dynamin_N; pfam00350 748449003339 G1 box; other site 748449003340 G2 box; other site 748449003341 Switch I region; other site 748449003342 G3 box; other site 748449003343 Switch II region; other site 748449003344 G4 box; other site 748449003345 G5 box; other site 748449003346 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 748449003347 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 748449003348 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 748449003349 Methyltransferase domain; Region: Methyltransf_26; pfam13659 748449003350 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 748449003351 TIGR02687 family protein; Region: TIGR02687 748449003352 PglZ domain; Region: PglZ; pfam08665 748449003353 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 748449003354 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 748449003355 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 748449003356 ligand binding site [chemical binding]; other site 748449003357 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 748449003358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449003359 ATP binding site [chemical binding]; other site 748449003360 putative Mg++ binding site [ion binding]; other site 748449003361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449003362 nucleotide binding region [chemical binding]; other site 748449003363 ATP-binding site [chemical binding]; other site 748449003364 Restriction endonuclease; Region: Mrr_cat; pfam04471 748449003365 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 748449003366 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 748449003367 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449003368 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449003369 putative active site [active] 748449003370 putative NTP binding site [chemical binding]; other site 748449003371 putative nucleic acid binding site [nucleotide binding]; other site 748449003372 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449003373 Protein of unknown function (DUF805); Region: DUF805; pfam05656 748449003374 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 748449003375 Double zinc ribbon; Region: DZR; pfam12773 748449003376 Double zinc ribbon; Region: DZR; pfam12773 748449003377 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 748449003378 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 748449003379 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 748449003380 Uncharacterized conserved protein [Function unknown]; Region: COG4715 748449003381 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 748449003382 AAA domain; Region: AAA_30; pfam13604 748449003383 Family description; Region: UvrD_C_2; pfam13538 748449003384 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 748449003385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449003386 ATP binding site [chemical binding]; other site 748449003387 putative Mg++ binding site [ion binding]; other site 748449003388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449003389 nucleotide binding region [chemical binding]; other site 748449003390 ATP-binding site [chemical binding]; other site 748449003391 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 748449003392 HRDC domain; Region: HRDC; pfam00570 748449003393 Uncharacterized conserved protein [Function unknown]; Region: COG3339 748449003394 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 748449003395 active site residue [active] 748449003396 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 748449003397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 748449003398 Lamin Tail Domain; Region: LTD; pfam00932 748449003399 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 748449003400 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 748449003401 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 748449003402 ATP binding site [chemical binding]; other site 748449003403 Mg++ binding site [ion binding]; other site 748449003404 motif III; other site 748449003405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449003406 nucleotide binding region [chemical binding]; other site 748449003407 ATP-binding site [chemical binding]; other site 748449003408 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 748449003409 RNA binding site [nucleotide binding]; other site 748449003410 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 748449003411 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 748449003412 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 748449003413 active site 748449003414 metal binding site [ion binding]; metal-binding site 748449003415 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 748449003416 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449003417 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 748449003418 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 748449003419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748449003420 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 748449003421 Soluble P-type ATPase [General function prediction only]; Region: COG4087 748449003422 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 748449003423 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 748449003424 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 748449003425 NAD(P) binding site [chemical binding]; other site 748449003426 LDH/MDH dimer interface [polypeptide binding]; other site 748449003427 substrate binding site [chemical binding]; other site 748449003428 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449003429 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449003430 putative active site [active] 748449003431 putative NTP binding site [chemical binding]; other site 748449003432 putative nucleic acid binding site [nucleotide binding]; other site 748449003433 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449003434 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 748449003435 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 748449003436 dimer interface [polypeptide binding]; other site 748449003437 active site 748449003438 metal binding site [ion binding]; metal-binding site 748449003439 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 748449003440 trimer interface [polypeptide binding]; other site 748449003441 putative Zn binding site [ion binding]; other site 748449003442 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 748449003443 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 748449003444 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 748449003445 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 748449003446 aspartate aminotransferase; Provisional; Region: PRK06290 748449003447 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748449003448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449003449 homodimer interface [polypeptide binding]; other site 748449003450 catalytic residue [active] 748449003451 HEAT repeats; Region: HEAT_2; pfam13646 748449003452 HEAT repeats; Region: HEAT_2; pfam13646 748449003453 glycogen synthase; Provisional; Region: glgA; PRK00654 748449003454 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 748449003455 ADP-binding pocket [chemical binding]; other site 748449003456 homodimer interface [polypeptide binding]; other site 748449003457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 748449003458 Uncharacterized conserved protein [Function unknown]; Region: COG1543 748449003459 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 748449003460 active site 748449003461 substrate binding site [chemical binding]; other site 748449003462 catalytic site [active] 748449003463 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 748449003464 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 748449003465 putative homodimer interface [polypeptide binding]; other site 748449003466 putative active site pocket [active] 748449003467 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 748449003468 Predicted membrane protein [Function unknown]; Region: COG2323 748449003469 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 748449003470 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 748449003471 HTH domain; Region: HTH_11; pfam08279 748449003472 3H domain; Region: 3H; pfam02829 748449003473 Quinolinate synthetase A protein; Region: NadA; pfam02445 748449003474 L-aspartate oxidase; Provisional; Region: PRK06175 748449003475 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 748449003476 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 748449003477 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 748449003478 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 748449003479 dimerization interface [polypeptide binding]; other site 748449003480 active site 748449003481 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 748449003482 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 748449003483 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 748449003484 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 748449003485 ligand binding site; other site 748449003486 oligomer interface; other site 748449003487 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 748449003488 dimer interface [polypeptide binding]; other site 748449003489 N-terminal domain interface [polypeptide binding]; other site 748449003490 sulfate 1 binding site; other site 748449003491 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 748449003492 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 748449003493 ligand binding site; other site 748449003494 oligomer interface; other site 748449003495 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 748449003496 dimer interface [polypeptide binding]; other site 748449003497 N-terminal domain interface [polypeptide binding]; other site 748449003498 sulfate 1 binding site; other site 748449003499 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 748449003500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748449003501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449003502 homodimer interface [polypeptide binding]; other site 748449003503 catalytic residue [active] 748449003504 Predicted membrane protein [Function unknown]; Region: COG2323 748449003505 Cache domain; Region: Cache_1; pfam02743 748449003506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449003507 dimerization interface [polypeptide binding]; other site 748449003508 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449003509 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449003510 dimer interface [polypeptide binding]; other site 748449003511 putative CheW interface [polypeptide binding]; other site 748449003512 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748449003513 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 748449003514 Clp amino terminal domain; Region: Clp_N; pfam02861 748449003515 Clp amino terminal domain; Region: Clp_N; pfam02861 748449003516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449003517 Walker A motif; other site 748449003518 ATP binding site [chemical binding]; other site 748449003519 Walker B motif; other site 748449003520 arginine finger; other site 748449003521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449003522 Walker A motif; other site 748449003523 ATP binding site [chemical binding]; other site 748449003524 Walker B motif; other site 748449003525 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 748449003526 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 748449003527 dinuclear metal binding motif [ion binding]; other site 748449003528 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 748449003529 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 748449003530 active site residue [active] 748449003531 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 748449003532 active site residue [active] 748449003533 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449003534 putative CheW interface [polypeptide binding]; other site 748449003535 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 748449003536 active site 748449003537 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748449003538 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 748449003539 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 748449003540 CPxP motif; other site 748449003541 putative inner membrane protein; Provisional; Region: PRK11099 748449003542 CGGC domain; Region: CGGC; pfam08821 748449003543 CGGC domain; Region: CGGC; cl02356 748449003544 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 748449003545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449003546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449003547 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 748449003548 Cysteine-rich domain; Region: CCG; pfam02754 748449003549 Cysteine-rich domain; Region: CCG; pfam02754 748449003550 Uncharacterized conserved protein [Function unknown]; Region: COG0398 748449003551 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 748449003552 hypothetical protein; Provisional; Region: PRK11622 748449003553 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 748449003554 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 748449003555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449003556 dimer interface [polypeptide binding]; other site 748449003557 conserved gate region; other site 748449003558 putative PBP binding loops; other site 748449003559 ABC-ATPase subunit interface; other site 748449003560 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 748449003561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449003562 dimer interface [polypeptide binding]; other site 748449003563 conserved gate region; other site 748449003564 putative PBP binding loops; other site 748449003565 ABC-ATPase subunit interface; other site 748449003566 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 748449003567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449003568 Walker A/P-loop; other site 748449003569 ATP binding site [chemical binding]; other site 748449003570 Q-loop/lid; other site 748449003571 ABC transporter signature motif; other site 748449003572 Walker B; other site 748449003573 D-loop; other site 748449003574 H-loop/switch region; other site 748449003575 TOBE domain; Region: TOBE_2; pfam08402 748449003576 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 748449003577 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 748449003578 Probable Catalytic site; other site 748449003579 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 748449003580 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 748449003581 Phosphotransferase enzyme family; Region: APH; pfam01636 748449003582 active site 748449003583 ATP binding site [chemical binding]; other site 748449003584 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 748449003585 active site 748449003586 ATP binding site [chemical binding]; other site 748449003587 Propionate catabolism activator; Region: PrpR_N; pfam06506 748449003588 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 748449003589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748449003590 putative active site [active] 748449003591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449003592 Walker A motif; other site 748449003593 ATP binding site [chemical binding]; other site 748449003594 Walker B motif; other site 748449003595 arginine finger; other site 748449003596 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 748449003597 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 748449003598 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 748449003599 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 748449003600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 748449003601 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 748449003602 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 748449003603 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 748449003604 RHS Repeat; Region: RHS_repeat; pfam05593 748449003605 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 748449003606 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 748449003607 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 748449003608 RHS Repeat; Region: RHS_repeat; pfam05593 748449003609 RHS Repeat; Region: RHS_repeat; pfam05593 748449003610 RHS Repeat; Region: RHS_repeat; pfam05593 748449003611 RHS Repeat; Region: RHS_repeat; pfam05593 748449003612 RHS protein; Region: RHS; pfam03527 748449003613 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 748449003614 RHS Repeat; Region: RHS_repeat; cl11982 748449003615 RHS Repeat; Region: RHS_repeat; pfam05593 748449003616 RHS Repeat; Region: RHS_repeat; cl11982 748449003617 RHS protein; Region: RHS; pfam03527 748449003618 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 748449003619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748449003620 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748449003621 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748449003622 Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995 748449003623 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 748449003624 hybrid cluster protein; Provisional; Region: PRK05290 748449003625 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 748449003626 Part of AAA domain; Region: AAA_19; pfam13245 748449003627 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 748449003628 active site 748449003629 multimer interface [polypeptide binding]; other site 748449003630 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 748449003631 Malic enzyme, N-terminal domain; Region: malic; pfam00390 748449003632 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 748449003633 putative NAD(P) binding site [chemical binding]; other site 748449003634 ribosomal protein L28; Region: L28; TIGR00009 748449003635 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 748449003636 Asp23 family; Region: Asp23; pfam03780 748449003637 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 748449003638 DAK2 domain; Region: Dak2; pfam02734 748449003639 EDD domain protein, DegV family; Region: DegV; TIGR00762 748449003640 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748449003641 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 748449003642 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 748449003643 generic binding surface II; other site 748449003644 ssDNA binding site; other site 748449003645 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449003646 ATP binding site [chemical binding]; other site 748449003647 putative Mg++ binding site [ion binding]; other site 748449003648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449003649 nucleotide binding region [chemical binding]; other site 748449003650 ATP-binding site [chemical binding]; other site 748449003651 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 748449003652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449003653 S-adenosylmethionine binding site [chemical binding]; other site 748449003654 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 748449003655 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 748449003656 active site 748449003657 (T/H)XGH motif; other site 748449003658 Nucleoside recognition; Region: Gate; pfam07670 748449003659 Nucleoside recognition; Region: Gate; pfam07670 748449003660 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 748449003661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449003662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449003663 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 748449003664 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 748449003665 active site residue [active] 748449003666 Putative amidase domain; Region: Amidase_6; pfam12671 748449003667 Predicted permease [General function prediction only]; Region: COG2056 748449003668 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 748449003669 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 748449003670 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 748449003671 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 748449003672 4Fe-4S binding domain; Region: Fer4_5; pfam12801 748449003673 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748449003674 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748449003675 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748449003676 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 748449003677 catalytic residues [active] 748449003678 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 748449003679 carbohydrate binding site [chemical binding]; other site 748449003680 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 748449003681 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 748449003682 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 748449003683 active site 748449003684 catalytic site [active] 748449003685 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 748449003686 Cell division protein FtsA; Region: FtsA; smart00842 748449003687 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748449003688 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 748449003689 Hemerythrin-like domain; Region: Hr-like; cd12108 748449003690 Fe binding site [ion binding]; other site 748449003691 NifU-like domain; Region: NifU; pfam01106 748449003692 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 748449003693 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748449003694 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 748449003695 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 748449003696 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748449003697 metal-binding site [ion binding] 748449003698 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748449003699 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748449003700 ligand binding site [chemical binding]; other site 748449003701 flexible hinge region; other site 748449003702 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 748449003703 putative switch regulator; other site 748449003704 non-specific DNA interactions [nucleotide binding]; other site 748449003705 DNA binding site [nucleotide binding] 748449003706 sequence specific DNA binding site [nucleotide binding]; other site 748449003707 putative cAMP binding site [chemical binding]; other site 748449003708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748449003709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748449003710 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 748449003711 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 748449003712 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 748449003713 HlyD family secretion protein; Region: HlyD_3; pfam13437 748449003714 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 748449003715 Protein export membrane protein; Region: SecD_SecF; cl14618 748449003716 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 748449003717 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 748449003718 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 748449003719 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 748449003720 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 748449003721 ACS interaction site; other site 748449003722 CODH interaction site; other site 748449003723 cubane metal cluster (B-cluster) [ion binding]; other site 748449003724 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 748449003725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449003726 dimer interface [polypeptide binding]; other site 748449003727 putative CheW interface [polypeptide binding]; other site 748449003728 HPP family; Region: HPP; pfam04982 748449003729 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 748449003730 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 748449003731 GTP binding site; other site 748449003732 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 748449003733 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 748449003734 [4Fe-4S] binding site [ion binding]; other site 748449003735 molybdopterin cofactor binding site; other site 748449003736 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 748449003737 molybdopterin cofactor binding site; other site 748449003738 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 748449003739 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748449003740 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 748449003741 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449003742 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 748449003743 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748449003744 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 748449003745 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 748449003746 dimer interface [polypeptide binding]; other site 748449003747 putative functional site; other site 748449003748 putative MPT binding site; other site 748449003749 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 748449003750 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 748449003751 dimer interface [polypeptide binding]; other site 748449003752 putative functional site; other site 748449003753 putative MPT binding site; other site 748449003754 PBP superfamily domain; Region: PBP_like; pfam12727 748449003755 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 748449003756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449003757 FeS/SAM binding site; other site 748449003758 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 748449003759 molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499 748449003760 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cd00528 748449003761 trimer interface [polypeptide binding]; other site 748449003762 dimer interface [polypeptide binding]; other site 748449003763 putative active site [active] 748449003764 MOSC domain; Region: MOSC; pfam03473 748449003765 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 748449003766 MPT binding site; other site 748449003767 trimer interface [polypeptide binding]; other site 748449003768 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 748449003769 Walker A motif; other site 748449003770 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 748449003771 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 748449003772 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748449003773 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 748449003774 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 748449003775 FAD binding pocket [chemical binding]; other site 748449003776 FAD binding motif [chemical binding]; other site 748449003777 phosphate binding motif [ion binding]; other site 748449003778 beta-alpha-beta structure motif; other site 748449003779 NAD binding pocket [chemical binding]; other site 748449003780 Iron coordination center [ion binding]; other site 748449003781 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 748449003782 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 748449003783 4Fe-4S binding domain; Region: Fer4_6; pfam12837 748449003784 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748449003785 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748449003786 ligand binding site [chemical binding]; other site 748449003787 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 748449003788 putative switch regulator; other site 748449003789 non-specific DNA interactions [nucleotide binding]; other site 748449003790 DNA binding site [nucleotide binding] 748449003791 sequence specific DNA binding site [nucleotide binding]; other site 748449003792 putative cAMP binding site [chemical binding]; other site 748449003793 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 748449003794 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 748449003795 tRNA; other site 748449003796 putative tRNA binding site [nucleotide binding]; other site 748449003797 putative NADP binding site [chemical binding]; other site 748449003798 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 748449003799 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 748449003800 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 748449003801 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 748449003802 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 748449003803 domain interfaces; other site 748449003804 active site 748449003805 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 748449003806 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 748449003807 active site 748449003808 SAM binding site [chemical binding]; other site 748449003809 homodimer interface [polypeptide binding]; other site 748449003810 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 748449003811 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 748449003812 active site 748449003813 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 748449003814 dimer interface [polypeptide binding]; other site 748449003815 active site 748449003816 Schiff base residues; other site 748449003817 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 748449003818 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 748449003819 inhibitor-cofactor binding pocket; inhibition site 748449003820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449003821 catalytic residue [active] 748449003822 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 748449003823 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 748449003824 putative active site [active] 748449003825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449003826 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748449003827 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748449003828 ligand binding site [chemical binding]; other site 748449003829 flexible hinge region; other site 748449003830 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 748449003831 putative switch regulator; other site 748449003832 non-specific DNA interactions [nucleotide binding]; other site 748449003833 DNA binding site [nucleotide binding] 748449003834 sequence specific DNA binding site [nucleotide binding]; other site 748449003835 putative cAMP binding site [chemical binding]; other site 748449003836 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 748449003837 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 748449003838 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 748449003839 Catalytic domain of Protein Kinases; Region: PKc; cd00180 748449003840 active site 748449003841 ATP binding site [chemical binding]; other site 748449003842 substrate binding site [chemical binding]; other site 748449003843 activation loop (A-loop); other site 748449003844 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 748449003845 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 748449003846 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 748449003847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 748449003848 NAD(P) binding site [chemical binding]; other site 748449003849 active site 748449003850 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748449003851 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748449003852 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 748449003853 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 748449003854 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 748449003855 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 748449003856 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 748449003857 dimerization interface [polypeptide binding]; other site 748449003858 putative ATP binding site [chemical binding]; other site 748449003859 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 748449003860 glycogen branching enzyme; Provisional; Region: PRK05402 748449003861 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 748449003862 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 748449003863 active site 748449003864 catalytic site [active] 748449003865 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 748449003866 PGAP1-like protein; Region: PGAP1; pfam07819 748449003867 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748449003868 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 748449003869 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 748449003870 putative active site [active] 748449003871 catalytic triad [active] 748449003872 putative dimer interface [polypeptide binding]; other site 748449003873 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 748449003874 Thiamine pyrophosphokinase; Region: TPK; cd07995 748449003875 active site 748449003876 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 748449003877 dimerization interface [polypeptide binding]; other site 748449003878 thiamine binding site [chemical binding]; other site 748449003879 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 748449003880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449003881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449003882 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 748449003883 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748449003884 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748449003885 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 748449003886 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 748449003887 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 748449003888 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 748449003889 catalytic residue [active] 748449003890 putative FPP diphosphate binding site; other site 748449003891 putative FPP binding hydrophobic cleft; other site 748449003892 dimer interface [polypeptide binding]; other site 748449003893 putative IPP diphosphate binding site; other site 748449003894 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 748449003895 thiS-thiF/thiG interaction site; other site 748449003896 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 748449003897 ThiS interaction site; other site 748449003898 putative active site [active] 