-- dump date   	20140619_111559
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
349124000001	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
349124000002	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
349124000003	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
349124000004	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
349124000005	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
349124000006	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
349124000007	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08722
349124000008	dimer interface [polypeptide binding]; other site
349124000009	active site
349124000010	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
349124000011	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
349124000012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124000013	catalytic residue [active]
349124000014	YceG-like family; Region: YceG; pfam02618
349124000015	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
349124000016	dimerization interface [polypeptide binding]; other site
349124000017	thymidylate kinase; Validated; Region: tmk; PRK00698
349124000018	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
349124000019	TMP-binding site; other site
349124000020	ATP-binding site [chemical binding]; other site
349124000021	DNA polymerase III subunit delta'; Validated; Region: PRK06871
349124000022	DNA polymerase III subunit delta'; Validated; Region: PRK08485
349124000023	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
349124000024	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349124000025	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349124000026	catalytic residue [active]
349124000027	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349124000028	NAD(P) binding site [chemical binding]; other site
349124000029	active site
349124000030	glycerate dehydrogenase; Provisional; Region: PRK06487
349124000031	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
349124000032	putative ligand binding site [chemical binding]; other site
349124000033	putative NAD binding site [chemical binding]; other site
349124000034	catalytic site [active]
349124000035	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
349124000036	Walker A motif; other site
349124000037	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
349124000038	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
349124000039	acyl-activating enzyme (AAE) consensus motif; other site
349124000040	putative AMP binding site [chemical binding]; other site
349124000041	putative active site [active]
349124000042	putative CoA binding site [chemical binding]; other site
349124000043	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
349124000044	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
349124000045	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
349124000046	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
349124000047	G1 box; other site
349124000048	putative GEF interaction site [polypeptide binding]; other site
349124000049	GTP/Mg2+ binding site [chemical binding]; other site
349124000050	Switch I region; other site
349124000051	G2 box; other site
349124000052	G3 box; other site
349124000053	Switch II region; other site
349124000054	G4 box; other site
349124000055	G5 box; other site
349124000056	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
349124000057	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
349124000058	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
349124000059	active site 1 [active]
349124000060	dimer interface [polypeptide binding]; other site
349124000061	active site 2 [active]
349124000062	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
349124000063	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
349124000064	dimer interface [polypeptide binding]; other site
349124000065	active site
349124000066	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
349124000067	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124000068	FeS/SAM binding site; other site
349124000069	HemN C-terminal domain; Region: HemN_C; pfam06969
349124000070	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
349124000071	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
349124000072	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
349124000073	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
349124000074	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
349124000075	GIY-YIG motif/motif A; other site
349124000076	active site
349124000077	catalytic site [active]
349124000078	putative DNA binding site [nucleotide binding]; other site
349124000079	metal binding site [ion binding]; metal-binding site
349124000080	UvrB/uvrC motif; Region: UVR; pfam02151
349124000081	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
349124000082	response regulator; Provisional; Region: PRK09483
349124000083	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124000084	active site
349124000085	phosphorylation site [posttranslational modification]
349124000086	intermolecular recognition site; other site
349124000087	dimerization interface [polypeptide binding]; other site
349124000088	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349124000089	DNA binding residues [nucleotide binding]
349124000090	dimerization interface [polypeptide binding]; other site
349124000091	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
349124000092	LabA_like proteins; Region: LabA_like; cd06167
349124000093	putative metal binding site [ion binding]; other site
349124000094	fumarate hydratase; Reviewed; Region: fumC; PRK00485
349124000095	Class II fumarases; Region: Fumarase_classII; cd01362
349124000096	active site
349124000097	tetramer interface [polypeptide binding]; other site
349124000098	adenylosuccinate lyase; Provisional; Region: PRK09285
349124000099	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
349124000100	tetramer interface [polypeptide binding]; other site
349124000101	active site
349124000102	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
349124000103	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
349124000104	dimer interface [polypeptide binding]; other site
349124000105	ADP-ribose binding site [chemical binding]; other site
349124000106	active site
349124000107	nudix motif; other site
349124000108	metal binding site [ion binding]; metal-binding site
349124000109	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
349124000110	TRAM domain; Region: TRAM; pfam01938
349124000111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124000112	S-adenosylmethionine binding site [chemical binding]; other site
349124000113	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
349124000114	active site
349124000115	catalytic site [active]
349124000116	substrate binding site [chemical binding]; other site
349124000117	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
349124000118	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
349124000119	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
349124000120	active site
349124000121	hydrophilic channel; other site
349124000122	dimerization interface [polypeptide binding]; other site
349124000123	catalytic residues [active]
349124000124	active site lid [active]
349124000125	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
349124000126	Recombination protein O N terminal; Region: RecO_N; pfam11967
349124000127	Recombination protein O C terminal; Region: RecO_C; pfam02565
349124000128	GTPase Era; Reviewed; Region: era; PRK00089
349124000129	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
349124000130	G1 box; other site
349124000131	GTP/Mg2+ binding site [chemical binding]; other site
349124000132	Switch I region; other site
349124000133	G2 box; other site
349124000134	Switch II region; other site
349124000135	G3 box; other site
349124000136	G4 box; other site
349124000137	G5 box; other site
349124000138	KH domain; Region: KH_2; pfam07650
349124000139	ribonuclease III; Reviewed; Region: rnc; PRK00102
349124000140	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
349124000141	dimerization interface [polypeptide binding]; other site
349124000142	active site
349124000143	metal binding site [ion binding]; metal-binding site
349124000144	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
349124000145	dsRNA binding site [nucleotide binding]; other site
349124000146	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
349124000147	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
349124000148	Catalytic site [active]
349124000149	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
349124000150	GTP-binding protein LepA; Provisional; Region: PRK05433
349124000151	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
349124000152	G1 box; other site
349124000153	putative GEF interaction site [polypeptide binding]; other site
349124000154	GTP/Mg2+ binding site [chemical binding]; other site
349124000155	Switch I region; other site
349124000156	G2 box; other site
349124000157	G3 box; other site
349124000158	Switch II region; other site
349124000159	G4 box; other site
349124000160	G5 box; other site
349124000161	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
349124000162	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
349124000163	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
349124000164	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
349124000165	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349124000166	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349124000167	protein binding site [polypeptide binding]; other site
349124000168	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349124000169	protein binding site [polypeptide binding]; other site
349124000170	anti-sigma E factor; Provisional; Region: rseB; PRK09455
349124000171	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
349124000172	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
349124000173	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
349124000174	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349124000175	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349124000176	DNA binding residues [nucleotide binding]
349124000177	L-aspartate oxidase; Provisional; Region: PRK09077
349124000178	L-aspartate oxidase; Provisional; Region: PRK06175
349124000179	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
349124000180	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
349124000181	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
349124000182	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349124000183	catalytic loop [active]
349124000184	iron binding site [ion binding]; other site
349124000185	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
349124000186	L-aspartate oxidase; Provisional; Region: PRK06175
349124000187	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
349124000188	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
349124000189	putative SdhC subunit interface [polypeptide binding]; other site
349124000190	putative proximal heme binding site [chemical binding]; other site
349124000191	putative Iron-sulfur protein interface [polypeptide binding]; other site
349124000192	putative proximal quinone binding site; other site
349124000193	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
349124000194	Iron-sulfur protein interface; other site
349124000195	proximal quinone binding site [chemical binding]; other site
349124000196	SdhD (CybS) interface [polypeptide binding]; other site
349124000197	proximal heme binding site [chemical binding]; other site
349124000198	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
349124000199	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
349124000200	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
349124000201	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
349124000202	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
349124000203	dimer interface [polypeptide binding]; other site
349124000204	putative anticodon binding site; other site
349124000205	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
349124000206	motif 1; other site
349124000207	active site
349124000208	motif 2; other site
349124000209	motif 3; other site
349124000210	peptide chain release factor 2; Provisional; Region: PRK08787
349124000211	This domain is found in peptide chain release factors; Region: PCRF; smart00937
349124000212	RF-1 domain; Region: RF-1; pfam00472
349124000213	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
349124000214	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
349124000215	homotetramer interface [polypeptide binding]; other site
349124000216	ligand binding site [chemical binding]; other site
349124000217	catalytic site [active]
349124000218	NAD binding site [chemical binding]; other site
349124000219	Protein of unknown function (DUF2452); Region: DUF2452; pfam10504
349124000220	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
349124000221	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
349124000222	acyl-activating enzyme (AAE) consensus motif; other site
349124000223	putative AMP binding site [chemical binding]; other site
349124000224	putative active site [active]
349124000225	putative CoA binding site [chemical binding]; other site
349124000226	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
349124000227	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349124000228	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
349124000229	putative acyl-acceptor binding pocket; other site
349124000230	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
349124000231	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
349124000232	FAD binding domain; Region: FAD_binding_4; pfam01565
349124000233	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
349124000234	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
349124000235	Cysteine-rich domain; Region: CCG; pfam02754
349124000236	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
349124000237	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
349124000238	NnrU protein; Region: NnrU; pfam07298
349124000239	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
349124000240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124000241	S-adenosylmethionine binding site [chemical binding]; other site
349124000242	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
349124000243	PAS fold; Region: PAS_4; pfam08448
349124000244	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124000245	putative active site [active]
349124000246	heme pocket [chemical binding]; other site
349124000247	PAS domain S-box; Region: sensory_box; TIGR00229
349124000248	PAS domain; Region: PAS; smart00091
349124000249	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124000250	PAS domain; Region: PAS_9; pfam13426
349124000251	putative active site [active]
349124000252	heme pocket [chemical binding]; other site
349124000253	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124000254	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124000255	metal binding site [ion binding]; metal-binding site
349124000256	active site
349124000257	I-site; other site
349124000258	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124000259	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124000260	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
349124000261	glutamate dehydrogenase; Provisional; Region: PRK09414
349124000262	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
349124000263	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
349124000264	NAD(P) binding site [chemical binding]; other site
349124000265	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
349124000266	electron transport complex RsxE subunit; Provisional; Region: PRK12405
349124000267	FMN-binding domain; Region: FMN_bind; cl01081
349124000268	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
349124000269	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
349124000270	SLBB domain; Region: SLBB; pfam10531
349124000271	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349124000272	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
349124000273	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
349124000274	dimer interface [polypeptide binding]; other site
349124000275	PYR/PP interface [polypeptide binding]; other site
349124000276	TPP binding site [chemical binding]; other site
349124000277	substrate binding site [chemical binding]; other site
349124000278	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
349124000279	4Fe-4S binding domain; Region: Fer4_6; pfam12837
349124000280	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
349124000281	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
349124000282	TPP-binding site [chemical binding]; other site
349124000283	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
349124000284	ferredoxin; Validated; Region: PRK07118
349124000285	Putative Fe-S cluster; Region: FeS; cl17515
349124000286	4Fe-4S binding domain; Region: Fer4; pfam00037
349124000287	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
349124000288	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
349124000289	dimer interface [polypeptide binding]; other site
349124000290	PYR/PP interface [polypeptide binding]; other site
349124000291	TPP binding site [chemical binding]; other site
349124000292	substrate binding site [chemical binding]; other site
349124000293	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
349124000294	TPP-binding site; other site
349124000295	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
349124000296	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
349124000297	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349124000298	acyl-activating enzyme (AAE) consensus motif; other site
349124000299	AMP binding site [chemical binding]; other site
349124000300	active site
349124000301	CoA binding site [chemical binding]; other site
349124000302	ACT domain-containing protein [General function prediction only]; Region: COG4747
349124000303	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
349124000304	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
349124000305	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
349124000306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124000307	FeS/SAM binding site; other site
349124000308	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
349124000309	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
349124000310	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
349124000311	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349124000312	dimerization interface [polypeptide binding]; other site
349124000313	putative DNA binding site [nucleotide binding]; other site
349124000314	putative Zn2+ binding site [ion binding]; other site
349124000315	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349124000316	active site residue [active]
349124000317	BCCT family transporter; Region: BCCT; pfam02028
349124000318	glycerol kinase; Provisional; Region: glpK; PRK00047
349124000319	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
349124000320	N- and C-terminal domain interface [polypeptide binding]; other site
349124000321	active site
349124000322	MgATP binding site [chemical binding]; other site
349124000323	catalytic site [active]
349124000324	metal binding site [ion binding]; metal-binding site
349124000325	glycerol binding site [chemical binding]; other site
349124000326	homotetramer interface [polypeptide binding]; other site
349124000327	homodimer interface [polypeptide binding]; other site
349124000328	FBP binding site [chemical binding]; other site
349124000329	protein IIAGlc interface [polypeptide binding]; other site
349124000330	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
349124000331	PhoU domain; Region: PhoU; pfam01895
349124000332	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
349124000333	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
349124000334	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
349124000335	Predicted membrane protein [Function unknown]; Region: COG4425
349124000336	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
349124000337	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349124000338	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349124000339	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
349124000340	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
349124000341	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
349124000342	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
349124000343	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
349124000344	NAD(P) binding site [chemical binding]; other site
349124000345	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
349124000346	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
349124000347	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
349124000348	trimer interface [polypeptide binding]; other site
349124000349	active site
349124000350	UDP-GlcNAc binding site [chemical binding]; other site
349124000351	lipid binding site [chemical binding]; lipid-binding site
349124000352	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
349124000353	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
349124000354	Low molecular weight phosphatase family; Region: LMWPc; cd00115
349124000355	active site
349124000356	transcriptional regulator PhoU; Provisional; Region: PRK11115
349124000357	PhoU domain; Region: PhoU; pfam01895
349124000358	PhoU domain; Region: PhoU; pfam01895
349124000359	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
349124000360	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
349124000361	Walker A/P-loop; other site
349124000362	ATP binding site [chemical binding]; other site
349124000363	Q-loop/lid; other site
349124000364	ABC transporter signature motif; other site
349124000365	Walker B; other site
349124000366	D-loop; other site
349124000367	H-loop/switch region; other site
349124000368	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
349124000369	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
349124000370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124000371	dimer interface [polypeptide binding]; other site
349124000372	conserved gate region; other site
349124000373	putative PBP binding loops; other site
349124000374	ABC-ATPase subunit interface; other site
349124000375	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
349124000376	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
349124000377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124000378	dimer interface [polypeptide binding]; other site
349124000379	conserved gate region; other site
349124000380	putative PBP binding loops; other site
349124000381	ABC-ATPase subunit interface; other site
349124000382	PBP superfamily domain; Region: PBP_like_2; cl17296
349124000383	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
349124000384	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349124000385	PAS domain; Region: PAS_8; pfam13188
349124000386	putative active site [active]
349124000387	heme pocket [chemical binding]; other site
349124000388	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124000389	dimer interface [polypeptide binding]; other site
349124000390	phosphorylation site [posttranslational modification]
349124000391	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124000392	ATP binding site [chemical binding]; other site
349124000393	Mg2+ binding site [ion binding]; other site
349124000394	G-X-G motif; other site
349124000395	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
349124000396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124000397	active site
349124000398	phosphorylation site [posttranslational modification]
349124000399	intermolecular recognition site; other site
349124000400	dimerization interface [polypeptide binding]; other site
349124000401	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349124000402	DNA binding site [nucleotide binding]
349124000403	Yip1 domain; Region: Yip1; pfam04893
349124000404	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
349124000405	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
349124000406	catalytic triad [active]
349124000407	putative inner membrane peptidase; Provisional; Region: PRK11778
349124000408	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
349124000409	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
349124000410	tandem repeat interface [polypeptide binding]; other site
349124000411	oligomer interface [polypeptide binding]; other site
349124000412	active site residues [active]
349124000413	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
349124000414	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
349124000415	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
349124000416	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
349124000417	active site
349124000418	HIGH motif; other site
349124000419	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
349124000420	KMSKS motif; other site
349124000421	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
349124000422	tRNA binding surface [nucleotide binding]; other site
349124000423	anticodon binding site; other site
349124000424	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
349124000425	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
349124000426	HIGH motif; other site
349124000427	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349124000428	active site
349124000429	KMSKS motif; other site
349124000430	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349124000431	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
349124000432	putative active site [active]
349124000433	putative metal binding site [ion binding]; other site
349124000434	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
349124000435	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
349124000436	FMN binding site [chemical binding]; other site
349124000437	active site
349124000438	catalytic residues [active]
349124000439	substrate binding site [chemical binding]; other site
349124000440	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
349124000441	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349124000442	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349124000443	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349124000444	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349124000445	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
349124000446	putative active site [active]
349124000447	putative CoA binding site [chemical binding]; other site
349124000448	nudix motif; other site
349124000449	metal binding site [ion binding]; metal-binding site
349124000450	lipoyl synthase; Provisional; Region: PRK05481
349124000451	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124000452	FeS/SAM binding site; other site
349124000453	Protein of unknown function, DUF399; Region: DUF399; pfam04187
349124000454	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349124000455	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349124000456	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349124000457	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
349124000458	aminopeptidase N; Provisional; Region: pepN; PRK14015
349124000459	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
349124000460	active site
349124000461	Zn binding site [ion binding]; other site
349124000462	C-terminal peptidase (prc); Region: prc; TIGR00225
349124000463	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
349124000464	protein binding site [polypeptide binding]; other site
349124000465	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
349124000466	Catalytic dyad [active]
349124000467	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
349124000468	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
349124000469	DHH family; Region: DHH; pfam01368
349124000470	DHHA1 domain; Region: DHHA1; pfam02272
349124000471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
349124000472	threonine synthase; Reviewed; Region: PRK06721
349124000473	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
349124000474	homodimer interface [polypeptide binding]; other site
349124000475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124000476	catalytic residue [active]
349124000477	homoserine dehydrogenase; Provisional; Region: PRK06349
349124000478	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
349124000479	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
349124000480	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
349124000481	aminotransferase; Validated; Region: PRK08175
349124000482	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349124000483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124000484	homodimer interface [polypeptide binding]; other site
349124000485	catalytic residue [active]
349124000486	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
349124000487	CHASE domain; Region: CHASE; cl01369
349124000488	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124000489	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124000490	metal binding site [ion binding]; metal-binding site
349124000491	active site
349124000492	I-site; other site
349124000493	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
349124000494	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
349124000495	homodimer interface [polypeptide binding]; other site
349124000496	metal binding site [ion binding]; metal-binding site
349124000497	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
349124000498	homodimer interface [polypeptide binding]; other site
349124000499	active site
349124000500	putative chemical substrate binding site [chemical binding]; other site
349124000501	metal binding site [ion binding]; metal-binding site
349124000502	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349124000503	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349124000504	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
349124000505	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
349124000506	C-terminal domain interface [polypeptide binding]; other site
349124000507	GSH binding site (G-site) [chemical binding]; other site
349124000508	dimer interface [polypeptide binding]; other site
349124000509	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
349124000510	N-terminal domain interface [polypeptide binding]; other site
349124000511	dimer interface [polypeptide binding]; other site
349124000512	substrate binding pocket (H-site) [chemical binding]; other site
349124000513	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
349124000514	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
349124000515	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
349124000516	Predicted transcriptional regulator [Transcription]; Region: COG1959
349124000517	Transcriptional regulator; Region: Rrf2; cl17282
349124000518	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
349124000519	dimer interface [polypeptide binding]; other site
349124000520	substrate binding site [chemical binding]; other site
349124000521	ATP binding site [chemical binding]; other site
349124000522	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
349124000523	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
349124000524	putative AMP binding site [chemical binding]; other site
349124000525	putative active site [active]
349124000526	acyl-activating enzyme (AAE) consensus motif; other site
349124000527	putative CoA binding site [chemical binding]; other site
349124000528	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349124000529	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
349124000530	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
349124000531	ABC transporter ATPase component; Reviewed; Region: PRK11147
349124000532	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124000533	Walker A/P-loop; other site
349124000534	ATP binding site [chemical binding]; other site
349124000535	Q-loop/lid; other site
349124000536	ABC transporter signature motif; other site
349124000537	Walker B; other site
349124000538	D-loop; other site
349124000539	H-loop/switch region; other site
349124000540	ABC transporter; Region: ABC_tran_2; pfam12848
349124000541	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349124000542	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
349124000543	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
349124000544	putative active site [active]
349124000545	metal binding site [ion binding]; metal-binding site
349124000546	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
349124000547	DnaJ domain; Region: DnaJ; pfam00226
349124000548	HSP70 interaction site [polypeptide binding]; other site
349124000549	GrpE; Region: GrpE; pfam01025
349124000550	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
349124000551	dimer interface [polypeptide binding]; other site
349124000552	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
349124000553	chaperone protein DnaK; Region: prok_dnaK; TIGR02350
349124000554	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
349124000555	nucleotide binding site [chemical binding]; other site
349124000556	Double zinc ribbon; Region: DZR; pfam12773
349124000557	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
349124000558	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
349124000559	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
349124000560	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
349124000561	protein binding site [polypeptide binding]; other site
349124000562	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
349124000563	Domain interface; other site
349124000564	Peptide binding site; other site
349124000565	Active site tetrad [active]
349124000566	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
349124000567	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
349124000568	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
349124000569	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
349124000570	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
349124000571	active site
349124000572	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
349124000573	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349124000574	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
349124000575	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
349124000576	Walker A/P-loop; other site
349124000577	ATP binding site [chemical binding]; other site
349124000578	Q-loop/lid; other site
349124000579	ABC transporter signature motif; other site
349124000580	Walker B; other site
349124000581	D-loop; other site
349124000582	H-loop/switch region; other site
349124000583	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
349124000584	dimer interface [polypeptide binding]; other site
349124000585	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349124000586	active site
349124000587	metal binding site [ion binding]; metal-binding site
349124000588	glutathione binding site [chemical binding]; other site
349124000589	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
349124000590	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
349124000591	G1 box; other site
349124000592	putative GEF interaction site [polypeptide binding]; other site
349124000593	GTP/Mg2+ binding site [chemical binding]; other site
349124000594	Switch I region; other site
349124000595	G2 box; other site
349124000596	G3 box; other site
349124000597	Switch II region; other site
349124000598	G4 box; other site
349124000599	G5 box; other site
349124000600	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
349124000601	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
349124000602	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
349124000603	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
349124000604	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
349124000605	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
349124000606	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
349124000607	Protein of unknown function (DUF1305); Region: DUF1305; cl01404
349124000608	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
349124000609	Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462
349124000610	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
349124000611	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
349124000612	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
349124000613	Protein of unknown function (DUF877); Region: DUF877; pfam05943
349124000614	Protein of unknown function (DUF770); Region: DUF770; pfam05591
349124000615	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
349124000616	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
349124000617	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
349124000618	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
349124000619	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
349124000620	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
349124000621	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
349124000622	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
349124000623	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
349124000624	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349124000625	dimerization interface [polypeptide binding]; other site
349124000626	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124000627	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124000628	dimer interface [polypeptide binding]; other site
349124000629	putative CheW interface [polypeptide binding]; other site
349124000630	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
349124000631	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
349124000632	hypothetical protein; Provisional; Region: PRK06847
349124000633	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
349124000634	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349124000635	motif II; other site
349124000636	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
349124000637	active site
349124000638	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124000639	PAS domain; Region: PAS_9; pfam13426
349124000640	putative active site [active]
349124000641	heme pocket [chemical binding]; other site
349124000642	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
349124000643	GAF domain; Region: GAF; pfam01590
349124000644	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124000645	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124000646	metal binding site [ion binding]; metal-binding site
349124000647	active site
349124000648	I-site; other site
349124000649	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124000650	Protein of unknown function (DUF461); Region: DUF461; pfam04314
349124000651	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
349124000652	FOG: CBS domain [General function prediction only]; Region: COG0517
349124000653	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
349124000654	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
349124000655	acetyl-CoA synthetase; Provisional; Region: PRK04319
349124000656	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
349124000657	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
349124000658	active site
349124000659	acyl-activating enzyme (AAE) consensus motif; other site
349124000660	putative CoA binding site [chemical binding]; other site
349124000661	AMP binding site [chemical binding]; other site
349124000662	putative mechanosensitive channel protein; Provisional; Region: PRK11465
349124000663	Mechanosensitive ion channel; Region: MS_channel; pfam00924
349124000664	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
349124000665	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
349124000666	[2Fe-2S] cluster binding site [ion binding]; other site
349124000667	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
349124000668	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
349124000669	putative NAD(P) binding site [chemical binding]; other site
349124000670	putative active site [active]
349124000671	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
349124000672	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
349124000673	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
349124000674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124000675	dimer interface [polypeptide binding]; other site
349124000676	conserved gate region; other site
349124000677	putative PBP binding loops; other site
349124000678	ABC-ATPase subunit interface; other site
349124000679	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
349124000680	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124000681	Walker A/P-loop; other site
349124000682	ATP binding site [chemical binding]; other site
349124000683	Q-loop/lid; other site
349124000684	ABC transporter signature motif; other site
349124000685	Walker B; other site
349124000686	D-loop; other site
349124000687	H-loop/switch region; other site
349124000688	TOBE domain; Region: TOBE; cl01440
349124000689	Flavodoxin; Region: Flavodoxin_1; pfam00258
349124000690	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
349124000691	FAD binding pocket [chemical binding]; other site
349124000692	conserved FAD binding motif [chemical binding]; other site
349124000693	phosphate binding motif [ion binding]; other site
349124000694	beta-alpha-beta structure motif; other site
349124000695	NAD binding pocket [chemical binding]; other site
349124000696	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
349124000697	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
349124000698	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
349124000699	Predicted membrane protein [Function unknown]; Region: COG2311
349124000700	Protein of unknown function (DUF418); Region: DUF418; cl12135
349124000701	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124000702	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124000703	dimer interface [polypeptide binding]; other site
349124000704	putative CheW interface [polypeptide binding]; other site
349124000705	Cache domain; Region: Cache_1; pfam02743
349124000706	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124000707	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
349124000708	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
349124000709	Sodium Bile acid symporter family; Region: SBF; cl17470
349124000710	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349124000711	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349124000712	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
349124000713	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
349124000714	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
349124000715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
349124000716	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
349124000717	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
349124000718	Walker A/P-loop; other site
349124000719	ATP binding site [chemical binding]; other site
349124000720	Q-loop/lid; other site
349124000721	ABC transporter signature motif; other site
349124000722	Walker B; other site
349124000723	D-loop; other site
349124000724	H-loop/switch region; other site
349124000725	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
349124000726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
349124000727	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349124000728	anti sigma factor interaction site; other site
349124000729	regulatory phosphorylation site [posttranslational modification]; other site
349124000730	Response regulator receiver domain; Region: Response_reg; pfam00072
349124000731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124000732	active site
349124000733	phosphorylation site [posttranslational modification]
349124000734	intermolecular recognition site; other site
349124000735	dimerization interface [polypeptide binding]; other site
349124000736	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
349124000737	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
349124000738	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
349124000739	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349124000740	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124000741	TPR motif; other site
349124000742	binding surface
349124000743	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
349124000744	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124000745	TPR motif; other site
349124000746	binding surface
349124000747	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
349124000748	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
349124000749	DXD motif; other site
349124000750	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
349124000751	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
349124000752	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
349124000753	quinone interaction residues [chemical binding]; other site
349124000754	active site
349124000755	catalytic residues [active]
349124000756	FMN binding site [chemical binding]; other site
349124000757	substrate binding site [chemical binding]; other site
349124000758	Transglycosylase SLT domain; Region: SLT_2; pfam13406
349124000759	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349124000760	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349124000761	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
349124000762	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
349124000763	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
349124000764	C-terminal domain interface [polypeptide binding]; other site
349124000765	GSH binding site (G-site) [chemical binding]; other site
349124000766	dimer interface [polypeptide binding]; other site
349124000767	polyphosphate kinase; Provisional; Region: PRK05443
349124000768	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
349124000769	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
349124000770	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
349124000771	putative domain interface [polypeptide binding]; other site
349124000772	putative active site [active]
349124000773	catalytic site [active]
349124000774	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
349124000775	putative domain interface [polypeptide binding]; other site
349124000776	putative active site [active]
349124000777	catalytic site [active]
349124000778	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
349124000779	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
349124000780	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349124000781	catalytic core [active]
349124000782	Transcriptional regulator; Region: Rrf2; cl17282
349124000783	Rrf2 family protein; Region: rrf2_super; TIGR00738
349124000784	Protein of unknown function (DUF1249); Region: DUF1249; pfam06853
349124000785	PEP synthetase regulatory protein; Provisional; Region: PRK05339
349124000786	phosphoenolpyruvate synthase; Validated; Region: PRK06464
349124000787	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
349124000788	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349124000789	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
349124000790	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
349124000791	FAD binding domain; Region: FAD_binding_4; pfam01565
349124000792	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
349124000793	FAD binding domain; Region: FAD_binding_4; pfam01565
349124000794	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
349124000795	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349124000796	Cysteine-rich domain; Region: CCG; pfam02754
349124000797	Cysteine-rich domain; Region: CCG; pfam02754
349124000798	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
349124000799	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
349124000800	active site residue [active]
349124000801	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
349124000802	active site residue [active]
349124000803	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
349124000804	catalytic site [active]
349124000805	putative active site [active]
349124000806	putative substrate binding site [chemical binding]; other site
349124000807	dimer interface [polypeptide binding]; other site
349124000808	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
349124000809	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
349124000810	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349124000811	ligand binding site [chemical binding]; other site
349124000812	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
349124000813	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
349124000814	HDOD domain; Region: HDOD; pfam08668
349124000815	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
349124000816	nucleotide binding site/active site [active]
349124000817	HIT family signature motif; other site
349124000818	catalytic residue [active]
349124000819	recombination protein RecR; Reviewed; Region: recR; PRK00076
349124000820	RecR protein; Region: RecR; pfam02132
349124000821	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
349124000822	putative active site [active]
349124000823	putative metal-binding site [ion binding]; other site
349124000824	tetramer interface [polypeptide binding]; other site
349124000825	hypothetical protein; Validated; Region: PRK00153
349124000826	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
349124000827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124000828	Walker A motif; other site
349124000829	ATP binding site [chemical binding]; other site
349124000830	Walker B motif; other site
349124000831	arginine finger; other site
349124000832	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
349124000833	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
349124000834	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
349124000835	Walker A/P-loop; other site
349124000836	ATP binding site [chemical binding]; other site
349124000837	Q-loop/lid; other site
349124000838	ABC transporter signature motif; other site
349124000839	Walker B; other site
349124000840	D-loop; other site
349124000841	H-loop/switch region; other site
349124000842	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
349124000843	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
349124000844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124000845	dimer interface [polypeptide binding]; other site
349124000846	conserved gate region; other site
349124000847	putative PBP binding loops; other site
349124000848	ABC-ATPase subunit interface; other site
349124000849	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
349124000850	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
349124000851	BCCT family transporter; Region: BCCT; pfam02028
349124000852	ABC-2 type transporter; Region: ABC2_membrane; cl17235
349124000853	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
349124000854	nodulation ABC transporter NodI; Provisional; Region: PRK13537
349124000855	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349124000856	Walker A/P-loop; other site
349124000857	ATP binding site [chemical binding]; other site
349124000858	Q-loop/lid; other site
349124000859	ABC transporter signature motif; other site
349124000860	Walker B; other site
349124000861	D-loop; other site
349124000862	H-loop/switch region; other site
349124000863	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
349124000864	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
349124000865	GTP binding site; other site
349124000866	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
349124000867	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
349124000868	dimer interface [polypeptide binding]; other site
349124000869	putative functional site; other site
349124000870	putative MPT binding site; other site
349124000871	Predicted deacylase [General function prediction only]; Region: COG3608
349124000872	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
349124000873	putative active site [active]
349124000874	Zn binding site [ion binding]; other site
349124000875	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
349124000876	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
349124000877	RimK-like ATP-grasp domain; Region: RimK; pfam08443
349124000878	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
349124000879	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
349124000880	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
349124000881	VWA-like domain (DUF2201); Region: DUF2201; pfam09967
349124000882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349124000883	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
349124000884	gating phenylalanine in ion channel; other site
349124000885	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
349124000886	CoA binding domain; Region: CoA_binding_2; pfam13380
349124000887	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
349124000888	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
349124000889	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349124000890	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349124000891	Coenzyme A binding pocket [chemical binding]; other site
349124000892	Phosphopantetheine attachment site; Region: PP-binding; cl09936
349124000893	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
349124000894	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
349124000895	active site
349124000896	quinolinate synthetase; Provisional; Region: PRK09375
349124000897	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
349124000898	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
349124000899	putative MPT binding site; other site
349124000900	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349124000901	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
349124000902	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349124000903	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
349124000904	HlyD family secretion protein; Region: HlyD_3; pfam13437
349124000905	Protein of unknown function (DUF523); Region: DUF523; pfam04463
349124000906	Uncharacterized conserved protein [Function unknown]; Region: COG3272
349124000907	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
349124000908	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
349124000909	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349124000910	motif II; other site
349124000911	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
349124000912	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
349124000913	active site
349124000914	catalytic site [active]
349124000915	substrate binding site [chemical binding]; other site
349124000916	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
349124000917	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
349124000918	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
349124000919	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
349124000920	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
349124000921	Protein of unknown function, DUF269; Region: DUF269; pfam03270
349124000922	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124000923	Ligand Binding Site [chemical binding]; other site
349124000924	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124000925	Ligand Binding Site [chemical binding]; other site
349124000926	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
349124000927	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349124000928	catalytic loop [active]
349124000929	iron binding site [ion binding]; other site
349124000930	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
349124000931	4Fe-4S binding domain; Region: Fer4; cl02805
349124000932	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
349124000933	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
349124000934	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
349124000935	MoFe protein beta/alpha subunit interactions; other site
349124000936	Beta subunit P cluster binding residues; other site
349124000937	MoFe protein beta subunit/Fe protein contacts; other site
349124000938	MoFe protein dimer/ dimer interactions; other site
349124000939	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
349124000940	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
349124000941	MoFe protein alpha/beta subunit interactions; other site
349124000942	Alpha subunit P cluster binding residues; other site
349124000943	FeMoco binding residues [chemical binding]; other site
349124000944	MoFe protein alpha subunit/Fe protein contacts; other site
349124000945	MoFe protein dimer/ dimer interactions; other site
349124000946	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
349124000947	nitrogenase iron protein; Region: nifH; TIGR01287
349124000948	Nucleotide-binding sites [chemical binding]; other site
349124000949	Walker A motif; other site
349124000950	Switch I region of nucleotide binding site; other site
349124000951	Fe4S4 binding sites [ion binding]; other site
349124000952	Switch II region of nucleotide binding site; other site
349124000953	Protein of unknown function, DUF; Region: DUF411; cl01142
349124000954	SIR2-like domain; Region: SIR2_2; pfam13289
349124000955	NifZ domain; Region: NifZ; pfam04319
349124000956	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
349124000957	Nitrogen fixation protein NifW; Region: NifW; pfam03206
349124000958	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
349124000959	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
349124000960	active site
349124000961	catalytic residues [active]
349124000962	metal binding site [ion binding]; metal-binding site
349124000963	NifQ; Region: NifQ; pfam04891
349124000964	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124000965	Radical SAM superfamily; Region: Radical_SAM; pfam04055
349124000966	FeS/SAM binding site; other site
349124000967	Nif-specific regulatory protein; Region: nifA; TIGR01817
349124000968	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
349124000969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124000970	Walker A motif; other site
349124000971	ATP binding site [chemical binding]; other site
349124000972	Walker B motif; other site
349124000973	arginine finger; other site
349124000974	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349124000975	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
349124000976	electron transport complex protein RnfB; Provisional; Region: PRK05113
349124000977	Putative Fe-S cluster; Region: FeS; cl17515
349124000978	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
349124000979	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
349124000980	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
349124000981	SLBB domain; Region: SLBB; pfam10531
349124000982	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349124000983	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
349124000984	FMN-binding domain; Region: FMN_bind; cl01081
349124000985	electron transport complex RsxE subunit; Provisional; Region: PRK12405
349124000986	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
349124000987	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
349124000988	LPP20 lipoprotein; Region: LPP20; pfam02169
349124000989	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
349124000990	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349124000991	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349124000992	catalytic residue [active]
349124000993	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
349124000994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124000995	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
349124000996	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
349124000997	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349124000998	Zn2+ binding site [ion binding]; other site
349124000999	Mg2+ binding site [ion binding]; other site
349124001000	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349124001001	CHASE2 domain; Region: CHASE2; pfam05226
349124001002	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
349124001003	cyclase homology domain; Region: CHD; cd07302
349124001004	nucleotidyl binding site; other site
