-- dump date 20140619_111231 -- class Genbank::misc_feature -- table misc_feature_note -- id note 768066000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768066000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 768066000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066000004 Walker A motif; other site 768066000005 ATP binding site [chemical binding]; other site 768066000006 Walker B motif; other site 768066000007 arginine finger; other site 768066000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 768066000009 DnaA box-binding interface [nucleotide binding]; other site 768066000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 768066000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 768066000012 putative DNA binding surface [nucleotide binding]; other site 768066000013 dimer interface [polypeptide binding]; other site 768066000014 beta-clamp/clamp loader binding surface; other site 768066000015 beta-clamp/translesion DNA polymerase binding surface; other site 768066000016 recombination protein F; Reviewed; Region: recF; PRK00064 768066000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066000018 Walker A/P-loop; other site 768066000019 ATP binding site [chemical binding]; other site 768066000020 Q-loop/lid; other site 768066000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066000022 ABC transporter signature motif; other site 768066000023 Walker B; other site 768066000024 D-loop; other site 768066000025 H-loop/switch region; other site 768066000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 768066000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066000028 ATP binding site [chemical binding]; other site 768066000029 Mg2+ binding site [ion binding]; other site 768066000030 G-X-G motif; other site 768066000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768066000032 anchoring element; other site 768066000033 dimer interface [polypeptide binding]; other site 768066000034 ATP binding site [chemical binding]; other site 768066000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768066000036 active site 768066000037 putative metal-binding site [ion binding]; other site 768066000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768066000039 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 768066000040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066000041 active site 768066000042 motif I; other site 768066000043 motif II; other site 768066000044 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768066000045 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 768066000046 putative NAD(P) binding site [chemical binding]; other site 768066000047 active site 768066000048 putative substrate binding site [chemical binding]; other site 768066000049 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 768066000050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768066000051 putative ADP-binding pocket [chemical binding]; other site 768066000052 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 768066000053 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 768066000054 putative ADP-binding pocket [chemical binding]; other site 768066000055 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 768066000056 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 768066000057 dimer interface [polypeptide binding]; other site 768066000058 motif 1; other site 768066000059 active site 768066000060 motif 2; other site 768066000061 motif 3; other site 768066000062 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 768066000063 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 768066000064 NADP binding site [chemical binding]; other site 768066000065 homopentamer interface [polypeptide binding]; other site 768066000066 substrate binding site [chemical binding]; other site 768066000067 active site 768066000068 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768066000069 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768066000070 putative active site [active] 768066000071 Sulfatase; Region: Sulfatase; cl17466 768066000072 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 768066000073 putative metal binding site; other site 768066000074 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768066000075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768066000076 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768066000077 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768066000078 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768066000079 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768066000080 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768066000081 putative active site [active] 768066000082 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 768066000083 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 768066000084 putative ribose interaction site [chemical binding]; other site 768066000085 putative ADP binding site [chemical binding]; other site 768066000086 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 768066000087 active site 768066000088 HIGH motif; other site 768066000089 nucleotide binding site [chemical binding]; other site 768066000090 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 768066000091 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 768066000092 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768066000093 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 768066000094 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768066000095 active site 768066000096 dimer interface [polypeptide binding]; other site 768066000097 threonine dehydratase; Reviewed; Region: PRK09224 768066000098 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768066000099 tetramer interface [polypeptide binding]; other site 768066000100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066000101 catalytic residue [active] 768066000102 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 768066000103 putative Ile/Val binding site [chemical binding]; other site 768066000104 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 768066000105 putative Ile/Val binding site [chemical binding]; other site 768066000106 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 768066000107 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 768066000108 Cell division protein ZapA; Region: ZapA; pfam05164 768066000109 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 768066000110 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 768066000111 proline aminopeptidase P II; Provisional; Region: PRK10879 768066000112 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 768066000113 active site 768066000114 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 768066000115 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 768066000116 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768066000117 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 768066000118 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 768066000119 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 768066000120 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 768066000121 protein binding site [polypeptide binding]; other site 768066000122 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 768066000123 Catalytic dyad [active] 768066000124 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 768066000125 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 768066000126 Peptidase family M23; Region: Peptidase_M23; pfam01551 768066000127 phosphoglyceromutase; Provisional; Region: PRK05434 768066000128 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 768066000129 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768066000130 active site residue [active] 768066000131 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 768066000132 SecA binding site; other site 768066000133 Preprotein binding site; other site 768066000134 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 768066000135 RNA methyltransferase, RsmE family; Region: TIGR00046 768066000136 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768066000137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066000138 DNA-binding site [nucleotide binding]; DNA binding site 768066000139 FCD domain; Region: FCD; pfam07729 768066000140 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066000141 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066000142 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 768066000143 DctM-like transporters; Region: DctM; pfam06808 768066000144 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066000145 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 768066000146 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 768066000147 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768066000148 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 768066000149 putative active site pocket [active] 768066000150 putative metal binding site [ion binding]; other site 768066000151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 768066000152 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768066000153 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 768066000154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066000155 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 768066000156 putative dimerization interface [polypeptide binding]; other site 768066000157 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 768066000158 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 768066000159 putative active site [active] 768066000160 metal binding site [ion binding]; metal-binding site 768066000161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768066000162 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 768066000163 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 768066000164 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 768066000165 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768066000166 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768066000167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066000168 DNA-binding site [nucleotide binding]; DNA binding site 768066000169 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 768066000170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 768066000171 DNA-binding site [nucleotide binding]; DNA binding site 768066000172 FCD domain; Region: FCD; pfam07729 768066000173 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 768066000174 galactarate dehydratase; Region: galactar-dH20; TIGR03248 768066000175 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 768066000176 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768066000177 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 768066000178 metal binding site [ion binding]; metal-binding site 768066000179 substrate binding pocket [chemical binding]; other site 768066000180 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066000181 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066000182 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066000183 DctM-like transporters; Region: DctM; pfam06808 768066000184 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066000185 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768066000186 FAD binding domain; Region: FAD_binding_4; pfam01565 768066000187 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 768066000188 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768066000189 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768066000190 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 768066000191 dimer interface [polypeptide binding]; other site 768066000192 NADP binding site [chemical binding]; other site 768066000193 catalytic residues [active] 768066000194 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 768066000195 glutathione synthetase; Provisional; Region: PRK05246 768066000196 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 768066000197 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 768066000198 hypothetical protein; Validated; Region: PRK00228 768066000199 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 768066000200 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768066000201 aspartate carbamoyltransferase; Provisional; Region: PRK08192 768066000202 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768066000203 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768066000204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066000205 DNA-binding site [nucleotide binding]; DNA binding site 768066000206 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066000207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066000208 homodimer interface [polypeptide binding]; other site 768066000209 catalytic residue [active] 768066000210 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 768066000211 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 768066000212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066000213 putative substrate translocation pore; other site 768066000214 maleylacetoacetate isomerase; Region: maiA; TIGR01262 768066000215 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 768066000216 C-terminal domain interface [polypeptide binding]; other site 768066000217 GSH binding site (G-site) [chemical binding]; other site 768066000218 putative dimer interface [polypeptide binding]; other site 768066000219 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 768066000220 dimer interface [polypeptide binding]; other site 768066000221 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 768066000222 N-terminal domain interface [polypeptide binding]; other site 768066000223 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768066000224 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768066000225 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 768066000226 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768066000227 MarR family; Region: MarR_2; pfam12802 768066000228 transcriptional repressor IclR; Provisional; Region: PRK11569 768066000229 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768066000230 Bacterial transcriptional regulator; Region: IclR; pfam01614 768066000231 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768066000232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066000233 active site 768066000234 phosphorylation site [posttranslational modification] 768066000235 intermolecular recognition site; other site 768066000236 dimerization interface [polypeptide binding]; other site 768066000237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066000238 Walker A motif; other site 768066000239 ATP binding site [chemical binding]; other site 768066000240 Walker B motif; other site 768066000241 arginine finger; other site 768066000242 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768066000243 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 768066000244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066000245 dimer interface [polypeptide binding]; other site 768066000246 phosphorylation site [posttranslational modification] 768066000247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066000248 ATP binding site [chemical binding]; other site 768066000249 Mg2+ binding site [ion binding]; other site 768066000250 G-X-G motif; other site 768066000251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066000252 xanthine permease; Region: pbuX; TIGR03173 768066000253 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 768066000254 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 768066000255 active site 768066000256 putative substrate binding pocket [chemical binding]; other site 768066000257 Spore Coat Protein U domain; Region: SCPU; pfam05229 768066000258 Spore Coat Protein U domain; Region: SCPU; pfam05229 768066000259 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 768066000260 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 768066000261 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 768066000262 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 768066000263 PapC C-terminal domain; Region: PapC_C; pfam13953 768066000264 Spore Coat Protein U domain; Region: SCPU; pfam05229 768066000265 Spore Coat Protein U domain; Region: SCPU; pfam05229 768066000266 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 768066000267 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 768066000268 ligand binding site [chemical binding]; other site 768066000269 NAD binding site [chemical binding]; other site 768066000270 tetramer interface [polypeptide binding]; other site 768066000271 catalytic site [active] 768066000272 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 768066000273 L-serine binding site [chemical binding]; other site 768066000274 ACT domain interface; other site 768066000275 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 768066000276 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768066000277 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768066000278 substrate binding pocket [chemical binding]; other site 768066000279 chain length determination region; other site 768066000280 substrate-Mg2+ binding site; other site 768066000281 catalytic residues [active] 768066000282 aspartate-rich region 1; other site 768066000283 active site lid residues [active] 768066000284 aspartate-rich region 2; other site 768066000285 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768066000286 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768066000287 TPP-binding site; other site 768066000288 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768066000289 PYR/PP interface [polypeptide binding]; other site 768066000290 dimer interface [polypeptide binding]; other site 768066000291 TPP binding site [chemical binding]; other site 768066000292 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768066000293 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 768066000294 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 768066000295 putative metal binding site [ion binding]; other site 768066000296 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768066000297 HSP70 interaction site [polypeptide binding]; other site 768066000298 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 768066000299 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 768066000300 dimerization interface [polypeptide binding]; other site 768066000301 active site 768066000302 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 768066000303 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 768066000304 substrate binding site [chemical binding]; other site 768066000305 active site 768066000306 spermidine synthase; Provisional; Region: PRK00811 768066000307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066000308 S-adenosylmethionine binding site [chemical binding]; other site 768066000309 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 768066000310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066000311 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768066000312 putative dimerization interface [polypeptide binding]; other site 768066000313 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 768066000314 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 768066000315 FAD binding pocket [chemical binding]; other site 768066000316 FAD binding motif [chemical binding]; other site 768066000317 phosphate binding motif [ion binding]; other site 768066000318 beta-alpha-beta structure motif; other site 768066000319 NAD binding pocket [chemical binding]; other site 768066000320 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066000321 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066000322 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 768066000323 DctM-like transporters; Region: DctM; pfam06808 768066000324 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066000325 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 768066000326 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 768066000327 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 768066000328 putative active site [active] 768066000329 putative catalytic site [active] 768066000330 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 768066000331 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768066000332 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 768066000333 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 768066000334 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768066000335 Membrane fusogenic activity; Region: BMFP; pfam04380 768066000336 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 768066000337 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768066000338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066000339 Walker A motif; other site 768066000340 ATP binding site [chemical binding]; other site 768066000341 Walker B motif; other site 768066000342 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 768066000343 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 768066000344 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 768066000345 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 768066000346 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 768066000347 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 768066000348 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 768066000349 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 768066000350 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768066000351 active site 768066000352 catalytic site [active] 768066000353 metal binding site [ion binding]; metal-binding site 768066000354 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 768066000355 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 768066000356 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768066000357 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 768066000358 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768066000359 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768066000360 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 768066000361 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768066000362 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 768066000363 TM-ABC transporter signature motif; other site 768066000364 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768066000365 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768066000366 TM-ABC transporter signature motif; other site 768066000367 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768066000368 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768066000369 Walker A/P-loop; other site 768066000370 ATP binding site [chemical binding]; other site 768066000371 Q-loop/lid; other site 768066000372 ABC transporter signature motif; other site 768066000373 Walker B; other site 768066000374 D-loop; other site 768066000375 H-loop/switch region; other site 768066000376 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 768066000377 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768066000378 Walker A/P-loop; other site 768066000379 ATP binding site [chemical binding]; other site 768066000380 Q-loop/lid; other site 768066000381 ABC transporter signature motif; other site 768066000382 Walker B; other site 768066000383 D-loop; other site 768066000384 H-loop/switch region; other site 768066000385 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 768066000386 Na2 binding site [ion binding]; other site 768066000387 putative substrate binding site 1 [chemical binding]; other site 768066000388 Na binding site 1 [ion binding]; other site 768066000389 putative substrate binding site 2 [chemical binding]; other site 768066000390 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 768066000391 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 768066000392 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 768066000393 G1 box; other site 768066000394 putative GEF interaction site [polypeptide binding]; other site 768066000395 GTP/Mg2+ binding site [chemical binding]; other site 768066000396 Switch I region; other site 768066000397 G2 box; other site 768066000398 G3 box; other site 768066000399 Switch II region; other site 768066000400 G4 box; other site 768066000401 G5 box; other site 768066000402 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 768066000403 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 768066000404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066000405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066000406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768066000407 dimerization interface [polypeptide binding]; other site 768066000408 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 768066000409 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768066000410 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768066000411 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 768066000412 active site 768066000413 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 768066000414 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768066000415 glutamine synthetase; Provisional; Region: glnA; PRK09469 768066000416 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 768066000417 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768066000418 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 768066000419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066000420 dimer interface [polypeptide binding]; other site 768066000421 phosphorylation site [posttranslational modification] 768066000422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066000423 ATP binding site [chemical binding]; other site 768066000424 Mg2+ binding site [ion binding]; other site 768066000425 G-X-G motif; other site 768066000426 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 768066000427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066000428 active site 768066000429 phosphorylation site [posttranslational modification] 768066000430 intermolecular recognition site; other site 768066000431 dimerization interface [polypeptide binding]; other site 768066000432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066000433 Walker A motif; other site 768066000434 ATP binding site [chemical binding]; other site 768066000435 Walker B motif; other site 768066000436 arginine finger; other site 768066000437 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768066000438 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 768066000439 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768066000440 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768066000441 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768066000442 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 768066000443 active site 768066000444 POT family; Region: PTR2; cl17359 768066000445 POT family; Region: PTR2; cl17359 768066000446 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 768066000447 active site 768066000448 catalytic residues [active] 768066000449 metal binding site [ion binding]; metal-binding site 768066000450 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 768066000451 CoA-transferase family III; Region: CoA_transf_3; pfam02515 768066000452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768066000453 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768066000454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 768066000455 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 768066000456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768066000457 Zn2+ binding site [ion binding]; other site 768066000458 Mg2+ binding site [ion binding]; other site 768066000459 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768066000460 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 768066000461 CAS motifs; other site 768066000462 active site 768066000463 Nuclease-related domain; Region: NERD; pfam08378 768066000464 NAD-dependent deacetylase; Provisional; Region: PRK00481 768066000465 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 768066000466 NAD+ binding site [chemical binding]; other site 768066000467 substrate binding site [chemical binding]; other site 768066000468 Zn binding site [ion binding]; other site 768066000469 translation initiation factor Sui1; Validated; Region: PRK06824 768066000470 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 768066000471 putative rRNA binding site [nucleotide binding]; other site 768066000472 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 768066000473 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768066000474 phosphate binding site [ion binding]; other site 768066000475 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768066000476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066000477 DNA-binding site [nucleotide binding]; DNA binding site 768066000478 FCD domain; Region: FCD; pfam07729 768066000479 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 768066000480 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 768066000481 metal binding site [ion binding]; metal-binding site 768066000482 substrate binding pocket [chemical binding]; other site 768066000483 putative oxidoreductase; Provisional; Region: PRK10083 768066000484 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768066000485 putative NAD(P) binding site [chemical binding]; other site 768066000486 catalytic Zn binding site [ion binding]; other site 768066000487 structural Zn binding site [ion binding]; other site 768066000488 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066000489 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066000490 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066000491 DctM-like transporters; Region: DctM; pfam06808 768066000492 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066000493 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 768066000494 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768066000495 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768066000496 mannonate dehydratase; Provisional; Region: PRK03906 768066000497 mannonate dehydratase; Region: uxuA; TIGR00695 768066000498 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 768066000499 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066000500 N-terminal plug; other site 768066000501 ligand-binding site [chemical binding]; other site 768066000502 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 768066000503 FAD binding pocket [chemical binding]; other site 768066000504 FAD binding motif [chemical binding]; other site 768066000505 phosphate binding motif [ion binding]; other site 768066000506 NAD binding pocket [chemical binding]; other site 768066000507 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 768066000508 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768066000509 MarR family; Region: MarR_2; cl17246 768066000510 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768066000511 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768066000512 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 768066000513 classical (c) SDRs; Region: SDR_c; cd05233 768066000514 NAD(P) binding site [chemical binding]; other site 768066000515 active site 768066000516 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768066000517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768066000518 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768066000519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066000520 dimer interface [polypeptide binding]; other site 768066000521 conserved gate region; other site 768066000522 putative PBP binding loops; other site 768066000523 ABC-ATPase subunit interface; other site 768066000524 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768066000525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066000526 dimer interface [polypeptide binding]; other site 768066000527 conserved gate region; other site 768066000528 putative PBP binding loops; other site 768066000529 ABC-ATPase subunit interface; other site 768066000530 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 768066000531 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 768066000532 inhibitor binding site; inhibition site 768066000533 active site 768066000534 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768066000535 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768066000536 Walker A/P-loop; other site 768066000537 ATP binding site [chemical binding]; other site 768066000538 Q-loop/lid; other site 768066000539 ABC transporter signature motif; other site 768066000540 Walker B; other site 768066000541 D-loop; other site 768066000542 H-loop/switch region; other site 768066000543 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768066000544 trimer interface; other site 768066000545 sugar binding site [chemical binding]; other site 768066000546 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 768066000547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066000548 putative substrate translocation pore; other site 768066000549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066000550 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 768066000551 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768066000552 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 768066000553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066000554 motif II; other site 768066000555 DctM-like transporters; Region: DctM; pfam06808 768066000556 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066000557 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 768066000558 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066000559 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066000560 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 768066000561 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 768066000562 dimerization interface [polypeptide binding]; other site 768066000563 ligand binding site [chemical binding]; other site 768066000564 NADP binding site [chemical binding]; other site 768066000565 catalytic site [active] 768066000566 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768066000567 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768066000568 substrate binding site [chemical binding]; other site 768066000569 ATP binding site [chemical binding]; other site 768066000570 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768066000571 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768066000572 DNA binding site [nucleotide binding] 768066000573 domain linker motif; other site 768066000574 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 768066000575 putative dimerization interface [polypeptide binding]; other site 768066000576 putative ligand binding site [chemical binding]; other site 768066000577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768066000578 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768066000579 DNA binding residues [nucleotide binding] 768066000580 dimerization interface [polypeptide binding]; other site 768066000581 hypothetical protein; Provisional; Region: PRK07036 768066000582 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066000583 inhibitor-cofactor binding pocket; inhibition site 768066000584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066000585 catalytic residue [active] 768066000586 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 768066000587 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 768066000588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066000589 motif II; other site 768066000590 Helix-turn-helix domain; Region: HTH_31; pfam13560 768066000591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066000592 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768066000593 putative substrate translocation pore; other site 768066000594 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768066000595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066000596 Coenzyme A binding pocket [chemical binding]; other site 768066000597 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768066000598 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 768066000599 intersubunit interface [polypeptide binding]; other site 768066000600 active site 768066000601 zinc binding site [ion binding]; other site 768066000602 Na+ binding site [ion binding]; other site 768066000603 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 768066000604 Phosphoglycerate kinase; Region: PGK; pfam00162 768066000605 substrate binding site [chemical binding]; other site 768066000606 hinge regions; other site 768066000607 ADP binding site [chemical binding]; other site 768066000608 catalytic site [active] 768066000609 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 768066000610 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768066000611 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768066000612 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 768066000613 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 768066000614 putative active site; other site 768066000615 catalytic residue [active] 768066000616 transketolase; Reviewed; Region: PRK12753 768066000617 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768066000618 TPP-binding site [chemical binding]; other site 768066000619 dimer interface [polypeptide binding]; other site 768066000620 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768066000621 PYR/PP interface [polypeptide binding]; other site 768066000622 dimer interface [polypeptide binding]; other site 768066000623 TPP binding site [chemical binding]; other site 768066000624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768066000625 transaldolase-like protein; Provisional; Region: PTZ00411 768066000626 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768066000627 active site 768066000628 dimer interface [polypeptide binding]; other site 768066000629 catalytic residue [active] 768066000630 DAK2 domain; Region: Dak2; pfam02734 768066000631 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 768066000632 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 768066000633 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 768066000634 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 768066000635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 768066000636 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 768066000637 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768066000638 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 768066000639 putative NAD(P) binding site [chemical binding]; other site 768066000640 catalytic Zn binding site [ion binding]; other site 768066000641 structural Zn binding site [ion binding]; other site 768066000642 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 768066000643 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768066000644 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768066000645 Walker A/P-loop; other site 768066000646 ATP binding site [chemical binding]; other site 768066000647 Q-loop/lid; other site 768066000648 ABC transporter signature motif; other site 768066000649 Walker B; other site 768066000650 D-loop; other site 768066000651 H-loop/switch region; other site 768066000652 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768066000653 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768066000654 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768066000655 TM-ABC transporter signature motif; other site 768066000656 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 768066000657 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768066000658 ligand binding site [chemical binding]; other site 768066000659 dimerization interface [polypeptide binding]; other site 768066000660 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 768066000661 active site 768066000662 homopentamer interface [polypeptide binding]; other site 768066000663 transketolase; Reviewed; Region: PRK12753 768066000664 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768066000665 TPP-binding site [chemical binding]; other site 768066000666 dimer interface [polypeptide binding]; other site 768066000667 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768066000668 PYR/PP interface [polypeptide binding]; other site 768066000669 dimer interface [polypeptide binding]; other site 768066000670 TPP binding site [chemical binding]; other site 768066000671 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768066000672 S-adenosylmethionine synthetase; Validated; Region: PRK05250 768066000673 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 768066000674 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 768066000675 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 768066000676 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 768066000677 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 768066000678 nucleotide binding pocket [chemical binding]; other site 768066000679 K-X-D-G motif; other site 768066000680 catalytic site [active] 768066000681 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768066000682 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 768066000683 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 768066000684 homotetramer interface [polypeptide binding]; other site 768066000685 ligand binding site [chemical binding]; other site 768066000686 catalytic site [active] 768066000687 NAD binding site [chemical binding]; other site 768066000688 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 768066000689 putative active site [active] 768066000690 putative metal binding site [ion binding]; other site 768066000691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066000692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066000693 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768066000694 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768066000695 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 768066000696 N-terminal domain interface [polypeptide binding]; other site 768066000697 dimer interface [polypeptide binding]; other site 768066000698 substrate binding pocket (H-site) [chemical binding]; other site 768066000699 Membrane transport protein; Region: Mem_trans; cl09117 768066000700 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 768066000701 FAD binding site [chemical binding]; other site 768066000702 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 768066000703 DctM-like transporters; Region: DctM; pfam06808 768066000704 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 768066000705 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 768066000706 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768066000707 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768066000708 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768066000709 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 768066000710 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768066000711 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 768066000712 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 768066000713 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 768066000714 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 768066000715 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 768066000716 active site 768066000717 Zn binding site [ion binding]; other site 768066000718 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 768066000719 Na2 binding site [ion binding]; other site 768066000720 putative substrate binding site 1 [chemical binding]; other site 768066000721 Na binding site 1 [ion binding]; other site 768066000722 putative substrate binding site 2 [chemical binding]; other site 768066000723 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768066000724 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 768066000725 trimer interface [polypeptide binding]; other site 768066000726 putative metal binding site [ion binding]; other site 768066000727 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 768066000728 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768066000729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066000730 active site 768066000731 phosphorylation site [posttranslational modification] 768066000732 intermolecular recognition site; other site 768066000733 dimerization interface [polypeptide binding]; other site 768066000734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066000735 Walker A motif; other site 768066000736 ATP binding site [chemical binding]; other site 768066000737 Walker B motif; other site 768066000738 arginine finger; other site 768066000739 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768066000740 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 768066000741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066000742 dimer interface [polypeptide binding]; other site 768066000743 phosphorylation site [posttranslational modification] 768066000744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066000745 ATP binding site [chemical binding]; other site 768066000746 Mg2+ binding site [ion binding]; other site 768066000747 G-X-G motif; other site 768066000748 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 768066000749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066000750 DNA-binding site [nucleotide binding]; DNA binding site 768066000751 FCD domain; Region: FCD; pfam07729 768066000752 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 768066000753 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 768066000754 active site 768066000755 substrate binding site [chemical binding]; other site 768066000756 FMN binding site [chemical binding]; other site 768066000757 putative catalytic residues [active] 768066000758 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 768066000759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768066000760 putative DNA binding site [nucleotide binding]; other site 768066000761 dimerization interface [polypeptide binding]; other site 768066000762 putative Zn2+ binding site [ion binding]; other site 768066000763 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 768066000764 Type III pantothenate kinase; Region: Pan_kinase; cl17198 768066000765 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 768066000766 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 768066000767 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 768066000768 putative homodimer interface [polypeptide binding]; other site 768066000769 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 768066000770 heterodimer interface [polypeptide binding]; other site 768066000771 homodimer interface [polypeptide binding]; other site 768066000772 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 768066000773 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 768066000774 23S rRNA interface [nucleotide binding]; other site 768066000775 L7/L12 interface [polypeptide binding]; other site 768066000776 putative thiostrepton binding site; other site 768066000777 L25 interface [polypeptide binding]; other site 768066000778 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 768066000779 mRNA/rRNA interface [nucleotide binding]; other site 768066000780 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 768066000781 23S rRNA interface [nucleotide binding]; other site 768066000782 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 768066000783 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 768066000784 core dimer interface [polypeptide binding]; other site 768066000785 peripheral dimer interface [polypeptide binding]; other site 768066000786 L10 interface [polypeptide binding]; other site 768066000787 L11 interface [polypeptide binding]; other site 768066000788 putative EF-Tu interaction site [polypeptide binding]; other site 768066000789 putative EF-G interaction site [polypeptide binding]; other site 768066000790 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 768066000791 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 768066000792 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 768066000793 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768066000794 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 768066000795 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768066000796 RPB3 interaction site [polypeptide binding]; other site 768066000797 RPB1 interaction site [polypeptide binding]; other site 768066000798 RPB11 interaction site [polypeptide binding]; other site 768066000799 RPB10 interaction site [polypeptide binding]; other site 768066000800 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 768066000801 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 768066000802 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 768066000803 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 768066000804 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 768066000805 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 768066000806 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768066000807 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 768066000808 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768066000809 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 768066000810 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 768066000811 DNA binding site [nucleotide binding] 768066000812 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 768066000813 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 768066000814 S17 interaction site [polypeptide binding]; other site 768066000815 S8 interaction site; other site 768066000816 16S rRNA interaction site [nucleotide binding]; other site 768066000817 streptomycin interaction site [chemical binding]; other site 768066000818 23S rRNA interaction site [nucleotide binding]; other site 768066000819 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 768066000820 30S ribosomal protein S7; Validated; Region: PRK05302 768066000821 elongation factor G; Reviewed; Region: PRK00007 768066000822 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768066000823 G1 box; other site 768066000824 putative GEF interaction site [polypeptide binding]; other site 768066000825 GTP/Mg2+ binding site [chemical binding]; other site 768066000826 Switch I region; other site 768066000827 G2 box; other site 768066000828 G3 box; other site 768066000829 Switch II region; other site 768066000830 G4 box; other site 768066000831 G5 box; other site 768066000832 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768066000833 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768066000834 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768066000835 elongation factor Tu; Reviewed; Region: PRK00049 768066000836 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768066000837 G1 box; other site 768066000838 GEF interaction site [polypeptide binding]; other site 768066000839 GTP/Mg2+ binding site [chemical binding]; other site 768066000840 Switch I region; other site 768066000841 G2 box; other site 768066000842 G3 box; other site 768066000843 Switch II region; other site 768066000844 G4 box; other site 768066000845 G5 box; other site 768066000846 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768066000847 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768066000848 Antibiotic Binding Site [chemical binding]; other site 768066000849 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 768066000850 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 768066000851 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 768066000852 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 768066000853 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 768066000854 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 768066000855 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 768066000856 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 768066000857 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 768066000858 putative translocon binding site; other site 768066000859 protein-rRNA interface [nucleotide binding]; other site 768066000860 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 768066000861 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 768066000862 G-X-X-G motif; other site 768066000863 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 768066000864 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 768066000865 23S rRNA interface [nucleotide binding]; other site 768066000866 5S rRNA interface [nucleotide binding]; other site 768066000867 putative antibiotic binding site [chemical binding]; other site 768066000868 L25 interface [polypeptide binding]; other site 768066000869 L27 interface [polypeptide binding]; other site 768066000870 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 768066000871 23S rRNA interface [nucleotide binding]; other site 768066000872 putative translocon interaction site; other site 768066000873 signal recognition particle (SRP54) interaction site; other site 768066000874 L23 interface [polypeptide binding]; other site 768066000875 trigger factor interaction site; other site 768066000876 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 768066000877 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 768066000878 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 768066000879 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 768066000880 RNA binding site [nucleotide binding]; other site 768066000881 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 768066000882 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 768066000883 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 768066000884 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 768066000885 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 768066000886 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 768066000887 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768066000888 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768066000889 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 768066000890 5S rRNA interface [nucleotide binding]; other site 768066000891 23S rRNA interface [nucleotide binding]; other site 768066000892 L5 interface [polypeptide binding]; other site 768066000893 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 768066000894 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 768066000895 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 768066000896 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 768066000897 23S rRNA binding site [nucleotide binding]; other site 768066000898 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 768066000899 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 768066000900 SecY translocase; Region: SecY; pfam00344 768066000901 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 768066000902 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 768066000903 30S ribosomal protein S13; Region: bact_S13; TIGR03631 768066000904 30S ribosomal protein S11; Validated; Region: PRK05309 768066000905 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 768066000906 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 768066000907 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768066000908 RNA binding surface [nucleotide binding]; other site 768066000909 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 768066000910 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 768066000911 alphaNTD homodimer interface [polypeptide binding]; other site 768066000912 alphaNTD - beta interaction site [polypeptide binding]; other site 768066000913 alphaNTD - beta' interaction site [polypeptide binding]; other site 768066000914 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 768066000915 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 768066000916 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 768066000917 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768066000918 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768066000919 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 768066000920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066000921 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768066000922 putative substrate translocation pore; other site 768066000923 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768066000924 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768066000925 dimer interface [polypeptide binding]; other site 768066000926 ssDNA binding site [nucleotide binding]; other site 768066000927 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768066000928 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 768066000929 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 768066000930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066000931 active site 768066000932 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768066000933 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768066000934 putative acyl-acceptor binding pocket; other site 768066000935 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 768066000936 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768066000937 dimer interface [polypeptide binding]; other site 768066000938 active site 768066000939 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 768066000940 active site 1 [active] 768066000941 dimer interface [polypeptide binding]; other site 768066000942 active site 2 [active] 768066000943 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 768066000944 DNA photolyase; Region: DNA_photolyase; pfam00875 768066000945 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768066000946 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 768066000947 DNA binding residues [nucleotide binding] 768066000948 B12 binding domain; Region: B12-binding_2; pfam02607 768066000949 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 768066000950 putative active site [active] 768066000951 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 768066000952 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 768066000953 putative NAD(P) binding site [chemical binding]; other site 768066000954 putative active site [active] 768066000955 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768066000956 nucleoside/Zn binding site; other site 768066000957 dimer interface [polypeptide binding]; other site 768066000958 catalytic motif [active] 768066000959 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768066000960 ATP-dependent helicase HepA; Validated; Region: PRK04914 768066000961 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768066000962 ATP binding site [chemical binding]; other site 768066000963 putative Mg++ binding site [ion binding]; other site 768066000964 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066000965 nucleotide binding region [chemical binding]; other site 768066000966 ATP-binding site [chemical binding]; other site 768066000967 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 768066000968 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768066000969 catalytic residues [active] 768066000970 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768066000971 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768066000972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066000973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768066000974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066000975 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 768066000976 metal-binding site 768066000977 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 768066000978 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768066000979 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768066000980 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768066000981 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768066000982 Cytochrome c; Region: Cytochrom_C; pfam00034 768066000983 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768066000984 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 768066000985 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768066000986 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768066000987 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768066000988 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768066000989 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768066000990 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768066000991 active site 768066000992 catalytic tetrad [active] 768066000993 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768066000994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066000995 putative substrate translocation pore; other site 768066000996 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066000997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066000998 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066000999 dimerization interface [polypeptide binding]; other site 768066001000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066001001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768066001003 dimerization interface [polypeptide binding]; other site 768066001004 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 768066001005 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066001006 inhibitor-cofactor binding pocket; inhibition site 768066001007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066001008 catalytic residue [active] 768066001009 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 768066001010 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 768066001011 tetrameric interface [polypeptide binding]; other site 768066001012 NAD binding site [chemical binding]; other site 768066001013 catalytic residues [active] 768066001014 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 768066001015 PhoH-like protein; Region: PhoH; cl17668 768066001016 AAA domain; Region: AAA_12; pfam13087 768066001017 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768066001018 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 768066001019 NAD(P) binding site [chemical binding]; other site 768066001020 catalytic residues [active] 768066001021 catalytic residues [active] 768066001022 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 768066001023 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768066001024 Na binding site [ion binding]; other site 768066001025 hypothetical protein; Provisional; Region: PRK07524 768066001026 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768066001027 PYR/PP interface [polypeptide binding]; other site 768066001028 dimer interface [polypeptide binding]; other site 768066001029 TPP binding site [chemical binding]; other site 768066001030 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768066001031 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768066001032 TPP-binding site [chemical binding]; other site 768066001033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 768066001034 Nucleoside recognition; Region: Gate; pfam07670 768066001035 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 768066001036 agmatinase; Region: agmatinase; TIGR01230 768066001037 oligomer interface [polypeptide binding]; other site 768066001038 putative active site [active] 768066001039 Mn binding site [ion binding]; other site 768066001040 PAS domain; Region: PAS; smart00091 768066001041 PAS domain; Region: PAS_9; pfam13426 768066001042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066001043 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 768066001044 Walker A motif; other site 768066001045 ATP binding site [chemical binding]; other site 768066001046 Walker B motif; other site 768066001047 arginine finger; other site 768066001048 putative DNA binding site [nucleotide binding]; other site 768066001049 dimerization interface [polypeptide binding]; other site 768066001050 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 768066001051 putative Zn2+ binding site [ion binding]; other site 768066001052 Predicted membrane protein [Function unknown]; Region: COG1288 768066001053 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 768066001054 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 768066001055 allantoate amidohydrolase; Reviewed; Region: PRK12890 768066001056 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768066001057 active site 768066001058 metal binding site [ion binding]; metal-binding site 768066001059 dimer interface [polypeptide binding]; other site 768066001060 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768066001061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066001062 DNA-binding site [nucleotide binding]; DNA binding site 768066001063 FCD domain; Region: FCD; pfam07729 768066001064 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768066001065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768066001066 PAS domain; Region: PAS_9; pfam13426 768066001067 putative active site [active] 768066001068 heme pocket [chemical binding]; other site 768066001069 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768066001070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066001071 Walker A motif; other site 768066001072 ATP binding site [chemical binding]; other site 768066001073 Walker B motif; other site 768066001074 arginine finger; other site 768066001075 Benzoate membrane transport protein; Region: BenE; pfam03594 768066001076 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 768066001077 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768066001078 active site 768066001079 NAD binding site [chemical binding]; other site 768066001080 metal binding site [ion binding]; metal-binding site 768066001081 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 768066001082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066001083 putative substrate translocation pore; other site 768066001084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066001085 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768066001086 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768066001087 substrate binding pocket [chemical binding]; other site 768066001088 chain length determination region; other site 768066001089 substrate-Mg2+ binding site; other site 768066001090 catalytic residues [active] 768066001091 aspartate-rich region 1; other site 768066001092 active site lid residues [active] 768066001093 aspartate-rich region 2; other site 768066001094 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 768066001095 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 768066001096 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 768066001097 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 768066001098 GTP1/OBG; Region: GTP1_OBG; pfam01018 768066001099 Obg GTPase; Region: Obg; cd01898 768066001100 G1 box; other site 768066001101 GTP/Mg2+ binding site [chemical binding]; other site 768066001102 Switch I region; other site 768066001103 G2 box; other site 768066001104 G3 box; other site 768066001105 Switch II region; other site 768066001106 G4 box; other site 768066001107 G5 box; other site 768066001108 gamma-glutamyl kinase; Provisional; Region: PRK05429 768066001109 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 768066001110 nucleotide binding site [chemical binding]; other site 768066001111 homotetrameric interface [polypeptide binding]; other site 768066001112 putative phosphate binding site [ion binding]; other site 768066001113 putative allosteric binding site; other site 768066001114 PUA domain; Region: PUA; pfam01472 768066001115 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 768066001116 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 768066001117 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 768066001118 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 768066001119 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 768066001120 active site 768066001121 Riboflavin kinase; Region: Flavokinase; pfam01687 768066001122 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 768066001123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768066001124 active site 768066001125 HIGH motif; other site 768066001126 nucleotide binding site [chemical binding]; other site 768066001127 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768066001128 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768066001129 active site 768066001130 KMSKS motif; other site 768066001131 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 768066001132 tRNA binding surface [nucleotide binding]; other site 768066001133 anticodon binding site; other site 768066001134 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768066001135 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 768066001136 lipoprotein signal peptidase; Provisional; Region: PRK14787 768066001137 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768066001138 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 768066001139 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 768066001140 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 768066001141 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 768066001142 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 768066001143 Type II transport protein GspH; Region: GspH; pfam12019 768066001144 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 768066001145 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768066001146 NAD synthetase; Provisional; Region: PRK13981 768066001147 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 768066001148 multimer interface [polypeptide binding]; other site 768066001149 active site 768066001150 catalytic triad [active] 768066001151 protein interface 1 [polypeptide binding]; other site 768066001152 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 768066001153 homodimer interface [polypeptide binding]; other site 768066001154 NAD binding pocket [chemical binding]; other site 768066001155 ATP binding pocket [chemical binding]; other site 768066001156 Mg binding site [ion binding]; other site 768066001157 active-site loop [active] 768066001158 Outer membrane lipoprotein; Region: YfiO; pfam13525 768066001159 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 768066001160 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768066001161 RNA binding surface [nucleotide binding]; other site 768066001162 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768066001163 active site 768066001164 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 768066001165 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768066001166 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 768066001167 Clp amino terminal domain; Region: Clp_N; pfam02861 768066001168 Clp amino terminal domain; Region: Clp_N; pfam02861 768066001169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066001170 Walker A motif; other site 768066001171 ATP binding site [chemical binding]; other site 768066001172 Walker B motif; other site 768066001173 arginine finger; other site 768066001174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066001175 Walker A motif; other site 768066001176 ATP binding site [chemical binding]; other site 768066001177 Walker B motif; other site 768066001178 arginine finger; other site 768066001179 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768066001180 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 768066001181 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768066001182 PYR/PP interface [polypeptide binding]; other site 768066001183 dimer interface [polypeptide binding]; other site 768066001184 TPP binding site [chemical binding]; other site 768066001185 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768066001186 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768066001187 TPP-binding site [chemical binding]; other site 768066001188 dimer interface [polypeptide binding]; other site 768066001189 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 768066001190 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768066001191 putative valine binding site [chemical binding]; other site 768066001192 dimer interface [polypeptide binding]; other site 768066001193 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 768066001194 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 768066001195 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768066001196 putative NAD(P) binding site [chemical binding]; other site 768066001197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001198 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 768066001199 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 768066001200 putative dimerization interface [polypeptide binding]; other site 768066001201 ketol-acid reductoisomerase; Provisional; Region: PRK05479 768066001202 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 768066001203 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768066001204 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 768066001205 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 768066001206 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 768066001207 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768066001208 catalytic triad [active] 768066001209 conserved cis-peptide bond; other site 768066001210 hypothetical protein; Validated; Region: PRK02101 768066001211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768066001212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768066001213 active site 768066001214 catalytic tetrad [active] 768066001215 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 768066001216 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 768066001217 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 768066001218 NAD(P) binding site [chemical binding]; other site 768066001219 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768066001220 Protein of unknown function (DUF501); Region: DUF501; pfam04417 768066001221 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 768066001222 putative deacylase active site [active] 768066001223 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768066001224 active site 768066001225 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 768066001226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066001227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066001228 homodimer interface [polypeptide binding]; other site 768066001229 catalytic residue [active] 768066001230 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768066001231 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768066001232 HIGH motif; other site 768066001233 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768066001234 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768066001235 active site 768066001236 KMSKS motif; other site 768066001237 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 768066001238 tRNA binding surface [nucleotide binding]; other site 768066001239 anticodon binding site; other site 768066001240 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 768066001241 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 768066001242 short chain dehydrogenase; Provisional; Region: PRK06123 768066001243 classical (c) SDRs; Region: SDR_c; cd05233 768066001244 NAD(P) binding site [chemical binding]; other site 768066001245 active site 768066001246 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 768066001247 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 768066001248 homodimer interface [polypeptide binding]; other site 768066001249 substrate-cofactor binding pocket; other site 768066001250 catalytic residue [active] 768066001251 multifunctional aminopeptidase A; Provisional; Region: PRK00913 768066001252 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768066001253 interface (dimer of trimers) [polypeptide binding]; other site 768066001254 Substrate-binding/catalytic site; other site 768066001255 Zn-binding sites [ion binding]; other site 768066001256 Predicted permeases [General function prediction only]; Region: COG0795 768066001257 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768066001258 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 768066001259 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768066001260 RDD family; Region: RDD; pfam06271 768066001261 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 768066001262 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 768066001263 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 768066001264 heme binding site [chemical binding]; other site 768066001265 ferroxidase pore; other site 768066001266 ferroxidase diiron center [ion binding]; other site 768066001267 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 768066001268 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 768066001269 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 768066001270 putative ATP binding site [chemical binding]; other site 768066001271 putative substrate interface [chemical binding]; other site 768066001272 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 768066001273 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768066001274 active site 768066001275 NAD-dependent deacetylase; Provisional; Region: PRK00481 768066001276 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 768066001277 NAD+ binding site [chemical binding]; other site 768066001278 substrate binding site [chemical binding]; other site 768066001279 Zn binding site [ion binding]; other site 768066001280 Uncharacterized conserved protein [Function unknown]; Region: COG3148 768066001281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066001282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001283 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768066001284 putative effector binding pocket; other site 768066001285 dimerization interface [polypeptide binding]; other site 768066001286 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 768066001287 Cation transport protein; Region: TrkH; cl17365 768066001288 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768066001289 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 768066001290 TrkA-N domain; Region: TrkA_N; pfam02254 768066001291 TrkA-C domain; Region: TrkA_C; pfam02080 768066001292 TrkA-N domain; Region: TrkA_N; pfam02254 768066001293 TrkA-C domain; Region: TrkA_C; pfam02080 768066001294 Dodecin; Region: Dodecin; pfam07311 768066001295 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 768066001296 16S rRNA methyltransferase B; Provisional; Region: PRK10901 768066001297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066001298 S-adenosylmethionine binding site [chemical binding]; other site 768066001299 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 768066001300 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 768066001301 putative active site [active] 768066001302 substrate binding site [chemical binding]; other site 768066001303 putative cosubstrate binding site; other site 768066001304 catalytic site [active] 768066001305 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 768066001306 substrate binding site [chemical binding]; other site 768066001307 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768066001308 active site 768066001309 catalytic residues [active] 768066001310 metal binding site [ion binding]; metal-binding site 768066001311 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 768066001312 DNA protecting protein DprA; Region: dprA; TIGR00732 768066001313 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 768066001314 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 768066001315 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 768066001316 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 768066001317 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768066001318 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768066001319 NAD(P) binding site [chemical binding]; other site 768066001320 shikimate binding site; other site 768066001321 Peptidase family M48; Region: Peptidase_M48; pfam01435 768066001322 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 768066001323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066001324 Walker A motif; other site 768066001325 ATP binding site [chemical binding]; other site 768066001326 Walker B motif; other site 768066001327 GTP-binding protein Der; Reviewed; Region: PRK00093 768066001328 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 768066001329 G1 box; other site 768066001330 GTP/Mg2+ binding site [chemical binding]; other site 768066001331 Switch I region; other site 768066001332 G2 box; other site 768066001333 Switch II region; other site 768066001334 G3 box; other site 768066001335 G4 box; other site 768066001336 G5 box; other site 768066001337 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 768066001338 G1 box; other site 768066001339 GTP/Mg2+ binding site [chemical binding]; other site 768066001340 Switch I region; other site 768066001341 G2 box; other site 768066001342 G3 box; other site 768066001343 Switch II region; other site 768066001344 G4 box; other site 768066001345 G5 box; other site 768066001346 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 768066001347 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 768066001348 Trp docking motif [polypeptide binding]; other site 768066001349 active site 768066001350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 768066001351 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 768066001352 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 768066001353 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768066001354 dimer interface [polypeptide binding]; other site 768066001355 motif 1; other site 768066001356 active site 768066001357 motif 2; other site 768066001358 motif 3; other site 768066001359 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 768066001360 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768066001361 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768066001362 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 768066001363 Helix-turn-helix domain; Region: HTH_25; pfam13413 768066001364 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 768066001365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768066001366 TPR repeat; Region: TPR_11; pfam13414 768066001367 binding surface 768066001368 TPR motif; other site 768066001369 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768066001370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768066001371 binding surface 768066001372 TPR motif; other site 768066001373 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 768066001374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066001375 FeS/SAM binding site; other site 768066001376 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 768066001377 active site 768066001378 multimer interface [polypeptide binding]; other site 768066001379 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 768066001380 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768066001381 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768066001382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768066001383 catalytic residue [active] 768066001384 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 768066001385 Rrf2 family protein; Region: rrf2_super; TIGR00738 768066001386 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 768066001387 serine O-acetyltransferase; Region: cysE; TIGR01172 768066001388 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768066001389 trimer interface [polypeptide binding]; other site 768066001390 active site 768066001391 substrate binding site [chemical binding]; other site 768066001392 CoA binding site [chemical binding]; other site 768066001393 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 768066001394 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768066001395 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 768066001396 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768066001397 active site 768066001398 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 768066001399 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768066001400 Protein export membrane protein; Region: SecD_SecF; pfam02355 768066001401 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 768066001402 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 768066001403 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768066001404 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 768066001405 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 768066001406 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 768066001407 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 768066001408 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 768066001409 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 768066001410 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 768066001411 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768066001412 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768066001413 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 768066001414 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 768066001415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768066001416 active site 768066001417 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 768066001418 nudix motif; other site 768066001419 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 768066001420 catalytic residues [active] 768066001421 dimer interface [polypeptide binding]; other site 768066001422 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 768066001423 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 768066001424 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 768066001425 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 768066001426 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066001427 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 768066001428 conserved cys residue [active] 768066001429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066001430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066001431 Isochorismatase family; Region: Isochorismatase; pfam00857 768066001432 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768066001433 catalytic triad [active] 768066001434 conserved cis-peptide bond; other site 768066001435 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066001436 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768066001437 conserved cys residue [active] 768066001438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066001439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066001440 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 768066001441 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066001442 inhibitor-cofactor binding pocket; inhibition site 768066001443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066001444 catalytic residue [active] 768066001445 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 768066001446 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 768066001447 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 768066001448 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 768066001449 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 768066001450 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 768066001451 NAD(P) binding site [chemical binding]; other site 768066001452 catalytic residues [active] 768066001453 succinylarginine dihydrolase; Provisional; Region: PRK13281 768066001454 Protein of unknown function (DUF808); Region: DUF808; pfam05661 768066001455 Predicted ATPase [General function prediction only]; Region: COG1485 768066001456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 768066001457 ATP binding site [chemical binding]; other site 768066001458 Walker A/P-loop; other site 768066001459 Q-loop/lid; other site 768066001460 ABC transporter signature motif; other site 768066001461 Walker B; other site 768066001462 D-loop; other site 768066001463 H-loop/switch region; other site 768066001464 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768066001465 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 768066001466 Predicted membrane protein [Function unknown]; Region: COG2860 768066001467 UPF0126 domain; Region: UPF0126; pfam03458 768066001468 UPF0126 domain; Region: UPF0126; pfam03458 768066001469 Domain of unknown function (DUF3541); Region: DUF3541; pfam12060 768066001470 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 768066001471 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768066001472 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 768066001473 Protein of unknown function (DUF3581); Region: DUF3581; pfam12119 768066001474 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 768066001475 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 768066001476 oligomer interface [polypeptide binding]; other site 768066001477 metal binding site [ion binding]; metal-binding site 768066001478 metal binding site [ion binding]; metal-binding site 768066001479 putative Cl binding site [ion binding]; other site 768066001480 aspartate ring; other site 768066001481 basic sphincter; other site 768066001482 hydrophobic gate; other site 768066001483 periplasmic entrance; other site 768066001484 MarR family; Region: MarR_2; cl17246 768066001485 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768066001486 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 768066001487 FMN binding site [chemical binding]; other site 768066001488 dimer interface [polypeptide binding]; other site 768066001489 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 768066001490 amphipathic channel; other site 768066001491 Asn-Pro-Ala signature motifs; other site 768066001492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768066001493 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768066001494 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 768066001495 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 768066001496 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 768066001497 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 768066001498 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066001499 hypothetical protein; Provisional; Region: PRK09256 768066001500 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 768066001501 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 768066001502 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066001503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001504 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 768066001505 putative dimerization interface [polypeptide binding]; other site 768066001506 putative substrate binding pocket [chemical binding]; other site 768066001507 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 768066001508 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 768066001509 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768066001510 NAD(P) binding site [chemical binding]; other site 768066001511 putative active site [active] 768066001512 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 768066001513 putative deacylase active site [active] 768066001514 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 768066001515 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 768066001516 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768066001517 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768066001518 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 768066001519 active site pocket [active] 768066001520 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 768066001521 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768066001522 active site 768066001523 NAD binding site [chemical binding]; other site 768066001524 metal binding site [ion binding]; metal-binding site 768066001525 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 768066001526 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 768066001527 NAD(P) binding site [chemical binding]; other site 768066001528 catalytic residues [active] 768066001529 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066001530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001531 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768066001532 dimerization interface [polypeptide binding]; other site 768066001533 substrate binding pocket [chemical binding]; other site 768066001534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066001535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001536 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066001537 dimerization interface [polypeptide binding]; other site 768066001538 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 768066001539 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768066001540 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768066001541 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 768066001542 active site 768066001543 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 768066001544 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768066001545 OmpW family; Region: OmpW; cl17427 768066001546 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 768066001547 dimer interface [polypeptide binding]; other site 768066001548 FMN binding site [chemical binding]; other site 768066001549 NADPH bind site [chemical binding]; other site 768066001550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066001551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001552 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768066001553 putative effector binding pocket; other site 768066001554 dimerization interface [polypeptide binding]; other site 768066001555 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 768066001556 NmrA-like family; Region: NmrA; pfam05368 768066001557 NADP binding site [chemical binding]; other site 768066001558 active site 768066001559 regulatory binding site [polypeptide binding]; other site 768066001560 short chain dehydrogenase; Provisional; Region: PRK07478 768066001561 classical (c) SDRs; Region: SDR_c; cd05233 768066001562 NAD(P) binding site [chemical binding]; other site 768066001563 active site 768066001564 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 768066001565 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768066001566 DNA binding residues [nucleotide binding] 768066001567 putative dimer interface [polypeptide binding]; other site 768066001568 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768066001569 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 768066001570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066001571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066001572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066001573 putative substrate translocation pore; other site 768066001574 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768066001575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066001576 DNA-binding site [nucleotide binding]; DNA binding site 768066001577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066001578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066001579 homodimer interface [polypeptide binding]; other site 768066001580 catalytic residue [active] 768066001581 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 768066001582 dimer interface [polypeptide binding]; other site 768066001583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066001584 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 768066001585 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 768066001586 Walker A/P-loop; other site 768066001587 ATP binding site [chemical binding]; other site 768066001588 Q-loop/lid; other site 768066001589 ABC transporter signature motif; other site 768066001590 Walker B; other site 768066001591 D-loop; other site 768066001592 H-loop/switch region; other site 768066001593 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 768066001594 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768066001595 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066001596 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 768066001597 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768066001598 putative catalytic site [active] 768066001599 putative metal binding site [ion binding]; other site 768066001600 putative phosphate binding site [ion binding]; other site 768066001601 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 768066001602 Bacterial Ig-like domain 2; Region: BID_2; smart00635 768066001603 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 768066001604 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 768066001605 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 768066001606 generic binding surface II; other site 768066001607 generic binding surface I; other site 768066001608 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 768066001609 putative active site [active] 768066001610 putative catalytic site [active] 768066001611 putative Mg binding site IVb [ion binding]; other site 768066001612 putative phosphate binding site [ion binding]; other site 768066001613 putative DNA binding site [nucleotide binding]; other site 768066001614 putative Mg binding site IVa [ion binding]; other site 768066001615 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768066001616 DNA binding site [nucleotide binding] 768066001617 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 768066001618 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768066001619 putative ligand binding site [chemical binding]; other site 768066001620 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066001621 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066001622 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 768066001623 DctM-like transporters; Region: DctM; pfam06808 768066001624 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066001625 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 768066001626 dimer interface [polypeptide binding]; other site 768066001627 substrate binding site [chemical binding]; other site 768066001628 metal binding site [ion binding]; metal-binding site 768066001629 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 768066001630 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 768066001631 dimer interface [polypeptide binding]; other site 768066001632 active site 768066001633 catalytic residue [active] 768066001634 metal binding site [ion binding]; metal-binding site 768066001635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 768066001636 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 768066001637 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 768066001638 Domain of unknown function (DUF427); Region: DUF427; pfam04248 768066001639 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 768066001640 AAA domain; Region: AAA_30; pfam13604 768066001641 Family description; Region: UvrD_C_2; pfam13538 768066001642 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 768066001643 Family description; Region: UvrD_C_2; pfam13538 768066001644 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 768066001645 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 768066001646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066001647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066001649 dimerization interface [polypeptide binding]; other site 768066001650 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 768066001651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066001652 putative substrate translocation pore; other site 768066001653 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768066001654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066001655 NAD(P) binding site [chemical binding]; other site 768066001656 active site 768066001657 HPP family; Region: HPP; pfam04982 768066001658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066001659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066001660 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 768066001661 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 768066001662 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 768066001663 active site 768066001664 metal binding site [ion binding]; metal-binding site 768066001665 homotetramer interface [polypeptide binding]; other site 768066001666 arsenical pump membrane protein; Provisional; Region: PRK15445 768066001667 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 768066001668 transmembrane helices; other site 768066001669 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768066001670 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768066001671 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768066001672 dimerization interface [polypeptide binding]; other site 768066001673 putative DNA binding site [nucleotide binding]; other site 768066001674 putative Zn2+ binding site [ion binding]; other site 768066001675 malonyl-CoA synthase; Validated; Region: PRK07514 768066001676 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 768066001677 acyl-activating enzyme (AAE) consensus motif; other site 768066001678 active site 768066001679 AMP binding site [chemical binding]; other site 768066001680 CoA binding site [chemical binding]; other site 768066001681 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 768066001682 DctM-like transporters; Region: DctM; pfam06808 768066001683 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066001684 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066001685 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066001686 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066001687 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768066001688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066001689 DNA-binding site [nucleotide binding]; DNA binding site 768066001690 FCD domain; Region: FCD; pfam07729 768066001691 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 768066001692 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 768066001693 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768066001694 DNA binding site [nucleotide binding] 768066001695 active site 768066001696 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 768066001697 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 768066001698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066001699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066001700 AlkA N-terminal domain; Region: AlkA_N; pfam06029 768066001701 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 768066001702 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768066001703 minor groove reading motif; other site 768066001704 helix-hairpin-helix signature motif; other site 768066001705 substrate binding pocket [chemical binding]; other site 768066001706 active site 768066001707 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768066001708 kynureninase; Region: kynureninase; TIGR01814 768066001709 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768066001710 catalytic residue [active] 768066001711 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 768066001712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 768066001713 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 768066001714 hypothetical protein; Validated; Region: PRK00029 768066001715 Uncharacterized conserved protein [Function unknown]; Region: COG0397 768066001716 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768066001717 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 768066001718 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 768066001719 dimer interface [polypeptide binding]; other site 768066001720 active site 768066001721 heme binding site [chemical binding]; other site 768066001722 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 768066001723 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066001724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001725 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066001726 dimerization interface [polypeptide binding]; other site 768066001727 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 768066001728 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 768066001729 tetrameric interface [polypeptide binding]; other site 768066001730 NAD binding site [chemical binding]; other site 768066001731 catalytic residues [active] 768066001732 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 768066001733 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768066001734 Na binding site [ion binding]; other site 768066001735 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768066001736 homotrimer interaction site [polypeptide binding]; other site 768066001737 putative active site [active] 768066001738 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 768066001739 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 768066001740 active site 768066001741 putative substrate binding pocket [chemical binding]; other site 768066001742 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768066001743 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768066001744 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768066001745 putative active site [active] 768066001746 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 768066001747 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 768066001748 dimer interface [polypeptide binding]; other site 768066001749 active site 768066001750 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768066001751 substrate binding site [chemical binding]; other site 768066001752 catalytic residue [active] 768066001753 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768066001754 Na binding site [ion binding]; other site 768066001755 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 768066001756 amino acid transporter; Region: 2A0306; TIGR00909 768066001757 Predicted dehydrogenase [General function prediction only]; Region: COG0579 768066001758 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768066001759 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 768066001760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768066001761 membrane-bound complex binding site; other site 768066001762 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 768066001763 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 768066001764 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 768066001765 AIR carboxylase; Region: AIRC; pfam00731 768066001766 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 768066001767 ATP-grasp domain; Region: ATP-grasp; pfam02222 768066001768 Predicted membrane protein [Function unknown]; Region: COG2855 768066001769 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 768066001770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001771 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768066001772 putative dimerization interface [polypeptide binding]; other site 768066001773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066001774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768066001776 dimerization interface [polypeptide binding]; other site 768066001777 ethanolamine permease; Region: 2A0305; TIGR00908 768066001778 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768066001779 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768066001780 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768066001781 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 768066001782 NAD(P) binding site [chemical binding]; other site 768066001783 catalytic residues [active] 768066001784 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 768066001785 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 768066001786 putative active site [active] 768066001787 metal binding site [ion binding]; metal-binding site 768066001788 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768066001789 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 768066001790 catalytic triad [active] 768066001791 TraX protein; Region: TraX; cl05434 768066001792 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768066001793 Heavy-metal-associated domain; Region: HMA; pfam00403 768066001794 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768066001795 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768066001796 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 768066001797 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 768066001798 DNA binding residues [nucleotide binding] 768066001799 dimer interface [polypeptide binding]; other site 768066001800 putative metal binding site [ion binding]; other site 768066001801 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066001802 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066001803 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066001804 DctM-like transporters; Region: DctM; pfam06808 768066001805 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066001806 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066001807 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 768066001808 conserved cys residue [active] 768066001809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066001810 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768066001811 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768066001812 substrate binding pocket [chemical binding]; other site 768066001813 membrane-bound complex binding site; other site 768066001814 hinge residues; other site 768066001815 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768066001816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066001817 dimer interface [polypeptide binding]; other site 768066001818 conserved gate region; other site 768066001819 putative PBP binding loops; other site 768066001820 ABC-ATPase subunit interface; other site 768066001821 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768066001822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066001823 dimer interface [polypeptide binding]; other site 768066001824 conserved gate region; other site 768066001825 putative PBP binding loops; other site 768066001826 ABC-ATPase subunit interface; other site 768066001827 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 768066001828 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768066001829 Walker A/P-loop; other site 768066001830 ATP binding site [chemical binding]; other site 768066001831 Q-loop/lid; other site 768066001832 ABC transporter signature motif; other site 768066001833 Walker B; other site 768066001834 D-loop; other site 768066001835 H-loop/switch region; other site 768066001836 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 768066001837 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 768066001838 active site 768066001839 Zn binding site [ion binding]; other site 768066001840 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 768066001841 Strictosidine synthase; Region: Str_synth; pfam03088 768066001842 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768066001843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066001844 S-adenosylmethionine binding site [chemical binding]; other site 768066001845 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 768066001846 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768066001847 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 768066001848 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 768066001849 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 768066001850 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066001851 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066001852 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768066001853 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 768066001854 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768066001855 active site 768066001856 dimer interface [polypeptide binding]; other site 768066001857 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768066001858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066001859 DNA-binding site [nucleotide binding]; DNA binding site 768066001860 FCD domain; Region: FCD; pfam07729 768066001861 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768066001862 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768066001863 inhibitor site; inhibition site 768066001864 active site 768066001865 dimer interface [polypeptide binding]; other site 768066001866 catalytic residue [active] 768066001867 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768066001868 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 768066001869 dimer interface [polypeptide binding]; other site 768066001870 NADP binding site [chemical binding]; other site 768066001871 catalytic residues [active] 768066001872 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 768066001873 tartrate dehydrogenase; Region: TTC; TIGR02089 768066001874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001875 transcriptional activator TtdR; Provisional; Region: PRK09801 768066001876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066001877 dimerization interface [polypeptide binding]; other site 768066001878 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768066001879 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 768066001880 putative ADP-binding pocket [chemical binding]; other site 768066001881 Uncharacterized conserved protein [Function unknown]; Region: COG0398 768066001882 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768066001883 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 768066001884 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 768066001885 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 768066001886 Protein of unknown function (DUF971); Region: DUF971; cl01414 768066001887 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 768066001888 substrate binding pocket [chemical binding]; other site 768066001889 active site 768066001890 iron coordination sites [ion binding]; other site 768066001891 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066001892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066001894 dimerization interface [polypeptide binding]; other site 768066001895 Protein of unknown function, DUF; Region: DUF411; cl01142 768066001896 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768066001897 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768066001898 putative metal dependent hydrolase; Provisional; Region: PRK11598 768066001899 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 768066001900 Sulfatase; Region: Sulfatase; pfam00884 768066001901 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768066001902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066001903 active site 768066001904 phosphorylation site [posttranslational modification] 768066001905 intermolecular recognition site; other site 768066001906 dimerization interface [polypeptide binding]; other site 768066001907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066001908 DNA binding site [nucleotide binding] 768066001909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066001910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066001911 dimer interface [polypeptide binding]; other site 768066001912 phosphorylation site [posttranslational modification] 768066001913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066001914 ATP binding site [chemical binding]; other site 768066001915 Mg2+ binding site [ion binding]; other site 768066001916 G-X-G motif; other site 768066001917 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 768066001918 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 768066001919 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768066001920 putative active site [active] 768066001921 catalytic triad [active] 768066001922 putative dimer interface [polypeptide binding]; other site 768066001923 EamA-like transporter family; Region: EamA; pfam00892 768066001924 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768066001925 EamA-like transporter family; Region: EamA; pfam00892 768066001926 BCCT family transporter; Region: BCCT; pfam02028 768066001927 choline-sulfatase; Region: chol_sulfatase; TIGR03417 768066001928 Sulfatase; Region: Sulfatase; cl17466 768066001929 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 768066001930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066001931 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 768066001932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066001933 dimerization interface [polypeptide binding]; other site 768066001934 hypothetical protein; Provisional; Region: PRK11019 768066001935 Domain of unknown function (DUF336); Region: DUF336; cl01249 768066001936 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 768066001937 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768066001938 Cysteine-rich domain; Region: CCG; pfam02754 768066001939 Cysteine-rich domain; Region: CCG; pfam02754 768066001940 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 768066001941 FAD binding domain; Region: FAD_binding_4; pfam01565 768066001942 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 768066001943 FAD binding domain; Region: FAD_binding_4; pfam01565 768066001944 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768066001945 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768066001946 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 768066001947 putative N-terminal domain interface [polypeptide binding]; other site 768066001948 putative dimer interface [polypeptide binding]; other site 768066001949 putative substrate binding pocket (H-site) [chemical binding]; other site 768066001950 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768066001951 active site 768066001952 OHCU decarboxylase; Region: UHCUDC; TIGR03164 768066001953 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 768066001954 active site 768066001955 homotetramer interface [polypeptide binding]; other site 768066001956 Predicted membrane protein [Function unknown]; Region: COG3748 768066001957 Protein of unknown function (DUF989); Region: DUF989; pfam06181 768066001958 Cytochrome c; Region: Cytochrom_C; pfam00034 768066001959 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768066001960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066001961 DNA-binding site [nucleotide binding]; DNA binding site 768066001962 FCD domain; Region: FCD; pfam07729 768066001963 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 768066001964 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 768066001965 Na binding site [ion binding]; other site 768066001966 putative substrate binding site [chemical binding]; other site 768066001967 nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483 768066001968 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 768066001969 Na binding site [ion binding]; other site 768066001970 substrate binding site [chemical binding]; other site 768066001971 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 768066001972 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 768066001973 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 768066001974 active site 768066001975 catalytic site [active] 768066001976 tetramer interface [polypeptide binding]; other site 768066001977 Predicted membrane protein [Function unknown]; Region: COG1288 768066001978 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 768066001979 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 768066001980 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 768066001981 hypothetical protein; Provisional; Region: PRK11171 768066001982 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 768066001983 Cupin domain; Region: Cupin_2; pfam07883 768066001984 glyoxylate carboligase; Provisional; Region: PRK11269 768066001985 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768066001986 PYR/PP interface [polypeptide binding]; other site 768066001987 dimer interface [polypeptide binding]; other site 768066001988 TPP binding site [chemical binding]; other site 768066001989 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768066001990 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 768066001991 TPP-binding site [chemical binding]; other site 768066001992 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 768066001993 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 768066001994 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768066001995 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 768066001996 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 768066001997 MOFRL family; Region: MOFRL; pfam05161 768066001998 pyruvate kinase; Provisional; Region: PRK05826 768066001999 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 768066002000 domain interfaces; other site 768066002001 active site 768066002002 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768066002003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066002004 DNA-binding site [nucleotide binding]; DNA binding site 768066002005 FCD domain; Region: FCD; pfam07729 768066002006 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768066002007 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768066002008 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066002009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066002010 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768066002011 dimerization interface [polypeptide binding]; other site 768066002012 substrate binding pocket [chemical binding]; other site 768066002013 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 768066002014 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 768066002015 tetramer interfaces [polypeptide binding]; other site 768066002016 binuclear metal-binding site [ion binding]; other site 768066002017 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 768066002018 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 768066002019 Chromate transporter; Region: Chromate_transp; pfam02417 768066002020 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 768066002021 Ion transport protein; Region: Ion_trans; pfam00520 768066002022 Ion channel; Region: Ion_trans_2; pfam07885 768066002023 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 768066002024 putative active site [active] 768066002025 putative metal binding residues [ion binding]; other site 768066002026 signature motif; other site 768066002027 putative triphosphate binding site [ion binding]; other site 768066002028 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 768066002029 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768066002030 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768066002031 N-acetylglutamate synthase; Validated; Region: PRK05279 768066002032 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 768066002033 putative feedback inhibition sensing region; other site 768066002034 putative nucleotide binding site [chemical binding]; other site 768066002035 putative substrate binding site [chemical binding]; other site 768066002036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066002037 Coenzyme A binding pocket [chemical binding]; other site 768066002038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066002039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066002040 dimer interface [polypeptide binding]; other site 768066002041 phosphorylation site [posttranslational modification] 768066002042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066002043 ATP binding site [chemical binding]; other site 768066002044 Mg2+ binding site [ion binding]; other site 768066002045 G-X-G motif; other site 768066002046 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 768066002047 response regulator GlrR; Provisional; Region: PRK15115 768066002048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066002049 active site 768066002050 phosphorylation site [posttranslational modification] 768066002051 intermolecular recognition site; other site 768066002052 dimerization interface [polypeptide binding]; other site 768066002053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066002054 Walker A motif; other site 768066002055 ATP binding site [chemical binding]; other site 768066002056 Walker B motif; other site 768066002057 arginine finger; other site 768066002058 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768066002059 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 768066002060 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 768066002061 generic binding surface II; other site 768066002062 generic binding surface I; other site 768066002063 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768066002064 Putative ammonia monooxygenase; Region: AmoA; pfam05145 768066002065 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768066002066 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 768066002067 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768066002068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768066002069 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 768066002070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066002071 active site 768066002072 phosphorylation site [posttranslational modification] 768066002073 intermolecular recognition site; other site 768066002074 dimerization interface [polypeptide binding]; other site 768066002075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 768066002076 DNA binding site [nucleotide binding] 768066002077 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 768066002078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066002079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066002080 dimer interface [polypeptide binding]; other site 768066002081 phosphorylation site [posttranslational modification] 768066002082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066002083 ATP binding site [chemical binding]; other site 768066002084 Mg2+ binding site [ion binding]; other site 768066002085 G-X-G motif; other site 768066002086 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768066002087 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 768066002088 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 768066002089 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768066002090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 768066002091 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768066002092 active site 768066002093 GMP synthase; Reviewed; Region: guaA; PRK00074 768066002094 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 768066002095 AMP/PPi binding site [chemical binding]; other site 768066002096 candidate oxyanion hole; other site 768066002097 catalytic triad [active] 768066002098 potential glutamine specificity residues [chemical binding]; other site 768066002099 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 768066002100 ATP Binding subdomain [chemical binding]; other site 768066002101 Ligand Binding sites [chemical binding]; other site 768066002102 Dimerization subdomain; other site 768066002103 Isochorismatase family; Region: Isochorismatase; pfam00857 768066002104 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768066002105 catalytic triad [active] 768066002106 conserved cis-peptide bond; other site 768066002107 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 768066002108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066002109 S-adenosylmethionine binding site [chemical binding]; other site 768066002110 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 768066002111 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 768066002112 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768066002113 ligand binding site [chemical binding]; other site 768066002114 flexible hinge region; other site 768066002115 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768066002116 putative switch regulator; other site 768066002117 non-specific DNA interactions [nucleotide binding]; other site 768066002118 DNA binding site [nucleotide binding] 768066002119 sequence specific DNA binding site [nucleotide binding]; other site 768066002120 putative cAMP binding site [chemical binding]; other site 768066002121 putative protease; Provisional; Region: PRK15447 768066002122 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768066002123 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768066002124 Peptidase family U32; Region: Peptidase_U32; pfam01136 768066002125 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 768066002126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066002127 FeS/SAM binding site; other site 768066002128 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 768066002129 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 768066002130 Class III ribonucleotide reductase; Region: RNR_III; cd01675 768066002131 effector binding site; other site 768066002132 active site 768066002133 Zn binding site [ion binding]; other site 768066002134 SCP-2 sterol transfer family; Region: SCP2; cl01225 768066002135 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 768066002136 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768066002137 putative S-transferase; Provisional; Region: PRK11752 768066002138 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 768066002139 C-terminal domain interface [polypeptide binding]; other site 768066002140 GSH binding site (G-site) [chemical binding]; other site 768066002141 dimer interface [polypeptide binding]; other site 768066002142 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 768066002143 dimer interface [polypeptide binding]; other site 768066002144 N-terminal domain interface [polypeptide binding]; other site 768066002145 active site 768066002146 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768066002147 DNA-binding site [nucleotide binding]; DNA binding site 768066002148 RNA-binding motif; other site 768066002149 Cupin domain; Region: Cupin_2; cl17218 768066002150 Helix-turn-helix domain; Region: HTH_18; pfam12833 768066002151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066002152 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768066002153 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 768066002154 dimer interface [polypeptide binding]; other site 768066002155 catalytic triad [active] 768066002156 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 768066002157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066002158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066002159 dimerization interface [polypeptide binding]; other site 768066002160 Lysine efflux permease [General function prediction only]; Region: COG1279 768066002161 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 768066002162 NlpE N-terminal domain; Region: NlpE; pfam04170 768066002163 META domain; Region: META; pfam03724 768066002164 hypothetical protein; Provisional; Region: PRK12378 768066002165 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768066002166 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768066002167 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 768066002168 active site 768066002169 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768066002170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768066002171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066002172 Walker A/P-loop; other site 768066002173 ATP binding site [chemical binding]; other site 768066002174 Q-loop/lid; other site 768066002175 ABC transporter signature motif; other site 768066002176 Walker B; other site 768066002177 D-loop; other site 768066002178 H-loop/switch region; other site 768066002179 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 768066002180 homotrimer interaction site [polypeptide binding]; other site 768066002181 putative active site [active] 768066002182 YrhK-like protein; Region: YrhK; pfam14145 768066002183 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 768066002184 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 768066002185 CHASE2 domain; Region: CHASE2; pfam05226 768066002186 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 768066002187 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 768066002188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066002189 dimer interface [polypeptide binding]; other site 768066002190 phosphorylation site [posttranslational modification] 768066002191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066002192 ATP binding site [chemical binding]; other site 768066002193 Mg2+ binding site [ion binding]; other site 768066002194 G-X-G motif; other site 768066002195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 768066002196 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768066002197 FecR protein; Region: FecR; pfam04773 768066002198 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 768066002199 trimer interface [polypeptide binding]; other site 768066002200 Haemagglutinin; Region: HIM; pfam05662 768066002201 YadA-like C-terminal region; Region: YadA; pfam03895 768066002202 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768066002203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066002204 active site 768066002205 phosphorylation site [posttranslational modification] 768066002206 intermolecular recognition site; other site 768066002207 dimerization interface [polypeptide binding]; other site 768066002208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066002209 DNA binding site [nucleotide binding] 768066002210 Nitronate monooxygenase; Region: NMO; pfam03060 768066002211 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 768066002212 FMN binding site [chemical binding]; other site 768066002213 substrate binding site [chemical binding]; other site 768066002214 putative catalytic residue [active] 768066002215 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768066002216 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 768066002217 putative dimer interface [polypeptide binding]; other site 768066002218 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 768066002219 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 768066002220 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768066002221 active site 768066002222 catalytic residues [active] 768066002223 DNA binding site [nucleotide binding] 768066002224 Int/Topo IB signature motif; other site 768066002225 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 768066002226 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 768066002227 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 768066002228 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 768066002229 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 768066002230 active site 768066002231 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 768066002232 catalytic triad [active] 768066002233 dimer interface [polypeptide binding]; other site 768066002234 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768066002235 nucleoside/Zn binding site; other site 768066002236 dimer interface [polypeptide binding]; other site 768066002237 catalytic motif [active] 768066002238 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 768066002239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768066002240 membrane-bound complex binding site; other site 768066002241 hinge residues; other site 768066002242 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768066002243 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768066002244 catalytic residue [active] 768066002245 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 768066002246 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 768066002247 dimerization interface [polypeptide binding]; other site 768066002248 ATP binding site [chemical binding]; other site 768066002249 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 768066002250 dimerization interface [polypeptide binding]; other site 768066002251 ATP binding site [chemical binding]; other site 768066002252 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 768066002253 putative active site [active] 768066002254 catalytic triad [active] 768066002255 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 768066002256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768066002257 ATP binding site [chemical binding]; other site 768066002258 putative Mg++ binding site [ion binding]; other site 768066002259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066002260 nucleotide binding region [chemical binding]; other site 768066002261 ATP-binding site [chemical binding]; other site 768066002262 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768066002263 substrate binding site [chemical binding]; other site 768066002264 oxyanion hole (OAH) forming residues; other site 768066002265 trimer interface [polypeptide binding]; other site 768066002266 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 768066002267 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 768066002268 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 768066002269 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768066002270 RNA binding surface [nucleotide binding]; other site 768066002271 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 768066002272 probable active site [active] 768066002273 quinolinate synthetase; Provisional; Region: PRK09375 768066002274 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 768066002275 putative oxidoreductase; Provisional; Region: PRK11579 768066002276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768066002277 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768066002278 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 768066002279 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768066002280 dimer interface [polypeptide binding]; other site 768066002281 ADP-ribose binding site [chemical binding]; other site 768066002282 active site 768066002283 nudix motif; other site 768066002284 metal binding site [ion binding]; metal-binding site 768066002285 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 768066002286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066002287 motif II; other site 768066002288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768066002289 RNA binding surface [nucleotide binding]; other site 768066002290 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 768066002291 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 768066002292 dimerization interface [polypeptide binding]; other site 768066002293 domain crossover interface; other site 768066002294 redox-dependent activation switch; other site 768066002295 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768066002296 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768066002297 active site 768066002298 substrate-binding site [chemical binding]; other site 768066002299 metal-binding site [ion binding] 768066002300 ATP binding site [chemical binding]; other site 768066002301 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 768066002302 SelR domain; Region: SelR; pfam01641 768066002303 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 768066002304 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 768066002305 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 768066002306 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 768066002307 RNA binding site [nucleotide binding]; other site 768066002308 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 768066002309 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 768066002310 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478 768066002311 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768066002312 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768066002313 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066002314 malate dehydrogenase; Provisional; Region: PRK05442 768066002315 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 768066002316 NAD(P) binding site [chemical binding]; other site 768066002317 dimer interface [polypeptide binding]; other site 768066002318 malate binding site [chemical binding]; other site 768066002319 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 768066002320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066002321 motif II; other site 768066002322 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 768066002323 putative active site [active] 768066002324 Ap4A binding site [chemical binding]; other site 768066002325 nudix motif; other site 768066002326 putative metal binding site [ion binding]; other site 768066002327 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 768066002328 GAF domain; Region: GAF; pfam01590 768066002329 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768066002330 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768066002331 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768066002332 NRDE protein; Region: NRDE; cl01315 768066002333 Response regulator receiver domain; Region: Response_reg; pfam00072 768066002334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066002335 active site 768066002336 phosphorylation site [posttranslational modification] 768066002337 intermolecular recognition site; other site 768066002338 dimerization interface [polypeptide binding]; other site 768066002339 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768066002340 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 768066002341 thymidylate synthase; Reviewed; Region: thyA; PRK01827 768066002342 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 768066002343 dimerization interface [polypeptide binding]; other site 768066002344 active site 768066002345 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 768066002346 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 768066002347 folate binding site [chemical binding]; other site 768066002348 NADP+ binding site [chemical binding]; other site 768066002349 ProQ/FINO family; Region: ProQ; pfam04352 768066002350 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768066002351 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768066002352 trimer interface [polypeptide binding]; other site 768066002353 eyelet of channel; other site 768066002354 Cache domain; Region: Cache_1; pfam02743 768066002355 HAMP domain; Region: HAMP; pfam00672 768066002356 PAS domain S-box; Region: sensory_box; TIGR00229 768066002357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768066002358 putative active site [active] 768066002359 heme pocket [chemical binding]; other site 768066002360 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768066002361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768066002362 metal binding site [ion binding]; metal-binding site 768066002363 active site 768066002364 I-site; other site 768066002365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768066002366 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768066002367 S-adenosylmethionine binding site [chemical binding]; other site 768066002368 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 768066002369 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 768066002370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066002371 S-adenosylmethionine binding site [chemical binding]; other site 768066002372 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 768066002373 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768066002374 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768066002375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768066002376 TPR motif; other site 768066002377 binding surface 768066002378 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 768066002379 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768066002380 dimer interface [polypeptide binding]; other site 768066002381 ADP-ribose binding site [chemical binding]; other site 768066002382 active site 768066002383 nudix motif; other site 768066002384 metal binding site [ion binding]; metal-binding site 768066002385 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 768066002386 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 768066002387 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768066002388 active site 768066002389 metal binding site [ion binding]; metal-binding site 768066002390 hexamer interface [polypeptide binding]; other site 768066002391 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 768066002392 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768066002393 Active Sites [active] 768066002394 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 768066002395 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 768066002396 CysD dimerization site [polypeptide binding]; other site 768066002397 G1 box; other site 768066002398 putative GEF interaction site [polypeptide binding]; other site 768066002399 GTP/Mg2+ binding site [chemical binding]; other site 768066002400 Switch I region; other site 768066002401 G2 box; other site 768066002402 G3 box; other site 768066002403 Switch II region; other site 768066002404 G4 box; other site 768066002405 G5 box; other site 768066002406 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 768066002407 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 768066002408 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768066002409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066002410 S-adenosylmethionine binding site [chemical binding]; other site 768066002411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066002412 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 768066002413 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768066002414 active site 768066002415 dimer interface [polypeptide binding]; other site 768066002416 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768066002417 dimer interface [polypeptide binding]; other site 768066002418 active site 768066002419 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 768066002420 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 768066002421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066002422 Mg2+ binding site [ion binding]; other site 768066002423 G-X-G motif; other site 768066002424 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768066002425 anchoring element; other site 768066002426 dimer interface [polypeptide binding]; other site 768066002427 ATP binding site [chemical binding]; other site 768066002428 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 768066002429 active site 768066002430 metal binding site [ion binding]; metal-binding site 768066002431 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768066002432 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 768066002433 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768066002434 CAP-like domain; other site 768066002435 active site 768066002436 primary dimer interface [polypeptide binding]; other site 768066002437 ACT domain; Region: ACT_6; pfam13740 768066002438 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 768066002439 phosphoserine phosphatase SerB; Region: serB; TIGR00338 768066002440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066002441 motif II; other site 768066002442 Ion transport protein; Region: Ion_trans; pfam00520 768066002443 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 768066002444 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 768066002445 active site 768066002446 Zn binding site [ion binding]; other site 768066002447 2-isopropylmalate synthase; Validated; Region: PRK03739 768066002448 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 768066002449 active site 768066002450 catalytic residues [active] 768066002451 metal binding site [ion binding]; metal-binding site 768066002452 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 768066002453 Radical SAM superfamily; Region: Radical_SAM; pfam04055 768066002454 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066002455 FeS/SAM binding site; other site 768066002456 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768066002457 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 768066002458 motif 1; other site 768066002459 dimer interface [polypeptide binding]; other site 768066002460 active site 768066002461 motif 2; other site 768066002462 motif 3; other site 768066002463 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 768066002464 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 768066002465 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768066002466 active site residue [active] 768066002467 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768066002468 active site residue [active] 768066002469 GTPase RsgA; Reviewed; Region: PRK12288 768066002470 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768066002471 RNA binding site [nucleotide binding]; other site 768066002472 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 768066002473 GTPase/Zn-binding domain interface [polypeptide binding]; other site 768066002474 GTP/Mg2+ binding site [chemical binding]; other site 768066002475 G4 box; other site 768066002476 G5 box; other site 768066002477 G1 box; other site 768066002478 Switch I region; other site 768066002479 G2 box; other site 768066002480 G3 box; other site 768066002481 Switch II region; other site 768066002482 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 768066002483 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 768066002484 catalytic site [active] 768066002485 putative active site [active] 768066002486 putative substrate binding site [chemical binding]; other site 768066002487 dimer interface [polypeptide binding]; other site 768066002488 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 768066002489 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 768066002490 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768066002491 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768066002492 catalytic residues [active] 768066002493 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 768066002494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066002495 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 768066002496 substrate binding site [chemical binding]; other site 768066002497 dimerization interface [polypeptide binding]; other site 768066002498 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768066002499 Active Sites [active] 768066002500 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 768066002501 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768066002502 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768066002503 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768066002504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066002505 DNA-binding site [nucleotide binding]; DNA binding site 768066002506 FCD domain; Region: FCD; pfam07729 768066002507 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 768066002508 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768066002509 tetramer interface [polypeptide binding]; other site 768066002510 active site 768066002511 Mg2+/Mn2+ binding site [ion binding]; other site 768066002512 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 768066002513 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 768066002514 dimer interface [polypeptide binding]; other site 768066002515 active site 768066002516 citrylCoA binding site [chemical binding]; other site 768066002517 oxalacetate/citrate binding site [chemical binding]; other site 768066002518 coenzyme A binding site [chemical binding]; other site 768066002519 catalytic triad [active] 768066002520 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 768066002521 2-methylcitrate dehydratase; Region: prpD; TIGR02330 768066002522 BCCT family transporter; Region: BCCT; pfam02028 768066002523 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 768066002524 FtsJ-like methyltransferase; Region: FtsJ; cl17430 768066002525 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 768066002526 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 768066002527 CPxP motif; other site 768066002528 Protein of unknown function (DUF3080); Region: DUF3080; pfam11279 768066002529 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 768066002530 multidrug efflux protein; Reviewed; Region: PRK01766 768066002531 cation binding site [ion binding]; other site 768066002532 Protein of unknown function, DUF462; Region: DUF462; pfam04315 768066002533 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768066002534 active site 768066002535 ABC transporter ATPase component; Reviewed; Region: PRK11147 768066002536 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768066002537 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768066002538 ABC transporter; Region: ABC_tran_2; pfam12848 768066002539 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768066002540 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768066002541 Ligand Binding Site [chemical binding]; other site 768066002542 transcriptional regulator SlyA; Provisional; Region: PRK03573 768066002543 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 768066002544 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 768066002545 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 768066002546 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768066002547 substrate binding site [chemical binding]; other site 768066002548 oxyanion hole (OAH) forming residues; other site 768066002549 trimer interface [polypeptide binding]; other site 768066002550 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768066002551 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768066002552 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768066002553 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 768066002554 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768066002555 dimer interface [polypeptide binding]; other site 768066002556 active site 768066002557 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768066002558 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 768066002559 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 768066002560 substrate binding site [chemical binding]; other site 768066002561 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 768066002562 Protein of unknown function, DUF393; Region: DUF393; pfam04134 768066002563 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 768066002564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066002565 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768066002566 dimerization interface [polypeptide binding]; other site 768066002567 substrate binding pocket [chemical binding]; other site 768066002568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768066002569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768066002570 active site 768066002571 catalytic tetrad [active] 768066002572 putative cyanate transporter; Provisional; Region: cynX; PRK09705 768066002573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066002574 putative substrate translocation pore; other site 768066002575 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 768066002576 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 768066002577 DNA binding residues [nucleotide binding] 768066002578 dimer interface [polypeptide binding]; other site 768066002579 [2Fe-2S] cluster binding site [ion binding]; other site 768066002580 Predicted flavoprotein [General function prediction only]; Region: COG0431 768066002581 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768066002582 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768066002583 amino acid carrier protein; Region: agcS; TIGR00835 768066002584 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768066002585 nucleoside/Zn binding site; other site 768066002586 dimer interface [polypeptide binding]; other site 768066002587 catalytic motif [active] 768066002588 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 768066002589 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 768066002590 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 768066002591 PhnA protein; Region: PhnA; pfam03831 768066002592 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 768066002593 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768066002594 putative NAD(P) binding site [chemical binding]; other site 768066002595 active site 768066002596 Prostaglandin dehydrogenases; Region: PGDH; cd05288 768066002597 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 768066002598 NAD(P) binding site [chemical binding]; other site 768066002599 substrate binding site [chemical binding]; other site 768066002600 dimer interface [polypeptide binding]; other site 768066002601 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768066002602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066002603 DNA-binding site [nucleotide binding]; DNA binding site 768066002604 FCD domain; Region: FCD; pfam07729 768066002605 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066002606 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066002607 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066002608 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768066002609 DctM-like transporters; Region: DctM; pfam06808 768066002610 galactonate dehydratase; Provisional; Region: PRK14017 768066002611 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 768066002612 putative active site pocket [active] 768066002613 putative metal binding site [ion binding]; other site 768066002614 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 768066002615 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768066002616 active site 768066002617 intersubunit interface [polypeptide binding]; other site 768066002618 catalytic residue [active] 768066002619 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 768066002620 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 768066002621 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 768066002622 AAA domain; Region: AAA_33; pfam13671 768066002623 ATP-binding site [chemical binding]; other site 768066002624 Gluconate-6-phosphate binding site [chemical binding]; other site 768066002625 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 768066002626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768066002627 putative DNA binding site [nucleotide binding]; other site 768066002628 putative Zn2+ binding site [ion binding]; other site 768066002629 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 768066002630 putative ABC transporter; Region: ycf24; CHL00085 768066002631 FeS assembly ATPase SufC; Region: sufC; TIGR01978 768066002632 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 768066002633 Walker A/P-loop; other site 768066002634 ATP binding site [chemical binding]; other site 768066002635 Q-loop/lid; other site 768066002636 ABC transporter signature motif; other site 768066002637 Walker B; other site 768066002638 D-loop; other site 768066002639 H-loop/switch region; other site 768066002640 FeS assembly protein SufD; Region: sufD; TIGR01981 768066002641 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 768066002642 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 768066002643 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 768066002644 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768066002645 catalytic residue [active] 768066002646 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 768066002647 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768066002648 putative active site [active] 768066002649 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 768066002650 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 768066002651 RimK-like ATP-grasp domain; Region: RimK; pfam08443 768066002652 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 768066002653 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 768066002654 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768066002655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768066002656 substrate binding pocket [chemical binding]; other site 768066002657 membrane-bound complex binding site; other site 768066002658 hinge residues; other site 768066002659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066002660 dimer interface [polypeptide binding]; other site 768066002661 conserved gate region; other site 768066002662 putative PBP binding loops; other site 768066002663 ABC-ATPase subunit interface; other site 768066002664 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768066002665 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768066002666 Walker A/P-loop; other site 768066002667 ATP binding site [chemical binding]; other site 768066002668 Q-loop/lid; other site 768066002669 ABC transporter signature motif; other site 768066002670 Walker B; other site 768066002671 D-loop; other site 768066002672 H-loop/switch region; other site 768066002673 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 768066002674 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768066002675 putative active site pocket [active] 768066002676 dimerization interface [polypeptide binding]; other site 768066002677 putative catalytic residue [active] 768066002678 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 768066002679 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 768066002680 Na binding site [ion binding]; other site 768066002681 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 768066002682 Proline dehydrogenase; Region: Pro_dh; pfam01619 768066002683 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 768066002684 Glutamate binding site [chemical binding]; other site 768066002685 NAD binding site [chemical binding]; other site 768066002686 catalytic residues [active] 768066002687 Cupin domain; Region: Cupin_2; cl17218 768066002688 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768066002689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066002690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066002691 FOG: CBS domain [General function prediction only]; Region: COG0517 768066002692 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 768066002693 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768066002694 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 768066002695 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 768066002696 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768066002697 active site 768066002698 metal binding site [ion binding]; metal-binding site 768066002699 intramembrane serine protease GlpG; Provisional; Region: PRK10907 768066002700 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 768066002701 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 768066002702 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 768066002703 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768066002704 putative C-terminal domain interface [polypeptide binding]; other site 768066002705 putative GSH binding site (G-site) [chemical binding]; other site 768066002706 putative dimer interface [polypeptide binding]; other site 768066002707 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 768066002708 putative substrate binding pocket (H-site) [chemical binding]; other site 768066002709 putative N-terminal domain interface [polypeptide binding]; other site 768066002710 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 768066002711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066002712 FeS/SAM binding site; other site 768066002713 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 768066002714 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 768066002715 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 768066002716 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 768066002717 putative dimer interface [polypeptide binding]; other site 768066002718 active site pocket [active] 768066002719 putative cataytic base [active] 768066002720 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 768066002721 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 768066002722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066002723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066002724 homodimer interface [polypeptide binding]; other site 768066002725 catalytic residue [active] 768066002726 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 768066002727 cobalamin synthase; Reviewed; Region: cobS; PRK00235 768066002728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768066002729 catalytic core [active] 768066002730 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 768066002731 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 768066002732 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066002733 N-terminal plug; other site 768066002734 ligand-binding site [chemical binding]; other site 768066002735 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 768066002736 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 768066002737 cobalamin binding residues [chemical binding]; other site 768066002738 putative BtuC binding residues; other site 768066002739 dimer interface [polypeptide binding]; other site 768066002740 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768066002741 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066002742 dimer interface [polypeptide binding]; other site 768066002743 putative PBP binding regions; other site 768066002744 ABC-ATPase subunit interface; other site 768066002745 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768066002746 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768066002747 Walker A/P-loop; other site 768066002748 ATP binding site [chemical binding]; other site 768066002749 Q-loop/lid; other site 768066002750 ABC transporter signature motif; other site 768066002751 Walker B; other site 768066002752 D-loop; other site 768066002753 H-loop/switch region; other site 768066002754 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768066002755 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768066002756 Walker A/P-loop; other site 768066002757 ATP binding site [chemical binding]; other site 768066002758 Q-loop/lid; other site 768066002759 ABC transporter signature motif; other site 768066002760 Walker B; other site 768066002761 D-loop; other site 768066002762 H-loop/switch region; other site 768066002763 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768066002764 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768066002765 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066002766 dimer interface [polypeptide binding]; other site 768066002767 putative PBP binding regions; other site 768066002768 ABC-ATPase subunit interface; other site 768066002769 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 768066002770 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 768066002771 putative ligand binding residues [chemical binding]; other site 768066002772 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 768066002773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066002774 Walker A motif; other site 768066002775 ATP binding site [chemical binding]; other site 768066002776 Walker B motif; other site 768066002777 arginine finger; other site 768066002778 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 768066002779 metal ion-dependent adhesion site (MIDAS); other site 768066002780 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 768066002781 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 768066002782 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 768066002783 catalytic triad [active] 768066002784 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 768066002785 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768066002786 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 768066002787 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 768066002788 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 768066002789 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 768066002790 precorrin-3B synthase; Region: CobG; TIGR02435 768066002791 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768066002792 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 768066002793 Precorrin-8X methylmutase; Region: CbiC; pfam02570 768066002794 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 768066002795 active site 768066002796 SAM binding site [chemical binding]; other site 768066002797 homodimer interface [polypeptide binding]; other site 768066002798 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 768066002799 active site 768066002800 SAM binding site [chemical binding]; other site 768066002801 homodimer interface [polypeptide binding]; other site 768066002802 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 768066002803 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 768066002804 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 768066002805 active site 768066002806 putative homodimer interface [polypeptide binding]; other site 768066002807 SAM binding site [chemical binding]; other site 768066002808 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 768066002809 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 768066002810 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 768066002811 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 768066002812 active site 768066002813 SAM binding site [chemical binding]; other site 768066002814 homodimer interface [polypeptide binding]; other site 768066002815 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 768066002816 active site 768066002817 SAM binding site [chemical binding]; other site 768066002818 homodimer interface [polypeptide binding]; other site 768066002819 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 768066002820 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 768066002821 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 768066002822 putative FMN binding site [chemical binding]; other site 768066002823 cobyric acid synthase; Provisional; Region: PRK00784 768066002824 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 768066002825 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 768066002826 catalytic triad [active] 768066002827 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 768066002828 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 768066002829 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 768066002830 putative active site [active] 768066002831 catalytic site [active] 768066002832 putative metal binding site [ion binding]; other site 768066002833 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768066002834 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768066002835 Walker A/P-loop; other site 768066002836 ATP binding site [chemical binding]; other site 768066002837 Q-loop/lid; other site 768066002838 ABC transporter signature motif; other site 768066002839 Walker B; other site 768066002840 D-loop; other site 768066002841 H-loop/switch region; other site 768066002842 TOBE domain; Region: TOBE_2; pfam08402 768066002843 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768066002844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066002845 dimer interface [polypeptide binding]; other site 768066002846 conserved gate region; other site 768066002847 putative PBP binding loops; other site 768066002848 ABC-ATPase subunit interface; other site 768066002849 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768066002850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066002851 ABC-ATPase subunit interface; other site 768066002852 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768066002853 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768066002854 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 768066002855 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 768066002856 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 768066002857 NADP binding site [chemical binding]; other site 768066002858 dimer interface [polypeptide binding]; other site 768066002859 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768066002860 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768066002861 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768066002862 putative active site [active] 768066002863 hypothetical protein; Provisional; Region: PRK07483 768066002864 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066002865 inhibitor-cofactor binding pocket; inhibition site 768066002866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066002867 catalytic residue [active] 768066002868 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 768066002869 transmembrane helices; other site 768066002870 TrkA-C domain; Region: TrkA_C; pfam02080 768066002871 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768066002872 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 768066002873 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 768066002874 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 768066002875 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 768066002876 active site 768066002877 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 768066002878 choline dehydrogenase; Validated; Region: PRK02106 768066002879 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768066002880 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 768066002881 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 768066002882 NAD(P) binding site [chemical binding]; other site 768066002883 catalytic residues [active] 768066002884 transcriptional regulator BetI; Validated; Region: PRK00767 768066002885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066002886 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768066002887 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 768066002888 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 768066002889 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 768066002890 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 768066002891 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 768066002892 Multicopper oxidase; Region: Cu-oxidase; pfam00394 768066002893 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 768066002894 sensor protein PhoQ; Provisional; Region: PRK10815 768066002895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066002896 ATP binding site [chemical binding]; other site 768066002897 Mg2+ binding site [ion binding]; other site 768066002898 G-X-G motif; other site 768066002899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066002900 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 768066002901 active site 768066002902 phosphorylation site [posttranslational modification] 768066002903 intermolecular recognition site; other site 768066002904 dimerization interface [polypeptide binding]; other site 768066002905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066002906 DNA binding site [nucleotide binding] 768066002907 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 768066002908 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768066002909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066002910 putative substrate translocation pore; other site 768066002911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066002912 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768066002913 salt bridge; other site 768066002914 non-specific DNA binding site [nucleotide binding]; other site 768066002915 sequence-specific DNA binding site [nucleotide binding]; other site 768066002916 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768066002917 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 768066002918 active site 768066002919 catalytic triad [active] 768066002920 oxyanion hole [active] 768066002921 carboxy-terminal protease; Provisional; Region: PRK11186 768066002922 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 768066002923 protein binding site [polypeptide binding]; other site 768066002924 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 768066002925 Catalytic dyad [active] 768066002926 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 768066002927 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 768066002928 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 768066002929 active site 768066002930 metal binding site [ion binding]; metal-binding site 768066002931 GTP-binding protein YchF; Reviewed; Region: PRK09601 768066002932 YchF GTPase; Region: YchF; cd01900 768066002933 G1 box; other site 768066002934 GTP/Mg2+ binding site [chemical binding]; other site 768066002935 Switch I region; other site 768066002936 G2 box; other site 768066002937 Switch II region; other site 768066002938 G3 box; other site 768066002939 G4 box; other site 768066002940 G5 box; other site 768066002941 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 768066002942 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 768066002943 putative active site [active] 768066002944 catalytic residue [active] 768066002945 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 768066002946 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 768066002947 5S rRNA interface [nucleotide binding]; other site 768066002948 CTC domain interface [polypeptide binding]; other site 768066002949 L16 interface [polypeptide binding]; other site 768066002950 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 768066002951 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 768066002952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768066002953 active site 768066002954 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 768066002955 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768066002956 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 768066002957 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 768066002958 TPR repeat; Region: TPR_11; pfam13414 768066002959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768066002960 binding surface 768066002961 TPR motif; other site 768066002962 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 768066002963 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 768066002964 tRNA; other site 768066002965 putative tRNA binding site [nucleotide binding]; other site 768066002966 putative NADP binding site [chemical binding]; other site 768066002967 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 768066002968 peptide chain release factor 1; Validated; Region: prfA; PRK00591 768066002969 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768066002970 RF-1 domain; Region: RF-1; pfam00472 768066002971 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 768066002972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066002973 S-adenosylmethionine binding site [chemical binding]; other site 768066002974 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 768066002975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768066002976 putative DNA binding site [nucleotide binding]; other site 768066002977 putative Zn2+ binding site [ion binding]; other site 768066002978 AsnC family; Region: AsnC_trans_reg; pfam01037 768066002979 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 768066002980 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 768066002981 ATP binding site [chemical binding]; other site 768066002982 substrate interface [chemical binding]; other site 768066002983 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768066002984 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768066002985 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768066002986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066002987 Walker A/P-loop; other site 768066002988 ATP binding site [chemical binding]; other site 768066002989 Q-loop/lid; other site 768066002990 ABC transporter signature motif; other site 768066002991 Walker B; other site 768066002992 D-loop; other site 768066002993 H-loop/switch region; other site 768066002994 TOBE domain; Region: TOBE_2; pfam08402 768066002995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066002996 dimer interface [polypeptide binding]; other site 768066002997 conserved gate region; other site 768066002998 putative PBP binding loops; other site 768066002999 ABC-ATPase subunit interface; other site 768066003000 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768066003001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066003002 dimer interface [polypeptide binding]; other site 768066003003 conserved gate region; other site 768066003004 putative PBP binding loops; other site 768066003005 ABC-ATPase subunit interface; other site 768066003006 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 768066003007 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768066003008 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768066003009 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768066003010 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 768066003011 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768066003012 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768066003013 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768066003014 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 768066003015 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 768066003016 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 768066003017 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 768066003018 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768066003019 catalytic loop [active] 768066003020 iron binding site [ion binding]; other site 768066003021 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 768066003022 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 768066003023 [4Fe-4S] binding site [ion binding]; other site 768066003024 molybdopterin cofactor binding site; other site 768066003025 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 768066003026 molybdopterin cofactor binding site; other site 768066003027 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 768066003028 putative dimer interface [polypeptide binding]; other site 768066003029 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 768066003030 SLBB domain; Region: SLBB; pfam10531 768066003031 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 768066003032 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 768066003033 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 768066003034 putative dimer interface [polypeptide binding]; other site 768066003035 [2Fe-2S] cluster binding site [ion binding]; other site 768066003036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066003037 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 768066003038 PBP superfamily domain; Region: PBP_like; pfam12727 768066003039 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 768066003040 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 768066003041 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768066003042 Peptidase C26; Region: Peptidase_C26; pfam07722 768066003043 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 768066003044 catalytic triad [active] 768066003045 putative aminotransferase; Validated; Region: PRK07480 768066003046 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066003047 inhibitor-cofactor binding pocket; inhibition site 768066003048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066003049 catalytic residue [active] 768066003050 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 768066003051 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 768066003052 NAD(P) binding site [chemical binding]; other site 768066003053 catalytic residues [active] 768066003054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066003055 sequence-specific DNA binding site [nucleotide binding]; other site 768066003056 salt bridge; other site 768066003057 Cupin domain; Region: Cupin_2; pfam07883 768066003058 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 768066003059 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 768066003060 GatB domain; Region: GatB_Yqey; smart00845 768066003061 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 768066003062 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 768066003063 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 768066003064 rod shape-determining protein MreB; Provisional; Region: PRK13927 768066003065 MreB and similar proteins; Region: MreB_like; cd10225 768066003066 nucleotide binding site [chemical binding]; other site 768066003067 Mg binding site [ion binding]; other site 768066003068 putative protofilament interaction site [polypeptide binding]; other site 768066003069 RodZ interaction site [polypeptide binding]; other site 768066003070 rod shape-determining protein MreC; Provisional; Region: PRK13922 768066003071 Kinesin motor; Region: Kinesin-relat_1; pfam12711 768066003072 rod shape-determining protein MreC; Region: MreC; pfam04085 768066003073 rod shape-determining protein MreD; Region: MreD; cl01087 768066003074 Maf-like protein; Region: Maf; pfam02545 768066003075 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768066003076 active site 768066003077 dimer interface [polypeptide binding]; other site 768066003078 ribonuclease G; Provisional; Region: PRK11712 768066003079 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768066003080 homodimer interface [polypeptide binding]; other site 768066003081 oligonucleotide binding site [chemical binding]; other site 768066003082 TIGR02099 family protein; Region: TIGR02099 768066003083 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768066003084 protease TldD; Provisional; Region: tldD; PRK10735 768066003085 Protein of unknown function (DUF615); Region: DUF615; pfam04751 768066003086 peptidase PmbA; Provisional; Region: PRK11040 768066003087 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768066003088 dimerization domain swap beta strand [polypeptide binding]; other site 768066003089 regulatory protein interface [polypeptide binding]; other site 768066003090 active site 768066003091 regulatory phosphorylation site [posttranslational modification]; other site 768066003092 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 768066003093 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768066003094 active site 768066003095 phosphorylation site [posttranslational modification] 768066003096 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768066003097 30S subunit binding site; other site 768066003098 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 768066003099 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 768066003100 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 768066003101 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 768066003102 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 768066003103 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 768066003104 Walker A/P-loop; other site 768066003105 ATP binding site [chemical binding]; other site 768066003106 Q-loop/lid; other site 768066003107 ABC transporter signature motif; other site 768066003108 Walker B; other site 768066003109 D-loop; other site 768066003110 H-loop/switch region; other site 768066003111 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 768066003112 OstA-like protein; Region: OstA; pfam03968 768066003113 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 768066003114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 768066003115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066003116 active site 768066003117 motif I; other site 768066003118 motif II; other site 768066003119 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 768066003120 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768066003121 putative active site [active] 768066003122 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768066003123 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 768066003124 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 768066003125 Walker A/P-loop; other site 768066003126 ATP binding site [chemical binding]; other site 768066003127 Q-loop/lid; other site 768066003128 ABC transporter signature motif; other site 768066003129 Walker B; other site 768066003130 D-loop; other site 768066003131 H-loop/switch region; other site 768066003132 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 768066003133 Permease; Region: Permease; cl00510 768066003134 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 768066003135 mce related protein; Region: MCE; pfam02470 768066003136 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 768066003137 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768066003138 anti sigma factor interaction site; other site 768066003139 regulatory phosphorylation site [posttranslational modification]; other site 768066003140 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 768066003141 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768066003142 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768066003143 hinge; other site 768066003144 active site 768066003145 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 768066003146 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 768066003147 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768066003148 histidinol dehydrogenase; Region: hisD; TIGR00069 768066003149 NAD binding site [chemical binding]; other site 768066003150 dimerization interface [polypeptide binding]; other site 768066003151 product binding site; other site 768066003152 substrate binding site [chemical binding]; other site 768066003153 zinc binding site [ion binding]; other site 768066003154 catalytic residues [active] 768066003155 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 768066003156 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768066003157 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768066003158 protein binding site [polypeptide binding]; other site 768066003159 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768066003160 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 768066003161 Predicted ATPase [General function prediction only]; Region: COG1485 768066003162 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 768066003163 23S rRNA interface [nucleotide binding]; other site 768066003164 L3 interface [polypeptide binding]; other site 768066003165 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 768066003166 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 768066003167 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 768066003168 [2Fe-2S] cluster binding site [ion binding]; other site 768066003169 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 768066003170 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 768066003171 Qi binding site; other site 768066003172 intrachain domain interface; other site 768066003173 interchain domain interface [polypeptide binding]; other site 768066003174 heme bH binding site [chemical binding]; other site 768066003175 heme bL binding site [chemical binding]; other site 768066003176 Qo binding site; other site 768066003177 interchain domain interface [polypeptide binding]; other site 768066003178 intrachain domain interface; other site 768066003179 Qi binding site; other site 768066003180 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 768066003181 Qo binding site; other site 768066003182 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 768066003183 stringent starvation protein A; Provisional; Region: sspA; PRK09481 768066003184 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 768066003185 C-terminal domain interface [polypeptide binding]; other site 768066003186 putative GSH binding site (G-site) [chemical binding]; other site 768066003187 dimer interface [polypeptide binding]; other site 768066003188 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 768066003189 dimer interface [polypeptide binding]; other site 768066003190 N-terminal domain interface [polypeptide binding]; other site 768066003191 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 768066003192 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 768066003193 BON domain; Region: BON; pfam04972 768066003194 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768066003195 dimer interface [polypeptide binding]; other site 768066003196 active site 768066003197 hypothetical protein; Reviewed; Region: PRK12497 768066003198 LppC putative lipoprotein; Region: LppC; pfam04348 768066003199 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 768066003200 putative ligand binding site [chemical binding]; other site 768066003201 Predicted methyltransferases [General function prediction only]; Region: COG0313 768066003202 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 768066003203 putative SAM binding site [chemical binding]; other site 768066003204 putative homodimer interface [polypeptide binding]; other site 768066003205 MraW methylase family; Region: Methyltransf_5; cl17771 768066003206 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 768066003207 Cell division protein FtsL; Region: FtsL; pfam04999 768066003208 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 768066003209 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768066003210 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768066003211 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 768066003212 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768066003213 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768066003214 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768066003215 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768066003216 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 768066003217 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768066003218 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 768066003219 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 768066003220 Mg++ binding site [ion binding]; other site 768066003221 putative catalytic motif [active] 768066003222 putative substrate binding site [chemical binding]; other site 768066003223 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768066003224 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768066003225 cell division protein FtsW; Region: ftsW; TIGR02614 768066003226 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 768066003227 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 768066003228 active site 768066003229 homodimer interface [polypeptide binding]; other site 768066003230 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 768066003231 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768066003232 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768066003233 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768066003234 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 768066003235 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768066003236 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768066003237 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 768066003238 Cell division protein FtsQ; Region: FtsQ; pfam03799 768066003239 cell division protein FtsA; Region: ftsA; TIGR01174 768066003240 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768066003241 nucleotide binding site [chemical binding]; other site 768066003242 Cell division protein FtsA; Region: FtsA; pfam14450 768066003243 cell division protein FtsZ; Validated; Region: PRK09330 768066003244 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 768066003245 nucleotide binding site [chemical binding]; other site 768066003246 SulA interaction site; other site 768066003247 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 768066003248 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 768066003249 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 768066003250 Protein of unknown function (DUF721); Region: DUF721; pfam05258 768066003251 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 768066003252 DEAD/DEAH box helicase; Region: DEAD; pfam00270 768066003253 ATP binding site [chemical binding]; other site 768066003254 putative Mg++ binding site [ion binding]; other site 768066003255 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 768066003256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066003257 nucleotide binding region [chemical binding]; other site 768066003258 ATP-binding site [chemical binding]; other site 768066003259 SEC-C motif; Region: SEC-C; pfam02810 768066003260 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 768066003261 heterotetramer interface [polypeptide binding]; other site 768066003262 active site pocket [active] 768066003263 cleavage site 768066003264 hypothetical protein; Provisional; Region: PRK08999 768066003265 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 768066003266 active site 768066003267 8-oxo-dGMP binding site [chemical binding]; other site 768066003268 nudix motif; other site 768066003269 metal binding site [ion binding]; metal-binding site 768066003270 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768066003271 thiamine phosphate binding site [chemical binding]; other site 768066003272 active site 768066003273 pyrophosphate binding site [ion binding]; other site 768066003274 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 768066003275 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 768066003276 putative active site; other site 768066003277 catalytic triad [active] 768066003278 putative dimer interface [polypeptide binding]; other site 768066003279 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 768066003280 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 768066003281 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 768066003282 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768066003283 FtsX-like permease family; Region: FtsX; pfam02687 768066003284 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 768066003285 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768066003286 Walker A/P-loop; other site 768066003287 ATP binding site [chemical binding]; other site 768066003288 Q-loop/lid; other site 768066003289 ABC transporter signature motif; other site 768066003290 Walker B; other site 768066003291 D-loop; other site 768066003292 H-loop/switch region; other site 768066003293 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 768066003294 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 768066003295 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 768066003296 Competence protein; Region: Competence; pfam03772 768066003297 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 768066003298 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768066003299 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 768066003300 Walker A/P-loop; other site 768066003301 ATP binding site [chemical binding]; other site 768066003302 Q-loop/lid; other site 768066003303 ABC transporter signature motif; other site 768066003304 Walker B; other site 768066003305 D-loop; other site 768066003306 H-loop/switch region; other site 768066003307 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 768066003308 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 768066003309 Uncharacterized conserved protein [Function unknown]; Region: COG2835 768066003310 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 768066003311 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 768066003312 Ligand binding site; other site 768066003313 oligomer interface; other site 768066003314 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 768066003315 FAD binding domain; Region: FAD_binding_4; pfam01565 768066003316 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 768066003317 LysR family transcriptional regulator; Provisional; Region: PRK14997 768066003318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066003319 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 768066003320 putative effector binding pocket; other site 768066003321 putative dimerization interface [polypeptide binding]; other site 768066003322 Pirin-related protein [General function prediction only]; Region: COG1741 768066003323 Pirin; Region: Pirin; pfam02678 768066003324 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768066003325 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768066003326 Isochorismatase family; Region: Isochorismatase; pfam00857 768066003327 catalytic triad [active] 768066003328 dimer interface [polypeptide binding]; other site 768066003329 conserved cis-peptide bond; other site 768066003330 Pirin-related protein [General function prediction only]; Region: COG1741 768066003331 Pirin; Region: Pirin; pfam02678 768066003332 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768066003333 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 768066003334 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768066003335 homodimer interface [polypeptide binding]; other site 768066003336 oligonucleotide binding site [chemical binding]; other site 768066003337 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 768066003338 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768066003339 RNA binding surface [nucleotide binding]; other site 768066003340 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768066003341 active site 768066003342 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 768066003343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066003344 active site 768066003345 motif I; other site 768066003346 motif II; other site 768066003347 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768066003348 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 768066003349 tandem repeat interface [polypeptide binding]; other site 768066003350 oligomer interface [polypeptide binding]; other site 768066003351 active site residues [active] 768066003352 Maf-like protein; Region: Maf; pfam02545 768066003353 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768066003354 active site 768066003355 dimer interface [polypeptide binding]; other site 768066003356 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 768066003357 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 768066003358 putative phosphate acyltransferase; Provisional; Region: PRK05331 768066003359 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 768066003360 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768066003361 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768066003362 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768066003363 NAD(P) binding site [chemical binding]; other site 768066003364 homotetramer interface [polypeptide binding]; other site 768066003365 homodimer interface [polypeptide binding]; other site 768066003366 active site 768066003367 acyl carrier protein; Provisional; Region: acpP; PRK00982 768066003368 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 768066003369 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768066003370 dimer interface [polypeptide binding]; other site 768066003371 active site 768066003372 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768066003373 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 768066003374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066003375 catalytic residue [active] 768066003376 YceG-like family; Region: YceG; pfam02618 768066003377 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 768066003378 dimerization interface [polypeptide binding]; other site 768066003379 thymidylate kinase; Validated; Region: tmk; PRK00698 768066003380 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768066003381 TMP-binding site; other site 768066003382 ATP-binding site [chemical binding]; other site 768066003383 DNA polymerase III subunit delta'; Validated; Region: PRK05707 768066003384 DNA polymerase III subunit delta'; Validated; Region: PRK08485 768066003385 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 768066003386 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768066003387 active site 768066003388 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 768066003389 Family description; Region: UvrD_C_2; pfam13538 768066003390 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 768066003391 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768066003392 active site residue [active] 768066003393 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768066003394 active site residue [active] 768066003395 MltA-interacting protein MipA; Region: MipA; cl01504 768066003396 WGR domain; Region: WGR; cl01581 768066003397 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 768066003398 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 768066003399 ligand binding site [chemical binding]; other site 768066003400 NAD binding site [chemical binding]; other site 768066003401 catalytic site [active] 768066003402 homodimer interface [polypeptide binding]; other site 768066003403 heat shock protein HtpX; Provisional; Region: PRK05457 768066003404 aminotransferase AlaT; Validated; Region: PRK09265 768066003405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066003406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066003407 homodimer interface [polypeptide binding]; other site 768066003408 catalytic residue [active] 768066003409 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 768066003410 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 768066003411 GTP/Mg2+ binding site [chemical binding]; other site 768066003412 G4 box; other site 768066003413 G5 box; other site 768066003414 G1 box; other site 768066003415 Switch I region; other site 768066003416 G2 box; other site 768066003417 G3 box; other site 768066003418 Switch II region; other site 768066003419 methionine sulfoxide reductase B; Provisional; Region: PRK00222 768066003420 SelR domain; Region: SelR; pfam01641 768066003421 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768066003422 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768066003423 Walker A/P-loop; other site 768066003424 ATP binding site [chemical binding]; other site 768066003425 Q-loop/lid; other site 768066003426 ABC transporter signature motif; other site 768066003427 Walker B; other site 768066003428 D-loop; other site 768066003429 H-loop/switch region; other site 768066003430 inner membrane transport permease; Provisional; Region: PRK15066 768066003431 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768066003432 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 768066003433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 768066003434 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 768066003435 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 768066003436 putative FMN binding site [chemical binding]; other site 768066003437 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 768066003438 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 768066003439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768066003440 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768066003441 ABC transporter; Region: ABC_tran_2; pfam12848 768066003442 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768066003443 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 768066003444 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 768066003445 active site 768066003446 DNA binding site [nucleotide binding] 768066003447 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768066003448 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768066003449 Catalytic site [active] 768066003450 glutamate carboxypeptidase; Reviewed; Region: PRK06133 768066003451 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 768066003452 metal binding site [ion binding]; metal-binding site 768066003453 dimer interface [polypeptide binding]; other site 768066003454 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 768066003455 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 768066003456 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 768066003457 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768066003458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066003459 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 768066003460 DNA-binding site [nucleotide binding]; DNA binding site 768066003461 FCD domain; Region: FCD; pfam07729 768066003462 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 768066003463 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768066003464 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768066003465 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 768066003466 putative GTP cyclohydrolase; Provisional; Region: PRK13674 768066003467 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066003468 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 768066003469 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768066003470 DctM-like transporters; Region: DctM; pfam06808 768066003471 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066003472 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066003473 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066003474 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768066003475 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768066003476 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066003477 Predicted flavoproteins [General function prediction only]; Region: COG2081 768066003478 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 768066003479 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 768066003480 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768066003481 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768066003482 P-loop; other site 768066003483 Magnesium ion binding site [ion binding]; other site 768066003484 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768066003485 YqjK-like protein; Region: YqjK; pfam13997 768066003486 Predicted membrane protein [Function unknown]; Region: COG5393 768066003487 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 768066003488 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 768066003489 dimerization interface [polypeptide binding]; other site 768066003490 substrate binding site [chemical binding]; other site 768066003491 active site 768066003492 calcium binding site [ion binding]; other site 768066003493 hypothetical protein; Provisional; Region: PRK11281 768066003494 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 768066003495 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768066003496 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 768066003497 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768066003498 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066003499 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 768066003500 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 768066003501 putative active site [active] 768066003502 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768066003503 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 768066003504 Walker A/P-loop; other site 768066003505 ATP binding site [chemical binding]; other site 768066003506 Q-loop/lid; other site 768066003507 ABC transporter signature motif; other site 768066003508 Walker B; other site 768066003509 D-loop; other site 768066003510 H-loop/switch region; other site 768066003511 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 768066003512 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768066003513 RNA binding surface [nucleotide binding]; other site 768066003514 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 768066003515 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768066003516 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 768066003517 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 768066003518 Protein of unknown function (DUF533); Region: DUF533; pfam04391 768066003519 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 768066003520 putative metal binding site [ion binding]; other site 768066003521 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 768066003522 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 768066003523 active site 768066003524 Zn binding site [ion binding]; other site 768066003525 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 768066003526 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768066003527 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768066003528 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 768066003529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066003530 Walker A motif; other site 768066003531 ATP binding site [chemical binding]; other site 768066003532 Walker B motif; other site 768066003533 arginine finger; other site 768066003534 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 768066003535 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 768066003536 hypothetical protein; Validated; Region: PRK00153 768066003537 recombination protein RecR; Reviewed; Region: recR; PRK00076 768066003538 RecR protein; Region: RecR; pfam02132 768066003539 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 768066003540 putative active site [active] 768066003541 putative metal-binding site [ion binding]; other site 768066003542 tetramer interface [polypeptide binding]; other site 768066003543 ribonuclease D; Region: rnd; TIGR01388 768066003544 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 768066003545 catalytic site [active] 768066003546 putative active site [active] 768066003547 putative substrate binding site [chemical binding]; other site 768066003548 HRDC domain; Region: HRDC; pfam00570 768066003549 YcgL domain; Region: YcgL; pfam05166 768066003550 hypothetical protein; Provisional; Region: PRK05170 768066003551 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768066003552 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768066003553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066003554 putative PBP binding loops; other site 768066003555 ABC-ATPase subunit interface; other site 768066003556 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 768066003557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066003558 Walker A/P-loop; other site 768066003559 ATP binding site [chemical binding]; other site 768066003560 Q-loop/lid; other site 768066003561 ABC transporter signature motif; other site 768066003562 Walker B; other site 768066003563 D-loop; other site 768066003564 H-loop/switch region; other site 768066003565 TOBE domain; Region: TOBE; cl01440 768066003566 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 768066003567 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768066003568 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 768066003569 metal ion-dependent adhesion site (MIDAS); other site 768066003570 TIGR03503 family protein; Region: TIGR03503 768066003571 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 768066003572 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 768066003573 Phage-related protein, tail component [Function unknown]; Region: COG4733 768066003574 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768066003575 NlpC/P60 family; Region: NLPC_P60; cl17555 768066003576 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 768066003577 Chorismate mutase type II; Region: CM_2; cl00693 768066003578 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 768066003579 Phage-related minor tail protein [Function unknown]; Region: COG5281 768066003580 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 768066003581 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 768066003582 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 768066003583 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 768066003584 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 768066003585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 768066003586 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 768066003587 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 768066003588 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 768066003589 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 768066003590 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 768066003591 Phage terminase large subunit; Region: Terminase_3; cl12054 768066003592 Terminase small subunit; Region: Terminase_2; pfam03592 768066003593 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 768066003594 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 768066003595 Protein of unknown function (DUF968); Region: DUF968; pfam06147 768066003596 hypothetical protein; Provisional; Region: PRK09741 768066003597 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 768066003598 DNA binding residues [nucleotide binding] 768066003599 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 768066003600 non-specific DNA interactions [nucleotide binding]; other site 768066003601 DNA binding site [nucleotide binding] 768066003602 sequence specific DNA binding site [nucleotide binding]; other site 768066003603 putative cAMP binding site [chemical binding]; other site 768066003604 Prophage antirepressor [Transcription]; Region: COG3617 768066003605 BRO family, N-terminal domain; Region: Bro-N; pfam02498 768066003606 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 768066003607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066003608 non-specific DNA binding site [nucleotide binding]; other site 768066003609 salt bridge; other site 768066003610 Predicted transcriptional regulator [Transcription]; Region: COG2932 768066003611 sequence-specific DNA binding site [nucleotide binding]; other site 768066003612 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768066003613 Catalytic site [active] 768066003614 Putative exonuclease, RdgC; Region: RdgC; pfam04381 768066003615 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768066003616 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768066003617 dimer interface [polypeptide binding]; other site 768066003618 ssDNA binding site [nucleotide binding]; other site 768066003619 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768066003620 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768066003621 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768066003622 cofactor binding site; other site 768066003623 DNA binding site [nucleotide binding] 768066003624 substrate interaction site [chemical binding]; other site 768066003625 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768066003626 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768066003627 HD domain; Region: HD_4; pfam13328 768066003628 HNH endonuclease; Region: HNH_3; pfam13392 768066003629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768066003630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 768066003631 DNA binding residues [nucleotide binding] 768066003632 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768066003633 active site 768066003634 DNA binding site [nucleotide binding] 768066003635 Int/Topo IB signature motif; other site 768066003636 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 768066003637 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 768066003638 putative active site [active] 768066003639 putative dimer interface [polypeptide binding]; other site 768066003640 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 768066003641 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 768066003642 acyl-activating enzyme (AAE) consensus motif; other site 768066003643 putative AMP binding site [chemical binding]; other site 768066003644 putative active site [active] 768066003645 putative CoA binding site [chemical binding]; other site 768066003646 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 768066003647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768066003648 ATP binding site [chemical binding]; other site 768066003649 putative Mg++ binding site [ion binding]; other site 768066003650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066003651 nucleotide binding region [chemical binding]; other site 768066003652 ATP-binding site [chemical binding]; other site 768066003653 Helicase associated domain (HA2); Region: HA2; pfam04408 768066003654 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 768066003655 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 768066003656 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 768066003657 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768066003658 dimer interface [polypeptide binding]; other site 768066003659 active site 768066003660 CoA binding pocket [chemical binding]; other site 768066003661 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 768066003662 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 768066003663 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768066003664 anti sigma factor interaction site; other site 768066003665 regulatory phosphorylation site [posttranslational modification]; other site 768066003666 transaldolase-like protein; Provisional; Region: PTZ00411 768066003667 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768066003668 active site 768066003669 dimer interface [polypeptide binding]; other site 768066003670 catalytic residue [active] 768066003671 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 768066003672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066003673 PBP superfamily domain; Region: PBP_like_2; cl17296 768066003674 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 768066003675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066003676 dimer interface [polypeptide binding]; other site 768066003677 conserved gate region; other site 768066003678 putative PBP binding loops; other site 768066003679 ABC-ATPase subunit interface; other site 768066003680 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 768066003681 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 768066003682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066003683 putative PBP binding loops; other site 768066003684 ABC-ATPase subunit interface; other site 768066003685 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 768066003686 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768066003687 Walker A/P-loop; other site 768066003688 ATP binding site [chemical binding]; other site 768066003689 Q-loop/lid; other site 768066003690 ABC transporter signature motif; other site 768066003691 Walker B; other site 768066003692 D-loop; other site 768066003693 H-loop/switch region; other site 768066003694 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 768066003695 Low molecular weight phosphatase family; Region: LMWPc; cd00115 768066003696 active site 768066003697 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 768066003698 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768066003699 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768066003700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768066003701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768066003702 dimerization interface [polypeptide binding]; other site 768066003703 putative DNA binding site [nucleotide binding]; other site 768066003704 putative Zn2+ binding site [ion binding]; other site 768066003705 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768066003706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066003707 dimer interface [polypeptide binding]; other site 768066003708 conserved gate region; other site 768066003709 putative PBP binding loops; other site 768066003710 ABC-ATPase subunit interface; other site 768066003711 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768066003712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066003713 dimer interface [polypeptide binding]; other site 768066003714 conserved gate region; other site 768066003715 ABC-ATPase subunit interface; other site 768066003716 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 768066003717 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 768066003718 Walker A/P-loop; other site 768066003719 ATP binding site [chemical binding]; other site 768066003720 Q-loop/lid; other site 768066003721 ABC transporter signature motif; other site 768066003722 Walker B; other site 768066003723 D-loop; other site 768066003724 H-loop/switch region; other site 768066003725 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 768066003726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066003727 Walker A/P-loop; other site 768066003728 ATP binding site [chemical binding]; other site 768066003729 ABC transporter; Region: ABC_tran; pfam00005 768066003730 Q-loop/lid; other site 768066003731 ABC transporter signature motif; other site 768066003732 Walker B; other site 768066003733 D-loop; other site 768066003734 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 768066003735 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 768066003736 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768066003737 dimer interface [polypeptide binding]; other site 768066003738 active site 768066003739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066003740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066003741 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 768066003742 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768066003743 acyl-activating enzyme (AAE) consensus motif; other site 768066003744 AMP binding site [chemical binding]; other site 768066003745 active site 768066003746 CoA binding site [chemical binding]; other site 768066003747 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 768066003748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066003749 NAD(P) binding site [chemical binding]; other site 768066003750 active site 768066003751 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 768066003752 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 768066003753 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768066003754 active site 768066003755 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 768066003756 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 768066003757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066003758 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 768066003759 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768066003760 catalytic loop [active] 768066003761 iron binding site [ion binding]; other site 768066003762 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768066003763 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768066003764 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 768066003765 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768066003766 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768066003767 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768066003768 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768066003769 classical (c) SDRs; Region: SDR_c; cd05233 768066003770 NAD(P) binding site [chemical binding]; other site 768066003771 active site 768066003772 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768066003773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 768066003774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768066003775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066003776 Coenzyme A binding pocket [chemical binding]; other site 768066003777 Uncharacterized conserved protein [Function unknown]; Region: COG1683 768066003778 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 768066003779 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066003780 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 768066003781 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768066003782 putative catalytic residue [active] 768066003783 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904 768066003784 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066003785 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 768066003786 inhibitor-cofactor binding pocket; inhibition site 768066003787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066003788 catalytic residue [active] 768066003789 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768066003790 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768066003791 putative DNA binding site [nucleotide binding]; other site 768066003792 putative Zn2+ binding site [ion binding]; other site 768066003793 AsnC family; Region: AsnC_trans_reg; pfam01037 768066003794 Nucleoside recognition; Region: Gate; pfam07670 768066003795 RibD C-terminal domain; Region: RibD_C; cl17279 768066003796 Anti-sigma-K factor rskA; Region: RskA; pfam10099 768066003797 RNA polymerase sigma factor; Provisional; Region: PRK12514 768066003798 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768066003799 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768066003800 DNA binding residues [nucleotide binding] 768066003801 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 768066003802 putative active site [active] 768066003803 putative catalytic site [active] 768066003804 putative DNA binding site [nucleotide binding]; other site 768066003805 putative phosphate binding site [ion binding]; other site 768066003806 putative Mg binding site IVa [ion binding]; other site 768066003807 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 768066003808 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 768066003809 AAA domain; Region: AAA_26; pfam13500 768066003810 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 768066003811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066003812 S-adenosylmethionine binding site [chemical binding]; other site 768066003813 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 768066003814 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 768066003815 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 768066003816 substrate-cofactor binding pocket; other site 768066003817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066003818 catalytic residue [active] 768066003819 biotin synthase; Provisional; Region: PRK15108 768066003820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066003821 FeS/SAM binding site; other site 768066003822 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 768066003823 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 768066003824 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768066003825 active site 768066003826 serine/threonine protein kinase; Provisional; Region: PRK11768 768066003827 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 768066003828 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 768066003829 homodecamer interface [polypeptide binding]; other site 768066003830 GTP cyclohydrolase I; Provisional; Region: PLN03044 768066003831 active site 768066003832 putative catalytic site residues [active] 768066003833 zinc binding site [ion binding]; other site 768066003834 GTP-CH-I/GFRP interaction surface; other site 768066003835 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 768066003836 active site 768066003837 succinic semialdehyde dehydrogenase; Region: PLN02278 768066003838 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768066003839 tetramerization interface [polypeptide binding]; other site 768066003840 NAD(P) binding site [chemical binding]; other site 768066003841 catalytic residues [active] 768066003842 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 768066003843 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 768066003844 purine monophosphate binding site [chemical binding]; other site 768066003845 dimer interface [polypeptide binding]; other site 768066003846 putative catalytic residues [active] 768066003847 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 768066003848 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 768066003849 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768066003850 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 768066003851 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768066003852 FMN binding site [chemical binding]; other site 768066003853 active site 768066003854 catalytic residues [active] 768066003855 substrate binding site [chemical binding]; other site 768066003856 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 768066003857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066003858 S-adenosylmethionine binding site [chemical binding]; other site 768066003859 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 768066003860 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768066003861 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768066003862 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768066003863 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 768066003864 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768066003865 carboxyltransferase (CT) interaction site; other site 768066003866 biotinylation site [posttranslational modification]; other site 768066003867 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 768066003868 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 768066003869 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 768066003870 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 768066003871 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 768066003872 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 768066003873 dimer interface [polypeptide binding]; other site 768066003874 substrate binding site [chemical binding]; other site 768066003875 metal binding sites [ion binding]; metal-binding site 768066003876 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 768066003877 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 768066003878 Catalytic domain of Protein Kinases; Region: PKc; cd00180 768066003879 active site 768066003880 ATP binding site [chemical binding]; other site 768066003881 substrate binding site [chemical binding]; other site 768066003882 activation loop (A-loop); other site 768066003883 6-phosphofructokinase; Provisional; Region: PRK14072 768066003884 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768066003885 active site 768066003886 ADP/pyrophosphate binding site [chemical binding]; other site 768066003887 dimerization interface [polypeptide binding]; other site 768066003888 allosteric effector site; other site 768066003889 fructose-1,6-bisphosphate binding site; other site 768066003890 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 768066003891 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768066003892 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768066003893 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768066003894 aromatic acid decarboxylase; Validated; Region: PRK05920 768066003895 Flavoprotein; Region: Flavoprotein; pfam02441 768066003896 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768066003897 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768066003898 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768066003899 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 768066003900 active site 768066003901 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768066003902 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768066003903 metal binding site [ion binding]; metal-binding site 768066003904 active site 768066003905 I-site; other site 768066003906 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 768066003907 putative catalytic cysteine [active] 768066003908 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 768066003909 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 768066003910 active site 768066003911 (T/H)XGH motif; other site 768066003912 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 768066003913 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 768066003914 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 768066003915 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768066003916 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768066003917 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 768066003918 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768066003919 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768066003920 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768066003921 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 768066003922 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 768066003923 Sporulation related domain; Region: SPOR; pfam05036 768066003924 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 768066003925 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768066003926 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 768066003927 Protein of unknown function (DUF493); Region: DUF493; pfam04359 768066003928 lipoate-protein ligase B; Provisional; Region: PRK14342 768066003929 lipoyl synthase; Provisional; Region: PRK05481 768066003930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066003931 FeS/SAM binding site; other site 768066003932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066003933 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 768066003934 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 768066003935 putative dimerization interface [polypeptide binding]; other site 768066003936 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768066003937 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 768066003938 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 768066003939 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 768066003940 active site 768066003941 interdomain interaction site; other site 768066003942 putative metal-binding site [ion binding]; other site 768066003943 nucleotide binding site [chemical binding]; other site 768066003944 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768066003945 domain I; other site 768066003946 DNA binding groove [nucleotide binding] 768066003947 phosphate binding site [ion binding]; other site 768066003948 domain II; other site 768066003949 domain III; other site 768066003950 nucleotide binding site [chemical binding]; other site 768066003951 catalytic site [active] 768066003952 domain IV; other site 768066003953 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768066003954 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768066003955 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768066003956 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 768066003957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 768066003958 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768066003959 L,D-transpeptidase; Provisional; Region: PRK10260 768066003960 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768066003961 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 768066003962 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 768066003963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768066003964 ATP binding site [chemical binding]; other site 768066003965 putative Mg++ binding site [ion binding]; other site 768066003966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066003967 nucleotide binding region [chemical binding]; other site 768066003968 ATP-binding site [chemical binding]; other site 768066003969 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 768066003970 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 768066003971 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768066003972 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768066003973 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 768066003974 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 768066003975 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 768066003976 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 768066003977 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 768066003978 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 768066003979 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 768066003980 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 768066003981 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768066003982 catalytic loop [active] 768066003983 iron binding site [ion binding]; other site 768066003984 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 768066003985 FAD binding pocket [chemical binding]; other site 768066003986 FAD binding motif [chemical binding]; other site 768066003987 phosphate binding motif [ion binding]; other site 768066003988 beta-alpha-beta structure motif; other site 768066003989 NAD binding pocket [chemical binding]; other site 768066003990 Protein of unknown function (DUF539); Region: DUF539; cl01129 768066003991 Protein of unknown function, DUF488; Region: DUF488; cl01246 768066003992 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 768066003993 putative active site [active] 768066003994 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 768066003995 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 768066003996 Lipopolysaccharide-assembly; Region: LptE; cl01125 768066003997 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 768066003998 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768066003999 HIGH motif; other site 768066004000 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768066004001 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768066004002 active site 768066004003 KMSKS motif; other site 768066004004 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 768066004005 tRNA binding surface [nucleotide binding]; other site 768066004006 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 768066004007 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 768066004008 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066004009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066004010 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768066004011 dimerization interface [polypeptide binding]; other site 768066004012 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 768066004013 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 768066004014 substrate binding site [chemical binding]; other site 768066004015 ligand binding site [chemical binding]; other site 768066004016 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 768066004017 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 768066004018 substrate binding site [chemical binding]; other site 768066004019 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 768066004020 tartrate dehydrogenase; Region: TTC; TIGR02089 768066004021 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 768066004022 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768066004023 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768066004024 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 768066004025 dimerization interface 3.5A [polypeptide binding]; other site 768066004026 active site 768066004027 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 768066004028 active site 768066004029 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 768066004030 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 768066004031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066004032 catalytic residue [active] 768066004033 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 768066004034 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 768066004035 substrate binding site [chemical binding]; other site 768066004036 active site 768066004037 catalytic residues [active] 768066004038 heterodimer interface [polypeptide binding]; other site 768066004039 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 768066004040 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 768066004041 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 768066004042 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768066004043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 768066004044 Sporulation related domain; Region: SPOR; pfam05036 768066004045 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 768066004046 Colicin V production protein; Region: Colicin_V; pfam02674 768066004047 amidophosphoribosyltransferase; Provisional; Region: PRK09246 768066004048 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 768066004049 active site 768066004050 tetramer interface [polypeptide binding]; other site 768066004051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768066004052 active site 768066004053 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 768066004054 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768066004055 homodimer interface [polypeptide binding]; other site 768066004056 substrate-cofactor binding pocket; other site 768066004057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066004058 catalytic residue [active] 768066004059 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 768066004060 YceI-like domain; Region: YceI; cl01001 768066004061 Biofilm formation and stress response factor; Region: BsmA; cl01794 768066004062 PAS domain S-box; Region: sensory_box; TIGR00229 768066004063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768066004064 putative active site [active] 768066004065 heme pocket [chemical binding]; other site 768066004066 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768066004067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768066004068 metal binding site [ion binding]; metal-binding site 768066004069 active site 768066004070 I-site; other site 768066004071 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768066004072 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768066004073 putative efflux protein, MATE family; Region: matE; TIGR00797 768066004074 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 768066004075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768066004076 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768066004077 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 768066004078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066004079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066004080 homodimer interface [polypeptide binding]; other site 768066004081 catalytic residue [active] 768066004082 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 768066004083 aromatic arch; other site 768066004084 DCoH dimer interaction site [polypeptide binding]; other site 768066004085 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 768066004086 DCoH tetramer interaction site [polypeptide binding]; other site 768066004087 substrate binding site [chemical binding]; other site 768066004088 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 768066004089 cofactor binding site; other site 768066004090 metal binding site [ion binding]; metal-binding site 768066004091 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 768066004092 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768066004093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768066004094 putative active site [active] 768066004095 heme pocket [chemical binding]; other site 768066004096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066004097 Walker A motif; other site 768066004098 ATP binding site [chemical binding]; other site 768066004099 Walker B motif; other site 768066004100 arginine finger; other site 768066004101 Helix-turn-helix domain; Region: HTH_38; pfam13936 768066004102 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768066004103 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768066004104 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 768066004105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066004106 S-adenosylmethionine binding site [chemical binding]; other site 768066004107 Domain of unknown function DUF77; Region: DUF77; pfam01910 768066004108 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 768066004109 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 768066004110 dimer interface [polypeptide binding]; other site 768066004111 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 768066004112 active site 768066004113 Fe binding site [ion binding]; other site 768066004114 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 768066004115 Na2 binding site [ion binding]; other site 768066004116 putative substrate binding site 1 [chemical binding]; other site 768066004117 Na binding site 1 [ion binding]; other site 768066004118 putative substrate binding site 2 [chemical binding]; other site 768066004119 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768066004120 active site 768066004121 SAM binding site [chemical binding]; other site 768066004122 homodimer interface [polypeptide binding]; other site 768066004123 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 768066004124 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 768066004125 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 768066004126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066004127 dimer interface [polypeptide binding]; other site 768066004128 phosphorylation site [posttranslational modification] 768066004129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066004130 ATP binding site [chemical binding]; other site 768066004131 Mg2+ binding site [ion binding]; other site 768066004132 G-X-G motif; other site 768066004133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768066004134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066004135 active site 768066004136 phosphorylation site [posttranslational modification] 768066004137 intermolecular recognition site; other site 768066004138 dimerization interface [polypeptide binding]; other site 768066004139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066004140 DNA binding site [nucleotide binding] 768066004141 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 768066004142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768066004143 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 768066004144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 768066004145 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 768066004146 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 768066004147 putative ligand binding site [chemical binding]; other site 768066004148 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768066004149 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768066004150 TM-ABC transporter signature motif; other site 768066004151 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768066004152 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768066004153 TM-ABC transporter signature motif; other site 768066004154 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 768066004155 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768066004156 Walker A/P-loop; other site 768066004157 ATP binding site [chemical binding]; other site 768066004158 Q-loop/lid; other site 768066004159 ABC transporter signature motif; other site 768066004160 Walker B; other site 768066004161 D-loop; other site 768066004162 H-loop/switch region; other site 768066004163 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 768066004164 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768066004165 Walker A/P-loop; other site 768066004166 ATP binding site [chemical binding]; other site 768066004167 Q-loop/lid; other site 768066004168 ABC transporter signature motif; other site 768066004169 Walker B; other site 768066004170 D-loop; other site 768066004171 H-loop/switch region; other site 768066004172 UreD urease accessory protein; Region: UreD; pfam01774 768066004173 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 768066004174 alpha-gamma subunit interface [polypeptide binding]; other site 768066004175 beta-gamma subunit interface [polypeptide binding]; other site 768066004176 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 768066004177 gamma-beta subunit interface [polypeptide binding]; other site 768066004178 alpha-beta subunit interface [polypeptide binding]; other site 768066004179 urease subunit alpha; Reviewed; Region: ureC; PRK13207 768066004180 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 768066004181 subunit interactions [polypeptide binding]; other site 768066004182 active site 768066004183 flap region; other site 768066004184 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 768066004185 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 768066004186 dimer interface [polypeptide binding]; other site 768066004187 catalytic residues [active] 768066004188 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 768066004189 UreF; Region: UreF; pfam01730 768066004190 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768066004191 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 768066004192 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 768066004193 putative active site [active] 768066004194 catalytic site [active] 768066004195 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 768066004196 PLD-like domain; Region: PLDc_2; pfam13091 768066004197 putative active site [active] 768066004198 putative catalytic site [active] 768066004199 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 768066004200 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 768066004201 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 768066004202 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768066004203 trimer interface [polypeptide binding]; other site 768066004204 active site 768066004205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 768066004206 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 768066004207 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 768066004208 active site 768066004209 catalytic triad [active] 768066004210 oxyanion hole [active] 768066004211 Autotransporter beta-domain; Region: Autotransporter; pfam03797 768066004212 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 768066004213 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 768066004214 active site 768066004215 substrate binding site [chemical binding]; other site 768066004216 cosubstrate binding site; other site 768066004217 catalytic site [active] 768066004218 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 768066004219 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 768066004220 dimerization interface [polypeptide binding]; other site 768066004221 putative ATP binding site [chemical binding]; other site 768066004222 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768066004223 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768066004224 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 768066004225 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 768066004226 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 768066004227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768066004228 substrate binding pocket [chemical binding]; other site 768066004229 membrane-bound complex binding site; other site 768066004230 hinge residues; other site 768066004231 C2 domain; Region: C2; cl14603 768066004232 Phasin protein; Region: Phasin_2; cl11491 768066004233 fumarate hydratase; Reviewed; Region: fumC; PRK00485 768066004234 Class II fumarases; Region: Fumarase_classII; cd01362 768066004235 active site 768066004236 tetramer interface [polypeptide binding]; other site 768066004237 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768066004238 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768066004239 DNA topoisomerase III; Provisional; Region: PRK07726 768066004240 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768066004241 active site 768066004242 putative interdomain interaction site [polypeptide binding]; other site 768066004243 putative metal-binding site [ion binding]; other site 768066004244 putative nucleotide binding site [chemical binding]; other site 768066004245 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768066004246 domain I; other site 768066004247 DNA binding groove [nucleotide binding] 768066004248 phosphate binding site [ion binding]; other site 768066004249 domain II; other site 768066004250 domain III; other site 768066004251 nucleotide binding site [chemical binding]; other site 768066004252 catalytic site [active] 768066004253 domain IV; other site 768066004254 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 768066004255 ABC1 family; Region: ABC1; cl17513 768066004256 SEC-C motif; Region: SEC-C; pfam02810 768066004257 muropeptide transporter; Reviewed; Region: ampG; PRK11902 768066004258 muropeptide transporter; Validated; Region: ampG; cl17669 768066004259 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 768066004260 transcriptional activator RfaH; Region: RfaH; TIGR01955 768066004261 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 768066004262 heterodimer interface [polypeptide binding]; other site 768066004263 homodimer interface [polypeptide binding]; other site 768066004264 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 