748449003899 tetramer interface [polypeptide binding]; other site 748449003900 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 748449003901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449003902 FeS/SAM binding site; other site 748449003903 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 748449003904 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 748449003905 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 748449003906 ATP binding site [chemical binding]; other site 748449003907 substrate interface [chemical binding]; other site 748449003908 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 748449003909 thiamine phosphate binding site [chemical binding]; other site 748449003910 active site 748449003911 pyrophosphate binding site [ion binding]; other site 748449003912 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 748449003913 FAD binding site [chemical binding]; other site 748449003914 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 748449003915 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 748449003916 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 748449003917 substrate binding pocket [chemical binding]; other site 748449003918 dimer interface [polypeptide binding]; other site 748449003919 inhibitor binding site; inhibition site 748449003920 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 748449003921 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 748449003922 B12 binding site [chemical binding]; other site 748449003923 cobalt ligand [ion binding]; other site 748449003924 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 748449003925 Predicted transcriptional regulator [Transcription]; Region: COG4189 748449003926 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748449003927 putative DNA binding site [nucleotide binding]; other site 748449003928 dimerization interface [polypeptide binding]; other site 748449003929 putative Zn2+ binding site [ion binding]; other site 748449003930 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449003931 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748449003932 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449003933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 748449003934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449003935 dimer interface [polypeptide binding]; other site 748449003936 ABC-ATPase subunit interface; other site 748449003937 putative PBP binding loops; other site 748449003938 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449003939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449003940 dimer interface [polypeptide binding]; other site 748449003941 conserved gate region; other site 748449003942 putative PBP binding loops; other site 748449003943 ABC-ATPase subunit interface; other site 748449003944 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 748449003945 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 748449003946 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 748449003947 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 748449003948 active site 748449003949 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 748449003950 active site 748449003951 catalytic residues [active] 748449003952 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449003953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449003954 dimer interface [polypeptide binding]; other site 748449003955 conserved gate region; other site 748449003956 putative PBP binding loops; other site 748449003957 ABC-ATPase subunit interface; other site 748449003958 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449003959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449003960 dimer interface [polypeptide binding]; other site 748449003961 conserved gate region; other site 748449003962 putative PBP binding loops; other site 748449003963 ABC-ATPase subunit interface; other site 748449003964 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748449003965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748449003966 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449003967 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748449003968 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 748449003969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449003970 dimer interface [polypeptide binding]; other site 748449003971 conserved gate region; other site 748449003972 putative PBP binding loops; other site 748449003973 ABC-ATPase subunit interface; other site 748449003974 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449003975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449003976 dimer interface [polypeptide binding]; other site 748449003977 conserved gate region; other site 748449003978 putative PBP binding loops; other site 748449003979 ABC-ATPase subunit interface; other site 748449003980 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 748449003981 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 748449003982 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 748449003983 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 748449003984 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 748449003985 non-specific DNA interactions [nucleotide binding]; other site 748449003986 DNA binding site [nucleotide binding] 748449003987 sequence specific DNA binding site [nucleotide binding]; other site 748449003988 putative cAMP binding site [chemical binding]; other site 748449003989 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 748449003990 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748449003991 nucleotide binding site [chemical binding]; other site 748449003992 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748449003993 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 748449003994 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 748449003995 NAD binding site [chemical binding]; other site 748449003996 homodimer interface [polypeptide binding]; other site 748449003997 active site 748449003998 substrate binding site [chemical binding]; other site 748449003999 galactokinase; Provisional; Region: PRK05322 748449004000 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 748449004001 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 748449004002 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 748449004003 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 748449004004 active site 748449004005 catalytic residues [active] 748449004006 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 748449004007 Melibiase; Region: Melibiase; pfam02065 748449004008 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 748449004009 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 748449004010 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 748449004011 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 748449004012 CHASE2 domain; Region: CHASE2; pfam05226 748449004013 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 748449004014 cyclase homology domain; Region: CHD; cd07302 748449004015 nucleotidyl binding site; other site 748449004016 metal binding site [ion binding]; metal-binding site 748449004017 dimer interface [polypeptide binding]; other site 748449004018 FecR protein; Region: FecR; pfam04773 748449004019 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748449004020 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748449004021 ligand binding site [chemical binding]; other site 748449004022 flexible hinge region; other site 748449004023 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 748449004024 non-specific DNA interactions [nucleotide binding]; other site 748449004025 DNA binding site [nucleotide binding] 748449004026 sequence specific DNA binding site [nucleotide binding]; other site 748449004027 putative cAMP binding site [chemical binding]; other site 748449004028 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 748449004029 flagellar operon protein TIGR03826; Region: YvyF 748449004030 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 748449004031 Peptidase family U32; Region: Peptidase_U32; pfam01136 748449004032 Collagenase; Region: DUF3656; pfam12392 748449004033 Peptidase family U32; Region: Peptidase_U32; pfam01136 748449004034 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 748449004035 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748449004036 active site 748449004037 DNA binding site [nucleotide binding] 748449004038 Int/Topo IB signature motif; other site 748449004039 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 748449004040 stage V sporulation protein B; Region: spore_V_B; TIGR02900 748449004041 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 748449004042 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 748449004043 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 748449004044 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 748449004045 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 748449004046 homodimer interface [polypeptide binding]; other site 748449004047 substrate-cofactor binding pocket; other site 748449004048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449004049 catalytic residue [active] 748449004050 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 748449004051 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 748449004052 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 748449004053 Ligand Binding Site [chemical binding]; other site 748449004054 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 748449004055 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 748449004056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748449004057 catalytic residue [active] 748449004058 Domain of unknown function DUF77; Region: DUF77; pfam01910 748449004059 Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031 748449004060 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 748449004061 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 748449004062 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 748449004063 Domain of unknown function DUF20; Region: UPF0118; pfam01594 748449004064 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 748449004065 active site 748449004066 DNA polymerase IV; Validated; Region: PRK02406 748449004067 DNA binding site [nucleotide binding] 748449004068 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748449004069 FtsX-like permease family; Region: FtsX; pfam02687 748449004070 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748449004071 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748449004072 Walker A/P-loop; other site 748449004073 ATP binding site [chemical binding]; other site 748449004074 Q-loop/lid; other site 748449004075 ABC transporter signature motif; other site 748449004076 Walker B; other site 748449004077 D-loop; other site 748449004078 H-loop/switch region; other site 748449004079 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 748449004080 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748449004081 HlyD family secretion protein; Region: HlyD_3; pfam13437 748449004082 Outer membrane efflux protein; Region: OEP; pfam02321 748449004083 Outer membrane efflux protein; Region: OEP; pfam02321 748449004084 Outer membrane efflux protein; Region: OEP; pfam02321 748449004085 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 748449004086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748449004087 MarR family; Region: MarR; pfam01047 748449004088 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 748449004089 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748449004090 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 748449004091 Uncharacterized conserved protein [Function unknown]; Region: COG5663 748449004092 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 748449004093 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 748449004094 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449004095 FeS/SAM binding site; other site 748449004096 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 748449004097 active site 748449004098 homotetramer interface [polypeptide binding]; other site 748449004099 homodimer interface [polypeptide binding]; other site 748449004100 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 748449004101 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 748449004102 oligomer interface [polypeptide binding]; other site 748449004103 active site 748449004104 metal binding site [ion binding]; metal-binding site 748449004105 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 748449004106 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 748449004107 oligomer interface [polypeptide binding]; other site 748449004108 active site 748449004109 metal binding site [ion binding]; metal-binding site 748449004110 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 748449004111 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 748449004112 oligomer interface [polypeptide binding]; other site 748449004113 active site 748449004114 metal binding site [ion binding]; metal-binding site 748449004115 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 748449004116 Uncharacterized conserved protein [Function unknown]; Region: COG1615 748449004117 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 748449004118 metal ion-dependent adhesion site (MIDAS); other site 748449004119 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 748449004120 PrcB C-terminal; Region: PrcB_C; pfam14343 748449004121 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 748449004122 NodB motif; other site 748449004123 putative active site [active] 748449004124 putative catalytic site [active] 748449004125 Zn binding site [ion binding]; other site 748449004126 Predicted membrane protein [Function unknown]; Region: COG1971 748449004127 Domain of unknown function DUF; Region: DUF204; pfam02659 748449004128 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 748449004129 EDD domain protein, DegV family; Region: DegV; TIGR00762 748449004130 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748449004131 hypothetical protein; Validated; Region: PRK07682 748449004132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748449004133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449004134 homodimer interface [polypeptide binding]; other site 748449004135 catalytic residue [active] 748449004136 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 748449004137 AsnC family; Region: AsnC_trans_reg; pfam01037 748449004138 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 748449004139 active site 748449004140 DNA binding site [nucleotide binding] 748449004141 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 748449004142 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 748449004143 catalytic residues [active] 748449004144 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 748449004145 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 748449004146 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 748449004147 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 748449004148 active site 748449004149 dimer interface [polypeptide binding]; other site 748449004150 metal binding site [ion binding]; metal-binding site 748449004151 glutathione binding site [chemical binding]; other site 748449004152 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 748449004153 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 748449004154 N-acetyl-D-glucosamine binding site [chemical binding]; other site 748449004155 catalytic residue [active] 748449004156 Domain of unknown function (DUF378); Region: DUF378; cl00943 748449004157 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 748449004158 dimerization interface [polypeptide binding]; other site 748449004159 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 748449004160 Carbon starvation protein CstA; Region: CstA; pfam02554 748449004161 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 748449004162 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 748449004163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748449004164 active site 748449004165 phosphorylation site [posttranslational modification] 748449004166 intermolecular recognition site; other site 748449004167 dimerization interface [polypeptide binding]; other site 748449004168 LytTr DNA-binding domain; Region: LytTR; pfam04397 748449004169 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 748449004170 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 748449004171 Histidine kinase; Region: His_kinase; pfam06580 748449004172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449004173 ATP binding site [chemical binding]; other site 748449004174 Mg2+ binding site [ion binding]; other site 748449004175 G-X-G motif; other site 748449004176 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 748449004177 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 748449004178 putative acyl-acceptor binding pocket; other site 748449004179 cytidylate kinase; Provisional; Region: cmk; PRK00023 748449004180 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 748449004181 CMP-binding site; other site 748449004182 The sites determining sugar specificity; other site 748449004183 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 748449004184 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 748449004185 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449004186 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748449004187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449004188 DNA binding residues [nucleotide binding] 748449004189 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 748449004190 transmembrane helices; other site 748449004191 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 748449004192 TrkA-C domain; Region: TrkA_C; pfam02080 748449004193 TrkA-C domain; Region: TrkA_C; pfam02080 748449004194 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 748449004195 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 748449004196 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 748449004197 hinge; other site 748449004198 active site 748449004199 prephenate dehydrogenase; Validated; Region: PRK08507 748449004200 prephenate dehydrogenase; Validated; Region: PRK06545 748449004201 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 748449004202 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 748449004203 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 748449004204 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 748449004205 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748449004206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449004207 homodimer interface [polypeptide binding]; other site 748449004208 catalytic residue [active] 748449004209 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 748449004210 homotrimer interaction site [polypeptide binding]; other site 748449004211 active site 748449004212 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 748449004213 hexamer interface [polypeptide binding]; other site 748449004214 RNA binding site [nucleotide binding]; other site 748449004215 Histidine-zinc binding site [chemical binding]; other site 748449004216 flavoprotein, HI0933 family; Region: TIGR00275 748449004217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449004218 ribonuclease III; Reviewed; Region: rnc; PRK00102 748449004219 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 748449004220 dimerization interface [polypeptide binding]; other site 748449004221 active site 748449004222 metal binding site [ion binding]; metal-binding site 748449004223 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 748449004224 dsRNA binding site [nucleotide binding]; other site 748449004225 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 748449004226 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 748449004227 dimer interface [polypeptide binding]; other site 748449004228 active site 748449004229 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 748449004230 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 748449004231 FMN binding site [chemical binding]; other site 748449004232 substrate binding site [chemical binding]; other site 748449004233 putative catalytic residue [active] 748449004234 Phosphopantetheine attachment site; Region: PP-binding; cl09936 748449004235 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 748449004236 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 748449004237 NAD(P) binding site [chemical binding]; other site 748449004238 homotetramer interface [polypeptide binding]; other site 748449004239 homodimer interface [polypeptide binding]; other site 748449004240 active site 748449004241 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 748449004242 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 748449004243 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 748449004244 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 748449004245 FMN binding site [chemical binding]; other site 748449004246 substrate binding site [chemical binding]; other site 748449004247 putative catalytic residue [active] 748449004248 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 748449004249 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 748449004250 dimer interface [polypeptide binding]; other site 748449004251 active site 748449004252 CoA binding pocket [chemical binding]; other site 748449004253 putative phosphate acyltransferase; Provisional; Region: PRK05331 748449004254 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 748449004255 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 748449004256 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 748449004257 active site 2 [active] 748449004258 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 748449004259 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 748449004260 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 748449004261 propionate/acetate kinase; Provisional; Region: PRK12379 748449004262 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 748449004263 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 748449004264 hypothetical protein; Provisional; Region: PRK13670 748449004265 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 748449004266 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 748449004267 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 748449004268 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 748449004269 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 748449004270 active site 748449004271 nucleophile elbow; other site 748449004272 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 748449004273 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 748449004274 active site 748449004275 dimer interfaces [polypeptide binding]; other site 748449004276 catalytic residues [active] 748449004277 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 748449004278 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 748449004279 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 748449004280 trimer interface [polypeptide binding]; other site 748449004281 active site 748449004282 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 748449004283 catalytic site [active] 748449004284 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449004285 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449004286 DNA binding site [nucleotide binding] 748449004287 domain linker motif; other site 748449004288 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449004289 dimerization interface [polypeptide binding]; other site 748449004290 ligand binding site [chemical binding]; other site 748449004291 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 748449004292 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 748449004293 selenophosphate synthetase; Provisional; Region: PRK00943 748449004294 dimerization interface [polypeptide binding]; other site 748449004295 putative ATP binding site [chemical binding]; other site 748449004296 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 748449004297 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 748449004298 active site 748449004299 dimer interface [polypeptide binding]; other site 748449004300 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 748449004301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748449004302 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 748449004303 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 748449004304 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 748449004305 active site residue [active] 748449004306 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748449004307 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 748449004308 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 748449004309 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 748449004310 dimer interface [polypeptide binding]; other site 748449004311 ssDNA binding site [nucleotide binding]; other site 748449004312 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748449004313 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 748449004314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748449004315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748449004316 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 748449004317 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 748449004318 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 748449004319 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 748449004320 active site 748449004321 dimer interface [polypeptide binding]; other site 748449004322 effector binding site; other site 748449004323 TSCPD domain; Region: TSCPD; pfam12637 748449004324 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 748449004325 putative homodimer interface [polypeptide binding]; other site 748449004326 putative homotetramer interface [polypeptide binding]; other site 748449004327 putative allosteric switch controlling residues; other site 748449004328 putative metal binding site [ion binding]; other site 748449004329 putative homodimer-homodimer interface [polypeptide binding]; other site 748449004330 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748449004331 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 748449004332 catalytic residues [active] 748449004333 Protein of unknown function, DUF606; Region: DUF606; pfam04657 748449004334 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748449004335 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 748449004336 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748449004337 active site turn [active] 748449004338 phosphorylation site [posttranslational modification] 748449004339 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 748449004340 dimerization domain swap beta strand [polypeptide binding]; other site 748449004341 regulatory protein interface [polypeptide binding]; other site 748449004342 active site 748449004343 regulatory phosphorylation site [posttranslational modification]; other site 748449004344 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 748449004345 HPr interaction site; other site 748449004346 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748449004347 active site 748449004348 phosphorylation site [posttranslational modification] 748449004349 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748449004350 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 748449004351 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748449004352 active site turn [active] 748449004353 phosphorylation site [posttranslational modification] 748449004354 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 748449004355 HPr interaction site; other site 748449004356 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748449004357 active site 748449004358 phosphorylation site [posttranslational modification] 748449004359 CAT RNA binding domain; Region: CAT_RBD; smart01061 748449004360 transcriptional antiterminator BglG; Provisional; Region: PRK09772 748449004361 PRD domain; Region: PRD; pfam00874 748449004362 PRD domain; Region: PRD; pfam00874 748449004363 stage V sporulation protein T; Region: spore_V_T; TIGR02851 748449004364 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 748449004365 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 748449004366 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 748449004367 PEGA domain; Region: PEGA; pfam08308 748449004368 Predicted transcriptional regulators [Transcription]; Region: COG1695 748449004369 Transcriptional regulator PadR-like family; Region: PadR; cl17335 748449004370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748449004371 putative DNA binding site [nucleotide binding]; other site 748449004372 dimerization interface [polypeptide binding]; other site 748449004373 putative Zn2+ binding site [ion binding]; other site 748449004374 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748449004375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449004376 S-adenosylmethionine binding site [chemical binding]; other site 748449004377 reductive dehalogenase; Region: RDH; TIGR02486 748449004378 4Fe-4S binding domain; Region: Fer4; pfam00037 748449004379 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 748449004380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449004381 S-adenosylmethionine binding site [chemical binding]; other site 748449004382 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449004383 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 748449004384 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449004385 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449004386 putative active site [active] 748449004387 putative NTP binding site [chemical binding]; other site 748449004388 putative nucleic acid binding site [nucleotide binding]; other site 748449004389 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449004390 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 748449004391 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 748449004392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748449004393 Transposase; Region: HTH_Tnp_1; pfam01527 748449004394 putative transposase OrfB; Reviewed; Region: PHA02517 748449004395 HTH-like domain; Region: HTH_21; pfam13276 748449004396 Integrase core domain; Region: rve; pfam00665 748449004397 Integrase core domain; Region: rve_3; pfam13683 748449004398 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 748449004399 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449004400 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449004401 putative active site [active] 748449004402 putative NTP binding site [chemical binding]; other site 748449004403 putative nucleic acid binding site [nucleotide binding]; other site 748449004404 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449004405 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449004406 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449004407 putative active site [active] 748449004408 putative NTP binding site [chemical binding]; other site 748449004409 putative nucleic acid binding site [nucleotide binding]; other site 748449004410 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449004411 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 748449004412 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449004413 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449004414 putative active site [active] 748449004415 putative NTP binding site [chemical binding]; other site 748449004416 putative nucleic acid binding site [nucleotide binding]; other site 748449004417 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449004418 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 748449004419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748449004420 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 748449004421 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 748449004422 active site 748449004423 dimer interface [polypeptide binding]; other site 748449004424 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 748449004425 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 748449004426 active site 748449004427 FMN binding site [chemical binding]; other site 748449004428 substrate binding site [chemical binding]; other site 748449004429 3Fe-4S cluster binding site [ion binding]; other site 748449004430 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 748449004431 domain interface; other site 748449004432 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 748449004433 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 748449004434 Uncharacterized conserved protein [Function unknown]; Region: COG2966 748449004435 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 748449004436 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 748449004437 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 748449004438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748449004439 PAS fold; Region: PAS_3; pfam08447 748449004440 putative active site [active] 748449004441 heme pocket [chemical binding]; other site 748449004442 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748449004443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748449004444 metal binding site [ion binding]; metal-binding site 748449004445 active site 748449004446 I-site; other site 748449004447 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449004448 Zn2+ binding site [ion binding]; other site 748449004449 Mg2+ binding site [ion binding]; other site 748449004450 AAA domain; Region: AAA_32; pfam13654 748449004451 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 748449004452 Ion channel; Region: Ion_trans_2; pfam07885 748449004453 TrkA-N domain; Region: TrkA_N; pfam02254 748449004454 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 748449004455 dinuclear metal binding motif [ion binding]; other site 748449004456 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 