349124001005	metal binding site [ion binding]; metal-binding site
349124001006	dimer interface [polypeptide binding]; other site
349124001007	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349124001008	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124001009	TPR motif; other site
349124001010	binding surface
349124001011	FecR protein; Region: FecR; pfam04773
349124001012	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
349124001013	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
349124001014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
349124001015	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
349124001016	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
349124001017	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
349124001018	Uncharacterized conserved protein [Function unknown]; Region: COG2308
349124001019	arsenical pump membrane protein; Provisional; Region: PRK15445
349124001020	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
349124001021	transmembrane helices; other site
349124001022	hypothetical protein; Validated; Region: PRK00029
349124001023	Uncharacterized conserved protein [Function unknown]; Region: COG0397
349124001024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001025	PAS domain; Region: PAS_9; pfam13426
349124001026	putative active site [active]
349124001027	heme pocket [chemical binding]; other site
349124001028	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
349124001029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001030	putative active site [active]
349124001031	heme pocket [chemical binding]; other site
349124001032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124001033	dimer interface [polypeptide binding]; other site
349124001034	phosphorylation site [posttranslational modification]
349124001035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124001036	ATP binding site [chemical binding]; other site
349124001037	Mg2+ binding site [ion binding]; other site
349124001038	G-X-G motif; other site
349124001039	Response regulator receiver domain; Region: Response_reg; pfam00072
349124001040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001041	active site
349124001042	phosphorylation site [posttranslational modification]
349124001043	intermolecular recognition site; other site
349124001044	dimerization interface [polypeptide binding]; other site
349124001045	PAS domain; Region: PAS_9; pfam13426
349124001046	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001047	PAS fold; Region: PAS_3; pfam08447
349124001048	putative active site [active]
349124001049	heme pocket [chemical binding]; other site
349124001050	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124001051	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124001052	metal binding site [ion binding]; metal-binding site
349124001053	active site
349124001054	I-site; other site
349124001055	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
349124001056	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349124001057	Walker A motif; other site
349124001058	ATP binding site [chemical binding]; other site
349124001059	Walker B motif; other site
349124001060	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
349124001061	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
349124001062	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
349124001063	Walker A motif; other site
349124001064	ATP binding site [chemical binding]; other site
349124001065	Walker B motif; other site
349124001066	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
349124001067	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
349124001068	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349124001069	integron integrase; Region: integrase_gron; TIGR02249
349124001070	active site
349124001071	Int/Topo IB signature motif; other site
349124001072	DNA binding site [nucleotide binding]
349124001073	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
349124001074	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349124001075	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349124001076	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
349124001077	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
349124001078	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
349124001079	Walker A motif; other site
349124001080	ATP binding site [chemical binding]; other site
349124001081	Walker B motif; other site
349124001082	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124001083	binding surface
349124001084	TPR motif; other site
349124001085	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124001086	TPR motif; other site
349124001087	binding surface
349124001088	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
349124001089	AAA ATPase domain; Region: AAA_16; pfam13191
349124001090	Walker A motif; other site
349124001091	ATP binding site [chemical binding]; other site
349124001092	Walker B motif; other site
349124001093	arginine finger; other site
349124001094	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
349124001095	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
349124001096	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349124001097	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
349124001098	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124001099	metal binding site [ion binding]; metal-binding site
349124001100	active site
349124001101	I-site; other site
349124001102	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124001103	BCCT family transporter; Region: BCCT; pfam02028
349124001104	PAS domain; Region: PAS_9; pfam13426
349124001105	PAS domain S-box; Region: sensory_box; TIGR00229
349124001106	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001107	putative active site [active]
349124001108	heme pocket [chemical binding]; other site
349124001109	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124001110	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124001111	dimer interface [polypeptide binding]; other site
349124001112	phosphorylation site [posttranslational modification]
349124001113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124001114	ATP binding site [chemical binding]; other site
349124001115	Mg2+ binding site [ion binding]; other site
349124001116	G-X-G motif; other site
349124001117	Response regulator receiver domain; Region: Response_reg; pfam00072
349124001118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001119	active site
349124001120	phosphorylation site [posttranslational modification]
349124001121	intermolecular recognition site; other site
349124001122	dimerization interface [polypeptide binding]; other site
349124001123	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
349124001124	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
349124001125	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349124001126	ligand binding site [chemical binding]; other site
349124001127	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
349124001128	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
349124001129	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
349124001130	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
349124001131	putative active site [active]
349124001132	catalytic site [active]
349124001133	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
349124001134	PLD-like domain; Region: PLDc_2; pfam13091
349124001135	putative active site [active]
349124001136	catalytic site [active]
349124001137	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
349124001138	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349124001139	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
349124001140	substrate binding site [chemical binding]; other site
349124001141	dimerization interface [polypeptide binding]; other site
349124001142	putative inner membrane protein; Provisional; Region: PRK11099
349124001143	putative inner membrane protein; Provisional; Region: PRK11099
349124001144	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001145	PAS domain; Region: PAS_9; pfam13426
349124001146	putative active site [active]
349124001147	PAS domain S-box; Region: sensory_box; TIGR00229
349124001148	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001149	putative active site [active]
349124001150	heme pocket [chemical binding]; other site
349124001151	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001152	PAS domain; Region: PAS_9; pfam13426
349124001153	putative active site [active]
349124001154	heme pocket [chemical binding]; other site
349124001155	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124001156	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124001157	metal binding site [ion binding]; metal-binding site
349124001158	active site
349124001159	I-site; other site
349124001160	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124001161	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
349124001162	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349124001163	motif II; other site
349124001164	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
349124001165	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
349124001166	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
349124001167	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
349124001168	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
349124001169	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
349124001170	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
349124001171	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
349124001172	transmembrane helices; other site
349124001173	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
349124001174	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
349124001175	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
349124001176	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349124001177	active site residue [active]
349124001178	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
349124001179	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349124001180	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
349124001181	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349124001182	molybdopterin cofactor binding site; other site
349124001183	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349124001184	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
349124001185	molybdopterin cofactor binding site; other site
349124001186	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
349124001187	4Fe-4S binding domain; Region: Fer4; pfam00037
349124001188	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
349124001189	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
349124001190	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
349124001191	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
349124001192	membrane-bound complex binding site; other site
349124001193	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
349124001194	DctM-like transporters; Region: DctM; pfam06808
349124001195	Predicted permeases [General function prediction only]; Region: COG0679
349124001196	PAS domain S-box; Region: sensory_box; TIGR00229
349124001197	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001198	putative active site [active]
349124001199	heme pocket [chemical binding]; other site
349124001200	PAS domain; Region: PAS_9; pfam13426
349124001201	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001202	putative active site [active]
349124001203	heme pocket [chemical binding]; other site
349124001204	PAS fold; Region: PAS; pfam00989
349124001205	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001206	putative active site [active]
349124001207	heme pocket [chemical binding]; other site
349124001208	PAS domain; Region: PAS_9; pfam13426
349124001209	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001210	putative active site [active]
349124001211	heme pocket [chemical binding]; other site
349124001212	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124001213	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124001214	dimer interface [polypeptide binding]; other site
349124001215	phosphorylation site [posttranslational modification]
349124001216	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124001217	ATP binding site [chemical binding]; other site
349124001218	Mg2+ binding site [ion binding]; other site
349124001219	G-X-G motif; other site
349124001220	Response regulator receiver domain; Region: Response_reg; pfam00072
349124001221	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001222	active site
349124001223	phosphorylation site [posttranslational modification]
349124001224	intermolecular recognition site; other site
349124001225	dimerization interface [polypeptide binding]; other site
349124001226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124001227	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349124001228	S-adenosylmethionine binding site [chemical binding]; other site
349124001229	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
349124001230	PAS fold; Region: PAS_4; pfam08448
349124001231	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124001232	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124001233	metal binding site [ion binding]; metal-binding site
349124001234	active site
349124001235	I-site; other site
349124001236	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124001237	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349124001238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001239	active site
349124001240	phosphorylation site [posttranslational modification]
349124001241	intermolecular recognition site; other site
349124001242	dimerization interface [polypeptide binding]; other site
349124001243	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124001244	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124001245	metal binding site [ion binding]; metal-binding site
349124001246	active site
349124001247	I-site; other site
349124001248	PAS domain S-box; Region: sensory_box; TIGR00229
349124001249	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001250	putative active site [active]
349124001251	heme pocket [chemical binding]; other site
349124001252	PAS domain S-box; Region: sensory_box; TIGR00229
349124001253	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001254	putative active site [active]
349124001255	heme pocket [chemical binding]; other site
349124001256	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001257	PAS fold; Region: PAS_3; pfam08447
349124001258	putative active site [active]
349124001259	heme pocket [chemical binding]; other site
349124001260	PAS domain S-box; Region: sensory_box; TIGR00229
349124001261	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124001262	putative active site [active]
349124001263	heme pocket [chemical binding]; other site
349124001264	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124001265	dimer interface [polypeptide binding]; other site
349124001266	phosphorylation site [posttranslational modification]
349124001267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124001268	ATP binding site [chemical binding]; other site
349124001269	Mg2+ binding site [ion binding]; other site
349124001270	G-X-G motif; other site
349124001271	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001272	Response regulator receiver domain; Region: Response_reg; pfam00072
349124001273	active site
349124001274	phosphorylation site [posttranslational modification]
349124001275	intermolecular recognition site; other site
349124001276	dimerization interface [polypeptide binding]; other site
349124001277	Response regulator receiver domain; Region: Response_reg; pfam00072
349124001278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001279	active site
349124001280	phosphorylation site [posttranslational modification]
349124001281	intermolecular recognition site; other site
349124001282	dimerization interface [polypeptide binding]; other site
349124001283	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349124001284	putative binding surface; other site
349124001285	active site
349124001286	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
349124001287	PAS fold; Region: PAS_3; pfam08447
349124001288	putative active site [active]
349124001289	heme pocket [chemical binding]; other site
349124001290	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124001291	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
349124001292	dimer interface [polypeptide binding]; other site
349124001293	phosphorylation site [posttranslational modification]
349124001294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124001295	ATP binding site [chemical binding]; other site
349124001296	Mg2+ binding site [ion binding]; other site
349124001297	G-X-G motif; other site
349124001298	Response regulator receiver domain; Region: Response_reg; pfam00072
349124001299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001300	active site
349124001301	phosphorylation site [posttranslational modification]
349124001302	intermolecular recognition site; other site
349124001303	dimerization interface [polypeptide binding]; other site
349124001304	BON domain; Region: BON; pfam04972
349124001305	PAS domain; Region: PAS; smart00091
349124001306	PAS fold; Region: PAS_4; pfam08448
349124001307	putative active site [active]
349124001308	heme pocket [chemical binding]; other site
349124001309	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
349124001310	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
349124001311	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
349124001312	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
349124001313	PAS domain; Region: PAS_10; pfam13596
349124001314	LysE type translocator; Region: LysE; cl00565
349124001315	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
349124001316	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349124001317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
349124001318	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
349124001319	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
349124001320	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
349124001321	hydrophobic ligand binding site; other site
349124001322	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
349124001323	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
349124001324	Walker A/P-loop; other site
349124001325	ATP binding site [chemical binding]; other site
349124001326	Q-loop/lid; other site
349124001327	ABC transporter signature motif; other site
349124001328	Walker B; other site
349124001329	D-loop; other site
349124001330	H-loop/switch region; other site
349124001331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124001332	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
349124001333	Walker A/P-loop; other site
349124001334	ATP binding site [chemical binding]; other site
349124001335	Q-loop/lid; other site
349124001336	ABC transporter signature motif; other site
349124001337	Walker B; other site
349124001338	D-loop; other site
349124001339	H-loop/switch region; other site
349124001340	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
349124001341	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
349124001342	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
349124001343	NAD(P) binding site [chemical binding]; other site
349124001344	NADH(P)-binding; Region: NAD_binding_10; pfam13460
349124001345	putative active site [active]
349124001346	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
349124001347	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
349124001348	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124001349	FeS/SAM binding site; other site
349124001350	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
349124001351	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349124001352	N-terminal plug; other site
349124001353	ligand-binding site [chemical binding]; other site
349124001354	Hemin uptake protein hemP; Region: hemP; pfam10636
349124001355	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
349124001356	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
349124001357	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349124001358	N-terminal plug; other site
349124001359	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
349124001360	ligand-binding site [chemical binding]; other site
349124001361	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
349124001362	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
349124001363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349124001364	putative substrate translocation pore; other site
349124001365	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
349124001366	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349124001367	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349124001368	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
349124001369	Protein of unknown function (DUF3185); Region: DUF3185; pfam11381
349124001370	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349124001371	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
349124001372	ligand binding site [chemical binding]; other site
349124001373	flexible hinge region; other site
349124001374	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349124001375	non-specific DNA interactions [nucleotide binding]; other site
349124001376	DNA binding site [nucleotide binding]
349124001377	sequence specific DNA binding site [nucleotide binding]; other site
349124001378	putative cAMP binding site [chemical binding]; other site
349124001379	Fatty acid desaturase; Region: FA_desaturase; pfam00487
349124001380	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
349124001381	putative di-iron ligands [ion binding]; other site
349124001382	pyruvate carboxylase; Reviewed; Region: PRK12999
349124001383	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349124001384	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
349124001385	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
349124001386	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
349124001387	active site
349124001388	catalytic residues [active]
349124001389	metal binding site [ion binding]; metal-binding site
349124001390	homodimer binding site [polypeptide binding]; other site
349124001391	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349124001392	carboxyltransferase (CT) interaction site; other site
349124001393	biotinylation site [posttranslational modification]; other site
349124001394	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349124001395	SOUL heme-binding protein; Region: SOUL; pfam04832
349124001396	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
349124001397	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
349124001398	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
349124001399	EcoRII C terminal; Region: EcoRII-C; pfam09019
349124001400	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
349124001401	additional DNA contacts [nucleotide binding]; other site
349124001402	mismatch recognition site; other site
349124001403	active site
349124001404	zinc binding site [ion binding]; other site
349124001405	DNA intercalation site [nucleotide binding]; other site
349124001406	DNA cytosine methylase; Provisional; Region: PRK10458
349124001407	Homeodomain-like domain; Region: HTH_23; pfam13384
349124001408	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
349124001409	cofactor binding site; other site
349124001410	DNA binding site [nucleotide binding]
349124001411	substrate interaction site [chemical binding]; other site
349124001412	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349124001413	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349124001414	non-specific DNA binding site [nucleotide binding]; other site
349124001415	salt bridge; other site
349124001416	sequence-specific DNA binding site [nucleotide binding]; other site
349124001417	HNH endonuclease; Region: HNH_2; pfam13391
349124001418	Transposase domain (DUF772); Region: DUF772; pfam05598
349124001419	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
349124001420	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
349124001421	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
349124001422	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
349124001423	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
349124001424	Nuclease-related domain; Region: NERD; pfam08378
349124001425	Family description; Region: UvrD_C_2; pfam13538
349124001426	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
349124001427	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
349124001428	putative active site pocket [active]
349124001429	dimerization interface [polypeptide binding]; other site
349124001430	putative catalytic residue [active]
349124001431	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
349124001432	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
349124001433	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
349124001434	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
349124001435	active site
349124001436	dimer interface [polypeptide binding]; other site
349124001437	motif 1; other site
349124001438	motif 2; other site
349124001439	motif 3; other site
349124001440	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
349124001441	anticodon binding site; other site
349124001442	translation initiation factor IF-3; Region: infC; TIGR00168
349124001443	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
349124001444	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
349124001445	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
349124001446	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
349124001447	23S rRNA binding site [nucleotide binding]; other site
349124001448	L21 binding site [polypeptide binding]; other site
349124001449	L13 binding site [polypeptide binding]; other site
349124001450	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
349124001451	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
349124001452	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
349124001453	dimer interface [polypeptide binding]; other site
349124001454	motif 1; other site
349124001455	active site
349124001456	motif 2; other site
349124001457	motif 3; other site
349124001458	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
349124001459	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
349124001460	putative tRNA-binding site [nucleotide binding]; other site
349124001461	B3/4 domain; Region: B3_4; pfam03483
349124001462	tRNA synthetase B5 domain; Region: B5; smart00874
349124001463	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
349124001464	dimer interface [polypeptide binding]; other site
349124001465	motif 1; other site
349124001466	motif 3; other site
349124001467	motif 2; other site
349124001468	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
349124001469	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349124001470	IHF dimer interface [polypeptide binding]; other site
349124001471	IHF - DNA interface [nucleotide binding]; other site
349124001472	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
349124001473	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
349124001474	DNA binding residues [nucleotide binding]
349124001475	Putative zinc-finger; Region: zf-HC2; pfam13490
349124001476	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
349124001477	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349124001478	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349124001479	DNA binding residues [nucleotide binding]
349124001480	Bifunctional NADH kinase/NAD(+) kinase; Region: PLN02935
349124001481	H-NS histone family; Region: Histone_HNS; pfam00816
349124001482	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
349124001483	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
349124001484	transmembrane helices; other site
349124001485	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
349124001486	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
349124001487	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349124001488	dimerization interface [polypeptide binding]; other site
349124001489	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124001490	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124001491	dimer interface [polypeptide binding]; other site
349124001492	putative CheW interface [polypeptide binding]; other site
349124001493	signal recognition particle protein; Provisional; Region: PRK10867
349124001494	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
349124001495	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
349124001496	P loop; other site
349124001497	GTP binding site [chemical binding]; other site
349124001498	Signal peptide binding domain; Region: SRP_SPB; pfam02978
349124001499	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
349124001500	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
349124001501	putative catalytic residue [active]
349124001502	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
349124001503	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
349124001504	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
349124001505	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
349124001506	DctM-like transporters; Region: DctM; pfam06808
349124001507	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
349124001508	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
349124001509	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
349124001510	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
349124001511	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
349124001512	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
349124001513	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
349124001514	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
349124001515	hypothetical protein; Provisional; Region: PRK10279
349124001516	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
349124001517	active site
349124001518	nucleophile elbow; other site
349124001519	TSCPD domain; Region: TSCPD; pfam12637
349124001520	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
349124001521	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
349124001522	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
349124001523	active site
349124001524	dimer interface [polypeptide binding]; other site
349124001525	effector binding site; other site
349124001526	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
349124001527	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
349124001528	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349124001529	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
349124001530	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
349124001531	Soluble P-type ATPase [General function prediction only]; Region: COG4087
349124001532	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
349124001533	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
349124001534	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
349124001535	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
349124001536	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
349124001537	putative active site [active]
349124001538	putative PHP Thumb interface [polypeptide binding]; other site
349124001539	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
349124001540	generic binding surface II; other site
349124001541	generic binding surface I; other site
349124001542	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349124001543	RNA binding surface [nucleotide binding]; other site
349124001544	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
349124001545	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124001546	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124001547	metal binding site [ion binding]; metal-binding site
349124001548	active site
349124001549	I-site; other site
349124001550	ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326
349124001551	Ribulose bisphosphate carboxylase like proteins (RLPs) similar to R.rubrum RLP; Region: RLP_RrRLP; cd08210
349124001552	dimer interface [polypeptide binding]; other site
349124001553	active site
349124001554	catalytic residue [active]
349124001555	metal binding site [ion binding]; metal-binding site
349124001556	Cupin domain; Region: Cupin_2; pfam07883
349124001557	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
349124001558	Domain of unknown function DUF21; Region: DUF21; pfam01595
349124001559	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
349124001560	Transporter associated domain; Region: CorC_HlyC; smart01091
349124001561	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
349124001562	putative CheA interaction surface; other site
349124001563	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
349124001564	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349124001565	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349124001566	P-loop; other site
349124001567	Magnesium ion binding site [ion binding]; other site
349124001568	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349124001569	Magnesium ion binding site [ion binding]; other site
349124001570	Response regulator receiver domain; Region: Response_reg; pfam00072
349124001571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001572	active site
349124001573	phosphorylation site [posttranslational modification]
349124001574	intermolecular recognition site; other site
349124001575	dimerization interface [polypeptide binding]; other site
349124001576	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
349124001577	CheB methylesterase; Region: CheB_methylest; pfam01339
349124001578	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349124001579	putative binding surface; other site
349124001580	active site
349124001581	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
349124001582	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
349124001583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124001584	ATP binding site [chemical binding]; other site
349124001585	Mg2+ binding site [ion binding]; other site
349124001586	G-X-G motif; other site
349124001587	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
349124001588	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
349124001589	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
349124001590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001591	active site
349124001592	phosphorylation site [posttranslational modification]
349124001593	intermolecular recognition site; other site
349124001594	dimerization interface [polypeptide binding]; other site
349124001595	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
349124001596	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349124001597	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
349124001598	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349124001599	DNA binding residues [nucleotide binding]
349124001600	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349124001601	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
349124001602	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
349124001603	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
349124001604	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
349124001605	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349124001606	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
349124001607	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
349124001608	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
349124001609	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
349124001610	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
349124001611	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
349124001612	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
349124001613	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
349124001614	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
349124001615	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
349124001616	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
349124001617	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
349124001618	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
349124001619	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
349124001620	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
349124001621	intersubunit interface [polypeptide binding]; other site
349124001622	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
349124001623	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349124001624	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
349124001625	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
349124001626	Flagellar FliJ protein; Region: FliJ; pfam02050
349124001627	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
349124001628	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
349124001629	Walker A motif/ATP binding site; other site
349124001630	Walker B motif; other site
349124001631	flagellar assembly protein H; Validated; Region: fliH; PRK05687
349124001632	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
349124001633	Flagellar assembly protein FliH; Region: FliH; pfam02108
349124001634	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
349124001635	MgtE intracellular N domain; Region: MgtE_N; smart00924
349124001636	FliG C-terminal domain; Region: FliG_C; pfam01706
349124001637	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
349124001638	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
349124001639	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
349124001640	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
349124001641	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349124001642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001643	active site
349124001644	phosphorylation site [posttranslational modification]
349124001645	intermolecular recognition site; other site
349124001646	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124001647	Walker A motif; other site
349124001648	ATP binding site [chemical binding]; other site
349124001649	Walker B motif; other site
349124001650	arginine finger; other site
349124001651	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349124001652	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349124001653	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
349124001654	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124001655	Walker A motif; other site
349124001656	ATP binding site [chemical binding]; other site
349124001657	Walker B motif; other site
349124001658	arginine finger; other site
349124001659	Flagellar protein FliT; Region: FliT; pfam05400
349124001660	flagellar protein FliS; Validated; Region: fliS; PRK05685
349124001661	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
349124001662	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
349124001663	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
349124001664	FlaG protein; Region: FlaG; pfam03646
349124001665	flagellin; Provisional; Region: PRK12806
349124001666	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
349124001667	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
349124001668	flagellin; Provisional; Region: PRK12806
349124001669	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
349124001670	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
349124001671	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
349124001672	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349124001673	N-terminal plug; other site
349124001674	ligand-binding site [chemical binding]; other site
349124001675	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
349124001676	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
349124001677	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
349124001678	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
349124001679	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349124001680	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349124001681	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
349124001682	Rod binding protein; Region: Rod-binding; cl01626
349124001683	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
349124001684	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
349124001685	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
349124001686	Flagellar L-ring protein; Region: FlgH; pfam02107
349124001687	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
349124001688	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349124001689	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349124001690	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
349124001691	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349124001692	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
349124001693	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349124001694	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
349124001695	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349124001696	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
349124001697	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
349124001698	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
349124001699	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
349124001700	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
349124001701	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
349124001702	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
349124001703	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
349124001704	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
349124001705	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
349124001706	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
349124001707	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
349124001708	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349124001709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124001710	active site
349124001711	phosphorylation site [posttranslational modification]
349124001712	intermolecular recognition site; other site
349124001713	dimerization interface [polypeptide binding]; other site
349124001714	SAF-like; Region: SAF_2; pfam13144
349124001715	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
349124001716	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
349124001717	FlgN protein; Region: FlgN; pfam05130
349124001718	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
349124001719	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
349124001720	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
349124001721	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
349124001722	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
349124001723	DEAD_2; Region: DEAD_2; pfam06733
349124001724	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
349124001725	TPR repeat; Region: TPR_11; pfam13414
349124001726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124001727	binding surface
349124001728	TPR motif; other site
349124001729	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124001730	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124001731	dimer interface [polypeptide binding]; other site
349124001732	putative CheW interface [polypeptide binding]; other site
349124001733	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
349124001734	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124001735	dimer interface [polypeptide binding]; other site
349124001736	putative CheW interface [polypeptide binding]; other site
349124001737	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
349124001738	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
349124001739	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349124001740	catalytic residue [active]
349124001741	FeS assembly protein SufD; Region: sufD; TIGR01981
349124001742	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
349124001743	FeS assembly ATPase SufC; Region: sufC; TIGR01978
349124001744	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
349124001745	Walker A/P-loop; other site
349124001746	ATP binding site [chemical binding]; other site
349124001747	Q-loop/lid; other site
349124001748	ABC transporter signature motif; other site
349124001749	Walker B; other site
349124001750	D-loop; other site
349124001751	H-loop/switch region; other site
349124001752	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
349124001753	putative ABC transporter; Region: ycf24; CHL00085
349124001754	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
349124001755	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349124001756	dimerization interface [polypeptide binding]; other site
349124001757	putative Zn2+ binding site [ion binding]; other site
349124001758	putative DNA binding site [nucleotide binding]; other site
349124001759	Transcriptional regulator; Region: Rrf2; cl17282
349124001760	excinuclease ABC subunit B; Provisional; Region: PRK05298
349124001761	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349124001762	ATP binding site [chemical binding]; other site
349124001763	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349124001764	nucleotide binding region [chemical binding]; other site
349124001765	ATP-binding site [chemical binding]; other site
349124001766	Ultra-violet resistance protein B; Region: UvrB; pfam12344
349124001767	UvrB/uvrC motif; Region: UVR; pfam02151
349124001768	aspartate aminotransferase; Provisional; Region: PRK05764
349124001769	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349124001770	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124001771	homodimer interface [polypeptide binding]; other site
349124001772	catalytic residue [active]
349124001773	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
349124001774	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349124001775	catalytic loop [active]
349124001776	iron binding site [ion binding]; other site
349124001777	Dodecin; Region: Dodecin; pfam07311
349124001778	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
349124001779	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
349124001780	dimer interface [polypeptide binding]; other site
349124001781	active site
349124001782	heme binding site [chemical binding]; other site
349124001783	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
349124001784	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
349124001785	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349124001786	dimerization interface [polypeptide binding]; other site
349124001787	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124001788	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124001789	dimer interface [polypeptide binding]; other site
349124001790	putative CheW interface [polypeptide binding]; other site
349124001791	classical (c) SDRs; Region: SDR_c; cd05233
349124001792	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
349124001793	NAD(P) binding site [chemical binding]; other site
349124001794	active site
349124001795	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
349124001796	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349124001797	N-terminal plug; other site
349124001798	ligand-binding site [chemical binding]; other site
349124001799	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
349124001800	homodimer interaction site [polypeptide binding]; other site
349124001801	cofactor binding site; other site
349124001802	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
349124001803	Cation efflux family; Region: Cation_efflux; pfam01545
349124001804	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
349124001805	Na binding site [ion binding]; other site
349124001806	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
349124001807	Proline dehydrogenase; Region: Pro_dh; pfam01619
349124001808	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
349124001809	Glutamate binding site [chemical binding]; other site
349124001810	NAD binding site [chemical binding]; other site
349124001811	catalytic residues [active]
349124001812	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
349124001813	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
349124001814	dimer interface [polypeptide binding]; other site
349124001815	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124001816	catalytic residue [active]
349124001817	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
349124001818	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
349124001819	homotetramer interface [polypeptide binding]; other site
349124001820	NAD(P) binding site [chemical binding]; other site
349124001821	homodimer interface [polypeptide binding]; other site
349124001822	active site
349124001823	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
349124001824	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
349124001825	active site
349124001826	dimer interface [polypeptide binding]; other site
349124001827	tetratricopeptide repeat protein; Provisional; Region: PRK11788
349124001828	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124001829	binding surface
349124001830	TPR motif; other site
349124001831	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124001832	binding surface
349124001833	TPR motif; other site
349124001834	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
349124001835	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349124001836	IHF dimer interface [polypeptide binding]; other site
349124001837	IHF - DNA interface [nucleotide binding]; other site
349124001838	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
349124001839	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
349124001840	RNA binding site [nucleotide binding]; other site
349124001841	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
349124001842	RNA binding site [nucleotide binding]; other site
349124001843	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
349124001844	RNA binding site [nucleotide binding]; other site
349124001845	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
349124001846	RNA binding site [nucleotide binding]; other site
349124001847	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
349124001848	RNA binding site [nucleotide binding]; other site
349124001849	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
349124001850	RNA binding site [nucleotide binding]; other site
349124001851	cytidylate kinase; Provisional; Region: cmk; PRK00023
349124001852	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
349124001853	CMP-binding site; other site
349124001854	The sites determining sugar specificity; other site
349124001855	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
349124001856	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
349124001857	hinge; other site
349124001858	active site
349124001859	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
349124001860	prephenate dehydrogenase; Validated; Region: PRK08507
349124001861	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
349124001862	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349124001863	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124001864	homodimer interface [polypeptide binding]; other site
349124001865	catalytic residue [active]
349124001866	Chorismate mutase type II; Region: CM_2; pfam01817
349124001867	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
349124001868	Prephenate dehydratase; Region: PDT; pfam00800
349124001869	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
349124001870	putative L-Phe binding site [chemical binding]; other site
349124001871	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
349124001872	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
349124001873	putative ligand binding site [chemical binding]; other site
349124001874	putative NAD binding site [chemical binding]; other site
349124001875	putative catalytic site [active]
349124001876	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
349124001877	L-serine binding site [chemical binding]; other site
349124001878	ACT domain interface; other site
349124001879	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
349124001880	homodimer interface [polypeptide binding]; other site
349124001881	substrate-cofactor binding pocket; other site
349124001882	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124001883	catalytic residue [active]
349124001884	DNA gyrase subunit A; Validated; Region: PRK05560
349124001885	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
349124001886	CAP-like domain; other site
349124001887	active site
349124001888	primary dimer interface [polypeptide binding]; other site
349124001889	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349124001890	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349124001891	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349124001892	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349124001893	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349124001894	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349124001895	potassium/proton antiporter; Reviewed; Region: PRK05326
349124001896	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
349124001897	TrkA-C domain; Region: TrkA_C; pfam02080
349124001898	Transporter associated domain; Region: CorC_HlyC; smart01091
349124001899	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
349124001900	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
349124001901	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
349124001902	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
349124001903	active site
349124001904	putative substrate binding pocket [chemical binding]; other site
349124001905	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
349124001906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124001907	S-adenosylmethionine binding site [chemical binding]; other site
349124001908	phosphoglycolate phosphatase; Provisional; Region: PRK13222
349124001909	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349124001910	motif II; other site
349124001911	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
349124001912	substrate binding pocket [chemical binding]; other site
349124001913	substrate-Mg2+ binding site; other site
349124001914	aspartate-rich region 2; other site
349124001915	HD domain; Region: HD_4; pfam13328
349124001916	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
349124001917	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349124001918	NAD(P) binding site [chemical binding]; other site
349124001919	active site
349124001920	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349124001921	endonuclease III; Region: ENDO3c; smart00478
349124001922	minor groove reading motif; other site
349124001923	helix-hairpin-helix signature motif; other site
349124001924	active site
349124001925	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
349124001926	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349124001927	RNA binding surface [nucleotide binding]; other site
349124001928	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
349124001929	probable active site [active]
349124001930	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
349124001931	ScpA/B protein; Region: ScpA_ScpB; cl00598
349124001932	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
349124001933	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
349124001934	active site
349124001935	HIGH motif; other site
349124001936	dimer interface [polypeptide binding]; other site
349124001937	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349124001938	active site
349124001939	KMSKS motif; other site
349124001940	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
349124001941	YciI-like protein; Reviewed; Region: PRK11370
349124001942	TspO/MBR family; Region: TspO_MBR; pfam03073
349124001943	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
349124001944	Predicted permeases [General function prediction only]; Region: COG0701
349124001945	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
349124001946	active site
349124001947	GTP-binding protein Der; Reviewed; Region: PRK00093
349124001948	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
349124001949	G1 box; other site
349124001950	GTP/Mg2+ binding site [chemical binding]; other site
349124001951	Switch I region; other site
349124001952	G2 box; other site
349124001953	Switch II region; other site
349124001954	G3 box; other site
349124001955	G4 box; other site
349124001956	G5 box; other site
349124001957	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
349124001958	G1 box; other site
349124001959	GTP/Mg2+ binding site [chemical binding]; other site
349124001960	Switch I region; other site
349124001961	G2 box; other site
349124001962	G3 box; other site
349124001963	Switch II region; other site
349124001964	G4 box; other site
349124001965	G5 box; other site
349124001966	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
349124001967	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349124001968	Walker A/P-loop; other site
349124001969	ATP binding site [chemical binding]; other site
349124001970	Q-loop/lid; other site
349124001971	ABC transporter signature motif; other site
349124001972	Walker B; other site
349124001973	D-loop; other site
349124001974	H-loop/switch region; other site
349124001975	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349124001976	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349124001977	Walker A/P-loop; other site
349124001978	ATP binding site [chemical binding]; other site
349124001979	Q-loop/lid; other site
349124001980	ABC transporter signature motif; other site
349124001981	Walker B; other site
349124001982	D-loop; other site
349124001983	H-loop/switch region; other site
349124001984	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
349124001985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124001986	ABC-ATPase subunit interface; other site
349124001987	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
349124001988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124001989	dimer interface [polypeptide binding]; other site
349124001990	conserved gate region; other site
349124001991	putative PBP binding loops; other site
349124001992	ABC-ATPase subunit interface; other site
349124001993	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
349124001994	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
349124001995	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
349124001996	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
349124001997	NAD binding site [chemical binding]; other site
349124001998	homotetramer interface [polypeptide binding]; other site
349124001999	homodimer interface [polypeptide binding]; other site
349124002000	substrate binding site [chemical binding]; other site
349124002001	active site
349124002002	SurA N-terminal domain; Region: SurA_N_3; cl07813
349124002003	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349124002004	IHF dimer interface [polypeptide binding]; other site
349124002005	IHF - DNA interface [nucleotide binding]; other site
349124002006	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
349124002007	Found in ATP-dependent protease La (LON); Region: LON; smart00464
349124002008	Found in ATP-dependent protease La (LON); Region: LON; smart00464
349124002009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124002010	Walker A motif; other site
349124002011	ATP binding site [chemical binding]; other site
349124002012	Walker B motif; other site
349124002013	arginine finger; other site
349124002014	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
349124002015	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
349124002016	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
349124002017	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124002018	Walker A motif; other site
349124002019	ATP binding site [chemical binding]; other site
349124002020	Walker B motif; other site
349124002021	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349124002022	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
349124002023	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
349124002024	oligomer interface [polypeptide binding]; other site