768066004265 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768066004266 prolyl-tRNA synthetase; Provisional; Region: PRK09194 768066004267 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 768066004268 dimer interface [polypeptide binding]; other site 768066004269 motif 1; other site 768066004270 active site 768066004271 motif 2; other site 768066004272 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 768066004273 putative deacylase active site [active] 768066004274 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768066004275 active site 768066004276 motif 3; other site 768066004277 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 768066004278 anticodon binding site; other site 768066004279 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768066004280 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 768066004281 putative active site [active] 768066004282 catalytic triad [active] 768066004283 putative dimer interface [polypeptide binding]; other site 768066004284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066004285 Coenzyme A binding pocket [chemical binding]; other site 768066004286 benzoate transporter; Region: benE; TIGR00843 768066004287 Benzoate membrane transport protein; Region: BenE; pfam03594 768066004288 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 768066004289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066004290 non-specific DNA binding site [nucleotide binding]; other site 768066004291 salt bridge; other site 768066004292 sequence-specific DNA binding site [nucleotide binding]; other site 768066004293 Cupin domain; Region: Cupin_2; pfam07883 768066004294 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768066004295 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768066004296 amidase catalytic site [active] 768066004297 Zn binding residues [ion binding]; other site 768066004298 substrate binding site [chemical binding]; other site 768066004299 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 768066004300 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 768066004301 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 768066004302 metal binding site [ion binding]; metal-binding site 768066004303 nucleotidyl binding site; other site 768066004304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 768066004305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066004306 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768066004307 Walker A motif; other site 768066004308 ATP binding site [chemical binding]; other site 768066004309 Walker B motif; other site 768066004310 arginine finger; other site 768066004311 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 768066004312 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768066004313 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768066004314 Nucleoid-associated protein [General function prediction only]; Region: COG3081 768066004315 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 768066004316 ABC-2 type transporter; Region: ABC2_membrane; cl17235 768066004317 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768066004318 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768066004319 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768066004320 Walker A/P-loop; other site 768066004321 ATP binding site [chemical binding]; other site 768066004322 Q-loop/lid; other site 768066004323 ABC transporter signature motif; other site 768066004324 Walker B; other site 768066004325 D-loop; other site 768066004326 H-loop/switch region; other site 768066004327 Uncharacterized conserved protein [Function unknown]; Region: COG3791 768066004328 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768066004329 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 768066004330 Helix-turn-helix domain; Region: HTH_18; pfam12833 768066004331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066004332 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 768066004333 Uncharacterized conserved protein [Function unknown]; Region: COG2128 768066004334 Protein of unknown function, DUF399; Region: DUF399; pfam04187 768066004335 Methyltransferase domain; Region: Methyltransf_32; pfam13679 768066004336 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 768066004337 putative deacylase active site [active] 768066004338 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 768066004339 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768066004340 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768066004341 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768066004342 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 768066004343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066004344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066004345 homodimer interface [polypeptide binding]; other site 768066004346 catalytic residue [active] 768066004347 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768066004348 FAD binding domain; Region: FAD_binding_4; pfam01565 768066004349 Predicted ATPase [General function prediction only]; Region: COG3911 768066004350 AAA domain; Region: AAA_28; pfam13521 768066004351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066004352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066004353 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768066004354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066004355 NAD(P) binding site [chemical binding]; other site 768066004356 active site 768066004357 SnoaL-like domain; Region: SnoaL_2; pfam12680 768066004358 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 768066004359 putative metal binding site [ion binding]; other site 768066004360 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768066004361 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768066004362 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768066004363 dihydroorotase; Provisional; Region: PRK05451 768066004364 active site 768066004365 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 768066004366 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 768066004367 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 768066004368 S-ribosylhomocysteinase; Provisional; Region: PRK02260 768066004369 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 768066004370 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 768066004371 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 768066004372 homodimer interface [polypeptide binding]; other site 768066004373 NADP binding site [chemical binding]; other site 768066004374 substrate binding site [chemical binding]; other site 768066004375 trigger factor; Provisional; Region: tig; PRK01490 768066004376 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768066004377 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 768066004378 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 768066004379 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768066004380 oligomer interface [polypeptide binding]; other site 768066004381 active site residues [active] 768066004382 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 768066004383 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 768066004384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066004385 Walker A motif; other site 768066004386 ATP binding site [chemical binding]; other site 768066004387 Walker B motif; other site 768066004388 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768066004389 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 768066004390 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768066004391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066004392 Walker A motif; other site 768066004393 ATP binding site [chemical binding]; other site 768066004394 Walker B motif; other site 768066004395 arginine finger; other site 768066004396 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768066004397 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768066004398 IHF dimer interface [polypeptide binding]; other site 768066004399 IHF - DNA interface [nucleotide binding]; other site 768066004400 periplasmic folding chaperone; Provisional; Region: PRK10788 768066004401 SurA N-terminal domain; Region: SurA_N_3; cl07813 768066004402 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768066004403 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 768066004404 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 768066004405 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 768066004406 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 768066004407 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 768066004408 FAD binding site [chemical binding]; other site 768066004409 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 768066004410 putative active site [active] 768066004411 putative metal binding site [ion binding]; other site 768066004412 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 768066004413 substrate binding site [chemical binding]; other site 768066004414 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 768066004415 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768066004416 active site 768066004417 HIGH motif; other site 768066004418 nucleotide binding site [chemical binding]; other site 768066004419 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 768066004420 KMSKS motif; other site 768066004421 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 768066004422 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 768066004423 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768066004424 active site 768066004425 HIGH motif; other site 768066004426 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768066004427 KMSKS motif; other site 768066004428 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 768066004429 tRNA binding surface [nucleotide binding]; other site 768066004430 anticodon binding site; other site 768066004431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066004432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066004433 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 768066004434 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 768066004435 Amidinotransferase; Region: Amidinotransf; pfam02274 768066004436 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768066004437 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768066004438 Walker A/P-loop; other site 768066004439 ATP binding site [chemical binding]; other site 768066004440 Q-loop/lid; other site 768066004441 ABC transporter signature motif; other site 768066004442 Walker B; other site 768066004443 D-loop; other site 768066004444 H-loop/switch region; other site 768066004445 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768066004446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768066004447 substrate binding pocket [chemical binding]; other site 768066004448 membrane-bound complex binding site; other site 768066004449 hinge residues; other site 768066004450 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768066004451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066004452 dimer interface [polypeptide binding]; other site 768066004453 conserved gate region; other site 768066004454 putative PBP binding loops; other site 768066004455 ABC-ATPase subunit interface; other site 768066004456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066004457 dimer interface [polypeptide binding]; other site 768066004458 conserved gate region; other site 768066004459 putative PBP binding loops; other site 768066004460 ABC-ATPase subunit interface; other site 768066004461 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 768066004462 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768066004463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066004464 ABC-ATPase subunit interface; other site 768066004465 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 768066004466 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 768066004467 Walker A/P-loop; other site 768066004468 ATP binding site [chemical binding]; other site 768066004469 Q-loop/lid; other site 768066004470 ABC transporter signature motif; other site 768066004471 Walker B; other site 768066004472 D-loop; other site 768066004473 H-loop/switch region; other site 768066004474 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 768066004475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066004476 ABC-ATPase subunit interface; other site 768066004477 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 768066004478 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 768066004479 tetramer interface [polypeptide binding]; other site 768066004480 TPP-binding site [chemical binding]; other site 768066004481 heterodimer interface [polypeptide binding]; other site 768066004482 phosphorylation loop region [posttranslational modification] 768066004483 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 768066004484 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 768066004485 alpha subunit interface [polypeptide binding]; other site 768066004486 TPP binding site [chemical binding]; other site 768066004487 heterodimer interface [polypeptide binding]; other site 768066004488 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768066004489 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 768066004490 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768066004491 E3 interaction surface; other site 768066004492 lipoyl attachment site [posttranslational modification]; other site 768066004493 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768066004494 E3 interaction surface; other site 768066004495 lipoyl attachment site [posttranslational modification]; other site 768066004496 e3 binding domain; Region: E3_binding; pfam02817 768066004497 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768066004498 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 768066004499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066004500 sequence-specific DNA binding site [nucleotide binding]; other site 768066004501 salt bridge; other site 768066004502 Protein kinase domain; Region: Pkinase; pfam00069 768066004503 Catalytic domain of Protein Kinases; Region: PKc; cd00180 768066004504 active site 768066004505 ATP binding site [chemical binding]; other site 768066004506 substrate binding site [chemical binding]; other site 768066004507 activation loop (A-loop); other site 768066004508 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768066004509 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768066004510 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 768066004511 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 768066004512 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 768066004513 putative active site [active] 768066004514 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 768066004515 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 768066004516 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 768066004517 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 768066004518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066004519 DNA-binding site [nucleotide binding]; DNA binding site 768066004520 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768066004521 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 768066004522 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 768066004523 putative active site [active] 768066004524 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768066004525 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768066004526 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 768066004527 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768066004528 TrkA-C domain; Region: TrkA_C; pfam02080 768066004529 TrkA-C domain; Region: TrkA_C; pfam02080 768066004530 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 768066004531 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 768066004532 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768066004533 active site 768066004534 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 768066004535 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 768066004536 Active Sites [active] 768066004537 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 768066004538 four helix bundle protein; Region: TIGR02436 768066004539 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 768066004540 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 768066004541 CysD dimerization site [polypeptide binding]; other site 768066004542 G1 box; other site 768066004543 putative GEF interaction site [polypeptide binding]; other site 768066004544 GTP/Mg2+ binding site [chemical binding]; other site 768066004545 Switch I region; other site 768066004546 G2 box; other site 768066004547 G3 box; other site 768066004548 Switch II region; other site 768066004549 G4 box; other site 768066004550 G5 box; other site 768066004551 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 768066004552 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 768066004553 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 768066004554 ligand-binding site [chemical binding]; other site 768066004555 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 768066004556 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 768066004557 SLBB domain; Region: SLBB; pfam10531 768066004558 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 768066004559 ABC-2 type transporter; Region: ABC2_membrane; cl17235 768066004560 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 768066004561 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 768066004562 Walker A/P-loop; other site 768066004563 ATP binding site [chemical binding]; other site 768066004564 Q-loop/lid; other site 768066004565 ABC transporter signature motif; other site 768066004566 Walker B; other site 768066004567 D-loop; other site 768066004568 H-loop/switch region; other site 768066004569 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 768066004570 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768066004571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768066004572 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 768066004573 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 768066004574 NAD binding site [chemical binding]; other site 768066004575 substrate binding site [chemical binding]; other site 768066004576 homodimer interface [polypeptide binding]; other site 768066004577 active site 768066004578 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 768066004579 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 768066004580 substrate binding site; other site 768066004581 tetramer interface; other site 768066004582 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 768066004583 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768066004584 NAD binding site [chemical binding]; other site 768066004585 homodimer interface [polypeptide binding]; other site 768066004586 active site 768066004587 substrate binding site [chemical binding]; other site 768066004588 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 768066004589 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 768066004590 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 768066004591 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 768066004592 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768066004593 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 768066004594 protein-splicing catalytic site; other site 768066004595 thioester formation/cholesterol transfer; other site 768066004596 hypothetical protein; Provisional; Region: PRK11469 768066004597 Domain of unknown function DUF; Region: DUF204; pfam02659 768066004598 Domain of unknown function DUF; Region: DUF204; pfam02659 768066004599 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066004600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066004601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066004602 dimerization interface [polypeptide binding]; other site 768066004603 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 768066004604 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768066004605 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 768066004606 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768066004607 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 768066004608 substrate-cofactor binding pocket; other site 768066004609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066004610 catalytic residue [active] 768066004611 Sulfatase; Region: Sulfatase; cl17466 768066004612 short chain dehydrogenase; Provisional; Region: PRK07024 768066004613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066004614 NAD(P) binding site [chemical binding]; other site 768066004615 active site 768066004616 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 768066004617 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 768066004618 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 768066004619 Hemin uptake protein hemP; Region: hemP; cl10043 768066004620 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 768066004621 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066004622 N-terminal plug; other site 768066004623 ligand-binding site [chemical binding]; other site 768066004624 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 768066004625 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 768066004626 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 768066004627 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 768066004628 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768066004629 putative hemin binding site; other site 768066004630 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066004631 ABC-ATPase subunit interface; other site 768066004632 dimer interface [polypeptide binding]; other site 768066004633 putative PBP binding regions; other site 768066004634 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768066004635 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768066004636 Walker A/P-loop; other site 768066004637 ATP binding site [chemical binding]; other site 768066004638 Q-loop/lid; other site 768066004639 ABC transporter signature motif; other site 768066004640 Walker B; other site 768066004641 D-loop; other site 768066004642 H-loop/switch region; other site 768066004643 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 768066004644 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 768066004645 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 768066004646 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 768066004647 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 768066004648 G1 box; other site 768066004649 putative GEF interaction site [polypeptide binding]; other site 768066004650 GTP/Mg2+ binding site [chemical binding]; other site 768066004651 Switch I region; other site 768066004652 G2 box; other site 768066004653 G3 box; other site 768066004654 Switch II region; other site 768066004655 G4 box; other site 768066004656 G5 box; other site 768066004657 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 768066004658 AMP-binding domain protein; Validated; Region: PRK08315 768066004659 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768066004660 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 768066004661 acyl-activating enzyme (AAE) consensus motif; other site 768066004662 putative AMP binding site [chemical binding]; other site 768066004663 putative active site [active] 768066004664 putative CoA binding site [chemical binding]; other site 768066004665 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 768066004666 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 768066004667 DNA binding residues [nucleotide binding] 768066004668 putative dimer interface [polypeptide binding]; other site 768066004669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768066004670 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768066004671 active site 768066004672 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 768066004673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768066004674 substrate binding site [chemical binding]; other site 768066004675 oxyanion hole (OAH) forming residues; other site 768066004676 trimer interface [polypeptide binding]; other site 768066004677 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 768066004678 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768066004679 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 768066004680 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 768066004681 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768066004682 FAD binding site [chemical binding]; other site 768066004683 substrate binding pocket [chemical binding]; other site 768066004684 catalytic base [active] 768066004685 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 768066004686 CoA-transferase family III; Region: CoA_transf_3; pfam02515 768066004687 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 768066004688 Imelysin; Region: Peptidase_M75; pfam09375 768066004689 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 768066004690 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 768066004691 Imelysin; Region: Peptidase_M75; cl09159 768066004692 PEP synthetase regulatory protein; Provisional; Region: PRK05339 768066004693 phosphoenolpyruvate synthase; Validated; Region: PRK06464 768066004694 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768066004695 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768066004696 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768066004697 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 768066004698 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 768066004699 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 768066004700 active site 768066004701 catalytic site [active] 768066004702 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 768066004703 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 768066004704 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 768066004705 substrate binding site [chemical binding]; other site 768066004706 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 768066004707 substrate binding site [chemical binding]; other site 768066004708 ligand binding site [chemical binding]; other site 768066004709 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 768066004710 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 768066004711 active site 768066004712 dinuclear metal binding site [ion binding]; other site 768066004713 dimerization interface [polypeptide binding]; other site 768066004714 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 768066004715 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 768066004716 AAA ATPase domain; Region: AAA_16; pfam13191 768066004717 Flagellin N-methylase; Region: FliB; cl00497 768066004718 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 768066004719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066004720 FeS/SAM binding site; other site 768066004721 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 768066004722 Ligand Binding Site [chemical binding]; other site 768066004723 putative protease; Provisional; Region: PRK15452 768066004724 Peptidase family U32; Region: Peptidase_U32; pfam01136 768066004725 Peptidase family U32; Region: Peptidase_U32; pfam01136 768066004726 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 768066004727 hydrophobic ligand binding site; other site 768066004728 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 768066004729 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 768066004730 active site 768066004731 homodimer interface [polypeptide binding]; other site 768066004732 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 768066004733 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768066004734 DEAD-like helicases superfamily; Region: DEXDc; smart00487 768066004735 ATP binding site [chemical binding]; other site 768066004736 Mg++ binding site [ion binding]; other site 768066004737 motif III; other site 768066004738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066004739 nucleotide binding region [chemical binding]; other site 768066004740 ATP-binding site [chemical binding]; other site 768066004741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 768066004742 Protein of unknown function (DUF330); Region: DUF330; pfam03886 768066004743 paraquat-inducible protein B; Provisional; Region: PRK10807 768066004744 mce related protein; Region: MCE; pfam02470 768066004745 mce related protein; Region: MCE; pfam02470 768066004746 mce related protein; Region: MCE; pfam02470 768066004747 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 768066004748 Paraquat-inducible protein A; Region: PqiA; pfam04403 768066004749 Paraquat-inducible protein A; Region: PqiA; pfam04403 768066004750 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 768066004751 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768066004752 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 768066004753 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 768066004754 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 768066004755 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 768066004756 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 768066004757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768066004758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066004759 Walker A/P-loop; other site 768066004760 ATP binding site [chemical binding]; other site 768066004761 Q-loop/lid; other site 768066004762 ABC transporter signature motif; other site 768066004763 Walker B; other site 768066004764 D-loop; other site 768066004765 H-loop/switch region; other site 768066004766 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 768066004767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066004768 Walker A/P-loop; other site 768066004769 ATP binding site [chemical binding]; other site 768066004770 Q-loop/lid; other site 768066004771 ABC transporter signature motif; other site 768066004772 Walker B; other site 768066004773 D-loop; other site 768066004774 H-loop/switch region; other site 768066004775 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 768066004776 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 768066004777 active site 768066004778 purine riboside binding site [chemical binding]; other site 768066004779 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 768066004780 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 768066004781 Potassium binding sites [ion binding]; other site 768066004782 Cesium cation binding sites [ion binding]; other site 768066004783 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 768066004784 guanine deaminase; Provisional; Region: PRK09228 768066004785 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768066004786 active site 768066004787 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 768066004788 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 768066004789 XdhC Rossmann domain; Region: XdhC_C; pfam13478 768066004790 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 768066004791 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 768066004792 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 768066004793 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 768066004794 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768066004795 catalytic loop [active] 768066004796 iron binding site [ion binding]; other site 768066004797 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 768066004798 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 768066004799 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 768066004800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066004801 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 768066004802 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768066004803 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 768066004804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768066004805 ATP binding site [chemical binding]; other site 768066004806 putative Mg++ binding site [ion binding]; other site 768066004807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 768066004808 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 768066004809 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 768066004810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 768066004811 SEC-C motif; Region: SEC-C; pfam02810 768066004812 Protein of unknown function (DUF461); Region: DUF461; pfam04314 768066004813 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 768066004814 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 768066004815 Cu(I) binding site [ion binding]; other site 768066004816 Predicted permease [General function prediction only]; Region: COG2056 768066004817 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 768066004818 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 768066004819 active sites [active] 768066004820 tetramer interface [polypeptide binding]; other site 768066004821 urocanate hydratase; Provisional; Region: PRK05414 768066004822 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 768066004823 putative active site [active] 768066004824 putative metal binding site [ion binding]; other site 768066004825 imidazolonepropionase; Validated; Region: PRK09356 768066004826 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 768066004827 active site 768066004828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 768066004829 Nucleoside recognition; Region: Gate; pfam07670 768066004830 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 768066004831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066004832 DNA-binding site [nucleotide binding]; DNA binding site 768066004833 UTRA domain; Region: UTRA; pfam07702 768066004834 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768066004835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066004836 S-adenosylmethionine binding site [chemical binding]; other site 768066004837 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 768066004838 MarR family; Region: MarR_2; pfam12802 768066004839 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 768066004840 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768066004841 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768066004842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066004843 dimer interface [polypeptide binding]; other site 768066004844 conserved gate region; other site 768066004845 putative PBP binding loops; other site 768066004846 ABC-ATPase subunit interface; other site 768066004847 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768066004848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066004849 dimer interface [polypeptide binding]; other site 768066004850 conserved gate region; other site 768066004851 putative PBP binding loops; other site 768066004852 ABC-ATPase subunit interface; other site 768066004853 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 768066004854 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768066004855 Walker A/P-loop; other site 768066004856 ATP binding site [chemical binding]; other site 768066004857 Q-loop/lid; other site 768066004858 ABC transporter signature motif; other site 768066004859 Walker B; other site 768066004860 D-loop; other site 768066004861 H-loop/switch region; other site 768066004862 TOBE domain; Region: TOBE_2; pfam08402 768066004863 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 768066004864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066004865 motif II; other site 768066004866 sorbitol dehydrogenase; Provisional; Region: PRK07067 768066004867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066004868 NAD(P) binding site [chemical binding]; other site 768066004869 active site 768066004870 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 768066004871 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 768066004872 active site 768066004873 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 768066004874 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 768066004875 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768066004876 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 768066004877 N- and C-terminal domain interface [polypeptide binding]; other site 768066004878 D-xylulose kinase; Region: XylB; TIGR01312 768066004879 active site 768066004880 MgATP binding site [chemical binding]; other site 768066004881 catalytic site [active] 768066004882 metal binding site [ion binding]; metal-binding site 768066004883 xylulose binding site [chemical binding]; other site 768066004884 putative homodimer interface [polypeptide binding]; other site 768066004885 transaldolase-like protein; Provisional; Region: PTZ00411 768066004886 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768066004887 active site 768066004888 dimer interface [polypeptide binding]; other site 768066004889 catalytic residue [active] 768066004890 multidrug resistance protein MdtN; Provisional; Region: PRK10476 768066004891 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768066004892 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066004893 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 768066004894 AAA domain; Region: AAA_17; cl17253 768066004895 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 768066004896 CoA binding domain; Region: CoA_binding_2; pfam13380 768066004897 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 768066004898 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 768066004899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768066004900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066004901 Coenzyme A binding pocket [chemical binding]; other site 768066004902 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 768066004903 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768066004904 catalytic Zn binding site [ion binding]; other site 768066004905 structural Zn binding site [ion binding]; other site 768066004906 NAD(P) binding site [chemical binding]; other site 768066004907 LrgA family; Region: LrgA; pfam03788 768066004908 LrgB-like family; Region: LrgB; pfam04172 768066004909 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 768066004910 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 768066004911 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 768066004912 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768066004913 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768066004914 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 768066004915 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 768066004916 Subunit I/III interface [polypeptide binding]; other site 768066004917 D-pathway; other site 768066004918 Subunit I/VIIc interface [polypeptide binding]; other site 768066004919 Subunit I/IV interface [polypeptide binding]; other site 768066004920 Subunit I/II interface [polypeptide binding]; other site 768066004921 Low-spin heme (heme a) binding site [chemical binding]; other site 768066004922 Subunit I/VIIa interface [polypeptide binding]; other site 768066004923 Subunit I/VIa interface [polypeptide binding]; other site 768066004924 Dimer interface; other site 768066004925 Putative water exit pathway; other site 768066004926 Binuclear center (heme a3/CuB) [ion binding]; other site 768066004927 K-pathway; other site 768066004928 Subunit I/Vb interface [polypeptide binding]; other site 768066004929 Putative proton exit pathway; other site 768066004930 Subunit I/VIb interface; other site 768066004931 Subunit I/VIc interface [polypeptide binding]; other site 768066004932 Electron transfer pathway; other site 768066004933 Subunit I/VIIIb interface [polypeptide binding]; other site 768066004934 Subunit I/VIIb interface [polypeptide binding]; other site 768066004935 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 768066004936 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 768066004937 Subunit III/VIIa interface [polypeptide binding]; other site 768066004938 Phospholipid binding site [chemical binding]; other site 768066004939 Subunit I/III interface [polypeptide binding]; other site 768066004940 Subunit III/VIb interface [polypeptide binding]; other site 768066004941 Subunit III/VIa interface; other site 768066004942 Subunit III/Vb interface [polypeptide binding]; other site 768066004943 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 768066004944 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 768066004945 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 768066004946 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 768066004947 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 768066004948 UbiA prenyltransferase family; Region: UbiA; pfam01040 768066004949 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768066004950 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 768066004951 transmembrane helices; other site 768066004952 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 768066004953 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 768066004954 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768066004955 ligand binding site [chemical binding]; other site 768066004956 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 768066004957 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 768066004958 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 768066004959 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 768066004960 active site 768066004961 dimer interface [polypeptide binding]; other site 768066004962 motif 1; other site 768066004963 motif 2; other site 768066004964 motif 3; other site 768066004965 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 768066004966 anticodon binding site; other site 768066004967 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 768066004968 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 768066004969 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 768066004970 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 768066004971 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768066004972 23S rRNA binding site [nucleotide binding]; other site 768066004973 L21 binding site [polypeptide binding]; other site 768066004974 L13 binding site [polypeptide binding]; other site 768066004975 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 768066004976 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 768066004977 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 768066004978 dimer interface [polypeptide binding]; other site 768066004979 motif 1; other site 768066004980 active site 768066004981 motif 2; other site 768066004982 motif 3; other site 768066004983 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 768066004984 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768066004985 putative tRNA-binding site [nucleotide binding]; other site 768066004986 B3/4 domain; Region: B3_4; pfam03483 768066004987 tRNA synthetase B5 domain; Region: B5; smart00874 768066004988 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 768066004989 dimer interface [polypeptide binding]; other site 768066004990 motif 1; other site 768066004991 motif 3; other site 768066004992 motif 2; other site 768066004993 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 768066004994 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768066004995 IHF - DNA interface [nucleotide binding]; other site 768066004996 IHF dimer interface [polypeptide binding]; other site 768066004997 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 768066004998 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768066004999 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 768066005000 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 768066005001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066005002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066005003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768066005004 dimerization interface [polypeptide binding]; other site 768066005005 glycine dehydrogenase; Provisional; Region: PRK05367 768066005006 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768066005007 tetramer interface [polypeptide binding]; other site 768066005008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066005009 catalytic residue [active] 768066005010 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 768066005011 tetramer interface [polypeptide binding]; other site 768066005012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066005013 catalytic residue [active] 768066005014 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 768066005015 lipoyl attachment site [posttranslational modification]; other site 768066005016 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768066005017 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 768066005018 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 768066005019 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 768066005020 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 768066005021 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768066005022 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 768066005023 active site 768066005024 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768066005025 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 768066005026 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768066005027 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768066005028 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768066005029 Peptidase family M23; Region: Peptidase_M23; pfam01551 768066005030 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768066005031 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 768066005032 putative acyl-acceptor binding pocket; other site 768066005033 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 768066005034 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 768066005035 acyl-activating enzyme (AAE) consensus motif; other site 768066005036 putative AMP binding site [chemical binding]; other site 768066005037 putative active site [active] 768066005038 putative CoA binding site [chemical binding]; other site 768066005039 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066005040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066005041 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 768066005042 putative dimerization interface [polypeptide binding]; other site 768066005043 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 768066005044 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 768066005045 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 768066005046 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 768066005047 GSH binding site [chemical binding]; other site 768066005048 catalytic residues [active] 768066005049 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768066005050 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 768066005051 active site 768066005052 dimerization interface [polypeptide binding]; other site 768066005053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066005054 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 768066005055 NAD(P) binding site [chemical binding]; other site 768066005056 active site 768066005057 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768066005058 active site 768066005059 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 768066005060 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 768066005061 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 768066005062 excinuclease ABC subunit B; Provisional; Region: PRK05298 768066005063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768066005064 ATP binding site [chemical binding]; other site 768066005065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066005066 nucleotide binding region [chemical binding]; other site 768066005067 ATP-binding site [chemical binding]; other site 768066005068 Ultra-violet resistance protein B; Region: UvrB; pfam12344 768066005069 UvrB/uvrC motif; Region: UVR; pfam02151 768066005070 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 768066005071 Fumarase C-terminus; Region: Fumerase_C; pfam05683 768066005072 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 768066005073 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768066005074 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 768066005075 putative active site [active] 768066005076 catalytic site [active] 768066005077 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 768066005078 putative active site [active] 768066005079 catalytic site [active] 768066005080 cell density-dependent motility repressor; Provisional; Region: PRK10082 768066005081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066005082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768066005083 dimerization interface [polypeptide binding]; other site 768066005084 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 768066005085 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768066005086 active site 768066005087 nucleotide binding site [chemical binding]; other site 768066005088 HIGH motif; other site 768066005089 KMSKS motif; other site 768066005090 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 768066005091 nudix motif; other site 768066005092 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 768066005093 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 768066005094 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 768066005095 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 768066005096 NAD binding site [chemical binding]; other site 768066005097 Phe binding site; other site 768066005098 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 768066005099 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 768066005100 active site 768066005101 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768066005102 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 768066005103 substrate binding site [chemical binding]; other site 768066005104 dimer interface [polypeptide binding]; other site 768066005105 ATP binding site [chemical binding]; other site 768066005106 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 768066005107 glycerate dehydrogenase; Provisional; Region: PRK06487 768066005108 putative ligand binding site [chemical binding]; other site 768066005109 putative NAD binding site [chemical binding]; other site 768066005110 catalytic site [active] 768066005111 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 768066005112 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 768066005113 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 768066005114 dimer interface [polypeptide binding]; other site 768066005115 anticodon binding site; other site 768066005116 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768066005117 homodimer interface [polypeptide binding]; other site 768066005118 motif 1; other site 768066005119 active site 768066005120 motif 2; other site 768066005121 GAD domain; Region: GAD; pfam02938 768066005122 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768066005123 active site 768066005124 motif 3; other site 768066005125 hypothetical protein; Validated; Region: PRK00110 768066005126 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 768066005127 active site 768066005128 putative DNA-binding cleft [nucleotide binding]; other site 768066005129 dimer interface [polypeptide binding]; other site 768066005130 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 768066005131 RuvA N terminal domain; Region: RuvA_N; pfam01330 768066005132 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 768066005133 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 768066005134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066005135 Walker A motif; other site 768066005136 ATP binding site [chemical binding]; other site 768066005137 Walker B motif; other site 768066005138 arginine finger; other site 768066005139 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 768066005140 TolQ protein; Region: tolQ; TIGR02796 768066005141 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768066005142 TolR protein; Region: tolR; TIGR02801 768066005143 TolA protein; Region: tolA_full; TIGR02794 768066005144 TonB C terminal; Region: TonB_2; pfam13103 768066005145 translocation protein TolB; Provisional; Region: tolB; PRK00178 768066005146 TolB amino-terminal domain; Region: TolB_N; pfam04052 768066005147 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768066005148 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768066005149 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 768066005150 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768066005151 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 768066005152 ligand binding site [chemical binding]; other site 768066005153 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 768066005154 Tetratricopeptide repeat; Region: TPR_6; pfam13174 768066005155 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 768066005156 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 768066005157 NADP binding site [chemical binding]; other site 768066005158 homodimer interface [polypeptide binding]; other site 768066005159 active site 768066005160 phosphoglycolate phosphatase; Provisional; Region: PRK13222 768066005161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066005162 motif II; other site 768066005163 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 768066005164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066005165 S-adenosylmethionine binding site [chemical binding]; other site 768066005166 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768066005167 active site 768066005168 tetramer interface; other site 768066005169 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 768066005170 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768066005171 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 768066005172 superoxide dismutase; Provisional; Region: PRK10543 768066005173 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768066005174 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768066005175 Herpes virus major capsid protein; Region: Herpes_MCP; pfam03122 768066005176 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 768066005177 Surface antigen; Region: Bac_surface_Ag; pfam01103 768066005178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 768066005179 Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481 768066005180 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768066005181 Family of unknown function (DUF490); Region: DUF490; pfam04357 768066005182 methionine sulfoxide reductase A; Provisional; Region: PRK00058 768066005183 putative hydrolase; Provisional; Region: PRK10985 768066005184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066005185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066005186 LysR substrate binding domain; Region: LysR_substrate; pfam03466 768066005187 dimerization interface [polypeptide binding]; other site 768066005188 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 768066005189 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768066005190 Walker A/P-loop; other site 768066005191 ATP binding site [chemical binding]; other site 768066005192 Q-loop/lid; other site 768066005193 ABC transporter signature motif; other site 768066005194 Walker B; other site 768066005195 D-loop; other site 768066005196 H-loop/switch region; other site 768066005197 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768066005198 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768066005199 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768066005200 Walker A/P-loop; other site 768066005201 ATP binding site [chemical binding]; other site 768066005202 Q-loop/lid; other site 768066005203 ABC transporter signature motif; other site 768066005204 Walker B; other site 768066005205 D-loop; other site 768066005206 H-loop/switch region; other site 768066005207 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 768066005208 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 768066005209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066005210 dimer interface [polypeptide binding]; other site 768066005211 conserved gate region; other site 768066005212 putative PBP binding loops; other site 768066005213 ABC-ATPase subunit interface; other site 768066005214 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768066005215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066005216 dimer interface [polypeptide binding]; other site 768066005217 conserved gate region; other site 768066005218 putative PBP binding loops; other site 768066005219 ABC-ATPase subunit interface; other site 768066005220 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 768066005221 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 768066005222 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 768066005223 active site clefts [active] 768066005224 zinc binding site [ion binding]; other site 768066005225 dimer interface [polypeptide binding]; other site 768066005226 glutathione reductase; Validated; Region: PRK06116 768066005227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066005228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066005229 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768066005230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768066005231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066005232 Coenzyme A binding pocket [chemical binding]; other site 768066005233 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 768066005234 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066005235 inhibitor-cofactor binding pocket; inhibition site 768066005236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066005237 catalytic residue [active] 768066005238 Ectoine synthase; Region: Ectoine_synth; pfam06339 768066005239 Cupin; Region: Cupin_6; pfam12852 768066005240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066005241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768066005242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066005243 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768066005244 putative active site [active] 768066005245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 768066005246 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 768066005247 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 768066005248 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 768066005249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066005250 putative substrate translocation pore; other site 768066005251 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 768066005252 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 768066005253 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 768066005254 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 768066005255 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 768066005256 Haemolytic domain; Region: Haemolytic; pfam01809 768066005257 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 768066005258 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 768066005259 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768066005260 active site 768066005261 DNA binding site [nucleotide binding] 768066005262 Int/Topo IB signature motif; other site 768066005263 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 768066005264 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 768066005265 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 768066005266 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 768066005267 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 768066005268 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 768066005269 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 768066005270 substrate binding pocket [chemical binding]; other site 768066005271 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 768066005272 B12 binding site [chemical binding]; other site 768066005273 cobalt ligand [ion binding]; other site 768066005274 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 768066005275 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 768066005276 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 768066005277 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 768066005278 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768066005279 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768066005280 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 768066005281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 768066005282 Smr domain; Region: Smr; pfam01713 768066005283 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768066005284 putative active site pocket [active] 768066005285 dimerization interface [polypeptide binding]; other site 768066005286 putative catalytic residue [active] 768066005287 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 768066005288 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 768066005289 ArsC family; Region: ArsC; pfam03960 768066005290 catalytic residues [active] 768066005291 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768066005292 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768066005293 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 768066005294 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 768066005295 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 768066005296 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 768066005297 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 768066005298 CoA binding domain; Region: CoA_binding_2; pfam13380 768066005299 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 768066005300 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 768066005301 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 768066005302 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768066005303 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 768066005304 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 768066005305 putative active site [active] 768066005306 Zn binding site [ion binding]; other site 768066005307 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768066005308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066005309 non-specific DNA binding site [nucleotide binding]; other site 768066005310 salt bridge; other site 768066005311 sequence-specific DNA binding site [nucleotide binding]; other site 768066005312 Cupin domain; Region: Cupin_2; pfam07883 768066005313 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 768066005314 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768066005315 MPT binding site; other site 768066005316 trimer interface [polypeptide binding]; other site 768066005317 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 768066005318 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 768066005319 dimer interface [polypeptide binding]; other site 768066005320 putative functional site; other site 768066005321 putative MPT binding site; other site 768066005322 Protein of unknown function, DUF479; Region: DUF479; cl01203 768066005323 DsrC like protein; Region: DsrC; pfam04358 768066005324 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 768066005325 DsrH like protein; Region: DsrH; cl17347 768066005326 DsrE/DsrF-like family; Region: DrsE; cl00672 768066005327 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 768066005328 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 768066005329 YccA-like proteins; Region: YccA_like; cd10433 768066005330 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 768066005331 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 768066005332 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768066005333 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 768066005334 FOG: WD40 repeat [General function prediction only]; Region: COG2319 768066005335 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 768066005336 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 768066005337 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 768066005338 catalytic residue [active] 768066005339 Protein of unknown function (DUF968); Region: DUF968; pfam06147 768066005340 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 768066005341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066005342 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768066005343 Walker A motif; other site 768066005344 ATP binding site [chemical binding]; other site 768066005345 Walker B motif; other site 768066005346 arginine finger; other site 768066005347 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 768066005348 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 768066005349 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768066005350 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768066005351 substrate interaction site [chemical binding]; other site 768066005352 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 768066005353 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 768066005354 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768066005355 active site 768066005356 DNA binding site [nucleotide binding] 768066005357 Int/Topo IB signature motif; other site 768066005358 Hint domain; Region: Hint_2; pfam13403 768066005359 V-type ATP synthase subunit A; Provisional; Region: PRK04192 768066005360 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 768066005361 Walker A motif/ATP binding site; other site 768066005362 Walker B motif; other site 768066005363 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768066005364 V-type ATP synthase subunit E; Provisional; Region: PRK01005 768066005365 V-type ATP synthase subunit E; Provisional; Region: PRK01558 768066005366 V-type ATP synthase subunit K; Provisional; Region: PRK09621 768066005367 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 768066005368 V-type ATP synthase subunit I; Validated; Region: PRK05771 768066005369 ATP synthase subunit D; Region: ATP-synt_D; cl00613 768066005370 V-type ATP synthase subunit B; Provisional; Region: PRK02118 768066005371 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768066005372 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 768066005373 Walker A motif homologous position; other site 768066005374 Walker B motif; other site 768066005375 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 768066005376 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 768066005377 putative substrate binding site [chemical binding]; other site 768066005378 nucleotide binding site [chemical binding]; other site 768066005379 nucleotide binding site [chemical binding]; other site 768066005380 homodimer interface [polypeptide binding]; other site 768066005381 ornithine carbamoyltransferase; Validated; Region: PRK02102 768066005382 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768066005383 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768066005384 arginine deiminase; Provisional; Region: PRK01388 768066005385 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 768066005386 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 768066005387 Domain of unknown function DUF21; Region: DUF21; pfam01595 768066005388 FOG: CBS domain [General function prediction only]; Region: COG0517 768066005389 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768066005390 hypothetical protein; Provisional; Region: PRK10457 768066005391 potassium/proton antiporter; Reviewed; Region: PRK05326 768066005392 TrkA-C domain; Region: TrkA_C; pfam02080 768066005393 Transporter associated domain; Region: CorC_HlyC; smart01091 768066005394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 768066005395 NMT1/THI5 like; Region: NMT1; pfam09084 768066005396 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768066005397 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 768066005398 hypothetical protein; Provisional; Region: PRK11212 768066005399 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 768066005400 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 768066005401 acyl-activating enzyme (AAE) consensus motif; other site 768066005402 putative AMP binding site [chemical binding]; other site 768066005403 putative active site [active] 768066005404 putative CoA binding site [chemical binding]; other site 768066005405 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768066005406 dimerization interface [polypeptide binding]; other site 768066005407 putative DNA binding site [nucleotide binding]; other site 768066005408 putative Zn2+ binding site [ion binding]; other site 768066005409 putative inner membrane peptidase; Provisional; Region: PRK11778 768066005410 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768066005411 tandem repeat interface [polypeptide binding]; other site 768066005412 oligomer interface [polypeptide binding]; other site 768066005413 active site residues [active] 768066005414 SCP-2 sterol transfer family; Region: SCP2; pfam02036 768066005415 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 768066005416 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 768066005417 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 768066005418 putative NADH binding site [chemical binding]; other site 768066005419 putative active site [active] 768066005420 nudix motif; other site 768066005421 putative metal binding site [ion binding]; other site 768066005422 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 768066005423 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 768066005424 active site 768066005425 catalytic site [active] 768066005426 substrate binding site [chemical binding]; other site 768066005427 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 768066005428 RNA/DNA hybrid binding site [nucleotide binding]; other site 768066005429 active site 768066005430 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 768066005431 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768066005432 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768066005433 catalytic residue [active] 768066005434 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768066005435 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768066005436 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 768066005437 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 768066005438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066005439 dimer interface [polypeptide binding]; other site 768066005440 conserved gate region; other site 768066005441 putative PBP binding loops; other site 768066005442 ABC-ATPase subunit interface; other site 768066005443 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 768066005444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066005445 dimer interface [polypeptide binding]; other site 768066005446 conserved gate region; other site 768066005447 ABC-ATPase subunit interface; other site 768066005448 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 768066005449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768066005450 Walker A/P-loop; other site 768066005451 ATP binding site [chemical binding]; other site 768066005452 Q-loop/lid; other site 768066005453 ABC transporter signature motif; other site 768066005454 Walker B; other site 768066005455 D-loop; other site 768066005456 H-loop/switch region; other site 768066005457 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768066005458 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768066005459 Walker A/P-loop; other site 768066005460 ATP binding site [chemical binding]; other site 768066005461 Q-loop/lid; other site 768066005462 ABC transporter signature motif; other site 768066005463 Walker B; other site 768066005464 D-loop; other site 768066005465 H-loop/switch region; other site 768066005466 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 768066005467 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768066005468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768066005469 metal binding site [ion binding]; metal-binding site 768066005470 active site 768066005471 I-site; other site 768066005472 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 768066005473 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768066005474 RNA binding surface [nucleotide binding]; other site 768066005475 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 768066005476 active site 768066005477 uracil binding [chemical binding]; other site 768066005478 C-N hydrolase family amidase; Provisional; Region: PRK10438 768066005479 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 768066005480 putative active site [active] 768066005481 catalytic triad [active] 768066005482 dimer interface [polypeptide binding]; other site 768066005483 multimer interface [polypeptide binding]; other site 768066005484 Predicted permeases [General function prediction only]; Region: RarD; COG2962 768066005485 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768066005486 high affinity sulphate transporter 1; Region: sulP; TIGR00815 768066005487 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768066005488 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768066005489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066005490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066005491 dimer interface [polypeptide binding]; other site 768066005492 phosphorylation site [posttranslational modification] 768066005493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066005494 ATP binding site [chemical binding]; other site 768066005495 G-X-G motif; other site 768066005496 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 768066005497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066005498 active site 768066005499 phosphorylation site [posttranslational modification] 768066005500 intermolecular recognition site; other site 768066005501 dimerization interface [polypeptide binding]; other site 768066005502 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768066005503 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768066005504 active site 768066005505 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 768066005506 beta-hexosaminidase; Provisional; Region: PRK05337 768066005507 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 768066005508 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 768066005509 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 768066005510 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 768066005511 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 768066005512 CoA-binding site [chemical binding]; other site 768066005513 ATP-binding [chemical binding]; other site 768066005514 Domain of unknown function (DUF329); Region: DUF329; cl01144 768066005515 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 768066005516 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 768066005517 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 768066005518 RNA binding site [nucleotide binding]; other site 768066005519 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 768066005520 RNA binding site [nucleotide binding]; other site 768066005521 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 768066005522 RNA binding site [nucleotide binding]; other site 768066005523 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768066005524 RNA binding site [nucleotide binding]; other site 768066005525 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 768066005526 RNA binding site [nucleotide binding]; other site 768066005527 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 768066005528 RNA binding site [nucleotide binding]; other site 768066005529 cytidylate kinase; Provisional; Region: cmk; PRK00023 768066005530 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 768066005531 CMP-binding site; other site 768066005532 The sites determining sugar specificity; other site 768066005533 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 768066005534 prephenate dehydrogenase; Validated; Region: PRK08507 768066005535 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 768066005536 hinge; other site 768066005537 active site 768066005538 Chorismate mutase type II; Region: CM_2; cl00693 768066005539 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 768066005540 Prephenate dehydratase; Region: PDT; pfam00800 768066005541 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 768066005542 putative L-Phe binding site [chemical binding]; other site 768066005543 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 768066005544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768066005545 catalytic residue [active] 768066005546 DNA gyrase subunit A; Validated; Region: PRK05560 768066005547 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768066005548 CAP-like domain; other site 768066005549 active site 768066005550 primary dimer interface [polypeptide binding]; other site 768066005551 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768066005552 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768066005553 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768066005554 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768066005555 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768066005556 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768066005557 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768066005558 active site 768066005559 Putative exonuclease, RdgC; Region: RdgC; pfam04381 768066005560 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768066005561 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 768066005562 putative acyl-acceptor binding pocket; other site 768066005563 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768066005564 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 768066005565 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 768066005566 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 768066005567 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 768066005568 Ligand Binding Site [chemical binding]; other site 768066005569 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768066005570 active site residue [active] 768066005571 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 768066005572 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 768066005573 active site 768066005574 HIGH motif; other site 768066005575 KMSKS motif; other site 768066005576 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 768066005577 tRNA binding surface [nucleotide binding]; other site 768066005578 anticodon binding site; other site 768066005579 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 768066005580 dimer interface [polypeptide binding]; other site 768066005581 putative tRNA-binding site [nucleotide binding]; other site 768066005582 ferredoxin; Provisional; Region: PRK08764 768066005583 Putative Fe-S cluster; Region: FeS; pfam04060 768066005584 4Fe-4S binding domain; Region: Fer4; pfam00037 768066005585 endonuclease III; Provisional; Region: PRK10702 768066005586 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768066005587 minor groove reading motif; other site 768066005588 helix-hairpin-helix signature motif; other site 768066005589 substrate binding pocket [chemical binding]; other site 768066005590 active site 768066005591 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768066005592 Sulphur transport; Region: Sulf_transp; pfam04143 768066005593 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 768066005594 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 768066005595 active site residue [active] 768066005596 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 768066005597 active site residue [active] 768066005598 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 768066005599 DTAP/Switch II; other site 768066005600 Switch I; other site 768066005601 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 768066005602 Carbon starvation protein CstA; Region: CstA; pfam02554 768066005603 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 768066005604 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 768066005605 Carbon starvation protein CstA; Region: CstA; pfam02554 768066005606 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 768066005607 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 768066005608 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 768066005609 putative C-terminal domain interface [polypeptide binding]; other site 768066005610 putative GSH binding site (G-site) [chemical binding]; other site 768066005611 putative dimer interface [polypeptide binding]; other site 768066005612 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 768066005613 putative N-terminal domain interface [polypeptide binding]; other site 768066005614 putative dimer interface [polypeptide binding]; other site 768066005615 putative substrate binding pocket (H-site) [chemical binding]; other site 768066005616 Response regulator receiver domain; Region: Response_reg; pfam00072 768066005617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066005618 active site 768066005619 phosphorylation site [posttranslational modification] 768066005620 intermolecular recognition site; other site 768066005621 dimerization interface [polypeptide binding]; other site 768066005622 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768066005623 active site 768066005624 catalytic site [active] 768066005625 substrate binding site [chemical binding]; other site 768066005626 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 768066005627 Na binding site [ion binding]; other site 768066005628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066005629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066005630 dimer interface [polypeptide binding]; other site 768066005631 phosphorylation site [posttranslational modification] 768066005632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066005633 ATP binding site [chemical binding]; other site 768066005634 Mg2+ binding site [ion binding]; other site 768066005635 G-X-G motif; other site 768066005636 Transcriptional activator HlyU; Region: HlyU; pfam10115 768066005637 argininosuccinate synthase; Provisional; Region: PRK13820 768066005638 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 768066005639 ANP binding site [chemical binding]; other site 768066005640 Substrate Binding Site II [chemical binding]; other site 768066005641 Substrate Binding Site I [chemical binding]; other site 768066005642 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 768066005643 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 768066005644 dimer interface [polypeptide binding]; other site 768066005645 catalytic site [active] 768066005646 putative active site [active] 768066005647 putative substrate binding site [chemical binding]; other site 768066005648 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 768066005649 putative GSH binding site [chemical binding]; other site 768066005650 catalytic residues [active] 768066005651 ornithine carbamoyltransferase; Provisional; Region: PRK00779 768066005652 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768066005653 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768066005654 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 768066005655 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 768066005656 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768066005657 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768066005658 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768066005659 active site 768066005660 BCCT family transporter; Region: BCCT; pfam02028 768066005661 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 768066005662 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 768066005663 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066005664 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 768066005665 conserved cys residue [active] 768066005666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066005667 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 768066005668 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 768066005669 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066005670 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 768066005671 conserved cys residue [active] 768066005672 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 768066005673 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 768066005674 substrate binding pocket [chemical binding]; other site 768066005675 active site 768066005676 iron coordination sites [ion binding]; other site 768066005677 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066005678 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 768066005679 conserved cys residue [active] 768066005680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066005681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066005682 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 768066005683 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 768066005684 substrate binding pocket [chemical binding]; other site 768066005685 active site 768066005686 iron coordination sites [ion binding]; other site 768066005687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768066005688 