748449004457 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 748449004458 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 748449004459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748449004460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748449004461 putative substrate translocation pore; other site 748449004462 Protein of unknown function (DUF441); Region: DUF441; cl01041 748449004463 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 748449004464 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 748449004465 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449004466 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 748449004467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 748449004468 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748449004469 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 748449004470 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 748449004471 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 748449004472 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 748449004473 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 748449004474 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 748449004475 Acylphosphatase; Region: Acylphosphatase; cl00551 748449004476 Response regulator receiver domain; Region: Response_reg; pfam00072 748449004477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748449004478 active site 748449004479 phosphorylation site [posttranslational modification] 748449004480 intermolecular recognition site; other site 748449004481 dimerization interface [polypeptide binding]; other site 748449004482 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 748449004483 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 748449004484 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 748449004485 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 748449004486 FAD binding domain; Region: FAD_binding_4; pfam01565 748449004487 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 748449004488 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 748449004489 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 748449004490 Ligand binding site; other site 748449004491 Putative Catalytic site; other site 748449004492 DXD motif; other site 748449004493 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 748449004494 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 748449004495 protein binding site [polypeptide binding]; other site 748449004496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748449004497 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748449004498 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748449004499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449004500 dimerization interface [polypeptide binding]; other site 748449004501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748449004502 dimer interface [polypeptide binding]; other site 748449004503 phosphorylation site [posttranslational modification] 748449004504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449004505 ATP binding site [chemical binding]; other site 748449004506 Mg2+ binding site [ion binding]; other site 748449004507 G-X-G motif; other site 748449004508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748449004509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748449004510 active site 748449004511 phosphorylation site [posttranslational modification] 748449004512 intermolecular recognition site; other site 748449004513 dimerization interface [polypeptide binding]; other site 748449004514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748449004515 DNA binding site [nucleotide binding] 748449004516 Cation transport protein; Region: TrkH; cl17365 748449004517 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 748449004518 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 748449004519 TrkA-N domain; Region: TrkA_N; pfam02254 748449004520 TrkA-C domain; Region: TrkA_C; pfam02080 748449004521 TrkA-N domain; Region: TrkA_N; pfam02254 748449004522 TrkA-C domain; Region: TrkA_C; pfam02080 748449004523 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 748449004524 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 748449004525 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 748449004526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449004527 binding surface 748449004528 TPR motif; other site 748449004529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748449004530 Transposase; Region: HTH_Tnp_1; pfam01527 748449004531 HTH-like domain; Region: HTH_21; pfam13276 748449004532 Integrase core domain; Region: rve; pfam00665 748449004533 Integrase core domain; Region: rve_3; pfam13683 748449004534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449004535 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748449004536 binding surface 748449004537 TPR motif; other site 748449004538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449004539 binding surface 748449004540 TPR motif; other site 748449004541 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748449004542 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748449004543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449004544 binding surface 748449004545 TPR motif; other site 748449004546 RHS Repeat; Region: RHS_repeat; pfam05593 748449004547 RHS Repeat; Region: RHS_repeat; pfam05593 748449004548 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 748449004549 RHS Repeat; Region: RHS_repeat; pfam05593 748449004550 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 748449004551 RHS Repeat; Region: RHS_repeat; cl11982 748449004552 RHS Repeat; Region: RHS_repeat; pfam05593 748449004553 RHS Repeat; Region: RHS_repeat; pfam05593 748449004554 RHS Repeat; Region: RHS_repeat; pfam05593 748449004555 RHS Repeat; Region: RHS_repeat; pfam05593 748449004556 RHS Repeat; Region: RHS_repeat; pfam05593 748449004557 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 748449004558 RHS Repeat; Region: RHS_repeat; cl11982 748449004559 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 748449004560 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 748449004561 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 748449004562 RHS Repeat; Region: RHS_repeat; cl11982 748449004563 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 748449004564 RHS Repeat; Region: RHS_repeat; pfam05593 748449004565 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 748449004566 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 748449004567 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449004568 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449004569 DNA binding site [nucleotide binding] 748449004570 domain linker motif; other site 748449004571 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449004572 dimerization interface [polypeptide binding]; other site 748449004573 ligand binding site [chemical binding]; other site 748449004574 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 748449004575 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 748449004576 Ca binding site [ion binding]; other site 748449004577 active site 748449004578 catalytic site [active] 748449004579 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 748449004580 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 748449004581 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 748449004582 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449004583 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748449004584 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449004585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449004586 dimer interface [polypeptide binding]; other site 748449004587 conserved gate region; other site 748449004588 putative PBP binding loops; other site 748449004589 ABC-ATPase subunit interface; other site 748449004590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449004591 dimer interface [polypeptide binding]; other site 748449004592 conserved gate region; other site 748449004593 putative PBP binding loops; other site 748449004594 ABC-ATPase subunit interface; other site 748449004595 beta-phosphoglucomutase; Region: bPGM; TIGR01990 748449004596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449004597 motif II; other site 748449004598 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 748449004599 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 748449004600 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 748449004601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 748449004602 NAD(P) binding site [chemical binding]; other site 748449004603 active site 748449004604 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 748449004605 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 748449004606 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 748449004607 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 748449004608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449004609 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748449004610 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449004611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449004612 dimer interface [polypeptide binding]; other site 748449004613 conserved gate region; other site 748449004614 putative PBP binding loops; other site 748449004615 ABC-ATPase subunit interface; other site 748449004616 sulfate transport protein; Provisional; Region: cysT; CHL00187 748449004617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449004618 dimer interface [polypeptide binding]; other site 748449004619 conserved gate region; other site 748449004620 putative PBP binding loops; other site 748449004621 ABC-ATPase subunit interface; other site 748449004622 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 748449004623 hydrophobic ligand binding site; other site 748449004624 RRXRR protein; Region: RRXRR; pfam14239 748449004625 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 748449004626 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 748449004627 active site 748449004628 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 748449004629 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 748449004630 inhibitor-cofactor binding pocket; inhibition site 748449004631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449004632 catalytic residue [active] 748449004633 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 748449004634 DHH family; Region: DHH; pfam01368 748449004635 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 748449004636 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 748449004637 Part of AAA domain; Region: AAA_19; pfam13245 748449004638 Family description; Region: UvrD_C_2; pfam13538 748449004639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 748449004640 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 748449004641 Probable transposase; Region: OrfB_IS605; pfam01385 748449004642 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748449004643 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 748449004644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449004645 dimerization interface [polypeptide binding]; other site 748449004646 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449004647 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449004648 dimer interface [polypeptide binding]; other site 748449004649 putative CheW interface [polypeptide binding]; other site 748449004650 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 748449004651 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 748449004652 TPP-binding site [chemical binding]; other site 748449004653 dimer interface [polypeptide binding]; other site 748449004654 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 748449004655 PYR/PP interface [polypeptide binding]; other site 748449004656 dimer interface [polypeptide binding]; other site 748449004657 TPP binding site [chemical binding]; other site 748449004658 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 748449004659 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 748449004660 active site 748449004661 intersubunit interactions; other site 748449004662 catalytic residue [active] 748449004663 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 748449004664 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 748449004665 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 748449004666 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 748449004667 intersubunit interface [polypeptide binding]; other site 748449004668 active site 748449004669 catalytic residue [active] 748449004670 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 748449004671 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 748449004672 active site 748449004673 catalytic motif [active] 748449004674 Zn binding site [ion binding]; other site 748449004675 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 748449004676 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 748449004677 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 748449004678 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 748449004679 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 748449004680 Protein export membrane protein; Region: SecD_SecF; cl14618 748449004681 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 748449004682 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748449004683 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 748449004684 HlyD family secretion protein; Region: HlyD_3; pfam13437 748449004685 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 748449004686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748449004687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748449004688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748449004689 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449004690 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449004691 putative active site [active] 748449004692 putative NTP binding site [chemical binding]; other site 748449004693 putative nucleic acid binding site [nucleotide binding]; other site 748449004694 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449004695 homoserine kinase; Provisional; Region: PRK01212 748449004696 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 748449004697 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 748449004698 aspartate kinase; Reviewed; Region: PRK06635 748449004699 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 748449004700 putative nucleotide binding site [chemical binding]; other site 748449004701 putative catalytic residues [active] 748449004702 putative Mg ion binding site [ion binding]; other site 748449004703 putative aspartate binding site [chemical binding]; other site 748449004704 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 748449004705 putative allosteric regulatory site; other site 748449004706 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 748449004707 putative allosteric regulatory residue; other site 748449004708 homoserine dehydrogenase; Provisional; Region: PRK06349 748449004709 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 748449004710 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 748449004711 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 748449004712 hypothetical protein; Provisional; Region: PRK04435 748449004713 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 748449004714 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 748449004715 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 748449004716 homodimer interface [polypeptide binding]; other site 748449004717 substrate-cofactor binding pocket; other site 748449004718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449004719 catalytic residue [active] 748449004720 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 748449004721 IHF - DNA interface [nucleotide binding]; other site 748449004722 IHF dimer interface [polypeptide binding]; other site 748449004723 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 748449004724 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 748449004725 G1 box; other site 748449004726 GTP/Mg2+ binding site [chemical binding]; other site 748449004727 G2 box; other site 748449004728 Switch I region; other site 748449004729 G3 box; other site 748449004730 Switch II region; other site 748449004731 G5 box; other site 748449004732 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 748449004733 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 748449004734 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 748449004735 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 748449004736 GTP-binding protein Der; Reviewed; Region: PRK00093 748449004737 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 748449004738 G1 box; other site 748449004739 GTP/Mg2+ binding site [chemical binding]; other site 748449004740 Switch I region; other site 748449004741 G2 box; other site 748449004742 Switch II region; other site 748449004743 G3 box; other site 748449004744 G4 box; other site 748449004745 G5 box; other site 748449004746 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 748449004747 G1 box; other site 748449004748 GTP/Mg2+ binding site [chemical binding]; other site 748449004749 Switch I region; other site 748449004750 G2 box; other site 748449004751 G3 box; other site 748449004752 Switch II region; other site 748449004753 G4 box; other site 748449004754 G5 box; other site 748449004755 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 748449004756 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 748449004757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449004758 FeS/SAM binding site; other site 748449004759 Protein of unknown function (DUF512); Region: DUF512; pfam04459 748449004760 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 748449004761 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 748449004762 YIEGIA protein; Region: YIEGIA; pfam14045 748449004763 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 748449004764 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 748449004765 phosphodiesterase; Provisional; Region: PRK12704 748449004766 Cor1/Xlr/Xmr conserved region; Region: Cor1; pfam04803 748449004767 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449004768 Zn2+ binding site [ion binding]; other site 748449004769 Mg2+ binding site [ion binding]; other site 748449004770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449004771 Walker B; other site 748449004772 D-loop; other site 748449004773 H-loop/switch region; other site 748449004774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449004775 AAA domain; Region: AAA_23; pfam13476 748449004776 Walker A/P-loop; other site 748449004777 ATP binding site [chemical binding]; other site 748449004778 Q-loop/lid; other site 748449004779 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 748449004780 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748449004781 active site 748449004782 metal binding site [ion binding]; metal-binding site 748449004783 DNA binding site [nucleotide binding] 748449004784 RecX family; Region: RecX; cl00936 748449004785 recombinase A; Provisional; Region: recA; PRK09354 748449004786 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 748449004787 hexamer interface [polypeptide binding]; other site 748449004788 Walker A motif; other site 748449004789 ATP binding site [chemical binding]; other site 748449004790 Walker B motif; other site 748449004791 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 748449004792 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 748449004793 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 748449004794 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748449004795 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 748449004796 active site 748449004797 metal binding site [ion binding]; metal-binding site 748449004798 competence damage-inducible protein A; Provisional; Region: PRK00549 748449004799 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 748449004800 putative MPT binding site; other site 748449004801 Competence-damaged protein; Region: CinA; pfam02464 748449004802 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 748449004803 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 748449004804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 748449004805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449004806 Walker B motif; other site 748449004807 arginine finger; other site 748449004808 Peptidase family M41; Region: Peptidase_M41; pfam01434 748449004809 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 748449004810 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 748449004811 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 748449004812 tetramer interfaces [polypeptide binding]; other site 748449004813 binuclear metal-binding site [ion binding]; other site 748449004814 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 748449004815 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 748449004816 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 748449004817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449004818 FeS/SAM binding site; other site 748449004819 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 748449004820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449004821 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 748449004822 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449004823 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449004824 putative active site [active] 748449004825 putative NTP binding site [chemical binding]; other site 748449004826 putative nucleic acid binding site [nucleotide binding]; other site 748449004827 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449004828 argininosuccinate lyase; Provisional; Region: PRK00855 748449004829 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 748449004830 active sites [active] 748449004831 tetramer interface [polypeptide binding]; other site 748449004832 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 748449004833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748449004834 Coenzyme A binding pocket [chemical binding]; other site 748449004835 argininosuccinate synthase; Provisional; Region: PRK13820 748449004836 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 748449004837 ANP binding site [chemical binding]; other site 748449004838 Substrate Binding Site II [chemical binding]; other site 748449004839 Substrate Binding Site I [chemical binding]; other site 748449004840 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 748449004841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748449004842 Coenzyme A binding pocket [chemical binding]; other site 748449004843 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 748449004844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449004845 FeS/SAM binding site; other site 748449004846 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 748449004847 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 748449004848 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 748449004849 Sulfate transporter family; Region: Sulfate_transp; pfam00916 748449004850 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 748449004851 ferric uptake regulator; Provisional; Region: fur; PRK09462 748449004852 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748449004853 metal binding site 2 [ion binding]; metal-binding site 748449004854 putative DNA binding helix; other site 748449004855 metal binding site 1 [ion binding]; metal-binding site 748449004856 dimer interface [polypeptide binding]; other site 748449004857 structural Zn2+ binding site [ion binding]; other site 748449004858 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 748449004859 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748449004860 ABC-ATPase subunit interface; other site 748449004861 dimer interface [polypeptide binding]; other site 748449004862 putative PBP binding regions; other site 748449004863 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 748449004864 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 748449004865 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 748449004866 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 748449004867 metal binding site [ion binding]; metal-binding site 748449004868 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 748449004869 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 748449004870 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449004871 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449004872 Peptidase family M23; Region: Peptidase_M23; pfam01551 748449004873 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 748449004874 PilZ domain; Region: PilZ; pfam07238 748449004875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 748449004876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449004877 dimerization interface [polypeptide binding]; other site 748449004878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 748449004879 putative active site [active] 748449004880 heme pocket [chemical binding]; other site 748449004881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748449004882 dimer interface [polypeptide binding]; other site 748449004883 phosphorylation site [posttranslational modification] 748449004884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449004885 ATP binding site [chemical binding]; other site 748449004886 Mg2+ binding site [ion binding]; other site 748449004887 G-X-G motif; other site 748449004888 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748449004889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748449004890 active site 748449004891 phosphorylation site [posttranslational modification] 748449004892 intermolecular recognition site; other site 748449004893 dimerization interface [polypeptide binding]; other site 748449004894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748449004895 DNA binding site [nucleotide binding] 748449004896 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 748449004897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449004898 active site 748449004899 motif I; other site 748449004900 motif II; other site 748449004901 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 748449004902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748449004903 DNA-binding site [nucleotide binding]; DNA binding site 748449004904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748449004905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449004906 homodimer interface [polypeptide binding]; other site 748449004907 catalytic residue [active] 748449004908 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 748449004909 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 748449004910 active site 748449004911 multimer interface [polypeptide binding]; other site 748449004912 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 748449004913 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 748449004914 predicted active site [active] 748449004915 catalytic triad [active] 748449004916 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 748449004917 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 748449004918 putative substrate binding site [chemical binding]; other site 748449004919 putative ATP binding site [chemical binding]; other site 748449004920 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 748449004921 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 748449004922 PAS domain S-box; Region: sensory_box; TIGR00229 748449004923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748449004924 putative active site [active] 748449004925 heme pocket [chemical binding]; other site 748449004926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449004927 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 748449004928 Walker A motif; other site 748449004929 ATP binding site [chemical binding]; other site 748449004930 Walker B motif; other site 748449004931 arginine finger; other site 748449004932 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 748449004933 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 748449004934 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 748449004935 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 748449004936 dimer interface [polypeptide binding]; other site 748449004937 active site 748449004938 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 748449004939 substrate binding site [chemical binding]; other site 748449004940 B12 cofactor binding site [chemical binding]; other site 748449004941 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 748449004942 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 748449004943 MutL protein; Region: MutL; pfam13941 748449004944 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 748449004945 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 748449004946 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 748449004947 B12 binding site [chemical binding]; other site 748449004948 heterodimer interface [polypeptide binding]; other site 748449004949 cobalt ligand [ion binding]; other site 748449004950 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748449004951 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748449004952 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 748449004953 Walker A/P-loop; other site 748449004954 ATP binding site [chemical binding]; other site 748449004955 Q-loop/lid; other site 748449004956 ABC transporter signature motif; other site 748449004957 Walker B; other site 748449004958 D-loop; other site 748449004959 H-loop/switch region; other site 748449004960 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 748449004961 phosphate binding site [ion binding]; other site 748449004962 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 748449004963 PHP domain; Region: PHP; pfam02811 748449004964 active site 748449004965 PspC domain; Region: PspC; pfam04024 748449004966 oligoendopeptidase F; Region: pepF; TIGR00181 748449004967 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 748449004968 active site 748449004969 Zn binding site [ion binding]; other site 748449004970 Homoserine O-succinyltransferase; Region: HTS; pfam04204 748449004971 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 748449004972 proposed active site lysine [active] 748449004973 conserved cys residue [active] 748449004974 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 748449004975 carbohydrate binding site [chemical binding]; other site 748449004976 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 748449004977 carbohydrate binding site [chemical binding]; other site 748449004978 pullulanase, type I; Region: pulA_typeI; TIGR02104 748449004979 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 748449004980 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 748449004981 Ca binding site [ion binding]; other site 748449004982 active site 748449004983 catalytic site [active] 748449004984 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 748449004985 carbohydrate binding site [chemical binding]; other site 748449004986 pullulanase, type I; Region: pulA_typeI; TIGR02104 748449004987 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 748449004988 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 748449004989 Ca binding site [ion binding]; other site 748449004990 active site 748449004991 catalytic site [active] 748449004992 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 748449004993 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 748449004994 FOG: CBS domain [General function prediction only]; Region: COG0517 748449004995 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 748449004996 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748449004997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748449004998 metal binding site [ion binding]; metal-binding site 748449004999 active site 748449005000 I-site; other site 748449005001 Predicted membrane protein [Function unknown]; Region: COG2855 748449005002 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 748449005003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748449005004 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 748449005005 putative dimerization interface [polypeptide binding]; other site 748449005006 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 748449005007 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 748449005008 active site 748449005009 metal binding site [ion binding]; metal-binding site 748449005010 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 748449005011 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 748449005012 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449005013 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 748449005014 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 748449005015 active site 748449005016 metal binding site [ion binding]; metal-binding site 748449005017 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 748449005018 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 748449005019 hypothetical protein; Provisional; Region: PRK11770 748449005020 Domain of unknown function (DUF307); Region: DUF307; pfam03733 748449005021 Domain of unknown function (DUF307); Region: DUF307; pfam03733 748449005022 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 748449005023 Uncharacterized membrane protein [Function unknown]; Region: COG3949 748449005024 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 748449005025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748449005026 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 748449005027 active site 748449005028 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 748449005029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 748449005030 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748449005031 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449005032 