349124002025	active site residues [active]
349124002026	trigger factor; Provisional; Region: tig; PRK01490
349124002027	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
349124002028	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
349124002029	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
349124002030	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
349124002031	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
349124002032	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
349124002033	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349124002034	PilZ domain; Region: PilZ; pfam07238
349124002035	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
349124002036	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
349124002037	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
349124002038	homodimer interface [polypeptide binding]; other site
349124002039	NADP binding site [chemical binding]; other site
349124002040	substrate binding site [chemical binding]; other site
349124002041	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
349124002042	Integrase core domain; Region: rve; pfam00665
349124002043	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
349124002044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124002045	Walker A motif; other site
349124002046	ATP binding site [chemical binding]; other site
349124002047	Walker B motif; other site
349124002048	HTH-like domain; Region: HTH_21; pfam13276
349124002049	Integrase core domain; Region: rve; pfam00665
349124002050	HTH-like domain; Region: HTH_21; pfam13276
349124002051	Integrase core domain; Region: rve; pfam00665
349124002052	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
349124002053	Transposase; Region: HTH_Tnp_1; cl17663
349124002054	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349124002055	non-specific DNA binding site [nucleotide binding]; other site
349124002056	salt bridge; other site
349124002057	sequence-specific DNA binding site [nucleotide binding]; other site
349124002058	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
349124002059	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
349124002060	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
349124002061	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
349124002062	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
349124002063	CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cd09743
349124002064	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741
349124002065	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
349124002066	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
349124002067	CRISPR-associated protein; Region: DUF3692; pfam12469
349124002068	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
349124002069	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
349124002070	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748
349124002071	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
349124002072	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749
349124002073	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
349124002074	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
349124002075	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
349124002076	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
349124002077	CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cd09743
349124002078	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
349124002079	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124002080	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
349124002081	Walker A motif; other site
349124002082	ATP binding site [chemical binding]; other site
349124002083	Walker B motif; other site
349124002084	arginine finger; other site
349124002085	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
349124002086	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
349124002087	ParB-like nuclease domain; Region: ParBc; pfam02195
349124002088	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349124002089	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349124002090	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349124002091	Magnesium ion binding site [ion binding]; other site
349124002092	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
349124002093	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349124002094	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349124002095	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349124002096	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349124002097	dimerization interface [polypeptide binding]; other site
349124002098	putative DNA binding site [nucleotide binding]; other site
349124002099	putative Zn2+ binding site [ion binding]; other site
349124002100	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349124002101	active site residue [active]
349124002102	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124002103	dimer interface [polypeptide binding]; other site
349124002104	phosphorylation site [posttranslational modification]
349124002105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124002106	ATP binding site [chemical binding]; other site
349124002107	Mg2+ binding site [ion binding]; other site
349124002108	G-X-G motif; other site
349124002109	Response regulator receiver domain; Region: Response_reg; pfam00072
349124002110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124002111	active site
349124002112	phosphorylation site [posttranslational modification]
349124002113	intermolecular recognition site; other site
349124002114	dimerization interface [polypeptide binding]; other site
349124002115	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349124002116	putative binding surface; other site
349124002117	active site
349124002118	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
349124002119	DNA repair protein RadA; Provisional; Region: PRK11823
349124002120	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349124002121	Walker A motif; other site
349124002122	ATP binding site [chemical binding]; other site
349124002123	Walker B motif; other site
349124002124	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
349124002125	alanine racemase; Reviewed; Region: alr; PRK00053
349124002126	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
349124002127	active site
349124002128	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349124002129	substrate binding site [chemical binding]; other site
349124002130	catalytic residues [active]
349124002131	dimer interface [polypeptide binding]; other site
349124002132	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
349124002133	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349124002134	Walker A motif; other site
349124002135	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
349124002136	protein-splicing catalytic site; other site
349124002137	thioester formation/cholesterol transfer; other site
349124002138	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
349124002139	protein-splicing catalytic site; other site
349124002140	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
349124002141	Walker B motif; other site
349124002142	DNA binding loops [nucleotide binding]
349124002143	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
349124002144	protein-splicing catalytic site; other site
349124002145	thioester formation/cholesterol transfer; other site
349124002146	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349124002147	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
349124002148	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
349124002149	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
349124002150	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
349124002151	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
349124002152	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
349124002153	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
349124002154	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
349124002155	ribonuclease R; Region: RNase_R; TIGR02063
349124002156	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
349124002157	RNB domain; Region: RNB; pfam00773
349124002158	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
349124002159	RNA binding site [nucleotide binding]; other site
349124002160	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
349124002161	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
349124002162	GDP-binding site [chemical binding]; other site
349124002163	ACT binding site; other site
349124002164	IMP binding site; other site
349124002165	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
349124002166	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
349124002167	dimer interface [polypeptide binding]; other site
349124002168	motif 1; other site
349124002169	active site
349124002170	motif 2; other site
349124002171	motif 3; other site
349124002172	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
349124002173	FtsH protease regulator HflC; Provisional; Region: PRK11029
349124002174	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
349124002175	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
349124002176	HflK protein; Region: hflK; TIGR01933
349124002177	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
349124002178	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
349124002179	HflX GTPase family; Region: HflX; cd01878
349124002180	G1 box; other site
349124002181	GTP/Mg2+ binding site [chemical binding]; other site
349124002182	Switch I region; other site
349124002183	G2 box; other site
349124002184	G3 box; other site
349124002185	Switch II region; other site
349124002186	G4 box; other site
349124002187	G5 box; other site
349124002188	bacterial Hfq-like; Region: Hfq; cd01716
349124002189	hexamer interface [polypeptide binding]; other site
349124002190	Sm1 motif; other site
349124002191	RNA binding site [nucleotide binding]; other site
349124002192	Sm2 motif; other site
349124002193	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
349124002194	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
349124002195	active site
349124002196	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
349124002197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124002198	ATP binding site [chemical binding]; other site
349124002199	Mg2+ binding site [ion binding]; other site
349124002200	G-X-G motif; other site
349124002201	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
349124002202	ATP binding site [chemical binding]; other site
349124002203	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
349124002204	AMIN domain; Region: AMIN; pfam11741
349124002205	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
349124002206	active site
349124002207	metal binding site [ion binding]; metal-binding site
349124002208	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349124002209	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
349124002210	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
349124002211	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
349124002212	putative substrate binding site [chemical binding]; other site
349124002213	putative ATP binding site [chemical binding]; other site
349124002214	epoxyqueuosine reductase; Region: TIGR00276
349124002215	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
349124002216	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
349124002217	tetramerization interface [polypeptide binding]; other site
349124002218	active site
349124002219	Pantoate-beta-alanine ligase; Region: PanC; cd00560
349124002220	pantoate--beta-alanine ligase; Region: panC; TIGR00018
349124002221	active site
349124002222	ATP-binding site [chemical binding]; other site
349124002223	pantoate-binding site; other site
349124002224	HXXH motif; other site
349124002225	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
349124002226	oligomerization interface [polypeptide binding]; other site
349124002227	active site
349124002228	metal binding site [ion binding]; metal-binding site
349124002229	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
349124002230	catalytic center binding site [active]
349124002231	ATP binding site [chemical binding]; other site
349124002232	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
349124002233	active site
349124002234	NTP binding site [chemical binding]; other site
349124002235	metal binding triad [ion binding]; metal-binding site
349124002236	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
349124002237	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
349124002238	RDD family; Region: RDD; pfam06271
349124002239	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
349124002240	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
349124002241	Predicted permeases [General function prediction only]; Region: COG0795
349124002242	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
349124002243	multifunctional aminopeptidase A; Provisional; Region: PRK00913
349124002244	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
349124002245	interface (dimer of trimers) [polypeptide binding]; other site
349124002246	Substrate-binding/catalytic site; other site
349124002247	Zn-binding sites [ion binding]; other site
349124002248	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
349124002249	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
349124002250	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
349124002251	HIGH motif; other site
349124002252	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
349124002253	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
349124002254	active site
349124002255	KMSKS motif; other site
349124002256	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
349124002257	tRNA binding surface [nucleotide binding]; other site
349124002258	anticodon binding site; other site
349124002259	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
349124002260	Uncharacterized conserved protein [Function unknown]; Region: COG2361
349124002261	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
349124002262	active site
349124002263	NTP binding site [chemical binding]; other site
349124002264	metal binding triad [ion binding]; metal-binding site
349124002265	antibiotic binding site [chemical binding]; other site
349124002266	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
349124002267	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349124002268	Coenzyme A binding pocket [chemical binding]; other site
349124002269	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
349124002270	Fe-S cluster binding site [ion binding]; other site
349124002271	active site
349124002272	2-isopropylmalate synthase; Validated; Region: PRK00915
349124002273	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
349124002274	active site
349124002275	catalytic residues [active]
349124002276	metal binding site [ion binding]; metal-binding site
349124002277	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
349124002278	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
349124002279	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
349124002280	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349124002281	active site residue [active]
349124002282	ketol-acid reductoisomerase; Provisional; Region: PRK05479
349124002283	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
349124002284	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
349124002285	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
349124002286	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
349124002287	putative valine binding site [chemical binding]; other site
349124002288	dimer interface [polypeptide binding]; other site
349124002289	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
349124002290	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349124002291	non-specific DNA binding site [nucleotide binding]; other site
349124002292	salt bridge; other site
349124002293	sequence-specific DNA binding site [nucleotide binding]; other site
349124002294	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124002295	putative active site [active]
349124002296	heme pocket [chemical binding]; other site
349124002297	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124002298	metal binding site [ion binding]; metal-binding site
349124002299	active site
349124002300	I-site; other site
349124002301	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124002302	prolyl-tRNA synthetase; Provisional; Region: PRK09194
349124002303	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
349124002304	dimer interface [polypeptide binding]; other site
349124002305	motif 1; other site
349124002306	active site
349124002307	motif 2; other site
349124002308	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
349124002309	putative deacylase active site [active]
349124002310	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349124002311	active site
349124002312	motif 3; other site
349124002313	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
349124002314	anticodon binding site; other site
349124002315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349124002316	NADH(P)-binding; Region: NAD_binding_10; pfam13460
349124002317	NAD(P) binding site [chemical binding]; other site
349124002318	active site
349124002319	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
349124002320	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
349124002321	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
349124002322	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
349124002323	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
349124002324	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
349124002325	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
349124002326	Protein of unknown function, DUF481; Region: DUF481; pfam04338
349124002327	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
349124002328	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
349124002329	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
349124002330	dimerization interface [polypeptide binding]; other site
349124002331	putative ATP binding site [chemical binding]; other site
349124002332	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
349124002333	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
349124002334	active site
349124002335	substrate binding site [chemical binding]; other site
349124002336	cosubstrate binding site; other site
349124002337	catalytic site [active]
349124002338	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
349124002339	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
349124002340	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
349124002341	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
349124002342	trimer interface [polypeptide binding]; other site
349124002343	active site
349124002344	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
349124002345	MgtE intracellular N domain; Region: MgtE_N; pfam03448
349124002346	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
349124002347	Divalent cation transporter; Region: MgtE; pfam01769
349124002348	Bacitracin resistance protein BacA; Region: BacA; pfam02673
349124002349	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
349124002350	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
349124002351	active site
349124002352	HIGH motif; other site
349124002353	KMSKS motif; other site
349124002354	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
349124002355	anticodon binding site; other site
349124002356	tRNA binding surface [nucleotide binding]; other site
349124002357	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
349124002358	putative tRNA-binding site [nucleotide binding]; other site
349124002359	dimer interface [polypeptide binding]; other site
349124002360	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
349124002361	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349124002362	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349124002363	protein binding site [polypeptide binding]; other site
349124002364	electron transport complex protein RsxA; Provisional; Region: PRK05151
349124002365	Bifunctional nuclease; Region: DNase-RNase; pfam02577
349124002366	electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944
349124002367	Putative Fe-S cluster; Region: FeS; cl17515
349124002368	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
349124002369	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
349124002370	SLBB domain; Region: SLBB; pfam10531
349124002371	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349124002372	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
349124002373	electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947
349124002374	electron transport complex RsxE subunit; Provisional; Region: PRK12405
349124002375	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349124002376	endonuclease III; Region: ENDO3c; smart00478
349124002377	minor groove reading motif; other site
349124002378	helix-hairpin-helix signature motif; other site
349124002379	substrate binding pocket [chemical binding]; other site
349124002380	active site
349124002381	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
349124002382	argininosuccinate synthase; Provisional; Region: PRK13820
349124002383	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
349124002384	ANP binding site [chemical binding]; other site
349124002385	Substrate Binding Site II [chemical binding]; other site
349124002386	Substrate Binding Site I [chemical binding]; other site
349124002387	ornithine carbamoyltransferase; Provisional; Region: PRK00779
349124002388	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
349124002389	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
349124002390	acetylornithine aminotransferase; Provisional; Region: PRK02627
349124002391	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349124002392	inhibitor-cofactor binding pocket; inhibition site
349124002393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124002394	catalytic residue [active]
349124002395	ribonuclease T; Provisional; Region: PRK05168
349124002396	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
349124002397	active site
349124002398	catalytic site [active]
349124002399	substrate binding site [chemical binding]; other site
349124002400	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
349124002401	putative GSH binding site [chemical binding]; other site
349124002402	catalytic residues [active]
349124002403	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
349124002404	active site
349124002405	substrate binding pocket [chemical binding]; other site
349124002406	dimer interface [polypeptide binding]; other site
349124002407	Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097
349124002408	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349124002409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124002410	Walker A motif; other site
349124002411	ATP binding site [chemical binding]; other site
349124002412	Walker B motif; other site
349124002413	arginine finger; other site
349124002414	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
349124002415	5-oxoprolinase; Region: PLN02666
349124002416	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
349124002417	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
349124002418	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
349124002419	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
349124002420	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
349124002421	putative active site [active]
349124002422	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
349124002423	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
349124002424	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
349124002425	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
349124002426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
349124002427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
349124002428	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
349124002429	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
349124002430	active site
349124002431	NTP binding site [chemical binding]; other site
349124002432	metal binding triad [ion binding]; metal-binding site
349124002433	antibiotic binding site [chemical binding]; other site
349124002434	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
349124002435	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
349124002436	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349124002437	active site
349124002438	DNA binding site [nucleotide binding]
349124002439	Int/Topo IB signature motif; other site
349124002440	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
349124002441	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
349124002442	oligomeric interface; other site
349124002443	putative active site [active]
349124002444	homodimer interface [polypeptide binding]; other site
349124002445	Probable transposase; Region: OrfB_IS605; pfam01385
349124002446	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
349124002447	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
349124002448	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
349124002449	active site
349124002450	NTP binding site [chemical binding]; other site
349124002451	metal binding triad [ion binding]; metal-binding site
349124002452	antibiotic binding site [chemical binding]; other site
349124002453	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
349124002454	active site
349124002455	NTP binding site [chemical binding]; other site
349124002456	metal binding triad [ion binding]; metal-binding site
349124002457	antibiotic binding site [chemical binding]; other site
349124002458	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
349124002459	EPS-associated transcriptional regulator, MarR family; Region: MarR_EPS; TIGR04176
349124002460	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
349124002461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124002462	Walker A/P-loop; other site
349124002463	ATP binding site [chemical binding]; other site
349124002464	Q-loop/lid; other site
349124002465	ABC transporter signature motif; other site
349124002466	Walker B; other site
349124002467	D-loop; other site
349124002468	H-loop/switch region; other site
349124002469	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
349124002470	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
349124002471	hinge; other site
349124002472	active site
349124002473	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
349124002474	FAD binding domain; Region: FAD_binding_4; pfam01565
349124002475	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
349124002476	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
349124002477	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
349124002478	active site
349124002479	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
349124002480	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
349124002481	putative transposase OrfB; Reviewed; Region: PHA02517
349124002482	HTH-like domain; Region: HTH_21; pfam13276
349124002483	Integrase core domain; Region: rve; pfam00665
349124002484	Integrase core domain; Region: rve_3; pfam13683
349124002485	Integrase core domain; Region: rve_3; cl15866
349124002486	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
349124002487	Transposase; Region: DEDD_Tnp_IS110; pfam01548
349124002488	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
349124002489	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
349124002490	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
349124002491	NAD binding site [chemical binding]; other site
349124002492	homodimer interface [polypeptide binding]; other site
349124002493	active site
349124002494	substrate binding site [chemical binding]; other site
349124002495	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349124002496	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349124002497	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349124002498	active site
349124002499	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
349124002500	hypothetical protein; Provisional; Region: PRK05849
349124002501	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349124002502	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
349124002503	catalytic triad [active]
349124002504	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
349124002505	active site
349124002506	metal-binding site
349124002507	LicD family; Region: LicD; pfam04991
349124002508	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349124002509	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349124002510	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
349124002511	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349124002512	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
349124002513	putative ADP-binding pocket [chemical binding]; other site
349124002514	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349124002515	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
349124002516	putative ADP-binding pocket [chemical binding]; other site
349124002517	translocation protein TolB; Provisional; Region: tolB; PRK05137
349124002518	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
349124002519	GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195
349124002520	Transposase [DNA replication, recombination, and repair]; Region: COG5421
349124002521	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
349124002522	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
349124002523	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
349124002524	putative active site [active]
349124002525	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
349124002526	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
349124002527	oligomeric interface; other site
349124002528	putative active site [active]
349124002529	homodimer interface [polypeptide binding]; other site
349124002530	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
349124002531	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
349124002532	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
349124002533	oligomeric interface; other site
349124002534	homodimer interface [polypeptide binding]; other site
349124002535	putative active site [active]
349124002536	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
349124002537	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349124002538	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
349124002539	active site
349124002540	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
349124002541	Kae1-associated kinase Bud32; Region: arch_bud32; TIGR03724
349124002542	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
349124002543	active site
349124002544	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
349124002545	active site
349124002546	ATP binding site [chemical binding]; other site
349124002547	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
349124002548	active site
349124002549	ATP binding site [chemical binding]; other site
349124002550	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
349124002551	active site
349124002552	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
349124002553	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
349124002554	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349124002555	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
349124002556	Walker A/P-loop; other site
349124002557	ATP binding site [chemical binding]; other site
349124002558	Q-loop/lid; other site
349124002559	ABC transporter signature motif; other site
349124002560	Walker B; other site
349124002561	D-loop; other site
349124002562	H-loop/switch region; other site
349124002563	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
349124002564	Mg++ binding site [ion binding]; other site
349124002565	putative catalytic motif [active]
349124002566	substrate binding site [chemical binding]; other site
349124002567	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
349124002568	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
349124002569	Walker A/P-loop; other site
349124002570	ATP binding site [chemical binding]; other site
349124002571	Q-loop/lid; other site
349124002572	ABC transporter signature motif; other site
349124002573	Walker B; other site
349124002574	D-loop; other site
349124002575	H-loop/switch region; other site
349124002576	TOBE domain; Region: TOBE_2; pfam08402
349124002577	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
349124002578	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009
349124002579	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
349124002580	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349124002581	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
349124002582	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349124002583	Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006
349124002584	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
349124002585	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
349124002586	ferrochelatase; Reviewed; Region: hemH; PRK00035
349124002587	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
349124002588	C-terminal domain interface [polypeptide binding]; other site
349124002589	active site
349124002590	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
349124002591	active site
349124002592	N-terminal domain interface [polypeptide binding]; other site
349124002593	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
349124002594	Low molecular weight phosphatase family; Region: LMWPc; cl00105
349124002595	active site
349124002596	Peptidase family M48; Region: Peptidase_M48; pfam01435
349124002597	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124002598	binding surface
349124002599	TPR motif; other site
349124002600	HemK family putative methylases; Region: hemK_fam; TIGR00536
349124002601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124002602	S-adenosylmethionine binding site [chemical binding]; other site
349124002603	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
349124002604	Cu(I) binding site [ion binding]; other site
349124002605	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
349124002606	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
349124002607	active site
349124002608	NTP binding site [chemical binding]; other site
349124002609	metal binding triad [ion binding]; metal-binding site
349124002610	antibiotic binding site [chemical binding]; other site
349124002611	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349124002612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124002613	S-adenosylmethionine binding site [chemical binding]; other site
349124002614	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
349124002615	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349124002616	inhibitor-cofactor binding pocket; inhibition site
349124002617	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124002618	catalytic residue [active]
349124002619	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
349124002620	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349124002621	Beta-Casp domain; Region: Beta-Casp; smart01027
349124002622	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
349124002623	tartrate dehydrogenase; Region: TTC; TIGR02089
349124002624	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
349124002625	malate dehydrogenase; Provisional; Region: PRK05442
349124002626	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
349124002627	NAD(P) binding site [chemical binding]; other site
349124002628	dimer interface [polypeptide binding]; other site
349124002629	malate binding site [chemical binding]; other site
349124002630	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
349124002631	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
349124002632	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
349124002633	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
349124002634	alphaNTD homodimer interface [polypeptide binding]; other site
349124002635	alphaNTD - beta interaction site [polypeptide binding]; other site
349124002636	alphaNTD - beta' interaction site [polypeptide binding]; other site
349124002637	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
349124002638	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
349124002639	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
349124002640	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349124002641	RNA binding surface [nucleotide binding]; other site
349124002642	30S ribosomal protein S11; Validated; Region: PRK05309
349124002643	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
349124002644	30S ribosomal protein S13; Region: bact_S13; TIGR03631
349124002645	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
349124002646	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
349124002647	SecY translocase; Region: SecY; pfam00344
349124002648	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
349124002649	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
349124002650	23S rRNA binding site [nucleotide binding]; other site
349124002651	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
349124002652	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
349124002653	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
349124002654	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
349124002655	5S rRNA interface [nucleotide binding]; other site
349124002656	23S rRNA interface [nucleotide binding]; other site
349124002657	L5 interface [polypeptide binding]; other site
349124002658	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
349124002659	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
349124002660	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
349124002661	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
349124002662	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
349124002663	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
349124002664	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
349124002665	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
349124002666	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
349124002667	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
349124002668	RNA binding site [nucleotide binding]; other site
349124002669	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
349124002670	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
349124002671	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
349124002672	L23 interface [polypeptide binding]; other site
349124002673	signal recognition particle (SRP54) interaction site; other site
349124002674	trigger factor interaction site; other site
349124002675	23S rRNA interface [nucleotide binding]; other site
349124002676	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
349124002677	23S rRNA interface [nucleotide binding]; other site
349124002678	5S rRNA interface [nucleotide binding]; other site
349124002679	putative antibiotic binding site [chemical binding]; other site
349124002680	L25 interface [polypeptide binding]; other site
349124002681	L27 interface [polypeptide binding]; other site
349124002682	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
349124002683	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
349124002684	G-X-X-G motif; other site
349124002685	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
349124002686	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
349124002687	putative translocon binding site; other site
349124002688	protein-rRNA interface [nucleotide binding]; other site
349124002689	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
349124002690	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
349124002691	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
349124002692	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
349124002693	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
349124002694	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
349124002695	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
349124002696	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
349124002697	elongation factor Tu; Reviewed; Region: PRK00049
349124002698	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
349124002699	G1 box; other site
349124002700	GEF interaction site [polypeptide binding]; other site
349124002701	GTP/Mg2+ binding site [chemical binding]; other site
349124002702	Switch I region; other site
349124002703	G2 box; other site
349124002704	G3 box; other site
349124002705	Switch II region; other site
349124002706	G4 box; other site
349124002707	G5 box; other site
349124002708	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
349124002709	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
349124002710	Antibiotic Binding Site [chemical binding]; other site
349124002711	elongation factor G; Reviewed; Region: PRK00007
349124002712	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
349124002713	G1 box; other site
349124002714	putative GEF interaction site [polypeptide binding]; other site
349124002715	GTP/Mg2+ binding site [chemical binding]; other site
349124002716	Switch I region; other site
349124002717	G2 box; other site
349124002718	G3 box; other site
349124002719	Switch II region; other site
349124002720	G4 box; other site
349124002721	G5 box; other site
349124002722	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
349124002723	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
349124002724	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
349124002725	30S ribosomal protein S7; Validated; Region: PRK05302
349124002726	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
349124002727	S17 interaction site [polypeptide binding]; other site
349124002728	S8 interaction site; other site
349124002729	16S rRNA interaction site [nucleotide binding]; other site
349124002730	streptomycin interaction site [chemical binding]; other site
349124002731	23S rRNA interaction site [nucleotide binding]; other site
349124002732	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
349124002733	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
349124002734	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
349124002735	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
349124002736	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
349124002737	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
349124002738	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
349124002739	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
349124002740	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
349124002741	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
349124002742	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
349124002743	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
349124002744	DNA binding site [nucleotide binding]
349124002745	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
349124002746	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
349124002747	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
349124002748	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
349124002749	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
349124002750	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
349124002751	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
349124002752	RPB3 interaction site [polypeptide binding]; other site
349124002753	RPB1 interaction site [polypeptide binding]; other site
349124002754	RPB11 interaction site [polypeptide binding]; other site
349124002755	RPB10 interaction site [polypeptide binding]; other site
349124002756	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
349124002757	core dimer interface [polypeptide binding]; other site
349124002758	peripheral dimer interface [polypeptide binding]; other site
349124002759	L10 interface [polypeptide binding]; other site
349124002760	L11 interface [polypeptide binding]; other site
349124002761	putative EF-Tu interaction site [polypeptide binding]; other site
349124002762	putative EF-G interaction site [polypeptide binding]; other site
349124002763	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
349124002764	23S rRNA interface [nucleotide binding]; other site
349124002765	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
349124002766	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
349124002767	mRNA/rRNA interface [nucleotide binding]; other site
349124002768	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
349124002769	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
349124002770	23S rRNA interface [nucleotide binding]; other site
349124002771	L7/L12 interface [polypeptide binding]; other site
349124002772	putative thiostrepton binding site; other site
349124002773	L25 interface [polypeptide binding]; other site
349124002774	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
349124002775	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
349124002776	putative homodimer interface [polypeptide binding]; other site
349124002777	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
349124002778	heterodimer interface [polypeptide binding]; other site
349124002779	homodimer interface [polypeptide binding]; other site
349124002780	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
349124002781	elongation factor Tu; Reviewed; Region: PRK00049
349124002782	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
349124002783	G1 box; other site
349124002784	GEF interaction site [polypeptide binding]; other site
349124002785	GTP/Mg2+ binding site [chemical binding]; other site
349124002786	Switch I region; other site
349124002787	G2 box; other site
349124002788	G3 box; other site
349124002789	Switch II region; other site
349124002790	G4 box; other site
349124002791	G5 box; other site
349124002792	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
349124002793	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
349124002794	Antibiotic Binding Site [chemical binding]; other site
349124002795	pantothenate kinase; Reviewed; Region: PRK13322
349124002796	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
349124002797	Biotin operon repressor [Transcription]; Region: BirA; COG1654
349124002798	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
349124002799	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
349124002800	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
349124002801	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
349124002802	active site
349124002803	HIGH motif; other site
349124002804	dimer interface [polypeptide binding]; other site
349124002805	KMSKS motif; other site
349124002806	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349124002807	RNA binding surface [nucleotide binding]; other site
349124002808	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
349124002809	Peptidase family M23; Region: Peptidase_M23; pfam01551
349124002810	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
349124002811	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
349124002812	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
349124002813	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
349124002814	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
349124002815	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
349124002816	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
349124002817	heme binding site [chemical binding]; other site
349124002818	ferroxidase pore; other site
349124002819	ferroxidase diiron center [ion binding]; other site
349124002820	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
349124002821	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
349124002822	GAF domain; Region: GAF; pfam01590
349124002823	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
349124002824	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
349124002825	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
349124002826	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
349124002827	putative active site [active]
349124002828	Ap4A binding site [chemical binding]; other site
349124002829	nudix motif; other site
349124002830	putative metal binding site [ion binding]; other site
349124002831	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
349124002832	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
349124002833	LrgA family; Region: LrgA; pfam03788
349124002834	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
349124002835	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
349124002836	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
349124002837	putative active site [active]
349124002838	catalytic triad [active]
349124002839	putative dimer interface [polypeptide binding]; other site
349124002840	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
349124002841	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
349124002842	Transporter associated domain; Region: CorC_HlyC; smart01091
349124002843	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
349124002844	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
349124002845	PhoH-like protein; Region: PhoH; pfam02562
349124002846	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
349124002847	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
349124002848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124002849	FeS/SAM binding site; other site
349124002850	TRAM domain; Region: TRAM; pfam01938
349124002851	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
349124002852	tetramer interfaces [polypeptide binding]; other site
349124002853	binuclear metal-binding site [ion binding]; other site
349124002854	thiamine monophosphate kinase; Provisional; Region: PRK05731
349124002855	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
349124002856	ATP binding site [chemical binding]; other site
349124002857	dimerization interface [polypeptide binding]; other site
349124002858	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
349124002859	putative RNA binding site [nucleotide binding]; other site
349124002860	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
349124002861	homopentamer interface [polypeptide binding]; other site
349124002862	active site
349124002863	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
349124002864	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
349124002865	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
349124002866	dimerization interface [polypeptide binding]; other site
349124002867	active site
349124002868	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
349124002869	Lumazine binding domain; Region: Lum_binding; pfam00677
349124002870	Lumazine binding domain; Region: Lum_binding; pfam00677
349124002871	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
349124002872	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
349124002873	catalytic motif [active]
349124002874	Zn binding site [ion binding]; other site
349124002875	RibD C-terminal domain; Region: RibD_C; cl17279
349124002876	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
349124002877	ATP cone domain; Region: ATP-cone; pfam03477
349124002878	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
349124002879	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
349124002880	dimer interface [polypeptide binding]; other site
349124002881	active site
349124002882	glycine-pyridoxal phosphate binding site [chemical binding]; other site
349124002883	folate binding site [chemical binding]; other site
349124002884	Haemolysin-III related; Region: HlyIII; cl03831
349124002885	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
349124002886	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
349124002887	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
349124002888	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
349124002889	dimer interface [polypeptide binding]; other site
349124002890	active site
349124002891	metal binding site [ion binding]; metal-binding site
349124002892	glutathione binding site [chemical binding]; other site
349124002893	hypothetical protein; Provisional; Region: PRK07907
349124002894	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
349124002895	metal binding site [ion binding]; metal-binding site
349124002896	putative dimer interface [polypeptide binding]; other site
349124002897	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
349124002898	putative ADP-ribose binding site [chemical binding]; other site
349124002899	putative active site [active]
349124002900	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
349124002901	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
349124002902	putative metal binding site [ion binding]; other site
349124002903	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349124002904	HSP70 interaction site [polypeptide binding]; other site
349124002905	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349124002906	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
349124002907	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
349124002908	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
349124002909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124002910	S-adenosylmethionine binding site [chemical binding]; other site
349124002911	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
349124002912	DNA binding residues [nucleotide binding]
349124002913	B12 binding domain; Region: B12-binding_2; pfam02607
349124002914	DNA photolyase; Region: DNA_photolyase; pfam00875
349124002915	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
349124002916	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
349124002917	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
349124002918	ATP binding site [chemical binding]; other site
349124002919	active site
349124002920	substrate binding site [chemical binding]; other site
349124002921	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349124002922	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349124002923	ligand binding site [chemical binding]; other site
349124002924	flexible hinge region; other site
349124002925	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
349124002926	putative switch regulator; other site
349124002927	non-specific DNA interactions [nucleotide binding]; other site
349124002928	DNA binding site [nucleotide binding]
349124002929	sequence specific DNA binding site [nucleotide binding]; other site
349124002930	putative cAMP binding site [chemical binding]; other site
349124002931	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
349124002932	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
349124002933	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
349124002934	S-adenosylmethionine synthetase; Validated; Region: PRK05250
349124002935	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
349124002936	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
349124002937	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
349124002938	C factor cell-cell signaling protein; Provisional; Region: PRK09009
349124002939	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
349124002940	NADP binding site [chemical binding]; other site
349124002941	homodimer interface [polypeptide binding]; other site
349124002942	active site
349124002943	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
349124002944	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349124002945	substrate binding site [chemical binding]; other site
349124002946	ATP binding site [chemical binding]; other site
349124002947	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
349124002948	active site
349124002949	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
349124002950	NADH(P)-binding; Region: NAD_binding_10; pfam13460
349124002951	NAD binding site [chemical binding]; other site
349124002952	substrate binding site [chemical binding]; other site
349124002953	putative active site [active]
349124002954	helicase 45; Provisional; Region: PTZ00424
349124002955	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
349124002956	ATP binding site [chemical binding]; other site
349124002957	Mg++ binding site [ion binding]; other site
349124002958	motif III; other site
349124002959	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349124002960	nucleotide binding region [chemical binding]; other site
349124002961	ATP-binding site [chemical binding]; other site
349124002962	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
349124002963	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
349124002964	metal binding site [ion binding]; metal-binding site
349124002965	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
349124002966	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
349124002967	nucleotide binding site [chemical binding]; other site
349124002968	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
349124002969	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
349124002970	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
349124002971	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030
349124002972	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349124002973	inhibitor-cofactor binding pocket; inhibition site
349124002974	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124002975	catalytic residue [active]
349124002976	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
349124002977	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349124002978	putative binding surface; other site
349124002979	active site
349124002980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124002981	ATP binding site [chemical binding]; other site
349124002982	Mg2+ binding site [ion binding]; other site
349124002983	G-X-G motif; other site
349124002984	glutathione synthetase; Provisional; Region: PRK05246
349124002985	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
349124002986	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
349124002987	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
349124002988	ApbE family; Region: ApbE; pfam02424
349124002989	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
349124002990	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
349124002991	hypothetical protein; Validated; Region: PRK00228
349124002992	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
349124002993	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
349124002994	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349124002995	active site
349124002996	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
349124002997	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
349124002998	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
349124002999	dihydroorotase; Provisional; Region: PRK07627
349124003000	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
349124003001	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
349124003002	active site
349124003003	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
349124003004	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
349124003005	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
349124003006	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349124003007	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349124003008	catalytic residue [active]
349124003009	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
349124003010	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349124003011	catalytic residue [active]
349124003012	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
349124003013	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
349124003014	YGGT family; Region: YGGT; pfam02325
349124003015	YGGT family; Region: YGGT; pfam02325
349124003016	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
349124003017	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
349124003018	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
349124003019	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349124003020	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124003021	S-adenosylmethionine binding site [chemical binding]; other site
349124003022	spermidine synthase; Provisional; Region: PRK00811
349124003023	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124003024	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