Zn2+ binding site [ion binding]; other site 768066005689 Mg2+ binding site [ion binding]; other site 768066005690 hypothetical protein; Provisional; Region: PRK07524 768066005691 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768066005692 PYR/PP interface [polypeptide binding]; other site 768066005693 dimer interface [polypeptide binding]; other site 768066005694 TPP binding site [chemical binding]; other site 768066005695 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768066005696 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 768066005697 TPP-binding site [chemical binding]; other site 768066005698 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 768066005699 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 768066005700 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 768066005701 intersubunit interface [polypeptide binding]; other site 768066005702 active site 768066005703 Zn2+ binding site [ion binding]; other site 768066005704 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 768066005705 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066005706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066005707 homodimer interface [polypeptide binding]; other site 768066005708 catalytic residue [active] 768066005709 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768066005710 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768066005711 Walker A/P-loop; other site 768066005712 ATP binding site [chemical binding]; other site 768066005713 Q-loop/lid; other site 768066005714 ABC transporter signature motif; other site 768066005715 Walker B; other site 768066005716 D-loop; other site 768066005717 H-loop/switch region; other site 768066005718 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768066005719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768066005720 substrate binding pocket [chemical binding]; other site 768066005721 membrane-bound complex binding site; other site 768066005722 hinge residues; other site 768066005723 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768066005724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066005725 dimer interface [polypeptide binding]; other site 768066005726 conserved gate region; other site 768066005727 putative PBP binding loops; other site 768066005728 ABC-ATPase subunit interface; other site 768066005729 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768066005730 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 768066005731 NAD(P) binding site [chemical binding]; other site 768066005732 catalytic residues [active] 768066005733 catalytic residues [active] 768066005734 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768066005735 EamA-like transporter family; Region: EamA; pfam00892 768066005736 type II secretion system protein D; Region: type_II_gspD; TIGR02517 768066005737 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768066005738 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768066005739 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768066005740 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 768066005741 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 768066005742 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 768066005743 general secretion pathway protein J; Validated; Region: PRK08808 768066005744 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 768066005745 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 768066005746 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 768066005747 type II secretion system protein F; Region: GspF; TIGR02120 768066005748 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768066005749 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768066005750 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 768066005751 type II secretion system protein E; Region: type_II_gspE; TIGR02533 768066005752 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 768066005753 Walker A motif; other site 768066005754 ATP binding site [chemical binding]; other site 768066005755 Walker B motif; other site 768066005756 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 768066005757 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 768066005758 PA14 domain; Region: PA14; pfam07691 768066005759 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 768066005760 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768066005761 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768066005762 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768066005763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066005764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066005765 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 768066005766 SpoOM protein; Region: Spo0M; pfam07070 768066005767 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 768066005768 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768066005769 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768066005770 TM-ABC transporter signature motif; other site 768066005771 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 768066005772 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768066005773 Walker A/P-loop; other site 768066005774 ATP binding site [chemical binding]; other site 768066005775 Q-loop/lid; other site 768066005776 ABC transporter signature motif; other site 768066005777 Walker B; other site 768066005778 D-loop; other site 768066005779 H-loop/switch region; other site 768066005780 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768066005781 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768066005782 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 768066005783 ligand binding site [chemical binding]; other site 768066005784 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768066005785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066005786 dimer interface [polypeptide binding]; other site 768066005787 conserved gate region; other site 768066005788 putative PBP binding loops; other site 768066005789 ABC-ATPase subunit interface; other site 768066005790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066005791 dimer interface [polypeptide binding]; other site 768066005792 conserved gate region; other site 768066005793 putative PBP binding loops; other site 768066005794 ABC-ATPase subunit interface; other site 768066005795 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768066005796 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768066005797 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768066005798 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768066005799 Walker A/P-loop; other site 768066005800 ATP binding site [chemical binding]; other site 768066005801 Q-loop/lid; other site 768066005802 ABC transporter signature motif; other site 768066005803 Walker B; other site 768066005804 D-loop; other site 768066005805 H-loop/switch region; other site 768066005806 TOBE domain; Region: TOBE; pfam03459 768066005807 TOBE domain; Region: TOBE_2; pfam08402 768066005808 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 768066005809 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 768066005810 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 768066005811 active site 768066005812 catalytic residues [active] 768066005813 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 768066005814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066005815 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 768066005816 putative dimerization interface [polypeptide binding]; other site 768066005817 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768066005818 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768066005819 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 768066005820 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 768066005821 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 768066005822 active site 768066005823 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 768066005824 substrate binding site [chemical binding]; other site 768066005825 active site 768066005826 dihydroxy-acid dehydratase; Validated; Region: PRK06131 768066005827 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066005828 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066005829 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066005830 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768066005831 DctM-like transporters; Region: DctM; pfam06808 768066005832 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 768066005833 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 768066005834 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 768066005835 active site 768066005836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 768066005837 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768066005838 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768066005839 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 768066005840 dimer interface [polypeptide binding]; other site 768066005841 NADP binding site [chemical binding]; other site 768066005842 catalytic residues [active] 768066005843 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 768066005844 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768066005845 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768066005846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066005847 DNA-binding site [nucleotide binding]; DNA binding site 768066005848 FCD domain; Region: FCD; pfam07729 768066005849 response regulator; Provisional; Region: PRK09483 768066005850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066005851 active site 768066005852 phosphorylation site [posttranslational modification] 768066005853 intermolecular recognition site; other site 768066005854 dimerization interface [polypeptide binding]; other site 768066005855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768066005856 DNA binding residues [nucleotide binding] 768066005857 dimerization interface [polypeptide binding]; other site 768066005858 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 768066005859 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768066005860 GIY-YIG motif/motif A; other site 768066005861 active site 768066005862 catalytic site [active] 768066005863 putative DNA binding site [nucleotide binding]; other site 768066005864 metal binding site [ion binding]; metal-binding site 768066005865 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 768066005866 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 768066005867 Hint domain; Region: Hint_2; pfam13403 768066005868 Uncharacterized conserved protein [Function unknown]; Region: COG3287 768066005869 FIST N domain; Region: FIST; pfam08495 768066005870 FIST C domain; Region: FIST_C; pfam10442 768066005871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066005872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066005873 dimer interface [polypeptide binding]; other site 768066005874 phosphorylation site [posttranslational modification] 768066005875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066005876 ATP binding site [chemical binding]; other site 768066005877 Mg2+ binding site [ion binding]; other site 768066005878 G-X-G motif; other site 768066005879 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768066005880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066005881 active site 768066005882 phosphorylation site [posttranslational modification] 768066005883 intermolecular recognition site; other site 768066005884 dimerization interface [polypeptide binding]; other site 768066005885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768066005886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066005887 active site 768066005888 phosphorylation site [posttranslational modification] 768066005889 intermolecular recognition site; other site 768066005890 dimerization interface [polypeptide binding]; other site 768066005891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768066005892 DNA binding residues [nucleotide binding] 768066005893 dimerization interface [polypeptide binding]; other site 768066005894 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 768066005895 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768066005896 NAD(P) binding site [chemical binding]; other site 768066005897 catalytic residues [active] 768066005898 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768066005899 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 768066005900 NAD binding site [chemical binding]; other site 768066005901 substrate binding site [chemical binding]; other site 768066005902 catalytic Zn binding site [ion binding]; other site 768066005903 tetramer interface [polypeptide binding]; other site 768066005904 structural Zn binding site [ion binding]; other site 768066005905 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 768066005906 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768066005907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066005908 non-specific DNA binding site [nucleotide binding]; other site 768066005909 salt bridge; other site 768066005910 sequence-specific DNA binding site [nucleotide binding]; other site 768066005911 Cupin domain; Region: Cupin_2; pfam07883 768066005912 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 768066005913 intersubunit interface [polypeptide binding]; other site 768066005914 active site 768066005915 Zn2+ binding site [ion binding]; other site 768066005916 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768066005917 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768066005918 inhibitor site; inhibition site 768066005919 active site 768066005920 dimer interface [polypeptide binding]; other site 768066005921 catalytic residue [active] 768066005922 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 768066005923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066005924 Condensation domain; Region: Condensation; pfam00668 768066005925 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768066005926 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768066005927 Condensation domain; Region: Condensation; pfam00668 768066005928 Nonribosomal peptide synthase; Region: NRPS; pfam08415 768066005929 Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034 768066005930 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 768066005931 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768066005932 acyl-activating enzyme (AAE) consensus motif; other site 768066005933 AMP binding site [chemical binding]; other site 768066005934 histidine decarboxylase; Provisional; Region: PRK02769 768066005935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768066005936 catalytic residue [active] 768066005937 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 768066005938 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066005939 N-terminal plug; other site 768066005940 ligand-binding site [chemical binding]; other site 768066005941 Condensation domain; Region: Condensation; pfam00668 768066005942 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768066005943 Condensation domain; Region: Condensation; pfam00668 768066005944 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 768066005945 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 768066005946 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 768066005947 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768066005948 putative ligand binding residues [chemical binding]; other site 768066005949 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 768066005950 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768066005951 Walker A/P-loop; other site 768066005952 ATP binding site [chemical binding]; other site 768066005953 Q-loop/lid; other site 768066005954 ABC transporter signature motif; other site 768066005955 Walker B; other site 768066005956 D-loop; other site 768066005957 H-loop/switch region; other site 768066005958 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066005959 ABC-ATPase subunit interface; other site 768066005960 dimer interface [polypeptide binding]; other site 768066005961 putative PBP binding regions; other site 768066005962 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768066005963 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066005964 ABC-ATPase subunit interface; other site 768066005965 dimer interface [polypeptide binding]; other site 768066005966 putative PBP binding regions; other site 768066005967 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768066005968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066005969 Walker A/P-loop; other site 768066005970 ATP binding site [chemical binding]; other site 768066005971 Q-loop/lid; other site 768066005972 ABC transporter signature motif; other site 768066005973 Walker B; other site 768066005974 D-loop; other site 768066005975 H-loop/switch region; other site 768066005976 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768066005977 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768066005978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066005979 Walker A/P-loop; other site 768066005980 ATP binding site [chemical binding]; other site 768066005981 Q-loop/lid; other site 768066005982 ABC transporter signature motif; other site 768066005983 Walker B; other site 768066005984 D-loop; other site 768066005985 H-loop/switch region; other site 768066005986 isochorismate synthase DhbC; Validated; Region: PRK06923 768066005987 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768066005988 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 768066005989 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 768066005990 acyl-activating enzyme (AAE) consensus motif; other site 768066005991 active site 768066005992 AMP binding site [chemical binding]; other site 768066005993 substrate binding site [chemical binding]; other site 768066005994 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 768066005995 Isochorismatase family; Region: Isochorismatase; pfam00857 768066005996 catalytic triad [active] 768066005997 conserved cis-peptide bond; other site 768066005998 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 768066005999 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 768066006000 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 768066006001 putative NAD(P) binding site [chemical binding]; other site 768066006002 active site 768066006003 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 768066006004 homotrimer interaction site [polypeptide binding]; other site 768066006005 putative active site [active] 768066006006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066006007 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768066006008 dimerization interface [polypeptide binding]; other site 768066006009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066006010 dimer interface [polypeptide binding]; other site 768066006011 phosphorylation site [posttranslational modification] 768066006012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066006013 ATP binding site [chemical binding]; other site 768066006014 Mg2+ binding site [ion binding]; other site 768066006015 G-X-G motif; other site 768066006016 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768066006017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066006018 active site 768066006019 phosphorylation site [posttranslational modification] 768066006020 intermolecular recognition site; other site 768066006021 dimerization interface [polypeptide binding]; other site 768066006022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066006023 DNA binding site [nucleotide binding] 768066006024 MltA-interacting protein MipA; Region: MipA; cl01504 768066006025 benzoate transport; Region: 2A0115; TIGR00895 768066006026 short chain dehydrogenase; Provisional; Region: PRK06482 768066006027 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768066006028 NADP binding site [chemical binding]; other site 768066006029 active site 768066006030 steroid binding site; other site 768066006031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066006032 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066006033 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 768066006034 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 768066006035 acyl-activating enzyme (AAE) consensus motif; other site 768066006036 AMP binding site [chemical binding]; other site 768066006037 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768066006038 thioester reductase domain; Region: Thioester-redct; TIGR01746 768066006039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066006040 NAD(P) binding site [chemical binding]; other site 768066006041 active site 768066006042 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 768066006043 NnrS protein; Region: NnrS; pfam05940 768066006044 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 768066006045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066006046 FeS/SAM binding site; other site 768066006047 HemN C-terminal domain; Region: HemN_C; pfam06969 768066006048 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 768066006049 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768066006050 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 768066006051 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 768066006052 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 768066006053 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 768066006054 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 768066006055 [4Fe-4S] binding site [ion binding]; other site 768066006056 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768066006057 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768066006058 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768066006059 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 768066006060 molybdopterin cofactor binding site; other site 768066006061 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 768066006062 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 768066006063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768066006064 dimerization interface [polypeptide binding]; other site 768066006065 Histidine kinase; Region: HisKA_3; pfam07730 768066006066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066006067 ATP binding site [chemical binding]; other site 768066006068 Mg2+ binding site [ion binding]; other site 768066006069 G-X-G motif; other site 768066006070 transcriptional regulator NarL; Provisional; Region: PRK10651 768066006071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066006072 active site 768066006073 phosphorylation site [posttranslational modification] 768066006074 intermolecular recognition site; other site 768066006075 dimerization interface [polypeptide binding]; other site 768066006076 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768066006077 DNA binding residues [nucleotide binding] 768066006078 dimerization interface [polypeptide binding]; other site 768066006079 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 768066006080 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 768066006081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066006082 putative substrate translocation pore; other site 768066006083 Hint domain; Region: Hint_2; pfam13403 768066006084 Predicted membrane protein [Function unknown]; Region: COG1289 768066006085 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768066006086 L-aspartate oxidase; Provisional; Region: PRK09077 768066006087 L-aspartate oxidase; Provisional; Region: PRK06175 768066006088 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768066006089 Uncharacterized conserved protein [Function unknown]; Region: COG2938 768066006090 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768066006091 IHF - DNA interface [nucleotide binding]; other site 768066006092 IHF dimer interface [polypeptide binding]; other site 768066006093 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 768066006094 tetratricopeptide repeat protein; Provisional; Region: PRK11788 768066006095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768066006096 TPR motif; other site 768066006097 binding surface 768066006098 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 768066006099 active site 768066006100 dimer interface [polypeptide binding]; other site 768066006101 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 768066006102 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 768066006103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066006104 NAD(P) binding site [chemical binding]; other site 768066006105 active site 768066006106 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 768066006107 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 768066006108 oligomerisation interface [polypeptide binding]; other site 768066006109 mobile loop; other site 768066006110 roof hairpin; other site 768066006111 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 768066006112 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 768066006113 ring oligomerisation interface [polypeptide binding]; other site 768066006114 ATP/Mg binding site [chemical binding]; other site 768066006115 stacking interactions; other site 768066006116 hinge regions; other site 768066006117 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 768066006118 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768066006119 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 768066006120 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 768066006121 homodimer interface [polypeptide binding]; other site 768066006122 substrate-cofactor binding pocket; other site 768066006123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066006124 catalytic residue [active] 768066006125 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 768066006126 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 768066006127 active site 768066006128 Zn binding site [ion binding]; other site 768066006129 ornithine cyclodeaminase; Validated; Region: PRK06141 768066006130 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 768066006131 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 768066006132 homotrimer interaction site [polypeptide binding]; other site 768066006133 putative active site [active] 768066006134 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 768066006135 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 768066006136 active site 768066006137 Zn binding site [ion binding]; other site 768066006138 DctM-like transporters; Region: DctM; pfam06808 768066006139 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066006140 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066006141 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066006142 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066006143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066006144 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768066006145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066006146 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768066006147 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 768066006148 NAD(P) binding site [chemical binding]; other site 768066006149 Proline racemase; Region: Pro_racemase; pfam05544 768066006150 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768066006151 Cupin domain; Region: Cupin_2; pfam07883 768066006152 Cupin domain; Region: Cupin_2; pfam07883 768066006153 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 768066006154 Carboxylesterase family; Region: COesterase; pfam00135 768066006155 substrate binding pocket [chemical binding]; other site 768066006156 catalytic triad [active] 768066006157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066006158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066006159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768066006160 dimerization interface [polypeptide binding]; other site 768066006161 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 768066006162 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 768066006163 active site 768066006164 nucleophile elbow; other site 768066006165 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 768066006166 GAF domain; Region: GAF; cl17456 768066006167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066006168 Walker A motif; other site 768066006169 ATP binding site [chemical binding]; other site 768066006170 Walker B motif; other site 768066006171 arginine finger; other site 768066006172 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 768066006173 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 768066006174 heme-binding site [chemical binding]; other site 768066006175 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 768066006176 FAD binding pocket [chemical binding]; other site 768066006177 FAD binding motif [chemical binding]; other site 768066006178 phosphate binding motif [ion binding]; other site 768066006179 beta-alpha-beta structure motif; other site 768066006180 NAD binding pocket [chemical binding]; other site 768066006181 Heme binding pocket [chemical binding]; other site 768066006182 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 768066006183 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 768066006184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066006185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066006186 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 768066006187 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 768066006188 putative NAD(P) binding site [chemical binding]; other site 768066006189 putative substrate binding site [chemical binding]; other site 768066006190 catalytic Zn binding site [ion binding]; other site 768066006191 structural Zn binding site [ion binding]; other site 768066006192 dimer interface [polypeptide binding]; other site 768066006193 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768066006194 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 768066006195 Walker A/P-loop; other site 768066006196 ATP binding site [chemical binding]; other site 768066006197 Q-loop/lid; other site 768066006198 ABC transporter signature motif; other site 768066006199 Walker B; other site 768066006200 D-loop; other site 768066006201 H-loop/switch region; other site 768066006202 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768066006203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066006204 dimer interface [polypeptide binding]; other site 768066006205 conserved gate region; other site 768066006206 putative PBP binding loops; other site 768066006207 ABC-ATPase subunit interface; other site 768066006208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066006209 dimer interface [polypeptide binding]; other site 768066006210 conserved gate region; other site 768066006211 putative PBP binding loops; other site 768066006212 ABC-ATPase subunit interface; other site 768066006213 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 768066006214 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 768066006215 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768066006216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066006217 DNA-binding site [nucleotide binding]; DNA binding site 768066006218 transcriptional regulator protein; Region: phnR; TIGR03337 768066006219 UTRA domain; Region: UTRA; pfam07702 768066006220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066006221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066006222 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768066006223 putative effector binding pocket; other site 768066006224 putative dimerization interface [polypeptide binding]; other site 768066006225 short chain dehydrogenase; Provisional; Region: PRK12937 768066006226 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 768066006227 NADP binding site [chemical binding]; other site 768066006228 homodimer interface [polypeptide binding]; other site 768066006229 active site 768066006230 substrate binding site [chemical binding]; other site 768066006231 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 768066006232 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 768066006233 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 768066006234 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 768066006235 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 768066006236 PAAR motif; Region: PAAR_motif; pfam05488 768066006237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066006238 Coenzyme A binding pocket [chemical binding]; other site 768066006239 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 768066006240 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 768066006241 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 768066006242 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 768066006243 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 768066006244 Protein of unknown function (DUF3121); Region: DUF3121; pfam11319 768066006245 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 768066006246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066006247 Walker A motif; other site 768066006248 ATP binding site [chemical binding]; other site 768066006249 Walker B motif; other site 768066006250 arginine finger; other site 768066006251 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768066006252 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 768066006253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066006254 Walker A motif; other site 768066006255 ATP binding site [chemical binding]; other site 768066006256 Walker B motif; other site 768066006257 arginine finger; other site 768066006258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066006259 Walker A motif; other site 768066006260 ATP binding site [chemical binding]; other site 768066006261 Walker B motif; other site 768066006262 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768066006263 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 768066006264 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 768066006265 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 768066006266 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 768066006267 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 768066006268 FHA domain; Region: FHA; pfam00498 768066006269 phosphopeptide binding site; other site 768066006270 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 768066006271 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 768066006272 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 768066006273 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 768066006274 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 768066006275 Protein of unknown function (DUF877); Region: DUF877; pfam05943 768066006276 Protein of unknown function (DUF770); Region: DUF770; pfam05591 768066006277 Uncharacterized conserved protein [Function unknown]; Region: COG1284 768066006278 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 768066006279 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 768066006280 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 768066006281 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 768066006282 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 768066006283 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 768066006284 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 768066006285 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 768066006286 isovaleryl-CoA dehydrogenase; Region: PLN02519 768066006287 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 768066006288 substrate binding site [chemical binding]; other site 768066006289 FAD binding site [chemical binding]; other site 768066006290 catalytic base [active] 768066006291 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 768066006292 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 768066006293 enoyl-CoA hydratase; Provisional; Region: PRK05995 768066006294 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768066006295 substrate binding site [chemical binding]; other site 768066006296 oxyanion hole (OAH) forming residues; other site 768066006297 trimer interface [polypeptide binding]; other site 768066006298 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 768066006299 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768066006300 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768066006301 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768066006302 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768066006303 carboxyltransferase (CT) interaction site; other site 768066006304 biotinylation site [posttranslational modification]; other site 768066006305 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 768066006306 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 768066006307 active site 768066006308 catalytic residues [active] 768066006309 metal binding site [ion binding]; metal-binding site 768066006310 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066006311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066006312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066006313 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066006314 DctM-like transporters; Region: DctM; pfam06808 768066006315 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768066006316 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 768066006317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768066006318 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 768066006319 active site 768066006320 YcaO domain protein; Region: TIGR03549 768066006321 OsmC-like protein; Region: OsmC; pfam02566 768066006322 YcaO-like family; Region: YcaO; pfam02624 768066006323 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 768066006324 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 768066006325 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 768066006326 DAK2 domain; Region: Dak2; pfam02734 768066006327 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768066006328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066006329 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 768066006330 Coenzyme A binding pocket [chemical binding]; other site 768066006331 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 768066006332 Na binding site [ion binding]; other site 768066006333 amidase; Provisional; Region: PRK07042 768066006334 Amidase; Region: Amidase; cl11426 768066006335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066006336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066006337 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066006338 dimerization interface [polypeptide binding]; other site 768066006339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768066006340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066006341 Coenzyme A binding pocket [chemical binding]; other site 768066006342 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066006343 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 768066006344 conserved cys residue [active] 768066006345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066006346 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768066006347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066006348 S-adenosylmethionine binding site [chemical binding]; other site 768066006349 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768066006350 dimer interface [polypeptide binding]; other site 768066006351 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 768066006352 Cation efflux family; Region: Cation_efflux; cl00316 768066006353 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768066006354 homotrimer interaction site [polypeptide binding]; other site 768066006355 putative active site [active] 768066006356 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768066006357 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768066006358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066006359 DNA-binding site [nucleotide binding]; DNA binding site 768066006360 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066006361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066006362 homodimer interface [polypeptide binding]; other site 768066006363 catalytic residue [active] 768066006364 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768066006365 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768066006366 Cl- selectivity filter; other site 768066006367 Cl- binding residues [ion binding]; other site 768066006368 pore gating glutamate residue; other site 768066006369 dimer interface [polypeptide binding]; other site 768066006370 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 768066006371 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 768066006372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768066006373 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 768066006374 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 768066006375 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 768066006376 NADP binding site [chemical binding]; other site 768066006377 homodimer interface [polypeptide binding]; other site 768066006378 active site 768066006379 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 768066006380 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768066006381 Bacterial transcriptional regulator; Region: IclR; pfam01614 768066006382 DctM-like transporters; Region: DctM; pfam06808 768066006383 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066006384 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 768066006385 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 768066006386 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 768066006387 Metal-binding active site; metal-binding site 768066006388 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 768066006389 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 768066006390 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 768066006391 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 768066006392 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 768066006393 Walker A motif; other site 768066006394 ATP binding site [chemical binding]; other site 768066006395 Walker B motif; other site 768066006396 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 768066006397 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768066006398 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768066006399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066006400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066006401 LexA repressor; Validated; Region: PRK00215 768066006402 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 768066006403 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768066006404 Catalytic site [active] 768066006405 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 768066006406 active site 768066006407 DNA polymerase IV; Validated; Region: PRK02406 768066006408 DNA binding site [nucleotide binding] 768066006409 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 768066006410 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 768066006411 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 768066006412 putative active site [active] 768066006413 putative substrate binding site [chemical binding]; other site 768066006414 putative cosubstrate binding site; other site 768066006415 catalytic site [active] 768066006416 conserved hypothetical protein; Region: MG423; TIGR00649 768066006417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768066006418 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768066006419 AT hook motif; Region: AT_hook; pfam02178 768066006420 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 768066006421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066006422 FeS/SAM binding site; other site 768066006423 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768066006424 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 768066006425 MoaE homodimer interface [polypeptide binding]; other site 768066006426 MoaD interaction [polypeptide binding]; other site 768066006427 active site residues [active] 768066006428 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 768066006429 trimer interface [polypeptide binding]; other site 768066006430 dimer interface [polypeptide binding]; other site 768066006431 putative active site [active] 768066006432 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 768066006433 MoaE interaction surface [polypeptide binding]; other site 768066006434 MoeB interaction surface [polypeptide binding]; other site 768066006435 thiocarboxylated glycine; other site 768066006436 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 768066006437 Walker A motif; other site 768066006438 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 768066006439 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 768066006440 GTP binding site; other site 768066006441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066006442 sequence-specific DNA binding site [nucleotide binding]; other site 768066006443 salt bridge; other site 768066006444 Cupin domain; Region: Cupin_2; pfam07883 768066006445 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 768066006446 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 768066006447 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768066006448 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768066006449 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768066006450 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 768066006451 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768066006452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066006453 dimer interface [polypeptide binding]; other site 768066006454 conserved gate region; other site 768066006455 putative PBP binding loops; other site 768066006456 ABC-ATPase subunit interface; other site 768066006457 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768066006458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066006459 putative PBP binding loops; other site 768066006460 dimer interface [polypeptide binding]; other site 768066006461 ABC-ATPase subunit interface; other site 768066006462 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 768066006463 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 768066006464 Walker A/P-loop; other site 768066006465 ATP binding site [chemical binding]; other site 768066006466 Q-loop/lid; other site 768066006467 ABC transporter signature motif; other site 768066006468 Walker B; other site 768066006469 D-loop; other site 768066006470 H-loop/switch region; other site 768066006471 TOBE domain; Region: TOBE_2; pfam08402 768066006472 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 768066006473 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 768066006474 Walker A/P-loop; other site 768066006475 ATP binding site [chemical binding]; other site 768066006476 Q-loop/lid; other site 768066006477 ABC transporter signature motif; other site 768066006478 Walker B; other site 768066006479 D-loop; other site 768066006480 H-loop/switch region; other site 768066006481 TOBE domain; Region: TOBE_2; pfam08402 768066006482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768066006483 active site 768066006484 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 768066006485 ligand binding site [chemical binding]; other site 768066006486 active site 768066006487 UGI interface [polypeptide binding]; other site 768066006488 catalytic site [active] 768066006489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768066006490 active site 768066006491 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768066006492 active site 768066006493 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 768066006494 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 768066006495 Lumazine binding domain; Region: Lum_binding; pfam00677 768066006496 Lumazine binding domain; Region: Lum_binding; pfam00677 768066006497 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 768066006498 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 768066006499 Walker A/P-loop; other site 768066006500 ATP binding site [chemical binding]; other site 768066006501 Q-loop/lid; other site 768066006502 ABC transporter signature motif; other site 768066006503 Walker B; other site 768066006504 D-loop; other site 768066006505 H-loop/switch region; other site 768066006506 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 768066006507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066006508 dimer interface [polypeptide binding]; other site 768066006509 conserved gate region; other site 768066006510 ABC-ATPase subunit interface; other site 768066006511 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 768066006512 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 768066006513 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 768066006514 GAF domain; Region: GAF_2; pfam13185 768066006515 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 768066006516 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 768066006517 N- and C-terminal domain interface [polypeptide binding]; other site 768066006518 active site 768066006519 MgATP binding site [chemical binding]; other site 768066006520 catalytic site [active] 768066006521 metal binding site [ion binding]; metal-binding site 768066006522 glycerol binding site [chemical binding]; other site 768066006523 homotetramer interface [polypeptide binding]; other site 768066006524 homodimer interface [polypeptide binding]; other site 768066006525 FBP binding site [chemical binding]; other site 768066006526 protein IIAGlc interface [polypeptide binding]; other site 768066006527 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 768066006528 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 768066006529 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768066006530 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 768066006531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768066006532 catalytic core [active] 768066006533 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 768066006534 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 768066006535 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 768066006536 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 768066006537 Walker A/P-loop; other site 768066006538 ATP binding site [chemical binding]; other site 768066006539 Q-loop/lid; other site 768066006540 ABC transporter signature motif; other site 768066006541 Walker B; other site 768066006542 D-loop; other site 768066006543 H-loop/switch region; other site 768066006544 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768066006545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066006546 dimer interface [polypeptide binding]; other site 768066006547 conserved gate region; other site 768066006548 ABC-ATPase subunit interface; other site 768066006549 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768066006550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066006551 dimer interface [polypeptide binding]; other site 768066006552 conserved gate region; other site 768066006553 ABC-ATPase subunit interface; other site 768066006554 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768066006555 putative catalytic site [active] 768066006556 putative metal binding site [ion binding]; other site 768066006557 putative phosphate binding site [ion binding]; other site 768066006558 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 768066006559 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 768066006560 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 768066006561 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 768066006562 homodimer interface [polypeptide binding]; other site 768066006563 metal binding site [ion binding]; metal-binding site 768066006564 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 768066006565 homodimer interface [polypeptide binding]; other site 768066006566 active site 768066006567 putative chemical substrate binding site [chemical binding]; other site 768066006568 metal binding site [ion binding]; metal-binding site 768066006569 HD domain; Region: HD_4; pfam13328 768066006570 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768066006571 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768066006572 synthetase active site [active] 768066006573 NTP binding site [chemical binding]; other site 768066006574 metal binding site [ion binding]; metal-binding site 768066006575 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768066006576 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768066006577 TRAM domain; Region: TRAM; pfam01938 768066006578 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 768066006579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066006580 S-adenosylmethionine binding site [chemical binding]; other site 768066006581 cysteine synthase B; Region: cysM; TIGR01138 768066006582 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768066006583 dimer interface [polypeptide binding]; other site 768066006584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066006585 catalytic residue [active] 768066006586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066006587 dimer interface [polypeptide binding]; other site 768066006588 phosphorylation site [posttranslational modification] 768066006589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066006590 ATP binding site [chemical binding]; other site 768066006591 Mg2+ binding site [ion binding]; other site 768066006592 G-X-G motif; other site 768066006593 Response regulator receiver domain; Region: Response_reg; pfam00072 768066006594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066006595 active site 768066006596 phosphorylation site [posttranslational modification] 768066006597 intermolecular recognition site; other site 768066006598 dimerization interface [polypeptide binding]; other site 768066006599 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768066006600 putative binding surface; other site 768066006601 active site 768066006602 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 768066006603 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 768066006604 active site 768066006605 hydrophilic channel; other site 768066006606 dimerization interface [polypeptide binding]; other site 768066006607 catalytic residues [active] 768066006608 active site lid [active] 768066006609 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 768066006610 Recombination protein O N terminal; Region: RecO_N; pfam11967 768066006611 Recombination protein O C terminal; Region: RecO_C; pfam02565 768066006612 GTPase Era; Reviewed; Region: era; PRK00089 768066006613 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 768066006614 G1 box; other site 768066006615 GTP/Mg2+ binding site [chemical binding]; other site 768066006616 Switch I region; other site 768066006617 G2 box; other site 768066006618 Switch II region; other site 768066006619 G3 box; other site 768066006620 G4 box; other site 768066006621 G5 box; other site 768066006622 KH domain; Region: KH_2; pfam07650 768066006623 ribonuclease III; Reviewed; Region: rnc; PRK00102 768066006624 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 768066006625 dimerization interface [polypeptide binding]; other site 768066006626 active site 768066006627 metal binding site [ion binding]; metal-binding site 768066006628 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 768066006629 dsRNA binding site [nucleotide binding]; other site 768066006630 signal peptidase I; Provisional; Region: PRK10861 768066006631 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768066006632 Catalytic site [active] 768066006633 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768066006634 Catalytic site [active] 768066006635 GTP-binding protein LepA; Provisional; Region: PRK05433 768066006636 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 768066006637 G1 box; other site 768066006638 putative GEF interaction site [polypeptide binding]; other site 768066006639 GTP/Mg2+ binding site [chemical binding]; other site 768066006640 Switch I region; other site 768066006641 G2 box; other site 768066006642 G3 box; other site 768066006643 Switch II region; other site 768066006644 G4 box; other site 768066006645 G5 box; other site 768066006646 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 768066006647 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 768066006648 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 768066006649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 768066006650 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 768066006651 Protein of unknown function (DUF2501); Region: DUF2501; cl08197 768066006652 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 768066006653 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768066006654 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768066006655 protein binding site [polypeptide binding]; other site 768066006656 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768066006657 protein binding site [polypeptide binding]; other site 768066006658 MucB/RseB family; Region: MucB_RseB; pfam03888 768066006659 anti-sigma E factor; Provisional; Region: rseB; PRK09455 768066006660 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 768066006661 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 768066006662 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768066006663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768066006664 DNA binding residues [nucleotide binding] 768066006665 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 768066006666 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768066006667 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 768066006668 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 768066006669 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768066006670 helicase 45; Provisional; Region: PTZ00424 768066006671 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768066006672 ATP binding site [chemical binding]; other site 768066006673 Mg++ binding site [ion binding]; other site 768066006674 motif III; other site 768066006675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066006676 nucleotide binding region [chemical binding]; other site 768066006677 ATP-binding site [chemical binding]; other site 768066006678 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 768066006679 putative catalytic site [active] 768066006680 putative phosphate binding site [ion binding]; other site 768066006681 active site 768066006682 metal binding site A [ion binding]; metal-binding site 768066006683 DNA binding site [nucleotide binding] 768066006684 putative AP binding site [nucleotide binding]; other site 768066006685 putative metal binding site B [ion binding]; other site 768066006686 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 768066006687 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 768066006688 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768066006689 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 768066006690 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 768066006691 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 768066006692 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 768066006693 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 768066006694 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 768066006695 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 768066006696 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 768066006697 Ligand binding site [chemical binding]; other site 768066006698 Electron transfer flavoprotein domain; Region: ETF; pfam01012 768066006699 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 768066006700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768066006701 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 768066006702 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 768066006703 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 768066006704 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 768066006705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768066006706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066006707 S-adenosylmethionine binding site [chemical binding]; other site 768066006708 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 768066006709 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 768066006710 quinone interaction residues [chemical binding]; other site 768066006711 active site 768066006712 catalytic residues [active] 768066006713 FMN binding site [chemical binding]; other site 768066006714 substrate binding site [chemical binding]; other site 768066006715 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 768066006716 MgtE intracellular N domain; Region: MgtE_N; smart00924 768066006717 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768066006718 Divalent cation transporter; Region: MgtE; cl00786 768066006719 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 768066006720 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 768066006721 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 768066006722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066006723 S-adenosylmethionine binding site [chemical binding]; other site 768066006724 glutamate racemase; Provisional; Region: PRK00865 768066006725 Hemerythrin family; Region: Hemerythrin-like; cl15774 768066006726 recombination factor protein RarA; Reviewed; Region: PRK13342 768066006727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066006728 Walker A motif; other site 768066006729 ATP binding site [chemical binding]; other site 768066006730 Walker B motif; other site 768066006731 arginine finger; other site 768066006732 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 768066006733 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768066006734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066006735 DNA-binding site [nucleotide binding]; DNA binding site 768066006736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066006737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066006738 homodimer interface [polypeptide binding]; other site 768066006739 catalytic residue [active] 768066006740 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 768066006741 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 768066006742 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 768066006743 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768066006744 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 768066006745 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 768066006746 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 768066006747 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 768066006748 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 768066006749 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 768066006750 rRNA binding site [nucleotide binding]; other site 768066006751 predicted 30S ribosome binding site; other site 768066006752 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 768066006753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066006754 Walker A motif; other site 768066006755 ATP binding site [chemical binding]; other site 768066006756 Walker B motif; other site 768066006757 arginine finger; other site 768066006758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066006759 Walker A motif; other site 768066006760 ATP binding site [chemical binding]; other site 768066006761 Walker B motif; other site 768066006762 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768066006763 Uncharacterized conserved protein [Function unknown]; Region: COG2127 768066006764 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 768066006765 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 768066006766 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 768066006767 active site 768066006768 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 768066006769 nudix motif; other site 768066006770 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 768066006771 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 768066006772 Protein of unknown function (DUF489); Region: DUF489; pfam04356 768066006773 adenylosuccinate lyase; Provisional; Region: PRK09285 768066006774 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 768066006775 tetramer interface [polypeptide binding]; other site 768066006776 active site 768066006777 Uncharacterized conserved protein [Function unknown]; Region: COG2850 768066006778 Cupin-like domain; Region: Cupin_8; pfam13621 768066006779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768066006780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066006781 Coenzyme A binding pocket [chemical binding]; other site 768066006782 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 768066006783 tetramer interface [polypeptide binding]; other site 768066006784 isocitrate lyase; Provisional; Region: PRK15063 768066006785 active site 768066006786 Mg2+/Mn2+ binding site [ion binding]; other site 768066006787 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 768066006788 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 768066006789 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768066006790 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 768066006791 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 768066006792 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768066006793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066006794 putative substrate translocation pore; other site 768066006795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066006796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066006797 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768066006798 dimerization interface [polypeptide binding]; other site 768066006799 NlpC/P60 family; Region: NLPC_P60; pfam00877 768066006800 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 768066006801 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 768066006802 succinic semialdehyde dehydrogenase; Region: PLN02278 768066006803 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768066006804 tetramerization interface [polypeptide binding]; other site 768066006805 NAD(P) binding site [chemical binding]; other site 768066006806 catalytic residues [active] 768066006807 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 768066006808 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066006809 inhibitor-cofactor binding pocket; inhibition site 768066006810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066006811 catalytic residue [active] 768066006812 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 768066006813 putative transporter; Provisional; Region: PRK10484 768066006814 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 768066006815 Na binding site [ion binding]; other site 768066006816 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066006817 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 768066006818 conserved cys residue [active] 768066006819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066006820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066006821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768066006822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066006823 putative substrate translocation pore; other site 768066006824 YcjX-like family, DUF463; Region: DUF463; pfam04317 768066006825 hypothetical protein; Provisional; Region: PRK05415 768066006826 Domain of unknown function (DUF697); Region: DUF697; pfam05128 768066006827 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 768066006828 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 768066006829 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768066006830 Walker A/P-loop; other site 768066006831 ATP binding site [chemical binding]; other site 768066006832 Q-loop/lid; other site 768066006833 ABC transporter signature motif; other site 768066006834 Walker B; other site 768066006835 D-loop; other site 768066006836 H-loop/switch region; other site 768066006837 TOBE domain; Region: TOBE_2; pfam08402 768066006838 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768066006839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066006840 dimer interface [polypeptide binding]; other site 768066006841 conserved gate region; other site 768066006842 putative PBP binding loops; other site 768066006843 ABC-ATPase subunit interface; other site 768066006844 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 768066006845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066006846 putative PBP binding loops; other site 768066006847 dimer interface [polypeptide binding]; other site 768066006848 ABC-ATPase subunit interface; other site 768066006849 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 768066006850 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768066006851 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 768066006852 dimerization interface [polypeptide binding]; other site 768066006853 putative active cleft [active] 768066006854 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 768066006855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066006856 dimer interface [polypeptide binding]; other site 768066006857 phosphorylation site [posttranslational modification] 768066006858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066006859 ATP binding site [chemical binding]; other site 768066006860 Mg2+ binding site [ion binding]; other site 768066006861 G-X-G motif; other site 768066006862 osmolarity response regulator; Provisional; Region: ompR; PRK09468 768066006863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066006864 active site 768066006865 phosphorylation site [posttranslational modification] 768066006866 intermolecular recognition site; other site 768066006867 dimerization interface [polypeptide binding]; other site 768066006868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066006869 DNA binding site [nucleotide binding] 768066006870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066006871 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 768066006872 active site 768066006873 motif I; other site 768066006874 motif II; other site 768066006875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066006876 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 768066006877 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 768066006878 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 768066006879 active site turn [active] 768066006880 phosphorylation site [posttranslational modification] 768066006881 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 768066006882 active site turn [active] 768066006883 phosphorylation site [posttranslational modification] 768066006884 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 768066006885 HPr interaction site; other site 768066006886 glycerol kinase (GK) interaction site [polypeptide binding]; other site 768066006887 active site 768066006888 phosphorylation site [posttranslational modification] 768066006889 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768066006890 dimerization domain swap beta strand [polypeptide binding]; other site 768066006891 regulatory protein interface [polypeptide binding]; other site 768066006892 active site 768066006893 regulatory phosphorylation site [posttranslational modification]; other site 768066006894 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768066006895 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 768066006896 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768066006897 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768066006898 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 768066006899 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768066006900 dimer interface [polypeptide binding]; other site 768066006901 active site 768066006902 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768066006903 dimer interface [polypeptide binding]; other site 768066006904 active site 768066006905 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 768066006906 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 768066006907 active site 768066006908 dimer interface [polypeptide binding]; other site 768066006909 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768066006910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066006911 DNA-binding site [nucleotide binding]; DNA binding site 768066006912 UTRA domain; Region: UTRA; pfam07702 768066006913 exoribonuclease II; Provisional; Region: PRK05054 768066006914 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768066006915 RNB domain; Region: RNB; pfam00773 768066006916 S1 RNA binding domain; Region: S1; pfam00575 768066006917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768066006918 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 768066006919 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768066006920 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 768066006921 Na binding site [ion binding]; other site 768066006922 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 768066006923 CoA binding domain; Region: CoA_binding; pfam02629 768066006924 CoA-ligase; Region: Ligase_CoA; pfam00549 768066006925 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 768066006926 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 768066006927 CoA-ligase; Region: Ligase_CoA; pfam00549 768066006928 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 768066006929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066006930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066006931 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768066006932 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768066006933 E3 interaction surface; other site 768066006934 lipoyl attachment site [posttranslational modification]; other site 768066006935 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 768066006936 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768066006937 E3 interaction surface; other site 768066006938 lipoyl attachment site [posttranslational modification]; other site 768066006939 e3 binding domain; Region: E3_binding; pfam02817 768066006940 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768066006941 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 768066006942 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 768066006943 TPP-binding site [chemical binding]; other site 768066006944 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 768066006945 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 768066006946 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768066006947 L-aspartate oxidase; Provisional; Region: PRK06175 768066006948 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05675 768066006949 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768066006950 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 768066006951 SdhC subunit interface [polypeptide binding]; other site 768066006952 proximal heme binding site [chemical binding]; other site 768066006953 cardiolipin binding site; other site 768066006954 Iron-sulfur protein interface; other site 768066006955 proximal quinone binding site [chemical binding]; other site 768066006956 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 768066006957 Iron-sulfur protein interface; other site 768066006958 proximal quinone binding site [chemical binding]; other site 768066006959 SdhD (CybS) interface [polypeptide binding]; other site 768066006960 proximal heme binding site [chemical binding]; other site 768066006961 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 768066006962 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 768066006963 dimer interface [polypeptide binding]; other site 768066006964 active site 768066006965 citrylCoA binding site [chemical binding]; other site 768066006966 NADH binding [chemical binding]; other site 768066006967 cationic pore residues; other site 768066006968 oxalacetate/citrate binding site [chemical binding]; other site 768066006969 coenzyme A binding site [chemical binding]; other site 768066006970 catalytic triad [active] 768066006971 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 768066006972 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 768066006973 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 768066006974 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768066006975 active site 768066006976 HIGH motif; other site 768066006977 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768066006978 active site 768066006979 KMSKS motif; other site 768066006980 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768066006981 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 768066006982 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768066006983 FMN binding site [chemical binding]; other site 768066006984 active site 768066006985 catalytic residues [active] 768066006986 substrate binding site [chemical binding]; other site 768066006987 Predicted deacylase [General function prediction only]; Region: COG3608 768066006988 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 768066006989 putative active site [active] 768066006990 Zn binding site [ion binding]; other site 768066006991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066006992 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 768066006993 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768066006994 Protein export membrane protein; Region: SecD_SecF; cl14618 768066006995 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768066006996 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768066006997 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066006998 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 768066006999 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768066007000 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768066007001 Phosphotransferase enzyme family; Region: APH; pfam01636 768066007002 Fructosamine kinase; Region: Fructosamin_kin; cl17579 768066007003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 768066007004 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 768066007005 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 768066007006 nudix motif; other site 768066007007 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 768066007008 putative active site [active] 768066007009 putative CoA binding site [chemical binding]; other site 768066007010 nudix motif; other site 768066007011 metal binding site [ion binding]; metal-binding site 768066007012 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 768066007013 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 768066007014 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 768066007015 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 768066007016 MOSC domain; Region: MOSC; pfam03473 768066007017 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 768066007018 aspartate racemase; Region: asp_race; TIGR00035 768066007019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066007020 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768066007021 Coenzyme A binding pocket [chemical binding]; other site 768066007022 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 768066007023 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768066007024 substrate binding site [chemical binding]; other site 768066007025 oxyanion hole (OAH) forming residues; other site 768066007026 trimer interface [polypeptide binding]; other site 768066007027 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768066007028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768066007029 active site 768066007030 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 768066007031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066007032 putative substrate translocation pore; other site 768066007033 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768066007034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768066007035 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 768066007036 dimer interface [polypeptide binding]; other site 768066007037 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066007038 metal binding site [ion binding]; metal-binding site 768066007039 Predicted membrane protein [Function unknown]; Region: COG3671 768066007040 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768066007041 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 768066007042 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768066007043 putative acyl-acceptor binding pocket; other site 768066007044 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 768066007045 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 768066007046 glucosyltransferase MdoH; Provisional; Region: PRK05454 768066007047 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768066007048 active site 768066007049 Putative transcription activator [Transcription]; Region: TenA; COG0819 768066007050 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 768066007051 ThiC-associated domain; Region: ThiC-associated; pfam13667 768066007052 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 768066007053 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 768066007054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768066007055 catalytic residue [active] 768066007056 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 768066007057 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 768066007058 UbiA prenyltransferase family; Region: UbiA; pfam01040 768066007059 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 768066007060 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 768066007061 Subunit I/III interface [polypeptide binding]; other site 768066007062 Subunit III/IV interface [polypeptide binding]; other site 768066007063 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 768066007064 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 768066007065 D-pathway; other site 768066007066 Putative ubiquinol binding site [chemical binding]; other site 768066007067 Low-spin heme (heme b) binding site [chemical binding]; other site 768066007068 Putative water exit pathway; other site 768066007069 Binuclear center (heme o3/CuB) [ion binding]; other site 768066007070 K-pathway; other site 768066007071 Putative proton exit pathway; other site 768066007072 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 768066007073 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 768066007074 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 768066007075 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 768066007076 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 768066007077 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 768066007078 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 768066007079 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 768066007080 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 768066007081 Nucleoside recognition; Region: Gate; pfam07670 768066007082 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 768066007083 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 768066007084 intersubunit interface [polypeptide binding]; other site 768066007085 active site 768066007086 catalytic residue [active] 768066007087 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 768066007088 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768066007089 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768066007090 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 768066007091 phosphopentomutase; Provisional; Region: PRK05362 768066007092 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 768066007093 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 768066007094 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 768066007095 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 768066007096 active site 768066007097 catalytic motif [active] 768066007098 Zn binding site [ion binding]; other site 768066007099 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768066007100 putative active site pocket [active] 768066007101 dimerization interface [polypeptide binding]; other site 768066007102 putative catalytic residue [active] 768066007103 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 768066007104 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 768066007105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066007106 Coenzyme A binding pocket [chemical binding]; other site 768066007107 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 768066007108 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768066007109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768066007110 DNA binding site [nucleotide binding] 768066007111 domain linker motif; other site 768066007112 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768066007113 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768066007114 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768066007115 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768066007116 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 768066007117 conserved cys residue [active] 768066007118 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 768066007119 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768066007120 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 768066007121 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 768066007122 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 768066007123 catalytic triad [active] 768066007124 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 768066007125 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768066007126 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768066007127 active site 768066007128 catalytic tetrad [active] 768066007129 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 768066007130 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 768066007131 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768066007132 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 768066007133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066007134 Coenzyme A binding pocket [chemical binding]; other site 768066007135 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768066007136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066007137 DNA-binding site [nucleotide binding]; DNA binding site 768066007138 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066007139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066007140 homodimer interface [polypeptide binding]; other site 768066007141 catalytic residue [active] 768066007142 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 768066007143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066007144 NACHT domain; Region: NACHT; pfam05729 768066007145 Walker A motif; other site 768066007146 ATP binding site [chemical binding]; other site 768066007147 Walker B motif; other site 768066007148 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768066007149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066007150 DNA binding site [nucleotide binding] 768066007151 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 768066007152 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 768066007153 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 768066007154 Active_site [active] 768066007155 exonuclease subunit SbcD; Provisional; Region: PRK10966 768066007156 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 768066007157 active site 768066007158 metal binding site [ion binding]; metal-binding site 768066007159 DNA binding site [nucleotide binding] 768066007160 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 768066007161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066007162 Walker A/P-loop; other site 768066007163 ATP binding site [chemical binding]; other site 768066007164 Q-loop/lid; other site 768066007165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066007166 ABC transporter signature motif; other site 768066007167 Walker B; other site 768066007168 D-loop; other site 768066007169 H-loop/switch region; other site 768066007170 short chain dehydrogenase; Provisional; Region: PRK05993 768066007171 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 768066007172 NADP binding site [chemical binding]; other site 768066007173 active site 768066007174 steroid binding site; other site 768066007175 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768066007176 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 768066007177 FMN binding site [chemical binding]; other site 768066007178 active site 768066007179 substrate binding site [chemical binding]; other site 768066007180 catalytic residue [active] 768066007181 acetylornithine deacetylase; Provisional; Region: PRK07522 768066007182 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 768066007183 metal binding site [ion binding]; metal-binding site 768066007184 putative dimer interface [polypeptide binding]; other site 768066007185 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768066007186 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 768066007187 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768066007188 DEAD-like helicases superfamily; Region: DEXDc; smart00487 768066007189 ATP binding site [chemical binding]; other site 768066007190 Mg++ binding site [ion binding]; other site 768066007191 motif III; other site 768066007192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066007193 nucleotide binding region [chemical binding]; other site 768066007194 ATP-binding site [chemical binding]; other site 768066007195 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 768066007196 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 768066007197 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 768066007198 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 768066007199 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 768066007200 putative dimer interface [polypeptide binding]; other site 768066007201 N-terminal domain interface [polypeptide binding]; other site 768066007202 putative substrate binding pocket (H-site) [chemical binding]; other site 768066007203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066007204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066007205 LysR substrate binding domain; Region: LysR_substrate; pfam03466 768066007206 dimerization interface [polypeptide binding]; other site 768066007207 Pirin-related protein [General function prediction only]; Region: COG1741 768066007208 Pirin; Region: Pirin; pfam02678 768066007209 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 768066007210 putative peptidase; Provisional; Region: PRK11649 768066007211 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768066007212 Peptidase family M23; Region: Peptidase_M23; pfam01551 768066007213 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 768066007214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768066007215 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 768066007216 DNA binding residues [nucleotide binding] 768066007217 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066007218 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 768066007219 dimer interface [polypeptide binding]; other site 768066007220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 768066007221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066007222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066007223 dimerization interface [polypeptide binding]; other site 768066007224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768066007225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768066007226 DNA binding site [nucleotide binding] 768066007227 domain linker motif; other site 768066007228 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 768066007229 dimerization interface [polypeptide binding]; other site 768066007230 ligand binding site [chemical binding]; other site 768066007231 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768066007232 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768066007233 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768066007234 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768066007235 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 768066007236 Metal-binding active site; metal-binding site 768066007237 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 768066007238 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 768066007239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066007240 putative substrate translocation pore; other site 768066007241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066007242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768066007243 putative substrate translocation pore; other site 768066007244 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066007245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066007246 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768066007247 dimerization interface [polypeptide binding]; other site 768066007248 substrate binding pocket [chemical binding]; other site 768066007249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 768066007250 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 768066007251 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768066007252 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 768066007253 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 768066007254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066007255 putative substrate translocation pore; other site 768066007256 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 768066007257 catalytic triad [active] 768066007258 dimer interface [polypeptide binding]; other site 768066007259 Uncharacterized conserved protein [Function unknown]; Region: COG3791 768066007260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066007261 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768066007262 active site 768066007263 putative acetyltransferase; Provisional; Region: PRK03624 768066007264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066007265 Coenzyme A binding pocket [chemical binding]; other site 768066007266 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 768066007267 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 768066007268 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768066007269 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 768066007270 type II secretion system protein D; Region: type_II_gspD; TIGR02517 768066007271 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768066007272 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768066007273 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768066007274 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 768066007275 type II secretion system protein E; Region: type_II_gspE; TIGR02533 768066007276 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 768066007277 Walker A motif; other site 768066007278 ATP binding site [chemical binding]; other site 768066007279 Walker B motif; other site 768066007280 type II secretion system protein F; Region: GspF; TIGR02120 768066007281 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768066007282 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768066007283 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 768066007284 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 768066007285 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 768066007286 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 768066007287 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 768066007288 type II secretion system protein I; Region: gspI; TIGR01707 768066007289 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 768066007290 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 768066007291 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 768066007292 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 768066007293 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768066007294 active site 768066007295 SAM binding site [chemical binding]; other site 768066007296 homodimer interface [polypeptide binding]; other site 768066007297 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 768066007298 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768066007299 [4Fe-4S] binding site [ion binding]; other site 768066007300 molybdopterin cofactor binding site; other site 768066007301 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 768066007302 molybdopterin cofactor binding site; other site 768066007303 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768066007304 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 768066007305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066007306 active site 768066007307 phosphorylation site [posttranslational modification] 768066007308 intermolecular recognition site; other site 768066007309 ANTAR domain; Region: ANTAR; pfam03861 768066007310 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768066007311 NMT1-like family; Region: NMT1_2; pfam13379 768066007312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 768066007313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066007314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066007315 nitrite reductase subunit NirD; Provisional; Region: PRK14989 768066007316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066007317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066007318 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768066007319 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 768066007320 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 768066007321 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 768066007322 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 768066007323 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 768066007324 putative active site [active] 768066007325 PhoH-like protein; Region: PhoH; pfam02562 768066007326 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 768066007327 putative hydrolase; Provisional; Region: PRK11460 768066007328 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768066007329 DNA-binding site [nucleotide binding]; DNA binding site 768066007330 RNA-binding motif; other site 768066007331 choline dehydrogenase; Validated; Region: PRK02106 768066007332 lycopene cyclase; Region: lycopene_cycl; TIGR01789 768066007333 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768066007334 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 768066007335 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768066007336 active site 768066007337 FMN binding site [chemical binding]; other site 768066007338 substrate binding site [chemical binding]; other site 768066007339 3Fe-4S cluster binding site [ion binding]; other site 768066007340 Peptidase propeptide and YPEB domain; Region: PepSY_2; cl17877 768066007341 Predicted membrane protein [Function unknown]; Region: COG3212 768066007342 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768066007343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768066007344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066007345 active site 768066007346 phosphorylation site [posttranslational modification] 768066007347 intermolecular recognition site; other site 768066007348 dimerization interface [polypeptide binding]; other site 768066007349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066007350 DNA binding site [nucleotide binding] 768066007351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066007352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066007353 ATP binding site [chemical binding]; other site 768066007354 Mg2+ binding site [ion binding]; other site 768066007355 G-X-G motif; other site 768066007356 HPP family; Region: HPP; pfam04982 768066007357 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 768066007358 metal binding site [ion binding]; metal-binding site 768066007359 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 768066007360 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 768066007361 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 768066007362 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 768066007363 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768066007364 putative active site pocket [active] 768066007365 dimerization interface [polypeptide binding]; other site 768066007366 putative catalytic residue [active] 768066007367 threonine dehydratase; Provisional; Region: PRK07334 768066007368 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768066007369 tetramer interface [polypeptide binding]; other site 768066007370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066007371 catalytic residue [active] 768066007372 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 768066007373 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 768066007374 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 768066007375 hypothetical protein; Provisional; Region: PRK02237 768066007376 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 768066007377 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768066007378 DNA binding residues [nucleotide binding] 768066007379 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768066007380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066007381 putative substrate translocation pore; other site 768066007382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066007383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066007384 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 768066007385 dimerization interface [polypeptide binding]; other site 768066007386 substrate binding pocket [chemical binding]; other site 768066007387 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768066007388 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 768066007389 metal binding site [ion binding]; metal-binding site 768066007390 putative dimer interface [polypeptide binding]; other site 768066007391 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 768066007392 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 768066007393 Na binding site [ion binding]; other site 768066007394 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 768066007395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066007396 ATP binding site [chemical binding]; other site 768066007397 Walker B motif; other site 768066007398 arginine finger; other site 768066007399 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768066007400 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 768066007401 Na binding site [ion binding]; other site 768066007402 acetylornithine deacetylase; Validated; Region: PRK06915 768066007403 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 768066007404 metal binding site [ion binding]; metal-binding site 768066007405 dimer interface [polypeptide binding]; other site 768066007406 allantoate amidohydrolase; Reviewed; Region: PRK09290 768066007407 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768066007408 active site 768066007409 metal binding site [ion binding]; metal-binding site 768066007410 dimer interface [polypeptide binding]; other site 768066007411 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 768066007412 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 768066007413 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768066007414 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 768066007415 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 768066007416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066007417 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768066007418 putative substrate translocation pore; other site 768066007419 serine/threonine transporter SstT; Provisional; Region: PRK13628 768066007420 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 768066007421 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 768066007422 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 768066007423 active site 768066007424 catalytic tetrad [active] 768066007425 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768066007426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066007427 non-specific DNA binding site [nucleotide binding]; other site 768066007428 salt bridge; other site 768066007429 sequence-specific DNA binding site [nucleotide binding]; other site 768066007430 Cupin domain; Region: Cupin_2; cl17218 768066007431 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 768066007432 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 768066007433 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 768066007434 active site 768066007435 O-Antigen ligase; Region: Wzy_C; pfam04932 768066007436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768066007437 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 768066007438 putative ADP-binding pocket [chemical binding]; other site 768066007439 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 768066007440 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 768066007441 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 768066007442 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768066007443 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 768066007444 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768066007445 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 768066007446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066007447 active site 768066007448 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768066007449 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768066007450 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768066007451 anti sigma factor interaction site; other site 768066007452 regulatory phosphorylation site [posttranslational modification]; other site 768066007453 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066007454 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066007455 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 768066007456 DctM-like transporters; Region: DctM; pfam06808 768066007457 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066007458 short chain dehydrogenase; Provisional; Region: PRK12829 768066007459 classical (c) SDRs; Region: SDR_c; cd05233 768066007460 NAD(P) binding site [chemical binding]; other site 768066007461 active site 768066007462 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 768066007463 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768066007464 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768066007465 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 768066007466 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768066007467 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 768066007468 trimer interface [polypeptide binding]; other site 768066007469 putative metal binding site [ion binding]; other site 768066007470 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768066007471 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768066007472 DNA binding site [nucleotide binding] 768066007473 domain linker motif; other site 768066007474 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 768066007475 putative dimerization interface [polypeptide binding]; other site 768066007476 putative ligand binding site [chemical binding]; other site 768066007477 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 768066007478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 768066007479 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 768066007480 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 768066007481 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 768066007482 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 768066007483 homodimer interface [polypeptide binding]; other site 768066007484 chemical substrate binding site [chemical binding]; other site 768066007485 oligomer interface [polypeptide binding]; other site 768066007486 metal binding site [ion binding]; metal-binding site 768066007487 Part of AAA domain; Region: AAA_19; pfam13245 768066007488 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 768066007489 Uncharacterized conserved protein [Function unknown]; Region: COG3410 768066007490 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768066007491 Catalytic site [active] 768066007492 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 768066007493 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 768066007494 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 768066007495 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 768066007496 Type IV secretion system proteins; Region: T4SS; pfam07996 768066007497 integrase; Provisional; Region: int; PHA02601 768066007498 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 768066007499 catalytic residues [active] 768066007500 Int/Topo IB signature motif; other site 768066007501 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768066007502 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066007503 N-terminal plug; other site 768066007504 ligand-binding site [chemical binding]; other site 768066007505 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 768066007506 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768066007507 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 768066007508 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768066007509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066007510 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768066007511 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066007512 N-terminal plug; other site 768066007513 ligand-binding site [chemical binding]; other site 768066007514 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 768066007515 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 768066007516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066007517 S-adenosylmethionine binding site [chemical binding]; other site 768066007518 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 768066007519 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768066007520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066007521 Walker A/P-loop; other site 768066007522 ATP binding site [chemical binding]; other site 768066007523 Q-loop/lid; other site 768066007524 ABC transporter signature motif; other site 768066007525 Walker B; other site 768066007526 D-loop; other site 768066007527 H-loop/switch region; other site 768066007528 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 768066007529 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 768066007530 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 768066007531 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 768066007532 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768066007533 Walker A/P-loop; other site 768066007534 ATP binding site [chemical binding]; other site 768066007535 Q-loop/lid; other site 768066007536 ABC transporter signature motif; other site 768066007537 Walker B; other site 768066007538 D-loop; other site 768066007539 H-loop/switch region; other site 768066007540 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768066007541 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768066007542 siderophore binding site; other site 768066007543 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768066007544 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768066007545 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066007546 ABC-ATPase subunit interface; other site 768066007547 dimer interface [polypeptide binding]; other site 768066007548 putative PBP binding regions; other site 768066007549 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768066007550 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 768066007551 molybdopterin cofactor binding site; other site 768066007552 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 768066007553 molybdopterin cofactor binding site; other site 768066007554 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768066007555 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066007556 N-terminal plug; other site 768066007557 ligand-binding site [chemical binding]; other site 768066007558 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 768066007559 High-affinity nickel-transport protein; Region: NicO; cl00964 768066007560 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 768066007561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066007562 putative substrate translocation pore; other site 768066007563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066007564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066007565 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 768066007566 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 768066007567 NADH(P)-binding; Region: NAD_binding_10; pfam13460 768066007568 NAD binding site [chemical binding]; other site 768066007569 substrate binding site [chemical binding]; other site 768066007570 putative active site [active] 768066007571 Predicted transcriptional regulators [Transcription]; Region: COG1733 768066007572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768066007573 dimerization interface [polypeptide binding]; other site 768066007574 putative DNA binding site [nucleotide binding]; other site 768066007575 putative Zn2+ binding site [ion binding]; other site 768066007576 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 768066007577 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 768066007578 Walker A/P-loop; other site 768066007579 ATP binding site [chemical binding]; other site 768066007580 Q-loop/lid; other site 768066007581 ABC transporter signature motif; other site 768066007582 Walker B; other site 768066007583 D-loop; other site 768066007584 H-loop/switch region; other site 768066007585 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 768066007586 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066007587 N-terminal plug; other site 768066007588 ligand-binding site [chemical binding]; other site 768066007589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066007590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768066007591 putative substrate translocation pore; other site 768066007592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066007593 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 768066007594 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768066007595 siderophore binding site; other site 768066007596 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768066007597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066007598 ABC-ATPase subunit interface; other site 768066007599 dimer interface [polypeptide binding]; other site 768066007600 putative PBP binding regions; other site 768066007601 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768066007602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066007603 dimer interface [polypeptide binding]; other site 768066007604 putative PBP binding regions; other site 768066007605 ABC-ATPase subunit interface; other site 768066007606 hypothetical protein; Validated; Region: PRK06201 768066007607 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 768066007608 IucA / IucC family; Region: IucA_IucC; pfam04183 768066007609 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768066007610 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 768066007611 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768066007612 IucA / IucC family; Region: IucA_IucC; pfam04183 768066007613 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768066007614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 768066007615 dimer interface [polypeptide binding]; other site 768066007616 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 768066007617 active site 768066007618 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768066007619 catalytic residues [active] 768066007620 substrate binding site [chemical binding]; other site 768066007621 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 768066007622 IucA / IucC family; Region: IucA_IucC; pfam04183 768066007623 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 768066007624 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768066007625 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768066007626 Walker A/P-loop; other site 768066007627 ATP binding site [chemical binding]; other site 768066007628 Q-loop/lid; other site 768066007629 ABC transporter signature motif; other site 768066007630 Walker B; other site 768066007631 D-loop; other site 768066007632 H-loop/switch region; other site 768066007633 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 768066007634 putative dimer interface [polypeptide binding]; other site 768066007635 putative [2Fe-2S] cluster binding site [ion binding]; other site 768066007636 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768066007637 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066007638 ABC-ATPase subunit interface; other site 768066007639 dimer interface [polypeptide binding]; other site 768066007640 putative PBP binding regions; other site 768066007641 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768066007642 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768066007643 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066007644 ABC-ATPase subunit interface; other site 768066007645 dimer interface [polypeptide binding]; other site 768066007646 putative PBP binding regions; other site 768066007647 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768066007648 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 768066007649 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768066007650 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768066007651 intersubunit interface [polypeptide binding]; other site 768066007652 PRC-barrel domain; Region: PRC; pfam05239 768066007653 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768066007654 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768066007655 Walker A/P-loop; other site 768066007656 ATP binding site [chemical binding]; other site 768066007657 Q-loop/lid; other site 768066007658 ABC transporter signature motif; other site 768066007659 Walker B; other site 768066007660 D-loop; other site 768066007661 H-loop/switch region; other site 768066007662 FecCD transport family; Region: FecCD; pfam01032 768066007663 FecCD transport family; Region: FecCD; pfam01032 768066007664 ABC-ATPase subunit interface; other site 768066007665 dimer interface [polypeptide binding]; other site 768066007666 putative PBP binding regions; other site 768066007667 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 768066007668 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768066007669 siderophore binding site; other site 768066007670 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768066007671 intersubunit interface [polypeptide binding]; other site 768066007672 putative outer membrane receptor; Provisional; Region: PRK13513 768066007673 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066007674 N-terminal plug; other site 768066007675 ligand-binding site [chemical binding]; other site 768066007676 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066007677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066007678 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768066007679 putative effector binding pocket; other site 768066007680 dimerization interface [polypeptide binding]; other site 768066007681 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 768066007682 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 768066007683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768066007684 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066007685 Fusaric acid resistance protein family; Region: FUSC; pfam04632 768066007686 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768066007687 Predicted permeases [General function prediction only]; Region: COG0679 768066007688 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 768066007689 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 768066007690 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 768066007691 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 768066007692 Walker A/P-loop; other site 768066007693 ATP binding site [chemical binding]; other site 768066007694 Q-loop/lid; other site 768066007695 ABC transporter signature motif; other site 768066007696 Walker B; other site 768066007697 D-loop; other site 768066007698 H-loop/switch region; other site 768066007699 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768066007700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066007701 dimer interface [polypeptide binding]; other site 768066007702 conserved gate region; other site 768066007703 putative PBP binding loops; other site 768066007704 ABC-ATPase subunit interface; other site 768066007705 BCCT family transporter; Region: BCCT; pfam02028 768066007706 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 768066007707 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 768066007708 GDP-binding site [chemical binding]; other site 768066007709 ACT binding site; other site 768066007710 IMP binding site; other site 768066007711 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 768066007712 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768066007713 dimer interface [polypeptide binding]; other site 768066007714 motif 1; other site 768066007715 active site 768066007716 motif 2; other site 768066007717 motif 3; other site 768066007718 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 768066007719 FtsH protease regulator HflC; Provisional; Region: PRK11029 768066007720 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 768066007721 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 768066007722 HflK protein; Region: hflK; TIGR01933 768066007723 GTPase HflX; Provisional; Region: PRK11058 768066007724 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 768066007725 HflX GTPase family; Region: HflX; cd01878 768066007726 G1 box; other site 768066007727 GTP/Mg2+ binding site [chemical binding]; other site 768066007728 Switch I region; other site 768066007729 G2 box; other site 768066007730 G3 box; other site 768066007731 Switch II region; other site 768066007732 G4 box; other site 768066007733 G5 box; other site 768066007734 bacterial Hfq-like; Region: Hfq; cd01716 768066007735 hexamer interface [polypeptide binding]; other site 768066007736 Sm1 motif; other site 768066007737 RNA binding site [nucleotide binding]; other site 768066007738 Sm2 motif; other site 768066007739 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 768066007740 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 768066007741 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 768066007742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066007743 ATP binding site [chemical binding]; other site 768066007744 Mg2+ binding site [ion binding]; other site 768066007745 G-X-G motif; other site 768066007746 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 768066007747 ATP binding site [chemical binding]; other site 768066007748 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 768066007749 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 768066007750 AMIN domain; Region: AMIN; pfam11741 768066007751 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768066007752 active site 768066007753 metal binding site [ion binding]; metal-binding site 768066007754 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 768066007755 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768066007756 Uncharacterized conserved protein [Function unknown]; Region: COG0062 768066007757 putative carbohydrate kinase; Provisional; Region: PRK10565 768066007758 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 768066007759 putative substrate binding site [chemical binding]; other site 768066007760 putative ATP binding site [chemical binding]; other site 768066007761 epoxyqueuosine reductase; Region: TIGR00276 768066007762 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 768066007763 seryl-tRNA synthetase; Provisional; Region: PRK05431 768066007764 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 768066007765 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 768066007766 dimer interface [polypeptide binding]; other site 768066007767 active site 768066007768 motif 1; other site 768066007769 motif 2; other site 768066007770 motif 3; other site 768066007771 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768066007772 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 768066007773 TrkA-N domain; Region: TrkA_N; pfam02254 768066007774 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 768066007775 active site 768066007776 ribulose/triose binding site [chemical binding]; other site 768066007777 phosphate binding site [ion binding]; other site 768066007778 substrate (anthranilate) binding pocket [chemical binding]; other site 768066007779 product (indole) binding pocket [chemical binding]; other site 768066007780 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 768066007781 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768066007782 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768066007783 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 768066007784 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768066007785 glutamine binding [chemical binding]; other site 768066007786 catalytic triad [active] 768066007787 anthranilate synthase component I; Provisional; Region: PRK13565 768066007788 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768066007789 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 768066007790 phosphoglycolate phosphatase; Provisional; Region: PRK13222 768066007791 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 768066007792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066007793 motif II; other site 768066007794 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768066007795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066007796 Conserved TM helix; Region: TM_helix; pfam05552 768066007797 mechanosensitive channel MscS; Provisional; Region: PRK10334 768066007798 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768066007799 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 768066007800 GIY-YIG motif/motif A; other site 768066007801 putative active site [active] 768066007802 putative metal binding site [ion binding]; other site 768066007803 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 768066007804 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 768066007805 substrate binding site [chemical binding]; other site 768066007806 hexamer interface [polypeptide binding]; other site 768066007807 metal binding site [ion binding]; metal-binding site 768066007808 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 768066007809 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 768066007810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768066007811 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768066007812 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768066007813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066007814 dimer interface [polypeptide binding]; other site 768066007815 conserved gate region; other site 768066007816 putative PBP binding loops; other site 768066007817 ABC-ATPase subunit interface; other site 768066007818 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768066007819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066007820 dimer interface [polypeptide binding]; other site 768066007821 conserved gate region; other site 768066007822 putative PBP binding loops; other site 768066007823 ABC-ATPase subunit interface; other site 768066007824 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 768066007825 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 768066007826 Walker A/P-loop; other site 768066007827 ATP binding site [chemical binding]; other site 768066007828 Q-loop/lid; other site 768066007829 ABC transporter signature motif; other site 768066007830 Walker B; other site 768066007831 D-loop; other site 768066007832 H-loop/switch region; other site 768066007833 TOBE-like domain; Region: TOBE_3; pfam12857 768066007834 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 768066007835 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 768066007836 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 768066007837 Bacterial SH3 domain homologues; Region: SH3b; smart00287 768066007838 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 768066007839 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768066007840 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768066007841 FeS/SAM binding site; other site 768066007842 TRAM domain; Region: TRAM; pfam01938 768066007843 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768066007844 PhoH-like protein; Region: PhoH; pfam02562 768066007845 metal-binding heat shock protein; Provisional; Region: PRK00016 768066007846 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 768066007847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768066007848 Transporter associated domain; Region: CorC_HlyC; smart01091 768066007849 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 768066007850 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 768066007851 putative active site [active] 768066007852 catalytic triad [active] 768066007853 putative dimer interface [polypeptide binding]; other site 768066007854 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 768066007855 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 768066007856 Phasin protein; Region: Phasin_2; cl11491 768066007857 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 768066007858 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 768066007859 Tetramer interface [polypeptide binding]; other site 768066007860 active site 768066007861 FMN-binding site [chemical binding]; other site 768066007862 HemK family putative methylases; Region: hemK_fam; TIGR00536 768066007863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066007864 S-adenosylmethionine binding site [chemical binding]; other site 768066007865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 768066007866 Smr domain; Region: Smr; pfam01713 768066007867 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 768066007868 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 768066007869 active site 768066007870 nucleophile elbow; other site 768066007871 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 768066007872 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 768066007873 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768066007874 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768066007875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066007876 DNA-binding site [nucleotide binding]; DNA binding site 768066007877 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768066007878 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 768066007879 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 768066007880 extended (e) SDRs; Region: SDR_e; cd08946 768066007881 NAD(P) binding site [chemical binding]; other site 768066007882 active site 768066007883 substrate binding site [chemical binding]; other site 768066007884 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 768066007885 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 768066007886 active site 768066007887 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 768066007888 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 768066007889 active site pocket [active] 768066007890 DctM-like transporters; Region: DctM; pfam06808 768066007891 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066007892 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 768066007893 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066007894 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066007895 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 768066007896 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 768066007897 dimer interface [polypeptide binding]; other site 768066007898 NADP binding site [chemical binding]; other site 768066007899 catalytic residues [active] 768066007900 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 768066007901 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 768066007902 active site 768066007903 tetramer interface [polypeptide binding]; other site 768066007904 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 768066007905 galactarate dehydratase; Region: galactar-dH20; TIGR03248 768066007906 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 768066007907 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 768066007908 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 768066007909 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 768066007910 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768066007911 putative active site [active] 768066007912 catalytic residue [active] 768066007913 Predicted permeases [General function prediction only]; Region: COG0679 768066007914 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 768066007915 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 768066007916 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768066007917 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 768066007918 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 768066007919 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 768066007920 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 768066007921 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 768066007922 ligand binding site [chemical binding]; other site 768066007923 homodimer interface [polypeptide binding]; other site 768066007924 NAD(P) binding site [chemical binding]; other site 768066007925 trimer interface B [polypeptide binding]; other site 768066007926 trimer interface A [polypeptide binding]; other site 768066007927 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 768066007928 heat shock protein 90; Provisional; Region: PRK05218 768066007929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066007930 ATP binding site [chemical binding]; other site 768066007931 Mg2+ binding site [ion binding]; other site 768066007932 G-X-G motif; other site 768066007933 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 768066007934 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768066007935 CoenzymeA binding site [chemical binding]; other site 768066007936 subunit interaction site [polypeptide binding]; other site 768066007937 PHB binding site; other site 768066007938 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768066007939 CoenzymeA binding site [chemical binding]; other site 768066007940 subunit interaction site [polypeptide binding]; other site 768066007941 PHB binding site; other site 768066007942 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 768066007943 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768066007944 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768066007945 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768066007946 catalytic residue [active] 768066007947 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768066007948 TM2 domain; Region: TM2; cl00984 768066007949 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768066007950 DNA-binding site [nucleotide binding]; DNA binding site 768066007951 RNA-binding motif; other site 768066007952 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 768066007953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066007954 putative metal binding site [ion binding]; other site 768066007955 lipid kinase; Reviewed; Region: PRK13054 768066007956 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 768066007957 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 768066007958 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768066007959 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 768066007960 TrkA-N domain; Region: TrkA_N; pfam02254 768066007961 aminopeptidase N; Provisional; Region: pepN; PRK14015 768066007962 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 768066007963 active site 768066007964 Zn binding site [ion binding]; other site 768066007965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 768066007966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066007967 Coenzyme A binding pocket [chemical binding]; other site 768066007968 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 768066007969 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 768066007970 homodimer interface [polypeptide binding]; other site 768066007971 Walker A motif; other site 768066007972 ATP binding site [chemical binding]; other site 768066007973 hydroxycobalamin binding site [chemical binding]; other site 768066007974 Walker B motif; other site 768066007975 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 768066007976 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768066007977 active site 768066007978 catalytic site [active] 768066007979 substrate binding site [chemical binding]; other site 768066007980 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 768066007981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768066007982 ligand binding site [chemical binding]; other site 768066007983 flexible hinge region; other site 768066007984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 768066007985 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768066007986 metal binding triad; other site 768066007987 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 768066007988 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 768066007989 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 768066007990 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 768066007991 putative active site [active] 768066007992 putative substrate binding site [chemical binding]; other site 768066007993 putative cosubstrate binding site; other site 768066007994 catalytic site [active] 768066007995 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 768066007996 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 768066007997 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 768066007998 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 768066007999 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 768066008000 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 768066008001 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 768066008002 hydroxyglutarate oxidase; Provisional; Region: PRK11728 768066008003 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 768066008004 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 768066008005 dimer interface [polypeptide binding]; other site 768066008006 active site 768066008007 glycine-pyridoxal phosphate binding site [chemical binding]; other site 768066008008 folate binding site [chemical binding]; other site 768066008009 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066008010 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 768066008011 conserved cys residue [active] 768066008012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066008013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066008014 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 768066008015 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 768066008016 FAD binding pocket [chemical binding]; other site 768066008017 FAD binding motif [chemical binding]; other site 768066008018 phosphate binding motif [ion binding]; other site 768066008019 beta-alpha-beta structure motif; other site 768066008020 NAD binding pocket [chemical binding]; other site 768066008021 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768066008022 catalytic loop [active] 768066008023 iron binding site [ion binding]; other site 768066008024 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 768066008025 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 768066008026 [2Fe-2S] cluster binding site [ion binding]; other site 768066008027 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 768066008028 putative alpha subunit interface [polypeptide binding]; other site 768066008029 putative active site [active] 768066008030 putative substrate binding site [chemical binding]; other site 768066008031 Fe binding site [ion binding]; other site 768066008032 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 768066008033 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 768066008034 NAD binding site [chemical binding]; other site 768066008035 catalytic Zn binding site [ion binding]; other site 768066008036 structural Zn binding site [ion binding]; other site 768066008037 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768066008038 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 768066008039 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768066008040 Electron transfer flavoprotein domain; Region: ETF; pfam01012 768066008041 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 768066008042 Electron transfer flavoprotein domain; Region: ETF; smart00893 768066008043 Ligand Binding Site [chemical binding]; other site 768066008044 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 768066008045 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 768066008046 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768066008047 Cysteine-rich domain; Region: CCG; pfam02754 768066008048 Cysteine-rich domain; Region: CCG; pfam02754 768066008049 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 768066008050 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 768066008051 putative active site [active] 768066008052 putative FMN binding site [chemical binding]; other site 768066008053 putative substrate binding site [chemical binding]; other site 768066008054 putative catalytic residue [active] 768066008055 V4R domain; Region: V4R; cl15268 768066008056 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 768066008057 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 768066008058 active site 768066008059 dimer interface [polypeptide binding]; other site 768066008060 Transglycosylase; Region: Transgly; cl17702 768066008061 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 768066008062 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 768066008063 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 768066008064 conserved cys residue [active] 768066008065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066008066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066008067 S-formylglutathione hydrolase; Region: PLN02442 768066008068 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 768066008069 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 768066008070 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 768066008071 substrate binding site [chemical binding]; other site 768066008072 catalytic Zn binding site [ion binding]; other site 768066008073 NAD binding site [chemical binding]; other site 768066008074 structural Zn binding site [ion binding]; other site 768066008075 dimer interface [polypeptide binding]; other site 768066008076 LysR family transcriptional regulator; Provisional; Region: PRK14997 768066008077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066008078 dimerization interface [polypeptide binding]; other site 768066008079 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 768066008080 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 768066008081 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 768066008082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066008083 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066008084 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768066008085 dimerization interface [polypeptide binding]; other site 768066008086 substrate binding pocket [chemical binding]; other site 768066008087 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 768066008088 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 768066008089 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768066008090 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 768066008091 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768066008092 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768066008093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768066008094 DNA binding residues [nucleotide binding] 768066008095 DNA primase; Validated; Region: dnaG; PRK05667 768066008096 CHC2 zinc finger; Region: zf-CHC2; pfam01807 768066008097 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 768066008098 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 768066008099 active site 768066008100 metal binding site [ion binding]; metal-binding site 768066008101 interdomain interaction site; other site 768066008102 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 768066008103 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 768066008104 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 768066008105 UGMP family protein; Validated; Region: PRK09604 768066008106 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768066008107 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 768066008108 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 768066008109 active site 768066008110 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 768066008111 catalytic center binding site [active] 768066008112 ATP binding site [chemical binding]; other site 768066008113 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768066008114 active site 768066008115 NTP binding site [chemical binding]; other site 768066008116 metal binding triad [ion binding]; metal-binding site 768066008117 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768066008118 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 768066008119 active site residue [active] 768066008120 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 768066008121 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 768066008122 active site 768066008123 metal binding site [ion binding]; metal-binding site 768066008124 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 768066008125 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 768066008126 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 768066008127 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 768066008128 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 768066008129 SurA N-terminal domain; Region: SurA_N; pfam09312 768066008130 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 768066008131 OstA-like protein; Region: OstA; cl00844 768066008132 Organic solvent tolerance protein; Region: OstA_C; pfam04453 768066008133 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 768066008134 Phosphotransferase enzyme family; Region: APH; pfam01636 768066008135 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 768066008136 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 768066008137 Substrate binding site; other site 768066008138 metal-binding site 768066008139 OsmC-like protein; Region: OsmC; cl00767 768066008140 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 768066008141 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 768066008142 diiron binding motif [ion binding]; other site 768066008143 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 768066008144 nucleotide binding site/active site [active] 768066008145 HIT family signature motif; other site 768066008146 catalytic residue [active] 768066008147 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 768066008148 classical (c) SDRs; Region: SDR_c; cd05233 768066008149 NAD(P) binding site [chemical binding]; other site 768066008150 active site 768066008151 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 768066008152 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 768066008153 putative ligand binding site [chemical binding]; other site 768066008154 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768066008155 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768066008156 Walker A/P-loop; other site 768066008157 ATP binding site [chemical binding]; other site 768066008158 Q-loop/lid; other site 768066008159 ABC transporter signature motif; other site 768066008160 Walker B; other site 768066008161 D-loop; other site 768066008162 H-loop/switch region; other site 768066008163 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768066008164 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768066008165 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768066008166 TM-ABC transporter signature motif; other site 768066008167 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 768066008168 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 768066008169 N- and C-terminal domain interface [polypeptide binding]; other site 768066008170 putative active site [active] 768066008171 MgATP binding site [chemical binding]; other site 768066008172 catalytic site [active] 768066008173 metal binding site [ion binding]; metal-binding site 768066008174 putative xylulose binding site [chemical binding]; other site 768066008175 putative homodimer interface [polypeptide binding]; other site 768066008176 short chain dehydrogenase; Provisional; Region: PRK07060 768066008177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066008178 NAD(P) binding site [chemical binding]; other site 768066008179 active site 768066008180 transaldolase-like protein; Provisional; Region: PTZ00411 768066008181 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768066008182 active site 768066008183 dimer interface [polypeptide binding]; other site 768066008184 catalytic residue [active] 768066008185 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768066008186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768066008187 DNA binding site [nucleotide binding] 768066008188 domain linker motif; other site 768066008189 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 768066008190 dimerization interface [polypeptide binding]; other site 768066008191 ligand binding site [chemical binding]; other site 768066008192 phosphoribulokinase; Provisional; Region: PRK15453 768066008193 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768066008194 active site 768066008195 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 768066008196 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 768066008197 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 768066008198 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 768066008199 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 768066008200 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 768066008201 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 768066008202 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 768066008203 RNA methyltransferase, RsmE family; Region: TIGR00046 768066008204 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 768066008205 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768066008206 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768066008207 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768066008208 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 768066008209 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 768066008210 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 768066008211 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 768066008212 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 768066008213 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768066008214 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659 768066008215 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 768066008216 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 768066008217 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 768066008218 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768066008219 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 768066008220 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 768066008221 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768066008222 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 768066008223 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 768066008224 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 768066008225 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 768066008226 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 768066008227 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 768066008228 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 768066008229 ferrochelatase; Reviewed; Region: hemH; PRK00035 768066008230 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 768066008231 C-terminal domain interface [polypeptide binding]; other site 768066008232 active site 768066008233 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 768066008234 active site 768066008235 N-terminal domain interface [polypeptide binding]; other site 768066008236 replicative DNA helicase; Provisional; Region: PRK05748 768066008237 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768066008238 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768066008239 Walker A motif; other site 768066008240 ATP binding site [chemical binding]; other site 768066008241 Walker B motif; other site 768066008242 DNA binding loops [nucleotide binding] 768066008243 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 768066008244 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 768066008245 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 768066008246 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 768066008247 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 768066008248 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 768066008249 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 768066008250 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768066008251 ribonuclease R; Region: RNase_R; TIGR02063 768066008252 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 768066008253 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768066008254 RNB domain; Region: RNB; pfam00773 768066008255 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 768066008256 RNA binding site [nucleotide binding]; other site 768066008257 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 768066008258 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 768066008259 active site 768066008260 substrate binding site [chemical binding]; other site 768066008261 Mg2+ binding site [ion binding]; other site 768066008262 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768066008263 AsnC family; Region: AsnC_trans_reg; pfam01037 768066008264 SpoVR family protein; Provisional; Region: PRK11767 768066008265 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 768066008266 hypothetical protein; Provisional; Region: PRK05325 768066008267 PrkA family serine protein kinase; Provisional; Region: PRK15455 768066008268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066008269 Walker A motif; other site 768066008270 ATP binding site [chemical binding]; other site 768066008271 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 768066008272 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 768066008273 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 768066008274 active site 768066008275 FMN binding site [chemical binding]; other site 768066008276 2,4-decadienoyl-CoA binding site; other site 768066008277 catalytic residue [active] 768066008278 4Fe-4S cluster binding site [ion binding]; other site 768066008279 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768066008280 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 768066008281 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 768066008282 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 768066008283 Low-spin heme binding site [chemical binding]; other site 768066008284 Putative water exit pathway; other site 768066008285 Binuclear center (active site) [active] 768066008286 Putative proton exit pathway; other site 768066008287 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 768066008288 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 768066008289 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 768066008290 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 768066008291 Cytochrome c; Region: Cytochrom_C; pfam00034 768066008292 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768066008293 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 768066008294 4Fe-4S binding domain; Region: Fer4_5; pfam12801 768066008295 4Fe-4S binding domain; Region: Fer4; pfam00037 768066008296 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 768066008297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 768066008298 FixH; Region: FixH; pfam05751 768066008299 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 768066008300 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768066008301 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768066008302 metal-binding site [ion binding] 768066008303 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768066008304 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768066008305 Family description; Region: DsbD_2; pfam13386 768066008306 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 768066008307 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 768066008308 Ligand Binding Site [chemical binding]; other site 768066008309 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 768066008310 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768066008311 active site 768066008312 substrate binding site [chemical binding]; other site 768066008313 catalytic site [active] 768066008314 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 768066008315 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768066008316 ligand binding site [chemical binding]; other site 768066008317 flexible hinge region; other site 768066008318 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 768066008319 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768066008320 metal binding triad; other site 768066008321 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 768066008322 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768066008323 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 768066008324 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768066008325 Na binding site [ion binding]; other site 768066008326 YebO-like protein; Region: YebO; pfam13974 768066008327 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768066008328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066008329 DNA-binding site [nucleotide binding]; DNA binding site 768066008330 FCD domain; Region: FCD; pfam07729 768066008331 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 768066008332 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 768066008333 NAD binding site [chemical binding]; other site 768066008334 homotetramer interface [polypeptide binding]; other site 768066008335 homodimer interface [polypeptide binding]; other site 768066008336 active site 768066008337 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768066008338 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768066008339 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 768066008340 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 768066008341 putative NAD(P) binding site [chemical binding]; other site 768066008342 catalytic Zn binding site [ion binding]; other site 768066008343 structural Zn binding site [ion binding]; other site 768066008344 galactarate dehydratase; Region: galactar-dH20; TIGR03248 768066008345 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 768066008346 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 768066008347 altronate oxidoreductase; Provisional; Region: PRK03643 768066008348 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 768066008349 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066008350 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066008351 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 768066008352 DctM-like transporters; Region: DctM; pfam06808 768066008353 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066008354 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 768066008355 Na binding site [ion binding]; other site 768066008356 PAS fold; Region: PAS_7; pfam12860 768066008357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768066008358 putative active site [active] 768066008359 heme pocket [chemical binding]; other site 768066008360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066008361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066008362 dimer interface [polypeptide binding]; other site 768066008363 phosphorylation site [posttranslational modification] 768066008364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066008365 ATP binding site [chemical binding]; other site 768066008366 Mg2+ binding site [ion binding]; other site 768066008367 G-X-G motif; other site 768066008368 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768066008369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066008370 active site 768066008371 phosphorylation site [posttranslational modification] 768066008372 intermolecular recognition site; other site 768066008373 manganese transport protein MntH; Reviewed; Region: PRK00701 768066008374 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768066008375 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 768066008376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066008377 DNA-binding site [nucleotide binding]; DNA binding site 768066008378 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 768066008379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768066008380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066008381 active site 768066008382 phosphorylation site [posttranslational modification] 768066008383 intermolecular recognition site; other site 768066008384 dimerization interface [polypeptide binding]; other site 768066008385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768066008386 DNA binding residues [nucleotide binding] 768066008387 dimerization interface [polypeptide binding]; other site 768066008388 acetyl-CoA synthetase; Provisional; Region: PRK00174 768066008389 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 768066008390 active site 768066008391 CoA binding site [chemical binding]; other site 768066008392 acyl-activating enzyme (AAE) consensus motif; other site 768066008393 AMP binding site [chemical binding]; other site 768066008394 acetate binding site [chemical binding]; other site 768066008395 hypothetical protein; Provisional; Region: PRK04860 768066008396 SprT homologues; Region: SprT; cl01182 768066008397 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 768066008398 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 768066008399 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768066008400 putative active site [active] 768066008401 catalytic site [active] 768066008402 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 768066008403 putative active site [active] 768066008404 catalytic site [active] 768066008405 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 768066008406 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 768066008407 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768066008408 Glycoprotease family; Region: Peptidase_M22; pfam00814 768066008409 adenylate kinase; Reviewed; Region: adk; PRK00279 768066008410 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 768066008411 AMP-binding site [chemical binding]; other site 768066008412 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 768066008413 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768066008414 E3 interaction surface; other site 768066008415 lipoyl attachment site [posttranslational modification]; other site 768066008416 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 768066008417 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768066008418 E3 interaction surface; other site 768066008419 lipoyl attachment site [posttranslational modification]; other site 768066008420 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 768066008421 E3 interaction surface; other site 768066008422 lipoyl attachment site [posttranslational modification]; other site 768066008423 e3 binding domain; Region: E3_binding; pfam02817 768066008424 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 768066008425 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 768066008426 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 768066008427 dimer interface [polypeptide binding]; other site 768066008428 TPP-binding site [chemical binding]; other site 768066008429 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 768066008430 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 768066008431 amidase catalytic site [active] 768066008432 Zn binding residues [ion binding]; other site 768066008433 substrate binding site [chemical binding]; other site 768066008434 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 768066008435 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 768066008436 dimerization interface [polypeptide binding]; other site 768066008437 active site 768066008438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066008439 Coenzyme A binding pocket [chemical binding]; other site 768066008440 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 768066008441 homodimer interaction site [polypeptide binding]; other site 768066008442 cofactor binding site; other site 768066008443 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 768066008444 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 768066008445 ATP binding site [chemical binding]; other site 768066008446 active site 768066008447 substrate binding site [chemical binding]; other site 768066008448 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 768066008449 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 768066008450 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768066008451 dihydrodipicolinate synthase; Region: dapA; TIGR00674 768066008452 dimer interface [polypeptide binding]; other site 768066008453 active site 768066008454 catalytic residue [active] 768066008455 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 768066008456 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 768066008457 catalytic triad [active] 768066008458 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768066008459 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768066008460 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 768066008461 Peptidase family M48; Region: Peptidase_M48; cl12018 768066008462 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 768066008463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066008464 Walker A motif; other site 768066008465 ATP binding site [chemical binding]; other site 768066008466 Walker B motif; other site 768066008467 arginine finger; other site 768066008468 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768066008469 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 768066008470 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 768066008471 tetramer interfaces [polypeptide binding]; other site 768066008472 binuclear metal-binding site [ion binding]; other site 768066008473 thiamine monophosphate kinase; Provisional; Region: PRK05731 768066008474 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 768066008475 ATP binding site [chemical binding]; other site 768066008476 dimerization interface [polypeptide binding]; other site 768066008477 transcription antitermination factor NusB; Region: nusB; TIGR01951 768066008478 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 768066008479 homopentamer interface [polypeptide binding]; other site 768066008480 active site 768066008481 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 768066008482 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 768066008483 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 768066008484 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 768066008485 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 768066008486 catalytic motif [active] 768066008487 Zn binding site [ion binding]; other site 768066008488 RibD C-terminal domain; Region: RibD_C; cl17279 768066008489 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 768066008490 ATP cone domain; Region: ATP-cone; pfam03477 768066008491 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 768066008492 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768066008493 NAD binding site [chemical binding]; other site 768066008494 homodimer interface [polypeptide binding]; other site 768066008495 active site 768066008496 substrate binding site [chemical binding]; other site 768066008497 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 768066008498 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768066008499 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 768066008500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768066008501 active site 768066008502 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 768066008503 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768066008504 UDP-galactopyranose mutase; Region: GLF; pfam03275 768066008505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768066008506 binding surface 768066008507 TPR motif; other site 768066008508 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 768066008509 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768066008510 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 768066008511 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 768066008512 dimer interface [polypeptide binding]; other site 768066008513 active site 768066008514 glycine-pyridoxal phosphate binding site [chemical binding]; other site 768066008515 folate binding site [chemical binding]; other site 768066008516 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 768066008517 homotrimer interaction site [polypeptide binding]; other site 768066008518 putative active site [active] 768066008519 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 768066008520 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768066008521 Walker A/P-loop; other site 768066008522 ATP binding site [chemical binding]; other site 768066008523 Q-loop/lid; other site 768066008524 ABC transporter signature motif; other site 768066008525 Walker B; other site 768066008526 D-loop; other site 768066008527 H-loop/switch region; other site 768066008528 