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 748449005033 Cache domain; Region: Cache_1; pfam02743 748449005034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449005035 dimerization interface [polypeptide binding]; other site 748449005036 dimer interface [polypeptide binding]; other site 748449005037 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449005038 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449005039 dimer interface [polypeptide binding]; other site 748449005040 putative CheW interface [polypeptide binding]; other site 748449005041 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 748449005042 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 748449005043 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 748449005044 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 748449005045 ATP cone domain; Region: ATP-cone; pfam03477 748449005046 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 748449005047 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 748449005048 sporulation sigma factor SigG; Reviewed; Region: PRK08215 748449005049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449005050 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748449005051 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449005052 DNA binding residues [nucleotide binding] 748449005053 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449005054 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449005055 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 748449005056 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748449005057 catalytic core [active] 748449005058 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748449005059 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748449005060 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 748449005061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748449005062 putative DNA binding site [nucleotide binding]; other site 748449005063 putative Zn2+ binding site [ion binding]; other site 748449005064 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748449005065 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748449005066 heat shock protein 90; Provisional; Region: PRK05218 748449005067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449005068 ATP binding site [chemical binding]; other site 748449005069 Mg2+ binding site [ion binding]; other site 748449005070 G-X-G motif; other site 748449005071 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 748449005072 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748449005073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449005074 homodimer interface [polypeptide binding]; other site 748449005075 catalytic residue [active] 748449005076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 748449005077 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 748449005078 Probable transposase; Region: OrfB_IS605; pfam01385 748449005079 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748449005080 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 748449005081 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 748449005082 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 748449005083 cobalamin synthase; Reviewed; Region: cobS; PRK00235 748449005084 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 748449005085 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 748449005086 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 748449005087 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 748449005088 catalytic triad [active] 748449005089 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 748449005090 cobyric acid synthase; Provisional; Region: PRK00784 748449005091 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748449005092 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748449005093 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 748449005094 catalytic triad [active] 748449005095 cobyric acid synthase; Provisional; Region: PRK00784 748449005096 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 748449005097 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 748449005098 catalytic triad [active] 748449005099 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 748449005100 homotrimer interface [polypeptide binding]; other site 748449005101 Walker A motif; other site 748449005102 GTP binding site [chemical binding]; other site 748449005103 Walker B motif; other site 748449005104 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 748449005105 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 748449005106 putative dimer interface [polypeptide binding]; other site 748449005107 active site pocket [active] 748449005108 putative cataytic base [active] 748449005109 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748449005110 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 748449005111 Walker A/P-loop; other site 748449005112 ATP binding site [chemical binding]; other site 748449005113 Q-loop/lid; other site 748449005114 ABC transporter signature motif; other site 748449005115 Walker B; other site 748449005116 D-loop; other site 748449005117 H-loop/switch region; other site 748449005118 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 748449005119 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748449005120 ABC-ATPase subunit interface; other site 748449005121 dimer interface [polypeptide binding]; other site 748449005122 putative PBP binding regions; other site 748449005123 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 748449005124 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 748449005125 cobalamin binding residues [chemical binding]; other site 748449005126 putative BtuC binding residues; other site 748449005127 dimer interface [polypeptide binding]; other site 748449005128 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748449005129 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748449005130 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 748449005131 Walker A/P-loop; other site 748449005132 ATP binding site [chemical binding]; other site 748449005133 Q-loop/lid; other site 748449005134 ABC transporter signature motif; other site 748449005135 Walker B; other site 748449005136 D-loop; other site 748449005137 H-loop/switch region; other site 748449005138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 748449005139 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 748449005140 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748449005141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748449005142 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 748449005143 Walker A/P-loop; other site 748449005144 ATP binding site [chemical binding]; other site 748449005145 Q-loop/lid; other site 748449005146 ABC transporter signature motif; other site 748449005147 Walker B; other site 748449005148 D-loop; other site 748449005149 H-loop/switch region; other site 748449005150 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748449005151 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748449005152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449005153 Walker A/P-loop; other site 748449005154 ATP binding site [chemical binding]; other site 748449005155 Q-loop/lid; other site 748449005156 ABC transporter signature motif; other site 748449005157 Walker B; other site 748449005158 D-loop; other site 748449005159 H-loop/switch region; other site 748449005160 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 748449005161 substrate binding site [chemical binding]; other site 748449005162 active site 748449005163 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 748449005164 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 748449005165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449005166 dimerization interface [polypeptide binding]; other site 748449005167 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449005168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449005169 dimer interface [polypeptide binding]; other site 748449005170 putative CheW interface [polypeptide binding]; other site 748449005171 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 748449005172 putative metal binding site [ion binding]; other site 748449005173 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 748449005174 Ca binding site [ion binding]; other site 748449005175 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 748449005176 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 748449005177 substrate binding site [chemical binding]; other site 748449005178 active site 748449005179 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 748449005180 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 748449005181 substrate binding site [chemical binding]; other site 748449005182 active site 748449005183 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 748449005184 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 748449005185 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 748449005186 substrate binding site [chemical binding]; other site 748449005187 active site 748449005188 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 748449005189 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 748449005190 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 748449005191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748449005192 Walker A/P-loop; other site 748449005193 ATP binding site [chemical binding]; other site 748449005194 Q-loop/lid; other site 748449005195 ABC transporter signature motif; other site 748449005196 Walker B; other site 748449005197 D-loop; other site 748449005198 H-loop/switch region; other site 748449005199 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 748449005200 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 748449005201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748449005202 Walker A/P-loop; other site 748449005203 ATP binding site [chemical binding]; other site 748449005204 Q-loop/lid; other site 748449005205 ABC transporter signature motif; other site 748449005206 Walker B; other site 748449005207 D-loop; other site 748449005208 H-loop/switch region; other site 748449005209 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 748449005210 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 748449005211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 748449005212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449005213 dimer interface [polypeptide binding]; other site 748449005214 conserved gate region; other site 748449005215 putative PBP binding loops; other site 748449005216 ABC-ATPase subunit interface; other site 748449005217 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 748449005218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449005219 dimer interface [polypeptide binding]; other site 748449005220 conserved gate region; other site 748449005221 putative PBP binding loops; other site 748449005222 ABC-ATPase subunit interface; other site 748449005223 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 748449005224 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 748449005225 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449005226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449005227 DNA binding site [nucleotide binding] 748449005228 domain linker motif; other site 748449005229 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449005230 dimerization interface [polypeptide binding]; other site 748449005231 ligand binding site [chemical binding]; other site 748449005232 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 748449005233 active site 748449005234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748449005235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748449005236 putative substrate translocation pore; other site 748449005237 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 748449005238 active site 748449005239 catalytic residues [active] 748449005240 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 748449005241 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748449005242 active site 748449005243 catalytic tetrad [active] 748449005244 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748449005245 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 748449005246 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 748449005247 TPP-binding site [chemical binding]; other site 748449005248 dimer interface [polypeptide binding]; other site 748449005249 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 748449005250 PYR/PP interface [polypeptide binding]; other site 748449005251 dimer interface [polypeptide binding]; other site 748449005252 TPP binding site [chemical binding]; other site 748449005253 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 748449005254 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 748449005255 active site 748449005256 intersubunit interactions; other site 748449005257 catalytic residue [active] 748449005258 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 748449005259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449005260 active site 748449005261 motif I; other site 748449005262 motif II; other site 748449005263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449005264 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 748449005265 active site 748449005266 metal binding site [ion binding]; metal-binding site 748449005267 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 748449005268 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 748449005269 putative N- and C-terminal domain interface [polypeptide binding]; other site 748449005270 putative active site [active] 748449005271 MgATP binding site [chemical binding]; other site 748449005272 catalytic site [active] 748449005273 metal binding site [ion binding]; metal-binding site 748449005274 putative carbohydrate binding site [chemical binding]; other site 748449005275 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 748449005276 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 748449005277 intersubunit interface [polypeptide binding]; other site 748449005278 active site 748449005279 Zn2+ binding site [ion binding]; other site 748449005280 L-arabinose isomerase; Provisional; Region: PRK02929 748449005281 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 748449005282 hexamer (dimer of trimers) interface [polypeptide binding]; other site 748449005283 trimer interface [polypeptide binding]; other site 748449005284 substrate binding site [chemical binding]; other site 748449005285 Mn binding site [ion binding]; other site 748449005286 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748449005287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748449005288 DNA-binding site [nucleotide binding]; DNA binding site 748449005289 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449005290 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 748449005291 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 748449005292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 748449005293 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449005294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449005295 dimer interface [polypeptide binding]; other site 748449005296 conserved gate region; other site 748449005297 putative PBP binding loops; other site 748449005298 ABC-ATPase subunit interface; other site 748449005299 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 748449005300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449005301 dimer interface [polypeptide binding]; other site 748449005302 conserved gate region; other site 748449005303 putative PBP binding loops; other site 748449005304 ABC-ATPase subunit interface; other site 748449005305 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449005306 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748449005307 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449005308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449005309 DNA binding site [nucleotide binding] 748449005310 domain linker motif; other site 748449005311 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449005312 dimerization interface [polypeptide binding]; other site 748449005313 ligand binding site [chemical binding]; other site 748449005314 nickel responsive regulator; Provisional; Region: PRK04460 748449005315 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 748449005316 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 748449005317 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647 748449005318 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748449005319 Walker A/P-loop; other site 748449005320 ATP binding site [chemical binding]; other site 748449005321 Q-loop/lid; other site 748449005322 ABC transporter signature motif; other site 748449005323 Walker B; other site 748449005324 D-loop; other site 748449005325 H-loop/switch region; other site 748449005326 Cobalt transport protein; Region: CbiQ; cl00463 748449005327 PDGLE domain; Region: PDGLE; cl07986 748449005328 cobalt transport protein CbiM; Validated; Region: PRK06265 748449005329 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 748449005330 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 748449005331 Mechanosensitive ion channel; Region: MS_channel; pfam00924 748449005332 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 748449005333 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 748449005334 substrate binding pocket [chemical binding]; other site 748449005335 chain length determination region; other site 748449005336 substrate-Mg2+ binding site; other site 748449005337 catalytic residues [active] 748449005338 aspartate-rich region 1; other site 748449005339 active site lid residues [active] 748449005340 aspartate-rich region 2; other site 748449005341 sporulation sigma factor SigE; Reviewed; Region: PRK08301 748449005342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449005343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449005344 DNA binding residues [nucleotide binding] 748449005345 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 748449005346 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 748449005347 cell division protein FtsZ; Validated; Region: PRK09330 748449005348 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 748449005349 nucleotide binding site [chemical binding]; other site 748449005350 SulA interaction site; other site 748449005351 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 748449005352 Cell division protein FtsA; Region: FtsA; smart00842 748449005353 Cell division protein FtsA; Region: FtsA; pfam14450 748449005354 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 748449005355 Cell division protein FtsQ; Region: FtsQ; pfam03799 748449005356 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 748449005357 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 748449005358 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748449005359 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 748449005360 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 748449005361 hinge; other site 748449005362 active site 748449005363 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 748449005364 FAD binding domain; Region: FAD_binding_4; pfam01565 748449005365 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 748449005366 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 748449005367 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 748449005368 active site 748449005369 homodimer interface [polypeptide binding]; other site 748449005370 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 748449005371 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 748449005372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748449005373 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748449005374 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 748449005375 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 748449005376 Mg++ binding site [ion binding]; other site 748449005377 putative catalytic motif [active] 748449005378 putative substrate binding site [chemical binding]; other site 748449005379 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 748449005380 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 748449005381 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748449005382 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748449005383 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 748449005384 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 748449005385 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748449005386 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748449005387 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 748449005388 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748449005389 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 748449005390 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 748449005391 Cell division protein FtsL; Region: FtsL; cl11433 748449005392 MraW methylase family; Region: Methyltransf_5; pfam01795 748449005393 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 748449005394 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 748449005395 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 748449005396 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 748449005397 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 748449005398 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449005399 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449005400 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 748449005401 Competence protein A; Region: Competence_A; pfam11104 748449005402 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 748449005403 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 748449005404 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 748449005405 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 748449005406 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 748449005407 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 748449005408 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 748449005409 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 748449005410 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 748449005411 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748449005412 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748449005413 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 748449005414 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 748449005415 Walker A motif; other site 748449005416 ATP binding site [chemical binding]; other site 748449005417 Walker B motif; other site 748449005418 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 748449005419 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 748449005420 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 748449005421 Walker A motif; other site 748449005422 ATP binding site [chemical binding]; other site 748449005423 Walker B motif; other site 748449005424 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 748449005425 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 748449005426 Ligand Binding Site [chemical binding]; other site 748449005427 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 748449005428 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 748449005429 trimerization site [polypeptide binding]; other site 748449005430 active site 748449005431 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 748449005432 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 748449005433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748449005434 catalytic residue [active] 748449005435 Predicted transcriptional regulator [Transcription]; Region: COG1959 748449005436 Transcriptional regulator; Region: Rrf2; cl17282 748449005437 Uncharacterized conserved protein [Function unknown]; Region: COG1739 748449005438 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 748449005439 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 748449005440 recombination factor protein RarA; Reviewed; Region: PRK13342 748449005441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449005442 Walker A motif; other site 748449005443 ATP binding site [chemical binding]; other site 748449005444 Walker B motif; other site 748449005445 arginine finger; other site 748449005446 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 748449005447 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 748449005448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449005449 active site 748449005450 motif I; other site 748449005451 motif II; other site 748449005452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449005453 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748449005454 active site 748449005455 motif I; other site 748449005456 motif II; other site 748449005457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449005458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449005459 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748449005460 active site 748449005461 motif I; other site 748449005462 motif II; other site 748449005463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449005464 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 748449005465 ADP-glucose phosphorylase; Region: PLN02643 748449005466 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 748449005467 nucleotide binding site/active site [active] 748449005468 HIT family signature motif; other site 748449005469 catalytic residue [active] 748449005470 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 748449005471 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 748449005472 putative ADP-binding pocket [chemical binding]; other site 748449005473 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 748449005474 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 748449005475 putative substrate binding site [chemical binding]; other site 748449005476 putative ATP binding site [chemical binding]; other site 748449005477 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449005478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449005479 dimer interface [polypeptide binding]; other site 748449005480 conserved gate region; other site 748449005481 putative PBP binding loops; other site 748449005482 ABC-ATPase subunit interface; other site 748449005483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449005484 dimer interface [polypeptide binding]; other site 748449005485 conserved gate region; other site 748449005486 ABC-ATPase subunit interface; other site 748449005487 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449005488 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748449005489 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449005490 DNA binding site [nucleotide binding] 748449005491 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449005492 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449005493 DNA binding site [nucleotide binding] 748449005494 domain linker motif; other site 748449005495 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449005496 dimerization interface [polypeptide binding]; other site 748449005497 ligand binding site [chemical binding]; other site 748449005498 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 748449005499 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 748449005500 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 748449005501 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 748449005502 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 748449005503 Trehalase; Region: Trehalase; cl17346 748449005504 Protein of unknown function, DUF608; Region: DUF608; pfam04685 748449005505 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748449005506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449005507 dimer interface [polypeptide binding]; other site 748449005508 conserved gate region; other site 748449005509 putative PBP binding loops; other site 748449005510 ABC-ATPase subunit interface; other site 748449005511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449005512 dimer interface [polypeptide binding]; other site 748449005513 conserved gate region; other site 748449005514 putative PBP binding loops; other site 748449005515 ABC-ATPase subunit interface; other site 748449005516 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748449005517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748449005518 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449005519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449005520 DNA binding site [nucleotide binding] 748449005521 domain linker motif; other site 748449005522 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449005523 dimerization interface [polypeptide binding]; other site 748449005524 ligand binding site [chemical binding]; other site 748449005525 beta-phosphoglucomutase; Region: bPGM; TIGR01990 748449005526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449005527 motif II; other site 748449005528 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 748449005529 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 748449005530 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449005531 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449005532 putative active site [active] 748449005533 putative NTP binding site [chemical binding]; other site 748449005534 putative nucleic acid binding site [nucleotide binding]; other site 748449005535 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449005536 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 748449005537 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 748449005538 dimer interface [polypeptide binding]; other site 748449005539 anticodon binding site; other site 748449005540 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 748449005541 homodimer interface [polypeptide binding]; other site 748449005542 motif 1; other site 748449005543 active site 748449005544 motif 2; other site 748449005545 GAD domain; Region: GAD; pfam02938 748449005546 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 748449005547 motif 3; other site 748449005548 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 748449005549 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 748449005550 dimer interface [polypeptide binding]; other site 748449005551 motif 1; other site 748449005552 active site 748449005553 motif 2; other site 748449005554 motif 3; other site 748449005555 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 748449005556 anticodon binding site; other site 748449005557 SurA N-terminal domain; Region: SurA_N_3; cl07813 748449005558 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 748449005559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449005560 binding surface 748449005561 TPR motif; other site 748449005562 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748449005563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449005564 binding surface 748449005565 TPR motif; other site 748449005566 TPR repeat; Region: TPR_11; pfam13414 748449005567 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 748449005568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449005569 FeS/SAM binding site; other site 748449005570 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 748449005571 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 748449005572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449005573 Zn2+ binding site [ion binding]; other site 748449005574 Mg2+ binding site [ion binding]; other site 748449005575 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 748449005576 synthetase active site [active] 748449005577 NTP binding site [chemical binding]; other site 748449005578 metal binding site [ion binding]; metal-binding site 748449005579 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 748449005580 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 748449005581 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748449005582 active site 748449005583 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 748449005584 DHH family; Region: DHH; pfam01368 748449005585 DHHA1 domain; Region: DHHA1; pfam02272 748449005586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449005587 nucleotide binding region [chemical binding]; other site 748449005588 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 748449005589 ABC1 family; Region: ABC1; pfam03109 748449005590 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 748449005591 active site 748449005592 ATP binding site [chemical binding]; other site 748449005593 Protein of unknown function (DUF456); Region: DUF456; pfam04306 748449005594 Uncharacterized conserved protein [Function unknown]; Region: COG3937 748449005595 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 748449005596 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 748449005597 Protein export membrane protein; Region: SecD_SecF; pfam02355 748449005598 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 748449005599 protein-export membrane protein SecD; Region: secD; TIGR01129 748449005600 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 748449005601 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449005602 Zn2+ binding site [ion binding]; other site 748449005603 Mg2+ binding site [ion binding]; other site 748449005604 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 748449005605 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 748449005606 Catalytic site [active] 748449005607 Preprotein translocase subunit; Region: YajC; pfam02699 748449005608 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 748449005609 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 748449005610 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 748449005611 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 748449005612 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 