349124003025	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
349124003026	putative active site [active]
349124003027	Zn binding site [ion binding]; other site
349124003028	Predicted ATPase [General function prediction only]; Region: COG1485
349124003029	AAA ATPase domain; Region: AAA_16; pfam13191
349124003030	Walker A motif; other site
349124003031	ATP binding site [chemical binding]; other site
349124003032	Walker B motif; other site
349124003033	arginine finger; other site
349124003034	PilZ domain; Region: PilZ; pfam07238
349124003035	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
349124003036	substrate binding site [chemical binding]; other site
349124003037	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
349124003038	putative active site pocket [active]
349124003039	dimerization interface [polypeptide binding]; other site
349124003040	putative catalytic residue [active]
349124003041	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
349124003042	AAA domain; Region: AAA_26; pfam13500
349124003043	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
349124003044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124003045	S-adenosylmethionine binding site [chemical binding]; other site
349124003046	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
349124003047	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
349124003048	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
349124003049	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349124003050	catalytic residue [active]
349124003051	biotin synthase; Region: bioB; TIGR00433
349124003052	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124003053	FeS/SAM binding site; other site
349124003054	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
349124003055	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
349124003056	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
349124003057	UbiA prenyltransferase family; Region: UbiA; pfam01040
349124003058	Chorismate lyase; Region: Chor_lyase; cl01230
349124003059	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
349124003060	Y-family of DNA polymerases; Region: PolY; cl12025
349124003061	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
349124003062	ssDNA binding site; other site
349124003063	generic binding surface II; other site
349124003064	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349124003065	ATP binding site [chemical binding]; other site
349124003066	putative Mg++ binding site [ion binding]; other site
349124003067	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349124003068	nucleotide binding region [chemical binding]; other site
349124003069	ATP-binding site [chemical binding]; other site
349124003070	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
349124003071	homotrimer interaction site [polypeptide binding]; other site
349124003072	putative active site [active]
349124003073	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
349124003074	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349124003075	Zn2+ binding site [ion binding]; other site
349124003076	Mg2+ binding site [ion binding]; other site
349124003077	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
349124003078	synthetase active site [active]
349124003079	NTP binding site [chemical binding]; other site
349124003080	metal binding site [ion binding]; metal-binding site
349124003081	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
349124003082	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
349124003083	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
349124003084	HemN family oxidoreductase; Provisional; Region: PRK05660
349124003085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124003086	FeS/SAM binding site; other site
349124003087	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
349124003088	active site
349124003089	dimerization interface [polypeptide binding]; other site
349124003090	ribonuclease PH; Reviewed; Region: rph; PRK00173
349124003091	Ribonuclease PH; Region: RNase_PH_bact; cd11362
349124003092	hexamer interface [polypeptide binding]; other site
349124003093	active site
349124003094	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124003095	PAS domain; Region: PAS_9; pfam13426
349124003096	putative active site [active]
349124003097	heme pocket [chemical binding]; other site
349124003098	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124003099	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124003100	dimer interface [polypeptide binding]; other site
349124003101	putative CheW interface [polypeptide binding]; other site
349124003102	hypothetical protein; Provisional; Region: PRK11820
349124003103	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
349124003104	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
349124003105	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
349124003106	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
349124003107	catalytic site [active]
349124003108	G-X2-G-X-G-K; other site
349124003109	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
349124003110	metal binding site 2 [ion binding]; metal-binding site
349124003111	putative DNA binding helix; other site
349124003112	structural Zn2+ binding site [ion binding]; other site
349124003113	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
349124003114	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
349124003115	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
349124003116	putative active site [active]
349124003117	catalytic site [active]
349124003118	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
349124003119	putative active site [active]
349124003120	catalytic site [active]
349124003121	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
349124003122	FAD binding domain; Region: FAD_binding_4; pfam01565
349124003123	VacJ like lipoprotein; Region: VacJ; cl01073
349124003124	Adenylation domain of RNA circularization proteins; Region: Adenylation_RNA_ligase; cd07894
349124003125	active site
349124003126	dimer interface [polypeptide binding]; other site
349124003127	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
349124003128	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
349124003129	TPP-binding site; other site
349124003130	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
349124003131	PYR/PP interface [polypeptide binding]; other site
349124003132	dimer interface [polypeptide binding]; other site
349124003133	TPP binding site [chemical binding]; other site
349124003134	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349124003135	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349124003136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124003137	S-adenosylmethionine binding site [chemical binding]; other site
349124003138	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
349124003139	30S subunit binding site; other site
349124003140	GTP-binding protein YchF; Reviewed; Region: PRK09601
349124003141	YchF GTPase; Region: YchF; cd01900
349124003142	G1 box; other site
349124003143	GTP/Mg2+ binding site [chemical binding]; other site
349124003144	Switch I region; other site
349124003145	G2 box; other site
349124003146	Switch II region; other site
349124003147	G3 box; other site
349124003148	G4 box; other site
349124003149	G5 box; other site
349124003150	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
349124003151	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
349124003152	putative active site [active]
349124003153	catalytic residue [active]
349124003154	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
349124003155	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
349124003156	5S rRNA interface [nucleotide binding]; other site
349124003157	CTC domain interface [polypeptide binding]; other site
349124003158	L16 interface [polypeptide binding]; other site
349124003159	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
349124003160	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
349124003161	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349124003162	active site
349124003163	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
349124003164	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
349124003165	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
349124003166	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
349124003167	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124003168	TPR motif; other site
349124003169	binding surface
349124003170	TPR repeat; Region: TPR_11; pfam13414
349124003171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124003172	binding surface
349124003173	TPR repeat; Region: TPR_11; pfam13414
349124003174	TPR motif; other site
349124003175	TPR repeat; Region: TPR_11; pfam13414
349124003176	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
349124003177	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
349124003178	tRNA; other site
349124003179	putative tRNA binding site [nucleotide binding]; other site
349124003180	putative NADP binding site [chemical binding]; other site
349124003181	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
349124003182	peptide chain release factor 1; Validated; Region: prfA; PRK00591
349124003183	This domain is found in peptide chain release factors; Region: PCRF; smart00937
349124003184	RF-1 domain; Region: RF-1; pfam00472
349124003185	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
349124003186	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
349124003187	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
349124003188	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
349124003189	ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994
349124003190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124003191	Walker A motif; other site
349124003192	ATP binding site [chemical binding]; other site
349124003193	Walker B motif; other site
349124003194	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349124003195	Trm112p-like protein; Region: Trm112p; cl01066
349124003196	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
349124003197	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124003198	S-adenosylmethionine binding site [chemical binding]; other site
349124003199	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
349124003200	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
349124003201	ATP binding site [chemical binding]; other site
349124003202	substrate interface [chemical binding]; other site
349124003203	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
349124003204	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
349124003205	dimerization interface [polypeptide binding]; other site
349124003206	domain crossover interface; other site
349124003207	redox-dependent activation switch; other site
349124003208	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
349124003209	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
349124003210	GatB domain; Region: GatB_Yqey; smart00845
349124003211	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
349124003212	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
349124003213	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
349124003214	rod shape-determining protein MreB; Provisional; Region: PRK13927
349124003215	MreB and similar proteins; Region: MreB_like; cd10225
349124003216	nucleotide binding site [chemical binding]; other site
349124003217	Mg binding site [ion binding]; other site
349124003218	putative protofilament interaction site [polypeptide binding]; other site
349124003219	RodZ interaction site [polypeptide binding]; other site
349124003220	rod shape-determining protein MreC; Provisional; Region: PRK13922
349124003221	rod shape-determining protein MreC; Region: MreC; pfam04085
349124003222	rod shape-determining protein MreD; Region: MreD; cl01087
349124003223	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
349124003224	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
349124003225	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
349124003226	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
349124003227	Transglycosylase SLT domain; Region: SLT_2; pfam13406
349124003228	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349124003229	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349124003230	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
349124003231	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
349124003232	Sporulation related domain; Region: SPOR; pfam05036
349124003233	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
349124003234	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
349124003235	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
349124003236	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
349124003237	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
349124003238	homodimer interface [polypeptide binding]; other site
349124003239	substrate-cofactor binding pocket; other site
349124003240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124003241	catalytic residue [active]
349124003242	Protein of unknown function (DUF493); Region: DUF493; pfam04359
349124003243	lipoate-protein ligase B; Provisional; Region: PRK14342
349124003244	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256
349124003245	putative active site [active]
349124003246	Zn binding site [ion binding]; other site
349124003247	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
349124003248	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
349124003249	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
349124003250	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
349124003251	Substrate binding site; other site
349124003252	metal-binding site
349124003253	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
349124003254	Phosphotransferase enzyme family; Region: APH; pfam01636
349124003255	organic solvent tolerance protein; Provisional; Region: PRK04423
349124003256	Organic solvent tolerance protein; Region: OstA_C; pfam04453
349124003257	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
349124003258	SurA N-terminal domain; Region: SurA_N; pfam09312
349124003259	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
349124003260	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
349124003261	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
349124003262	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
349124003263	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
349124003264	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
349124003265	argininosuccinate lyase; Provisional; Region: PRK00855
349124003266	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
349124003267	active sites [active]
349124003268	tetramer interface [polypeptide binding]; other site
349124003269	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
349124003270	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
349124003271	domain interfaces; other site
349124003272	active site
349124003273	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
349124003274	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
349124003275	active site
349124003276	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
349124003277	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
349124003278	HemY protein N-terminus; Region: HemY_N; pfam07219
349124003279	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
349124003280	TPR motif; other site
349124003281	binding surface
349124003282	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
349124003283	Malic enzyme, N-terminal domain; Region: malic; pfam00390
349124003284	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
349124003285	putative NAD(P) binding site [chemical binding]; other site
349124003286	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
349124003287	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349124003288	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
349124003289	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
349124003290	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
349124003291	SCP-2 sterol transfer family; Region: SCP2; cl01225
349124003292	putative protease; Provisional; Region: PRK15447
349124003293	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
349124003294	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
349124003295	Peptidase family U32; Region: Peptidase_U32; pfam01136
349124003296	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349124003297	E3 interaction surface; other site
349124003298	lipoyl attachment site [posttranslational modification]; other site
349124003299	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
349124003300	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349124003301	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349124003302	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349124003303	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349124003304	E3 interaction surface; other site
349124003305	lipoyl attachment site [posttranslational modification]; other site
349124003306	e3 binding domain; Region: E3_binding; pfam02817
349124003307	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
349124003308	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
349124003309	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
349124003310	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
349124003311	dimer interface [polypeptide binding]; other site
349124003312	TPP-binding site [chemical binding]; other site
349124003313	Protein of unknown function (DUF502); Region: DUF502; cl01107
349124003314	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
349124003315	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
349124003316	intersubunit interface [polypeptide binding]; other site
349124003317	active site
349124003318	zinc binding site [ion binding]; other site
349124003319	Na+ binding site [ion binding]; other site
349124003320	pyruvate kinase; Provisional; Region: PRK05826
349124003321	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
349124003322	domain interfaces; other site
349124003323	active site
349124003324	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
349124003325	Phosphoglycerate kinase; Region: PGK; pfam00162
349124003326	substrate binding site [chemical binding]; other site
349124003327	hinge regions; other site
349124003328	ADP binding site [chemical binding]; other site
349124003329	catalytic site [active]
349124003330	transketolase; Reviewed; Region: PRK12753
349124003331	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
349124003332	TPP-binding site [chemical binding]; other site
349124003333	dimer interface [polypeptide binding]; other site
349124003334	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
349124003335	PYR/PP interface [polypeptide binding]; other site
349124003336	dimer interface [polypeptide binding]; other site
349124003337	TPP binding site [chemical binding]; other site
349124003338	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
349124003339	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
349124003340	MoxR-like ATPases [General function prediction only]; Region: COG0714
349124003341	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
349124003342	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
349124003343	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
349124003344	multimerization interface [polypeptide binding]; other site
349124003345	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
349124003346	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
349124003347	dimer interface [polypeptide binding]; other site
349124003348	catalytic residue [active]
349124003349	metal binding site [ion binding]; metal-binding site
349124003350	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349124003351	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349124003352	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
349124003353	putative dimerization interface [polypeptide binding]; other site
349124003354	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
349124003355	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
349124003356	substrate binding site [chemical binding]; other site
349124003357	hexamer interface [polypeptide binding]; other site
349124003358	metal binding site [ion binding]; metal-binding site
349124003359	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
349124003360	active site
349124003361	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
349124003362	dimer interface [polypeptide binding]; other site
349124003363	active site
349124003364	aspartate-rich active site metal binding site; other site
349124003365	allosteric magnesium binding site [ion binding]; other site
349124003366	Schiff base residues; other site
349124003367	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
349124003368	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
349124003369	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
349124003370	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
349124003371	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
349124003372	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
349124003373	shikimate binding site; other site
349124003374	NAD(P) binding site [chemical binding]; other site
349124003375	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
349124003376	dimer interaction site [polypeptide binding]; other site
349124003377	substrate-binding tunnel; other site
349124003378	active site
349124003379	catalytic site [active]
349124003380	substrate binding site [chemical binding]; other site
349124003381	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
349124003382	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
349124003383	active site
349124003384	dimer interface [polypeptide binding]; other site
349124003385	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
349124003386	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
349124003387	active site
349124003388	FMN binding site [chemical binding]; other site
349124003389	substrate binding site [chemical binding]; other site
349124003390	3Fe-4S cluster binding site [ion binding]; other site
349124003391	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
349124003392	domain interface; other site
349124003393	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
349124003394	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349124003395	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349124003396	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
349124003397	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
349124003398	substrate binding site [chemical binding]; other site
349124003399	active site
349124003400	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428
349124003401	active site
349124003402	Ap4A binding cleft/pocket [chemical binding]; other site
349124003403	P4 phosphate binding site; other site
349124003404	nudix motif; other site
349124003405	putative P2/P3 phosphate binding site [ion binding]; other site
349124003406	EamA-like transporter family; Region: EamA; pfam00892
349124003407	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
349124003408	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349124003409	N-terminal plug; other site
349124003410	ligand-binding site [chemical binding]; other site
349124003411	Uncharacterized conserved protein [Function unknown]; Region: COG5316
349124003412	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
349124003413	putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567
349124003414	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
349124003415	FAD binding pocket [chemical binding]; other site
349124003416	FAD binding motif [chemical binding]; other site
349124003417	phosphate binding motif [ion binding]; other site
349124003418	beta-alpha-beta structure motif; other site
349124003419	NAD binding pocket [chemical binding]; other site
349124003420	Iron coordination center [ion binding]; other site
349124003421	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
349124003422	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
349124003423	NADH(P)-binding; Region: NAD_binding_10; pfam13460
349124003424	NAD(P) binding site [chemical binding]; other site
349124003425	putative active site [active]
349124003426	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
349124003427	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
349124003428	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
349124003429	DNA-binding site [nucleotide binding]; DNA binding site
349124003430	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349124003431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124003432	homodimer interface [polypeptide binding]; other site
349124003433	catalytic residue [active]
349124003434	Methyltransferase domain; Region: Methyltransf_31; pfam13847
349124003435	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124003436	S-adenosylmethionine binding site [chemical binding]; other site
349124003437	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
349124003438	2-methylcitrate dehydratase; Region: prpD; TIGR02330
349124003439	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
349124003440	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
349124003441	dimer interface [polypeptide binding]; other site
349124003442	active site
349124003443	citrylCoA binding site [chemical binding]; other site
349124003444	oxalacetate/citrate binding site [chemical binding]; other site
349124003445	coenzyme A binding site [chemical binding]; other site
349124003446	catalytic triad [active]
349124003447	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
349124003448	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
349124003449	tetramer interface [polypeptide binding]; other site
349124003450	active site
349124003451	Mg2+/Mn2+ binding site [ion binding]; other site
349124003452	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
349124003453	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
349124003454	NADP binding site [chemical binding]; other site
349124003455	dimer interface [polypeptide binding]; other site
349124003456	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
349124003457	Predicted solute binding protein [General function prediction only]; Region: COG3889
349124003458	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
349124003459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124003460	putative PBP binding loops; other site
349124003461	dimer interface [polypeptide binding]; other site
349124003462	ABC-ATPase subunit interface; other site
349124003463	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
349124003464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124003465	putative PBP binding loops; other site
349124003466	ABC-ATPase subunit interface; other site
349124003467	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
349124003468	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349124003469	Walker A/P-loop; other site
349124003470	ATP binding site [chemical binding]; other site
349124003471	Q-loop/lid; other site
349124003472	ABC transporter signature motif; other site
349124003473	Walker B; other site
349124003474	D-loop; other site
349124003475	H-loop/switch region; other site
349124003476	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349124003477	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
349124003478	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
349124003479	Walker A/P-loop; other site
349124003480	ATP binding site [chemical binding]; other site
349124003481	Q-loop/lid; other site
349124003482	ABC transporter signature motif; other site
349124003483	Walker B; other site
349124003484	D-loop; other site
349124003485	H-loop/switch region; other site
349124003486	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
349124003487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124003488	S-adenosylmethionine binding site [chemical binding]; other site
349124003489	hypothetical protein; Provisional; Region: PRK10279
349124003490	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
349124003491	nucleophile elbow; other site
349124003492	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349124003493	Methyltransferase domain; Region: Methyltransf_12; pfam08242
349124003494	Predicted membrane protein [Function unknown]; Region: COG3650
349124003495	META domain; Region: META; pfam03724
349124003496	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
349124003497	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
349124003498	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349124003499	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349124003500	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
349124003501	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
349124003502	E3 interaction surface; other site
349124003503	lipoyl attachment site [posttranslational modification]; other site
349124003504	e3 binding domain; Region: E3_binding; pfam02817
349124003505	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
349124003506	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
349124003507	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
349124003508	TPP-binding site [chemical binding]; other site
349124003509	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
349124003510	dimer interface [polypeptide binding]; other site
349124003511	PYR/PP interface [polypeptide binding]; other site
349124003512	TPP binding site [chemical binding]; other site
349124003513	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
349124003514	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
349124003515	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
349124003516	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
349124003517	metal binding site [ion binding]; metal-binding site
349124003518	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
349124003519	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
349124003520	substrate binding site [chemical binding]; other site
349124003521	glutamase interaction surface [polypeptide binding]; other site
349124003522	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
349124003523	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
349124003524	catalytic residues [active]
349124003525	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
349124003526	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
349124003527	putative active site [active]
349124003528	oxyanion strand; other site
349124003529	catalytic triad [active]
349124003530	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
349124003531	putative active site pocket [active]
349124003532	4-fold oligomerization interface [polypeptide binding]; other site
349124003533	metal binding residues [ion binding]; metal-binding site
349124003534	3-fold/trimer interface [polypeptide binding]; other site
349124003535	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
349124003536	putative active site [active]
349124003537	dimerization interface [polypeptide binding]; other site
349124003538	putative tRNAtyr binding site [nucleotide binding]; other site
349124003539	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
349124003540	putative acyl-acceptor binding pocket; other site
349124003541	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
349124003542	Yqey-like protein; Region: YqeY; cl17540
349124003543	DNA primase; Validated; Region: dnaG; PRK05667
349124003544	CHC2 zinc finger; Region: zf-CHC2; pfam01807
349124003545	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
349124003546	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
349124003547	active site
349124003548	metal binding site [ion binding]; metal-binding site
349124003549	interdomain interaction site; other site
349124003550	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
349124003551	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
349124003552	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
349124003553	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
349124003554	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
349124003555	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
349124003556	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349124003557	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
349124003558	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349124003559	DNA binding residues [nucleotide binding]
349124003560	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
349124003561	hypothetical protein; Provisional; Region: PRK01254
349124003562	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
349124003563	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
349124003564	glycogen synthase; Provisional; Region: glgA; PRK00654
349124003565	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
349124003566	ADP-binding pocket [chemical binding]; other site
349124003567	homodimer interface [polypeptide binding]; other site
349124003568	glycogen branching enzyme; Provisional; Region: PRK05402
349124003569	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
349124003570	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
349124003571	active site
349124003572	catalytic site [active]
349124003573	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
349124003574	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
349124003575	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
349124003576	ligand binding site; other site
349124003577	oligomer interface; other site
349124003578	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
349124003579	dimer interface [polypeptide binding]; other site
349124003580	N-terminal domain interface [polypeptide binding]; other site
349124003581	sulfate 1 binding site; other site
349124003582	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
349124003583	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
349124003584	putative active site [active]
349124003585	catalytic site [active]
349124003586	4-alpha-glucanotransferase; Provisional; Region: PRK14508
349124003587	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
349124003588	putative homodimer interface [polypeptide binding]; other site
349124003589	putative active site pocket [active]
349124003590	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
349124003591	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
349124003592	DNA-binding site [nucleotide binding]; DNA binding site
349124003593	RNA-binding motif; other site
349124003594	Phasin protein; Region: Phasin_2; cl11491
349124003595	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349124003596	dimerization interface [polypeptide binding]; other site
349124003597	putative DNA binding site [nucleotide binding]; other site
349124003598	putative Zn2+ binding site [ion binding]; other site
349124003599	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
349124003600	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349124003601	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
349124003602	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
349124003603	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
349124003604	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
349124003605	active site
349124003606	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
349124003607	active site
349124003608	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
349124003609	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
349124003610	GAF domain; Region: GAF; pfam01590
349124003611	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124003612	dimer interface [polypeptide binding]; other site
349124003613	phosphorylation site [posttranslational modification]
349124003614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124003615	ATP binding site [chemical binding]; other site
349124003616	Mg2+ binding site [ion binding]; other site
349124003617	G-X-G motif; other site
349124003618	glucokinase, proteobacterial type; Region: glk; TIGR00749
349124003619	Glucokinase; Region: Glucokinase; cl17310
349124003620	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
349124003621	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
349124003622	active site
349124003623	homotetramer interface [polypeptide binding]; other site
349124003624	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
349124003625	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
349124003626	Uncharacterized conserved protein [Function unknown]; Region: COG2128
349124003627	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
349124003628	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
349124003629	GIY-YIG motif/motif A; other site
349124003630	putative active site [active]
349124003631	putative metal binding site [ion binding]; other site
349124003632	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124003633	PAS domain; Region: PAS_9; pfam13426
349124003634	putative active site [active]
349124003635	heme pocket [chemical binding]; other site
349124003636	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124003637	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124003638	dimer interface [polypeptide binding]; other site
349124003639	phosphorylation site [posttranslational modification]
349124003640	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124003641	ATP binding site [chemical binding]; other site
349124003642	Mg2+ binding site [ion binding]; other site
349124003643	G-X-G motif; other site
349124003644	Response regulator receiver domain; Region: Response_reg; pfam00072
349124003645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124003646	active site
349124003647	phosphorylation site [posttranslational modification]
349124003648	intermolecular recognition site; other site
349124003649	dimerization interface [polypeptide binding]; other site
349124003650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124003651	PAS fold; Region: PAS_3; pfam08447
349124003652	putative active site [active]
349124003653	heme pocket [chemical binding]; other site
349124003654	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124003655	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124003656	dimer interface [polypeptide binding]; other site
349124003657	putative CheW interface [polypeptide binding]; other site
349124003658	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
349124003659	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
349124003660	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
349124003661	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
349124003662	dimer interface [polypeptide binding]; other site
349124003663	tetramer interface [polypeptide binding]; other site
349124003664	PYR/PP interface [polypeptide binding]; other site
349124003665	TPP binding site [chemical binding]; other site
349124003666	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
349124003667	TPP-binding site; other site
349124003668	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
349124003669	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
349124003670	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
349124003671	substrate binding site [chemical binding]; other site
349124003672	oxyanion hole (OAH) forming residues; other site
349124003673	trimer interface [polypeptide binding]; other site
349124003674	O-succinylbenzoate synthase; Provisional; Region: PRK05105
349124003675	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
349124003676	metal binding site [ion binding]; metal-binding site
349124003677	substrate binding pocket [chemical binding]; other site
349124003678	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
349124003679	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
349124003680	acyl-activating enzyme (AAE) consensus motif; other site
349124003681	putative AMP binding site [chemical binding]; other site
349124003682	putative active site [active]
349124003683	putative CoA binding site [chemical binding]; other site
349124003684	MAPEG family; Region: MAPEG; cl09190
349124003685	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
349124003686	dimer interface [polypeptide binding]; other site
349124003687	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
349124003688	Domain of unknown function DUF20; Region: UPF0118; pfam01594
349124003689	lytic murein transglycosylase; Provisional; Region: PRK11619
349124003690	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349124003691	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349124003692	catalytic residue [active]
349124003693	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
349124003694	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
349124003695	catalytic site [active]
349124003696	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
349124003697	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
349124003698	MPT binding site; other site
349124003699	trimer interface [polypeptide binding]; other site
349124003700	AsmA family; Region: AsmA; pfam05170
349124003701	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
349124003702	Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811
349124003703	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
349124003704	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
349124003705	minor groove reading motif; other site
349124003706	helix-hairpin-helix signature motif; other site
349124003707	substrate binding pocket [chemical binding]; other site
349124003708	active site
349124003709	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
349124003710	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
349124003711	DNA binding and oxoG recognition site [nucleotide binding]
349124003712	oxidative damage protection protein; Provisional; Region: PRK05408
349124003713	integrase; Provisional; Region: PRK09692
349124003714	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
349124003715	active site
349124003716	Int/Topo IB signature motif; other site
349124003717	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
349124003718	Transposase; Region: HTH_Tnp_1; cl17663
349124003719	HTH-like domain; Region: HTH_21; pfam13276
349124003720	Integrase core domain; Region: rve; pfam00665
349124003721	Integrase core domain; Region: rve_3; pfam13683
349124003722	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349124003723	ATP binding site [chemical binding]; other site
349124003724	putative Mg++ binding site [ion binding]; other site
349124003725	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
349124003726	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
349124003727	Protein of unknown function DUF91; Region: DUF91; cl00709
349124003728	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
349124003729	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
349124003730	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
349124003731	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
349124003732	GIY-YIG motif/motif A; other site
349124003733	putative active site [active]
349124003734	putative metal binding site [ion binding]; other site
349124003735	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
349124003736	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
349124003737	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
349124003738	Abi-like protein; Region: Abi_2; pfam07751
349124003739	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
349124003740	HsdM N-terminal domain; Region: HsdM_N; pfam12161
349124003741	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124003742	S-adenosylmethionine binding site [chemical binding]; other site
349124003743	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
349124003744	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
349124003745	catalytic tetrad [active]
349124003746	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
349124003747	2'-5' RNA ligase; Provisional; Region: PRK15124
349124003748	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
349124003749	Cytochrome c; Region: Cytochrom_C; pfam00034
349124003750	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
349124003751	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
349124003752	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
349124003753	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
349124003754	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
349124003755	thiosulfate reductase PhsA; Provisional; Region: PRK15488
349124003756	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
349124003757	putative [Fe4-S4] binding site [ion binding]; other site
349124003758	putative molybdopterin cofactor binding site [chemical binding]; other site
349124003759	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
349124003760	putative molybdopterin cofactor binding site; other site
349124003761	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
349124003762	Cytochrome c; Region: Cytochrom_C; cl11414
349124003763	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
349124003764	ABC1 family; Region: ABC1; cl17513
349124003765	Bacterial PH domain; Region: DUF304; pfam03703
349124003766	Predicted membrane protein [Function unknown]; Region: COG2259
349124003767	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
349124003768	UbiA prenyltransferase family; Region: UbiA; pfam01040
349124003769	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
349124003770	MoaE interaction surface [polypeptide binding]; other site
349124003771	MoeB interaction surface [polypeptide binding]; other site
349124003772	thiocarboxylated glycine; other site
349124003773	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
349124003774	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
349124003775	tetramer (dimer of dimers) interface [polypeptide binding]; other site
349124003776	active site
349124003777	dimer interface [polypeptide binding]; other site
349124003778	threonine dehydratase; Reviewed; Region: PRK09224
349124003779	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
349124003780	tetramer interface [polypeptide binding]; other site
349124003781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124003782	catalytic residue [active]
349124003783	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
349124003784	putative Ile/Val binding site [chemical binding]; other site
349124003785	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
349124003786	putative Ile/Val binding site [chemical binding]; other site
349124003787	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
349124003788	putative active site [active]
349124003789	putative metal binding site [ion binding]; other site
349124003790	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
349124003791	EVE domain; Region: EVE; cl00728
349124003792	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
349124003793	Cell division protein ZapA; Region: ZapA; pfam05164
349124003794	TIGR02449 family protein; Region: TIGR02449
349124003795	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
349124003796	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
349124003797	proline aminopeptidase P II; Provisional; Region: PRK10879
349124003798	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
349124003799	active site
349124003800	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
349124003801	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
349124003802	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
349124003803	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
349124003804	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
349124003805	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
349124003806	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
349124003807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124003808	dimer interface [polypeptide binding]; other site
349124003809	conserved gate region; other site
349124003810	putative PBP binding loops; other site
349124003811	ABC-ATPase subunit interface; other site
349124003812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
349124003813	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
349124003814	Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability; Region: TRFH; cl02779
349124003815	dimer interface [polypeptide binding]; other site
349124003816	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
349124003817	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
349124003818	lipoyl attachment site [posttranslational modification]; other site
349124003819	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
349124003820	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
349124003821	tetramer interface [polypeptide binding]; other site
349124003822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124003823	catalytic residue [active]
349124003824	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
349124003825	dimer interface [polypeptide binding]; other site
349124003826	catalytic triad [active]
349124003827	peroxidatic and resolving cysteines [active]
349124003828	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
349124003829	tetramer interface [polypeptide binding]; other site
349124003830	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124003831	catalytic residue [active]
349124003832	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
349124003833	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
349124003834	substrate binding site [chemical binding]; other site
349124003835	ATP binding site [chemical binding]; other site
349124003836	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
349124003837	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
349124003838	amidase catalytic site [active]
349124003839	Zn binding residues [ion binding]; other site
349124003840	substrate binding site [chemical binding]; other site
349124003841	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
349124003842	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
349124003843	active site
349124003844	metal binding site [ion binding]; metal-binding site
349124003845	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
349124003846	putative active site [active]
349124003847	transaldolase; Provisional; Region: PRK03903
349124003848	catalytic residue [active]
349124003849	diaminopimelate decarboxylase; Region: lysA; TIGR01048
349124003850	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
349124003851	active site
349124003852	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349124003853	substrate binding site [chemical binding]; other site
349124003854	catalytic residues [active]
349124003855	dimer interface [polypeptide binding]; other site
349124003856	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
349124003857	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
349124003858	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
349124003859	Protein of unknown function, DUF484; Region: DUF484; cl17449
349124003860	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
349124003861	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349124003862	active site
349124003863	DNA binding site [nucleotide binding]
349124003864	Int/Topo IB signature motif; other site
349124003865	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
349124003866	active site
349124003867	HslU subunit interaction site [polypeptide binding]; other site
349124003868	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
349124003869	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124003870	Walker A motif; other site
349124003871	ATP binding site [chemical binding]; other site
349124003872	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
349124003873	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
349124003874	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
349124003875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124003876	S-adenosylmethionine binding site [chemical binding]; other site
349124003877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
349124003878	SCP-2 sterol transfer family; Region: SCP2; pfam02036
349124003879	ABC1 family; Region: ABC1; cl17513
349124003880	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
349124003881	DJ-1 family protein; Region: not_thiJ; TIGR01383
349124003882	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
349124003883	conserved cys residue [active]
349124003884	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
349124003885	putative active site [active]
349124003886	NodB motif; other site
349124003887	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
349124003888	C-terminal peptidase (prc); Region: prc; TIGR00225
349124003889	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
349124003890	protein binding site [polypeptide binding]; other site
349124003891	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
349124003892	Catalytic dyad [active]
349124003893	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
349124003894	Peptidase family M23; Region: Peptidase_M23; pfam01551
349124003895	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
349124003896	active site residue [active]
349124003897	preprotein translocase subunit SecB; Validated; Region: PRK05751
349124003898	SecA binding site; other site
349124003899	Preprotein binding site; other site
349124003900	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
349124003901	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
349124003902	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
349124003903	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
349124003904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124003905	active site
349124003906	phosphorylation site [posttranslational modification]
349124003907	intermolecular recognition site; other site
349124003908	dimerization interface [polypeptide binding]; other site
349124003909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124003910	Walker A motif; other site
349124003911	ATP binding site [chemical binding]; other site
349124003912	Walker B motif; other site
349124003913	arginine finger; other site
349124003914	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349124003915	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
349124003916	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124003917	putative active site [active]
349124003918	heme pocket [chemical binding]; other site
349124003919	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124003920	dimer interface [polypeptide binding]; other site
349124003921	phosphorylation site [posttranslational modification]
349124003922	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124003923	ATP binding site [chemical binding]; other site
349124003924	Mg2+ binding site [ion binding]; other site
349124003925	G-X-G motif; other site
349124003926	glutamine synthetase; Provisional; Region: glnA; PRK09469
349124003927	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
349124003928	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
349124003929	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
349124003930	CPxP  motif; other site
349124003931	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
349124003932	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
349124003933	Ligand Binding Site [chemical binding]; other site
349124003934	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
349124003935	dimer interface [polypeptide binding]; other site
349124003936	motif 1; other site
349124003937	active site
349124003938	motif 2; other site
349124003939	motif 3; other site
349124003940	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
349124003941	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
349124003942	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
349124003943	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349124003944	active site
349124003945	motif I; other site
349124003946	motif II; other site
349124003947	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349124003948	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
349124003949	putative acyl-acceptor binding pocket; other site
349124003950	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
349124003951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124003952	ATP binding site [chemical binding]; other site
349124003953	Mg2+ binding site [ion binding]; other site
349124003954	G-X-G motif; other site
349124003955	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
349124003956	anchoring element; other site
349124003957	dimer interface [polypeptide binding]; other site
349124003958	ATP binding site [chemical binding]; other site
349124003959	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
349124003960	active site
349124003961	putative metal-binding site [ion binding]; other site
349124003962	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
349124003963	recombination protein F; Reviewed; Region: recF; PRK00064
349124003964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124003965	Walker A/P-loop; other site
349124003966	ATP binding site [chemical binding]; other site
349124003967	Q-loop/lid; other site
349124003968	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124003969	ABC transporter signature motif; other site
349124003970	Walker B; other site
349124003971	D-loop; other site
349124003972	H-loop/switch region; other site
349124003973	DNA polymerase III subunit beta; Validated; Region: PRK05643
349124003974	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
349124003975	putative DNA binding surface [nucleotide binding]; other site
349124003976	dimer interface [polypeptide binding]; other site
349124003977	beta-clamp/clamp loader binding surface; other site
349124003978	beta-clamp/translesion DNA polymerase binding surface; other site
349124003979	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
349124003980	DnaA N-terminal domain; Region: DnaA_N; pfam11638
349124003981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124003982	Walker A motif; other site
349124003983	ATP binding site [chemical binding]; other site
349124003984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
349124003985	Walker B motif; other site
349124003986	arginine finger; other site
349124003987	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
349124003988	DnaA box-binding interface [nucleotide binding]; other site
349124003989	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
349124003990	Ribonuclease P; Region: Ribonuclease_P; cl00457
349124003991	membrane protein insertase; Provisional; Region: PRK01318
349124003992	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
349124003993	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
349124003994	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
349124003995	trmE is a tRNA modification GTPase; Region: trmE; cd04164
349124003996	G1 box; other site
349124003997	GTP/Mg2+ binding site [chemical binding]; other site
349124003998	Switch I region; other site
349124003999	G2 box; other site
349124004000	Switch II region; other site
349124004001	G3 box; other site
349124004002	G4 box; other site
349124004003	G5 box; other site
349124004004	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
349124004005	acyl carrier protein; Provisional; Region: acpP; PRK00982
349124004006	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
349124004007	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
349124004008	NAD(P) binding site [chemical binding]; other site
349124004009	homotetramer interface [polypeptide binding]; other site
349124004010	homodimer interface [polypeptide binding]; other site
349124004011	active site
349124004012	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
349124004013	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
349124004014	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
349124004015	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
349124004016	dimer interface [polypeptide binding]; other site
349124004017	active site
349124004018	CoA binding pocket [chemical binding]; other site
349124004019	putative phosphate acyltransferase; Provisional; Region: PRK05331
349124004020	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
349124004021	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
349124004022	Maf-like protein; Region: Maf; pfam02545