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 768066008529 active site 768066008530 catalytic triad [active] 768066008531 oxyanion hole [active] 768066008532 switch loop; other site 768066008533 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768066008534 EamA-like transporter family; Region: EamA; pfam00892 768066008535 EamA-like transporter family; Region: EamA; pfam00892 768066008536 Rdx family; Region: Rdx; cl01407 768066008537 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 768066008538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066008539 Walker A/P-loop; other site 768066008540 ATP binding site [chemical binding]; other site 768066008541 Q-loop/lid; other site 768066008542 ABC transporter signature motif; other site 768066008543 Walker B; other site 768066008544 D-loop; other site 768066008545 H-loop/switch region; other site 768066008546 ABC transporter; Region: ABC_tran_2; pfam12848 768066008547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066008548 Q-loop/lid; other site 768066008549 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768066008550 ABC transporter signature motif; other site 768066008551 Walker B; other site 768066008552 D-loop; other site 768066008553 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 768066008554 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768066008555 putative acyl-acceptor binding pocket; other site 768066008556 alanine racemase; Reviewed; Region: alr; PRK00053 768066008557 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 768066008558 active site 768066008559 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768066008560 substrate binding site [chemical binding]; other site 768066008561 catalytic residues [active] 768066008562 dimer interface [polypeptide binding]; other site 768066008563 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 768066008564 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768066008565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768066008566 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768066008567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768066008568 DNA binding residues [nucleotide binding] 768066008569 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768066008570 Peptidase family M23; Region: Peptidase_M23; pfam01551 768066008571 Domain of unknown function (DUF368); Region: DUF368; pfam04018 768066008572 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 768066008573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066008574 S-adenosylmethionine binding site [chemical binding]; other site 768066008575 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 768066008576 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 768066008577 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 768066008578 Permutation of conserved domain; other site 768066008579 active site 768066008580 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 768066008581 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 768066008582 homotrimer interaction site [polypeptide binding]; other site 768066008583 zinc binding site [ion binding]; other site 768066008584 CDP-binding sites; other site 768066008585 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 768066008586 substrate binding site; other site 768066008587 dimer interface; other site 768066008588 Septum formation initiator; Region: DivIC; cl17659 768066008589 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 768066008590 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 768066008591 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 768066008592 putative active site [active] 768066008593 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768066008594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066008595 Walker A motif; other site 768066008596 ATP binding site [chemical binding]; other site 768066008597 Walker B motif; other site 768066008598 arginine finger; other site 768066008599 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 768066008600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 768066008601 Protein of unknown function, DUF482; Region: DUF482; pfam04339 768066008602 phosphogluconate dehydratase; Validated; Region: PRK09054 768066008603 6-phosphogluconate dehydratase; Region: edd; TIGR01196 768066008604 glucokinase, proteobacterial type; Region: glk; TIGR00749 768066008605 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768066008606 nucleotide binding site [chemical binding]; other site 768066008607 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 768066008608 active site 768066008609 phosphate binding residues; other site 768066008610 catalytic residues [active] 768066008611 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768066008612 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 768066008613 putative substrate binding site [chemical binding]; other site 768066008614 putative ATP binding site [chemical binding]; other site 768066008615 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 768066008616 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 768066008617 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 768066008618 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 768066008619 active site 768066008620 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 768066008621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066008622 DNA-binding site [nucleotide binding]; DNA binding site 768066008623 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 768066008624 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 768066008625 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 768066008626 active site 768066008627 intersubunit interface [polypeptide binding]; other site 768066008628 catalytic residue [active] 768066008629 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 768066008630 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 768066008631 putative active site [active] 768066008632 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 768066008633 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 768066008634 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 768066008635 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 768066008636 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768066008637 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768066008638 putative active site [active] 768066008639 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 768066008640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066008641 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768066008642 Walker A/P-loop; other site 768066008643 ATP binding site [chemical binding]; other site 768066008644 Q-loop/lid; other site 768066008645 ABC transporter signature motif; other site 768066008646 Walker B; other site 768066008647 D-loop; other site 768066008648 H-loop/switch region; other site 768066008649 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768066008650 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 768066008651 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 768066008652 homotrimer interaction site [polypeptide binding]; other site 768066008653 putative active site [active] 768066008654 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768066008655 Ligand Binding Site [chemical binding]; other site 768066008656 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768066008657 Ligand Binding Site [chemical binding]; other site 768066008658 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768066008659 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768066008660 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768066008661 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768066008662 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768066008663 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 768066008664 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 768066008665 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 768066008666 dimer interface [polypeptide binding]; other site 768066008667 active site residues [active] 768066008668 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 768066008669 Uncharacterized conserved protein [Function unknown]; Region: COG1359 768066008670 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 768066008671 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066008672 active site 768066008673 metal binding site [ion binding]; metal-binding site 768066008674 hypothetical protein; Provisional; Region: PRK11622 768066008675 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 768066008676 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 768066008677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066008678 dimer interface [polypeptide binding]; other site 768066008679 conserved gate region; other site 768066008680 ABC-ATPase subunit interface; other site 768066008681 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 768066008682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066008683 Walker A/P-loop; other site 768066008684 ATP binding site [chemical binding]; other site 768066008685 Q-loop/lid; other site 768066008686 ABC transporter signature motif; other site 768066008687 Walker B; other site 768066008688 D-loop; other site 768066008689 H-loop/switch region; other site 768066008690 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 768066008691 hypothetical protein; Provisional; Region: PRK05409 768066008692 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 768066008693 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 768066008694 Predicted membrane protein [Function unknown]; Region: COG2259 768066008695 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 768066008696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768066008697 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768066008698 DNA binding residues [nucleotide binding] 768066008699 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 768066008700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768066008701 motif II; other site 768066008702 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 768066008703 ectoine utilization protein EutC; Validated; Region: PRK08291 768066008704 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 768066008705 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768066008706 tetramer interface [polypeptide binding]; other site 768066008707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066008708 catalytic residue [active] 768066008709 hypothetical protein; Provisional; Region: PRK07482 768066008710 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066008711 inhibitor-cofactor binding pocket; inhibition site 768066008712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066008713 catalytic residue [active] 768066008714 succinic semialdehyde dehydrogenase; Region: PLN02278 768066008715 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 768066008716 tetramerization interface [polypeptide binding]; other site 768066008717 NAD(P) binding site [chemical binding]; other site 768066008718 catalytic residues [active] 768066008719 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768066008720 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768066008721 putative DNA binding site [nucleotide binding]; other site 768066008722 putative Zn2+ binding site [ion binding]; other site 768066008723 AsnC family; Region: AsnC_trans_reg; pfam01037 768066008724 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 768066008725 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 768066008726 putative active site [active] 768066008727 Zn binding site [ion binding]; other site 768066008728 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 768066008729 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768066008730 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 768066008731 active site 768066008732 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 768066008733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066008734 DNA-binding site [nucleotide binding]; DNA binding site 768066008735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066008736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066008737 homodimer interface [polypeptide binding]; other site 768066008738 catalytic residue [active] 768066008739 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 768066008740 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 768066008741 putative ligand binding site [chemical binding]; other site 768066008742 NAD binding site [chemical binding]; other site 768066008743 dimerization interface [polypeptide binding]; other site 768066008744 catalytic site [active] 768066008745 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 768066008746 Isochorismatase family; Region: Isochorismatase; pfam00857 768066008747 catalytic triad [active] 768066008748 metal binding site [ion binding]; metal-binding site 768066008749 conserved cis-peptide bond; other site 768066008750 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 768066008751 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 768066008752 active site 768066008753 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 768066008754 conserved cys residue [active] 768066008755 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 768066008756 Predicted membrane protein [Function unknown]; Region: COG2431 768066008757 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768066008758 trimer interface; other site 768066008759 sugar binding site [chemical binding]; other site 768066008760 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768066008761 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 768066008762 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 768066008763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066008764 dimer interface [polypeptide binding]; other site 768066008765 conserved gate region; other site 768066008766 putative PBP binding loops; other site 768066008767 ABC-ATPase subunit interface; other site 768066008768 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768066008769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066008770 dimer interface [polypeptide binding]; other site 768066008771 conserved gate region; other site 768066008772 ABC-ATPase subunit interface; other site 768066008773 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 768066008774 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 768066008775 active site 768066008776 catalytic site [active] 768066008777 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 768066008778 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 768066008779 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768066008780 Walker A/P-loop; other site 768066008781 ATP binding site [chemical binding]; other site 768066008782 Q-loop/lid; other site 768066008783 ABC transporter signature motif; other site 768066008784 Walker B; other site 768066008785 D-loop; other site 768066008786 H-loop/switch region; other site 768066008787 TOBE domain; Region: TOBE_2; pfam08402 768066008788 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 768066008789 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 768066008790 Walker A/P-loop; other site 768066008791 ATP binding site [chemical binding]; other site 768066008792 Q-loop/lid; other site 768066008793 ABC transporter signature motif; other site 768066008794 Walker B; other site 768066008795 D-loop; other site 768066008796 H-loop/switch region; other site 768066008797 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 768066008798 Maltose operon periplasmic protein precursor (MalM); Region: MalM; cl11647 768066008799 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 768066008800 trimer interface; other site 768066008801 sugar binding site [chemical binding]; other site 768066008802 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 768066008803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066008804 dimer interface [polypeptide binding]; other site 768066008805 conserved gate region; other site 768066008806 putative PBP binding loops; other site 768066008807 ABC-ATPase subunit interface; other site 768066008808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066008809 dimer interface [polypeptide binding]; other site 768066008810 conserved gate region; other site 768066008811 putative PBP binding loops; other site 768066008812 ABC-ATPase subunit interface; other site 768066008813 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 768066008814 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 768066008815 transcriptional regulator MalT; Provisional; Region: PRK04841 768066008816 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768066008817 DNA binding residues [nucleotide binding] 768066008818 dimerization interface [polypeptide binding]; other site 768066008819 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 768066008820 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 768066008821 active site 768066008822 catalytic site [active] 768066008823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 768066008824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768066008825 DNA binding site [nucleotide binding] 768066008826 domain linker motif; other site 768066008827 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 768066008828 putative dimerization interface [polypeptide binding]; other site 768066008829 putative ligand binding site [chemical binding]; other site 768066008830 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 768066008831 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768066008832 dimerization interface [polypeptide binding]; other site 768066008833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066008834 dimer interface [polypeptide binding]; other site 768066008835 phosphorylation site [posttranslational modification] 768066008836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066008837 ATP binding site [chemical binding]; other site 768066008838 Mg2+ binding site [ion binding]; other site 768066008839 G-X-G motif; other site 768066008840 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 768066008841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066008842 active site 768066008843 phosphorylation site [posttranslational modification] 768066008844 intermolecular recognition site; other site 768066008845 dimerization interface [polypeptide binding]; other site 768066008846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066008847 DNA binding site [nucleotide binding] 768066008848 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768066008849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066008850 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 768066008851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066008852 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 768066008853 BCCT family transporter; Region: BCCT; cl00569 768066008854 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 768066008855 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 768066008856 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768066008857 active site 768066008858 P-loop; other site 768066008859 phosphorylation site [posttranslational modification] 768066008860 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 768066008861 active site 768066008862 P-loop; other site 768066008863 phosphorylation site [posttranslational modification] 768066008864 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 768066008865 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 768066008866 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 768066008867 putative substrate binding site [chemical binding]; other site 768066008868 putative ATP binding site [chemical binding]; other site 768066008869 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 768066008870 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768066008871 active site 768066008872 phosphorylation site [posttranslational modification] 768066008873 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768066008874 dimerization domain swap beta strand [polypeptide binding]; other site 768066008875 regulatory protein interface [polypeptide binding]; other site 768066008876 active site 768066008877 regulatory phosphorylation site [posttranslational modification]; other site 768066008878 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768066008879 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 768066008880 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768066008881 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768066008882 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 768066008883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 768066008884 DNA binding site [nucleotide binding] 768066008885 domain linker motif; other site 768066008886 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768066008887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066008888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066008889 dimer interface [polypeptide binding]; other site 768066008890 phosphorylation site [posttranslational modification] 768066008891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066008892 ATP binding site [chemical binding]; other site 768066008893 Mg2+ binding site [ion binding]; other site 768066008894 G-X-G motif; other site 768066008895 Response regulator receiver domain; Region: Response_reg; pfam00072 768066008896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066008897 active site 768066008898 phosphorylation site [posttranslational modification] 768066008899 intermolecular recognition site; other site 768066008900 dimerization interface [polypeptide binding]; other site 768066008901 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768066008902 putative binding surface; other site 768066008903 active site 768066008904 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 768066008905 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768066008906 Ligand Binding Site [chemical binding]; other site 768066008907 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 768066008908 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 768066008909 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 768066008910 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 768066008911 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 768066008912 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 768066008913 putative ADP-ribose binding site [chemical binding]; other site 768066008914 putative active site [active] 768066008915 DctM-like transporters; Region: DctM; pfam06808 768066008916 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066008917 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066008918 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066008919 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066008920 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 768066008921 EamA-like transporter family; Region: EamA; pfam00892 768066008922 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 768066008923 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 768066008924 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768066008925 active site 768066008926 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768066008927 YciI-like protein; Reviewed; Region: PRK11370 768066008928 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 768066008929 Uncharacterized conserved protein [Function unknown]; Region: COG4121 768066008930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066008931 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 768066008932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066008933 active site 768066008934 phosphorylation site [posttranslational modification] 768066008935 intermolecular recognition site; other site 768066008936 dimerization interface [polypeptide binding]; other site 768066008937 sensory histidine kinase DcuS; Provisional; Region: PRK11086 768066008938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066008939 ATP binding site [chemical binding]; other site 768066008940 Mg2+ binding site [ion binding]; other site 768066008941 G-X-G motif; other site 768066008942 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 768066008943 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 768066008944 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 768066008945 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 768066008946 nucleotide binding pocket [chemical binding]; other site 768066008947 K-X-D-G motif; other site 768066008948 catalytic site [active] 768066008949 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768066008950 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 768066008951 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 768066008952 Dimer interface [polypeptide binding]; other site 768066008953 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 768066008954 FtsZ protein binding site [polypeptide binding]; other site 768066008955 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 768066008956 Walker A/P-loop; other site 768066008957 ATP binding site [chemical binding]; other site 768066008958 Q-loop/lid; other site 768066008959 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 768066008960 ABC transporter signature motif; other site 768066008961 Walker B; other site 768066008962 D-loop; other site 768066008963 H-loop/switch region; other site 768066008964 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 768066008965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768066008966 binding surface 768066008967 TPR motif; other site 768066008968 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 768066008969 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 768066008970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768066008971 catalytic residues [active] 768066008972 central insert; other site 768066008973 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 768066008974 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 768066008975 Heme exporter protein D (CcmD); Region: CcmD; cl11475 768066008976 heme exporter protein CcmC; Region: ccmC; TIGR01191 768066008977 CcmB protein; Region: CcmB; cl17444 768066008978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066008979 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 768066008980 Walker A/P-loop; other site 768066008981 ATP binding site [chemical binding]; other site 768066008982 Q-loop/lid; other site 768066008983 ABC transporter signature motif; other site 768066008984 Walker B; other site 768066008985 D-loop; other site 768066008986 H-loop/switch region; other site 768066008987 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768066008988 Catalytic site [active] 768066008989 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 768066008990 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 768066008991 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 768066008992 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768066008993 putative acyl-acceptor binding pocket; other site 768066008994 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 768066008995 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 768066008996 oxaloacetate decarboxylase; Provisional; Region: PRK14040 768066008997 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 768066008998 active site 768066008999 catalytic residues [active] 768066009000 metal binding site [ion binding]; metal-binding site 768066009001 homodimer binding site [polypeptide binding]; other site 768066009002 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768066009003 carboxyltransferase (CT) interaction site; other site 768066009004 biotinylation site [posttranslational modification]; other site 768066009005 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 768066009006 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 768066009007 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768066009008 FMN binding site [chemical binding]; other site 768066009009 active site 768066009010 catalytic residues [active] 768066009011 substrate binding site [chemical binding]; other site 768066009012 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768066009013 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768066009014 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768066009015 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066009016 LysR family transcriptional regulator; Provisional; Region: PRK14997 768066009017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066009018 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768066009019 putative effector binding pocket; other site 768066009020 dimerization interface [polypeptide binding]; other site 768066009021 carbon storage regulator; Provisional; Region: PRK01712 768066009022 aspartate kinase; Reviewed; Region: PRK06635 768066009023 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 768066009024 putative nucleotide binding site [chemical binding]; other site 768066009025 putative catalytic residues [active] 768066009026 putative Mg ion binding site [ion binding]; other site 768066009027 putative aspartate binding site [chemical binding]; other site 768066009028 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 768066009029 putative allosteric regulatory site; other site 768066009030 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 768066009031 putative allosteric regulatory residue; other site 768066009032 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 768066009033 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 768066009034 motif 1; other site 768066009035 active site 768066009036 motif 2; other site 768066009037 motif 3; other site 768066009038 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768066009039 DHHA1 domain; Region: DHHA1; pfam02272 768066009040 recombination regulator RecX; Reviewed; Region: recX; PRK00117 768066009041 recombinase A; Provisional; Region: recA; PRK09354 768066009042 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 768066009043 hexamer interface [polypeptide binding]; other site 768066009044 Walker A motif; other site 768066009045 ATP binding site [chemical binding]; other site 768066009046 Walker B motif; other site 768066009047 Competence-damaged protein; Region: CinA; pfam02464 768066009048 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 768066009049 MutS domain I; Region: MutS_I; pfam01624 768066009050 MutS domain II; Region: MutS_II; pfam05188 768066009051 MutS domain III; Region: MutS_III; pfam05192 768066009052 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 768066009053 Walker A/P-loop; other site 768066009054 ATP binding site [chemical binding]; other site 768066009055 Q-loop/lid; other site 768066009056 ABC transporter signature motif; other site 768066009057 Walker B; other site 768066009058 D-loop; other site 768066009059 H-loop/switch region; other site 768066009060 Ferredoxin [Energy production and conversion]; Region: COG1146 768066009061 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 768066009062 enolase; Provisional; Region: eno; PRK00077 768066009063 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 768066009064 dimer interface [polypeptide binding]; other site 768066009065 metal binding site [ion binding]; metal-binding site 768066009066 substrate binding pocket [chemical binding]; other site 768066009067 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768066009068 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 768066009069 CTP synthetase; Validated; Region: pyrG; PRK05380 768066009070 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 768066009071 Catalytic site [active] 768066009072 active site 768066009073 UTP binding site [chemical binding]; other site 768066009074 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 768066009075 active site 768066009076 putative oxyanion hole; other site 768066009077 catalytic triad [active] 768066009078 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 768066009079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066009080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066009081 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 768066009082 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 768066009083 active site 768066009084 dimer interface [polypeptide binding]; other site 768066009085 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 768066009086 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768066009087 active site 768066009088 FMN binding site [chemical binding]; other site 768066009089 substrate binding site [chemical binding]; other site 768066009090 3Fe-4S cluster binding site [ion binding]; other site 768066009091 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 768066009092 domain interface; other site 768066009093 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 768066009094 active site 768066009095 dimer interface [polypeptide binding]; other site 768066009096 metal binding site [ion binding]; metal-binding site 768066009097 shikimate kinase; Reviewed; Region: aroK; PRK00131 768066009098 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768066009099 ADP binding site [chemical binding]; other site 768066009100 magnesium binding site [ion binding]; other site 768066009101 putative shikimate binding site; other site 768066009102 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 768066009103 Secretin and TonB N terminus short domain; Region: STN; smart00965 768066009104 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768066009105 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 768066009106 Pilus assembly protein, PilP; Region: PilP; pfam04351 768066009107 Pilus assembly protein, PilO; Region: PilO; cl01234 768066009108 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 768066009109 Competence protein A; Region: Competence_A; pfam11104 768066009110 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 768066009111 Transglycosylase; Region: Transgly; pfam00912 768066009112 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768066009113 Protein of unknown function, DUF481; Region: DUF481; pfam04338 768066009114 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768066009115 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 768066009116 putative NAD(P) binding site [chemical binding]; other site 768066009117 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 768066009118 primosome assembly protein PriA; Validated; Region: PRK05580 768066009119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768066009120 ATP binding site [chemical binding]; other site 768066009121 putative Mg++ binding site [ion binding]; other site 768066009122 helicase superfamily c-terminal domain; Region: HELICc; smart00490 768066009123 ATP-binding site [chemical binding]; other site 768066009124 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 768066009125 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 768066009126 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768066009127 active site 768066009128 HIGH motif; other site 768066009129 KMSK motif region; other site 768066009130 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768066009131 tRNA binding surface [nucleotide binding]; other site 768066009132 anticodon binding site; other site 768066009133 Sporulation related domain; Region: SPOR; pfam05036 768066009134 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 768066009135 active site 768066009136 HslU subunit interaction site [polypeptide binding]; other site 768066009137 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 768066009138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066009139 Walker A motif; other site 768066009140 ATP binding site [chemical binding]; other site 768066009141 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 768066009142 Walker B motif; other site 768066009143 arginine finger; other site 768066009144 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768066009145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 768066009146 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 768066009147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066009148 S-adenosylmethionine binding site [chemical binding]; other site 768066009149 SCP-2 sterol transfer family; Region: SCP2; pfam02036 768066009150 ABC1 family; Region: ABC1; cl17513 768066009151 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 768066009152 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 768066009153 metal binding site [ion binding]; metal-binding site 768066009154 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 768066009155 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 768066009156 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 768066009157 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 768066009158 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 768066009159 conserved cys residue [active] 768066009160 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 768066009161 dimer interface [polypeptide binding]; other site 768066009162 active site 768066009163 aspartate-rich active site metal binding site; other site 768066009164 allosteric magnesium binding site [ion binding]; other site 768066009165 Schiff base residues; other site 768066009166 polyphosphate kinase; Provisional; Region: PRK05443 768066009167 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 768066009168 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 768066009169 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 768066009170 putative domain interface [polypeptide binding]; other site 768066009171 putative active site [active] 768066009172 catalytic site [active] 768066009173 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 768066009174 putative domain interface [polypeptide binding]; other site 768066009175 putative active site [active] 768066009176 catalytic site [active] 768066009177 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 768066009178 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768066009179 dihydromonapterin reductase; Provisional; Region: PRK06483 768066009180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066009181 NAD(P) binding site [chemical binding]; other site 768066009182 active site 768066009183 FMN reductase; Validated; Region: fre; PRK08051 768066009184 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 768066009185 FAD binding pocket [chemical binding]; other site 768066009186 FAD binding motif [chemical binding]; other site 768066009187 phosphate binding motif [ion binding]; other site 768066009188 beta-alpha-beta structure motif; other site 768066009189 NAD binding pocket [chemical binding]; other site 768066009190 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 768066009191 transcription termination factor Rho; Provisional; Region: rho; PRK09376 768066009192 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 768066009193 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 768066009194 RNA binding site [nucleotide binding]; other site 768066009195 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 768066009196 multimer interface [polypeptide binding]; other site 768066009197 Walker A motif; other site 768066009198 ATP binding site [chemical binding]; other site 768066009199 Walker B motif; other site 768066009200 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 768066009201 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768066009202 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 768066009203 Ligand Binding Site [chemical binding]; other site 768066009204 TilS substrate binding domain; Region: TilS; pfam09179 768066009205 TilS substrate C-terminal domain; Region: TilS_C; smart00977 768066009206 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 768066009207 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 768066009208 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 768066009209 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 768066009210 putative active site [active] 768066009211 putative PHP Thumb interface [polypeptide binding]; other site 768066009212 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 768066009213 generic binding surface II; other site 768066009214 generic binding surface I; other site 768066009215 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 768066009216 RNA/DNA hybrid binding site [nucleotide binding]; other site 768066009217 active site 768066009218 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 768066009219 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 768066009220 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768066009221 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768066009222 active site 768066009223 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768066009224 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 768066009225 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 768066009226 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 768066009227 trimer interface [polypeptide binding]; other site 768066009228 active site 768066009229 UDP-GlcNAc binding site [chemical binding]; other site 768066009230 lipid binding site [chemical binding]; lipid-binding site 768066009231 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 768066009232 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 768066009233 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768066009234 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768066009235 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768066009236 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768066009237 Surface antigen; Region: Bac_surface_Ag; pfam01103 768066009238 zinc metallopeptidase RseP; Provisional; Region: PRK10779 768066009239 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768066009240 active site 768066009241 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768066009242 protein binding site [polypeptide binding]; other site 768066009243 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768066009244 protein binding site [polypeptide binding]; other site 768066009245 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768066009246 putative substrate binding region [chemical binding]; other site 768066009247 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 768066009248 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 768066009249 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 768066009250 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 768066009251 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 768066009252 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 768066009253 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 768066009254 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 768066009255 catalytic residue [active] 768066009256 putative FPP diphosphate binding site; other site 768066009257 putative FPP binding hydrophobic cleft; other site 768066009258 dimer interface [polypeptide binding]; other site 768066009259 putative IPP diphosphate binding site; other site 768066009260 ribosome recycling factor; Reviewed; Region: frr; PRK00083 768066009261 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 768066009262 hinge region; other site 768066009263 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 768066009264 putative nucleotide binding site [chemical binding]; other site 768066009265 uridine monophosphate binding site [chemical binding]; other site 768066009266 homohexameric interface [polypeptide binding]; other site 768066009267 elongation factor Ts; Provisional; Region: tsf; PRK09377 768066009268 UBA/TS-N domain; Region: UBA; pfam00627 768066009269 Elongation factor TS; Region: EF_TS; pfam00889 768066009270 Elongation factor TS; Region: EF_TS; pfam00889 768066009271 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 768066009272 rRNA interaction site [nucleotide binding]; other site 768066009273 S8 interaction site; other site 768066009274 putative laminin-1 binding site; other site 768066009275 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768066009276 active site 768066009277 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 768066009278 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768066009279 metal binding triad; other site 768066009280 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768066009281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768066009282 Zn2+ binding site [ion binding]; other site 768066009283 Mg2+ binding site [ion binding]; other site 768066009284 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 768066009285 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 768066009286 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 768066009287 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066009288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066009289 homodimer interface [polypeptide binding]; other site 768066009290 catalytic residue [active] 768066009291 ArsC family; Region: ArsC; pfam03960 768066009292 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 768066009293 putative catalytic residues [active] 768066009294 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 768066009295 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 768066009296 putative trimer interface [polypeptide binding]; other site 768066009297 putative CoA binding site [chemical binding]; other site 768066009298 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 768066009299 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 768066009300 metal binding site [ion binding]; metal-binding site 768066009301 dimer interface [polypeptide binding]; other site 768066009302 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768066009303 DNA-binding site [nucleotide binding]; DNA binding site 768066009304 RNA-binding motif; other site 768066009305 Region: SlyX; pfam04102 768066009306 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 768066009307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066009308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066009309 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 768066009310 aconitate hydratase; Validated; Region: PRK09277 768066009311 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 768066009312 substrate binding site [chemical binding]; other site 768066009313 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 768066009314 ligand binding site [chemical binding]; other site 768066009315 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 768066009316 substrate binding site [chemical binding]; other site 768066009317 malate dehydrogenase; Provisional; Region: PRK13529 768066009318 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768066009319 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 768066009320 NAD(P) binding site [chemical binding]; other site 768066009321 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768066009322 active site 768066009323 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 768066009324 HIGH motif; other site 768066009325 dimer interface [polypeptide binding]; other site 768066009326 KMSKS motif; other site 768066009327 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 768066009328 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 768066009329 hexamer interface [polypeptide binding]; other site 768066009330 ligand binding site [chemical binding]; other site 768066009331 putative active site [active] 768066009332 NAD(P) binding site [chemical binding]; other site 768066009333 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768066009334 active site 768066009335 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 768066009336 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 768066009337 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 768066009338 putative RNA binding site [nucleotide binding]; other site 768066009339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066009340 S-adenosylmethionine binding site [chemical binding]; other site 768066009341 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 768066009342 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 768066009343 DNA binding site [nucleotide binding] 768066009344 catalytic residue [active] 768066009345 H2TH interface [polypeptide binding]; other site 768066009346 putative catalytic residues [active] 768066009347 turnover-facilitating residue; other site 768066009348 intercalation triad [nucleotide binding]; other site 768066009349 8OG recognition residue [nucleotide binding]; other site 768066009350 putative reading head residues; other site 768066009351 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 768066009352 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768066009353 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 768066009354 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 768066009355 hypothetical protein; Reviewed; Region: PRK00024 768066009356 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 768066009357 MPN+ (JAMM) motif; other site 768066009358 Zinc-binding site [ion binding]; other site 768066009359 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 768066009360 Flavoprotein; Region: Flavoprotein; pfam02441 768066009361 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 768066009362 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768066009363 trimer interface [polypeptide binding]; other site 768066009364 active site 768066009365 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 768066009366 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 768066009367 active site 768066009368 substrate binding site [chemical binding]; other site 768066009369 metal binding site [ion binding]; metal-binding site 768066009370 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 768066009371 feedback inhibition sensing region; other site 768066009372 homohexameric interface [polypeptide binding]; other site 768066009373 nucleotide binding site [chemical binding]; other site 768066009374 N-acetyl-L-glutamate binding site [chemical binding]; other site 768066009375 division inhibitor protein; Provisional; Region: slmA; PRK09480 768066009376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066009377 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 768066009378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768066009379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768066009380 DNA binding residues [nucleotide binding] 768066009381 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 768066009382 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 768066009383 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 768066009384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066009385 Walker A/P-loop; other site 768066009386 ATP binding site [chemical binding]; other site 768066009387 Q-loop/lid; other site 768066009388 ABC transporter signature motif; other site 768066009389 Walker B; other site 768066009390 D-loop; other site 768066009391 H-loop/switch region; other site 768066009392 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 768066009393 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 768066009394 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768066009395 P loop; other site 768066009396 GTP binding site [chemical binding]; other site 768066009397 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 768066009398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066009399 S-adenosylmethionine binding site [chemical binding]; other site 768066009400 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768066009401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768066009402 Coenzyme A binding pocket [chemical binding]; other site 768066009403 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 768066009404 BolA-like protein; Region: BolA; cl00386 768066009405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066009406 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768066009407 putative substrate translocation pore; other site 768066009408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066009409 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 768066009410 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 768066009411 dimer interface [polypeptide binding]; other site 768066009412 putative anticodon binding site; other site 768066009413 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 768066009414 motif 1; other site 768066009415 active site 768066009416 motif 2; other site 768066009417 motif 3; other site 768066009418 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768066009419 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 768066009420 RF-1 domain; Region: RF-1; pfam00472 768066009421 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768066009422 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 768066009423 peptide binding site [polypeptide binding]; other site 768066009424 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 768066009425 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 768066009426 peptide binding site [polypeptide binding]; other site 768066009427 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 768066009428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066009429 dimer interface [polypeptide binding]; other site 768066009430 conserved gate region; other site 768066009431 putative PBP binding loops; other site 768066009432 ABC-ATPase subunit interface; other site 768066009433 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 768066009434 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 768066009435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066009436 dimer interface [polypeptide binding]; other site 768066009437 conserved gate region; other site 768066009438 ABC-ATPase subunit interface; other site 768066009439 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 768066009440 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768066009441 Walker A/P-loop; other site 768066009442 ATP binding site [chemical binding]; other site 768066009443 Q-loop/lid; other site 768066009444 ABC transporter signature motif; other site 768066009445 Walker B; other site 768066009446 D-loop; other site 768066009447 H-loop/switch region; other site 768066009448 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 768066009449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768066009450 Walker A/P-loop; other site 768066009451 ATP binding site [chemical binding]; other site 768066009452 Q-loop/lid; other site 768066009453 ABC transporter signature motif; other site 768066009454 Walker B; other site 768066009455 D-loop; other site 768066009456 H-loop/switch region; other site 768066009457 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768066009458 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 768066009459 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 768066009460 trimer interface [polypeptide binding]; other site 768066009461 eyelet of channel; other site 768066009462 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 768066009463 Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787 768066009464 DNA binding residues [nucleotide binding] 768066009465 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 768066009466 dimer interface [polypeptide binding]; other site 768066009467 copper exporting ATPase; Provisional; Region: copA; PRK10671 768066009468 Heavy-metal-associated domain; Region: HMA; pfam00403 768066009469 metal-binding site [ion binding] 768066009470 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768066009471 metal-binding site [ion binding] 768066009472 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 768066009473 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768066009474 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066009475 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 768066009476 putative metal binding site [ion binding]; other site 768066009477 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 768066009478 DHH family; Region: DHH; pfam01368 768066009479 DHHA1 domain; Region: DHHA1; pfam02272 768066009480 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 768066009481 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 768066009482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066009483 catalytic residue [active] 768066009484 homoserine dehydrogenase; Provisional; Region: PRK06349 768066009485 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768066009486 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768066009487 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 768066009488 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768066009489 dimerization domain [polypeptide binding]; other site 768066009490 dimer interface [polypeptide binding]; other site 768066009491 catalytic residues [active] 768066009492 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 768066009493 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768066009494 active site 768066009495 DNA binding site [nucleotide binding] 768066009496 Int/Topo IB signature motif; other site 768066009497 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 768066009498 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 768066009499 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 768066009500 RimM N-terminal domain; Region: RimM; pfam01782 768066009501 PRC-barrel domain; Region: PRC; pfam05239 768066009502 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 768066009503 signal recognition particle protein; Provisional; Region: PRK10867 768066009504 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 768066009505 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768066009506 P loop; other site 768066009507 GTP binding site [chemical binding]; other site 768066009508 Signal peptide binding domain; Region: SRP_SPB; pfam02978 768066009509 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768066009510 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 768066009511 Domain of unknown function DUF21; Region: DUF21; pfam01595 768066009512 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768066009513 Transporter associated domain; Region: CorC_HlyC; smart01091 768066009514 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768066009515 putative acyl-acceptor binding pocket; other site 768066009516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066009517 WHG domain; Region: WHG; pfam13305 768066009518 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 768066009519 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 768066009520 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768066009521 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768066009522 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768066009523 exonuclease I; Provisional; Region: sbcB; PRK11779 768066009524 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 768066009525 active site 768066009526 catalytic site [active] 768066009527 substrate binding site [chemical binding]; other site 768066009528 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 768066009529 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 768066009530 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 768066009531 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 768066009532 Switch I; other site 768066009533 Switch II; other site 768066009534 septum formation inhibitor; Reviewed; Region: minC; PRK00339 768066009535 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 768066009536 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 768066009537 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 768066009538 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 768066009539 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 768066009540 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768066009541 homotetramer interface [polypeptide binding]; other site 768066009542 NAD(P) binding site [chemical binding]; other site 768066009543 homodimer interface [polypeptide binding]; other site 768066009544 active site 768066009545 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 768066009546 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 768066009547 META domain; Region: META; cl01245 768066009548 DoxX; Region: DoxX; pfam07681 768066009549 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 768066009550 dimer interface [polypeptide binding]; other site 768066009551 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066009552 active site 768066009553 metal binding site [ion binding]; metal-binding site 768066009554 glutathione binding site [chemical binding]; other site 768066009555 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 768066009556 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 768066009557 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768066009558 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768066009559 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 768066009560 Predicted membrane protein [Function unknown]; Region: COG3650 768066009561 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 768066009562 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 768066009563 THF binding site; other site 768066009564 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768066009565 substrate binding site [chemical binding]; other site 768066009566 THF binding site; other site 768066009567 zinc-binding site [ion binding]; other site 768066009568 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 768066009569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066009570 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 768066009571 putative dimerization interface [polypeptide binding]; other site 768066009572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768066009573 dimerization interface [polypeptide binding]; other site 768066009574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066009575 dimer interface [polypeptide binding]; other site 768066009576 phosphorylation site [posttranslational modification] 768066009577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066009578 ATP binding site [chemical binding]; other site 768066009579 Mg2+ binding site [ion binding]; other site 768066009580 G-X-G motif; other site 768066009581 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 768066009582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066009583 active site 768066009584 phosphorylation site [posttranslational modification] 768066009585 intermolecular recognition site; other site 768066009586 dimerization interface [polypeptide binding]; other site 768066009587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066009588 DNA binding site [nucleotide binding] 768066009589 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 768066009590 ATP cone domain; Region: ATP-cone; pfam03477 768066009591 ATP cone domain; Region: ATP-cone; pfam03477 768066009592 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768066009593 active site 768066009594 dimer interface [polypeptide binding]; other site 768066009595 catalytic residues [active] 768066009596 effector binding site; other site 768066009597 R2 peptide binding site; other site 768066009598 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768066009599 dimer interface [polypeptide binding]; other site 768066009600 putative radical transfer pathway; other site 768066009601 diiron center [ion binding]; other site 768066009602 tyrosyl radical; other site 768066009603 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 768066009604 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768066009605 N-terminal plug; other site 768066009606 ligand-binding site [chemical binding]; other site 768066009607 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 768066009608 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 768066009609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066009610 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768066009611 DNA binding site [nucleotide binding] 768066009612 active site 768066009613 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 768066009614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066009615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066009616 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 768066009617 putative effector binding pocket; other site 768066009618 putative dimerization interface [polypeptide binding]; other site 768066009619 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 768066009620 short chain dehydrogenase; Provisional; Region: PRK12744 768066009621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066009622 NAD(P) binding site [chemical binding]; other site 768066009623 active site 768066009624 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768066009625 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066009626 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768066009627 Protein export membrane protein; Region: SecD_SecF; cl14618 768066009628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066009629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066009630 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 768066009631 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 768066009632 nudix motif; other site 768066009633 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 768066009634 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 768066009635 TrkA-N domain; Region: TrkA_N; pfam02254 768066009636 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 768066009637 DEAD-like helicases superfamily; Region: DEXDc2; smart00488 768066009638 DEAD_2; Region: DEAD_2; pfam06733 768066009639 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768066009640 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 768066009641 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 768066009642 catalytic motif [active] 768066009643 Catalytic residue [active] 768066009644 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 768066009645 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 768066009646 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 768066009647 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 768066009648 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 768066009649 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 768066009650 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 768066009651 Mg++ binding site [ion binding]; other site 768066009652 transcriptional regulator NarP; Provisional; Region: PRK10403 768066009653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768066009654 DNA binding residues [nucleotide binding] 768066009655 dimerization interface [polypeptide binding]; other site 768066009656 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 768066009657 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 768066009658 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 768066009659 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 768066009660 active site 768066009661 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 768066009662 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 768066009663 NAD(P) binding site [chemical binding]; other site 768066009664 catalytic residues [active] 768066009665 allantoate amidohydrolase; Reviewed; Region: PRK12893 768066009666 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 768066009667 active site 768066009668 metal binding site [ion binding]; metal-binding site 768066009669 dimer interface [polypeptide binding]; other site 768066009670 hypothetical protein; Provisional; Region: PRK07036 768066009671 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066009672 inhibitor-cofactor binding pocket; inhibition site 768066009673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066009674 catalytic residue [active] 768066009675 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 768066009676 agmatine deiminase; Provisional; Region: PRK13551 768066009677 agmatine deiminase; Region: agmatine_aguA; TIGR03380 768066009678 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 768066009679 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 768066009680 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 768066009681 Ion transport protein; Region: Ion_trans; pfam00520 768066009682 Ion channel; Region: Ion_trans_2; pfam07885 768066009683 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066009684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066009685 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 768066009686 dimerization interface [polypeptide binding]; other site 768066009687 substrate binding pocket [chemical binding]; other site 768066009688 Peptidase family M48; Region: Peptidase_M48; pfam01435 768066009689 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 768066009690 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 768066009691 Cupin domain; Region: Cupin_2; cl17218 768066009692 Helix-turn-helix domain; Region: HTH_18; pfam12833 768066009693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066009694 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 768066009695 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768066009696 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 768066009697 NAD(P) binding site [chemical binding]; other site 768066009698 catalytic residues [active] 768066009699 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066009700 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066009701 benzoylformate decarboxylase; Reviewed; Region: PRK07092 768066009702 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768066009703 PYR/PP interface [polypeptide binding]; other site 768066009704 dimer interface [polypeptide binding]; other site 768066009705 TPP binding site [chemical binding]; other site 768066009706 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768066009707 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 768066009708 TPP-binding site [chemical binding]; other site 768066009709 dimer interface [polypeptide binding]; other site 768066009710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066009711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066009712 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 768066009713 substrate binding pocket [chemical binding]; other site 768066009714 dimerization interface [polypeptide binding]; other site 768066009715 DctM-like transporters; Region: DctM; pfam06808 768066009716 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066009717 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066009718 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066009719 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 768066009720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768066009721 DNA-binding site [nucleotide binding]; DNA binding site 768066009722 FCD domain; Region: FCD; pfam07729 768066009723 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 768066009724 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 768066009725 iron-sulfur cluster [ion binding]; other site 768066009726 [2Fe-2S] cluster binding site [ion binding]; other site 768066009727 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 768066009728 alpha subunit interface [polypeptide binding]; other site 768066009729 active site 768066009730 substrate binding site [chemical binding]; other site 768066009731 Fe binding site [ion binding]; other site 768066009732 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 768066009733 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 768066009734 FMN-binding pocket [chemical binding]; other site 768066009735 flavin binding motif; other site 768066009736 phosphate binding motif [ion binding]; other site 768066009737 beta-alpha-beta structure motif; other site 768066009738 NAD binding pocket [chemical binding]; other site 768066009739 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768066009740 catalytic loop [active] 768066009741 iron binding site [ion binding]; other site 768066009742 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066009743 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066009744 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 768066009745 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768066009746 substrate binding site [chemical binding]; other site 768066009747 oxyanion hole (OAH) forming residues; other site 768066009748 trimer interface [polypeptide binding]; other site 768066009749 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768066009750 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 768066009751 NAD binding site [chemical binding]; other site 768066009752 homodimer interface [polypeptide binding]; other site 768066009753 homotetramer interface [polypeptide binding]; other site 768066009754 active site 768066009755 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 768066009756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768066009757 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768066009758 active site 768066009759 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 768066009760 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768066009761 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 768066009762 dimer interface [polypeptide binding]; other site 768066009763 active site 768066009764 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 768066009765 Coenzyme A transferase; Region: CoA_trans; smart00882 768066009766 Coenzyme A transferase; Region: CoA_trans; cl17247 768066009767 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768066009768 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066009769 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066009770 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768066009771 active site 768066009772 feruloyl-CoA synthase; Reviewed; Region: PRK08180 768066009773 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 768066009774 acyl-activating enzyme (AAE) consensus motif; other site 768066009775 putative AMP binding site [chemical binding]; other site 768066009776 putative active site [active] 768066009777 putative CoA binding site [chemical binding]; other site 768066009778 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 768066009779 MarR family; Region: MarR; pfam01047 768066009780 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 768066009781 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 768066009782 heterodimer interface [polypeptide binding]; other site 768066009783 active site 768066009784 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 768066009785 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 768066009786 active site 768066009787 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 768066009788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066009789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066009790 dimerization interface [polypeptide binding]; other site 768066009791 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 768066009792 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 768066009793 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 768066009794 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 768066009795 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768066009796 dimer interface [polypeptide binding]; other site 768066009797 active site 768066009798 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 768066009799 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 768066009800 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 768066009801 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 768066009802 tetramer interface [polypeptide binding]; other site 768066009803 active site 768066009804 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 768066009805 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768066009806 Bacterial transcriptional regulator; Region: IclR; pfam01614 768066009807 Predicted permeases [General function prediction only]; Region: COG0679 768066009808 transketolase; Reviewed; Region: PRK12753 768066009809 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768066009810 TPP-binding site [chemical binding]; other site 768066009811 dimer interface [polypeptide binding]; other site 768066009812 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768066009813 PYR/PP interface [polypeptide binding]; other site 768066009814 dimer interface [polypeptide binding]; other site 768066009815 TPP binding site [chemical binding]; other site 768066009816 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768066009817 transaldolase-like protein; Provisional; Region: PTZ00411 768066009818 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 768066009819 active site 768066009820 dimer interface [polypeptide binding]; other site 768066009821 catalytic residue [active] 768066009822 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768066009823 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768066009824 TM-ABC transporter signature motif; other site 768066009825 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 768066009826 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768066009827 Walker A/P-loop; other site 768066009828 ATP binding site [chemical binding]; other site 768066009829 Q-loop/lid; other site 768066009830 ABC transporter signature motif; other site 768066009831 Walker B; other site 768066009832 D-loop; other site 768066009833 H-loop/switch region; other site 768066009834 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768066009835 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768066009836 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768066009837 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 768066009838 MarR family; Region: MarR_2; pfam12802 768066009839 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 768066009840 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 768066009841 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 768066009842 N- and C-terminal domain interface [polypeptide binding]; other site 768066009843 active site 768066009844 MgATP binding site [chemical binding]; other site 768066009845 catalytic site [active] 768066009846 metal binding site [ion binding]; metal-binding site 768066009847 putative homotetramer interface [polypeptide binding]; other site 768066009848 putative homodimer interface [polypeptide binding]; other site 768066009849 glycerol binding site [chemical binding]; other site 768066009850 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 768066009851 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768066009852 PYR/PP interface [polypeptide binding]; other site 768066009853 dimer interface [polypeptide binding]; other site 768066009854 TPP binding site [chemical binding]; other site 768066009855 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768066009856 transketolase; Reviewed; Region: PRK05899 768066009857 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768066009858 TPP-binding site [chemical binding]; other site 768066009859 dimer interface [polypeptide binding]; other site 768066009860 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 768066009861 Dehydroquinase class II; Region: DHquinase_II; pfam01220 768066009862 trimer interface [polypeptide binding]; other site 768066009863 active site 768066009864 dimer interface [polypeptide binding]; other site 768066009865 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 768066009866 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768066009867 metal binding triad; other site 768066009868 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768066009869 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768066009870 metal binding triad; other site 768066009871 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768066009872 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 768066009873 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 768066009874 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 768066009875 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768066009876 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 768066009877 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066009878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066009879 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 768066009880 dimerization interface [polypeptide binding]; other site 768066009881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066009882 S-adenosylmethionine binding site [chemical binding]; other site 768066009883 3-oxoacyl-[acyl-carrier-protein] synthase; Region: PLN02836 768066009884 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 768066009885 active site 768066009886 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 768066009887 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 768066009888 active site 768066009889 (T/H)XGH motif; other site 768066009890 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768066009891 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 768066009892 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 768066009893 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 768066009894 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768066009895 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 768066009896 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 768066009897 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 768066009898 dimerization interface [polypeptide binding]; other site 768066009899 DPS ferroxidase diiron center [ion binding]; other site 768066009900 ion pore; other site 768066009901 RmuC family; Region: RmuC; pfam02646 768066009902 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 768066009903 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 768066009904 metal binding site [ion binding]; metal-binding site 768066009905 dimer interface [polypeptide binding]; other site 768066009906 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 768066009907 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 768066009908 Helicase; Region: Helicase_RecD; pfam05127 768066009909 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 768066009910 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 768066009911 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066009912 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 768066009913 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 768066009914 DctM-like transporters; Region: DctM; pfam06808 768066009915 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 768066009916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066009917 dimer interface [polypeptide binding]; other site 768066009918 conserved gate region; other site 768066009919 putative PBP binding loops; other site 768066009920 ABC-ATPase subunit interface; other site 768066009921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 768066009922 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 768066009923 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 768066009924 Walker A/P-loop; other site 768066009925 ATP binding site [chemical binding]; other site 768066009926 Q-loop/lid; other site 768066009927 ABC transporter signature motif; other site 768066009928 Walker B; other site 768066009929 D-loop; other site 768066009930 H-loop/switch region; other site 768066009931 TOBE domain; Region: TOBE_2; pfam08402 768066009932 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 768066009933 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 768066009934 DNA polymerase I; Provisional; Region: PRK05755 768066009935 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768066009936 active site 768066009937 metal binding site 1 [ion binding]; metal-binding site 768066009938 putative 5' ssDNA interaction site; other site 768066009939 metal binding site 3; metal-binding site 768066009940 metal binding site 2 [ion binding]; metal-binding site 768066009941 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768066009942 putative DNA binding site [nucleotide binding]; other site 768066009943 putative metal binding site [ion binding]; other site 768066009944 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 768066009945 active site 768066009946 catalytic site [active] 768066009947 substrate binding site [chemical binding]; other site 768066009948 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 768066009949 active site 768066009950 DNA binding site [nucleotide binding] 768066009951 catalytic site [active] 768066009952 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 768066009953 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 768066009954 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 768066009955 putative active site [active] 768066009956 putative substrate binding site [chemical binding]; other site 768066009957 ATP binding site [chemical binding]; other site 768066009958 arginine decarboxylase; Provisional; Region: PRK05354 768066009959 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 768066009960 dimer interface [polypeptide binding]; other site 768066009961 