748449005613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449005614 Walker A motif; other site 748449005615 ATP binding site [chemical binding]; other site 748449005616 Walker B motif; other site 748449005617 arginine finger; other site 748449005618 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 748449005619 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 748449005620 RuvA N terminal domain; Region: RuvA_N; pfam01330 748449005621 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 748449005622 hypothetical protein; Validated; Region: PRK00110 748449005623 prephenate dehydratase; Provisional; Region: PRK11898 748449005624 Prephenate dehydratase; Region: PDT; pfam00800 748449005625 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 748449005626 putative L-Phe binding site [chemical binding]; other site 748449005627 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 748449005628 RNA/DNA hybrid binding site [nucleotide binding]; other site 748449005629 active site 748449005630 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 748449005631 Putative zinc ribbon domain; Region: DUF164; pfam02591 748449005632 Uncharacterized conserved protein [Function unknown]; Region: COG0327 748449005633 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 748449005634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 748449005635 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 748449005636 Uncharacterized conserved protein [Function unknown]; Region: COG0327 748449005637 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 748449005638 Family of unknown function (DUF633); Region: DUF633; pfam04816 748449005639 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 748449005640 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 748449005641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449005642 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748449005643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449005644 DNA binding residues [nucleotide binding] 748449005645 DNA primase; Validated; Region: dnaG; PRK05667 748449005646 CHC2 zinc finger; Region: zf-CHC2; pfam01807 748449005647 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 748449005648 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 748449005649 active site 748449005650 metal binding site [ion binding]; metal-binding site 748449005651 interdomain interaction site; other site 748449005652 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 748449005653 PEP synthetase regulatory protein; Provisional; Region: PRK05339 748449005654 HTH domain; Region: HTH_11; pfam08279 748449005655 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 748449005656 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 748449005657 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 748449005658 putative active site [active] 748449005659 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 748449005660 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 748449005661 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 748449005662 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 748449005663 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 748449005664 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 748449005665 DALR anticodon binding domain; Region: DALR_1; pfam05746 748449005666 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 748449005667 dimer interface [polypeptide binding]; other site 748449005668 motif 1; other site 748449005669 active site 748449005670 motif 2; other site 748449005671 motif 3; other site 748449005672 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 748449005673 Recombination protein O N terminal; Region: RecO_N; pfam11967 748449005674 DNA repair protein RecO; Region: reco; TIGR00613 748449005675 Recombination protein O C terminal; Region: RecO_C; pfam02565 748449005676 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 748449005677 intersubunit interface [polypeptide binding]; other site 748449005678 active site 748449005679 catalytic residue [active] 748449005680 GTPase Era; Reviewed; Region: era; PRK00089 748449005681 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 748449005682 G1 box; other site 748449005683 GTP/Mg2+ binding site [chemical binding]; other site 748449005684 Switch I region; other site 748449005685 G2 box; other site 748449005686 Switch II region; other site 748449005687 G3 box; other site 748449005688 G4 box; other site 748449005689 G5 box; other site 748449005690 KH domain; Region: KH_2; pfam07650 748449005691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748449005692 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 748449005693 Coenzyme A binding pocket [chemical binding]; other site 748449005694 CotJB protein; Region: CotJB; pfam12652 748449005695 Uncharacterized conserved protein [Function unknown]; Region: COG2928 748449005696 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 748449005697 Domain of unknown function DUF21; Region: DUF21; pfam01595 748449005698 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 748449005699 Transporter associated domain; Region: CorC_HlyC; smart01091 748449005700 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 748449005701 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 748449005702 active site 748449005703 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 748449005704 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 748449005705 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 748449005706 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449005707 Zn2+ binding site [ion binding]; other site 748449005708 Mg2+ binding site [ion binding]; other site 748449005709 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 748449005710 PhoH-like protein; Region: PhoH; pfam02562 748449005711 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 748449005712 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 748449005713 YabP family; Region: YabP; cl06766 748449005714 Yqey-like protein; Region: YqeY; pfam09424 748449005715 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 748449005716 nucleotide binding site/active site [active] 748449005717 HIT family signature motif; other site 748449005718 catalytic residue [active] 748449005719 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 748449005720 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 748449005721 RRXRR protein; Region: RRXRR; pfam14239 748449005722 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 748449005723 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 748449005724 active site 748449005725 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 748449005726 RNA methyltransferase, RsmE family; Region: TIGR00046 748449005727 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 748449005728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449005729 S-adenosylmethionine binding site [chemical binding]; other site 748449005730 chaperone protein DnaJ; Provisional; Region: PRK10767 748449005731 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 748449005732 HSP70 interaction site [polypeptide binding]; other site 748449005733 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 748449005734 substrate binding site [polypeptide binding]; other site 748449005735 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 748449005736 Zn binding sites [ion binding]; other site 748449005737 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 748449005738 dimer interface [polypeptide binding]; other site 748449005739 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 748449005740 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 748449005741 nucleotide binding site [chemical binding]; other site 748449005742 NEF interaction site [polypeptide binding]; other site 748449005743 SBD interface [polypeptide binding]; other site 748449005744 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 748449005745 dimer interface [polypeptide binding]; other site 748449005746 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 748449005747 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 748449005748 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 748449005749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449005750 FeS/SAM binding site; other site 748449005751 HemN C-terminal domain; Region: HemN_C; pfam06969 748449005752 GTP-binding protein LepA; Provisional; Region: PRK05433 748449005753 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 748449005754 G1 box; other site 748449005755 putative GEF interaction site [polypeptide binding]; other site 748449005756 GTP/Mg2+ binding site [chemical binding]; other site 748449005757 Switch I region; other site 748449005758 G2 box; other site 748449005759 G3 box; other site 748449005760 Switch II region; other site 748449005761 G4 box; other site 748449005762 G5 box; other site 748449005763 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 748449005764 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 748449005765 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 748449005766 stage II sporulation protein P; Region: spore_II_P; TIGR02867 748449005767 germination protease; Provisional; Region: PRK12362 748449005768 Membrane protein of unknown function; Region: DUF360; pfam04020 748449005769 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 748449005770 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 748449005771 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 748449005772 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748449005773 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 748449005774 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748449005775 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 748449005776 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 748449005777 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 748449005778 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 748449005779 Competence protein; Region: Competence; pfam03772 748449005780 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748449005781 SLBB domain; Region: SLBB; pfam10531 748449005782 comEA protein; Region: comE; TIGR01259 748449005783 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 748449005784 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 748449005785 HIGH motif; other site 748449005786 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 748449005787 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 748449005788 active site 748449005789 KMSKS motif; other site 748449005790 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 748449005791 tRNA binding surface [nucleotide binding]; other site 748449005792 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 748449005793 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 748449005794 Transcriptional regulator [Transcription]; Region: LytR; COG1316 748449005795 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 748449005796 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449005797 Zn2+ binding site [ion binding]; other site 748449005798 Mg2+ binding site [ion binding]; other site 748449005799 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 748449005800 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 748449005801 active site 748449005802 (T/H)XGH motif; other site 748449005803 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 748449005804 TrkA-N domain; Region: TrkA_N; pfam02254 748449005805 TrkA-C domain; Region: TrkA_C; pfam02080 748449005806 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 748449005807 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 748449005808 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 748449005809 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 748449005810 dimerization interface [polypeptide binding]; other site 748449005811 domain crossover interface; other site 748449005812 redox-dependent activation switch; other site 748449005813 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 748449005814 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 748449005815 active site 748449005816 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 748449005817 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 748449005818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449005819 Zn2+ binding site [ion binding]; other site 748449005820 Mg2+ binding site [ion binding]; other site 748449005821 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 748449005822 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 748449005823 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 748449005824 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 748449005825 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 748449005826 Outer membrane efflux protein; Region: OEP; pfam02321 748449005827 Outer membrane efflux protein; Region: OEP; pfam02321 748449005828 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 748449005829 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 748449005830 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 748449005831 HlyD family secretion protein; Region: HlyD_3; pfam13437 748449005832 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 748449005833 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 748449005834 putative active site [active] 748449005835 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748449005836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449005837 Walker A/P-loop; other site 748449005838 ATP binding site [chemical binding]; other site 748449005839 Q-loop/lid; other site 748449005840 ABC transporter signature motif; other site 748449005841 Walker B; other site 748449005842 D-loop; other site 748449005843 H-loop/switch region; other site 748449005844 Integrase core domain; Region: rve; pfam00665 748449005845 Integrase core domain; Region: rve_3; pfam13683 748449005846 Transposase; Region: HTH_Tnp_1; cl17663 748449005847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748449005848 HTH-like domain; Region: HTH_21; pfam13276 748449005849 Integrase core domain; Region: rve; pfam00665 748449005850 Integrase core domain; Region: rve_3; pfam13683 748449005851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748449005852 Transposase; Region: HTH_Tnp_1; pfam01527 748449005853 CAAX protease self-immunity; Region: Abi; pfam02517 748449005854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 748449005855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 748449005856 DNA binding residues [nucleotide binding] 748449005857 dimerization interface [polypeptide binding]; other site 748449005858 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 748449005859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 748449005860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 748449005861 DNA binding residues [nucleotide binding] 748449005862 dimerization interface [polypeptide binding]; other site 748449005863 CAAX protease self-immunity; Region: Abi; pfam02517 748449005864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748449005865 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748449005866 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748449005867 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 748449005868 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 748449005869 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 748449005870 catalytic residues [active] 748449005871 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 748449005872 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 748449005873 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 748449005874 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 748449005875 putative catalytic cysteine [active] 748449005876 gamma-glutamyl kinase; Provisional; Region: PRK05429 748449005877 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 748449005878 nucleotide binding site [chemical binding]; other site 748449005879 homotetrameric interface [polypeptide binding]; other site 748449005880 putative phosphate binding site [ion binding]; other site 748449005881 putative allosteric binding site; other site 748449005882 PUA domain; Region: PUA; pfam01472 748449005883 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 748449005884 GTPase CgtA; Reviewed; Region: obgE; PRK12297 748449005885 GTP1/OBG; Region: GTP1_OBG; pfam01018 748449005886 Obg GTPase; Region: Obg; cd01898 748449005887 G1 box; other site 748449005888 GTP/Mg2+ binding site [chemical binding]; other site 748449005889 Switch I region; other site 748449005890 G2 box; other site 748449005891 G3 box; other site 748449005892 Switch II region; other site 748449005893 G4 box; other site 748449005894 G5 box; other site 748449005895 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 748449005896 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 748449005897 Protein of unknown function (DUF464); Region: DUF464; pfam04327 748449005898 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 748449005899 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 748449005900 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 748449005901 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 748449005902 homodimer interface [polypeptide binding]; other site 748449005903 oligonucleotide binding site [chemical binding]; other site 748449005904 TRAM domain; Region: TRAM; cl01282 748449005905 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 748449005906 Peptidase family M50; Region: Peptidase_M50; pfam02163 748449005907 active site 748449005908 putative substrate binding region [chemical binding]; other site 748449005909 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 748449005910 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 748449005911 septum site-determining protein MinD; Region: minD_bact; TIGR01968 748449005912 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 748449005913 P-loop; other site 748449005914 ADP binding residues [chemical binding]; other site 748449005915 Switch I; other site 748449005916 Switch II; other site 748449005917 septum formation inhibitor; Reviewed; Region: minC; PRK00513 748449005918 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 748449005919 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 748449005920 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748449005921 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 748449005922 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 748449005923 rod shape-determining protein MreC; Provisional; Region: PRK13922 748449005924 rod shape-determining protein MreC; Region: MreC; pfam04085 748449005925 rod shape-determining protein MreB; Provisional; Region: PRK13927 748449005926 MreB and similar proteins; Region: MreB_like; cd10225 748449005927 nucleotide binding site [chemical binding]; other site 748449005928 Mg binding site [ion binding]; other site 748449005929 putative protofilament interaction site [polypeptide binding]; other site 748449005930 RodZ interaction site [polypeptide binding]; other site 748449005931 hypothetical protein; Reviewed; Region: PRK00024 748449005932 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 748449005933 MPN+ (JAMM) motif; other site 748449005934 Zinc-binding site [ion binding]; other site 748449005935 Maf-like protein; Region: Maf; pfam02545 748449005936 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 748449005937 active site 748449005938 dimer interface [polypeptide binding]; other site 748449005939 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 748449005940 FMN-binding domain; Region: FMN_bind; pfam04205 748449005941 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 748449005942 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 748449005943 substrate binding pocket [chemical binding]; other site 748449005944 chain length determination region; other site 748449005945 substrate-Mg2+ binding site; other site 748449005946 catalytic residues [active] 748449005947 aspartate-rich region 1; other site 748449005948 active site lid residues [active] 748449005949 aspartate-rich region 2; other site 748449005950 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 748449005951 ApbE family; Region: ApbE; pfam02424 748449005952 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748449005953 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 748449005954 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 748449005955 Predicted membrane protein [Function unknown]; Region: COG2259 748449005956 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 748449005957 Domain of unknown function DUF302; Region: DUF302; cl01364 748449005958 ferredoxin; Validated; Region: PRK07118 748449005959 Putative Fe-S cluster; Region: FeS; cl17515 748449005960 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748449005961 4Fe-4S binding domain; Region: Fer4; pfam00037 748449005962 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748449005963 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 748449005964 electron transport complex RsxE subunit; Provisional; Region: PRK12405 748449005965 FMN-binding domain; Region: FMN_bind; cl01081 748449005966 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 748449005967 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 748449005968 SLBB domain; Region: SLBB; pfam10531 748449005969 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748449005970 PHP domain; Region: PHP; pfam02811 748449005971 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 748449005972 active site 748449005973 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 748449005974 DRTGG domain; Region: DRTGG; pfam07085 748449005975 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 748449005976 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748449005977 Putative Fe-S cluster; Region: FeS; cl17515 748449005978 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 748449005979 ATP binding site [chemical binding]; other site 748449005980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 748449005981 Mg2+ binding site [ion binding]; other site 748449005982 G-X-G motif; other site 748449005983 DRTGG domain; Region: DRTGG; pfam07085 748449005984 Sporulation related domain; Region: SPOR; pfam05036 748449005985 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 748449005986 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748449005987 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748449005988 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748449005989 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748449005990 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748449005991 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 748449005992 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 748449005993 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748449005994 active site 748449005995 HIGH motif; other site 748449005996 nucleotide binding site [chemical binding]; other site 748449005997 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 748449005998 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 748449005999 active site 748449006000 KMSKS motif; other site 748449006001 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 748449006002 tRNA binding surface [nucleotide binding]; other site 748449006003 anticodon binding site; other site 748449006004 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 748449006005 CAAX protease self-immunity; Region: Abi; pfam02517 748449006006 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 748449006007 UbiA prenyltransferase family; Region: UbiA; pfam01040 748449006008 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 748449006009 G1 box; other site 748449006010 GTP/Mg2+ binding site [chemical binding]; other site 748449006011 Switch I region; other site 748449006012 G2 box; other site 748449006013 G3 box; other site 748449006014 Switch II region; other site 748449006015 G4 box; other site 748449006016 G5 box; other site 748449006017 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 748449006018 Found in ATP-dependent protease La (LON); Region: LON; smart00464 748449006019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449006020 Walker A motif; other site 748449006021 ATP binding site [chemical binding]; other site 748449006022 Walker B motif; other site 748449006023 arginine finger; other site 748449006024 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 748449006025 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 748449006026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449006027 Walker A motif; other site 748449006028 ATP binding site [chemical binding]; other site 748449006029 Walker B motif; other site 748449006030 arginine finger; other site 748449006031 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 748449006032 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 748449006033 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 748449006034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449006035 Walker A motif; other site 748449006036 ATP binding site [chemical binding]; other site 748449006037 Walker B motif; other site 748449006038 arginine finger; other site 748449006039 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 748449006040 Clp protease; Region: CLP_protease; pfam00574 748449006041 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 748449006042 oligomer interface [polypeptide binding]; other site 748449006043 active site residues [active] 748449006044 trigger factor; Provisional; Region: tig; PRK01490 748449006045 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 748449006046 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 748449006047 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 748449006048 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748449006049 active site 748449006050 metal binding site [ion binding]; metal-binding site 748449006051 homotetramer interface [polypeptide binding]; other site 748449006052 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 748449006053 active site 748449006054 dimerization interface [polypeptide binding]; other site 748449006055 ribonuclease PH; Reviewed; Region: rph; PRK00173 748449006056 Ribonuclease PH; Region: RNase_PH_bact; cd11362 748449006057 hexamer interface [polypeptide binding]; other site 748449006058 active site 748449006059 Fumarase C-terminus; Region: Fumerase_C; cl00795 748449006060 fumarate hydratase; Provisional; Region: PRK06246 748449006061 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 748449006062 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 748449006063 active site 748449006064 NTP binding site [chemical binding]; other site 748449006065 metal binding triad [ion binding]; metal-binding site 748449006066 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 748449006067 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 748449006068 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 748449006069 metal binding site 2 [ion binding]; metal-binding site 748449006070 putative DNA binding helix; other site 748449006071 metal binding site 1 [ion binding]; metal-binding site 748449006072 dimer interface [polypeptide binding]; other site 748449006073 structural Zn2+ binding site [ion binding]; other site 748449006074 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 748449006075 nickel binding site [ion binding]; other site 748449006076 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 748449006077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449006078 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 748449006079 active pocket/dimerization site; other site 748449006080 active site 748449006081 phosphorylation site [posttranslational modification] 748449006082 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 748449006083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449006084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748449006085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449006086 Predicted dehydrogenase [General function prediction only]; Region: COG0579 748449006087 hydroxyglutarate oxidase; Provisional; Region: PRK11728 748449006088 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 748449006089 glycerol kinase; Provisional; Region: glpK; PRK00047 748449006090 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 748449006091 N- and C-terminal domain interface [polypeptide binding]; other site 748449006092 active site 748449006093 MgATP binding site [chemical binding]; other site 748449006094 catalytic site [active] 748449006095 metal binding site [ion binding]; metal-binding site 748449006096 glycerol binding site [chemical binding]; other site 748449006097 homotetramer interface [polypeptide binding]; other site 748449006098 homodimer interface [polypeptide binding]; other site 748449006099 FBP binding site [chemical binding]; other site 748449006100 protein IIAGlc interface [polypeptide binding]; other site 748449006101 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 748449006102 amphipathic channel; other site 748449006103 Asn-Pro-Ala signature motifs; other site 748449006104 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 748449006105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449006106 dimer interface [polypeptide binding]; other site 748449006107 conserved gate region; other site 748449006108 putative PBP binding loops; other site 748449006109 ABC-ATPase subunit interface; other site 748449006110 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 748449006111 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 748449006112 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 748449006113 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 748449006114 Walker A/P-loop; other site 748449006115 ATP binding site [chemical binding]; other site 748449006116 Q-loop/lid; other site 748449006117 ABC transporter signature motif; other site 748449006118 Walker B; other site 748449006119 D-loop; other site 748449006120 H-loop/switch region; other site 748449006121 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 748449006122 sporulation sigma factor SigK; Reviewed; Region: PRK05803 748449006123 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449006124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449006125 DNA binding residues [nucleotide binding] 748449006126 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 748449006127 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 748449006128 Sugar specificity; other site 748449006129 Pyrimidine base specificity; other site 748449006130 ATP-binding site [chemical binding]; other site 748449006131 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 748449006132 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 748449006133 Peptidase family U32; Region: Peptidase_U32; pfam01136 748449006134 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 748449006135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449006136 S-adenosylmethionine binding site [chemical binding]; other site 748449006137 YceG-like family; Region: YceG; pfam02618 748449006138 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 748449006139 dimerization interface [polypeptide binding]; other site 748449006140 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 748449006141 cell division protein FtsA; Region: ftsA; TIGR01174 748449006142 Cell division protein FtsA; Region: FtsA; cl17206 748449006143 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 748449006144 hypothetical protein; Provisional; Region: PRK05473 748449006145 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 748449006146 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 748449006147 motif 1; other site 748449006148 active site 748449006149 motif 2; other site 748449006150 motif 3; other site 748449006151 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 748449006152 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 748449006153 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 748449006154 Domain of unknown function DUF20; Region: UPF0118; pfam01594 748449006155 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 748449006156 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 748449006157 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 748449006158 active site 748449006159 HIGH motif; other site 748449006160 dimer interface [polypeptide binding]; other site 748449006161 KMSKS motif; other site 748449006162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748449006163 RNA binding surface [nucleotide binding]; other site 748449006164 Transglycosylase; Region: Transgly; pfam00912 748449006165 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 748449006166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748449006167 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 748449006168 MutS domain III; Region: MutS_III; pfam05192 748449006169 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 748449006170 Walker A/P-loop; other site 748449006171 ATP binding site [chemical binding]; other site 748449006172 Q-loop/lid; other site 748449006173 ABC transporter signature motif; other site 748449006174 Walker B; other site 748449006175 D-loop; other site 748449006176 H-loop/switch region; other site 748449006177 Smr domain; Region: Smr; pfam01713 748449006178 Uncharacterized conserved protein [Function unknown]; Region: COG0327 748449006179 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 748449006180 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 748449006181 S1 domain; Region: S1_2; pfam13509 748449006182 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 748449006183 Cell division protein ZapA; Region: ZapA; cl01146 748449006184 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 748449006185 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 748449006186 putative tRNA-binding site [nucleotide binding]; other site 748449006187 B3/4 domain; Region: B3_4; pfam03483 748449006188 tRNA synthetase B5 domain; Region: B5; smart00874 748449006189 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 748449006190 dimer interface [polypeptide binding]; other site 748449006191 motif 1; other site 748449006192 motif 3; other site 748449006193 motif 2; other site 748449006194 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 748449006195 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 748449006196 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 748449006197 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 748449006198 dimer interface [polypeptide binding]; other site 748449006199 motif 1; other site 748449006200 active site 748449006201 motif 2; other site 748449006202 motif 3; other site 748449006203 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 748449006204 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 748449006205 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 748449006206 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 748449006207 TrkA-N domain; Region: TrkA_N; pfam02254 748449006208 TrkA-C domain; Region: TrkA_C; pfam02080 748449006209 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 748449006210 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 748449006211 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 748449006212 TrkA-N domain; Region: TrkA_N; pfam02254 748449006213 TrkA-C domain; Region: TrkA_C; pfam02080 748449006214 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 748449006215 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 748449006216 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 748449006217 23S rRNA binding site [nucleotide binding]; other site 748449006218 L21 binding site [polypeptide binding]; other site 748449006219 L13 binding site [polypeptide binding]; other site 748449006220 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 748449006221 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 748449006222 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 748449006223 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 748449006224 Ribosomal protein L20 leader; Halha_2096 748449006225 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 748449006226 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 748449006227 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 748449006228 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 748449006229 active site 748449006230 dimer interface [polypeptide binding]; other site 748449006231 motif 1; other site 748449006232 motif 2; other site 748449006233 motif 3; other site 748449006234 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 748449006235 anticodon binding site; other site 748449006236 YtxC-like family; Region: YtxC; pfam08812 748449006237 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 748449006238 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 748449006239 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 748449006240 SmpB-tmRNA interface; other site 748449006241 ribonuclease R; Region: RNase_R; TIGR02063 748449006242 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 748449006243 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 748449006244 RNB domain; Region: RNB; pfam00773 748449006245 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 748449006246 RNA binding site [nucleotide binding]; other site 748449006247 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 748449006248 enolase; Provisional; Region: eno; PRK00077 748449006249 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 748449006250 dimer interface [polypeptide binding]; other site 748449006251 metal binding site [ion binding]; metal-binding site 748449006252 substrate binding pocket [chemical binding]; other site 748449006253 phosphoglyceromutase; Provisional; Region: PRK05434 748449006254 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 748449006255 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 748449006256 triosephosphate isomerase; Provisional; Region: PRK14567 748449006257 substrate binding site [chemical binding]; other site 748449006258 dimer interface [polypeptide binding]; other site 748449006259 catalytic triad [active] 748449006260 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 748449006261 Phosphoglycerate kinase; Region: PGK; pfam00162 748449006262 substrate binding site [chemical binding]; other site 748449006263 hinge regions; other site 748449006264 ADP binding site [chemical binding]; other site 748449006265 catalytic site [active] 748449006266 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 748449006267 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 748449006268 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 748449006269 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 748449006270 Predicted transcriptional regulator [Transcription]; Region: COG3388 748449006271 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 748449006272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 748449006273 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 748449006274 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 748449006275 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 748449006276 phosphate binding site [ion binding]; other site 748449006277 putative substrate binding pocket [chemical binding]; other site 748449006278 dimer interface [polypeptide binding]; other site 748449006279 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 748449006280 AAA domain; Region: AAA_18; pfam13238 748449006281 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 748449006282 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 748449006283 active site 748449006284 putative hydrolase; Validated; Region: PRK09248 748449006285 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 748449006286 active site 748449006287 Carbohydrate binding domain; Region: CBM_25; smart01066 748449006288 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 748449006289 putative ligand binding site [chemical binding]; other site 748449006290 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 748449006291 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 748449006292 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 748449006293 active site 748449006294 homodimer interface [polypeptide binding]; other site 748449006295 catalytic site [active] 748449006296 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748449006297 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 748449006298 hexamer interface [polypeptide binding]; other site 748449006299 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cl07944 748449006300 RNA binding site [nucleotide binding]; other site 748449006301 Histidine-zinc binding site [chemical binding]; other site 748449006302 HPr kinase/phosphorylase; Provisional; Region: PRK05428 748449006303 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 748449006304 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 748449006305 Hpr binding site; other site 748449006306 active site 748449006307 homohexamer subunit interaction site [polypeptide binding]; other site 748449006308 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 748449006309 methionine cluster; other site 748449006310 active site 748449006311 phosphorylation site [posttranslational modification] 748449006312 metal binding site [ion binding]; metal-binding site 748449006313 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 748449006314 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748449006315 nucleotide binding site [chemical binding]; other site 748449006316 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 748449006317 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 748449006318 active site 748449006319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449006320 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748449006321 active site 748449006322 motif I; other site 748449006323 motif II; other site 748449006324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449006325 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 748449006326 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 748449006327 putative homodimer interface [polypeptide binding]; other site 748449006328 putative homotetramer interface [polypeptide binding]; other site 748449006329 putative allosteric switch controlling residues; other site 748449006330 putative metal binding site [ion binding]; other site 748449006331 putative homodimer-homodimer interface [polypeptide binding]; other site 748449006332 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 748449006333 metal-binding site [ion binding] 748449006334 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 748449006335 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 748449006336 GIY-YIG motif/motif A; other site 748449006337 active site 748449006338 catalytic site [active] 748449006339 putative DNA binding site [nucleotide binding]; other site 748449006340 metal binding site [ion binding]; metal-binding site 748449006341 UvrB/uvrC motif; Region: UVR; pfam02151 748449006342 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 748449006343 Helix-hairpin-helix motif; Region: HHH; pfam00633 748449006344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748449006345 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 748449006346 putative active site [active] 748449006347 heme pocket [chemical binding]; other site 748449006348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748449006349 dimer interface [polypeptide binding]; other site 748449006350 phosphorylation site [posttranslational modification] 748449006351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449006352 ATP binding site [chemical binding]; other site 748449006353 Mg2+ binding site [ion binding]; other site 748449006354 G-X-G motif; other site 748449006355 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748449006356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748449006357 non-specific DNA binding site [nucleotide binding]; other site 748449006358 salt bridge; other site 748449006359 sequence-specific DNA binding site [nucleotide binding]; other site 748449006360 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 748449006361 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 748449006362 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 748449006363 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 748449006364 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 748449006365 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 748449006366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449006367 catalytic residue [active] 748449006368 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 748449006369 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748449006370 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 748449006371 HTH domain; Region: HTH_11; pfam08279 748449006372 Mga helix-turn-helix domain; Region: Mga; pfam05043 748449006373 PRD domain; Region: PRD; pfam00874 748449006374 PRD domain; Region: PRD; pfam00874 748449006375 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 748449006376 active site 748449006377 P-loop; other site 748449006378 phosphorylation site [posttranslational modification] 748449006379 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748449006380 active site 748449006381 phosphorylation site [posttranslational modification] 748449006382 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 748449006383 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 748449006384 active site 748449006385 P-loop; other site 748449006386 phosphorylation site [posttranslational modification] 748449006387 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748449006388 active site 748449006389 phosphorylation site [posttranslational modification] 748449006390 Predicted membrane protein [Function unknown]; Region: COG3462 748449006391 Short C-terminal domain; Region: SHOCT; pfam09851 748449006392 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 748449006393 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 748449006394 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 748449006395 GIY-YIG motif/motif A; other site 748449006396 active site 748449006397 catalytic site [active] 748449006398 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 748449006399 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 748449006400 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 748449006401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748449006402 catalytic residue [active] 748449006403 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 748449006404 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 748449006405 Active Sites [active] 748449006406 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748449006407 AAA domain; Region: AAA_23; pfam13476 748449006408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449006409 Walker A/P-loop; other site 748449006410 ATP binding site [chemical binding]; other site 748449006411 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 748449006412 PLD-like domain; Region: PLDc_2; pfam13091 748449006413 putative active site [active] 748449006414 catalytic site [active] 748449006415 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 748449006416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449006417 ATP binding site [chemical binding]; other site 748449006418 putative Mg++ binding site [ion binding]; other site 748449006419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449006420 nucleotide binding region [chemical binding]; other site 748449006421 ATP-binding site [chemical binding]; other site 748449006422 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 748449006423 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 748449006424 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 748449006425 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 748449006426 Holin family; Region: Phage_holin_4; pfam05105 748449006427 flagellar capping protein; Reviewed; Region: fliD; PRK08032 748449006428 hypothetical protein; Validated; Region: PRK08116 748449006429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 748449006430 Helix-turn-helix domain; Region: HTH_17; pfam12728 748449006431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 748449006432 salt bridge; other site 748449006433 non-specific DNA binding site [nucleotide binding]; other site 748449006434 sequence-specific DNA binding site [nucleotide binding]; other site 748449006435 Domain of unknown function (DUF955); Region: DUF955; pfam06114 748449006436 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 748449006437 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 748449006438 Int/Topo IB signature motif; other site 748449006439 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 748449006440 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 748449006441 G1 box; other site 748449006442 putative GEF interaction site [polypeptide binding]; other site 748449006443 GTP/Mg2+ binding site [chemical binding]; other site 748449006444 Switch I region; other site 748449006445 G2 box; other site 748449006446 G3 box; other site 748449006447 Switch II region; other site 748449006448 G4 box; other site 748449006449 G5 box; other site 748449006450 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 748449006451 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 748449006452 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 748449006453 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 748449006454 selenocysteine synthase; Provisional; Region: PRK04311 748449006455 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 748449006456 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 748449006457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748449006458 catalytic residue [active] 748449006459 catalytic residue [active] 748449006460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748449006461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748449006462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748449006463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748449006464 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 748449006465 putative dimerization interface [polypeptide binding]; other site 748449006466 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 748449006467 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 748449006468 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748449006469 catalytic residue [active] 748449006470 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 748449006471 active site residue [active] 748449006472 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 748449006473 active site residue [active] 748449006474 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 748449006475 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 748449006476 active site residue [active] 748449006477 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 748449006478 active site residue [active] 748449006479 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 748449006480 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 748449006481 CPxP motif; other site 748449006482 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 748449006483 active site residue [active] 748449006484 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 748449006485 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 748449006486 active site residue [active] 748449006487 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 748449006488 active site residue [active] 748449006489 Cache domain; Region: Cache_1; pfam02743 748449006490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449006491 dimerization interface [polypeptide binding]; other site 748449006492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449006493 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449006494 dimer interface [polypeptide binding]; other site 748449006495 putative CheW interface [polypeptide binding]; other site 748449006496 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 748449006497 propionate/acetate kinase; Provisional; Region: PRK12379 748449006498 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 748449006499 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 748449006500 dimer interface [polypeptide binding]; other site 748449006501 active site 748449006502 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748449006503 catalytic residues [active] 748449006504 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 748449006505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449006506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449006507 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748449006508 catalytic residues [active] 748449006509 BCCT family transporter; Region: BCCT; pfam02028 748449006510 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 748449006511 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 748449006512 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 748449006513 Ferredoxin [Energy production and conversion]; Region: COG1146 748449006514 4Fe-4S binding domain; Region: Fer4_6; pfam12837 748449006515 excinuclease ABC subunit B; Provisional; Region: PRK05298 748449006516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449006517 ATP binding site [chemical binding]; other site 748449006518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449006519 nucleotide binding region [chemical binding]; other site 748449006520 ATP-binding site [chemical binding]; other site 748449006521 Ultra-violet resistance protein B; Region: UvrB; pfam12344 748449006522 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 748449006523 NodB motif; other site 748449006524 putative active site [active] 748449006525 putative catalytic site [active] 748449006526 Zn binding site [ion binding]; other site 748449006527 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 748449006528 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 748449006529 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 748449006530 protein binding site [polypeptide binding]; other site 748449006531 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 748449006532 Catalytic dyad [active] 748449006533 ATP cone domain; Region: ATP-cone; pfam03477 748449006534 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 748449006535 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 748449006536 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 748449006537 intein N-terminal splicing region; Region: intein_Nterm; TIGR01445 748449006538 protein-splicing catalytic site; other site 748449006539 thioester formation/cholesterol transfer; other site 748449006540 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 748449006541 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 748449006542 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 748449006543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449006544 FeS/SAM binding site; other site 748449006545 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 748449006546 Predicted permeases [General function prediction only]; Region: COG0701 748449006547 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 748449006548 Sodium Bile acid symporter family; Region: SBF; cl17470 748449006549 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 748449006550 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748449006551 active site 748449006552 metal binding site [ion binding]; metal-binding site 748449006553 homotetramer interface [polypeptide binding]; other site 748449006554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748449006555 dimerization interface [polypeptide binding]; other site 748449006556 putative DNA binding site [nucleotide binding]; other site 748449006557 putative Zn2+ binding site [ion binding]; other site 748449006558 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 748449006559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748449006560 DNA-binding site [nucleotide binding]; DNA binding site 748449006561 UTRA domain; Region: UTRA; pfam07702 748449006562 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 748449006563 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 748449006564 Ca binding site [ion binding]; other site 748449006565 active site 748449006566 catalytic site [active] 748449006567 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 748449006568 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748449006569 active site turn [active] 748449006570 phosphorylation site [posttranslational modification] 748449006571 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748449006572 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449006573 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449006574 putative active site [active] 748449006575 putative NTP binding site [chemical binding]; other site 748449006576 putative nucleic acid binding site [nucleotide binding]; other site 748449006577 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449006578 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 748449006579 intersubunit interface [polypeptide binding]; other site 748449006580 active site 748449006581 catalytic residue [active] 748449006582 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 748449006583 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 748449006584 PYR/PP interface [polypeptide binding]; other site 748449006585 dimer interface [polypeptide binding]; other site 748449006586 TPP binding site [chemical binding]; other site 748449006587 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 748449006588 transketolase; Reviewed; Region: PRK05899 748449006589 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 748449006590 TPP-binding site [chemical binding]; other site 748449006591 dimer interface [polypeptide binding]; other site 748449006592 Uncharacterized conserved protein [Function unknown]; Region: COG1284 748449006593 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748449006594 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748449006595 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 748449006596 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 748449006597 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 748449006598 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 748449006599 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 748449006600 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 748449006601 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 748449006602 peptide chain release factor 2; Validated; Region: prfB; PRK00578 748449006603 This domain is found in peptide chain release factors; Region: PCRF; smart00937 748449006604 RF-1 domain; Region: RF-1; pfam00472 748449006605 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 748449006606 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449006607 ATP binding site [chemical binding]; other site 748449006608 putative Mg++ binding site [ion binding]; other site 748449006609 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 748449006610 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 748449006611 nucleotide binding region [chemical binding]; other site 748449006612 ATP-binding site [chemical binding]; other site 748449006613 SEC-C motif; Region: SEC-C; pfam02810 748449006614 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 748449006615 30S subunit binding site; other site 748449006616 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 748449006617 DNA-binding site [nucleotide binding]; DNA binding site 748449006618 RNA-binding motif; other site 748449006619 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748449006620 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 748449006621 Walker A/P-loop; other site 748449006622 ATP binding site [chemical binding]; other site 748449006623 Q-loop/lid; other site 748449006624 ABC transporter signature motif; other site 748449006625 Walker B; other site 748449006626 D-loop; other site 748449006627 H-loop/switch region; other site 748449006628 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 748449006629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449006630 dimer interface [polypeptide binding]; other site 748449006631 conserved gate region; other site 748449006632 putative PBP binding loops; other site 748449006633 ABC-ATPase subunit interface; other site 748449006634 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748449006635 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748449006636 substrate binding pocket [chemical binding]; other site 748449006637 membrane-bound complex binding site; other site 748449006638 hinge residues; other site 748449006639 FlaG protein; Region: FlaG; pfam03646 748449006640 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 748449006641 active site 748449006642 cosubstrate binding site; other site 748449006643 substrate binding site [chemical binding]; other site 748449006644 catalytic site [active] 748449006645 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 748449006646 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 748449006647 metal binding site [ion binding]; metal-binding site 748449006648 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 748449006649 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748449006650 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 748449006651 ligand binding site; other site 748449006652 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 748449006653 NeuB family; Region: NeuB; pfam03102 748449006654 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 748449006655 NeuB binding interface [polypeptide binding]; other site 748449006656 putative substrate binding site [chemical binding]; other site 748449006657 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 748449006658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449006659 motif II; other site 748449006660 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 748449006661 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 748449006662 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 748449006663 NADP binding site [chemical binding]; other site 748449006664 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 748449006665 active site 748449006666 putative substrate binding site [chemical binding]; other site 748449006667 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 748449006668 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 748449006669 NAD binding site [chemical binding]; other site 748449006670 substrate binding site [chemical binding]; other site 748449006671 homodimer interface [polypeptide binding]; other site 748449006672 active site 748449006673 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 748449006674 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 748449006675 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 748449006676 substrate binding site; other site 748449006677 tetramer interface; other site 748449006678 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 748449006679 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748449006680 active site 748449006681 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 748449006682 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 748449006683 active site 748449006684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449006685 binding surface 748449006686 TPR repeat; Region: TPR_11; pfam13414 748449006687 TPR motif; other site 748449006688 TPR repeat; Region: TPR_11; pfam13414 748449006689 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 748449006690 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748449006691 active site 748449006692 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748449006693 Transposase; Region: HTH_Tnp_1; pfam01527 748449006694 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 748449006695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748449006696 active site 748449006697 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 748449006698 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 748449006699 inhibitor-cofactor binding pocket; inhibition site 748449006700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449006701 catalytic residue [active] 748449006702 Methyltransferase domain; Region: Methyltransf_23; pfam13489 748449006703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449006704 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 748449006705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 748449006706 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 748449006707 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 748449006708 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 748449006709 inhibitor-cofactor binding pocket; inhibition site 748449006710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449006711 catalytic residue [active] 748449006712 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 748449006713 four helix bundle protein; Region: TIGR02436 748449006714 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 748449006715 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 748449006716 NAD(P) binding site [chemical binding]; other site 748449006717 homodimer interface [polypeptide binding]; other site 748449006718 substrate binding site [chemical binding]; other site 748449006719 active site 748449006720 Flagellar protein FliS; Region: FliS; cl00654 748449006721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 748449006722 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 748449006723 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 748449006724 flagellin; Reviewed; Region: PRK08869 748449006725 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 748449006726 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 748449006727 carbon storage regulator; Provisional; Region: PRK01712 748449006728 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 748449006729 four helix bundle protein; Region: TIGR02436 748449006730 flagellar assembly protein FliW; Provisional; Region: PRK13285 748449006731 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 748449006732 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 748449006733 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 748449006734 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 748449006735 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 748449006736 FlgN protein; Region: FlgN; pfam05130 748449006737 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 748449006738 flagellar operon protein TIGR03826; Region: YvyF 748449006739 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 748449006740 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748449006741 active site 748449006742 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 748449006743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748449006744 ATP binding site [chemical binding]; other site 748449006745 putative Mg++ binding site [ion binding]; other site 748449006746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748449006747 nucleotide binding region [chemical binding]; other site 748449006748 ATP-binding site [chemical binding]; other site 748449006749 RNA polymerase factor sigma-70; Validated; Region: PRK08295 748449006750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449006751 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 748449006752 DNA binding residues [nucleotide binding] 748449006753 Uncharacterized conserved protein [Function unknown]; Region: COG2006 748449006754 Domain of unknown function (DUF362); Region: DUF362; pfam04015 748449006755 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748449006756 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 748449006757 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 748449006758 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 748449006759 catalytic loop [active] 748449006760 iron binding site [ion binding]; other site 748449006761 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 748449006762 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 748449006763 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 748449006764 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 748449006765 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 748449006766 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 748449006767 dimer interface [polypeptide binding]; other site 748449006768 [2Fe-2S] cluster binding site [ion binding]; other site 748449006769 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 748449006770 SLBB domain; Region: SLBB; pfam10531 748449006771 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 748449006772 4Fe-4S binding domain; Region: Fer4; pfam00037 748449006773 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 748449006774 4Fe-4S binding domain; Region: Fer4; pfam00037 748449006775 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 748449006776 dimer interface [polypeptide binding]; other site 748449006777 [2Fe-2S] cluster binding site [ion binding]; other site 748449006778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748449006779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449006780 ATP binding site [chemical binding]; other site 748449006781 Mg2+ binding site [ion binding]; other site 748449006782 G-X-G motif; other site 748449006783 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 748449006784 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 748449006785 putative dimer interface [polypeptide binding]; other site 748449006786 [2Fe-2S] cluster binding site [ion binding]; other site 748449006787 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 748449006788 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 748449006789 active site 748449006790 nucleotide binding site [chemical binding]; other site 748449006791 HIGH motif; other site 748449006792 KMSKS motif; other site 748449006793 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 748449006794 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 748449006795 putative ribose interaction site [chemical binding]; other site 748449006796 putative ADP binding site [chemical binding]; other site 748449006797 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 748449006798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449006799 active site 748449006800 motif I; other site 748449006801 motif II; other site 748449006802 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 748449006803 dimerization domain swap beta strand [polypeptide binding]; other site 748449006804 regulatory protein interface [polypeptide binding]; other site 748449006805 active site 748449006806 regulatory phosphorylation site [posttranslational modification]; other site 748449006807 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 748449006808 GAF domain; Region: GAF_2; pfam13185 748449006809 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 748449006810 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 748449006811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449006812 S-adenosylmethionine binding site [chemical binding]; other site 748449006813 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 748449006814 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 748449006815 tartrate dehydrogenase; Region: TTC; TIGR02089 748449006816 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 748449006817 Citrate synthase; Region: Citrate_synt; pfam00285 748449006818 oxalacetate binding site [chemical binding]; other site 748449006819 citrylCoA binding site [chemical binding]; other site 748449006820 coenzyme A binding site [chemical binding]; other site 748449006821 catalytic triad [active] 748449006822 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 748449006823 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 748449006824 GatB domain; Region: GatB_Yqey; smart00845 748449006825 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 748449006826 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 748449006827 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 748449006828 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 748449006829 active site 748449006830 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 748449006831 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 748449006832 nucleotide binding pocket [chemical binding]; other site 748449006833 K-X-D-G motif; other site 748449006834 catalytic site [active] 748449006835 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 748449006836 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 748449006837 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 748449006838 Dimer interface [polypeptide binding]; other site 748449006839 BRCT sequence motif; other site 748449006840 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 748449006841 TrkA-N domain; Region: TrkA_N; pfam02254 748449006842 TrkA-C domain; Region: TrkA_C; pfam02080 748449006843 Rubrerythrin [Energy production and conversion]; Region: COG1592 748449006844 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 748449006845 diiron binding motif [ion binding]; other site 748449006846 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 748449006847 DHH family; Region: DHH; pfam01368 748449006848 DHHA2 domain; Region: DHHA2; pfam02833 748449006849 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 748449006850 Part of AAA domain; Region: AAA_19; pfam13245 748449006851 Family description; Region: UvrD_C_2; pfam13538 748449006852 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 748449006853 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 748449006854 catalytic residues [active] 748449006855 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 748449006856 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 748449006857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449006858 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 748449006859 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 748449006860 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 748449006861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449006862 dimer interface [polypeptide binding]; other site 748449006863 conserved gate region; other site 748449006864 ABC-ATPase subunit interface; other site 748449006865 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 748449006866 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 748449006867 Walker A/P-loop; other site 748449006868 ATP binding site [chemical binding]; other site 748449006869 Q-loop/lid; other site 748449006870 ABC transporter signature motif; other site 748449006871 Walker B; other site 748449006872 D-loop; other site 748449006873 H-loop/switch region; other site 748449006874 NIL domain; Region: NIL; pfam09383 748449006875 TSCPD domain; Region: TSCPD; cl14834 748449006876 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 748449006877 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 748449006878 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 748449006879 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 748449006880 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 748449006881 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 748449006882 active site 748449006883 P-loop; other site 748449006884 phosphorylation site [posttranslational modification] 748449006885 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748449006886 active site 748449006887 phosphorylation site [posttranslational modification] 748449006888 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 748449006889 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 748449006890 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 748449006891 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 748449006892 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 748449006893 substrate binding site [chemical binding]; other site 748449006894 hexamer interface [polypeptide binding]; other site 748449006895 metal binding site [ion binding]; metal-binding site 748449006896 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 748449006897 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 748449006898 TPP-binding site [chemical binding]; other site 748449006899 dimer interface [polypeptide binding]; other site 748449006900 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 748449006901 PYR/PP interface [polypeptide binding]; other site 748449006902 dimer interface [polypeptide binding]; other site 748449006903 TPP binding site [chemical binding]; other site 748449006904 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 748449006905 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 748449006906 active site 748449006907 intersubunit interactions; other site 748449006908 catalytic residue [active] 748449006909 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 748449006910 tetramer interface [polypeptide binding]; other site 748449006911 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 748449006912 active site 748449006913 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 748449006914 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 748449006915 substrate binding site [chemical binding]; other site 748449006916 hexamer interface [polypeptide binding]; other site 748449006917 metal binding site [ion binding]; metal-binding site 748449006918 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 748449006919 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 748449006920 siderophore binding site; other site 748449006921 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 748449006922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748449006923 ABC-ATPase subunit interface; other site 748449006924 dimer interface [polypeptide binding]; other site 748449006925 putative PBP binding regions; other site 748449006926 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 748449006927 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748449006928 ABC-ATPase subunit interface; other site 748449006929 dimer interface [polypeptide binding]; other site 748449006930 putative PBP binding regions; other site 748449006931 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748449006932 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 748449006933 Walker A/P-loop; other site 748449006934 ATP binding site [chemical binding]; other site 748449006935 Q-loop/lid; other site 748449006936 ABC transporter signature motif; other site 748449006937 Walker B; other site 748449006938 D-loop; other site 748449006939 H-loop/switch region; other site 748449006940 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 748449006941 classical (c) SDRs; Region: SDR_c; cd05233 748449006942 NAD(P) binding site [chemical binding]; other site 748449006943 active site 748449006944 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 748449006945 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748449006946 metal-binding site [ion binding] 748449006947 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748449006948 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 748449006949 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748449006950 dimerization interface [polypeptide binding]; other site 748449006951 putative DNA binding site [nucleotide binding]; other site 748449006952 putative Zn2+ binding site [ion binding]; other site 748449006953 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 748449006954 Peptidase family M23; Region: Peptidase_M23; pfam01551 748449006955 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 748449006956 Ferredoxin [Energy production and conversion]; Region: COG1146 748449006957 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 748449006958 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 748449006959 L-aspartate oxidase; Provisional; Region: PRK06175 748449006960 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 748449006961 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 748449006962 ATP-sulfurylase; Region: ATPS; cd00517 748449006963 active site 748449006964 HXXH motif; other site 748449006965 flexible loop; other site 748449006966 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 748449006967 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 748449006968 homodimer interface [polypeptide binding]; other site 748449006969 substrate-cofactor binding pocket; other site 748449006970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449006971 catalytic residue [active] 748449006972 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 748449006973 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 748449006974 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 748449006975 CPxP motif; other site 748449006976 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 748449006977 MPN+ (JAMM) motif; other site 748449006978 Zinc-binding site [ion binding]; other site 748449006979 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 748449006980 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 748449006981 ATP binding site [chemical binding]; other site 748449006982 substrate interface [chemical binding]; other site 748449006983 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 748449006984 thiS-thiF/thiG interaction site; other site 748449006985 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 748449006986 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 748449006987 dimer interface [polypeptide binding]; other site 748449006988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449006989 catalytic residue [active] 748449006990 Domain of unknown function (DUF389); Region: DUF389; pfam04087 748449006991 Trp repressor protein; Region: Trp_repressor; cl17266 748449006992 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748449006993 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 748449006994 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 748449006995 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 748449006996 C-terminal domain interface [polypeptide binding]; other site 748449006997 GSH binding site (G-site) [chemical binding]; other site 748449006998 dimer interface [polypeptide binding]; other site 748449006999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748449007000 dimerization interface [polypeptide binding]; other site 748449007001 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 748449007002 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 748449007003 dimer interface [polypeptide binding]; other site 748449007004 putative CheW interface [polypeptide binding]; other site 748449007005 Hemerythrin; Region: Hemerythrin; cd12107 748449007006 Fe binding site [ion binding]; other site 748449007007 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 748449007008 FO synthase subunit 2; Reviewed; Region: PRK07360 748449007009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449007010 FeS/SAM binding site; other site 748449007011 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 748449007012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449007013 FeS/SAM binding site; other site 748449007014 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 748449007015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748449007016 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748449007017 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 748449007018 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 748449007019 active site residue [active] 748449007020 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 748449007021 CPxP motif; other site 748449007022 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 748449007023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748449007024 putative DNA binding site [nucleotide binding]; other site 748449007025 putative Zn2+ binding site [ion binding]; other site 748449007026 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 748449007027 Cna protein B-type domain; Region: Cna_B_2; pfam13715 748449007028 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 748449007029 LPP20 lipoprotein; Region: LPP20; cl15824 748449007030 LPP20 lipoprotein; Region: LPP20; pfam02169 748449007031 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 748449007032 Tetratricopeptide repeat; Region: TPR_16; pfam13432 748449007033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449007034 binding surface 748449007035 Tetratricopeptide repeat; Region: TPR_16; pfam13432 748449007036 TPR motif; other site 748449007037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 748449007038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748449007039 binding surface 748449007040 TPR motif; other site 748449007041 Tetratricopeptide repeat; Region: TPR_16; pfam13432 748449007042 Stage II sporulation protein; Region: SpoIID; pfam08486 748449007043 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 748449007044 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 748449007045 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 748449007046 active site 748449007047 tetramer interface; other site 748449007048 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 748449007049 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 748449007050 active site 748449007051 homodimer interface [polypeptide binding]; other site 748449007052 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 748449007053 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 748449007054 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 748449007055 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 748449007056 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 748449007057 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 748449007058 active site 748449007059 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 748449007060 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 748449007061 ligand-binding site [chemical binding]; other site 748449007062 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 748449007063 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 748449007064 CysD dimerization site [polypeptide binding]; other site 748449007065 G1 box; other site 748449007066 putative GEF interaction site [polypeptide binding]; other site 748449007067 GTP/Mg2+ binding site [chemical binding]; other site 748449007068 Switch I region; other site 748449007069 G2 box; other site 748449007070 G3 box; other site 748449007071 Switch II region; other site 748449007072 G4 box; other site 748449007073 G5 box; other site 748449007074 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 748449007075 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 748449007076 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 748449007077 active site 748449007078 Uncharacterized conserved protein [Function unknown]; Region: COG2445 748449007079 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 748449007080 active site 748449007081 NTP binding site [chemical binding]; other site 748449007082 metal binding triad [ion binding]; metal-binding site 748449007083 antibiotic binding site [chemical binding]; other site 748449007084 Domain of unknown function (DUF955); Region: DUF955; cl01076 748449007085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748449007086 non-specific DNA binding site [nucleotide binding]; other site 748449007087 salt bridge; other site 748449007088 sequence-specific DNA binding site [nucleotide binding]; other site 748449007089 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 748449007090 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 748449007091 Active Sites [active] 748449007092 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 748449007093 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 748449007094 NAD binding site [chemical binding]; other site 748449007095 substrate binding site [chemical binding]; other site 748449007096 homodimer interface [polypeptide binding]; other site 748449007097 active site 748449007098 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 748449007099 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 748449007100 NADP binding site [chemical binding]; other site 748449007101 active site 748449007102 putative substrate binding site [chemical binding]; other site 748449007103 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 748449007104 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 748449007105 NAD binding site [chemical binding]; other site 748449007106 substrate binding site [chemical binding]; other site 748449007107 homodimer interface [polypeptide binding]; other site 748449007108 active site 748449007109 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 748449007110 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 748449007111 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 748449007112 substrate binding site; other site 748449007113 tetramer interface; other site 748449007114 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 748449007115 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 748449007116 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748449007117 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 748449007118 O-Antigen ligase; Region: Wzy_C; pfam04932 748449007119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748449007120 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 748449007121 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 748449007122 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 748449007123 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 748449007124 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 748449007125 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 748449007126 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 748449007127 NAD binding site [chemical binding]; other site 748449007128 homodimer interface [polypeptide binding]; other site 748449007129 active site 748449007130 substrate binding site [chemical binding]; other site 748449007131 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 748449007132 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 748449007133 Substrate binding site; other site 748449007134 Cupin domain; Region: Cupin_2; cl17218 748449007135 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 748449007136 Bacterial sugar transferase; Region: Bac_transf; pfam02397 748449007137 Chain length determinant protein; Region: Wzz; cl15801 748449007138 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 748449007139 active site 748449007140 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748449007141 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748449007142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748449007143 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 748449007144 O-Antigen ligase; Region: Wzy_C; pfam04932 748449007145 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748449007146 active site 748449007147 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 748449007148 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 748449007149 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748449007150 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 748449007151 putative ADP-binding pocket [chemical binding]; other site 748449007152 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 748449007153 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 748449007154 putative metal binding site; other site 748449007155 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748449007156 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 748449007157 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 748449007158 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 748449007159 putative active site [active] 748449007160 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 748449007161 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 748449007162 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 748449007163 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 748449007164 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 748449007165 putative active site [active] 748449007166 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 748449007167 OstA-like protein; Region: OstA; cl00844 748449007168 S-layer homology domain; Region: SLH; pfam00395 748449007169 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 748449007170 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 748449007171 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 748449007172 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 748449007173 Predicted permeases [General function prediction only]; Region: COG0795 748449007174 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 748449007175 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 748449007176 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 748449007177 Walker A/P-loop; other site 748449007178 ATP binding site [chemical binding]; other site 748449007179 Q-loop/lid; other site 748449007180 ABC transporter signature motif; other site 748449007181 Walker B; other site 748449007182 D-loop; other site 748449007183 H-loop/switch region; other site 748449007184 OstA-like protein; Region: OstA; cl00844 748449007185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 748449007186 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 748449007187 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 748449007188 putative acyl-acceptor binding pocket; other site 748449007189 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 748449007190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748449007191 active site 748449007192 motif I; other site 748449007193 motif II; other site 748449007194 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 748449007195 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 748449007196 putative active site [active] 748449007197 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 748449007198 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 748449007199 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 748449007200 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 748449007201 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 748449007202 Ligand binding site; other site 748449007203 oligomer interface; other site 748449007204 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 748449007205 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 748449007206 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 748449007207 putative acyl-acceptor binding pocket; other site 748449007208 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748449007209 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748449007210 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 748449007211 Walker A/P-loop; other site 748449007212 ATP binding site [chemical binding]; other site 748449007213 Q-loop/lid; other site 748449007214 ABC transporter signature motif; other site 748449007215 Walker B; other site 748449007216 D-loop; other site 748449007217 H-loop/switch region; other site 748449007218 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 748449007219 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 748449007220 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 748449007221 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 748449007222 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 748449007223 active site 748449007224 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 748449007225 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 748449007226 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 748449007227 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748449007228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449007229 Walker A/P-loop; other site 748449007230 ATP binding site [chemical binding]; other site 748449007231 Q-loop/lid; other site 748449007232 ABC transporter signature motif; other site 748449007233 Walker B; other site 748449007234 D-loop; other site 748449007235 H-loop/switch region; other site 748449007236 OstA-like protein; Region: OstA; cl00844 748449007237 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 748449007238 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 748449007239 OstA-like protein; Region: OstA; cl00844 748449007240 Predicted permeases [General function prediction only]; Region: COG0795 748449007241 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 748449007242 Predicted permeases [General function prediction only]; Region: COG0795 748449007243 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 748449007244 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 748449007245 active site 748449007246 catalytic triad [active] 748449007247 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748449007248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 748449007249 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 748449007250 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 748449007251 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 748449007252 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 748449007253 trimer interface [polypeptide binding]; other site 748449007254 active site 748449007255 UDP-GlcNAc binding site [chemical binding]; other site 748449007256 lipid binding site [chemical binding]; lipid-binding site 748449007257 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 748449007258 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 748449007259 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 748449007260 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 748449007261 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 748449007262 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 748449007263 Surface antigen; Region: Bac_surface_Ag; pfam01103 748449007264 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 748449007265 Family of unknown function (DUF490); Region: DUF490; pfam04357 748449007266 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 748449007267 Rod binding protein; Region: Rod-binding; cl01626 748449007268 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 748449007269 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 748449007270 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 748449007271 Flagellar L-ring protein; Region: FlgH; pfam02107 748449007272 SAF-like; Region: SAF_2; pfam13144 748449007273 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 748449007274 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 748449007275 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 748449007276 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 748449007277 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 748449007278 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 748449007279 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 748449007280 Stage III sporulation protein D; Region: SpoIIID; pfam12116 748449007281 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 748449007282 Peptidase family M23; Region: Peptidase_M23; pfam01551 748449007283 Stage II sporulation protein; Region: SpoIID; pfam08486 748449007284 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 748449007285 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 748449007286 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 748449007287 hinge; other site 748449007288 active site 748449007289 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 748449007290 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 748449007291 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 748449007292 gamma subunit interface [polypeptide binding]; other site 748449007293 epsilon subunit interface [polypeptide binding]; other site 748449007294 LBP interface [polypeptide binding]; other site 748449007295 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 748449007296 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 748449007297 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 748449007298 alpha subunit interaction interface [polypeptide binding]; other site 748449007299 Walker A motif; other site 748449007300 ATP binding site [chemical binding]; other site 748449007301 Walker B motif; other site 748449007302 inhibitor binding site; inhibition site 748449007303 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 748449007304 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 748449007305 core domain interface [polypeptide binding]; other site 748449007306 delta subunit interface [polypeptide binding]; other site 748449007307 epsilon subunit interface [polypeptide binding]; other site 748449007308 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 748449007309 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 748449007310 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 748449007311 beta subunit interaction interface [polypeptide binding]; other site 748449007312 Walker A motif; other site 748449007313 ATP binding site [chemical binding]; other site 748449007314 Walker B motif; other site 748449007315 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 748449007316 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 748449007317 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 748449007318 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 748449007319 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 748449007320 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 748449007321 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 748449007322 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 748449007323 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 748449007324 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 748449007325 ATP synthase I chain; Region: ATP_synt_I; pfam03899 748449007326 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 748449007327 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 748449007328 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 