349124004023	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
349124004024	active site
349124004025	dimer interface [polypeptide binding]; other site
349124004026	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
349124004027	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
349124004028	tandem repeat interface [polypeptide binding]; other site
349124004029	oligomer interface [polypeptide binding]; other site
349124004030	active site residues [active]
349124004031	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
349124004032	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349124004033	RNA binding surface [nucleotide binding]; other site
349124004034	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349124004035	active site
349124004036	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
349124004037	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
349124004038	homodimer interface [polypeptide binding]; other site
349124004039	oligonucleotide binding site [chemical binding]; other site
349124004040	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
349124004041	Low molecular weight phosphatase family; Region: LMWPc; cd00115
349124004042	active site
349124004043	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
349124004044	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
349124004045	Ligand binding site; other site
349124004046	oligomer interface; other site
349124004047	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
349124004048	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
349124004049	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
349124004050	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349124004051	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
349124004052	Walker A/P-loop; other site
349124004053	ATP binding site [chemical binding]; other site
349124004054	Q-loop/lid; other site
349124004055	ABC transporter signature motif; other site
349124004056	Walker B; other site
349124004057	D-loop; other site
349124004058	H-loop/switch region; other site
349124004059	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
349124004060	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
349124004061	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
349124004062	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
349124004063	Competence protein; Region: Competence; pfam03772
349124004064	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
349124004065	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
349124004066	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349124004067	Walker A/P-loop; other site
349124004068	ATP binding site [chemical binding]; other site
349124004069	Q-loop/lid; other site
349124004070	ABC transporter signature motif; other site
349124004071	Walker B; other site
349124004072	D-loop; other site
349124004073	H-loop/switch region; other site
349124004074	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
349124004075	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349124004076	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
349124004077	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
349124004078	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
349124004079	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
349124004080	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
349124004081	putative active site; other site
349124004082	catalytic triad [active]
349124004083	putative dimer interface [polypeptide binding]; other site
349124004084	Predicted membrane protein [Function unknown]; Region: COG3671
349124004085	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
349124004086	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
349124004087	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349124004088	ATP binding site [chemical binding]; other site
349124004089	putative Mg++ binding site [ion binding]; other site
349124004090	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349124004091	nucleotide binding region [chemical binding]; other site
349124004092	ATP-binding site [chemical binding]; other site
349124004093	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
349124004094	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
349124004095	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
349124004096	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349124004097	active site
349124004098	beta-hexosaminidase; Provisional; Region: PRK05337
349124004099	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
349124004100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
349124004101	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
349124004102	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
349124004103	putative active site [active]
349124004104	putative metal binding residues [ion binding]; other site
349124004105	signature motif; other site
349124004106	putative dimer interface [polypeptide binding]; other site
349124004107	putative phosphate binding site [ion binding]; other site
349124004108	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349124004109	catalytic core [active]
349124004110	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349124004111	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
349124004112	trimer interface [polypeptide binding]; other site
349124004113	dimer interface [polypeptide binding]; other site
349124004114	putative active site [active]
349124004115	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
349124004116	aromatic arch; other site
349124004117	DCoH dimer interaction site [polypeptide binding]; other site
349124004118	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
349124004119	DCoH tetramer interaction site [polypeptide binding]; other site
349124004120	substrate binding site [chemical binding]; other site
349124004121	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
349124004122	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
349124004123	MOFRL family; Region: MOFRL; pfam05161
349124004124	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
349124004125	ThiC-associated domain; Region: ThiC-associated; pfam13667
349124004126	ThiC family; Region: ThiC; pfam01964
349124004127	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
349124004128	AAA domain; Region: AAA_30; pfam13604
349124004129	Family description; Region: UvrD_C_2; pfam13538
349124004130	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
349124004131	Part of AAA domain; Region: AAA_19; pfam13245
349124004132	Family description; Region: UvrD_C_2; pfam13538
349124004133	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
349124004134	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
349124004135	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
349124004136	Protein of unknown function, DUF393; Region: DUF393; pfam04134
349124004137	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
349124004138	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
349124004139	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
349124004140	active site
349124004141	HIGH motif; other site
349124004142	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
349124004143	active site
349124004144	KMSKS motif; other site
349124004145	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
349124004146	Helix-turn-helix domain; Region: HTH_38; pfam13936
349124004147	Integrase core domain; Region: rve; pfam00665
349124004148	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
349124004149	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
349124004150	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
349124004151	Catalytic site [active]
349124004152	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
349124004153	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
349124004154	active site
349124004155	DNA binding site [nucleotide binding]
349124004156	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
349124004157	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
349124004158	Helix-hairpin-helix motif; Region: HHH; pfam00633
349124004159	Predicted transcriptional regulator [Transcription]; Region: COG2378
349124004160	WYL domain; Region: WYL; pfam13280
349124004161	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
349124004162	Integrase core domain; Region: rve; pfam00665
349124004163	Transposase; Region: HTH_Tnp_1; cl17663
349124004164	putative transposase OrfB; Reviewed; Region: PHA02517
349124004165	HTH-like domain; Region: HTH_21; pfam13276
349124004166	Integrase core domain; Region: rve; pfam00665
349124004167	Integrase core domain; Region: rve_3; pfam13683
349124004168	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
349124004169	structural tetrad; other site
349124004170	PQQ-like domain; Region: PQQ_2; pfam13360
349124004171	HTH-like domain; Region: HTH_21; pfam13276
349124004172	Integrase core domain; Region: rve; pfam00665
349124004173	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
349124004174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
349124004175	Helix-turn-helix domain; Region: HTH_17; pfam12728
349124004176	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
349124004177	homodimer interface [polypeptide binding]; other site
349124004178	chemical substrate binding site [chemical binding]; other site
349124004179	oligomer interface [polypeptide binding]; other site
349124004180	metal binding site [ion binding]; metal-binding site
349124004181	Part of AAA domain; Region: AAA_19; pfam13245
349124004182	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
349124004183	Uncharacterized conserved protein [Function unknown]; Region: COG3410
349124004184	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
349124004185	Catalytic site [active]
349124004186	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
349124004187	Y-family of DNA polymerases; Region: PolY; cl12025
349124004188	DNA binding site [nucleotide binding]
349124004189	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
349124004190	Helix-hairpin-helix motif; Region: HHH; pfam00633
349124004191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
349124004192	Helix-turn-helix domain; Region: HTH_28; pfam13518
349124004193	putative transposase OrfB; Reviewed; Region: PHA02517
349124004194	HTH-like domain; Region: HTH_21; pfam13276
349124004195	Integrase core domain; Region: rve; pfam00665
349124004196	Integrase core domain; Region: rve_2; pfam13333
349124004197	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124004198	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124004199	metal binding site [ion binding]; metal-binding site
349124004200	active site
349124004201	I-site; other site
349124004202	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
349124004203	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
349124004204	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
349124004205	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
349124004206	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349124004207	ykoK element as predicted by Rfam (RF00380), score 105.49
349124004208	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
349124004209	Divalent cation transporter; Region: MgtE; cl00786
349124004210	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
349124004211	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124004212	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124004213	ATP binding site [chemical binding]; other site
349124004214	Mg2+ binding site [ion binding]; other site
349124004215	G-X-G motif; other site
349124004216	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
349124004217	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
349124004218	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
349124004219	DNA binding site [nucleotide binding]
349124004220	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349124004221	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
349124004222	classical (c) SDRs; Region: SDR_c; cd05233
349124004223	acetoin reductases; Region: 23BDH; TIGR02415
349124004224	NAD(P) binding site [chemical binding]; other site
349124004225	active site
349124004226	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
349124004227	Cytochrome C' Region: Cytochrom_C_2; pfam01322
349124004228	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
349124004229	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
349124004230	PAS fold; Region: PAS_4; pfam08448
349124004231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124004232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124004233	dimer interface [polypeptide binding]; other site
349124004234	phosphorylation site [posttranslational modification]
349124004235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124004236	ATP binding site [chemical binding]; other site
349124004237	Mg2+ binding site [ion binding]; other site
349124004238	G-X-G motif; other site
349124004239	Response regulator receiver domain; Region: Response_reg; pfam00072
349124004240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124004241	active site
349124004242	phosphorylation site [posttranslational modification]
349124004243	intermolecular recognition site; other site
349124004244	dimerization interface [polypeptide binding]; other site
349124004245	short chain dehydrogenase; Provisional; Region: PRK12827
349124004246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349124004247	NAD(P) binding site [chemical binding]; other site
349124004248	active site
349124004249	Cytochrome c; Region: Cytochrom_C; cl11414
349124004250	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
349124004251	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
349124004252	AsmA family; Region: AsmA; pfam05170
349124004253	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
349124004254	PAS fold; Region: PAS; pfam00989
349124004255	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124004256	putative active site [active]
349124004257	heme pocket [chemical binding]; other site
349124004258	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
349124004259	catalytic residues [active]
349124004260	PAS fold; Region: PAS; pfam00989
349124004261	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124004262	putative active site [active]
349124004263	heme pocket [chemical binding]; other site
349124004264	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124004265	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124004266	ATP binding site [chemical binding]; other site
349124004267	Mg2+ binding site [ion binding]; other site
349124004268	G-X-G motif; other site
349124004269	Response regulator receiver domain; Region: Response_reg; pfam00072
349124004270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124004271	active site
349124004272	phosphorylation site [posttranslational modification]
349124004273	intermolecular recognition site; other site
349124004274	dimerization interface [polypeptide binding]; other site
349124004275	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124004276	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
349124004277	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124004278	phosphorylation site [posttranslational modification]
349124004279	dimer interface [polypeptide binding]; other site
349124004280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124004281	ATP binding site [chemical binding]; other site
349124004282	Mg2+ binding site [ion binding]; other site
349124004283	G-X-G motif; other site
349124004284	response regulator GlrR; Provisional; Region: PRK15115
349124004285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124004286	active site
349124004287	phosphorylation site [posttranslational modification]
349124004288	intermolecular recognition site; other site
349124004289	dimerization interface [polypeptide binding]; other site
349124004290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124004291	Walker A motif; other site
349124004292	ATP binding site [chemical binding]; other site
349124004293	Walker B motif; other site
349124004294	arginine finger; other site
349124004295	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
349124004296	Predicted flavoproteins [General function prediction only]; Region: COG2081
349124004297	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349124004298	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
349124004299	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349124004300	ATP binding site [chemical binding]; other site
349124004301	putative Mg++ binding site [ion binding]; other site
349124004302	helicase superfamily c-terminal domain; Region: HELICc; smart00490
349124004303	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
349124004304	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
349124004305	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
349124004306	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
349124004307	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
349124004308	active site
349124004309	SAM binding site [chemical binding]; other site
349124004310	homodimer interface [polypeptide binding]; other site
349124004311	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
349124004312	active site
349124004313	SAM binding site [chemical binding]; other site
349124004314	homodimer interface [polypeptide binding]; other site
349124004315	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
349124004316	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
349124004317	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
349124004318	active site
349124004319	SAM binding site [chemical binding]; other site
349124004320	homodimer interface [polypeptide binding]; other site
349124004321	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
349124004322	active site
349124004323	putative homodimer interface [polypeptide binding]; other site
349124004324	SAM binding site [chemical binding]; other site
349124004325	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
349124004326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124004327	S-adenosylmethionine binding site [chemical binding]; other site
349124004328	Precorrin-8X methylmutase; Region: CbiC; pfam02570
349124004329	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
349124004330	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
349124004331	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
349124004332	putative active site [active]
349124004333	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
349124004334	putative active site [active]
349124004335	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
349124004336	active site
349124004337	SAM binding site [chemical binding]; other site
349124004338	homodimer interface [polypeptide binding]; other site
349124004339	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
349124004340	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
349124004341	Walker A/P-loop; other site
349124004342	ATP binding site [chemical binding]; other site
349124004343	Q-loop/lid; other site
349124004344	ABC transporter signature motif; other site
349124004345	Walker B; other site
349124004346	D-loop; other site
349124004347	H-loop/switch region; other site
349124004348	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
349124004349	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349124004350	ABC-ATPase subunit  interface; other site
349124004351	dimer interface [polypeptide binding]; other site
349124004352	putative PBP binding regions; other site
349124004353	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
349124004354	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
349124004355	intersubunit interface [polypeptide binding]; other site
349124004356	GAF domain; Region: GAF; pfam01590
349124004357	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
349124004358	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349124004359	Zn2+ binding site [ion binding]; other site
349124004360	Mg2+ binding site [ion binding]; other site
349124004361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124004362	S-adenosylmethionine binding site [chemical binding]; other site
349124004363	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349124004364	Zn2+ binding site [ion binding]; other site
349124004365	Mg2+ binding site [ion binding]; other site
349124004366	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124004367	metal binding site [ion binding]; metal-binding site
349124004368	active site
349124004369	I-site; other site
349124004370	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
349124004371	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
349124004372	catalytic triad [active]
349124004373	antiporter inner membrane protein; Provisional; Region: PRK11670
349124004374	Domain of unknown function DUF59; Region: DUF59; pfam01883
349124004375	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
349124004376	Walker A motif; other site
349124004377	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
349124004378	MoaE homodimer interface [polypeptide binding]; other site
349124004379	MoaD interaction [polypeptide binding]; other site
349124004380	active site residues [active]
349124004381	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
349124004382	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349124004383	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
349124004384	Walker A/P-loop; other site
349124004385	ATP binding site [chemical binding]; other site
349124004386	Q-loop/lid; other site
349124004387	ABC transporter signature motif; other site
349124004388	Walker B; other site
349124004389	D-loop; other site
349124004390	H-loop/switch region; other site
349124004391	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
349124004392	High potential iron-sulfur protein; Region: HIPIP; pfam01355
349124004393	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124004394	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
349124004395	Walker A/P-loop; other site
349124004396	ATP binding site [chemical binding]; other site
349124004397	Q-loop/lid; other site
349124004398	ABC transporter signature motif; other site
349124004399	Walker B; other site
349124004400	D-loop; other site
349124004401	H-loop/switch region; other site
349124004402	CcmB protein; Region: CcmB; pfam03379
349124004403	heme exporter protein CcmC; Region: ccmC; TIGR01191
349124004404	Heme exporter protein D (CcmD); Region: CcmD; cl11475
349124004405	CcmE; Region: CcmE; pfam03100
349124004406	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
349124004407	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
349124004408	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349124004409	catalytic residues [active]
349124004410	central insert; other site
349124004411	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
349124004412	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
349124004413	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
349124004414	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124004415	binding surface
349124004416	TPR motif; other site
349124004417	Cytochrome c552; Region: Cytochrom_C552; pfam02335
349124004418	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
349124004419	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
349124004420	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349124004421	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349124004422	CoenzymeA binding site [chemical binding]; other site
349124004423	subunit interaction site [polypeptide binding]; other site
349124004424	PHB binding site; other site
349124004425	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
349124004426	CoenzymeA binding site [chemical binding]; other site
349124004427	subunit interaction site [polypeptide binding]; other site
349124004428	PHB binding site; other site
349124004429	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
349124004430	methionine sulfoxide reductase A; Provisional; Region: PRK14054
349124004431	Response regulator receiver domain; Region: Response_reg; pfam00072
349124004432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124004433	active site
349124004434	phosphorylation site [posttranslational modification]
349124004435	intermolecular recognition site; other site
349124004436	dimerization interface [polypeptide binding]; other site
349124004437	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
349124004438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124004439	active site
349124004440	phosphorylation site [posttranslational modification]
349124004441	intermolecular recognition site; other site
349124004442	dimerization interface [polypeptide binding]; other site
349124004443	Predicted permease; Region: DUF318; cl17795
349124004444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124004445	S-adenosylmethionine binding site [chemical binding]; other site
349124004446	BCCT family transporter; Region: BCCT; pfam02028
349124004447	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
349124004448	Helicase; Region: Helicase_RecD; pfam05127
349124004449	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349124004450	Coenzyme A binding pocket [chemical binding]; other site
349124004451	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
349124004452	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
349124004453	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349124004454	ATP binding site [chemical binding]; other site
349124004455	putative Mg++ binding site [ion binding]; other site
349124004456	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349124004457	nucleotide binding region [chemical binding]; other site
349124004458	ATP-binding site [chemical binding]; other site
349124004459	Helicase associated domain (HA2); Region: HA2; pfam04408
349124004460	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
349124004461	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
349124004462	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
349124004463	active site
349124004464	metal binding site [ion binding]; metal-binding site
349124004465	homotetramer interface [polypeptide binding]; other site
349124004466	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
349124004467	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
349124004468	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
349124004469	YccA-like proteins; Region: YccA_like; cd10433
349124004470	seryl-tRNA synthetase; Provisional; Region: PRK05431
349124004471	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
349124004472	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
349124004473	dimer interface [polypeptide binding]; other site
349124004474	active site
349124004475	motif 1; other site
349124004476	motif 2; other site
349124004477	motif 3; other site
349124004478	recombination factor protein RarA; Reviewed; Region: PRK13342
349124004479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124004480	Walker A motif; other site
349124004481	ATP binding site [chemical binding]; other site
349124004482	Walker B motif; other site
349124004483	arginine finger; other site
349124004484	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
349124004485	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
349124004486	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
349124004487	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124004488	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124004489	metal binding site [ion binding]; metal-binding site
349124004490	active site
349124004491	I-site; other site
349124004492	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
349124004493	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
349124004494	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
349124004495	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
349124004496	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
349124004497	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
349124004498	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
349124004499	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
349124004500	rRNA binding site [nucleotide binding]; other site
349124004501	predicted 30S ribosome binding site; other site
349124004502	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
349124004503	Clp amino terminal domain; Region: Clp_N; pfam02861
349124004504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124004505	Walker A motif; other site
349124004506	ATP binding site [chemical binding]; other site
349124004507	Walker B motif; other site
349124004508	arginine finger; other site
349124004509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124004510	Walker A motif; other site
349124004511	ATP binding site [chemical binding]; other site
349124004512	Walker B motif; other site
349124004513	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
349124004514	Uncharacterized conserved protein [Function unknown]; Region: COG2127
349124004515	isocitrate lyase; Provisional; Region: PRK15063
349124004516	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
349124004517	tetramer interface [polypeptide binding]; other site
349124004518	active site
349124004519	Mg2+/Mn2+ binding site [ion binding]; other site
349124004520	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349124004521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349124004522	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
349124004523	dimerization interface [polypeptide binding]; other site
349124004524	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
349124004525	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
349124004526	Ligand Binding Site [chemical binding]; other site
349124004527	Protein of unknown function (DUF489); Region: DUF489; pfam04356
349124004528	aconitate hydratase; Validated; Region: PRK09277
349124004529	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
349124004530	substrate binding site [chemical binding]; other site
349124004531	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
349124004532	ligand binding site [chemical binding]; other site
349124004533	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
349124004534	substrate binding site [chemical binding]; other site
349124004535	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
349124004536	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
349124004537	active site
349124004538	catalytic residues [active]
349124004539	metal binding site [ion binding]; metal-binding site
349124004540	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
349124004541	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
349124004542	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349124004543	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349124004544	ligand binding site [chemical binding]; other site
349124004545	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
349124004546	active site
349124004547	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124004548	Ligand Binding Site [chemical binding]; other site
349124004549	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124004550	Ligand Binding Site [chemical binding]; other site
349124004551	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
349124004552	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349124004553	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349124004554	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349124004555	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349124004556	Walker A/P-loop; other site
349124004557	ATP binding site [chemical binding]; other site
349124004558	Q-loop/lid; other site
349124004559	ABC transporter signature motif; other site
349124004560	Walker B; other site
349124004561	D-loop; other site
349124004562	H-loop/switch region; other site
349124004563	DsrE/DsrF-like family; Region: DrsE; pfam02635
349124004564	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
349124004565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124004566	active site
349124004567	phosphorylation site [posttranslational modification]
349124004568	intermolecular recognition site; other site
349124004569	dimerization interface [polypeptide binding]; other site
349124004570	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349124004571	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124004572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124004573	ATP binding site [chemical binding]; other site
349124004574	G-X-G motif; other site
349124004575	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349124004576	dimerization interface [polypeptide binding]; other site
349124004577	putative DNA binding site [nucleotide binding]; other site
349124004578	putative Zn2+ binding site [ion binding]; other site
349124004579	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
349124004580	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
349124004581	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
349124004582	putative DNA binding site [nucleotide binding]; other site
349124004583	putative Zn2+ binding site [ion binding]; other site
349124004584	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
349124004585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124004586	active site
349124004587	phosphorylation site [posttranslational modification]
349124004588	intermolecular recognition site; other site
349124004589	dimerization interface [polypeptide binding]; other site
349124004590	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
349124004591	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
349124004592	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349124004593	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
349124004594	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349124004595	DNA binding residues [nucleotide binding]
349124004596	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349124004597	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
349124004598	Peptidase family M23; Region: Peptidase_M23; pfam01551
349124004599	Predicted membrane protein [Function unknown]; Region: COG1238
349124004600	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
349124004601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124004602	S-adenosylmethionine binding site [chemical binding]; other site
349124004603	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
349124004604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
349124004605	Smr domain; Region: Smr; pfam01713
349124004606	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
349124004607	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
349124004608	Permutation of conserved domain; other site
349124004609	active site
349124004610	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
349124004611	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
349124004612	homotrimer interaction site [polypeptide binding]; other site
349124004613	zinc binding site [ion binding]; other site
349124004614	CDP-binding sites; other site
349124004615	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
349124004616	substrate binding site; other site
349124004617	dimer interface; other site
349124004618	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
349124004619	Septum formation initiator; Region: DivIC; cl17659
349124004620	enolase; Provisional; Region: eno; PRK00077
349124004621	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
349124004622	dimer interface [polypeptide binding]; other site
349124004623	metal binding site [ion binding]; metal-binding site
349124004624	substrate binding pocket [chemical binding]; other site
349124004625	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
349124004626	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
349124004627	CTP synthetase; Validated; Region: pyrG; PRK05380
349124004628	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
349124004629	Catalytic site [active]
349124004630	active site
349124004631	UTP binding site [chemical binding]; other site
349124004632	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
349124004633	active site
349124004634	putative oxyanion hole; other site
349124004635	catalytic triad [active]
349124004636	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349124004637	non-specific DNA binding site [nucleotide binding]; other site
349124004638	salt bridge; other site
349124004639	sequence-specific DNA binding site [nucleotide binding]; other site
349124004640	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
349124004641	Zn binding site [ion binding]; other site
349124004642	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
349124004643	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
349124004644	Ligand Binding Site [chemical binding]; other site
349124004645	TilS substrate binding domain; Region: TilS; pfam09179
349124004646	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
349124004647	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
349124004648	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
349124004649	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
349124004650	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
349124004651	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124004652	PAS domain; Region: PAS_9; pfam13426
349124004653	putative active site [active]
349124004654	heme pocket [chemical binding]; other site
349124004655	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124004656	PAS domain; Region: PAS_9; pfam13426
349124004657	putative active site [active]
349124004658	heme pocket [chemical binding]; other site
349124004659	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124004660	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124004661	metal binding site [ion binding]; metal-binding site
349124004662	active site
349124004663	I-site; other site
349124004664	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124004665	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
349124004666	proximal heme binding site [chemical binding]; other site
349124004667	Iron-sulfur protein interface; other site
349124004668	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
349124004669	Iron-sulfur protein interface; other site
349124004670	proximal heme binding site [chemical binding]; other site
349124004671	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
349124004672	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349124004673	catalytic loop [active]
349124004674	iron binding site [ion binding]; other site
349124004675	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
349124004676	L-aspartate oxidase; Provisional; Region: PRK06175
349124004677	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
349124004678	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
349124004679	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
349124004680	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349124004681	motif II; other site
349124004682	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
349124004683	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
349124004684	putative active site [active]
349124004685	putative PHP Thumb interface [polypeptide binding]; other site
349124004686	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
349124004687	generic binding surface II; other site
349124004688	generic binding surface I; other site
349124004689	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
349124004690	RNA/DNA hybrid binding site [nucleotide binding]; other site
349124004691	active site
349124004692	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
349124004693	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
349124004694	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
349124004695	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
349124004696	active site
349124004697	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
349124004698	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
349124004699	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349124004700	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349124004701	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349124004702	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349124004703	Surface antigen; Region: Bac_surface_Ag; pfam01103
349124004704	zinc metallopeptidase RseP; Provisional; Region: PRK10779
349124004705	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
349124004706	active site
349124004707	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
349124004708	protein binding site [polypeptide binding]; other site
349124004709	putative substrate binding region [chemical binding]; other site
349124004710	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
349124004711	protein binding site [polypeptide binding]; other site
349124004712	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
349124004713	putative substrate binding region [chemical binding]; other site
349124004714	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
349124004715	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
349124004716	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
349124004717	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
349124004718	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
349124004719	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
349124004720	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
349124004721	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
349124004722	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
349124004723	catalytic residue [active]
349124004724	putative FPP diphosphate  binding site; other site
349124004725	putative FPP binding hydrophobic cleft; other site
349124004726	dimer interface [polypeptide binding]; other site
349124004727	putative IPP diphosphate binding site; other site
349124004728	ribosome recycling factor; Reviewed; Region: frr; PRK00083
349124004729	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
349124004730	hinge region; other site
349124004731	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
349124004732	putative nucleotide binding site [chemical binding]; other site
349124004733	uridine monophosphate binding site [chemical binding]; other site
349124004734	homohexameric interface [polypeptide binding]; other site
349124004735	elongation factor Ts; Provisional; Region: tsf; PRK09377
349124004736	UBA/TS-N domain; Region: UBA; pfam00627
349124004737	Elongation factor TS; Region: EF_TS; pfam00889
349124004738	Elongation factor TS; Region: EF_TS; pfam00889
349124004739	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
349124004740	rRNA interaction site [nucleotide binding]; other site
349124004741	S8 interaction site; other site
349124004742	putative laminin-1 binding site; other site
349124004743	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
349124004744	active site
349124004745	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
349124004746	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349124004747	metal binding triad; other site
349124004748	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
349124004749	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349124004750	Zn2+ binding site [ion binding]; other site
349124004751	Mg2+ binding site [ion binding]; other site
349124004752	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
349124004753	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
349124004754	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
349124004755	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349124004756	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124004757	homodimer interface [polypeptide binding]; other site
349124004758	catalytic residue [active]
349124004759	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
349124004760	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
349124004761	trimer interface [polypeptide binding]; other site
349124004762	active site
349124004763	substrate binding site [chemical binding]; other site
349124004764	CoA binding site [chemical binding]; other site
349124004765	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
349124004766	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
349124004767	metal binding site [ion binding]; metal-binding site
349124004768	dimer interface [polypeptide binding]; other site
349124004769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
349124004770	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
349124004771	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
349124004772	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
349124004773	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
349124004774	dihydrodipicolinate reductase; Provisional; Region: PRK00048
349124004775	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
349124004776	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
349124004777	chaperone protein DnaJ; Provisional; Region: PRK10767
349124004778	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349124004779	HSP70 interaction site [polypeptide binding]; other site
349124004780	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
349124004781	substrate binding site [polypeptide binding]; other site
349124004782	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
349124004783	Zn binding sites [ion binding]; other site
349124004784	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
349124004785	dimer interface [polypeptide binding]; other site
349124004786	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
349124004787	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
349124004788	nucleotide binding site [chemical binding]; other site
349124004789	GrpE; Region: GrpE; pfam01025
349124004790	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
349124004791	dimer interface [polypeptide binding]; other site
349124004792	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
349124004793	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
349124004794	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
349124004795	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
349124004796	ATP-NAD kinase; Region: NAD_kinase; pfam01513
349124004797	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
349124004798	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
349124004799	Walker A/P-loop; other site
349124004800	ATP binding site [chemical binding]; other site
349124004801	Q-loop/lid; other site
349124004802	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
349124004803	ABC transporter signature motif; other site
349124004804	Walker B; other site
349124004805	D-loop; other site
349124004806	H-loop/switch region; other site
349124004807	ferric uptake regulator; Provisional; Region: fur; PRK09462
349124004808	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
349124004809	metal binding site 2 [ion binding]; metal-binding site
349124004810	putative DNA binding helix; other site
349124004811	metal binding site 1 [ion binding]; metal-binding site
349124004812	dimer interface [polypeptide binding]; other site
349124004813	structural Zn2+ binding site [ion binding]; other site
349124004814	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
349124004815	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
349124004816	RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658
349124004817	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
349124004818	putative coenzyme Q binding site [chemical binding]; other site
349124004819	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
349124004820	SmpB-tmRNA interface; other site
349124004821	High potential iron-sulfur protein; Region: HIPIP; pfam01355
349124004822	H-NS histone family; Region: Histone_HNS; pfam00816
349124004823	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
349124004824	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
349124004825	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
349124004826	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
349124004827	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
349124004828	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
349124004829	active site
349124004830	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
349124004831	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
349124004832	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
349124004833	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
349124004834	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
349124004835	Ligand binding site [chemical binding]; other site
349124004836	Electron transfer flavoprotein domain; Region: ETF; pfam01012
349124004837	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
349124004838	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
349124004839	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349124004840	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349124004841	Coenzyme A binding pocket [chemical binding]; other site
349124004842	acetylornithine deacetylase; Validated; Region: PRK06915
349124004843	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
349124004844	metal binding site [ion binding]; metal-binding site
349124004845	dimer interface [polypeptide binding]; other site
349124004846	Predicted acyl esterases [General function prediction only]; Region: COG2936
349124004847	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
349124004848	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
349124004849	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
349124004850	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349124004851	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
349124004852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124004853	S-adenosylmethionine binding site [chemical binding]; other site
349124004854	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
349124004855	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349124004856	ligand binding site [chemical binding]; other site
349124004857	flexible hinge region; other site
349124004858	Predicted membrane protein [Function unknown]; Region: COG4818
349124004859	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
349124004860	Chain length determinant protein; Region: Wzz; pfam02706
349124004861	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
349124004862	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
349124004863	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349124004864	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
349124004865	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
349124004866	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
349124004867	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
349124004868	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
349124004869	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
349124004870	active site
349124004871	dimer interface [polypeptide binding]; other site
349124004872	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
349124004873	Ligand Binding Site [chemical binding]; other site
349124004874	Molecular Tunnel; other site
349124004875	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
349124004876	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
349124004877	putative ADP-binding pocket [chemical binding]; other site
349124004878	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
349124004879	exosortase A; Region: exosortase_1; TIGR03109
349124004880	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
349124004881	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
349124004882	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
349124004883	Protein of unknown function, DUF482; Region: DUF482; pfam04339
349124004884	FemAB-related protein, PEP-CTERM system-associated; Region: pepcterm_femAB; TIGR03019
349124004885	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
349124004886	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
349124004887	putative active site [active]
349124004888	putative catalytic site [active]
349124004889	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
349124004890	AAA ATPase domain; Region: AAA_16; pfam13191
349124004891	uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016
349124004892	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
349124004893	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349124004894	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
349124004895	Chain length determinant protein; Region: Wzz; pfam02706
349124004896	PilZ domain; Region: PilZ; pfam07238
349124004897	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
349124004898	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
349124004899	hypothetical protein; Validated; Region: PRK08223
349124004900	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
349124004901	ATP binding site [chemical binding]; other site
349124004902	substrate interface [chemical binding]; other site
349124004903	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
349124004904	Protein export membrane protein; Region: SecD_SecF; cl14618
349124004905	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
349124004906	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
349124004907	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
349124004908	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124004909	binding surface
349124004910	TPR motif; other site
349124004911	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124004912	binding surface
349124004913	TPR motif; other site
349124004914	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124004915	binding surface
349124004916	TPR motif; other site
349124004917	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124004918	TPR motif; other site
349124004919	binding surface
349124004920	PEP-CTERM motif; Region: VPEP; pfam07589
349124004921	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
349124004922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124004923	active site
349124004924	phosphorylation site [posttranslational modification]
349124004925	intermolecular recognition site; other site
349124004926	dimerization interface [polypeptide binding]; other site
349124004927	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124004928	Walker A motif; other site
349124004929	ATP binding site [chemical binding]; other site
349124004930	Walker B motif; other site
349124004931	arginine finger; other site
349124004932	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349124004933	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
349124004934	GAF domain; Region: GAF; pfam01590
349124004935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124004936	ATP binding site [chemical binding]; other site
349124004937	Mg2+ binding site [ion binding]; other site
349124004938	G-X-G motif; other site
349124004939	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
349124004940	Bacterial sugar transferase; Region: Bac_transf; pfam02397
349124004941	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
349124004942	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
349124004943	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
349124004944	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
349124004945	NAD binding site [chemical binding]; other site
349124004946	homodimer interface [polypeptide binding]; other site
349124004947	active site
349124004948	substrate binding site [chemical binding]; other site
349124004949	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
349124004950	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
349124004951	Substrate binding site; other site
349124004952	Cupin domain; Region: Cupin_2; cl17218
349124004953	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
349124004954	PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353
349124004955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124004956	S-adenosylmethionine binding site [chemical binding]; other site
349124004957	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
349124004958	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
349124004959	VanZ like family; Region: VanZ; cl01971
349124004960	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
349124004961	short chain dehydrogenase; Provisional; Region: PRK07102
349124004962	NAD(P) binding site [chemical binding]; other site
349124004963	active site
349124004964	hypothetical protein; Provisional; Region: PRK07233
349124004965	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349124004966	Predicted membrane protein [Function unknown]; Region: COG2246
349124004967	GtrA-like protein; Region: GtrA; pfam04138
349124004968	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
349124004969	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
349124004970	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
349124004971	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
349124004972	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
349124004973	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
349124004974	putative active site [active]
349124004975	O-Antigen ligase; Region: Wzy_C; cl04850
349124004976	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
349124004977	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
349124004978	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
349124004979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124004980	Walker A/P-loop; other site
349124004981	ATP binding site [chemical binding]; other site
349124004982	Q-loop/lid; other site
349124004983	ABC transporter signature motif; other site
349124004984	Walker B; other site
349124004985	D-loop; other site
349124004986	H-loop/switch region; other site
349124004987	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
349124004988	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349124004989	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
349124004990	acyl-activating enzyme (AAE) consensus motif; other site
349124004991	acyl-activating enzyme (AAE) consensus motif; other site
349124004992	putative AMP binding site [chemical binding]; other site
349124004993	putative active site [active]
349124004994	putative CoA binding site [chemical binding]; other site
349124004995	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
349124004996	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
349124004997	dimer interface [polypeptide binding]; other site
349124004998	active site
349124004999	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349124005000	catalytic residues [active]
349124005001	substrate binding site [chemical binding]; other site
349124005002	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
349124005003	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
349124005004	active site
349124005005	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
349124005006	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349124005007	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
349124005008	catalytic residue [active]
349124005009	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
349124005010	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
349124005011	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
349124005012	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
349124005013	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349124005014	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
349124005015	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349124005016	acyl carrier protein; Provisional; Region: PRK07639
349124005017	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349124005018	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
349124005019	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
349124005020	Low molecular weight phosphatase family; Region: LMWPc; cl00105
349124005021	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
349124005022	active site
349124005023	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
349124005024	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
349124005025	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124005026	Walker A motif; other site
349124005027	ATP binding site [chemical binding]; other site