active site 768066009962 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768066009963 catalytic residues [active] 768066009964 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 768066009965 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 768066009966 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 768066009967 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 768066009968 Trp docking motif [polypeptide binding]; other site 768066009969 putative active site [active] 768066009970 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 768066009971 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768066009972 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 768066009973 YodA lipocalin-like domain; Region: YodA; pfam09223 768066009974 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768066009975 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 768066009976 metal binding site [ion binding]; metal-binding site 768066009977 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 768066009978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066009979 Walker A/P-loop; other site 768066009980 ATP binding site [chemical binding]; other site 768066009981 Q-loop/lid; other site 768066009982 ABC transporter signature motif; other site 768066009983 Walker B; other site 768066009984 D-loop; other site 768066009985 H-loop/switch region; other site 768066009986 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768066009987 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768066009988 ABC-ATPase subunit interface; other site 768066009989 dimer interface [polypeptide binding]; other site 768066009990 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 768066009991 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768066009992 substrate binding site [chemical binding]; other site 768066009993 glutamase interaction surface [polypeptide binding]; other site 768066009994 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 768066009995 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768066009996 catalytic residues [active] 768066009997 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 768066009998 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 768066009999 putative active site [active] 768066010000 oxyanion strand; other site 768066010001 catalytic triad [active] 768066010002 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 768066010003 putative active site pocket [active] 768066010004 4-fold oligomerization interface [polypeptide binding]; other site 768066010005 metal binding residues [ion binding]; metal-binding site 768066010006 3-fold/trimer interface [polypeptide binding]; other site 768066010007 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 768066010008 AsmA family; Region: AsmA; pfam05170 768066010009 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 768066010010 adenine DNA glycosylase; Provisional; Region: PRK10880 768066010011 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768066010012 minor groove reading motif; other site 768066010013 helix-hairpin-helix signature motif; other site 768066010014 substrate binding pocket [chemical binding]; other site 768066010015 active site 768066010016 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 768066010017 DNA binding and oxoG recognition site [nucleotide binding] 768066010018 oxidative damage protection protein; Provisional; Region: PRK05408 768066010019 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768066010020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768066010021 Magnesium ion binding site [ion binding]; other site 768066010022 replicative DNA helicase; Region: DnaB; TIGR00665 768066010023 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768066010024 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768066010025 Walker A motif; other site 768066010026 ATP binding site [chemical binding]; other site 768066010027 Walker B motif; other site 768066010028 DNA binding loops [nucleotide binding] 768066010029 anthranilate synthase component I; Provisional; Region: PRK13570 768066010030 HD domain; Region: HD_3; cl17350 768066010031 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 768066010032 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 768066010033 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 768066010034 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 768066010035 ParB-like nuclease domain; Region: ParBc; pfam02195 768066010036 Protein of unknown function (DUF1509); Region: DUF1509; pfam07420 768066010037 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 768066010038 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 768066010039 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 768066010040 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768066010041 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768066010042 ssDNA binding site [nucleotide binding]; other site 768066010043 dimer interface [polypeptide binding]; other site 768066010044 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 768066010045 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768066010046 Bacterial PH domain; Region: DUF304; pfam03703 768066010047 DNA topoisomerase III; Provisional; Region: PRK07726 768066010048 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 768066010049 active site 768066010050 putative interdomain interaction site [polypeptide binding]; other site 768066010051 putative metal-binding site [ion binding]; other site 768066010052 putative nucleotide binding site [chemical binding]; other site 768066010053 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768066010054 domain I; other site 768066010055 DNA binding groove [nucleotide binding] 768066010056 phosphate binding site [ion binding]; other site 768066010057 domain II; other site 768066010058 domain III; other site 768066010059 nucleotide binding site [chemical binding]; other site 768066010060 catalytic site [active] 768066010061 domain IV; other site 768066010062 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768066010063 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 768066010064 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 768066010065 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 768066010066 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 768066010067 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 768066010068 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 768066010069 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 768066010070 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 768066010071 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 768066010072 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 768066010073 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 768066010074 Protein of unknown function (DUF2976); Region: DUF2976; pfam11190 768066010075 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 768066010076 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 768066010077 Protein of unknown function (DUF3438); Region: DUF3438; cl13372 768066010078 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 768066010079 Protein of unknown function (DUF972); Region: DUF972; pfam06156 768066010080 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 768066010081 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 768066010082 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 768066010083 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768066010084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066010085 Walker A/P-loop; other site 768066010086 ATP binding site [chemical binding]; other site 768066010087 Q-loop/lid; other site 768066010088 ABC transporter signature motif; other site 768066010089 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 768066010090 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 768066010091 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 768066010092 dimerization domain [polypeptide binding]; other site 768066010093 dimer interface [polypeptide binding]; other site 768066010094 catalytic residues [active] 768066010095 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 768066010096 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 768066010097 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 768066010098 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 768066010099 hypothetical protein; Provisional; Region: PRK09956 768066010100 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 768066010101 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768066010102 IHF dimer interface [polypeptide binding]; other site 768066010103 IHF - DNA interface [nucleotide binding]; other site 768066010104 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 768066010105 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 768066010106 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 768066010107 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 768066010108 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 768066010109 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 768066010110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768066010111 active site 768066010112 DNA binding site [nucleotide binding] 768066010113 Int/Topo IB signature motif; other site 768066010114 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 768066010115 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 768066010116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768066010117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768066010118 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 768066010119 Amidase; Region: Amidase; cl11426 768066010120 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768066010121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768066010122 non-specific DNA binding site [nucleotide binding]; other site 768066010123 salt bridge; other site 768066010124 sequence-specific DNA binding site [nucleotide binding]; other site 768066010125 Cupin domain; Region: Cupin_2; pfam07883 768066010126 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 768066010127 intersubunit interface [polypeptide binding]; other site 768066010128 active site 768066010129 Zn2+ binding site [ion binding]; other site 768066010130 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 768066010131 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 768066010132 inhibitor site; inhibition site 768066010133 active site 768066010134 dimer interface [polypeptide binding]; other site 768066010135 catalytic residue [active] 768066010136 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 768066010137 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 768066010138 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 768066010139 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 768066010140 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 768066010141 active site 768066010142 DNA binding site [nucleotide binding] 768066010143 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 768066010144 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768066010145 Catalytic site [active] 768066010146 Putative helicase; Region: TraI_2; pfam07514 768066010147 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 768066010148 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 768066010149 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 768066010150 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 768066010151 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 768066010152 active site 768066010153 catalytic residues [active] 768066010154 DNA binding site [nucleotide binding] 768066010155 Int/Topo IB signature motif; other site 768066010156 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 768066010157 L-lactate permease; Region: Lactate_perm; cl00701 768066010158 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 768066010159 L-lactate permease; Region: Lactate_perm; cl00701 768066010160 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768066010161 Uncharacterized conserved protein [Function unknown]; Region: COG0398 768066010162 mercuric reductase; Validated; Region: PRK06370 768066010163 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066010164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066010165 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768066010166 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 768066010167 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 768066010168 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 768066010169 Cytochrome P450; Region: p450; cl12078 768066010170 Protein of unknown function (DUF416); Region: DUF416; pfam04222 768066010171 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768066010172 active site 768066010173 DNA binding site [nucleotide binding] 768066010174 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 768066010175 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 768066010176 catalytic triad [active] 768066010177 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768066010178 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 768066010179 active site residue [active] 768066010180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066010181 Walker A/P-loop; other site 768066010182 ATP binding site [chemical binding]; other site 768066010183 Q-loop/lid; other site 768066010184 selenophosphate synthetase; Provisional; Region: PRK00943 768066010185 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 768066010186 dimerization interface [polypeptide binding]; other site 768066010187 putative ATP binding site [chemical binding]; other site 768066010188 DNA repair protein RadA; Provisional; Region: PRK11823 768066010189 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 768066010190 Walker A motif/ATP binding site; other site 768066010191 ATP binding site [chemical binding]; other site 768066010192 Walker B motif; other site 768066010193 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768066010194 NlpE N-terminal domain; Region: NlpE; pfam04170 768066010195 Predicted permeases [General function prediction only]; Region: COG0679 768066010196 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 768066010197 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066010198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066010199 homodimer interface [polypeptide binding]; other site 768066010200 catalytic residue [active] 768066010201 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 768066010202 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066010203 active site 768066010204 metal binding site [ion binding]; metal-binding site 768066010205 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 768066010206 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 768066010207 active site 768066010208 HIGH motif; other site 768066010209 dimer interface [polypeptide binding]; other site 768066010210 KMSKS motif; other site 768066010211 S4 domain; Region: S4_2; cl17325 768066010212 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 768066010213 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 768066010214 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768066010215 Walker A motif; other site 768066010216 ATP binding site [chemical binding]; other site 768066010217 Walker B motif; other site 768066010218 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 768066010219 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768066010220 catalytic residue [active] 768066010221 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 768066010222 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 768066010223 YGGT family; Region: YGGT; pfam02325 768066010224 YGGT family; Region: YGGT; pfam02325 768066010225 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 768066010226 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 768066010227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768066010228 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 768066010229 hypothetical protein; Provisional; Region: PRK08960 768066010230 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768066010231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066010232 homodimer interface [polypeptide binding]; other site 768066010233 catalytic residue [active] 768066010234 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 768066010235 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 768066010236 active site 768066010237 HIGH motif; other site 768066010238 nucleotide binding site [chemical binding]; other site 768066010239 KMSKS motif; other site 768066010240 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768066010241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066010242 dimer interface [polypeptide binding]; other site 768066010243 phosphorylation site [posttranslational modification] 768066010244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066010245 ATP binding site [chemical binding]; other site 768066010246 Mg2+ binding site [ion binding]; other site 768066010247 G-X-G motif; other site 768066010248 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768066010249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066010250 active site 768066010251 phosphorylation site [posttranslational modification] 768066010252 intermolecular recognition site; other site 768066010253 dimerization interface [polypeptide binding]; other site 768066010254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066010255 Walker A motif; other site 768066010256 ATP binding site [chemical binding]; other site 768066010257 Walker B motif; other site 768066010258 arginine finger; other site 768066010259 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 768066010260 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768066010261 active site 768066010262 NTP binding site [chemical binding]; other site 768066010263 metal binding triad [ion binding]; metal-binding site 768066010264 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768066010265 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 768066010266 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 768066010267 catalytic center binding site [active] 768066010268 ATP binding site [chemical binding]; other site 768066010269 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 768066010270 oligomerization interface [polypeptide binding]; other site 768066010271 active site 768066010272 metal binding site [ion binding]; metal-binding site 768066010273 Pantoate-beta-alanine ligase; Region: PanC; cd00560 768066010274 pantoate--beta-alanine ligase; Region: panC; TIGR00018 768066010275 active site 768066010276 ATP-binding site [chemical binding]; other site 768066010277 pantoate-binding site; other site 768066010278 HXXH motif; other site 768066010279 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 768066010280 tetramerization interface [polypeptide binding]; other site 768066010281 active site 768066010282 putative acyltransferase; Provisional; Region: PRK05790 768066010283 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768066010284 dimer interface [polypeptide binding]; other site 768066010285 active site 768066010286 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 768066010287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066010288 putative substrate translocation pore; other site 768066010289 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 768066010290 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 768066010291 RNase E interface [polypeptide binding]; other site 768066010292 trimer interface [polypeptide binding]; other site 768066010293 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 768066010294 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 768066010295 RNase E interface [polypeptide binding]; other site 768066010296 trimer interface [polypeptide binding]; other site 768066010297 active site 768066010298 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 768066010299 putative nucleic acid binding region [nucleotide binding]; other site 768066010300 G-X-X-G motif; other site 768066010301 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 768066010302 RNA binding site [nucleotide binding]; other site 768066010303 domain interface; other site 768066010304 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 768066010305 16S/18S rRNA binding site [nucleotide binding]; other site 768066010306 S13e-L30e interaction site [polypeptide binding]; other site 768066010307 25S rRNA binding site [nucleotide binding]; other site 768066010308 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 768066010309 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 768066010310 RNA binding site [nucleotide binding]; other site 768066010311 active site 768066010312 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 768066010313 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 768066010314 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768066010315 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 768066010316 translation initiation factor IF-2; Region: IF-2; TIGR00487 768066010317 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768066010318 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 768066010319 G1 box; other site 768066010320 putative GEF interaction site [polypeptide binding]; other site 768066010321 GTP/Mg2+ binding site [chemical binding]; other site 768066010322 Switch I region; other site 768066010323 G2 box; other site 768066010324 G3 box; other site 768066010325 Switch II region; other site 768066010326 G4 box; other site 768066010327 G5 box; other site 768066010328 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 768066010329 Translation-initiation factor 2; Region: IF-2; pfam11987 768066010330 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 768066010331 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 768066010332 NusA N-terminal domain; Region: NusA_N; pfam08529 768066010333 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 768066010334 RNA binding site [nucleotide binding]; other site 768066010335 homodimer interface [polypeptide binding]; other site 768066010336 NusA-like KH domain; Region: KH_5; pfam13184 768066010337 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768066010338 G-X-X-G motif; other site 768066010339 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 768066010340 ribosome maturation protein RimP; Reviewed; Region: PRK00092 768066010341 Sm and related proteins; Region: Sm_like; cl00259 768066010342 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 768066010343 putative oligomer interface [polypeptide binding]; other site 768066010344 putative RNA binding site [nucleotide binding]; other site 768066010345 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 768066010346 triosephosphate isomerase; Provisional; Region: PRK14567 768066010347 substrate binding site [chemical binding]; other site 768066010348 dimer interface [polypeptide binding]; other site 768066010349 catalytic triad [active] 768066010350 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 768066010351 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 768066010352 active site 768066010353 substrate binding site [chemical binding]; other site 768066010354 metal binding site [ion binding]; metal-binding site 768066010355 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 768066010356 dihydropteroate synthase; Region: DHPS; TIGR01496 768066010357 substrate binding pocket [chemical binding]; other site 768066010358 dimer interface [polypeptide binding]; other site 768066010359 inhibitor binding site; inhibition site 768066010360 FtsH Extracellular; Region: FtsH_ext; pfam06480 768066010361 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 768066010362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768066010363 Walker A motif; other site 768066010364 ATP binding site [chemical binding]; other site 768066010365 Walker B motif; other site 768066010366 arginine finger; other site 768066010367 Peptidase family M41; Region: Peptidase_M41; pfam01434 768066010368 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 768066010369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066010370 S-adenosylmethionine binding site [chemical binding]; other site 768066010371 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 768066010372 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 768066010373 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768066010374 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768066010375 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 768066010376 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768066010377 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768066010378 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 768066010379 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768066010380 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768066010381 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 768066010382 IMP binding site; other site 768066010383 dimer interface [polypeptide binding]; other site 768066010384 interdomain contacts; other site 768066010385 partial ornithine binding site; other site 768066010386 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 768066010387 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 768066010388 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 768066010389 catalytic site [active] 768066010390 subunit interface [polypeptide binding]; other site 768066010391 dihydrodipicolinate reductase; Provisional; Region: PRK00048 768066010392 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 768066010393 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 768066010394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 768066010395 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 768066010396 EamA-like transporter family; Region: EamA; pfam00892 768066010397 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 768066010398 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 768066010399 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 768066010400 putative ligand binding residues [chemical binding]; other site 768066010401 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768066010402 ABC-ATPase subunit interface; other site 768066010403 dimer interface [polypeptide binding]; other site 768066010404 putative PBP binding regions; other site 768066010405 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768066010406 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768066010407 Walker A/P-loop; other site 768066010408 ATP binding site [chemical binding]; other site 768066010409 Q-loop/lid; other site 768066010410 ABC transporter signature motif; other site 768066010411 Walker B; other site 768066010412 D-loop; other site 768066010413 H-loop/switch region; other site 768066010414 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768066010415 EamA-like transporter family; Region: EamA; pfam00892 768066010416 chaperone protein DnaJ; Provisional; Region: PRK10767 768066010417 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768066010418 HSP70 interaction site [polypeptide binding]; other site 768066010419 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 768066010420 Zn binding sites [ion binding]; other site 768066010421 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768066010422 dimer interface [polypeptide binding]; other site 768066010423 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 768066010424 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 768066010425 nucleotide binding site [chemical binding]; other site 768066010426 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 768066010427 GrpE; Region: GrpE; pfam01025 768066010428 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 768066010429 dimer interface [polypeptide binding]; other site 768066010430 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 768066010431 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 768066010432 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768066010433 Walker A/P-loop; other site 768066010434 ATP binding site [chemical binding]; other site 768066010435 Q-loop/lid; other site 768066010436 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768066010437 ABC transporter signature motif; other site 768066010438 Walker B; other site 768066010439 D-loop; other site 768066010440 H-loop/switch region; other site 768066010441 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768066010442 metal binding site 2 [ion binding]; metal-binding site 768066010443 putative DNA binding helix; other site 768066010444 metal binding site 1 [ion binding]; metal-binding site 768066010445 dimer interface [polypeptide binding]; other site 768066010446 structural Zn2+ binding site [ion binding]; other site 768066010447 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 768066010448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 768066010449 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 768066010450 putative coenzyme Q binding site [chemical binding]; other site 768066010451 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 768066010452 SmpB-tmRNA interface; other site 768066010453 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 768066010454 calmodulin; Provisional; Region: PTZ00184 768066010455 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 768066010456 Ca2+ binding site [ion binding]; other site 768066010457 SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate...; Region: SPARC_EC; cd00252 768066010458 collagen binding site [polypeptide binding]; other site 768066010459 EF-hand Ca2+ binding loops [ion binding]; other site 768066010460 FS-domain interface [polypeptide binding]; other site 768066010461 putative K+ binding site [ion binding]; other site 768066010462 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 768066010463 Ca2+ binding site [ion binding]; other site 768066010464 KilA-N domain; Region: KilA-N; pfam04383 768066010465 ORF11CD3 domain; Region: ORF11CD3; pfam10549 768066010466 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 768066010467 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 768066010468 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 768066010469 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 768066010470 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 768066010471 tandem repeat interface [polypeptide binding]; other site 768066010472 oligomer interface [polypeptide binding]; other site 768066010473 active site residues [active] 768066010474 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 768066010475 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 768066010476 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 768066010477 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 768066010478 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 768066010479 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 768066010480 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768066010481 active site 768066010482 metal binding site [ion binding]; metal-binding site 768066010483 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 768066010484 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 768066010485 active site 768066010486 metal binding site [ion binding]; metal-binding site 768066010487 interdomain interaction site; other site 768066010488 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 768066010489 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 768066010490 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 768066010491 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768066010492 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768066010493 cofactor binding site; other site 768066010494 DNA binding site [nucleotide binding] 768066010495 substrate interaction site [chemical binding]; other site 768066010496 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 768066010497 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768066010498 active site 768066010499 DNA binding site [nucleotide binding] 768066010500 Int/Topo IB signature motif; other site 768066010501 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768066010502 Ligand Binding Site [chemical binding]; other site 768066010503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066010504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066010505 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 768066010506 putative dimerization interface [polypeptide binding]; other site 768066010507 L-rhamnonate dehydratase; Provisional; Region: PRK15440 768066010508 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 768066010509 putative active site pocket [active] 768066010510 putative metal binding site [ion binding]; other site 768066010511 Domain of unknown function (DUF718); Region: DUF718; pfam05336 768066010512 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 768066010513 Amidohydrolase; Region: Amidohydro_2; pfam04909 768066010514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768066010515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066010516 NAD(P) binding site [chemical binding]; other site 768066010517 active site 768066010518 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 768066010519 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 768066010520 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768066010521 NAD binding site [chemical binding]; other site 768066010522 catalytic residues [active] 768066010523 substrate binding site [chemical binding]; other site 768066010524 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768066010525 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 768066010526 fructuronate transporter; Provisional; Region: PRK10034; cl15264 768066010527 fructuronate transporter; Provisional; Region: PRK10034; cl15264 768066010528 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768066010529 FAD binding domain; Region: FAD_binding_4; pfam01565 768066010530 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768066010531 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 768066010532 Helix-turn-helix domain; Region: HTH_18; pfam12833 768066010533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 768066010534 Protein of unknown function (DUF952); Region: DUF952; cl01393 768066010535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066010536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066010537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066010538 dimerization interface [polypeptide binding]; other site 768066010539 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066010540 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768066010541 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 768066010542 DctM-like transporters; Region: DctM; pfam06808 768066010543 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066010544 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 768066010545 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768066010546 DctM-like transporters; Region: DctM; pfam06808 768066010547 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 768066010548 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 768066010549 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768066010550 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768066010551 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 768066010552 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 768066010553 tetrameric interface [polypeptide binding]; other site 768066010554 NAD binding site [chemical binding]; other site 768066010555 catalytic residues [active] 768066010556 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 768066010557 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 768066010558 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768066010559 PYR/PP interface [polypeptide binding]; other site 768066010560 dimer interface [polypeptide binding]; other site 768066010561 TPP binding site [chemical binding]; other site 768066010562 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768066010563 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 768066010564 TPP-binding site; other site 768066010565 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768066010566 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 768066010567 substrate binding site [chemical binding]; other site 768066010568 ATP binding site [chemical binding]; other site 768066010569 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 768066010570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 768066010571 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 768066010572 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 768066010573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066010574 Walker A/P-loop; other site 768066010575 ATP binding site [chemical binding]; other site 768066010576 Q-loop/lid; other site 768066010577 ABC transporter signature motif; other site 768066010578 Walker B; other site 768066010579 D-loop; other site 768066010580 H-loop/switch region; other site 768066010581 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 768066010582 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768066010583 TM-ABC transporter signature motif; other site 768066010584 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 768066010585 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 768066010586 putative ligand binding site [chemical binding]; other site 768066010587 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 768066010588 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768066010589 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768066010590 putative active site [active] 768066010591 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768066010592 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768066010593 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768066010594 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 768066010595 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768066010596 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 768066010597 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768066010598 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768066010599 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 768066010600 pyruvate kinase; Provisional; Region: PRK05826 768066010601 domain interfaces; other site 768066010602 active site 768066010603 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 768066010604 active site 768066010605 dimer interfaces [polypeptide binding]; other site 768066010606 catalytic residues [active] 768066010607 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 768066010608 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768066010609 active site 768066010610 dimer interface [polypeptide binding]; other site 768066010611 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768066010612 dimer interface [polypeptide binding]; other site 768066010613 active site 768066010614 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 768066010615 CrcB-like protein; Region: CRCB; cl09114 768066010616 putative mechanosensitive channel protein; Provisional; Region: PRK11465 768066010617 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768066010618 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768066010619 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 768066010620 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768066010621 Walker A/P-loop; other site 768066010622 ATP binding site [chemical binding]; other site 768066010623 Q-loop/lid; other site 768066010624 ABC transporter signature motif; other site 768066010625 Walker B; other site 768066010626 D-loop; other site 768066010627 H-loop/switch region; other site 768066010628 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768066010629 FtsX-like permease family; Region: FtsX; pfam02687 768066010630 macrolide transporter subunit MacA; Provisional; Region: PRK11578 768066010631 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768066010632 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066010633 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 768066010634 HemY protein N-terminus; Region: HemY_N; pfam07219 768066010635 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 768066010636 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 768066010637 active site 768066010638 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 768066010639 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 768066010640 domain interfaces; other site 768066010641 active site 768066010642 argininosuccinate lyase; Provisional; Region: PRK00855 768066010643 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 768066010644 active sites [active] 768066010645 tetramer interface [polypeptide binding]; other site 768066010646 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 768066010647 diaminopimelate decarboxylase; Region: lysA; TIGR01048 768066010648 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 768066010649 active site 768066010650 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768066010651 substrate binding site [chemical binding]; other site 768066010652 catalytic residues [active] 768066010653 dimer interface [polypeptide binding]; other site 768066010654 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 768066010655 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768066010656 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768066010657 Protein of unknown function, DUF484; Region: DUF484; cl17449 768066010658 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768066010659 active site 768066010660 DNA binding site [nucleotide binding] 768066010661 Int/Topo IB signature motif; other site 768066010662 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 768066010663 G1 box; other site 768066010664 GTP/Mg2+ binding site [chemical binding]; other site 768066010665 Switch I region; other site 768066010666 G2 box; other site 768066010667 G3 box; other site 768066010668 Switch II region; other site 768066010669 G4 box; other site 768066010670 G5 box; other site 768066010671 Cytochrome c553 [Energy production and conversion]; Region: COG2863 768066010672 Cytochrome c; Region: Cytochrom_C; cl11414 768066010673 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 768066010674 catalytic residues [active] 768066010675 hinge region; other site 768066010676 alpha helical domain; other site 768066010677 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 768066010678 putative catalytic site [active] 768066010679 putative metal binding site [ion binding]; other site 768066010680 putative catalytic site [active] 768066010681 putative phosphate binding site [ion binding]; other site 768066010682 putative phosphate binding site [ion binding]; other site 768066010683 putative metal binding site [ion binding]; other site 768066010684 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 768066010685 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 768066010686 DctM-like transporters; Region: DctM; pfam06808 768066010687 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 768066010688 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066010689 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768066010690 substrate binding site [chemical binding]; other site 768066010691 dimer interface [polypeptide binding]; other site 768066010692 ATP binding site [chemical binding]; other site 768066010693 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768066010694 Ligand Binding Site [chemical binding]; other site 768066010695 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768066010696 Ligand Binding Site [chemical binding]; other site 768066010697 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 768066010698 putative active site [active] 768066010699 dimerization interface [polypeptide binding]; other site 768066010700 putative tRNAtyr binding site [nucleotide binding]; other site 768066010701 xanthine permease; Region: pbuX; TIGR03173 768066010702 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 768066010703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768066010704 Walker A/P-loop; other site 768066010705 ATP binding site [chemical binding]; other site 768066010706 Q-loop/lid; other site 768066010707 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768066010708 ABC transporter; Region: ABC_tran_2; pfam12848 768066010709 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768066010710 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768066010711 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066010712 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768066010713 DctM-like transporters; Region: DctM; pfam06808 768066010714 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 768066010715 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768066010716 Ligand Binding Site [chemical binding]; other site 768066010717 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 768066010718 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 768066010719 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768066010720 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 768066010721 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768066010722 Cu(I) binding site [ion binding]; other site 768066010723 Membrane transport protein; Region: Mem_trans; cl09117 768066010724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066010725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066010726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066010727 dimerization interface [polypeptide binding]; other site 768066010728 EamA-like transporter family; Region: EamA; pfam00892 768066010729 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768066010730 EamA-like transporter family; Region: EamA; pfam00892 768066010731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066010732 S-adenosylmethionine binding site [chemical binding]; other site 768066010733 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 768066010734 ThiS interaction site; other site 768066010735 putative active site [active] 768066010736 tetramer interface [polypeptide binding]; other site 768066010737 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 768066010738 thiS-thiF/thiG interaction site; other site 768066010739 Protein of unknown function (DUF423); Region: DUF423; pfam04241 768066010740 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 768066010741 CoenzymeA binding site [chemical binding]; other site 768066010742 subunit interaction site [polypeptide binding]; other site 768066010743 PHB binding site; other site 768066010744 malate synthase G; Provisional; Region: PRK02999 768066010745 active site 768066010746 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 768066010747 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 768066010748 WYL domain; Region: WYL; pfam13280 768066010749 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 768066010750 BCCT family transporter; Region: BCCT; cl00569 768066010751 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768066010752 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 768066010753 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768066010754 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768066010755 dimer interface [polypeptide binding]; other site 768066010756 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768066010757 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768066010758 intersubunit interface [polypeptide binding]; other site 768066010759 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 768066010760 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768066010761 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768066010762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066010763 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 768066010764 putative effector binding pocket; other site 768066010765 dimerization interface [polypeptide binding]; other site 768066010766 Predicted membrane protein [Function unknown]; Region: COG2259 768066010767 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 768066010768 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 768066010769 putative active site [active] 768066010770 metal binding site [ion binding]; metal-binding site 768066010771 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768066010772 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 768066010773 dimer interface [polypeptide binding]; other site 768066010774 active site 768066010775 metal binding site [ion binding]; metal-binding site 768066010776 glutathione binding site [chemical binding]; other site 768066010777 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768066010778 NlpC/P60 family; Region: NLPC_P60; pfam00877 768066010779 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 768066010780 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 768066010781 dimer interface [polypeptide binding]; other site 768066010782 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768066010783 catalytic triad [active] 768066010784 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 768066010785 substrate binding site [chemical binding]; other site 768066010786 multimerization interface [polypeptide binding]; other site 768066010787 ATP binding site [chemical binding]; other site 768066010788 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768066010789 thiamine phosphate binding site [chemical binding]; other site 768066010790 active site 768066010791 pyrophosphate binding site [ion binding]; other site 768066010792 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768066010793 EamA-like transporter family; Region: EamA; pfam00892 768066010794 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 768066010795 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 768066010796 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768066010797 Proline racemase; Region: Pro_racemase; pfam05544 768066010798 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 768066010799 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 768066010800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 768066010801 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066010802 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 768066010803 inhibitor-cofactor binding pocket; inhibition site 768066010804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066010805 catalytic residue [active] 768066010806 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066010807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066010808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066010809 dimerization interface [polypeptide binding]; other site 768066010810 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 768066010811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066010812 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 768066010813 dimerization interface [polypeptide binding]; other site 768066010814 substrate binding pocket [chemical binding]; other site 768066010815 aldehyde dehydrogenase family 7 member; Region: PLN02315 768066010816 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 768066010817 tetrameric interface [polypeptide binding]; other site 768066010818 NAD binding site [chemical binding]; other site 768066010819 catalytic residues [active] 768066010820 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 768066010821 putative substrate binding site 2 [chemical binding]; other site 768066010822 putative substrate binding site 1 [chemical binding]; other site 768066010823 Na binding site 1 [ion binding]; other site 768066010824 Na2 binding site [ion binding]; other site 768066010825 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 768066010826 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 768066010827 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768066010828 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768066010829 Walker A/P-loop; other site 768066010830 ATP binding site [chemical binding]; other site 768066010831 Q-loop/lid; other site 768066010832 ABC transporter signature motif; other site 768066010833 Walker B; other site 768066010834 D-loop; other site 768066010835 H-loop/switch region; other site 768066010836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066010837 dimer interface [polypeptide binding]; other site 768066010838 conserved gate region; other site 768066010839 putative PBP binding loops; other site 768066010840 ABC-ATPase subunit interface; other site 768066010841 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 768066010842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066010843 conserved gate region; other site 768066010844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066010845 dimer interface [polypeptide binding]; other site 768066010846 ABC-ATPase subunit interface; other site 768066010847 putative PBP binding loops; other site 768066010848 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 768066010849 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768066010850 substrate binding pocket [chemical binding]; other site 768066010851 membrane-bound complex binding site; other site 768066010852 hinge residues; other site 768066010853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768066010854 dimerization interface [polypeptide binding]; other site 768066010855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768066010856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066010857 dimer interface [polypeptide binding]; other site 768066010858 phosphorylation site [posttranslational modification] 768066010859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066010860 ATP binding site [chemical binding]; other site 768066010861 Mg2+ binding site [ion binding]; other site 768066010862 G-X-G motif; other site 768066010863 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768066010864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066010865 active site 768066010866 phosphorylation site [posttranslational modification] 768066010867 intermolecular recognition site; other site 768066010868 dimerization interface [polypeptide binding]; other site 768066010869 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066010870 DNA binding site [nucleotide binding] 768066010871 Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292 768066010872 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 768066010873 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 768066010874 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 768066010875 Moco binding site; other site 768066010876 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 768066010877 metal coordination site [ion binding]; other site 768066010878 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 768066010879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066010880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768066010881 dimerization interface [polypeptide binding]; other site 768066010882 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 768066010883 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 768066010884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066010885 catalytic residue [active] 768066010886 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 768066010887 substrate binding site [chemical binding]; other site 768066010888 active site 768066010889 catalytic residues [active] 768066010890 heterodimer interface [polypeptide binding]; other site 768066010891 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 768066010892 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 768066010893 catalytic residue [active] 768066010894 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 768066010895 catalytic residues [active] 768066010896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768066010897 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066010898 peroxiredoxin; Region: AhpC; TIGR03137 768066010899 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 768066010900 dimer interface [polypeptide binding]; other site 768066010901 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768066010902 catalytic triad [active] 768066010903 peroxidatic and resolving cysteines [active] 768066010904 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 768066010905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768066010906 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768066010907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768066010908 DNA binding residues [nucleotide binding] 768066010909 Flagellar protein FlhE; Region: FlhE; pfam06366 768066010910 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 768066010911 FHIPEP family; Region: FHIPEP; pfam00771 768066010912 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 768066010913 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 768066010914 chemotaxis regulator CheZ; Provisional; Region: PRK11166 768066010915 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 768066010916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066010917 active site 768066010918 phosphorylation site [posttranslational modification] 768066010919 intermolecular recognition site; other site 768066010920 dimerization interface [polypeptide binding]; other site 768066010921 CheB methylesterase; Region: CheB_methylest; pfam01339 768066010922 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 768066010923 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 768066010924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768066010925 S-adenosylmethionine binding site [chemical binding]; other site 768066010926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768066010927 PAS fold; Region: PAS_3; pfam08447 768066010928 putative active site [active] 768066010929 heme pocket [chemical binding]; other site 768066010930 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768066010931 dimer interface [polypeptide binding]; other site 768066010932 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 768066010933 putative CheW interface [polypeptide binding]; other site 768066010934 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 768066010935 dimer interface [polypeptide binding]; other site 768066010936 ligand binding site [chemical binding]; other site 768066010937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768066010938 dimerization interface [polypeptide binding]; other site 768066010939 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768066010940 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768066010941 dimer interface [polypeptide binding]; other site 768066010942 putative CheW interface [polypeptide binding]; other site 768066010943 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 768066010944 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768066010945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768066010946 dimer interface [polypeptide binding]; other site 768066010947 putative CheW interface [polypeptide binding]; other site 768066010948 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 768066010949 putative CheA interaction surface; other site 768066010950 chemotaxis protein CheA; Provisional; Region: PRK10547 768066010951 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768066010952 putative binding surface; other site 768066010953 active site 768066010954 CheY binding; Region: CheY-binding; pfam09078 768066010955 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 768066010956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066010957 ATP binding site [chemical binding]; other site 768066010958 Mg2+ binding site [ion binding]; other site 768066010959 G-X-G motif; other site 768066010960 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 768066010961 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 768066010962 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 768066010963 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768066010964 ligand binding site [chemical binding]; other site 768066010965 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 768066010966 flagellar motor protein MotA; Validated; Region: PRK09110 768066010967 transcriptional activator FlhC; Provisional; Region: PRK12722 768066010968 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 768066010969 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 768066010970 Flagellar protein FliT; Region: FliT; cl05125 768066010971 Flagellar protein FliS; Region: FliS; cl00654 768066010972 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 768066010973 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768066010974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768066010975 binding surface 768066010976 TPR motif; other site 768066010977 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 768066010978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768066010979 TPR motif; other site 768066010980 binding surface 768066010981 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768066010982 flagellin; Reviewed; Region: PRK08869 768066010983 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768066010984 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768066010985 flagellin; Provisional; Region: PRK12802 768066010986 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768066010987 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768066010988 flagellar capping protein; Reviewed; Region: fliD; PRK08032 768066010989 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 768066010990 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 768066010991 flagellar capping protein; Reviewed; Region: fliD; PRK08032 768066010992 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 768066010993 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 768066010994 Cache domain; Region: Cache_1; pfam02743 768066010995 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768066010996 dimerization interface [polypeptide binding]; other site 768066010997 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768066010998 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768066010999 dimer interface [polypeptide binding]; other site 768066011000 putative CheW interface [polypeptide binding]; other site 768066011001 FlaG protein; Region: FlaG; pfam03646 768066011002 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 768066011003 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 768066011004 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 768066011005 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 768066011006 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 768066011007 FliG C-terminal domain; Region: FliG_C; pfam01706 768066011008 flagellar assembly protein H; Validated; Region: fliH; PRK05687 768066011009 Flagellar assembly protein FliH; Region: FliH; pfam02108 768066011010 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 768066011011 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 768066011012 Walker A motif/ATP binding site; other site 768066011013 Walker B motif; other site 768066011014 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 768066011015 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 768066011016 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 768066011017 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 768066011018 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 768066011019 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 768066011020 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 768066011021 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 768066011022 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 768066011023 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 768066011024 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 768066011025 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768066011026 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768066011027 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 768066011028 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768066011029 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768066011030 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 768066011031 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 768066011032 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 768066011033 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 768066011034 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 768066011035 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 768066011036 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 768066011037 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 768066011038 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768066011039 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768066011040 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 768066011041 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768066011042 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768066011043 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 768066011044 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 768066011045 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768066011046 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 768066011047 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 768066011048 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 768066011049 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 768066011050 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768066011051 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768066011052 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 768066011053 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 768066011054 SAF-like; Region: SAF_2; pfam13144 768066011055 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 768066011056 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 768066011057 FlgN protein; Region: FlgN; pfam05130 768066011058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768066011059 metal binding site [ion binding]; metal-binding site 768066011060 active site 768066011061 I-site; other site 768066011062 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768066011063 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 768066011064 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 768066011065 potential catalytic triad [active] 768066011066 conserved cys residue [active] 768066011067 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 768066011068 substrate binding site [chemical binding]; other site 768066011069 THF binding site; other site 768066011070 zinc-binding site [ion binding]; other site 768066011071 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 768066011072 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 768066011073 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 768066011074 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 768066011075 Part of AAA domain; Region: AAA_19; pfam13245 768066011076 Family description; Region: UvrD_C_2; pfam13538 768066011077 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 768066011078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768066011079 active site 768066011080 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 768066011081 putative active site [active] 768066011082 putative catalytic site [active] 768066011083 putative DNA binding site [nucleotide binding]; other site 768066011084 putative phosphate binding site [ion binding]; other site 768066011085 metal binding site A [ion binding]; metal-binding site 768066011086 putative AP binding site [nucleotide binding]; other site 768066011087 putative metal binding site B [ion binding]; other site 768066011088 ribonuclease PH; Reviewed; Region: rph; PRK00173 768066011089 Ribonuclease PH; Region: RNase_PH_bact; cd11362 768066011090 hexamer interface [polypeptide binding]; other site 768066011091 active site 768066011092 hypothetical protein; Provisional; Region: PRK11820 768066011093 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 768066011094 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 768066011095 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 768066011096 Sodium Bile acid symporter family; Region: SBF; cl17470 768066011097 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768066011098 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768066011099 DNA binding site [nucleotide binding] 768066011100 substrate interaction site [chemical binding]; other site 768066011101 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 768066011102 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 768066011103 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 768066011104 Z1 domain; Region: Z1; pfam10593 768066011105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066011106 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768066011107 putative substrate translocation pore; other site 768066011108 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 768066011109 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 768066011110 catalytic site [active] 768066011111 G-X2-G-X-G-K; other site 768066011112 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 768066011113 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768066011114 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768066011115 Zn2+ binding site [ion binding]; other site 768066011116 Mg2+ binding site [ion binding]; other site 768066011117 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768066011118 synthetase active site [active] 768066011119 NTP binding site [chemical binding]; other site 768066011120 metal binding site [ion binding]; metal-binding site 768066011121 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768066011122 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768066011123 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768066011124 homotrimer interaction site [polypeptide binding]; other site 768066011125 putative active site [active] 768066011126 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 768066011127 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768066011128 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768066011129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768066011130 NAD(P) binding site [chemical binding]; other site 768066011131 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768066011132 active site 768066011133 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 768066011134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768066011135 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 768066011136 dimerization interface [polypeptide binding]; other site 768066011137 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 768066011138 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 768066011139 ssDNA binding site; other site 768066011140 generic binding surface II; other site 768066011141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768066011142 ATP binding site [chemical binding]; other site 768066011143 putative Mg++ binding site [ion binding]; other site 768066011144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768066011145 nucleotide binding region [chemical binding]; other site 768066011146 ATP-binding site [chemical binding]; other site 768066011147 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 768066011148 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 768066011149 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 768066011150 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768066011151 IHF dimer interface [polypeptide binding]; other site 768066011152 IHF - DNA interface [nucleotide binding]; other site 768066011153 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 768066011154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768066011155 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 768066011156 UbiA prenyltransferase family; Region: UbiA; pfam01040 768066011157 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 768066011158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768066011159 active site 768066011160 phosphorylation site [posttranslational modification] 768066011161 intermolecular recognition site; other site 768066011162 dimerization interface [polypeptide binding]; other site 768066011163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768066011164 DNA binding site [nucleotide binding] 768066011165 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 768066011166 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 768066011167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768066011168 putative active site [active] 768066011169 heme pocket [chemical binding]; other site 768066011170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768066011171 dimer interface [polypeptide binding]; other site 768066011172 phosphorylation site [posttranslational modification] 768066011173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768066011174 ATP binding site [chemical binding]; other site 768066011175 Mg2+ binding site [ion binding]; other site 768066011176 G-X-G motif; other site 768066011177 putative sulfate transport protein CysZ; Validated; Region: PRK04949 768066011178 transcriptional regulator PhoU; Provisional; Region: PRK11115 768066011179 PhoU domain; Region: PhoU; pfam01895 768066011180 PhoU domain; Region: PhoU; pfam01895 768066011181 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 768066011182 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768066011183 Walker A/P-loop; other site 768066011184 ATP binding site [chemical binding]; other site 768066011185 Q-loop/lid; other site 768066011186 ABC transporter signature motif; other site 768066011187 Walker B; other site 768066011188 D-loop; other site 768066011189 H-loop/switch region; other site 768066011190 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 768066011191 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 768066011192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066011193 dimer interface [polypeptide binding]; other site 768066011194 conserved gate region; other site 768066011195 putative PBP binding loops; other site 768066011196 ABC-ATPase subunit interface; other site 768066011197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066011198 ABC-ATPase subunit interface; other site 768066011199 PBP superfamily domain; Region: PBP_like_2; cl17296 768066011200 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768066011201 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 768066011202 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768066011203 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 768066011204 Part of AAA domain; Region: AAA_19; pfam13245 768066011205 Family description; Region: UvrD_C_2; pfam13538 768066011206 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 768066011207 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 768066011208 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 768066011209 putative active site [active] 768066011210 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 768066011211 Na2 binding site [ion binding]; other site 768066011212 putative substrate binding site 1 [chemical binding]; other site 768066011213 Na binding site 1 [ion binding]; other site 768066011214 putative substrate binding site 2 [chemical binding]; other site 768066011215 Protein of unknown function DUF72; Region: DUF72; cl00777 768066011216 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 768066011217 catalytic residues [active] 768066011218 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 768066011219 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 768066011220 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 768066011221 Class I ribonucleotide reductase; Region: RNR_I; cd01679 768066011222 active site 768066011223 dimer interface [polypeptide binding]; other site 768066011224 catalytic residues [active] 768066011225 effector binding site; other site 768066011226 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 768066011227 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 768066011228 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 768066011229 dimer interface [polypeptide binding]; other site 768066011230 putative radical transfer pathway; other site 768066011231 diiron center [ion binding]; other site 768066011232 tyrosyl radical; other site 768066011233 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 768066011234 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 768066011235 glutaminase active site [active] 768066011236 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768066011237 dimer interface [polypeptide binding]; other site 768066011238 active site 768066011239 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768066011240 dimer interface [polypeptide binding]; other site 768066011241 active site 768066011242 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 768066011243 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 768066011244 Substrate binding site; other site 768066011245 Mg++ binding site; other site 768066011246 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 768066011247 active site 768066011248 substrate binding site [chemical binding]; other site 768066011249 CoA binding site [chemical binding]; other site 768066011250 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 768066011251 ApbE family; Region: ApbE; pfam02424 768066011252 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 768066011253 MgtE intracellular N domain; Region: MgtE_N; pfam03448 768066011254 FOG: CBS domain [General function prediction only]; Region: COG0517 768066011255 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 768066011256 Divalent cation transporter; Region: MgtE; pfam01769 768066011257 Transcriptional regulators [Transcription]; Region: MarR; COG1846 768066011258 MarR family; Region: MarR_2; pfam12802 768066011259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768066011260 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 768066011261 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768066011262 HlyD family secretion protein; Region: HlyD_3; pfam13437 768066011263 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 768066011264 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 768066011265 gamma subunit interface [polypeptide binding]; other site 768066011266 epsilon subunit interface [polypeptide binding]; other site 768066011267 LBP interface [polypeptide binding]; other site 768066011268 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 768066011269 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768066011270 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 768066011271 alpha subunit interaction interface [polypeptide binding]; other site 768066011272 Walker A motif; other site 768066011273 ATP binding site [chemical binding]; other site 768066011274 Walker B motif; other site 768066011275 inhibitor binding site; inhibition site 768066011276 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768066011277 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 768066011278 core domain interface [polypeptide binding]; other site 768066011279 delta subunit interface [polypeptide binding]; other site 768066011280 epsilon subunit interface [polypeptide binding]; other site 768066011281 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 768066011282 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768066011283 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 768066011284 beta subunit interaction interface [polypeptide binding]; other site 768066011285 Walker A motif; other site 768066011286 ATP binding site [chemical binding]; other site 768066011287 Walker B motif; other site 768066011288 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768066011289 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 768066011290 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 768066011291 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 768066011292 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 768066011293 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 768066011294 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 768066011295 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 768066011296 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 768066011297 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 768066011298 ParB-like nuclease domain; Region: ParBc; pfam02195 768066011299 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768066011300 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768066011301 P-loop; other site 768066011302 Magnesium ion binding site [ion binding]; other site 768066011303 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 768066011304 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 768066011305 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 768066011306 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 768066011307 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 768066011308 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 768066011309 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768066011310 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768066011311 Walker A/P-loop; other site 768066011312 ATP binding site [chemical binding]; other site 768066011313 Q-loop/lid; other site 768066011314 ABC transporter signature motif; other site 768066011315 Walker B; other site 768066011316 D-loop; other site 768066011317 H-loop/switch region; other site 768066011318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768066011319 dimer interface [polypeptide binding]; other site 768066011320 conserved gate region; other site 768066011321 putative PBP binding loops; other site 768066011322 ABC-ATPase subunit interface; other site 768066011323 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768066011324 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768066011325 substrate binding pocket [chemical binding]; other site 768066011326 membrane-bound complex binding site; other site 768066011327 hinge residues; other site 768066011328 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 768066011329 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 768066011330 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768066011331 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768066011332 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768066011333 Cl- selectivity filter; other site 768066011334 Cl- binding residues [ion binding]; other site 768066011335 pore gating glutamate residue; other site 768066011336 dimer interface [polypeptide binding]; other site 768066011337 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 768066011338 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768066011339 dimer interface [polypeptide binding]; other site 768066011340 substrate binding site [chemical binding]; other site 768066011341 ATP binding site [chemical binding]; other site 768066011342 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 768066011343 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768066011344 inhibitor-cofactor binding pocket; inhibition site 768066011345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768066011346 catalytic residue [active] 768066011347 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 768066011348 AAA domain; Region: AAA_33; pfam13671 768066011349 active site 768066011350 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 768066011351 active site 768066011352 dimerization interface [polypeptide binding]; other site 768066011353 HemN family oxidoreductase; Provisional; Region: PRK05660 768066011354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 768066011355 FeS/SAM binding site; other site 768066011356 HemN C-terminal domain; Region: HemN_C; pfam06969 768066011357 putative outer membrane lipoprotein; Provisional; Region: PRK10510 768066011358 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768066011359 ligand binding site [chemical binding]; other site 768066011360 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 768066011361 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 768066011362 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 768066011363 trmE is a tRNA modification GTPase; Region: trmE; cd04164 768066011364 G1 box; other site 768066011365 GTP/Mg2+ binding site [chemical binding]; other site 768066011366 Switch I region; other site 768066011367 G2 box; other site 768066011368 Switch II region; other site 768066011369 G3 box; other site 768066011370 G4 box; other site 768066011371 G5 box; other site 768066011372 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 768066011373 membrane protein insertase; Provisional; Region: PRK01318 768066011374 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 768066011375 Ribonuclease P; Region: Ribonuclease_P; cl00457 768066011376 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399