748449007329 Mg++ binding site [ion binding]; other site 748449007330 putative catalytic motif [active] 748449007331 substrate binding site [chemical binding]; other site 748449007332 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 748449007333 catalytic motif [active] 748449007334 Zn binding site [ion binding]; other site 748449007335 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748449007336 active site 748449007337 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 748449007338 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 748449007339 dimer interface [polypeptide binding]; other site 748449007340 active site 748449007341 glycine-pyridoxal phosphate binding site [chemical binding]; other site 748449007342 folate binding site [chemical binding]; other site 748449007343 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 748449007344 Low molecular weight phosphatase family; Region: LMWPc; cd00115 748449007345 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 748449007346 active site 748449007347 Domain of unknown function DUF; Region: DUF204; pfam02659 748449007348 Domain of unknown function DUF; Region: DUF204; pfam02659 748449007349 Domain of unknown function DUF; Region: DUF204; pfam02659 748449007350 Domain of unknown function DUF; Region: DUF204; pfam02659 748449007351 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 748449007352 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 748449007353 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 748449007354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449007355 S-adenosylmethionine binding site [chemical binding]; other site 748449007356 peptide chain release factor 1; Validated; Region: prfA; PRK00591 748449007357 This domain is found in peptide chain release factors; Region: PCRF; smart00937 748449007358 RF-1 domain; Region: RF-1; pfam00472 748449007359 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 748449007360 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 748449007361 transcription termination factor Rho; Provisional; Region: rho; PRK09376 748449007362 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 748449007363 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 748449007364 RNA binding site [nucleotide binding]; other site 748449007365 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 748449007366 Walker A motif; other site 748449007367 ATP binding site [chemical binding]; other site 748449007368 Walker B motif; other site 748449007369 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 748449007370 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 748449007371 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 748449007372 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 748449007373 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 748449007374 putative active site [active] 748449007375 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 748449007376 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 748449007377 intersubunit interface [polypeptide binding]; other site 748449007378 active site 748449007379 zinc binding site [ion binding]; other site 748449007380 Na+ binding site [ion binding]; other site 748449007381 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 748449007382 homotrimer interaction site [polypeptide binding]; other site 748449007383 putative active site [active] 748449007384 threonine dehydratase; Provisional; Region: PRK08198 748449007385 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 748449007386 tetramer interface [polypeptide binding]; other site 748449007387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748449007388 catalytic residue [active] 748449007389 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 748449007390 CTP synthetase; Validated; Region: pyrG; PRK05380 748449007391 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 748449007392 Catalytic site [active] 748449007393 active site 748449007394 UTP binding site [chemical binding]; other site 748449007395 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 748449007396 active site 748449007397 putative oxyanion hole; other site 748449007398 catalytic triad [active] 748449007399 XapX domain; Region: XapX; TIGR03510 748449007400 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 748449007401 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 748449007402 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 748449007403 active site 748449007404 HIGH motif; other site 748449007405 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748449007406 KMSK motif region; other site 748449007407 tRNA binding surface [nucleotide binding]; other site 748449007408 DALR anticodon binding domain; Region: DALR_1; smart00836 748449007409 anticodon binding site; other site 748449007410 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 748449007411 Protein of unknown function (DUF441); Region: DUF441; pfam04284 748449007412 isoaspartyl dipeptidase; Provisional; Region: PRK10657 748449007413 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748449007414 active site 748449007415 glutamine synthetase, type I; Region: GlnA; TIGR00653 748449007416 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 748449007417 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 748449007418 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 748449007419 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 748449007420 Predicted membrane protein [Function unknown]; Region: COG2323 748449007421 Membrane transport protein; Region: Mem_trans; cl09117 748449007422 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748449007423 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748449007424 DNA binding site [nucleotide binding] 748449007425 domain linker motif; other site 748449007426 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748449007427 dimerization interface [polypeptide binding]; other site 748449007428 ligand binding site [chemical binding]; other site 748449007429 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 748449007430 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 748449007431 tetrameric interface [polypeptide binding]; other site 748449007432 NAD binding site [chemical binding]; other site 748449007433 catalytic residues [active] 748449007434 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 748449007435 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 748449007436 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 748449007437 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 748449007438 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 748449007439 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 748449007440 PYR/PP interface [polypeptide binding]; other site 748449007441 dimer interface [polypeptide binding]; other site 748449007442 TPP binding site [chemical binding]; other site 748449007443 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 748449007444 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 748449007445 TPP-binding site; other site 748449007446 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 748449007447 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 748449007448 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 748449007449 KduI/IolB family; Region: KduI; pfam04962 748449007450 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 748449007451 intersubunit interface [polypeptide binding]; other site 748449007452 active site 748449007453 zinc binding site [ion binding]; other site 748449007454 Na+ binding site [ion binding]; other site 748449007455 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 748449007456 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 748449007457 substrate binding site [chemical binding]; other site 748449007458 ATP binding site [chemical binding]; other site 748449007459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748449007460 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 748449007461 TM-ABC transporter signature motif; other site 748449007462 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 748449007463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748449007464 Walker A/P-loop; other site 748449007465 ATP binding site [chemical binding]; other site 748449007466 Q-loop/lid; other site 748449007467 ABC transporter signature motif; other site 748449007468 Walker B; other site 748449007469 D-loop; other site 748449007470 H-loop/switch region; other site 748449007471 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 748449007472 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 748449007473 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 748449007474 putative ligand binding site [chemical binding]; other site 748449007475 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 748449007476 Melibiase; Region: Melibiase; pfam02065 748449007477 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 748449007478 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748449007479 Walker A/P-loop; other site 748449007480 ATP binding site [chemical binding]; other site 748449007481 Q-loop/lid; other site 748449007482 ABC transporter signature motif; other site 748449007483 Walker B; other site 748449007484 D-loop; other site 748449007485 H-loop/switch region; other site 748449007486 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 748449007487 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 748449007488 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748449007489 Walker A/P-loop; other site 748449007490 ATP binding site [chemical binding]; other site 748449007491 Q-loop/lid; other site 748449007492 ABC transporter signature motif; other site 748449007493 Walker B; other site 748449007494 D-loop; other site 748449007495 H-loop/switch region; other site 748449007496 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 748449007497 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 748449007498 dipeptide transporter; Provisional; Region: PRK10913 748449007499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449007500 dimer interface [polypeptide binding]; other site 748449007501 conserved gate region; other site 748449007502 putative PBP binding loops; other site 748449007503 ABC-ATPase subunit interface; other site 748449007504 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 748449007505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748449007506 dimer interface [polypeptide binding]; other site 748449007507 conserved gate region; other site 748449007508 putative PBP binding loops; other site 748449007509 ABC-ATPase subunit interface; other site 748449007510 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 748449007511 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 748449007512 alpha-galactosidase; Provisional; Region: PRK15076 748449007513 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 748449007514 NAD binding site [chemical binding]; other site 748449007515 sugar binding site [chemical binding]; other site 748449007516 divalent metal binding site [ion binding]; other site 748449007517 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 748449007518 dimer interface [polypeptide binding]; other site 748449007519 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748449007520 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 748449007521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748449007522 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748449007523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748449007524 Dehydratase family; Region: ILVD_EDD; cl00340 748449007525 Dehydratase family; Region: ILVD_EDD; pfam00920 748449007526 galactonate dehydratase; Provisional; Region: PRK14017 748449007527 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 748449007528 putative active site pocket [active] 748449007529 putative metal binding site [ion binding]; other site 748449007530 Domain of unknown function (DUF386); Region: DUF386; cl01047 748449007531 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 748449007532 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 748449007533 active site 748449007534 intersubunit interface [polypeptide binding]; other site 748449007535 catalytic residue [active] 748449007536 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 748449007537 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 748449007538 substrate binding site [chemical binding]; other site 748449007539 ATP binding site [chemical binding]; other site 748449007540 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 748449007541 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 748449007542 ligand binding site [chemical binding]; other site 748449007543 NAD binding site [chemical binding]; other site 748449007544 catalytic site [active] 748449007545 DctM-like transporters; Region: DctM; pfam06808 748449007546 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 748449007547 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 748449007548 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 748449007549 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 748449007550 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 748449007551 Transcriptional regulator [Transcription]; Region: IclR; COG1414 748449007552 Bacterial transcriptional regulator; Region: IclR; pfam01614 748449007553 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 748449007554 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 748449007555 NAD binding site [chemical binding]; other site 748449007556 sugar binding site [chemical binding]; other site 748449007557 divalent metal binding site [ion binding]; other site 748449007558 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 748449007559 dimer interface [polypeptide binding]; other site 748449007560 methionine cluster; other site 748449007561 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 748449007562 active site 748449007563 phosphorylation site [posttranslational modification] 748449007564 metal binding site [ion binding]; metal-binding site 748449007565 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748449007566 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 748449007567 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 748449007568 active site 748449007569 P-loop; other site 748449007570 phosphorylation site [posttranslational modification] 748449007571 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 748449007572 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 748449007573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449007574 Walker A motif; other site 748449007575 ATP binding site [chemical binding]; other site 748449007576 Walker B motif; other site 748449007577 arginine finger; other site 748449007578 Transcriptional antiterminator [Transcription]; Region: COG3933 748449007579 PRD domain; Region: PRD; pfam00874 748449007580 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 748449007581 active pocket/dimerization site; other site 748449007582 active site 748449007583 phosphorylation site [posttranslational modification] 748449007584 PRD domain; Region: PRD; pfam00874 748449007585 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 748449007586 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 748449007587 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 748449007588 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 748449007589 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 748449007590 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 748449007591 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 748449007592 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 748449007593 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 748449007594 dimerization domain swap beta strand [polypeptide binding]; other site 748449007595 regulatory protein interface [polypeptide binding]; other site 748449007596 active site 748449007597 regulatory phosphorylation site [posttranslational modification]; other site 748449007598 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 748449007599 regulatory protein interface [polypeptide binding]; other site 748449007600 active site 748449007601 regulatory phosphorylation site [posttranslational modification]; other site 748449007602 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 748449007603 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748449007604 putative active site [active] 748449007605 heme pocket [chemical binding]; other site 748449007606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748449007607 heme pocket [chemical binding]; other site 748449007608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748449007609 Walker A motif; other site 748449007610 ATP binding site [chemical binding]; other site 748449007611 Walker B motif; other site 748449007612 arginine finger; other site 748449007613 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 748449007614 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748449007615 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 748449007616 putative active site [active] 748449007617 putative NTP binding site [chemical binding]; other site 748449007618 putative nucleic acid binding site [nucleotide binding]; other site 748449007619 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748449007620 NAD synthetase; Provisional; Region: PRK13980 748449007621 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 748449007622 homodimer interface [polypeptide binding]; other site 748449007623 NAD binding pocket [chemical binding]; other site 748449007624 ATP binding pocket [chemical binding]; other site 748449007625 Mg binding site [ion binding]; other site 748449007626 active-site loop [active] 748449007627 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 748449007628 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 748449007629 active site 748449007630 P-loop; other site 748449007631 phosphorylation site [posttranslational modification] 748449007632 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 748449007633 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748449007634 active site 748449007635 phosphorylation site [posttranslational modification] 748449007636 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 748449007637 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 748449007638 putative substrate binding site [chemical binding]; other site 748449007639 putative ATP binding site [chemical binding]; other site 748449007640 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 748449007641 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 748449007642 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 748449007643 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 748449007644 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 748449007645 CotJB protein; Region: CotJB; pfam12652 748449007646 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 748449007647 dimanganese center [ion binding]; other site 748449007648 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 748449007649 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748449007650 active site 748449007651 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 748449007652 NlpC/P60 family; Region: NLPC_P60; cl17555 748449007653 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 748449007654 sporulation sigma factor SigG; Reviewed; Region: PRK08215 748449007655 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748449007656 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748449007657 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748449007658 DNA binding residues [nucleotide binding] 748449007659 Spore germination protein; Region: Spore_permease; cl17796 748449007660 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 748449007661 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 748449007662 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 748449007663 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 748449007664 Spore germination protein; Region: Spore_permease; cl17796 748449007665 ABC-2 type transporter; Region: ABC2_membrane; cl17235 748449007666 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748449007667 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748449007668 Walker A/P-loop; other site 748449007669 ATP binding site [chemical binding]; other site 748449007670 Q-loop/lid; other site 748449007671 ABC transporter signature motif; other site 748449007672 Walker B; other site 748449007673 D-loop; other site 748449007674 H-loop/switch region; other site 748449007675 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 748449007676 DNA-binding site [nucleotide binding]; DNA binding site 748449007677 RNA-binding motif; other site 748449007678 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 748449007679 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 748449007680 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 748449007681 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 748449007682 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 748449007683 protein binding site [polypeptide binding]; other site 748449007684 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 748449007685 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 748449007686 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 748449007687 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 748449007688 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 748449007689 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 748449007690 HflX GTPase family; Region: HflX; cd01878 748449007691 G1 box; other site 748449007692 GTP/Mg2+ binding site [chemical binding]; other site 748449007693 Switch I region; other site 748449007694 G2 box; other site 748449007695 G3 box; other site 748449007696 Switch II region; other site 748449007697 G4 box; other site 748449007698 G5 box; other site 748449007699 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 748449007700 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 748449007701 CoA binding domain; Region: CoA_binding; smart00881 748449007702 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 748449007703 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 748449007704 putative active site pocket [active] 748449007705 cleavage site 748449007706 thymidine kinase; Provisional; Region: PRK04296 748449007707 PAS domain; Region: PAS_9; pfam13426 748449007708 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 748449007709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 748449007710 metal binding site [ion binding]; metal-binding site 748449007711 active site 748449007712 I-site; other site 748449007713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748449007714 Zn2+ binding site [ion binding]; other site 748449007715 Mg2+ binding site [ion binding]; other site 748449007716 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 748449007717 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 748449007718 active site 748449007719 nucleophile elbow; other site 748449007720 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 748449007721 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 748449007722 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 748449007723 dimerization interface [polypeptide binding]; other site 748449007724 ATP binding site [chemical binding]; other site 748449007725 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 748449007726 dimerization interface [polypeptide binding]; other site 748449007727 ATP binding site [chemical binding]; other site 748449007728 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 748449007729 putative active site [active] 748449007730 catalytic triad [active] 748449007731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748449007732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748449007733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748449007734 dimerization interface [polypeptide binding]; other site 748449007735 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 748449007736 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748449007737 Predicted transcriptional regulators [Transcription]; Region: COG1733 748449007738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748449007739 dimerization interface [polypeptide binding]; other site 748449007740 putative DNA binding site [nucleotide binding]; other site 748449007741 putative Zn2+ binding site [ion binding]; other site 748449007742 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 748449007743 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 748449007744 purine monophosphate binding site [chemical binding]; other site 748449007745 dimer interface [polypeptide binding]; other site 748449007746 putative catalytic residues [active] 748449007747 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 748449007748 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 748449007749 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 748449007750 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 748449007751 active site 748449007752 substrate binding site [chemical binding]; other site 748449007753 cosubstrate binding site; other site 748449007754 catalytic site [active] 748449007755 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 748449007756 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 748449007757 dimerization interface [polypeptide binding]; other site 748449007758 putative ATP binding site [chemical binding]; other site 748449007759 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 748449007760 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 748449007761 active site 748449007762 tetramer interface [polypeptide binding]; other site 748449007763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748449007764 active site 748449007765 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 748449007766 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 748449007767 ATP binding site [chemical binding]; other site 748449007768 active site 748449007769 substrate binding site [chemical binding]; other site 748449007770 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 748449007771 Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595 748449007772 tetramer interface [polypeptide binding]; other site 748449007773 active site 748449007774 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 748449007775 AIR carboxylase; Region: AIRC; pfam00731 748449007776 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 748449007777 ATP-grasp domain; Region: ATP-grasp; pfam02222 748449007778 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 748449007779 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 748449007780 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 748449007781 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 748449007782 ykkC-yxkD leader; Halha_2591 748449007783 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 748449007784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449007785 FeS/SAM binding site; other site 748449007786 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 748449007787 Pyruvate formate lyase 1; Region: PFL1; cd01678 748449007788 coenzyme A binding site [chemical binding]; other site 748449007789 active site 748449007790 catalytic residues [active] 748449007791 glycine loop; other site 748449007792 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 748449007793 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 748449007794 GDP-binding site [chemical binding]; other site 748449007795 ACT binding site; other site 748449007796 IMP binding site; other site 748449007797 adenylosuccinate lyase; Provisional; Region: PRK07380 748449007798 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 748449007799 tetramer interface [polypeptide binding]; other site 748449007800 active site 748449007801 Accessory gene regulator B; Region: AgrB; pfam04647 748449007802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748449007803 ATP binding site [chemical binding]; other site 748449007804 Mg2+ binding site [ion binding]; other site 748449007805 G-X-G motif; other site 748449007806 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748449007807 replicative DNA helicase; Region: DnaB; TIGR00665 748449007808 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 748449007809 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 748449007810 Walker A motif; other site 748449007811 ATP binding site [chemical binding]; other site 748449007812 Walker B motif; other site 748449007813 DNA binding loops [nucleotide binding] 748449007814 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 748449007815 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 748449007816 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 748449007817 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 748449007818 MazG-like family; Region: MazG-like; pfam12643 748449007819 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 748449007820 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 748449007821 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 748449007822 dimer interface [polypeptide binding]; other site 748449007823 ssDNA binding site [nucleotide binding]; other site 748449007824 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748449007825 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 748449007826 GTP-binding protein YchF; Reviewed; Region: PRK09601 748449007827 YchF GTPase; Region: YchF; cd01900 748449007828 G1 box; other site 748449007829 GTP/Mg2+ binding site [chemical binding]; other site 748449007830 Switch I region; other site 748449007831 G2 box; other site 748449007832 Switch II region; other site 748449007833 G3 box; other site 748449007834 G4 box; other site 748449007835 G5 box; other site 748449007836 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 748449007837 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 748449007838 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 748449007839 Mechanosensitive ion channel; Region: MS_channel; pfam00924 748449007840 alanine racemase; Reviewed; Region: alr; PRK00053 748449007841 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 748449007842 active site 748449007843 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748449007844 dimer interface [polypeptide binding]; other site 748449007845 substrate binding site [chemical binding]; other site 748449007846 catalytic residues [active] 748449007847 Uncharacterized membrane protein [Function unknown]; Region: COG3949 748449007848 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 748449007849 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 748449007850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748449007851 Coenzyme A binding pocket [chemical binding]; other site 748449007852 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 748449007853 DNA topoisomerase I; Validated; Region: PRK05582 748449007854 Protein of unknown function (DUF554); Region: DUF554; pfam04474 748449007855 GEMM cis-regulatory element; Halha_2620 748449007856 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 748449007857 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 748449007858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748449007859 catalytic residue [active] 748449007860 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 748449007861 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 748449007862 G1 box; other site 748449007863 GTP/Mg2+ binding site [chemical binding]; other site 748449007864 Switch I region; other site 748449007865 G2 box; other site 748449007866 Switch II region; other site 748449007867 G3 box; other site 748449007868 G4 box; other site 748449007869 G5 box; other site 748449007870 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 748449007871 biotin synthase; Provisional; Region: PRK07094 748449007872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449007873 FeS/SAM binding site; other site 748449007874 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 748449007875 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 748449007876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 748449007877 FeS/SAM binding site; other site 748449007878 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 748449007879 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 748449007880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748449007881 S-adenosylmethionine binding site [chemical binding]; other site 748449007882 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 748449007883 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 748449007884 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 748449007885 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 748449007886 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 748449007887 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 748449007888 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 748449007889 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 748449007890 trmE is a tRNA modification GTPase; Region: trmE; cd04164 748449007891 G1 box; other site 748449007892 GTP/Mg2+ binding site [chemical binding]; other site 748449007893 Switch I region; other site 748449007894 G2 box; other site 748449007895 Switch II region; other site 748449007896 G3 box; other site 748449007897 G4 box; other site 748449007898 G5 box; other site 748449007899 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 748449007900 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 748449007901 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 748449007902 G-X-X-G motif; other site 748449007903 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 748449007904 RxxxH motif; other site 748449007905 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 748449007906 Haemolytic domain; Region: Haemolytic; pfam01809 748449007907 ribonuclease P; Reviewed; Region: rnpA; PRK00499