349124005028	Walker B motif; other site
349124005029	arginine finger; other site
349124005030	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
349124005031	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124005032	PAS fold; Region: PAS_3; pfam08447
349124005033	putative active site [active]
349124005034	heme pocket [chemical binding]; other site
349124005035	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124005036	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124005037	metal binding site [ion binding]; metal-binding site
349124005038	active site
349124005039	I-site; other site
349124005040	glutamine synthetase; Provisional; Region: glnA; PRK09469
349124005041	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
349124005042	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
349124005043	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
349124005044	IHF - DNA interface [nucleotide binding]; other site
349124005045	IHF dimer interface [polypeptide binding]; other site
349124005046	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
349124005047	RNA/DNA hybrid binding site [nucleotide binding]; other site
349124005048	active site
349124005049	Methyltransferase domain; Region: Methyltransf_11; pfam08241
349124005050	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
349124005051	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349124005052	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349124005053	catalytic residue [active]
349124005054	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349124005055	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349124005056	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
349124005057	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349124005058	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
349124005059	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
349124005060	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
349124005061	Switch I; other site
349124005062	Switch II; other site
349124005063	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
349124005064	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
349124005065	heat shock protein 90; Provisional; Region: PRK05218
349124005066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124005067	ATP binding site [chemical binding]; other site
349124005068	Mg2+ binding site [ion binding]; other site
349124005069	G-X-G motif; other site
349124005070	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
349124005071	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
349124005072	DNA binding site [nucleotide binding]
349124005073	active site
349124005074	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
349124005075	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
349124005076	PYR/PP interface [polypeptide binding]; other site
349124005077	dimer interface [polypeptide binding]; other site
349124005078	TPP binding site [chemical binding]; other site
349124005079	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
349124005080	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
349124005081	TPP-binding site [chemical binding]; other site
349124005082	dimer interface [polypeptide binding]; other site
349124005083	methionine sulfoxide reductase B; Provisional; Region: PRK00222
349124005084	SelR domain; Region: SelR; pfam01641
349124005085	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
349124005086	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
349124005087	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
349124005088	NAD-dependent deacetylase; Provisional; Region: PRK00481
349124005089	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
349124005090	NAD+ binding site [chemical binding]; other site
349124005091	substrate binding site [chemical binding]; other site
349124005092	Zn binding site [ion binding]; other site
349124005093	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
349124005094	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
349124005095	phosphoserine phosphatase SerB; Region: serB; TIGR00338
349124005096	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349124005097	motif II; other site
349124005098	Surface antigen; Region: Bac_surface_Ag; pfam01103
349124005099	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
349124005100	UbiA prenyltransferase family; Region: UbiA; pfam01040
349124005101	PUCC protein; Region: PUCC; pfam03209
349124005102	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
349124005103	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224
349124005104	subunit interface [polypeptide binding]; other site
349124005105	Heme binding sites [chemical binding]; other site
349124005106	photosynthetic reaction center subunit M; Provisional; Region: PRK14504
349124005107	pheophytin binding site; other site
349124005108	chlorophyll binding site; other site
349124005109	quinone binding site; other site
349124005110	Fe binding site [ion binding]; other site
349124005111	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
349124005112	subunit M interface; other site
349124005113	subunit H interface; other site
349124005114	quinone binding site; other site
349124005115	bacteriopheophytin binding site; other site
349124005116	bacteriochlorophyll binding site; other site
349124005117	cytochrome C subunit interface; other site
349124005118	Fe binding site [ion binding]; other site
349124005119	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
349124005120	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
349124005121	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
349124005122	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
349124005123	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
349124005124	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
349124005125	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
349124005126	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
349124005127	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
349124005128	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
349124005129	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
349124005130	putative NAD(P) binding site [chemical binding]; other site
349124005131	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124005132	S-adenosylmethionine binding site [chemical binding]; other site
349124005133	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
349124005134	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
349124005135	substrate binding pocket [chemical binding]; other site
349124005136	chain length determination region; other site
349124005137	substrate-Mg2+ binding site; other site
349124005138	catalytic residues [active]
349124005139	aspartate-rich region 1; other site
349124005140	active site lid residues [active]
349124005141	aspartate-rich region 2; other site
349124005142	phytoene desaturase; Region: crtI_fam; TIGR02734
349124005143	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
349124005144	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
349124005145	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349124005146	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349124005147	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
349124005148	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
349124005149	active site
349124005150	dimer interface [polypeptide binding]; other site
349124005151	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
349124005152	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
349124005153	active site
349124005154	FMN binding site [chemical binding]; other site
349124005155	substrate binding site [chemical binding]; other site
349124005156	3Fe-4S cluster binding site [ion binding]; other site
349124005157	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
349124005158	domain interface; other site
349124005159	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
349124005160	active site lid residues [active]
349124005161	substrate binding pocket [chemical binding]; other site
349124005162	catalytic residues [active]
349124005163	substrate-Mg2+ binding site; other site
349124005164	aspartate-rich region 1; other site
349124005165	aspartate-rich region 2; other site
349124005166	phytoene desaturase; Region: crtI_fam; TIGR02734
349124005167	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349124005168	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
349124005169	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
349124005170	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
349124005171	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
349124005172	metal ion-dependent adhesion site (MIDAS); other site
349124005173	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
349124005174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124005175	Walker A motif; other site
349124005176	ATP binding site [chemical binding]; other site
349124005177	Walker B motif; other site
349124005178	arginine finger; other site
349124005179	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
349124005180	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
349124005181	active site
349124005182	metal binding site [ion binding]; metal-binding site
349124005183	nudix motif; other site
349124005184	High potential iron-sulfur protein; Region: HIPIP; pfam01355
349124005185	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
349124005186	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
349124005187	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124005188	FeS/SAM binding site; other site
349124005189	V4R domain; Region: V4R; cl15268
349124005190	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349124005191	Protein of unknown function (DUF3623); Region: DUF3623; pfam12291
349124005192	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
349124005193	Bacterial PH domain; Region: DUF304; pfam03703
349124005194	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
349124005195	subunit C interaction residues; other site
349124005196	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
349124005197	subunit M interaction residues [polypeptide binding]; other site
349124005198	subunit L interaction residues [polypeptide binding]; other site
349124005199	putative proton transfer pathway, P1; other site
349124005200	putative proton transfer pathway, P2; other site
349124005201	PUCC protein; Region: PUCC; pfam03209
349124005202	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
349124005203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349124005204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124005205	S-adenosylmethionine binding site [chemical binding]; other site
349124005206	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
349124005207	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
349124005208	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
349124005209	P-loop; other site
349124005210	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
349124005211	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
349124005212	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
349124005213	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
349124005214	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
349124005215	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
349124005216	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
349124005217	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
349124005218	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
349124005219	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
349124005220	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
349124005221	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349124005222	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
349124005223	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
349124005224	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
349124005225	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
349124005226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124005227	catalytic residue [active]
349124005228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
349124005229	PAS fold; Region: PAS_4; pfam08448
349124005230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124005231	putative active site [active]
349124005232	heme pocket [chemical binding]; other site
349124005233	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124005234	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124005235	dimer interface [polypeptide binding]; other site
349124005236	phosphorylation site [posttranslational modification]
349124005237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124005238	ATP binding site [chemical binding]; other site
349124005239	Mg2+ binding site [ion binding]; other site
349124005240	G-X-G motif; other site
349124005241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124005242	Response regulator receiver domain; Region: Response_reg; pfam00072
349124005243	active site
349124005244	phosphorylation site [posttranslational modification]
349124005245	intermolecular recognition site; other site
349124005246	dimerization interface [polypeptide binding]; other site
349124005247	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
349124005248	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
349124005249	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
349124005250	NAD(P) binding site [chemical binding]; other site
349124005251	active site
349124005252	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
349124005253	Transcriptional regulator [Transcription]; Region: LysR; COG0583
349124005254	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349124005255	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
349124005256	dimerization interface [polypeptide binding]; other site
349124005257	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
349124005258	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349124005259	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349124005260	ABC transporter; Region: ABC_tran_2; pfam12848
349124005261	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349124005262	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
349124005263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124005264	Walker A motif; other site
349124005265	ATP binding site [chemical binding]; other site
349124005266	Walker B motif; other site
349124005267	carbon storage regulator; Provisional; Region: PRK01712
349124005268	aspartate kinase; Reviewed; Region: PRK06635
349124005269	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
349124005270	putative nucleotide binding site [chemical binding]; other site
349124005271	putative catalytic residues [active]
349124005272	putative Mg ion binding site [ion binding]; other site
349124005273	putative aspartate binding site [chemical binding]; other site
349124005274	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
349124005275	putative allosteric regulatory site; other site
349124005276	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
349124005277	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
349124005278	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
349124005279	motif 1; other site
349124005280	active site
349124005281	motif 2; other site
349124005282	motif 3; other site
349124005283	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
349124005284	recombination regulator RecX; Reviewed; Region: recX; PRK00117
349124005285	recombinase A; Provisional; Region: recA; PRK09354
349124005286	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
349124005287	hexamer interface [polypeptide binding]; other site
349124005288	Walker A motif; other site
349124005289	ATP binding site [chemical binding]; other site
349124005290	Walker B motif; other site
349124005291	Competence-damaged protein; Region: CinA; pfam02464
349124005292	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
349124005293	MutS domain I; Region: MutS_I; pfam01624
349124005294	MutS domain II; Region: MutS_II; pfam05188
349124005295	MutS domain III; Region: MutS_III; pfam05192
349124005296	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
349124005297	Walker A/P-loop; other site
349124005298	ATP binding site [chemical binding]; other site
349124005299	Q-loop/lid; other site
349124005300	ABC transporter signature motif; other site
349124005301	Walker B; other site
349124005302	D-loop; other site
349124005303	H-loop/switch region; other site
349124005304	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
349124005305	4Fe-4S binding domain; Region: Fer4; cl02805
349124005306	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
349124005307	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
349124005308	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
349124005309	active site
349124005310	DNA binding site [nucleotide binding]
349124005311	Int/Topo IB signature motif; other site
349124005312	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
349124005313	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
349124005314	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
349124005315	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
349124005316	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
349124005317	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
349124005318	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
349124005319	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
349124005320	nucleophilic elbow; other site
349124005321	catalytic triad; other site
349124005322	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
349124005323	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349124005324	Protein required for attachment to host cells; Region: Host_attach; pfam10116
349124005325	endonuclease IV; Provisional; Region: PRK01060
349124005326	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
349124005327	AP (apurinic/apyrimidinic) site pocket; other site
349124005328	DNA interaction; other site
349124005329	Metal-binding active site; metal-binding site
349124005330	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
349124005331	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
349124005332	C factor cell-cell signaling protein; Provisional; Region: PRK09009
349124005333	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
349124005334	NADP binding site [chemical binding]; other site
349124005335	homodimer interface [polypeptide binding]; other site
349124005336	active site
349124005337	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
349124005338	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349124005339	sequence-specific DNA binding site [nucleotide binding]; other site
349124005340	salt bridge; other site
349124005341	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
349124005342	active site
349124005343	substrate-binding site [chemical binding]; other site
349124005344	metal-binding site [ion binding]
349124005345	GTP binding site [chemical binding]; other site
349124005346	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
349124005347	FAD binding site [chemical binding]; other site
349124005348	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
349124005349	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
349124005350	homotetramer interface [polypeptide binding]; other site
349124005351	ligand binding site [chemical binding]; other site
349124005352	catalytic site [active]
349124005353	NAD binding site [chemical binding]; other site
349124005354	S-adenosylmethionine synthetase; Validated; Region: PRK05250
349124005355	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
349124005356	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
349124005357	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
349124005358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124005359	S-adenosylmethionine binding site [chemical binding]; other site
349124005360	Methyltransferase domain; Region: Methyltransf_23; pfam13489
349124005361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124005362	S-adenosylmethionine binding site [chemical binding]; other site
349124005363	DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594
349124005364	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
349124005365	nucleoside/Zn binding site; other site
349124005366	dimer interface [polypeptide binding]; other site
349124005367	catalytic motif [active]
349124005368	GMP synthase; Reviewed; Region: guaA; PRK00074
349124005369	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
349124005370	AMP/PPi binding site [chemical binding]; other site
349124005371	candidate oxyanion hole; other site
349124005372	catalytic triad [active]
349124005373	potential glutamine specificity residues [chemical binding]; other site
349124005374	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
349124005375	ATP Binding subdomain [chemical binding]; other site
349124005376	Ligand Binding sites [chemical binding]; other site
349124005377	Dimerization subdomain; other site
349124005378	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
349124005379	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
349124005380	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
349124005381	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
349124005382	active site
349124005383	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
349124005384	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
349124005385	generic binding surface II; other site
349124005386	generic binding surface I; other site
349124005387	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
349124005388	Peptidase family M23; Region: Peptidase_M23; pfam01551
349124005389	putative acyltransferase; Provisional; Region: PRK05790
349124005390	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
349124005391	dimer interface [polypeptide binding]; other site
349124005392	active site
349124005393	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
349124005394	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
349124005395	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
349124005396	putative dimer interface [polypeptide binding]; other site
349124005397	N-terminal domain interface [polypeptide binding]; other site
349124005398	putative substrate binding pocket (H-site) [chemical binding]; other site
349124005399	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
349124005400	catalytic triad [active]
349124005401	dimer interface [polypeptide binding]; other site
349124005402	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349124005403	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
349124005404	SpoVR family protein; Provisional; Region: PRK11767
349124005405	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
349124005406	hypothetical protein; Provisional; Region: PRK05325
349124005407	PrkA family serine protein kinase; Provisional; Region: PRK15455
349124005408	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124005409	Walker A motif; other site
349124005410	ATP binding site [chemical binding]; other site
349124005411	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
349124005412	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
349124005413	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
349124005414	dimer interface [polypeptide binding]; other site
349124005415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124005416	catalytic residue [active]
349124005417	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
349124005418	Protein export membrane protein; Region: SecD_SecF; pfam02355
349124005419	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
349124005420	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
349124005421	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
349124005422	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
349124005423	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
349124005424	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
349124005425	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
349124005426	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
349124005427	active site clefts [active]
349124005428	zinc binding site [ion binding]; other site
349124005429	dimer interface [polypeptide binding]; other site
349124005430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
349124005431	MOSC domain; Region: MOSC; pfam03473
349124005432	RNase_H superfamily; Region: RNase_H_2; pfam13482
349124005433	active site
349124005434	substrate binding site [chemical binding]; other site
349124005435	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
349124005436	catalytic residues [active]
349124005437	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
349124005438	putative active site pocket [active]
349124005439	dimerization interface [polypeptide binding]; other site
349124005440	putative catalytic residue [active]
349124005441	PAS fold; Region: PAS_4; pfam08448
349124005442	PAS domain S-box; Region: sensory_box; TIGR00229
349124005443	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124005444	putative active site [active]
349124005445	heme pocket [chemical binding]; other site
349124005446	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124005447	metal binding site [ion binding]; metal-binding site
349124005448	active site
349124005449	I-site; other site
349124005450	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124005451	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
349124005452	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349124005453	ATP binding site [chemical binding]; other site
349124005454	putative Mg++ binding site [ion binding]; other site
349124005455	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349124005456	nucleotide binding region [chemical binding]; other site
349124005457	ATP-binding site [chemical binding]; other site
349124005458	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
349124005459	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
349124005460	Part of AAA domain; Region: AAA_19; pfam13245
349124005461	Family description; Region: UvrD_C_2; pfam13538
349124005462	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
349124005463	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
349124005464	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
349124005465	active site
349124005466	metal binding site [ion binding]; metal-binding site
349124005467	AAA domain; Region: AAA_23; pfam13476
349124005468	P-loop containing region of AAA domain; Region: AAA_29; cl17516
349124005469	Protein of unknown function (DUF615); Region: DUF615; cl01147
349124005470	SprT homologues; Region: SprT; cl01182
349124005471	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
349124005472	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
349124005473	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
349124005474	dimerization interface [polypeptide binding]; other site
349124005475	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124005476	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124005477	dimer interface [polypeptide binding]; other site
349124005478	putative CheW interface [polypeptide binding]; other site
349124005479	PAS domain S-box; Region: sensory_box; TIGR00229
349124005480	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124005481	PAS domain; Region: PAS_9; pfam13426
349124005482	putative active site [active]
349124005483	heme pocket [chemical binding]; other site
349124005484	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124005485	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124005486	metal binding site [ion binding]; metal-binding site
349124005487	active site
349124005488	I-site; other site
349124005489	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124005490	CheB methylesterase; Region: CheB_methylest; pfam01339
349124005491	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
349124005492	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124005493	S-adenosylmethionine binding site [chemical binding]; other site
349124005494	PAS domain; Region: PAS_10; pfam13596
349124005495	AAA domain; Region: AAA_32; pfam13654
349124005496	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
349124005497	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124005498	Ligand Binding Site [chemical binding]; other site
349124005499	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
349124005500	MgtE intracellular N domain; Region: MgtE_N; pfam03448
349124005501	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
349124005502	Divalent cation transporter; Region: MgtE; pfam01769
349124005503	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
349124005504	glutamate--cysteine ligase; Region: PLN02611
349124005505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
349124005506	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
349124005507	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
349124005508	AAA domain; Region: AAA_33; pfam13671
349124005509	active site
349124005510	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
349124005511	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
349124005512	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349124005513	dimer interface [polypeptide binding]; other site
349124005514	putative PBP binding regions; other site
349124005515	ABC-ATPase subunit  interface; other site
349124005516	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
349124005517	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124005518	Walker A/P-loop; other site
349124005519	ATP binding site [chemical binding]; other site
349124005520	Q-loop/lid; other site
349124005521	ABC transporter signature motif; other site
349124005522	Walker B; other site
349124005523	D-loop; other site
349124005524	H-loop/switch region; other site
349124005525	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
349124005526	metal binding site 2 [ion binding]; metal-binding site
349124005527	putative DNA binding helix; other site
349124005528	metal binding site 1 [ion binding]; metal-binding site
349124005529	dimer interface [polypeptide binding]; other site
349124005530	structural Zn2+ binding site [ion binding]; other site
349124005531	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
349124005532	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
349124005533	metal binding site [ion binding]; metal-binding site
349124005534	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
349124005535	Glycoprotease family; Region: Peptidase_M22; pfam00814
349124005536	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
349124005537	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349124005538	Coenzyme A binding pocket [chemical binding]; other site
349124005539	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
349124005540	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349124005541	inhibitor-cofactor binding pocket; inhibition site
349124005542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124005543	catalytic residue [active]
349124005544	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
349124005545	Dynamin family; Region: Dynamin_N; pfam00350
349124005546	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
349124005547	G1 box; other site
349124005548	GTP/Mg2+ binding site [chemical binding]; other site
349124005549	G2 box; other site
349124005550	Switch I region; other site
349124005551	G3 box; other site
349124005552	Switch II region; other site
349124005553	G4 box; other site
349124005554	G5 box; other site
349124005555	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
349124005556	G1 box; other site
349124005557	GTP/Mg2+ binding site [chemical binding]; other site
349124005558	G2 box; other site
349124005559	Switch I region; other site
349124005560	G3 box; other site
349124005561	Switch II region; other site
349124005562	G4 box; other site
349124005563	G5 box; other site
349124005564	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
349124005565	generic binding surface II; other site
349124005566	generic binding surface I; other site
349124005567	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
349124005568	putative active site [active]
349124005569	putative catalytic site [active]
349124005570	putative Mg binding site IVb [ion binding]; other site
349124005571	putative phosphate binding site [ion binding]; other site
349124005572	putative DNA binding site [nucleotide binding]; other site
349124005573	putative Mg binding site IVa [ion binding]; other site
349124005574	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349124005575	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349124005576	HlyD family secretion protein; Region: HlyD_3; pfam13437
349124005577	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
349124005578	HD domain; Region: HD_4; pfam13328
349124005579	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
349124005580	synthetase active site [active]
349124005581	NTP binding site [chemical binding]; other site
349124005582	metal binding site [ion binding]; metal-binding site
349124005583	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
349124005584	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
349124005585	LexA repressor; Validated; Region: PRK00215
349124005586	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
349124005587	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
349124005588	Catalytic site [active]
349124005589	Uncharacterized conserved protein [Function unknown]; Region: COG4544
349124005590	DNA Polymerase Y-family; Region: PolY_like; cd03468
349124005591	DNA binding site [nucleotide binding]
349124005592	Isochorismatase family; Region: Isochorismatase; pfam00857
349124005593	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
349124005594	catalytic triad [active]
349124005595	metal binding site [ion binding]; metal-binding site
349124005596	conserved cis-peptide bond; other site
349124005597	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
349124005598	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
349124005599	RNase E interface [polypeptide binding]; other site
349124005600	trimer interface [polypeptide binding]; other site
349124005601	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
349124005602	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
349124005603	RNase E interface [polypeptide binding]; other site
349124005604	trimer interface [polypeptide binding]; other site
349124005605	active site
349124005606	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
349124005607	putative nucleic acid binding region [nucleotide binding]; other site
349124005608	G-X-X-G motif; other site
349124005609	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
349124005610	RNA binding site [nucleotide binding]; other site
349124005611	domain interface; other site
349124005612	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
349124005613	16S/18S rRNA binding site [nucleotide binding]; other site
349124005614	S13e-L30e interaction site [polypeptide binding]; other site
349124005615	25S rRNA binding site [nucleotide binding]; other site
349124005616	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
349124005617	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
349124005618	RNA binding site [nucleotide binding]; other site
349124005619	active site
349124005620	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
349124005621	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
349124005622	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
349124005623	translation initiation factor IF-2; Region: IF-2; TIGR00487
349124005624	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
349124005625	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
349124005626	G1 box; other site
349124005627	putative GEF interaction site [polypeptide binding]; other site
349124005628	GTP/Mg2+ binding site [chemical binding]; other site
349124005629	Switch I region; other site
349124005630	G2 box; other site
349124005631	G3 box; other site
349124005632	Switch II region; other site
349124005633	G4 box; other site
349124005634	G5 box; other site
349124005635	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
349124005636	Translation-initiation factor 2; Region: IF-2; pfam11987
349124005637	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
349124005638	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
349124005639	NusA N-terminal domain; Region: NusA_N; pfam08529
349124005640	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
349124005641	RNA binding site [nucleotide binding]; other site
349124005642	homodimer interface [polypeptide binding]; other site
349124005643	NusA-like KH domain; Region: KH_5; pfam13184
349124005644	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
349124005645	G-X-X-G motif; other site
349124005646	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
349124005647	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
349124005648	ribosome maturation protein RimP; Reviewed; Region: PRK00092
349124005649	Sm and related proteins; Region: Sm_like; cl00259
349124005650	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
349124005651	putative oligomer interface [polypeptide binding]; other site
349124005652	putative RNA binding site [nucleotide binding]; other site
349124005653	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
349124005654	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349124005655	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
349124005656	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349124005657	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
349124005658	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
349124005659	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349124005660	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
349124005661	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
349124005662	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
349124005663	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
349124005664	4Fe-4S binding domain; Region: Fer4; pfam00037
349124005665	4Fe-4S binding domain; Region: Fer4; pfam00037
349124005666	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
349124005667	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
349124005668	NADH dehydrogenase subunit G; Validated; Region: PRK09129
349124005669	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349124005670	catalytic loop [active]
349124005671	iron binding site [ion binding]; other site
349124005672	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
349124005673	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349124005674	molybdopterin cofactor binding site; other site
349124005675	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
349124005676	molybdopterin cofactor binding site; other site
349124005677	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
349124005678	SLBB domain; Region: SLBB; pfam10531
349124005679	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
349124005680	NADH dehydrogenase subunit E; Validated; Region: PRK07539
349124005681	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
349124005682	putative dimer interface [polypeptide binding]; other site
349124005683	[2Fe-2S] cluster binding site [ion binding]; other site
349124005684	NADH dehydrogenase subunit D; Validated; Region: PRK06075
349124005685	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
349124005686	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
349124005687	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
349124005688	NADH dehydrogenase subunit B; Validated; Region: PRK06411
349124005689	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
349124005690	Preprotein translocase SecG subunit; Region: SecG; pfam03840
349124005691	triosephosphate isomerase; Provisional; Region: PRK14567
349124005692	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
349124005693	substrate binding site [chemical binding]; other site
349124005694	dimer interface [polypeptide binding]; other site
349124005695	catalytic triad [active]
349124005696	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
349124005697	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
349124005698	active site
349124005699	substrate binding site [chemical binding]; other site
349124005700	metal binding site [ion binding]; metal-binding site
349124005701	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
349124005702	dihydropteroate synthase; Region: DHPS; TIGR01496
349124005703	substrate binding pocket [chemical binding]; other site
349124005704	dimer interface [polypeptide binding]; other site
349124005705	inhibitor binding site; inhibition site
349124005706	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
349124005707	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124005708	Walker A motif; other site
349124005709	ATP binding site [chemical binding]; other site
349124005710	Walker B motif; other site
349124005711	arginine finger; other site
349124005712	Peptidase family M41; Region: Peptidase_M41; pfam01434
349124005713	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
349124005714	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124005715	S-adenosylmethionine binding site [chemical binding]; other site
349124005716	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
349124005717	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
349124005718	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
349124005719	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
349124005720	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
349124005721	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
349124005722	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349124005723	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349124005724	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
349124005725	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349124005726	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349124005727	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
349124005728	IMP binding site; other site
349124005729	dimer interface [polypeptide binding]; other site
349124005730	interdomain contacts; other site
349124005731	partial ornithine binding site; other site
349124005732	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
349124005733	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
349124005734	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
349124005735	catalytic site [active]
349124005736	subunit interface [polypeptide binding]; other site
349124005737	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
349124005738	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
349124005739	Active Sites [active]
349124005740	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
349124005741	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
349124005742	Walker A/P-loop; other site
349124005743	ATP binding site [chemical binding]; other site
349124005744	Q-loop/lid; other site
349124005745	ABC transporter signature motif; other site
349124005746	Walker B; other site
349124005747	D-loop; other site
349124005748	H-loop/switch region; other site
349124005749	inner membrane transport permease; Provisional; Region: PRK15066
349124005750	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
349124005751	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
349124005752	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
349124005753	active site
349124005754	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
349124005755	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
349124005756	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
349124005757	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
349124005758	active site residues [active]
349124005759	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
349124005760	dimer interface [polypeptide binding]; other site
349124005761	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
349124005762	adenylate kinase; Reviewed; Region: adk; PRK00279
349124005763	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
349124005764	AMP-binding site [chemical binding]; other site
349124005765	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
349124005766	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
349124005767	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
349124005768	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
349124005769	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
349124005770	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
349124005771	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
349124005772	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
349124005773	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
349124005774	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
349124005775	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
349124005776	Trp docking motif [polypeptide binding]; other site
349124005777	active site
349124005778	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
349124005779	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
349124005780	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
349124005781	dimer interface [polypeptide binding]; other site
349124005782	motif 1; other site
349124005783	active site
349124005784	motif 2; other site
349124005785	motif 3; other site
349124005786	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
349124005787	anticodon binding site; other site
349124005788	Helix-turn-helix domain; Region: HTH_25; pfam13413
349124005789	TPR repeat; Region: TPR_11; pfam13414
349124005790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124005791	TPR motif; other site
349124005792	binding surface
349124005793	TPR repeat; Region: TPR_11; pfam13414
349124005794	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
349124005795	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124005796	FeS/SAM binding site; other site
349124005797	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
349124005798	active site
349124005799	multimer interface [polypeptide binding]; other site
349124005800	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
349124005801	serine O-acetyltransferase; Region: cysE; TIGR01172
349124005802	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
349124005803	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
349124005804	trimer interface [polypeptide binding]; other site
349124005805	active site
349124005806	substrate binding site [chemical binding]; other site
349124005807	CoA binding site [chemical binding]; other site
349124005808	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
349124005809	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
349124005810	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349124005811	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
349124005812	active site
349124005813	dimerization interface [polypeptide binding]; other site
349124005814	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
349124005815	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
349124005816	homodimer interface [polypeptide binding]; other site
349124005817	substrate-cofactor binding pocket; other site
349124005818	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124005819	catalytic residue [active]
349124005820	amidophosphoribosyltransferase; Provisional; Region: PRK09246
349124005821	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
349124005822	active site
349124005823	tetramer interface [polypeptide binding]; other site
349124005824	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349124005825	active site
349124005826	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
349124005827	Colicin V production protein; Region: Colicin_V; pfam02674
349124005828	Sporulation related domain; Region: SPOR; pfam05036
349124005829	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
349124005830	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
349124005831	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
349124005832	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
349124005833	substrate binding site [chemical binding]; other site
349124005834	active site
349124005835	catalytic residues [active]
349124005836	heterodimer interface [polypeptide binding]; other site
349124005837	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
349124005838	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
349124005839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124005840	catalytic residue [active]
349124005841	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
349124005842	active site
349124005843	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
349124005844	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
349124005845	dimerization interface 3.5A [polypeptide binding]; other site
349124005846	active site
349124005847	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
349124005848	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
349124005849	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
349124005850	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
349124005851	sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273
349124005852	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
349124005853	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
349124005854	tartrate dehydrogenase; Region: TTC; TIGR02089
349124005855	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
349124005856	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
349124005857	substrate binding site [chemical binding]; other site
349124005858	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
349124005859	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
349124005860	substrate binding site [chemical binding]; other site
349124005861	ligand binding site [chemical binding]; other site
349124005862	MFS_1 like family; Region: MFS_1_like; pfam12832
349124005863	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
349124005864	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
349124005865	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
349124005866	Tetramer interface [polypeptide binding]; other site
349124005867	active site
349124005868	FMN-binding site [chemical binding]; other site
349124005869	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
349124005870	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
349124005871	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
349124005872	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
349124005873	Ligand Binding Site [chemical binding]; other site
349124005874	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
349124005875	hydroxyglutarate oxidase; Provisional; Region: PRK11728
349124005876	PAS fold; Region: PAS; pfam00989
349124005877	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124005878	putative active site [active]
349124005879	heme pocket [chemical binding]; other site
349124005880	4-coumarate--CoA ligase, photoactive yellow protein activation family; Region: 4_coum_CoA_lig; TIGR02372
349124005881	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
349124005882	active site
349124005883	CoA binding site [chemical binding]; other site
349124005884	AMP binding site [chemical binding]; other site
349124005885	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
349124005886	active sites [active]
349124005887	tetramer interface [polypeptide binding]; other site
349124005888	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
349124005889	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
349124005890	Type II transport protein GspH; Region: GspH; pfam12019
349124005891	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
349124005892	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
349124005893	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
349124005894	Cortical protein marker for cell polarity; Region: Rax2; pfam12768
349124005895	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
349124005896	putative active site [active]
349124005897	TPR repeat; Region: TPR_11; pfam13414
349124005898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124005899	TPR motif; other site
349124005900	LPP20 lipoprotein; Region: LPP20; pfam02169
349124005901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
349124005902	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
349124005903	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201
349124005904	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
349124005905	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
349124005906	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
349124005907	lipoprotein signal peptidase; Provisional; Region: PRK14787
349124005908	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
349124005909	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349124005910	active site
349124005911	HIGH motif; other site
349124005912	nucleotide binding site [chemical binding]; other site
349124005913	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
349124005914	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
349124005915	active site
349124005916	KMSKS motif; other site
349124005917	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
349124005918	tRNA binding surface [nucleotide binding]; other site
349124005919	anticodon binding site; other site
349124005920	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
349124005921	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
349124005922	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
349124005923	active site
349124005924	Riboflavin kinase; Region: Flavokinase; smart00904
349124005925	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
349124005926	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
349124005927	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
349124005928	Permease; Region: Permease; pfam02405
349124005929	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
349124005930	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124005931	Walker A/P-loop; other site
349124005932	ATP binding site [chemical binding]; other site
349124005933	Q-loop/lid; other site
349124005934	ABC transporter signature motif; other site
349124005935	Walker B; other site
349124005936	D-loop; other site
349124005937	H-loop/switch region; other site
349124005938	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
349124005939	mce related protein; Region: MCE; pfam02470
349124005940	Protein of unknown function (DUF330); Region: DUF330; cl01135
349124005941	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
349124005942	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349124005943	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349124005944	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349124005945	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
349124005946	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
349124005947	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
349124005948	gamma-glutamyl kinase; Provisional; Region: PRK05429
349124005949	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
349124005950	nucleotide binding site [chemical binding]; other site
349124005951	homotetrameric interface [polypeptide binding]; other site
349124005952	putative phosphate binding site [ion binding]; other site
349124005953	putative allosteric binding site; other site
349124005954	PUA domain; Region: PUA; pfam01472
349124005955	GTPase CgtA; Reviewed; Region: obgE; PRK12299
349124005956	GTP1/OBG; Region: GTP1_OBG; pfam01018
349124005957	Obg GTPase; Region: Obg; cd01898
349124005958	G1 box; other site
349124005959	GTP/Mg2+ binding site [chemical binding]; other site
349124005960	Switch I region; other site
349124005961	G2 box; other site
349124005962	G3 box; other site
349124005963	Switch II region; other site
349124005964	G4 box; other site
349124005965	G5 box; other site
349124005966	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
349124005967	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
349124005968	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
349124005969	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
349124005970	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
349124005971	substrate binding pocket [chemical binding]; other site
349124005972	chain length determination region; other site
349124005973	substrate-Mg2+ binding site; other site
349124005974	catalytic residues [active]
349124005975	aspartate-rich region 1; other site
349124005976	active site lid residues [active]
349124005977	aspartate-rich region 2; other site
349124005978	BCCT family transporter; Region: BCCT; pfam02028
349124005979	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
349124005980	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
349124005981	homotrimer interface [polypeptide binding]; other site
349124005982	Walker A motif; other site
349124005983	GTP binding site [chemical binding]; other site
349124005984	Walker B motif; other site
349124005985	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
349124005986	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
349124005987	putative dimer interface [polypeptide binding]; other site
349124005988	active site pocket [active]
349124005989	putative cataytic base [active]
349124005990	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
349124005991	catalytic core [active]
349124005992	cobalamin synthase; Reviewed; Region: cobS; PRK00235
349124005993	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
349124005994	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
349124005995	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349124005996	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124005997	homodimer interface [polypeptide binding]; other site
349124005998	catalytic residue [active]
349124005999	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
349124006000	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
349124006001	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
349124006002	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
349124006003	inhibitor-cofactor binding pocket; inhibition site
349124006004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124006005	catalytic residue [active]
349124006006	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
349124006007	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
349124006008	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349124006009	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
349124006010	Soluble P-type ATPase [General function prediction only]; Region: COG4087
349124006011	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
349124006012	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124006013	Ligand Binding Site [chemical binding]; other site
349124006014	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124006015	Ligand Binding Site [chemical binding]; other site
349124006016	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
349124006017	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
349124006018	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
349124006019	TrkA-N domain; Region: TrkA_N; pfam02254
349124006020	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
349124006021	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
349124006022	ligand binding site; other site
349124006023	oligomer interface; other site
349124006024	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
349124006025	dimer interface [polypeptide binding]; other site
349124006026	N-terminal domain interface [polypeptide binding]; other site
349124006027	sulfate 1 binding site; other site
349124006028	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
349124006029	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
349124006030	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349124006031	Zn2+ binding site [ion binding]; other site
349124006032	Mg2+ binding site [ion binding]; other site
349124006033	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
349124006034	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
349124006035	active site
349124006036	DNA polymerase IV; Validated; Region: PRK02406
349124006037	DNA binding site [nucleotide binding]
349124006038	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124006039	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124006040	metal binding site [ion binding]; metal-binding site
349124006041	active site
349124006042	I-site; other site
349124006043	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
349124006044	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
349124006045	non-specific DNA binding site [nucleotide binding]; other site
349124006046	salt bridge; other site
349124006047	sequence-specific DNA binding site [nucleotide binding]; other site
349124006048	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
349124006049	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124006050	FeS/SAM binding site; other site
349124006051	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
349124006052	putative ligand binding pocket/active site [active]
349124006053	putative metal binding site [ion binding]; other site
349124006054	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
349124006055	AMMECR1; Region: AMMECR1; pfam01871
349124006056	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
349124006057	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
349124006058	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
349124006059	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
349124006060	Outer membrane efflux protein; Region: OEP; pfam02321
349124006061	Outer membrane efflux protein; Region: OEP; pfam02321
349124006062	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349124006063	Protein export membrane protein; Region: SecD_SecF; cl14618
349124006064	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349124006065	HlyD family secretion protein; Region: HlyD_3; pfam13437
349124006066	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
349124006067	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
349124006068	nucleotide binding pocket [chemical binding]; other site
349124006069	K-X-D-G motif; other site
349124006070	catalytic site [active]
349124006071	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
349124006072	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
349124006073	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
349124006074	Dimer interface [polypeptide binding]; other site
349124006075	BRCT sequence motif; other site
349124006076	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
349124006077	FtsZ protein binding site [polypeptide binding]; other site
349124006078	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
349124006079	AAA domain; Region: AAA_23; pfam13476
349124006080	Walker A/P-loop; other site
349124006081	ATP binding site [chemical binding]; other site
349124006082	Q-loop/lid; other site
349124006083	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
349124006084	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
349124006085	ABC transporter signature motif; other site
349124006086	Walker B; other site
349124006087	D-loop; other site
349124006088	H-loop/switch region; other site
349124006089	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
349124006090	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
349124006091	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
349124006092	active site
349124006093	HIGH motif; other site
349124006094	nucleotide binding site [chemical binding]; other site
349124006095	active site
349124006096	KMSKS motif; other site
349124006097	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
349124006098	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349124006099	N-terminal plug; other site
349124006100	ligand-binding site [chemical binding]; other site
349124006101	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
349124006102	Peptidase family M48; Region: Peptidase_M48; cl12018
349124006103	Bacterial SH3 domain; Region: SH3_3; pfam08239
349124006104	CHASE2 domain; Region: CHASE2; pfam05226
349124006105	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
349124006106	cyclase homology domain; Region: CHD; cd07302
349124006107	nucleotidyl binding site; other site
349124006108	metal binding site [ion binding]; metal-binding site
349124006109	dimer interface [polypeptide binding]; other site
349124006110	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
349124006111	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
349124006112	Na binding site [ion binding]; other site
349124006113	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
349124006114	PAS domain; Region: PAS; smart00091
349124006115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124006116	dimer interface [polypeptide binding]; other site
349124006117	phosphorylation site [posttranslational modification]
349124006118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124006119	ATP binding site [chemical binding]; other site
349124006120	Mg2+ binding site [ion binding]; other site
349124006121	G-X-G motif; other site
349124006122	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349124006123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124006124	active site
349124006125	phosphorylation site [posttranslational modification]
349124006126	intermolecular recognition site; other site
349124006127	dimerization interface [polypeptide binding]; other site
349124006128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124006129	Walker A motif; other site
349124006130	ATP binding site [chemical binding]; other site
349124006131	Walker B motif; other site
349124006132	arginine finger; other site
349124006133	acetyl-CoA synthetase; Provisional; Region: PRK00174
349124006134	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
349124006135	active site
349124006136	CoA binding site [chemical binding]; other site
349124006137	acyl-activating enzyme (AAE) consensus motif; other site
349124006138	AMP binding site [chemical binding]; other site
349124006139	acetate binding site [chemical binding]; other site
349124006140	Tetratricopeptide repeat; Region: TPR_16; pfam13432
349124006141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124006142	TPR motif; other site
349124006143	binding surface
349124006144	TPR repeat; Region: TPR_11; pfam13414
349124006145	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
349124006146	Na binding site [ion binding]; other site
349124006147	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
349124006148	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
349124006149	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
349124006150	ligand binding site [chemical binding]; other site
349124006151	flexible hinge region; other site
349124006152	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
349124006153	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349124006154	metal binding triad; other site
349124006155	Response regulator receiver domain; Region: Response_reg; pfam00072
349124006156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124006157	active site
349124006158	phosphorylation site [posttranslational modification]
349124006159	intermolecular recognition site; other site
349124006160	dimerization interface [polypeptide binding]; other site
349124006161	PAS domain; Region: PAS; smart00091
349124006162	PAS fold; Region: PAS_4; pfam08448
349124006163	putative active site [active]
349124006164	heme pocket [chemical binding]; other site
349124006165	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
349124006166	active site
349124006167	catalytic site [active]
349124006168	substrate binding site [chemical binding]; other site
349124006169	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
349124006170	Na binding site [ion binding]; other site
349124006171	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
349124006172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124006173	dimer interface [polypeptide binding]; other site
349124006174	phosphorylation site [posttranslational modification]
349124006175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124006176	ATP binding site [chemical binding]; other site
349124006177	Mg2+ binding site [ion binding]; other site
349124006178	G-X-G motif; other site
349124006179	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
349124006180	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
349124006181	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349124006182	N-terminal plug; other site
349124006183	ligand-binding site [chemical binding]; other site
349124006184	cobyric acid synthase; Provisional; Region: PRK00784
349124006185	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
349124006186	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
349124006187	catalytic triad [active]
349124006188	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
349124006189	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
349124006190	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
349124006191	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
349124006192	catalytic triad [active]
349124006193	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124006194	Ligand Binding Site [chemical binding]; other site
349124006195	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124006196	Ligand Binding Site [chemical binding]; other site
349124006197	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
349124006198	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
349124006199	Sulfate transporter family; Region: Sulfate_transp; pfam00916
349124006200	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
349124006201	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349124006202	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349124006203	P-loop; other site
349124006204	Magnesium ion binding site [ion binding]; other site
349124006205	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349124006206	Magnesium ion binding site [ion binding]; other site
349124006207	hypothetical protein; Validated; Region: PRK00124
349124006208	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
349124006209	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
349124006210	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349124006211	HlyD family secretion protein; Region: HlyD_3; pfam13437
349124006212	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
349124006213	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
349124006214	FtsX-like permease family; Region: FtsX; pfam02687
349124006215	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349124006216	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349124006217	Walker A/P-loop; other site
349124006218	ATP binding site [chemical binding]; other site
349124006219	Q-loop/lid; other site
349124006220	ABC transporter signature motif; other site
349124006221	Walker B; other site
349124006222	D-loop; other site
349124006223	H-loop/switch region; other site
349124006224	Uncharacterized conserved protein [Function unknown]; Region: COG0398
349124006225	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
349124006226	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
349124006227	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
349124006228	Walker A/P-loop; other site
349124006229	ATP binding site [chemical binding]; other site
349124006230	Q-loop/lid; other site
349124006231	ABC transporter signature motif; other site
349124006232	Walker B; other site
349124006233	D-loop; other site
349124006234	H-loop/switch region; other site
349124006235	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
349124006236	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349124006237	dimer interface [polypeptide binding]; other site
349124006238	putative PBP binding regions; other site
349124006239	ABC-ATPase subunit  interface; other site
349124006240	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
349124006241	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
349124006242	cobalamin binding residues [chemical binding]; other site
349124006243	putative BtuC binding residues; other site
349124006244	dimer interface [polypeptide binding]; other site
349124006245	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
349124006246	putative active site [active]
349124006247	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
349124006248	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
349124006249	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349124006250	N-terminal plug; other site
349124006251	ligand-binding site [chemical binding]; other site
349124006252	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
349124006253	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
349124006254	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
349124006255	N-terminal plug; other site
349124006256	ligand-binding site [chemical binding]; other site
349124006257	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
349124006258	Protein of unknown function (DUF1043); Region: DUF1043; cl11473
349124006259	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
349124006260	active site residue [active]
349124006261	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349124006262	siroheme synthase; Provisional; Region: cysG; PRK10637
349124006263	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
349124006264	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
349124006265	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
349124006266	active site
349124006267	SAM binding site [chemical binding]; other site
349124006268	homodimer interface [polypeptide binding]; other site
349124006269	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
349124006270	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
349124006271	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
349124006272	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349124006273	molybdopterin cofactor binding site; other site
349124006274	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
349124006275	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
349124006276	putative molybdopterin cofactor binding site; other site
349124006277	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
349124006278	CPxP  motif; other site
349124006279	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
349124006280	active site
349124006281	metal binding site [ion binding]; metal-binding site
349124006282	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
349124006283	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
349124006284	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
349124006285	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
349124006286	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
349124006287	DsrE/DsrF-like family; Region: DrsE; pfam02635
349124006288	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
349124006289	dimer interface [polypeptide binding]; other site
349124006290	catalytic residues [active]
349124006291	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
349124006292	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
349124006293	Cytochrome c; Region: Cytochrom_C; cl11414
349124006294	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
349124006295	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
349124006296	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
349124006297	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09733
349124006298	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
349124006299	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
349124006300	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
349124006301	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
349124006302	4Fe-4S binding domain; Region: Fer4; pfam00037
349124006303	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
349124006304	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
349124006305	DsrH like protein; Region: DsrH; pfam04077
349124006306	DsrC like protein; Region: DsrC; pfam04358
349124006307	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
349124006308	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
349124006309	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
349124006310	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
349124006311	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349124006312	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349124006313	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
349124006314	4Fe-4S binding domain; Region: Fer4; cl02805
349124006315	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
349124006316	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
349124006317	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
349124006318	catalytic triad [active]
349124006319	GAF domain; Region: GAF_2; pfam13185
349124006320	GAF domain; Region: GAF_3; pfam13492
349124006321	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
349124006322	Histidine kinase; Region: HisKA_3; pfam07730
349124006323	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124006324	ATP binding site [chemical binding]; other site
349124006325	Mg2+ binding site [ion binding]; other site
349124006326	G-X-G motif; other site
349124006327	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
349124006328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124006329	active site
349124006330	phosphorylation site [posttranslational modification]
349124006331	intermolecular recognition site; other site
349124006332	dimerization interface [polypeptide binding]; other site
349124006333	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
349124006334	DNA binding residues [nucleotide binding]
349124006335	dimerization interface [polypeptide binding]; other site
349124006336	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
349124006337	high affinity sulphate transporter 1; Region: sulP; TIGR00815
349124006338	Sulfate transporter family; Region: Sulfate_transp; pfam00916
349124006339	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
349124006340	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
349124006341	Family of unknown function (DUF490); Region: DUF490; pfam04357
349124006342	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
349124006343	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349124006344	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
349124006345	Surface antigen; Region: Bac_surface_Ag; pfam01103
349124006346	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
349124006347	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349124006348	Coenzyme A binding pocket [chemical binding]; other site
349124006349	Predicted amidohydrolase [General function prediction only]; Region: COG0388
349124006350	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
349124006351	putative active site [active]
349124006352	catalytic triad [active]
349124006353	putative dimer interface [polypeptide binding]; other site
349124006354	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
349124006355	GSH binding site [chemical binding]; other site
349124006356	catalytic residues [active]
349124006357	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
349124006358	probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406
349124006359	aspartate aminotransferase; Provisional; Region: PRK05764
349124006360	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349124006361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124006362	homodimer interface [polypeptide binding]; other site
349124006363	catalytic residue [active]
349124006364	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
349124006365	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
349124006366	NAD binding site [chemical binding]; other site
349124006367	ligand binding site [chemical binding]; other site
349124006368	catalytic site [active]
349124006369	putative amidase; Provisional; Region: PRK06169
349124006370	Amidase; Region: Amidase; pfam01425
349124006371	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
349124006372	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
349124006373	tetramerization interface [polypeptide binding]; other site
349124006374	NAD(P) binding site [chemical binding]; other site
349124006375	catalytic residues [active]
349124006376	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
349124006377	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349124006378	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
349124006379	motif 1; other site
349124006380	dimer interface [polypeptide binding]; other site
349124006381	active site
349124006382	motif 2; other site
349124006383	motif 3; other site
349124006384	elongation factor P; Validated; Region: PRK00529
349124006385	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
349124006386	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
349124006387	RNA binding site [nucleotide binding]; other site
349124006388	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
349124006389	RNA binding site [nucleotide binding]; other site
349124006390	Radical SAM superfamily; Region: Radical_SAM; pfam04055
349124006391	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124006392	FeS/SAM binding site; other site
349124006393	heat shock protein HtpX; Provisional; Region: PRK05457
349124006394	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
349124006395	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
349124006396	CAP-like domain; other site
349124006397	active site
349124006398	primary dimer interface [polypeptide binding]; other site
349124006399	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
349124006400	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
349124006401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124006402	Mg2+ binding site [ion binding]; other site
349124006403	G-X-G motif; other site
349124006404	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
349124006405	anchoring element; other site
349124006406	dimer interface [polypeptide binding]; other site
349124006407	ATP binding site [chemical binding]; other site
349124006408	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
349124006409	active site
349124006410	metal binding site [ion binding]; metal-binding site
349124006411	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
349124006412	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
349124006413	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
349124006414	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
349124006415	substrate binding pocket [chemical binding]; other site
349124006416	chain length determination region; other site
349124006417	substrate-Mg2+ binding site; other site
349124006418	catalytic residues [active]
349124006419	aspartate-rich region 1; other site
349124006420	active site lid residues [active]
349124006421	aspartate-rich region 2; other site
349124006422	putative GTP cyclohydrolase; Provisional; Region: PRK13674
349124006423	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
349124006424	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
349124006425	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349124006426	HlyD family secretion protein; Region: HlyD_3; pfam13437
349124006427	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349124006428	Protein export membrane protein; Region: SecD_SecF; cl14618
349124006429	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
349124006430	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
349124006431	metal binding site 2 [ion binding]; metal-binding site
349124006432	putative DNA binding helix; other site
349124006433	metal binding site 1 [ion binding]; metal-binding site
349124006434	dimer interface [polypeptide binding]; other site
349124006435	structural Zn2+ binding site [ion binding]; other site
349124006436	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
349124006437	Cation efflux family; Region: Cation_efflux; pfam01545
349124006438	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
349124006439	serine/threonine protein kinase; Provisional; Region: PRK11768
349124006440	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
349124006441	Peptidase family M23; Region: Peptidase_M23; pfam01551
349124006442	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
349124006443	plasmid segregation protein ParM; Provisional; Region: PRK13917
349124006444	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
349124006445	Mg binding site [ion binding]; other site
349124006446	nucleotide binding site [chemical binding]; other site
349124006447	putative protofilament interface [polypeptide binding]; other site
349124006448	Phasin protein; Region: Phasin_2; pfam09361
349124006449	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
349124006450	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
349124006451	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
349124006452	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
349124006453	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
349124006454	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
349124006455	purine monophosphate binding site [chemical binding]; other site
349124006456	dimer interface [polypeptide binding]; other site
349124006457	putative catalytic residues [active]
349124006458	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
349124006459	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
349124006460	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
349124006461	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
349124006462	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
349124006463	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
349124006464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
349124006465	S-adenosylmethionine binding site [chemical binding]; other site
349124006466	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
349124006467	dimer interface [polypeptide binding]; other site
349124006468	substrate binding site [chemical binding]; other site
349124006469	metal binding sites [ion binding]; metal-binding site
349124006470	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349124006471	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
349124006472	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349124006473	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349124006474	aromatic acid decarboxylase; Validated; Region: PRK05920
349124006475	Flavoprotein; Region: Flavoprotein; pfam02441
349124006476	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
349124006477	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
349124006478	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
349124006479	LssY C-terminus; Region: LssY_C; pfam14067
349124006480	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
349124006481	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
349124006482	inhibitor-cofactor binding pocket; inhibition site
349124006483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124006484	catalytic residue [active]
349124006485	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
349124006486	thiamine phosphate binding site [chemical binding]; other site
349124006487	active site
349124006488	pyrophosphate binding site [ion binding]; other site
349124006489	Rubredoxin [Energy production and conversion]; Region: COG1773
349124006490	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
349124006491	iron binding site [ion binding]; other site
349124006492	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
349124006493	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
349124006494	DEAD-like helicases superfamily; Region: DEXDc; smart00487
349124006495	ATP binding site [chemical binding]; other site
349124006496	Mg++ binding site [ion binding]; other site
349124006497	motif III; other site
349124006498	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
349124006499	nucleotide binding region [chemical binding]; other site
349124006500	ATP-binding site [chemical binding]; other site
349124006501	FOG: CBS domain [General function prediction only]; Region: COG0517
349124006502	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
349124006503	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
349124006504	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349124006505	ligand binding site [chemical binding]; other site
349124006506	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
349124006507	Type II/IV secretion system protein; Region: T2SE; pfam00437
349124006508	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349124006509	Walker A motif; other site
349124006510	ATP binding site [chemical binding]; other site
349124006511	Walker B motif; other site
349124006512	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
349124006513	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349124006514	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
349124006515	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
349124006516	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
349124006517	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
349124006518	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
349124006519	CoA-binding site [chemical binding]; other site
349124006520	ATP-binding [chemical binding]; other site
349124006521	hypothetical protein; Provisional; Region: PRK05287
349124006522	hypothetical protein; Provisional; Region: PRK08999
349124006523	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
349124006524	active site
349124006525	8-oxo-dGMP binding site [chemical binding]; other site
349124006526	nudix motif; other site
349124006527	metal binding site [ion binding]; metal-binding site
349124006528	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
349124006529	thiamine phosphate binding site [chemical binding]; other site
349124006530	active site
349124006531	pyrophosphate binding site [ion binding]; other site
349124006532	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
349124006533	heterotetramer interface [polypeptide binding]; other site
349124006534	active site pocket [active]
349124006535	cleavage site
349124006536	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
349124006537	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
349124006538	SEC-C motif; Region: SEC-C; pfam02810
349124006539	Protein of unknown function (DUF721); Region: DUF721; pfam05258
349124006540	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
349124006541	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
349124006542	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
349124006543	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
349124006544	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349124006545	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659
349124006546	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509
349124006547	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
349124006548	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
349124006549	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
349124006550	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
349124006551	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
349124006552	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
349124006553	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
349124006554	putative acyl-acceptor binding pocket; other site
349124006555	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
349124006556	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
349124006557	eyelet of channel; other site
349124006558	trimer interface [polypeptide binding]; other site
349124006559	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
349124006560	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
349124006561	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
349124006562	dimerization interface [polypeptide binding]; other site
349124006563	active site
349124006564	PUA domain; Region: PUA; cl00607
349124006565	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
349124006566	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
349124006567	putative RNA binding site [nucleotide binding]; other site
349124006568	Methyltransferase domain; Region: Methyltransf_26; pfam13659
349124006569	Bacterial SH3 domain homologues; Region: SH3b; smart00287
349124006570	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
349124006571	acetylornithine deacetylase; Provisional; Region: PRK05111
349124006572	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
349124006573	metal binding site [ion binding]; metal-binding site
349124006574	putative dimer interface [polypeptide binding]; other site
349124006575	N-acetylglutamate synthase; Validated; Region: PRK05279
349124006576	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
349124006577	putative feedback inhibition sensing region; other site
349124006578	putative nucleotide binding site [chemical binding]; other site
349124006579	putative substrate binding site [chemical binding]; other site
349124006580	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
349124006581	Coenzyme A binding pocket [chemical binding]; other site
349124006582	thymidylate synthase; Reviewed; Region: thyA; PRK01827
349124006583	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
349124006584	dimerization interface [polypeptide binding]; other site
349124006585	active site
349124006586	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
349124006587	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
349124006588	folate binding site [chemical binding]; other site
349124006589	NADP+ binding site [chemical binding]; other site
349124006590	Radical SAM superfamily; Region: Radical_SAM; pfam04055
349124006591	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
349124006592	FeS/SAM binding site; other site
349124006593	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
349124006594	trimer interface [polypeptide binding]; other site
349124006595	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
349124006596	eyelet of channel; other site
349124006597	LPP20 lipoprotein; Region: LPP20; cl15824
349124006598	transcription termination factor Rho; Provisional; Region: rho; PRK09376
349124006599	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
349124006600	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
349124006601	RNA binding site [nucleotide binding]; other site
349124006602	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
349124006603	multimer interface [polypeptide binding]; other site
349124006604	Walker A motif; other site
349124006605	ATP binding site [chemical binding]; other site
349124006606	Walker B motif; other site
349124006607	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
349124006608	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
349124006609	catalytic residues [active]
349124006610	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
349124006611	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
349124006612	active site
349124006613	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
349124006614	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
349124006615	dimer interface [polypeptide binding]; other site
349124006616	ADP-ribose binding site [chemical binding]; other site
349124006617	active site
349124006618	nudix motif; other site
349124006619	metal binding site [ion binding]; metal-binding site
349124006620	Acetokinase family; Region: Acetate_kinase; cl17229
349124006621	propionate/acetate kinase; Provisional; Region: PRK12379
349124006622	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
349124006623	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
349124006624	active site 2 [active]
349124006625	active site 1 [active]
349124006626	phosphate acetyltransferase; Provisional; Region: PRK11890
349124006627	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
349124006628	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
349124006629	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
349124006630	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
349124006631	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
349124006632	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
349124006633	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
349124006634	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
349124006635	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
349124006636	Walker A/P-loop; other site
349124006637	ATP binding site [chemical binding]; other site
349124006638	Q-loop/lid; other site
349124006639	ABC transporter signature motif; other site
349124006640	Walker B; other site
349124006641	D-loop; other site
349124006642	H-loop/switch region; other site
349124006643	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
349124006644	active site
349124006645	catalytic triad [active]
349124006646	oxyanion hole [active]
349124006647	switch loop; other site
349124006648	Putative exonuclease, RdgC; Region: RdgC; pfam04381
349124006649	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
349124006650	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349124006651	AIR carboxylase; Region: AIRC; pfam00731
349124006652	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
349124006653	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
349124006654	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
349124006655	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
349124006656	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
349124006657	23S rRNA interface [nucleotide binding]; other site
349124006658	L3 interface [polypeptide binding]; other site
349124006659	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
349124006660	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
349124006661	active site
349124006662	ribulose/triose binding site [chemical binding]; other site
349124006663	phosphate binding site [ion binding]; other site
349124006664	substrate (anthranilate) binding pocket [chemical binding]; other site
349124006665	product (indole) binding pocket [chemical binding]; other site
349124006666	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
349124006667	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
349124006668	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
349124006669	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
349124006670	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
349124006671	glutamine binding [chemical binding]; other site
349124006672	catalytic triad [active]
349124006673	anthranilate synthase component I; Provisional; Region: PRK13565
349124006674	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
349124006675	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
349124006676	phosphoglycolate phosphatase; Provisional; Region: PRK13222
349124006677	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
349124006678	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349124006679	motif II; other site
349124006680	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
349124006681	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
349124006682	cell division protein FtsZ; Validated; Region: PRK09330
349124006683	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
349124006684	nucleotide binding site [chemical binding]; other site
349124006685	SulA interaction site; other site
349124006686	cell division protein FtsA; Region: ftsA; TIGR01174
349124006687	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
349124006688	nucleotide binding site [chemical binding]; other site
349124006689	Cell division protein FtsA; Region: FtsA; pfam14450
349124006690	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
349124006691	Cell division protein FtsQ; Region: FtsQ; pfam03799
349124006692	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
349124006693	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
349124006694	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349124006695	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
349124006696	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
349124006697	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
349124006698	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349124006699	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349124006700	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349124006701	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
349124006702	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
349124006703	active site
349124006704	homodimer interface [polypeptide binding]; other site
349124006705	cell division protein FtsW; Region: ftsW; TIGR02614
349124006706	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
349124006707	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349124006708	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349124006709	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
349124006710	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
349124006711	Mg++ binding site [ion binding]; other site
349124006712	putative catalytic motif [active]
349124006713	putative substrate binding site [chemical binding]; other site
349124006714	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
349124006715	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
349124006716	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349124006717	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
349124006718	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
349124006719	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
349124006720	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
349124006721	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
349124006722	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
349124006723	Cell division protein FtsL; Region: FtsL; pfam04999
349124006724	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
349124006725	MraW methylase family; Region: Methyltransf_5; cl17771
349124006726	cell division protein MraZ; Reviewed; Region: PRK00326
349124006727	MraZ protein; Region: MraZ; pfam02381
349124006728	MraZ protein; Region: MraZ; pfam02381
349124006729	Predicted methyltransferases [General function prediction only]; Region: COG0313
349124006730	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
349124006731	putative SAM binding site [chemical binding]; other site
349124006732	putative homodimer interface [polypeptide binding]; other site
349124006733	LppC putative lipoprotein; Region: LppC; pfam04348
349124006734	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
349124006735	putative ligand binding site [chemical binding]; other site
349124006736	hypothetical protein; Reviewed; Region: PRK12497
349124006737	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
349124006738	dimer interface [polypeptide binding]; other site
349124006739	active site
349124006740	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
349124006741	stringent starvation protein A; Provisional; Region: sspA; PRK09481
349124006742	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349124006743	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
349124006744	dimer interface [polypeptide binding]; other site
349124006745	N-terminal domain interface [polypeptide binding]; other site
349124006746	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
349124006747	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
349124006748	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
349124006749	intrachain domain interface; other site
349124006750	interchain domain interface [polypeptide binding]; other site
349124006751	heme bH binding site [chemical binding]; other site
349124006752	Qi binding site; other site
349124006753	heme bL binding site [chemical binding]; other site
349124006754	Qo binding site; other site
349124006755	interchain domain interface [polypeptide binding]; other site
349124006756	intrachain domain interface; other site
349124006757	Qi binding site; other site
349124006758	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
349124006759	Qo binding site; other site
349124006760	Uncharacterized conserved protein [Function unknown]; Region: COG0327
349124006761	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
349124006762	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
349124006763	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
349124006764	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349124006765	protein binding site [polypeptide binding]; other site
349124006766	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
349124006767	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
349124006768	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124006769	homodimer interface [polypeptide binding]; other site
349124006770	catalytic residue [active]
349124006771	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
349124006772	histidinol dehydrogenase; Region: hisD; TIGR00069
349124006773	NAD binding site [chemical binding]; other site
349124006774	dimerization interface [polypeptide binding]; other site
349124006775	product binding site; other site
349124006776	substrate binding site [chemical binding]; other site
349124006777	zinc binding site [ion binding]; other site
349124006778	catalytic residues [active]
349124006779	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
349124006780	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
349124006781	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
349124006782	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
349124006783	hinge; other site
349124006784	active site
349124006785	BolA-like protein; Region: BolA; cl00386
349124006786	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349124006787	anti sigma factor interaction site; other site
349124006788	regulatory phosphorylation site [posttranslational modification]; other site
349124006789	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
349124006790	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
349124006791	mce related protein; Region: MCE; pfam02470
349124006792	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
349124006793	Permease; Region: Permease; pfam02405
349124006794	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
349124006795	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
349124006796	Walker A/P-loop; other site
349124006797	ATP binding site [chemical binding]; other site
349124006798	Q-loop/lid; other site
349124006799	ABC transporter signature motif; other site
349124006800	Walker B; other site
349124006801	D-loop; other site
349124006802	H-loop/switch region; other site
349124006803	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
349124006804	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
349124006805	putative active site [active]
349124006806	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
349124006807	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
349124006808	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
349124006809	active site
349124006810	motif I; other site
349124006811	motif II; other site
349124006812	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
349124006813	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
349124006814	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
349124006815	OstA-like protein; Region: OstA; pfam03968
349124006816	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
349124006817	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
349124006818	Walker A/P-loop; other site
349124006819	ATP binding site [chemical binding]; other site
349124006820	Q-loop/lid; other site
349124006821	ABC transporter signature motif; other site
349124006822	Walker B; other site
349124006823	D-loop; other site
349124006824	H-loop/switch region; other site
349124006825	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
349124006826	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
349124006827	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
349124006828	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
349124006829	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
349124006830	30S subunit binding site; other site
349124006831	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
349124006832	active site
349124006833	phosphorylation site [posttranslational modification]
349124006834	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
349124006835	Hpr binding site; other site
349124006836	active site
349124006837	homohexamer subunit interaction site [polypeptide binding]; other site
349124006838	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
349124006839	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
349124006840	active pocket/dimerization site; other site
349124006841	active site
349124006842	phosphorylation site [posttranslational modification]
349124006843	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
349124006844	dimerization domain swap beta strand [polypeptide binding]; other site
349124006845	regulatory protein interface [polypeptide binding]; other site
349124006846	active site
349124006847	regulatory phosphorylation site [posttranslational modification]; other site
349124006848	peptidase PmbA; Provisional; Region: PRK11040
349124006849	protease TldD; Provisional; Region: tldD; PRK10735
349124006850	nitrilase; Region: PLN02798
349124006851	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
349124006852	putative active site [active]
349124006853	catalytic triad [active]
349124006854	dimer interface [polypeptide binding]; other site
349124006855	Protein of unknown function; Region: DUF3971; pfam13116
349124006856	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
349124006857	ribonuclease G; Provisional; Region: PRK11712
349124006858	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
349124006859	homodimer interface [polypeptide binding]; other site
349124006860	oligonucleotide binding site [chemical binding]; other site
349124006861	Maf-like protein; Region: Maf; pfam02545
349124006862	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
349124006863	active site
349124006864	dimer interface [polypeptide binding]; other site
349124006865	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
349124006866	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
349124006867	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
349124006868	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
349124006869	active site
349124006870	(T/H)XGH motif; other site
349124006871	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
349124006872	putative catalytic cysteine [active]
349124006873	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
349124006874	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
349124006875	Lipopolysaccharide-assembly; Region: LptE; cl01125
349124006876	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
349124006877	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
349124006878	HIGH motif; other site
349124006879	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
349124006880	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
349124006881	active site
349124006882	KMSKS motif; other site
349124006883	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
349124006884	tRNA binding surface [nucleotide binding]; other site
349124006885	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
349124006886	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
349124006887	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
349124006888	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
349124006889	hydrophobic ligand binding site; other site
349124006890	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
349124006891	GAF domain; Region: GAF; pfam01590
349124006892	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349124006893	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124006894	putative active site [active]
349124006895	heme pocket [chemical binding]; other site
349124006896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124006897	dimer interface [polypeptide binding]; other site
349124006898	phosphorylation site [posttranslational modification]
349124006899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124006900	ATP binding site [chemical binding]; other site
349124006901	Mg2+ binding site [ion binding]; other site
349124006902	G-X-G motif; other site
349124006903	Response regulator receiver domain; Region: Response_reg; pfam00072
349124006904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124006905	active site
349124006906	phosphorylation site [posttranslational modification]
349124006907	intermolecular recognition site; other site
349124006908	dimerization interface [polypeptide binding]; other site
349124006909	FOG: CBS domain [General function prediction only]; Region: COG0517
349124006910	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
349124006911	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
349124006912	FOG: CBS domain [General function prediction only]; Region: COG0517
349124006913	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
349124006914	FOG: CBS domain [General function prediction only]; Region: COG0517
349124006915	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
349124006916	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124006917	PAS fold; Region: PAS_3; pfam08447
349124006918	putative active site [active]
349124006919	heme pocket [chemical binding]; other site
349124006920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124006921	PAS fold; Region: PAS_3; pfam08447
349124006922	putative active site [active]
349124006923	heme pocket [chemical binding]; other site
349124006924	PAS domain S-box; Region: sensory_box; TIGR00229
349124006925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
349124006926	putative active site [active]
349124006927	heme pocket [chemical binding]; other site
349124006928	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
349124006929	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124006930	dimer interface [polypeptide binding]; other site
349124006931	phosphorylation site [posttranslational modification]
349124006932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124006933	ATP binding site [chemical binding]; other site
349124006934	Mg2+ binding site [ion binding]; other site
349124006935	G-X-G motif; other site
349124006936	Response regulator receiver domain; Region: Response_reg; pfam00072
349124006937	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124006938	active site
349124006939	phosphorylation site [posttranslational modification]
349124006940	intermolecular recognition site; other site
349124006941	dimerization interface [polypeptide binding]; other site
349124006942	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349124006943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124006944	active site
349124006945	phosphorylation site [posttranslational modification]
349124006946	intermolecular recognition site; other site
349124006947	dimerization interface [polypeptide binding]; other site
349124006948	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349124006949	putative binding surface; other site
349124006950	active site
349124006951	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
349124006952	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
349124006953	dimer interface [polypeptide binding]; other site
349124006954	phosphorylation site [posttranslational modification]
349124006955	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124006956	ATP binding site [chemical binding]; other site
349124006957	Mg2+ binding site [ion binding]; other site
349124006958	G-X-G motif; other site
349124006959	Response regulator receiver domain; Region: Response_reg; pfam00072
349124006960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124006961	active site
349124006962	phosphorylation site [posttranslational modification]
349124006963	intermolecular recognition site; other site
349124006964	dimerization interface [polypeptide binding]; other site
349124006965	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349124006966	putative binding surface; other site
349124006967	active site
349124006968	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
349124006969	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349124006970	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349124006971	ABC transporter; Region: ABC_tran_2; pfam12848
349124006972	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
349124006973	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
349124006974	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
349124006975	homodimer interface [polypeptide binding]; other site
349124006976	substrate-cofactor binding pocket; other site
349124006977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
349124006978	catalytic residue [active]
349124006979	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
349124006980	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
349124006981	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
349124006982	substrate binding pocket [chemical binding]; other site
349124006983	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
349124006984	B12 binding site [chemical binding]; other site
349124006985	cobalt ligand [ion binding]; other site
349124006986	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
349124006987	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
349124006988	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
349124006989	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
349124006990	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
349124006991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124006992	Response regulator receiver domain; Region: Response_reg; pfam00072
349124006993	active site
349124006994	phosphorylation site [posttranslational modification]
349124006995	intermolecular recognition site; other site
349124006996	dimerization interface [polypeptide binding]; other site
349124006997	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
349124006998	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
349124006999	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
349124007000	ATP binding site [chemical binding]; other site
349124007001	Mg2+ binding site [ion binding]; other site
349124007002	G-X-G motif; other site
349124007003	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
349124007004	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349124007005	anti sigma factor interaction site; other site
349124007006	regulatory phosphorylation site [posttranslational modification]; other site
349124007007	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
349124007008	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124007009	dimer interface [polypeptide binding]; other site
349124007010	putative CheW interface [polypeptide binding]; other site
349124007011	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
349124007012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124007013	active site
349124007014	phosphorylation site [posttranslational modification]
349124007015	intermolecular recognition site; other site
349124007016	dimerization interface [polypeptide binding]; other site
349124007017	CheB methylesterase; Region: CheB_methylest; pfam01339
349124007018	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487
349124007019	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
349124007020	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
349124007021	PAS domain; Region: PAS_9; pfam13426
349124007022	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
349124007023	dimerization interface [polypeptide binding]; other site
349124007024	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124007025	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124007026	dimer interface [polypeptide binding]; other site
349124007027	putative CheW interface [polypeptide binding]; other site
349124007028	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349124007029	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349124007030	P-loop; other site
349124007031	Magnesium ion binding site [ion binding]; other site
349124007032	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349124007033	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
349124007034	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
349124007035	dimer interface [polypeptide binding]; other site
349124007036	putative CheW interface [polypeptide binding]; other site
349124007037	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
349124007038	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
349124007039	putative CheA interaction surface; other site
349124007040	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
349124007041	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
349124007042	putative binding surface; other site
349124007043	active site
349124007044	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
349124007045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124007046	ATP binding site [chemical binding]; other site
349124007047	Mg2+ binding site [ion binding]; other site
349124007048	G-X-G motif; other site
349124007049	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
349124007050	Response regulator receiver domain; Region: Response_reg; pfam00072
349124007051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124007052	active site
349124007053	phosphorylation site [posttranslational modification]
349124007054	intermolecular recognition site; other site
349124007055	dimerization interface [polypeptide binding]; other site
349124007056	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
349124007057	anti sigma factor interaction site; other site
349124007058	regulatory phosphorylation site [posttranslational modification]; other site
349124007059	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
349124007060	Isochorismatase family; Region: Isochorismatase; pfam00857
349124007061	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
349124007062	catalytic triad [active]
349124007063	dimer interface [polypeptide binding]; other site
349124007064	conserved cis-peptide bond; other site
349124007065	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
349124007066	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
349124007067	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
349124007068	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
349124007069	ABC-ATPase subunit  interface; other site
349124007070	dimer interface [polypeptide binding]; other site
349124007071	putative PBP binding regions; other site
349124007072	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
349124007073	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
349124007074	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
349124007075	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
349124007076	metal binding site [ion binding]; metal-binding site
349124007077	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
349124007078	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
349124007079	active site
349124007080	dimer interface [polypeptide binding]; other site
349124007081	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
349124007082	dimer interface [polypeptide binding]; other site
349124007083	active site
349124007084	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
349124007085	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
349124007086	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
349124007087	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
349124007088	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
349124007089	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
349124007090	putative NAD(P) binding site [chemical binding]; other site
349124007091	active site
349124007092	putative substrate binding site [chemical binding]; other site
349124007093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124007094	S-adenosylmethionine binding site [chemical binding]; other site
349124007095	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
349124007096	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
349124007097	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
349124007098	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
349124007099	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
349124007100	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
349124007101	dimer interface [polypeptide binding]; other site
349124007102	ssDNA binding site [nucleotide binding]; other site
349124007103	tetramer (dimer of dimers) interface [polypeptide binding]; other site
349124007104	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
349124007105	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
349124007106	metal-binding site [ion binding]
349124007107	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
349124007108	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
349124007109	metal-binding site [ion binding]
349124007110	Ion transport protein; Region: Ion_trans; pfam00520
349124007111	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
349124007112	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
349124007113	putative dimer interface [polypeptide binding]; other site
349124007114	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124007115	Ligand Binding Site [chemical binding]; other site
349124007116	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
349124007117	Carbon starvation protein CstA; Region: CstA; pfam02554
349124007118	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
349124007119	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
349124007120	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
349124007121	P loop; other site
349124007122	Nucleotide binding site [chemical binding]; other site
349124007123	DTAP/Switch II; other site
349124007124	Switch I; other site
349124007125	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
349124007126	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
349124007127	NADP binding site [chemical binding]; other site
349124007128	dimer interface [polypeptide binding]; other site
349124007129	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
349124007130	active site
349124007131	tetramer interface; other site
349124007132	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
349124007133	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
349124007134	dimerization interface [polypeptide binding]; other site
349124007135	ATP binding site [chemical binding]; other site
349124007136	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
349124007137	dimerization interface [polypeptide binding]; other site
349124007138	ATP binding site [chemical binding]; other site
349124007139	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
349124007140	putative active site [active]
349124007141	catalytic triad [active]
349124007142	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
349124007143	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
349124007144	dihydrodipicolinate synthase; Region: dapA; TIGR00674
349124007145	dimer interface [polypeptide binding]; other site
349124007146	active site
349124007147	catalytic residue [active]
349124007148	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
349124007149	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
349124007150	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
349124007151	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
349124007152	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
349124007153	putative active site [active]
349124007154	PhoH-like protein; Region: PhoH; pfam02562
349124007155	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
349124007156	Domain of unknown function DUF20; Region: UPF0118; pfam01594
349124007157	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
349124007158	Peptidase family M48; Region: Peptidase_M48; pfam01435
349124007159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
349124007160	TPR motif; other site
349124007161	binding surface
349124007162	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
349124007163	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
349124007164	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
349124007165	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
349124007166	NAD(P) binding site [chemical binding]; other site
349124007167	homotetramer interface [polypeptide binding]; other site
349124007168	homodimer interface [polypeptide binding]; other site
349124007169	active site
349124007170	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
349124007171	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
349124007172	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
349124007173	HDOD domain; Region: HDOD; pfam08668
349124007174	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
349124007175	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
349124007176	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
349124007177	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
349124007178	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
349124007179	acyl-activating enzyme (AAE) consensus motif; other site
349124007180	putative AMP binding site [chemical binding]; other site
349124007181	putative active site [active]
349124007182	putative CoA binding site [chemical binding]; other site
349124007183	hypothetical protein; Validated; Region: PRK00110
349124007184	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
349124007185	active site
349124007186	putative DNA-binding cleft [nucleotide binding]; other site
349124007187	dimer interface [polypeptide binding]; other site
349124007188	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
349124007189	RuvA N terminal domain; Region: RuvA_N; pfam01330
349124007190	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
349124007191	helix-hairpin-helix signature motif; other site
349124007192	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
349124007193	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
349124007194	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124007195	Walker A motif; other site
349124007196	ATP binding site [chemical binding]; other site
349124007197	Walker B motif; other site
349124007198	arginine finger; other site
349124007199	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
349124007200	TolQ protein; Region: tolQ; TIGR02796
349124007201	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
349124007202	TolR protein; Region: tolR; TIGR02801
349124007203	TolA protein; Region: tolA_full; TIGR02794
349124007204	TonB C terminal; Region: TonB_2; pfam13103
349124007205	translocation protein TolB; Provisional; Region: tolB; PRK04922
349124007206	TolB amino-terminal domain; Region: TolB_N; pfam04052
349124007207	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
349124007208	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
349124007209	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
349124007210	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
349124007211	ligand binding site [chemical binding]; other site
349124007212	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
349124007213	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
349124007214	Catalytic site [active]
349124007215	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
349124007216	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
349124007217	putative active site [active]
349124007218	hydroxylamine reductase; Provisional; Region: PRK12310
349124007219	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
349124007220	ACS interaction site; other site
349124007221	CODH interaction site; other site
349124007222	metal cluster binding site [ion binding]; other site
349124007223	Transcriptional regulator; Region: Rrf2; cl17282
349124007224	Rrf2 family protein; Region: rrf2_super; TIGR00738
349124007225	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
349124007226	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
349124007227	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
349124007228	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
349124007229	dimer interface [polypeptide binding]; other site
349124007230	anticodon binding site; other site
349124007231	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
349124007232	homodimer interface [polypeptide binding]; other site
349124007233	motif 1; other site
349124007234	active site
349124007235	motif 2; other site
349124007236	GAD domain; Region: GAD; pfam02938
349124007237	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
349124007238	active site
349124007239	motif 3; other site
349124007240	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
349124007241	tetramer interface [polypeptide binding]; other site
349124007242	dimer interface [polypeptide binding]; other site
349124007243	circadian clock protein KaiC; Reviewed; Region: PRK09302
349124007244	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349124007245	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349124007246	Walker A motif; other site
349124007247	Walker A motif; other site
349124007248	ATP binding site [chemical binding]; other site
349124007249	Walker B motif; other site
349124007250	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
349124007251	ATP binding site [chemical binding]; other site
349124007252	Walker B motif; other site
349124007253	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
349124007254	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
349124007255	N-acetyl-D-glucosamine binding site [chemical binding]; other site
349124007256	catalytic residue [active]
349124007257	short chain dehydrogenase; Provisional; Region: PRK05993
349124007258	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
349124007259	NADP binding site [chemical binding]; other site
349124007260	active site
349124007261	steroid binding site; other site
349124007262	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
349124007263	Clp amino terminal domain; Region: Clp_N; pfam02861
349124007264	Clp amino terminal domain; Region: Clp_N; pfam02861
349124007265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124007266	Walker A motif; other site
349124007267	ATP binding site [chemical binding]; other site
349124007268	Walker B motif; other site
349124007269	arginine finger; other site
349124007270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124007271	Walker A motif; other site
349124007272	ATP binding site [chemical binding]; other site
349124007273	Walker B motif; other site
349124007274	arginine finger; other site
349124007275	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
349124007276	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
349124007277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124007278	active site
349124007279	phosphorylation site [posttranslational modification]
349124007280	intermolecular recognition site; other site
349124007281	dimerization interface [polypeptide binding]; other site
349124007282	Response regulator receiver domain; Region: Response_reg; pfam00072
349124007283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124007284	active site
349124007285	phosphorylation site [posttranslational modification]
349124007286	intermolecular recognition site; other site
349124007287	dimerization interface [polypeptide binding]; other site
349124007288	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
349124007289	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
349124007290	metal binding site [ion binding]; metal-binding site
349124007291	active site
349124007292	I-site; other site
349124007293	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
349124007294	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
349124007295	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
349124007296	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
349124007297	RNA binding surface [nucleotide binding]; other site
349124007298	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
349124007299	active site
349124007300	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
349124007301	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
349124007302	Nitrogen regulatory protein P-II; Region: P-II; smart00938
349124007303	NAD synthetase; Provisional; Region: PRK13981
349124007304	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
349124007305	multimer interface [polypeptide binding]; other site
349124007306	active site
349124007307	catalytic triad [active]
349124007308	protein interface 1 [polypeptide binding]; other site
349124007309	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
349124007310	homodimer interface [polypeptide binding]; other site
349124007311	NAD binding pocket [chemical binding]; other site
349124007312	ATP binding pocket [chemical binding]; other site
349124007313	Mg binding site [ion binding]; other site
349124007314	active-site loop [active]
349124007315	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
349124007316	CoA binding domain; Region: CoA_binding; smart00881
349124007317	CoA-ligase; Region: Ligase_CoA; pfam00549
349124007318	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
349124007319	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
349124007320	CoA-ligase; Region: Ligase_CoA; pfam00549
349124007321	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
349124007322	Pilin (bacterial filament); Region: Pilin; pfam00114
349124007323	hypothetical protein; Provisional; Region: PRK04358
349124007324	Transposase IS200 like; Region: Y1_Tnp; cl00848
349124007325	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
349124007326	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
349124007327	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
349124007328	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
349124007329	RNA binding site [nucleotide binding]; other site
349124007330	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
349124007331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124007332	Walker A/P-loop; other site
349124007333	ATP binding site [chemical binding]; other site
349124007334	Q-loop/lid; other site
349124007335	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124007336	ABC transporter signature motif; other site
349124007337	Walker B; other site
349124007338	D-loop; other site
349124007339	H-loop/switch region; other site
349124007340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124007341	Walker A/P-loop; other site
349124007342	ATP binding site [chemical binding]; other site
349124007343	Q-loop/lid; other site
349124007344	ABC transporter signature motif; other site
349124007345	Walker B; other site
349124007346	D-loop; other site
349124007347	H-loop/switch region; other site
349124007348	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124007349	Walker A/P-loop; other site
349124007350	ATP binding site [chemical binding]; other site
349124007351	Q-loop/lid; other site
349124007352	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
349124007353	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124007354	Walker A/P-loop; other site
349124007355	ATP binding site [chemical binding]; other site
349124007356	Q-loop/lid; other site
349124007357	ABC transporter signature motif; other site
349124007358	Walker B; other site
349124007359	D-loop; other site
349124007360	H-loop/switch region; other site
349124007361	malate synthase G; Provisional; Region: PRK02999
349124007362	active site
349124007363	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
349124007364	MgtE intracellular N domain; Region: MgtE_N; pfam03448
349124007365	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
349124007366	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
349124007367	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
349124007368	dimer interface [polypeptide binding]; other site
349124007369	active site
349124007370	citrylCoA binding site [chemical binding]; other site
349124007371	NADH binding [chemical binding]; other site
349124007372	cationic pore residues; other site
349124007373	oxalacetate/citrate binding site [chemical binding]; other site
349124007374	coenzyme A binding site [chemical binding]; other site
349124007375	catalytic triad [active]
349124007376	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
349124007377	Transglycosylase; Region: Transgly; pfam00912
349124007378	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
349124007379	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
349124007380	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349124007381	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
349124007382	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349124007383	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
349124007384	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
349124007385	Zn2+ binding site [ion binding]; other site
349124007386	Mg2+ binding site [ion binding]; other site
349124007387	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
349124007388	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
349124007389	active site
349124007390	dimer interface [polypeptide binding]; other site
349124007391	metal binding site [ion binding]; metal-binding site
349124007392	shikimate kinase; Reviewed; Region: aroK; PRK00131
349124007393	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
349124007394	ADP binding site [chemical binding]; other site
349124007395	magnesium binding site [ion binding]; other site
349124007396	putative shikimate binding site; other site
349124007397	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
349124007398	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
349124007399	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
349124007400	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
349124007401	putative active site [active]
349124007402	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
349124007403	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
349124007404	substrate binding site [chemical binding]; other site
349124007405	ATP binding site [chemical binding]; other site
349124007406	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
349124007407	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
349124007408	active site
349124007409	nucleotide binding site [chemical binding]; other site
349124007410	HIGH motif; other site
349124007411	KMSKS motif; other site
349124007412	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
349124007413	Zinc-finger domain; Region: zf-CHCC; cl01821
349124007414	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
349124007415	transcriptional activator RfaH; Region: RfaH; TIGR01955
349124007416	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
349124007417	heterodimer interface [polypeptide binding]; other site
349124007418	homodimer interface [polypeptide binding]; other site
349124007419	Uncharacterized conserved protein [Function unknown]; Region: COG1434
349124007420	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
349124007421	putative active site [active]
349124007422	primosome assembly protein PriA; Validated; Region: PRK05580
349124007423	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
349124007424	ATP binding site [chemical binding]; other site
349124007425	putative Mg++ binding site [ion binding]; other site
349124007426	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
349124007427	helicase superfamily c-terminal domain; Region: HELICc; smart00490
349124007428	nucleotide binding region [chemical binding]; other site
349124007429	ATP-binding site [chemical binding]; other site
349124007430	DNA-J related protein; Region: DNAJ_related; pfam12339
349124007431	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
349124007432	HSP70 interaction site [polypeptide binding]; other site
349124007433	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
349124007434	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
349124007435	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
349124007436	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
349124007437	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
349124007438	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
349124007439	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
349124007440	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
349124007441	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
349124007442	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
349124007443	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
349124007444	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
349124007445	ligand binding site [chemical binding]; other site
349124007446	homodimer interface [polypeptide binding]; other site
349124007447	NAD(P) binding site [chemical binding]; other site
349124007448	trimer interface B [polypeptide binding]; other site
349124007449	trimer interface A [polypeptide binding]; other site
349124007450	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
349124007451	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
349124007452	active site
349124007453	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
349124007454	DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625
349124007455	putative ligand binding site [chemical binding]; other site
349124007456	Fructosamine kinase; Region: Fructosamin_kin; pfam03881
349124007457	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
349124007458	active site lid residues [active]
349124007459	substrate binding pocket [chemical binding]; other site
349124007460	catalytic residues [active]
349124007461	substrate-Mg2+ binding site; other site
349124007462	aspartate-rich region 1; other site
349124007463	aspartate-rich region 2; other site
349124007464	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
349124007465	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
349124007466	catalytic loop [active]
349124007467	iron binding site [ion binding]; other site
349124007468	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
349124007469	FAD binding pocket [chemical binding]; other site
349124007470	FAD binding motif [chemical binding]; other site
349124007471	phosphate binding motif [ion binding]; other site
349124007472	beta-alpha-beta structure motif; other site
349124007473	NAD binding pocket [chemical binding]; other site
349124007474	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
349124007475	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
349124007476	putative catalytic site [active]
349124007477	putative phosphate binding site [ion binding]; other site
349124007478	active site
349124007479	metal binding site A [ion binding]; metal-binding site
349124007480	DNA binding site [nucleotide binding]
349124007481	putative AP binding site [nucleotide binding]; other site
349124007482	putative metal binding site B [ion binding]; other site
349124007483	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
349124007484	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
349124007485	active site
349124007486	catalytic tetrad [active]
349124007487	Ion channel; Region: Ion_trans_2; pfam07885
349124007488	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
349124007489	TrkA-N domain; Region: TrkA_N; pfam02254
349124007490	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
349124007491	TrkA-N domain; Region: TrkA_N; pfam02254
349124007492	muropeptide transporter; Reviewed; Region: ampG; PRK11902
349124007493	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349124007494	putative substrate translocation pore; other site
349124007495	thioredoxin reductase; Provisional; Region: PRK10262
349124007496	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349124007497	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349124007498	isocitrate dehydrogenase; Validated; Region: PRK07362
349124007499	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
349124007500	FOG: CBS domain [General function prediction only]; Region: COG0517
349124007501	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
349124007502	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
349124007503	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
349124007504	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
349124007505	active site
349124007506	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
349124007507	HlyD family secretion protein; Region: HlyD_3; pfam13437
349124007508	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
349124007509	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
349124007510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
349124007511	putative substrate translocation pore; other site
349124007512	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
349124007513	feedback inhibition sensing region; other site
349124007514	homohexameric interface [polypeptide binding]; other site
349124007515	nucleotide binding site [chemical binding]; other site
349124007516	N-acetyl-L-glutamate binding site [chemical binding]; other site
349124007517	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
349124007518	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
349124007519	active site
349124007520	substrate binding site [chemical binding]; other site
349124007521	metal binding site [ion binding]; metal-binding site
349124007522	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
349124007523	trimer interface [polypeptide binding]; other site
349124007524	active site
349124007525	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
349124007526	Flavoprotein; Region: Flavoprotein; pfam02441
349124007527	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
349124007528	hypothetical protein; Reviewed; Region: PRK00024
349124007529	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
349124007530	MPN+ (JAMM) motif; other site
349124007531	Zinc-binding site [ion binding]; other site
349124007532	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
349124007533	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
349124007534	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
349124007535	DNA binding residues [nucleotide binding]
349124007536	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
349124007537	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
349124007538	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
349124007539	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124007540	Walker A/P-loop; other site
349124007541	ATP binding site [chemical binding]; other site
349124007542	Q-loop/lid; other site
349124007543	ABC transporter signature motif; other site
349124007544	Walker B; other site
349124007545	D-loop; other site
349124007546	H-loop/switch region; other site
349124007547	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
349124007548	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
349124007549	P loop; other site
349124007550	GTP binding site [chemical binding]; other site
349124007551	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
349124007552	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
349124007553	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
349124007554	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
349124007555	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
349124007556	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
349124007557	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
349124007558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124007559	S-adenosylmethionine binding site [chemical binding]; other site
349124007560	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
349124007561	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
349124007562	active site
349124007563	(T/H)XGH motif; other site
349124007564	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
349124007565	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
349124007566	DNA binding site [nucleotide binding]
349124007567	catalytic residue [active]
349124007568	H2TH interface [polypeptide binding]; other site
349124007569	putative catalytic residues [active]
349124007570	turnover-facilitating residue; other site
349124007571	intercalation triad [nucleotide binding]; other site
349124007572	8OG recognition residue [nucleotide binding]; other site
349124007573	putative reading head residues; other site
349124007574	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
349124007575	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
349124007576	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
349124007577	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
349124007578	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
349124007579	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
349124007580	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
349124007581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124007582	S-adenosylmethionine binding site [chemical binding]; other site
349124007583	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
349124007584	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
349124007585	putative acyl-acceptor binding pocket; other site
349124007586	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
349124007587	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
349124007588	6-phosphofructokinase; Provisional; Region: PRK14072
349124007589	allosteric effector site; other site
349124007590	dimerization interface [polypeptide binding]; other site
349124007591	active site
349124007592	ADP/pyrophosphate binding site [chemical binding]; other site
349124007593	fructose-1,6-bisphosphate binding site; other site
349124007594	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
349124007595	AMP binding site [chemical binding]; other site
349124007596	metal binding site [ion binding]; metal-binding site
349124007597	active site
349124007598	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
349124007599	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
349124007600	NusB family; Region: NusB; pfam01029
349124007601	putative RNA binding site [nucleotide binding]; other site
349124007602	16S rRNA methyltransferase B; Provisional; Region: PRK10901
349124007603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124007604	S-adenosylmethionine binding site [chemical binding]; other site
349124007605	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
349124007606	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
349124007607	putative active site [active]
349124007608	substrate binding site [chemical binding]; other site
349124007609	putative cosubstrate binding site; other site
349124007610	catalytic site [active]
349124007611	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
349124007612	substrate binding site [chemical binding]; other site
349124007613	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
349124007614	active site
349124007615	catalytic residues [active]
349124007616	metal binding site [ion binding]; metal-binding site
349124007617	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
349124007618	DNA protecting protein DprA; Region: dprA; TIGR00732
349124007619	Protein of unknown function (DUF494); Region: DUF494; pfam04361
349124007620	DNA topoisomerase I; Provisional; Region: PRK08780
349124007621	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
349124007622	active site
349124007623	interdomain interaction site; other site
349124007624	putative metal-binding site [ion binding]; other site
349124007625	nucleotide binding site [chemical binding]; other site
349124007626	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
349124007627	domain I; other site
349124007628	phosphate binding site [ion binding]; other site
349124007629	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
349124007630	domain II; other site
349124007631	domain III; other site
349124007632	nucleotide binding site [chemical binding]; other site
349124007633	DNA binding groove [nucleotide binding]
349124007634	catalytic site [active]
349124007635	domain IV; other site
349124007636	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
349124007637	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
349124007638	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
349124007639	UGMP family protein; Validated; Region: PRK09604
349124007640	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
349124007641	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
349124007642	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
349124007643	Uncharacterized conserved protein [Function unknown]; Region: COG1565
349124007644	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
349124007645	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
349124007646	active site
349124007647	NTP binding site [chemical binding]; other site
349124007648	metal binding triad [ion binding]; metal-binding site
349124007649	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
349124007650	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
349124007651	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
349124007652	putative NAD(P) binding site [chemical binding]; other site
349124007653	active site
349124007654	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
349124007655	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
349124007656	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349124007657	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
349124007658	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
349124007659	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
349124007660	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349124007661	carboxyltransferase (CT) interaction site; other site
349124007662	biotinylation site [posttranslational modification]; other site
349124007663	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
349124007664	Dehydroquinase class II; Region: DHquinase_II; pfam01220
349124007665	active site
349124007666	trimer interface [polypeptide binding]; other site
349124007667	dimer interface [polypeptide binding]; other site
349124007668	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
349124007669	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
349124007670	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
349124007671	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
349124007672	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
349124007673	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
349124007674	oligomerisation interface [polypeptide binding]; other site
349124007675	mobile loop; other site
349124007676	roof hairpin; other site
349124007677	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
349124007678	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
349124007679	ring oligomerisation interface [polypeptide binding]; other site
349124007680	ATP/Mg binding site [chemical binding]; other site
349124007681	stacking interactions; other site
349124007682	hinge regions; other site
349124007683	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
349124007684	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
349124007685	putative acyl-acceptor binding pocket; other site
349124007686	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
349124007687	catalytic center binding site [active]
349124007688	ATP binding site [chemical binding]; other site
349124007689	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
349124007690	homooctamer interface [polypeptide binding]; other site
349124007691	active site
349124007692	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
349124007693	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
349124007694	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349124007695	active site
349124007696	ATP binding site [chemical binding]; other site
349124007697	substrate binding site [chemical binding]; other site
349124007698	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
349124007699	substrate binding site [chemical binding]; other site
349124007700	activation loop (A-loop); other site
349124007701	activation loop (A-loop); other site
349124007702	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
349124007703	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349124007704	metal binding triad; other site
349124007705	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
349124007706	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
349124007707	metal binding triad; other site
349124007708	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
349124007709	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
349124007710	homodimer interface [polypeptide binding]; other site
349124007711	substrate-cofactor binding pocket; other site
349124007712	catalytic residue [active]
349124007713	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
349124007714	ligand-binding site [chemical binding]; other site
349124007715	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
349124007716	transmembrane helices; other site
349124007717	TrkA-C domain; Region: TrkA_C; pfam02080
349124007718	TrkA-C domain; Region: TrkA_C; pfam02080
349124007719	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
349124007720	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
349124007721	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
349124007722	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
349124007723	Active Sites [active]
349124007724	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
349124007725	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
349124007726	CysD dimerization site [polypeptide binding]; other site
349124007727	G1 box; other site
349124007728	putative GEF interaction site [polypeptide binding]; other site
349124007729	GTP/Mg2+ binding site [chemical binding]; other site
349124007730	Switch I region; other site
349124007731	G2 box; other site
349124007732	G3 box; other site
349124007733	Switch II region; other site
349124007734	G4 box; other site
349124007735	G5 box; other site
349124007736	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
349124007737	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
349124007738	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
349124007739	ligand-binding site [chemical binding]; other site
349124007740	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
349124007741	hypothetical protein; Reviewed; Region: PRK09588
349124007742	ykkC-yxkD element as predicted by Rfam (RF00442), score 70.53
349124007743	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
349124007744	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
349124007745	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
349124007746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
349124007747	dimer interface [polypeptide binding]; other site
349124007748	conserved gate region; other site
349124007749	putative PBP binding loops; other site
349124007750	ABC-ATPase subunit interface; other site
349124007751	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
349124007752	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
349124007753	Walker A/P-loop; other site
349124007754	ATP binding site [chemical binding]; other site
349124007755	Q-loop/lid; other site
349124007756	ABC transporter signature motif; other site
349124007757	Walker B; other site
349124007758	D-loop; other site
349124007759	H-loop/switch region; other site
349124007760	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
349124007761	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
349124007762	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
349124007763	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
349124007764	urea carboxylase; Region: urea_carbox; TIGR02712
349124007765	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
349124007766	ATP-grasp domain; Region: ATP-grasp_4; cl17255
349124007767	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
349124007768	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
349124007769	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
349124007770	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
349124007771	carboxyltransferase (CT) interaction site; other site
349124007772	biotinylation site [posttranslational modification]; other site
349124007773	allophanate hydrolase; Provisional; Region: PRK08186
349124007774	Amidase; Region: Amidase; cl11426
349124007775	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
349124007776	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
349124007777	BCCT family transporter; Region: BCCT; pfam02028
349124007778	Chain length determinant protein; Region: Wzz; cl15801
349124007779	PrcB C-terminal; Region: PrcB_C; pfam14343
349124007780	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
349124007781	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
349124007782	catalytic triad [active]
349124007783	putative active site [active]
349124007784	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
349124007785	Interdomain contacts; other site
349124007786	Cytokine receptor motif; other site
349124007787	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166
349124007788	type II secretion system protein D; Region: type_II_gspD; TIGR02517
349124007789	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349124007790	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349124007791	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
349124007792	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
349124007793	type II secretion system protein F; Region: GspF; TIGR02120
349124007794	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349124007795	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
349124007796	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
349124007797	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
349124007798	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
349124007799	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
349124007800	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
349124007801	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
349124007802	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
349124007803	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
349124007804	putative type II secretion protein GspC; Provisional; Region: PRK09681
349124007805	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
349124007806	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
349124007807	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
349124007808	type II secretion system protein E; Region: type_II_gspE; TIGR02533
349124007809	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
349124007810	Walker A motif; other site
349124007811	ATP binding site [chemical binding]; other site
349124007812	Walker B motif; other site
349124007813	High potential iron-sulfur protein; Region: HIPIP; pfam01355
349124007814	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
349124007815	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
349124007816	Protein of unknown function (DUF3374); Region: DUF3374; cl11904
349124007817	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
349124007818	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
349124007819	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
349124007820	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
349124007821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
349124007822	active site
349124007823	phosphorylation site [posttranslational modification]
349124007824	intermolecular recognition site; other site
349124007825	dimerization interface [polypeptide binding]; other site
349124007826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
349124007827	Walker A motif; other site
349124007828	ATP binding site [chemical binding]; other site
349124007829	Walker B motif; other site
349124007830	arginine finger; other site
349124007831	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
349124007832	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
349124007833	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
349124007834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
349124007835	ATP binding site [chemical binding]; other site
349124007836	Mg2+ binding site [ion binding]; other site
349124007837	G-X-G motif; other site
349124007838	LabA_like proteins; Region: LabA_like; cd06167
349124007839	putative metal binding site [ion binding]; other site
349124007840	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
349124007841	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
349124007842	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
349124007843	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
349124007844	GspL periplasmic domain; Region: GspL_C; cl14909
349124007845	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
349124007846	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
349124007847	G1 box; other site
349124007848	GTP/Mg2+ binding site [chemical binding]; other site
349124007849	Switch I region; other site
349124007850	G2 box; other site
349124007851	G3 box; other site
349124007852	Switch II region; other site
349124007853	G4 box; other site
349124007854	G5 box; other site
349124007855	Cytochrome c553 [Energy production and conversion]; Region: COG2863
349124007856	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
349124007857	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
349124007858	Cytochrome c; Region: Cytochrom_C; cl11414
349124007859	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
349124007860	putative catalytic site [active]
349124007861	putative metal binding site [ion binding]; other site
349124007862	putative phosphate binding site [ion binding]; other site
349124007863	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
349124007864	Na2 binding site [ion binding]; other site
349124007865	putative substrate binding site 1 [chemical binding]; other site
349124007866	Na binding site 1 [ion binding]; other site
349124007867	putative substrate binding site 2 [chemical binding]; other site
349124007868	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
349124007869	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
349124007870	trimer interface [polypeptide binding]; other site
349124007871	putative metal binding site [ion binding]; other site
349124007872	glutathione reductase; Validated; Region: PRK06116
349124007873	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
349124007874	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
349124007875	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
349124007876	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
349124007877	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
349124007878	active site
349124007879	Zn binding site [ion binding]; other site
349124007880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124007881	S-adenosylmethionine binding site [chemical binding]; other site
349124007882	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
349124007883	ThiS interaction site; other site
349124007884	putative active site [active]
349124007885	tetramer interface [polypeptide binding]; other site
349124007886	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
349124007887	thiS-thiF/thiG interaction site; other site
349124007888	Transcriptional regulator; Region: Rrf2; cl17282
349124007889	Rrf2 family protein; Region: rrf2_super; TIGR00738
349124007890	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
349124007891	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
349124007892	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
349124007893	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
349124007894	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
349124007895	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
349124007896	Membrane fusogenic activity; Region: BMFP; pfam04380
349124007897	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
349124007898	Nitrogen regulatory protein P-II; Region: P-II; smart00938
349124007899	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
349124007900	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
349124007901	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
349124007902	Walker A/P-loop; other site
349124007903	ATP binding site [chemical binding]; other site
349124007904	Q-loop/lid; other site
349124007905	ABC transporter signature motif; other site
349124007906	Walker B; other site
349124007907	D-loop; other site
349124007908	H-loop/switch region; other site
349124007909	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
349124007910	spermidine synthase; Provisional; Region: PRK00811
349124007911	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
349124007912	S-adenosylmethionine binding site [chemical binding]; other site
349124007913	arginine decarboxylase; Provisional; Region: PRK05354
349124007914	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
349124007915	dimer interface [polypeptide binding]; other site
349124007916	active site
349124007917	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
349124007918	catalytic residues [active]
349124007919	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
349124007920	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
349124007921	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
349124007922	Sporulation related domain; Region: SPOR; pfam05036
349124007923	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
349124007924	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
349124007925	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
349124007926	active site
349124007927	HIGH motif; other site
349124007928	nucleotide binding site [chemical binding]; other site
349124007929	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
349124007930	KMSK motif region; other site
349124007931	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
349124007932	tRNA binding surface [nucleotide binding]; other site
349124007933	anticodon binding site; other site
349124007934	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
349124007935	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
349124007936	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
349124007937	Walker A/P-loop; other site
349124007938	ATP binding site [chemical binding]; other site
349124007939	Q-loop/lid; other site
349124007940	ABC transporter signature motif; other site
349124007941	Walker B; other site
349124007942	D-loop; other site
349124007943	H-loop/switch region; other site
349124007944	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
349124007945	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
349124007946	Walker A/P-loop; other site
349124007947	ATP binding site [chemical binding]; other site
349124007948	Q-loop/lid; other site
349124007949	ABC transporter signature motif; other site
349124007950	Walker B; other site
349124007951	D-loop; other site
349124007952	H-loop/switch region; other site
349124007953	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
349124007954	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
349124007955	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
349124007956	DNA polymerase I; Provisional; Region: PRK05755
349124007957	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
349124007958	active site
349124007959	metal binding site 1 [ion binding]; metal-binding site
349124007960	putative 5' ssDNA interaction site; other site
349124007961	metal binding site 3; metal-binding site
349124007962	metal binding site 2 [ion binding]; metal-binding site
349124007963	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
349124007964	putative DNA binding site [nucleotide binding]; other site
349124007965	putative metal binding site [ion binding]; other site
349124007966	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
349124007967	active site
349124007968	catalytic site [active]
349124007969	substrate binding site [chemical binding]; other site
349124007970	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
349124007971	active site
349124007972	DNA binding site [nucleotide binding]
349124007973	catalytic site [active]
349124007974	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
349124007975	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
349124007976	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
349124007977	Part of AAA domain; Region: AAA_19; pfam13245
349124007978	Family description; Region: UvrD_C_2; pfam13538
349124007979	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
349124007980	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
349124007981	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
349124007982	dimerization interface [polypeptide binding]; other site
349124007983	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
349124007984	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
349124007985	glutaminase active site [active]
349124007986	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
349124007987	dimer interface [polypeptide binding]; other site
349124007988	active site
349124007989	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
349124007990	dimer interface [polypeptide binding]; other site
349124007991	active site
349124007992	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124007993	Ligand Binding Site [chemical binding]; other site
349124007994	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
349124007995	Ligand Binding Site [chemical binding]; other site
349124007996	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
349124007997	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
349124007998	Substrate binding site; other site
349124007999	Mg++ binding site; other site
349124008000	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
349124008001	active site
349124008002	substrate binding site [chemical binding]; other site
349124008003	CoA binding site [chemical binding]; other site
349124008004	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
349124008005	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
349124008006	gamma subunit interface [polypeptide binding]; other site
349124008007	epsilon subunit interface [polypeptide binding]; other site
349124008008	LBP interface [polypeptide binding]; other site
349124008009	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
349124008010	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349124008011	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
349124008012	alpha subunit interaction interface [polypeptide binding]; other site
349124008013	Walker A motif; other site
349124008014	ATP binding site [chemical binding]; other site
349124008015	Walker B motif; other site
349124008016	inhibitor binding site; inhibition site
349124008017	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
349124008018	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
349124008019	core domain interface [polypeptide binding]; other site
349124008020	delta subunit interface [polypeptide binding]; other site
349124008021	epsilon subunit interface [polypeptide binding]; other site
349124008022	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
349124008023	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
349124008024	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
349124008025	beta subunit interaction interface [polypeptide binding]; other site
349124008026	Walker A motif; other site
349124008027	ATP binding site [chemical binding]; other site
349124008028	Walker B motif; other site
349124008029	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
349124008030	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
349124008031	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
349124008032	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
349124008033	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
349124008034	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
349124008035	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
349124008036	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
349124008037	ATP synthase I chain; Region: ATP_synt_I; cl09170
349124008038	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
349124008039	ParB-like nuclease domain; Region: ParBc; pfam02195
349124008040	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
349124008041	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349124008042	P-loop; other site
349124008043	Magnesium ion binding site [ion binding]; other site
349124008044	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
349124008045	Magnesium ion binding site [ion binding]; other site